clonidine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
alpha-2 adrenoreceptor agonists 704 4205-90-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clonidine
  • clonidine hydrochloride
  • clonidine HCl
An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
  • Molecular weight: 230.09
  • Formula: C9H9Cl2N3
  • CLOGP: 1.73
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 36.42
  • ALOGS: -2.68
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.45 mg O
0.45 mg P
0.10 mg O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.17 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Hosey CM, Chan R, Benet LZ
EoM (Fraction excreted unchanged in urine) 62 % Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 95 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.56 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.60 hours Lombardo F, Berellini G, Obach RS
S (Water solubility) 50 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Sept. 3, 1974 FDA BOEHRINGER INGELHEIM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Temperature regulation disorder 399.07 9.97 171 65427 5961 63417463
Completed suicide 328.90 9.97 561 65037 145112 63278312
Food allergy 301.13 9.97 172 65426 11229 63412195
Coeliac disease 280.13 9.97 171 65427 12626 63410798
Immunodeficiency 211.41 9.97 172 65426 20082 63403342
Bradycardia 193.46 9.97 303 65295 72924 63350500
Bursitis 186.00 9.97 210 65388 36831 63386593
Hypertension 183.19 9.97 669 64929 278634 63144790
Hyperhidrosis 180.02 9.97 365 65233 107471 63315953
Hypertensive crisis 164.16 9.97 132 65466 15154 63408270
Cardiac failure congestive 161.61 9.97 319 65279 92114 63331310
Drug withdrawal syndrome 155.34 9.97 165 65433 27029 63396395
Pemphigus 150.64 9.97 10 65588 183716 63239708
Rash erythematous 142.76 9.97 197 65401 42313 63381111
Overdose 138.61 9.97 342 65256 114736 63308688
Mental status changes 135.22 9.97 185 65413 39414 63384010
Synovitis 135.05 9.97 17 65581 186901 63236523
Hand deformity 132.74 9.97 8 65590 159449 63263975
Fluid retention 132.01 9.97 228 65370 59458 63363966
Glossodynia 125.11 9.97 18 65580 178858 63244566
Systemic lupus erythematosus 119.27 9.97 34 65564 208884 63214540
Arthropathy 112.34 9.97 51 65547 234741 63188683
Blood pressure inadequately controlled 107.60 9.97 66 65532 4912 63418512
Application site rash 103.77 9.97 51 65547 2447 63420977
Blood pressure increased 103.35 9.97 385 65213 161677 63261747
Pericarditis 99.97 9.97 10 65588 131569 63291855
Body tinea 98.26 9.97 45 65553 1840 63421584
Application site pruritus 96.94 9.97 57 65541 3927 63419497
Anti-cyclic citrullinated peptide antibody positive 96.19 9.97 6 65592 116206 63307218
Upper respiratory tract infection 93.68 9.97 239 65359 81808 63341616
Hypotension 89.75 9.97 534 65064 272070 63151354
Maternal exposure during pregnancy 89.00 9.97 59 65539 220003 63203421
Neovascularisation 88.15 9.97 36 65562 1109 63422315
Nephrogenic systemic fibrosis 87.40 9.97 56 65542 4500 63418924
Product adhesion issue 83.16 9.97 55 65543 4664 63418760
Alopecia 82.22 9.97 139 65459 337397 63086027
Sinus bradycardia 80.81 9.97 87 65511 14464 63408960
Inhibitory drug interaction 80.67 9.97 45 65553 2804 63420620
Wound 80.37 9.97 34 65564 163229 63260195
Cerebrovascular accident 80.32 9.97 270 65328 107754 63315670
Joint swelling 78.83 9.97 136 65462 327530 63095894
Poisoning 78.00 9.97 83 65515 13617 63409807
Paradoxical drug reaction 74.65 9.97 49 65549 4103 63419321
Hypertensive encephalopathy 73.90 9.97 27 65571 611 63422813
Application site erythema 72.50 9.97 51 65547 4784 63418640
Constipation 72.30 9.97 438 65160 224505 63198919
Infection susceptibility increased 71.84 9.97 45 65553 3476 63419948
Withdrawal syndrome 69.12 9.97 94 65504 19903 63403521
Drug intolerance 68.99 9.97 134 65464 308527 63114897
Therapeutic product effect decreased 67.63 9.97 60 65538 193127 63230297
Somnolence 63.27 9.97 357 65241 178328 63245096
Withdrawal hypertension 63.24 9.97 17 65581 131 63423293
Discomfort 62.26 9.97 49 65549 167325 63256099
Accidental exposure to product by child 60.68 9.97 28 65570 1165 63422259
Application site irritation 58.91 9.97 31 65567 1719 63421705
Duodenal ulcer perforation 58.17 9.97 10 65588 87199 63336225
Rheumatoid factor positive 57.82 9.97 9 65589 84397 63339027
Swelling 56.91 9.97 125 65473 275253 63148171
Glucose tolerance impaired 56.60 9.97 50 65548 6527 63416897
Toxicity to various agents 55.50 9.97 441 65157 246809 63176615
Folliculitis 54.31 9.97 5 65593 70312 63353112
Abdominal discomfort 53.75 9.97 162 65436 320723 63102701
Muscle injury 52.24 9.97 4 65594 65341 63358083
Sedation 50.59 9.97 119 65479 38690 63384734
Myocardial infarction 50.58 9.97 221 65377 99672 63323752
Rash 50.43 9.97 356 65242 560515 62862909
Arthralgia 49.58 9.97 365 65233 569345 62854079
Acute motor-sensory axonal neuropathy 48 9.97 16 65582 273 63423151
Lower respiratory tract infection 47.62 9.97 40 65558 132267 63291157
Asthma 46.54 9.97 257 65341 127304 63296120
Chronic kidney disease 46.45 9.97 127 65471 45271 63378153
Neutropenia 46.41 9.97 68 65530 174937 63248487
Product tampering 45.87 9.97 17 65581 401 63423023
Unresponsive to stimuli 45.51 9.97 105 65493 33711 63389713
Malignant catatonia 45.23 9.97 14 65584 186 63423238
Infusion related reaction 44.74 9.97 119 65479 245402 63178022
Impaired healing 43.47 9.97 26 65572 102516 63320908
Hypertensive emergency 43.37 9.97 26 65572 1856 63421568
Cardiac arrest 43.29 9.97 200 65398 92345 63331079
Intestinal angioedema 41.73 9.97 18 65580 637 63422787
Adulterated product 41.72 9.97 14 65584 244 63423180
Irritable bowel syndrome 40.80 9.97 17 65581 82395 63341029
Malignant hypertension 39.45 9.97 21 65577 1192 63422232
Impaired quality of life 39.12 9.97 59 65539 13724 63409700
Poor quality sleep 38.73 9.97 72 65526 19863 63403561
Nasopharyngitis 38.62 9.97 134 65464 254123 63169301
Hyperlipidaemia 38.41 9.97 71 65527 19500 63403924
Infection 38.12 9.97 116 65482 229057 63194367
Peritonitis bacterial 37.87 9.97 35 65563 4844 63418580
Gastrointestinal disorder 37.81 9.97 48 65550 131191 63292233
Suspected suicide 37.75 9.97 40 65558 6528 63416896
Anti-neutrophil cytoplasmic antibody positive vasculitis 37.59 9.97 28 65570 2871 63420553
Nodal rhythm 37.39 9.97 23 65575 1720 63421704
Skin induration 37.10 9.97 29 65569 3194 63420230
Sleep disorder due to general medical condition, insomnia type 37.08 9.97 5 65593 52212 63371212
Claustrophobia 37.04 9.97 19 65579 999 63422425
Hypothermia 36.94 9.97 57 65541 13524 63409900
Product substitution issue 36.51 9.97 62 65536 15934 63407490
Acute myocardial infarction 36.04 9.97 93 65505 32031 63391393
Left ventricular hypertrophy 35.32 9.97 35 65563 5280 63418144
Respiratory arrest 35.08 9.97 93 65505 32552 63390872
Helicobacter infection 34.69 9.97 27 65571 92758 63330666
Malignant neoplasm progression 34.56 9.97 21 65577 82100 63341324
Febrile neutropenia 34.46 9.97 43 65555 118406 63305018
Back pain 34.14 9.97 420 65178 263725 63159699
Purpura 34.13 9.97 50 65548 11335 63412089
Sinusitis 33.38 9.97 121 65477 226532 63196892
Pulse abnormal 33.29 9.97 24 65574 2340 63421084
Miosis 32.40 9.97 39 65559 7314 63416110
Cardio-respiratory arrest 32.15 9.97 135 65463 59824 63363600
Blister 31.97 9.97 53 65545 129761 63293663
Anuria 31.82 9.97 51 65547 12500 63410924
Coronary artery disease 31.56 9.97 89 65509 32288 63391136
Intentional product misuse 31.00 9.97 135 65463 60782 63362642
Skin hypertrophy 29.62 9.97 26 65572 3365 63420059
Medical device site pain 29.45 9.97 10 65588 181 63423243
Psoriatic arthropathy 29.02 9.97 31 65567 91489 63331935
Contraindicated product administered 28.97 9.97 121 65477 217527 63205897
Respiratory moniliasis 28.90 9.97 10 65588 192 63423232
Skin disorder 28.66 9.97 81 65517 29426 63393998
Lethargy 28.41 9.97 124 65474 55883 63367541
Extrapyramidal disorder 28.38 9.97 50 65548 13234 63410190
Anaesthesia 27.87 9.97 12 65586 423 63423001
Condition aggravated 27.60 9.97 274 65324 401943 63021481
Musculoskeletal stiffness 27.55 9.97 98 65500 184520 63238904
Basal ganglion degeneration 27.53 9.97 12 65586 436 63422988
Bone density decreased 27.42 9.97 52 65546 14560 63408864
Interstitial lung disease 27.23 9.97 15 65583 61893 63361531
Agitation 27.10 9.97 128 65470 59629 63363795
Tissue infiltration 26.60 9.97 13 65585 616 63422808
Erythema 26.51 9.97 288 65310 175463 63247961
Abortion spontaneous 26.32 9.97 8 65590 47187 63376237
Implant site extravasation 26.29 9.97 12 65586 487 63422937
Epilepsy with myoclonic-atonic seizures 25.93 9.97 8 65590 105 63423319
Primary hyperaldosteronism 25.81 9.97 7 65591 56 63423368
Urinary incontinence 25.54 9.97 82 65516 31932 63391492
Blood aldosterone increased 25.04 9.97 9 65589 194 63423230
Accidental overdose 24.63 9.97 66 65532 23243 63400181
Rheumatic fever 24.60 9.97 7 65591 43104 63380320
Drug dependence 23.57 9.97 67 65531 24416 63399008
Encephalomalacia 23.31 9.97 11 65587 482 63422942
Retrograde amnesia 23.16 9.97 11 65587 489 63422935
Sympathomimetic effect 22.90 9.97 7 65591 89 63423335
Drug ineffective for unapproved indication 22.57 9.97 82 65516 33981 63389443
Prescribed overdose 22.45 9.97 82 65516 34071 63389353
Respiratory depression 22.34 9.97 46 65552 13669 63409755
Medication error 22.27 9.97 110 65488 52174 63371250
Drug ineffective 22.12 9.97 870 64728 1043895 62379529
Renin decreased 21.77 9.97 7 65591 106 63423318
Leukopenia 21.50 9.97 29 65569 77261 63346163
Diarrhoea 20.98 9.97 571 65027 714795 62708629
Apnoea 20.89 9.97 33 65565 7989 63415435
Norepinephrine increased 20.67 9.97 6 65592 63 63423361
Depressed level of consciousness 20.61 9.97 122 65476 61956 63361468
Somatic symptom disorder 20.49 9.97 19 65579 2641 63420783
Swollen joint count increased 20.30 9.97 6 65592 36048 63387376
Loss of personal independence in daily activities 20.19 9.97 44 65554 97246 63326178
Application site papules 19.94 9.97 6 65592 72 63423352
Application site pain 19.78 9.97 23 65575 4159 63419265
Pulse absent 19.70 9.97 26 65572 5348 63418076
Ill-defined disorder 19.55 9.97 34 65564 81721 63341703
Medical device site discharge 19.54 9.97 5 65593 31 63423393
C-reactive protein increased 19.52 9.97 43 65555 94664 63328760
Injection site erythema 19.52 9.97 35 65563 83139 63340285
Osteonecrosis of jaw 19.50 9.97 6 65592 35117 63388307
White blood cell count decreased 19.34 9.97 76 65522 139028 63284396
Atrioventricular block second degree 19.31 9.97 22 65576 3892 63419532
Coma scale abnormal 18.99 9.97 25 65573 5128 63418296
Impaired work ability 18.99 9.97 50 65548 17425 63405999
Hypoventilation 18.99 9.97 24 65574 4730 63418694
Myocardial ischaemia 18.49 9.97 41 65557 12818 63410606
Gastrointestinal tract mucosal pigmentation 18.40 9.97 10 65588 592 63422832
Arthritis 18.32 9.97 60 65538 115861 63307563
Implant site infection 18.31 9.97 12 65586 1002 63422422
Renal failure 18.29 9.97 194 65404 117458 63305966
Dialysis 18.21 9.97 36 65562 10391 63413033
Uterine enlargement 18.14 9.97 13 65585 1255 63422169
Anhedonia 18.10 9.97 37 65561 10937 63412487
Foetal death 18.09 9.97 37 65561 10943 63412481
Pulmonary renal syndrome 18.06 9.97 9 65589 445 63422979
Application site discolouration 18.04 9.97 11 65587 810 63422614
Neutrophil count decreased 18.00 9.97 19 65579 56387 63367037
Page kidney 17.97 9.97 4 65594 12 63423412
Pyrexia 17.81 9.97 361 65237 470117 62953307
Disease progression 17.75 9.97 66 65532 122692 63300732
Hip arthroplasty 17.63 9.97 14 65584 47632 63375792
Pernicious anaemia 17.34 9.97 10 65588 664 63422760
Peripheral swelling 17.05 9.97 184 65414 265758 63157666
Blood pressure abnormal 17.04 9.97 44 65554 15154 63408270
Vascular stenosis 16.92 9.97 8 65590 352 63423072
Hypertrichosis 16.90 9.97 12 65586 1142 63422282
Gamma-glutamyltransferase increased 16.87 9.97 7 65591 34024 63389400
Inguinal hernia 16.76 9.97 15 65583 1992 63421432
Seizure 16.72 9.97 210 65388 132424 63291000
Klebsiella infection 16.71 9.97 31 65567 8535 63414889
Application site vesicles 16.71 9.97 13 65585 1422 63422002
Human herpesvirus 6 infection reactivation 16.63 9.97 8 65590 366 63423058
Loss of consciousness 16.63 9.97 191 65407 117930 63305494
Cerebral ischaemia 16.59 9.97 27 65571 6701 63416723
Knee arthroplasty 16.48 9.97 19 65579 54187 63369237
Focal segmental glomerulosclerosis 16.45 9.97 13 65585 1455 63421969
Hyperreflexia 16.27 9.97 25 65573 5909 63417515
Renal transplant failure 16.21 9.97 10 65588 752 63422672
Glomerulonephritis rapidly progressive 16.10 9.97 11 65587 984 63422440
Hyperlactacidaemia 15.76 9.97 17 65581 2832 63420592
Medical device site erythema 15.75 9.97 4 65594 24 63423400
Change in seizure presentation 15.70 9.97 8 65590 415 63423009
Tachyphylaxis 15.69 9.97 7 65591 269 63423155
Brain injury 15.68 9.97 27 65571 7016 63416408
Pulmonary fibrosis 15.63 9.97 11 65587 39798 63383626
Cardiac hypertrophy 15.61 9.97 11 65587 1034 63422390
Neurological symptom 15.35 9.97 24 65574 5759 63417665
Human ehrlichiosis 15.29 9.97 6 65592 166 63423258
Posterior reversible encephalopathy syndrome 15.29 9.97 46 65552 17299 63406125
Intentional product use issue 15.26 9.97 74 65524 127818 63295606
Iliac artery stenosis 15.24 9.97 5 65593 81 63423343
Haematochezia 14.98 9.97 20 65578 53524 63369900
Basal ganglia haemorrhage 14.98 9.97 9 65589 645 63422779
Alanine aminotransferase increased 14.87 9.97 56 65542 103714 63319710
Normochromic normocytic anaemia 14.83 9.97 21 65577 4615 63418809
Device expulsion 14.59 9.97 9 65589 34913 63388511
Off label use 14.56 9.97 560 65038 673902 62749522
Sinus arrhythmia 14.30 9.97 12 65586 1461 63421963
Arteriospasm coronary 14.24 9.97 19 65579 3949 63419475
Therapeutic drug monitoring analysis incorrectly performed 14.22 9.97 7 65591 337 63423087
Rhinorrhoea 14.16 9.97 29 65569 65548 63357876
Liver disorder 14.08 9.97 21 65577 53666 63369758
Mood swings 13.89 9.97 46 65552 18202 63405222
Hyperaesthesia 13.64 9.97 30 65568 9328 63414096
Hepatic function abnormal 13.64 9.97 11 65587 37131 63386293
Feeling abnormal 13.53 9.97 222 65376 148170 63275254
Pain in jaw 13.49 9.97 15 65583 43481 63379943
Aggression 13.45 9.97 54 65544 23444 63399980
Systolic dysfunction 13.45 9.97 12 65586 1587 63421837
Mobility decreased 13.38 9.97 72 65526 121087 63302337
Paranoia 13.29 9.97 34 65564 11645 63411779
Tremor 13.25 9.97 201 65397 132038 63291386
Patent ductus arteriosus 13.23 9.97 19 65579 4231 63419193
Device programming error 13.22 9.97 5 65593 125 63423299
Haemorrhage intracranial 13.19 9.97 37 65561 13382 63410042
Neoplasm progression 13.11 9.97 11 65587 36417 63387007
Psychogenic seizure 12.87 9.97 12 65586 1680 63421744
Emotional distress 12.82 9.97 67 65531 32482 63390942
Intercepted medication error 12.82 9.97 8 65590 614 63422810
End stage renal disease 12.78 9.97 24 65574 6669 63416755
Device infusion issue 12.77 9.97 13 65585 2025 63421399
Skin fibrosis 12.54 9.97 9 65589 871 63422553
Injection site pruritus 12.47 9.97 17 65581 45099 63378325
Hypertensive heart disease 12.47 9.97 14 65584 2438 63420986
Femur fracture 12.30 9.97 15 65583 41741 63381683
Chest pain 12.28 9.97 301 65297 215658 63207766
Product quality issue 12.23 9.97 71 65527 35794 63387630
BRASH syndrome 12.18 9.97 7 65591 462 63422962
Injection site abscess 12.13 9.97 10 65588 1188 63422236
Exposure via ingestion 12.12 9.97 15 65583 2894 63420530
Trichoglossia 12.11 9.97 6 65592 293 63423131
Drug abuser 12.06 9.97 15 65583 2908 63420516
Fibrosis 11.97 9.97 18 65580 4174 63419250
Colitis ulcerative 11.95 9.97 6 65592 26085 63397339
Left atrial dilatation 11.90 9.97 12 65586 1849 63421575
Akathisia 11.87 9.97 28 65570 9118 63414306
Kidney fibrosis 11.79 9.97 12 65586 1869 63421555
Hypernatraemia 11.79 9.97 25 65573 7584 63415840
Anion gap increased 11.78 9.97 12 65586 1870 63421554
Atrioventricular block 11.70 9.97 25 65573 7622 63415802
Suicidal ideation 11.68 9.97 107 65491 62314 63361110
Acute lung injury 11.67 9.97 11 65587 1560 63421864
Left ventricular failure 11.63 9.97 21 65577 5666 63417758
Hypertensive urgency 11.60 9.97 6 65592 321 63423103
Live birth 11.58 9.97 6 65592 25624 63397800
Implant site haematoma 11.50 9.97 4 65594 78 63423346
Cerebellar atrophy 11.47 9.97 8 65590 740 63422684
Cellulitis 11.30 9.97 132 65466 81826 63341598
Application site haematoma 11.29 9.97 3 65595 22 63423402
Blood glucose increased 11.15 9.97 134 65464 83622 63339802
Headache 11.14 9.97 778 64820 632463 62790961
Melaena 11.14 9.97 9 65589 30356 63393068
Pneumonia respiratory syncytial viral 11.13 9.97 9 65589 1041 63422383
Medical device site swelling 11.06 9.97 3 65595 24 63423400
Factitious disorder 11.05 9.97 4 65594 88 63423336
Daydreaming 11.01 9.97 6 65592 357 63423067
Monoplegia 10.99 9.97 15 65583 3186 63420238
Drug screen positive 10.97 9.97 16 65582 3613 63419811
Drug dependence, antepartum 10.85 9.97 3 65595 26 63423398
Infusion site mass 10.85 9.97 12 65586 2056 63421368
Fanconi syndrome 10.83 9.97 10 65588 1382 63422042
Joint contracture 10.81 9.97 11 65587 1713 63421711
Spinal pain 10.79 9.97 34 65564 13105 63410319
Electrocardiogram abnormal 10.74 9.97 27 65571 9152 63414272
Macular degeneration 10.58 9.97 6 65592 24370 63399054
SJS-TEN overlap 10.56 9.97 6 65592 387 63423037
Joint injury 10.56 9.97 9 65589 29563 63393861
Labile blood pressure 10.47 9.97 11 65587 1778 63421646
Blood potassium increased 10.42 9.97 42 65556 18267 63405157
Glomerulonephritis 10.38 9.97 11 65587 1795 63421629
Alcoholism 10.32 9.97 11 65587 1807 63421617
Implant site hypersensitivity 10.29 9.97 3 65595 32 63423392
Macroangiopathy 10.22 9.97 4 65594 110 63423314
Hypervolaemia 10.18 9.97 57 65541 28356 63395068
Inflammation 10.17 9.97 47 65551 82226 63341198
Pruritus 10.16 9.97 290 65308 361163 63062261
Enterococcal infection 10.15 9.97 24 65574 7824 63415600
Neurological decompensation 10.04 9.97 13 65585 2625 63420799

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 229.73 11.35 418 41605 97750 34817158
Drug withdrawal syndrome 208.00 11.35 180 41843 19654 34895254
Aggression 161.35 11.35 216 41807 38748 34876160
Bradycardia 157.45 11.35 306 41717 75112 34839796
Withdrawal hypertension 129.51 11.35 33 41990 168 34914740
Respiratory depression 124.86 11.35 124 41899 16121 34898787
Drug dependence 98.29 11.35 133 41890 24084 34890824
Hypertensive crisis 88.84 11.35 78 41945 8673 34906235
Hypertension 86.69 11.35 359 41664 136084 34778824
Withdrawal syndrome 81.13 11.35 87 41936 12368 34902540
Victim of child abuse 79.94 11.35 33 41990 894 34914014
Oppositional defiant disorder 77.61 11.35 28 41995 521 34914387
Hypotension 73.73 11.35 487 41536 221162 34693746
Decreased eye contact 72.81 11.35 26 41997 469 34914439
Choreoathetosis 69.11 11.35 31 41992 1033 34913875
Application site rash 68.83 11.35 29 41994 828 34914080
Blood pressure inadequately controlled 67.10 11.35 41 41982 2599 34912309
Obesity 63.66 11.35 78 41945 12800 34902108
Epidural lipomatosis 59.95 11.35 28 41995 1026 34913882
Accidental exposure to product by child 59.46 11.35 31 41992 1445 34913463
Agitation 58.88 11.35 177 41846 57222 34857686
Anxiety 57.97 11.35 255 41768 99173 34815735
Sedation 57.51 11.35 96 41927 20910 34893998
Sinus bradycardia 56.91 11.35 74 41949 12889 34902019
Cardiac failure congestive 55.90 11.35 223 41800 83047 34831861
Product substitution issue 54.58 11.35 64 41959 10031 34904877
Miosis 54.15 11.35 62 41961 9473 34905435
Dystonia 52.50 11.35 65 41958 10780 34904128
Blood prolactin increased 51.68 11.35 30 41993 1730 34913178
Mental status changes 51.54 11.35 130 41893 37953 34876955
Somnolence 51.01 11.35 266 41757 110850 34804058
Blood pressure increased 50.62 11.35 225 41798 87877 34827031
Overweight 49.70 11.35 30 41993 1860 34913048
Crying 49.25 11.35 47 41976 5815 34909093
Trismus 49.15 11.35 33 41990 2462 34912446
Psychomotor hyperactivity 48.73 11.35 59 41964 9563 34905345
Febrile neutropenia 48.31 11.35 56 41967 136793 34778115
Homicidal ideation 46.99 11.35 33 41990 2649 34912259
Bruxism 46.81 11.35 28 41995 1707 34913201
Neuroleptic malignant syndrome 46.50 11.35 80 41943 17854 34897054
Hypertensive emergency 45.24 11.35 23 42000 1017 34913891
Juvenile idiopathic arthritis 44.51 11.35 28 41995 1869 34913039
Product adhesion issue 43.63 11.35 26 41997 1574 34913334
Nephrogenic systemic fibrosis 43.28 11.35 37 41986 3968 34910940
Lethargy 41.40 11.35 126 41897 40996 34873912
Toxic epidermal necrolysis 40.50 11.35 84 41939 21562 34893346
Serotonin syndrome 40.44 11.35 80 41943 19853 34895055
Interstitial lung disease 40.40 11.35 14 42009 65268 34849640
Irritability 39.56 11.35 90 41933 24600 34890308
Pneumonia 39.38 11.35 265 41758 362362 34552546
Toxicity to various agents 39.08 11.35 390 41633 199972 34714936
Suicidal ideation 39.03 11.35 122 41901 40266 34874642
Thrombocytopenia 38.84 11.35 81 41942 156166 34758742
Cerebrovascular accident 38.19 11.35 202 41821 84609 34830299
Cardiac arrest 37.95 11.35 221 41802 95938 34818970
Malignant catatonia 36.48 11.35 13 42010 233 34914675
Product prescribing error 36.10 11.35 83 41940 22844 34892064
Application site pruritus 35.71 11.35 22 42001 1415 34913493
Peritonitis bacterial 35.15 11.35 40 41983 6070 34908838
Catatonia 34.31 11.35 36 41987 4989 34909919
Device failure 34.29 11.35 26 41997 2350 34912558
Respiratory arrest 34.12 11.35 92 41931 27951 34886957
Dyskinesia 34.04 11.35 80 41943 22333 34892575
Emotional distress 33.79 11.35 63 41960 14963 34899945
Aplastic anaemia 32.96 11.35 49 41974 9667 34905241
Neutropenia 32.81 11.35 89 41934 156689 34758219
Malignant neoplasm progression 32.17 11.35 35 41988 88011 34826897
Hepatic function abnormal 32.14 11.35 7 42016 44356 34870552
Sedation complication 31.45 11.35 22 42001 1755 34913153
Tic 30.76 11.35 23 42000 2035 34912873
Suspected suicide 30.62 11.35 33 41990 4715 34910193
Pancytopenia 30.37 11.35 42 41981 95115 34819793
Hypotonia 30.15 11.35 42 41981 7811 34907097
Tardive dyskinesia 30.13 11.35 36 41987 5754 34909154
Pyrexia 30.12 11.35 256 41767 332757 34582151
Child abuse 29.53 11.35 13 42010 414 34914494
Overdose 29.50 11.35 199 41824 90860 34824048
Intestinal pseudo-obstruction 29.36 11.35 21 42002 1735 34913173
Unresponsive to stimuli 29.18 11.35 86 41937 27483 34887425
Accidental overdose 28.55 11.35 70 41953 20070 34894838
Autonomic nervous system imbalance 28.45 11.35 24 41999 2527 34912381
Application site erythema 28.18 11.35 23 42000 2313 34912595
Hyperaesthesia 27.81 11.35 31 41992 4599 34910309
Anal inflammation 27.56 11.35 18 42005 1282 34913626
Application site irritation 26.30 11.35 14 42009 681 34914227
Affect lability 26.25 11.35 27 41996 3656 34911252
Kidney transplant rejection 25.70 11.35 38 41985 7459 34907449
Accelerated hypertension 25.04 11.35 10 42013 248 34914660
Drug ineffective for unapproved indication 24.17 11.35 73 41950 23642 34891266
General physical health deterioration 23.80 11.35 77 41946 128192 34786716
SARS-CoV-2 test negative 23.79 11.35 15 42008 1005 34913903
Inadequate analgesia 23.39 11.35 23 42000 2952 34911956
Natural killer cell count decreased 22.90 11.35 4 42019 0 34914908
Labile hypertension 22.77 11.35 7 42016 77 34914831
Galactorrhoea 22.68 11.35 11 42012 439 34914469
Injury 22.34 11.35 65 41958 20622 34894286
Rheumatoid arthritis 22.31 11.35 9 42014 38229 34876679
Corneal reflex decreased 21.41 11.35 8 42015 165 34914743
Paradoxical drug reaction 21.10 11.35 23 42000 3328 34911580
Insomnia 21.05 11.35 204 41819 103703 34811205
Platelet count decreased 20.75 11.35 74 41949 119643 34795265
Hyperkinesia 20.48 11.35 17 42006 1751 34913157
Product preparation issue 20.41 11.35 10 42013 408 34914500
Stress cardiomyopathy 20.19 11.35 18 42005 2041 34912867
Abnormal behaviour 20.16 11.35 71 41952 24898 34890010
Anger 19.79 11.35 44 41979 11840 34903068
Product administered to patient of inappropriate age 19.71 11.35 22 42001 3269 34911639
Coordination abnormal 19.68 11.35 34 41989 7610 34907298
Drug screen positive 19.67 11.35 24 41999 3919 34910989
Tourette's disorder 19.05 11.35 6 42017 72 34914836
Speech disorder 19.01 11.35 71 41952 25615 34889293
Neutrophil count decreased 19.01 11.35 20 42003 51084 34863824
Poisoning 18.96 11.35 44 41979 12182 34902726
Medical device site pain 18.90 11.35 6 42017 74 34914834
Fibrosis 18.82 11.35 19 42004 2517 34912391
Pain 18.82 11.35 348 41675 204327 34710581
Attention deficit hyperactivity disorder 18.67 11.35 19 42004 2540 34912368
Drug tolerance 18.53 11.35 20 42003 2862 34912046
Axillary pain 18.22 11.35 9 42014 374 34914534
Respiratory rate decreased 18.10 11.35 18 42005 2341 34912567
Disease progression 17.94 11.35 68 41955 108009 34806899
Diarrhoea 17.87 11.35 346 41677 389566 34525342
Prostate cancer 17.79 11.35 13 42010 39636 34875272
Implant site extravasation 17.70 11.35 9 42014 398 34914510
Inflammation 17.61 11.35 6 42017 28289 34886619
Product prescribing issue 17.42 11.35 17 42006 2162 34912746
Anhedonia 17.30 11.35 32 41991 7553 34907355
Infection 17.26 11.35 54 41969 90861 34824047
Mood altered 17.05 11.35 35 41988 8917 34905991
Accidental poisoning 16.90 11.35 11 42012 779 34914129
Loss of consciousness 16.59 11.35 162 41861 82505 34832403
Poor quality sleep 16.58 11.35 33 41990 8223 34906685
Metabolic alkalosis 16.49 11.35 14 42009 1487 34913421
Drug ineffective 16.49 11.35 688 41335 456063 34458845
Oromandibular dystonia 15.94 11.35 9 42014 492 34914416
Brief psychotic disorder with marked stressors 15.87 11.35 7 42016 224 34914684
Product use issue 15.82 11.35 130 41893 63086 34851822
Cytokine release syndrome 15.80 11.35 4 42019 22873 34892035
Reaction to excipient 15.71 11.35 9 42014 506 34914402
Cardio-respiratory arrest 15.67 11.35 117 41906 55156 34859752
Device power source issue 15.40 11.35 8 42015 370 34914538
Streptococcal infection 15.38 11.35 24 41999 4937 34909971
Mast cell degranulation present 15.30 11.35 5 42018 68 34914840
C-reactive protein increased 15.22 11.35 26 41997 54072 34860836
Double inlet left ventricle 15.15 11.35 4 42019 24 34914884
Hyponatraemia 15.08 11.35 50 41973 82641 34832267
Hyperhidrosis 15.02 11.35 148 41875 75544 34839364
Sepsis 15.02 11.35 128 41895 166433 34748475
Product compounding quality issue 15.01 11.35 4 42019 25 34914883
Myocardial infarction 14.87 11.35 216 41807 120869 34794039
Product preparation error 14.76 11.35 16 42007 2301 34912607
Metastases to eye 14.73 11.35 5 42018 77 34914831
Lower respiratory tract infection 14.68 11.35 10 42013 31627 34883281
White blood cell count decreased 14.61 11.35 62 41961 95383 34819525
Pneumocystis jirovecii pneumonia 14.50 11.35 3 42020 19707 34895201
Drooling 14.36 11.35 19 42004 3363 34911545
Arthralgia 14.31 11.35 133 41890 169908 34745000
Post transplant distal limb syndrome 14.23 11.35 7 42016 288 34914620
Saccadic eye movement 14.18 11.35 6 42017 173 34914735
Hypoxic-ischaemic encephalopathy 14.16 11.35 22 42001 4510 34910398
Cardiac failure 14.14 11.35 59 41964 91189 34823719
Incision site pain 14.06 11.35 14 42009 1824 34913084
Impaired gastric emptying 14.05 11.35 19 42004 3434 34911474
Renal transplant 13.99 11.35 14 42009 1835 34913073
Skin induration 13.96 11.35 15 42008 2136 34912772
Pulmonary embolism 13.92 11.35 58 41965 89688 34825220
Productive cough 13.84 11.35 15 42008 37798 34877110
Transcription medication error 13.81 11.35 6 42017 185 34914723
Intentional product misuse 13.76 11.35 98 41925 45513 34869395
Univentricular heart 13.73 11.35 4 42019 36 34914872
Seizure 13.65 11.35 189 41834 104668 34810240
Autoimmune enteropathy 13.64 11.35 4 42019 37 34914871
Muscle spasticity 13.63 11.35 25 41998 5863 34909045
Device infusion issue 13.47 11.35 10 42013 875 34914033
Gastrointestinal tract mucosal pigmentation 13.46 11.35 8 42015 482 34914426
COVID-19 13.39 11.35 48 41975 77502 34837406
Skin tightness 13.39 11.35 15 42008 2238 34912670
Hydrocele male infected 13.36 11.35 4 42019 40 34914868
Drug withdrawal maintenance therapy 13.30 11.35 5 42018 105 34914803
Gastric hypomotility 13.17 11.35 5 42018 108 34914800
Pulmonary fibrosis 13.13 11.35 3 42020 18393 34896515
Sprue-like enteropathy 13.12 11.35 8 42015 505 34914403
Skin hypertrophy 13.11 11.35 16 42007 2613 34912295
Harlequin syndrome 13.03 11.35 3 42020 9 34914899
End stage renal disease 12.77 11.35 31 41992 8830 34906078
Septic shock 12.71 11.35 44 41979 71790 34843118
Contraindicated product administered 12.62 11.35 5 42018 21476 34893432
Product quality issue 12.53 11.35 47 41976 16988 34897920
Posterior reversible encephalopathy syndrome 12.45 11.35 33 41990 9921 34904987
Accident 12.41 11.35 22 42001 5025 34909883
Hypercapnia 12.39 11.35 20 42003 4235 34910673
Nephropathy 12.30 11.35 24 41999 5893 34909015
Alopecia 12.27 11.35 7 42016 24348 34890560
Impulsive behaviour 12.18 11.35 14 42009 2148 34912760
Multiple organ dysfunction syndrome 12.17 11.35 49 41974 76517 34838391
Liver disorder 12.17 11.35 13 42010 32984 34881924
Rash 11.98 11.35 192 41831 222560 34692348
Rash maculo-papular 11.91 11.35 10 42013 28441 34886467
Hepatitis 11.86 11.35 7 42016 23897 34891011
Arthropathy 11.84 11.35 9 42014 26898 34888010
Atrioventricular block first degree 11.81 11.35 24 41999 6068 34908840
Agranulocytosis 11.78 11.35 7 42016 23814 34891094
Mood swings 11.77 11.35 28 41995 7873 34907035
Renal artery stenosis 11.67 11.35 14 42009 2247 34912661
Drug withdrawal headache 11.66 11.35 3 42020 16 34914892
Lymphocele 11.63 11.35 11 42012 1346 34913562
Joint contracture 11.56 11.35 13 42010 1948 34912960
Hyperbilirubinaemia 11.52 11.35 3 42020 16840 34898068
Autism spectrum disorder 11.50 11.35 14 42009 2282 34912626
Disseminated intravascular coagulation 11.38 11.35 6 42017 21810 34893098

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 594.01 10.24 1018 88031 244749 79410590
Temperature regulation disorder 380.87 10.24 167 88882 5686 79649653
Bradycardia 350.16 10.24 579 88470 134978 79520361
Drug withdrawal syndrome 324.65 10.24 286 88763 34432 79620907
Food allergy 270.68 10.24 162 88887 10662 79644677
Coeliac disease 268.68 10.24 164 88885 11187 79644152
Hypertensive crisis 265.10 10.24 205 88844 20565 79634774
Hypertension 200.98 10.24 816 88233 330176 79325163
Immunodeficiency 187.03 10.24 171 88878 21597 79633742
Cardiac failure congestive 183.90 10.24 456 88593 141946 79513393
Mental status changes 175.40 10.24 288 88761 66671 79588668
Withdrawal hypertension 174.20 10.24 47 89002 337 79655002
Overdose 172.25 10.24 524 88525 183682 79471657
Bursitis 163.54 10.24 201 88848 35643 79619696
Hyperhidrosis 158.89 10.24 449 88600 151043 79504296
Aggression 155.37 10.24 235 88814 50723 79604616
Sinus bradycardia 144.33 10.24 159 88890 25088 79630251
Withdrawal syndrome 141.35 10.24 162 88887 26692 79628647
Respiratory depression 139.26 10.24 163 88886 27467 79627872
Hypotension 134.90 10.24 897 88152 439420 79215919
Accidental exposure to product by child 126.71 10.24 63 88986 2863 79652476
Synovitis 117.19 10.24 15 89034 150719 79504620
Toxicity to various agents 115.64 10.24 836 88213 420704 79234635
Somnolence 108.60 10.24 541 88508 238440 79416899
Cerebrovascular accident 108.02 10.24 400 88649 154892 79500447
Drug dependence 96.97 10.24 168 88881 40601 79614738
Poisoning 96.85 10.24 130 88919 25142 79630197
Miosis 92.96 10.24 101 88948 15688 79639651
Hand deformity 92.34 10.24 6 89043 103913 79551426
Paradoxical drug reaction 91.85 10.24 71 88978 7114 79648225
Body tinea 89.52 10.24 43 89006 1811 79653528
Cardiac arrest 89.35 10.24 405 88644 171691 79483648
Fluid retention 88.41 10.24 222 88827 69587 79585752
Arthropathy 87.78 10.24 44 89005 177067 79478272
Blood pressure inadequately controlled 87.72 10.24 65 88984 6112 79649227
Rash erythematous 87.54 10.24 197 88852 57572 79597767
Sedation 85.47 10.24 183 88866 51712 79603627
Hypertensive emergency 83.75 10.24 47 89002 2738 79652601
Neovascularisation 82.54 10.24 36 89013 1209 79654130
Oppositional defiant disorder 82.35 10.24 28 89021 469 79654870
Pemphigus 82.21 10.24 8 89041 99574 79555765
Victim of child abuse 81.40 10.24 33 89016 920 79654419
Malignant catatonia 80.21 10.24 27 89022 438 79654901
Respiratory arrest 77.08 10.24 187 88862 57363 79597976
Alopecia 75.74 10.24 88 88961 231267 79424072
Neutropenia 75.69 10.24 128 88921 287582 79367757
Agitation 73.66 10.24 262 88787 99453 79555886
Anti-cyclic citrullinated peptide antibody positive 73.28 10.24 5 89044 83138 79572201
Nephrogenic systemic fibrosis 72.55 10.24 58 88991 6102 79649237
Arthralgia 70.95 10.24 363 88686 571440 79083899
Joint swelling 70.03 10.24 135 88914 288511 79366828
Febrile neutropenia 69.21 10.24 94 88955 230905 79424434
Infection susceptibility increased 68.76 10.24 46 89003 3675 79651664
Pericarditis 68.70 10.24 16 89033 104220 79551119
Lethargy 68.30 10.24 223 88826 81069 79574270
Suspected suicide 68.19 10.24 71 88978 10505 79644834
Hypertensive encephalopathy 67.08 10.24 29 89020 953 79654386
Upper respiratory tract infection 66.87 10.24 239 88810 90929 79564410
Glossodynia 65.89 10.24 17 89032 103320 79552019
Blood pressure increased 64.78 10.24 431 88618 210929 79444410
Interstitial lung disease 63.73 10.24 23 89026 112577 79542762
Malignant neoplasm progression 62.69 10.24 37 89012 135953 79519386
Inhibitory drug interaction 61.32 10.24 46 89003 4407 79650932
Myocardial infarction 61.03 10.24 383 88666 183746 79471593
Decreased eye contact 60.58 10.24 26 89023 839 79654500
Systemic lupus erythematosus 60.16 10.24 30 89019 121119 79534220
Choreoathetosis 59.81 10.24 31 89018 1539 79653800
Unresponsive to stimuli 58.07 10.24 165 88884 55623 79599716
Epidural lipomatosis 57.84 10.24 28 89021 1200 79654139
Poor quality sleep 57.14 10.24 96 88953 22626 79632713
Drug intolerance 55.37 10.24 134 88915 263985 79391354
Homicidal ideation 55.07 10.24 39 89010 3418 79651921
Accidental overdose 54.49 10.24 130 88919 39451 79615888
Helicobacter infection 54.00 10.24 7 89042 69697 79585642
Application site pruritus 51.67 10.24 39 89010 3771 79651568
Lower respiratory tract infection 50.52 10.24 42 89007 129178 79526161
Glucose tolerance impaired 49.85 10.24 53 88996 8031 79647308
Infusion related reaction 49.69 10.24 115 88934 230122 79425217
Wound 48.93 10.24 35 89014 116144 79539195
Cardio-respiratory arrest 48.75 10.24 245 88804 108265 79547074
Rash 48.49 10.24 413 88636 577945 79077394
Diarrhoea 47.23 10.24 696 88353 879793 78775546
Drug ineffective for unapproved indication 46.17 10.24 144 88905 51094 79604245
Application site irritation 45.94 10.24 27 89022 1717 79653622
Application site rash 45.88 10.24 29 89020 2103 79653236
Therapeutic product effect decreased 45.79 10.24 70 88979 163793 79491546
Infection 45.79 10.24 129 88920 241583 79413756
Intentional product misuse 45.70 10.24 219 88830 94946 79560393
Maternal exposure during pregnancy 45.68 10.24 51 88998 136487 79518852
Trismus 45.11 10.24 42 89007 5425 79649914
Medical device site pain 45.04 10.24 16 89033 307 79655032
Swelling 44.58 10.24 111 88938 216600 79438739
C-reactive protein increased 44.48 10.24 47 89002 128980 79526359
Anxiety 44.24 10.24 448 88601 248064 79407275
Product tampering 44.20 10.24 17 89032 411 79654928
Rheumatoid factor positive 44.05 10.24 7 89042 59832 79595507
Duodenal ulcer perforation 43.95 10.24 10 89039 66201 79589138
Nasopharyngitis 42.07 10.24 144 88905 253737 79401602
Hepatic function abnormal 41.25 10.24 15 89034 73092 79582247
Pyrexia 41.20 10.24 523 88526 678186 78977153
Irritability 41.18 10.24 120 88929 41024 79614315
Peritonitis bacterial 40.99 10.24 52 88997 9515 79645824
Neuroleptic malignant syndrome 40.65 10.24 93 88956 27466 79627873
Acute motor-sensory axonal neuropathy 40.62 10.24 16 89033 413 79654926
Suicidal ideation 40.58 10.24 181 88868 76159 79579180
Constipation 39.76 10.24 487 88562 282563 79372776
Folliculitis 39.61 10.24 7 89042 55373 79599966
Implant site extravasation 39.56 10.24 19 89030 800 79654539
Blood prolactin increased 39.40 10.24 34 89015 3977 79651362
Toxic epidermal necrolysis 38.98 10.24 124 88925 44457 79610882
Adulterated product 38.87 10.24 14 89035 280 79655059
Condition aggravated 38.84 10.24 365 88684 500759 79154580
Obesity 38.63 10.24 106 88943 35019 79620320
Apnoea 38.56 10.24 56 88993 11648 79643691
Psoriatic arthropathy 37.70 10.24 20 89029 77979 79577360
Product substitution issue 37.54 10.24 75 88974 20181 79635158
Neutrophil count decreased 37.39 10.24 30 89019 93929 79561410
Crying 36.49 10.24 80 88969 22963 79632376
Impaired healing 36.14 10.24 27 89022 87628 79567711
Psychomotor hyperactivity 35.66 10.24 66 88983 16783 79638556
Intestinal angioedema 35.27 10.24 18 89031 865 79654474
Medication error 35.18 10.24 161 88888 68481 79586858
Malignant hypertension 34.75 10.24 22 89027 1600 79653739
Dystonia 34.69 10.24 75 88974 21324 79634015
Left ventricular hypertrophy 34.65 10.24 52 88997 11139 79644200
Coronary artery disease 34.62 10.24 155 88894 65319 79590020
Application site erythema 34.19 10.24 35 89014 5075 79650264
Hyperaesthesia 33.93 10.24 54 88995 12168 79643171
Catatonia 33.48 10.24 45 89004 8711 79646628
Anti-neutrophil cytoplasmic antibody positive vasculitis 33.41 10.24 30 89019 3699 79651640
Irritable bowel syndrome 33.09 10.24 14 89035 62227 79593112
Overweight 32.55 10.24 31 89018 4119 79651220
White blood cell count decreased 32.41 10.24 105 88944 188183 79467156
Gastrointestinal tract mucosal pigmentation 32.34 10.24 18 89031 1032 79654307
Sleep disorder due to general medical condition, insomnia type 32.27 10.24 5 89044 43551 79611788
Brain injury 32.13 10.24 51 88998 11466 79643873
Emotional distress 32.09 10.24 108 88941 39861 79615478
Hyperlipidaemia 32.00 10.24 82 88967 26011 79629328
Intentional product use issue 31.99 10.24 77 88972 152035 79503304
Claustrophobia 31.73 10.24 19 89030 1251 79654088
Sinusitis 31.62 10.24 112 88937 195389 79459950
Liver disorder 31.57 10.24 21 89028 72396 79582943
Arthritis 31.21 10.24 50 88999 114830 79540509
Discomfort 31.09 10.24 58 88991 125559 79529780
Loss of consciousness 30.46 10.24 304 88745 167639 79487700
Child abuse 30.39 10.24 13 89036 416 79654923
Bruxism 29.56 10.24 29 89020 3997 79651342
Kidney transplant rejection 29.45 10.24 46 89003 10200 79645139
Drug screen positive 29.27 10.24 35 89014 6028 79649311
Abdominal discomfort 28.88 10.24 163 88886 250564 79404775
Impaired quality of life 28.76 10.24 55 88994 14331 79641008
Chronic kidney disease 28.74 10.24 148 88901 66006 79589333
Acute myocardial infarction 28.53 10.24 165 88884 76871 79578468
Tardive dyskinesia 28.38 10.24 46 89003 10525 79644814
Disease progression 28.25 10.24 108 88941 184254 79471085
Skin hypertrophy 28.10 10.24 31 89018 4897 79650442
Osteonecrosis of jaw 27.76 10.24 7 89042 43219 79612120
Pneumonia 27.50 10.24 546 88503 659700 78995639
Hypoventilation 27.43 10.24 37 89012 7187 79648152
Product compounding quality issue 27.31 10.24 7 89042 40 79655299
Depressed level of consciousness 27.14 10.24 193 88856 96459 79558880
Aplastic anaemia 27.05 10.24 61 88988 17844 79637495
Skin induration 26.73 10.24 29 89020 4496 79650843
Tic 26.71 10.24 24 89025 2962 79652377
Bone density decreased 26.65 10.24 51 88998 13296 79642043
Posterior reversible encephalopathy syndrome 26.63 10.24 77 88972 26204 79629135
Anhedonia 26.22 10.24 54 88995 14844 79640495
Nodal rhythm 25.71 10.24 24 89025 3111 79652228
Inflammation 25.28 10.24 41 89008 93712 79561627
Medical device site discharge 25.27 10.24 7 89042 56 79655283
Asthma 25.20 10.24 246 88803 134849 79520490
Dyskinesia 25.19 10.24 108 88941 44665 79610674
Epilepsy with myoclonic-atonic seizures 25.12 10.24 8 89041 108 79655231
Back pain 25.08 10.24 478 88571 303702 79351637
Anal inflammation 24.81 10.24 17 89032 1413 79653926
Product adhesion issue 24.71 10.24 22 89027 2682 79652657
Autonomic nervous system imbalance 24.47 10.24 28 89021 4602 79650737
Renin decreased 24.47 10.24 8 89041 118 79655221
Akathisia 24.46 10.24 49 89000 13210 79642129
Product prescribing error 24.38 10.24 107 88942 44706 79610633
Anger 24.30 10.24 57 88992 17105 79638234
Pulse abnormal 24.15 10.24 24 89025 3360 79651979
Mood swings 23.89 10.24 62 88987 19818 79635521
Juvenile idiopathic arthritis 23.83 10.24 28 89021 4735 79650604
Thrombocytopenia 23.73 10.24 186 88863 265073 79390266
Extrapyramidal disorder 23.52 10.24 67 88982 22612 79632727
Basal ganglion degeneration 23.50 10.24 11 89038 437 79654902
Pneumocystis jirovecii pneumonia 23.49 10.24 4 89045 32504 79622835
Device infusion issue 23.42 10.24 20 89029 2306 79653033
Hypothermia 23.40 10.24 67 88982 22679 79632660
Intestinal pseudo-obstruction 23.39 10.24 21 89028 2588 79652751
Blood aldosterone increased 23.34 10.24 9 89040 219 79655120
Pulmonary fibrosis 23.32 10.24 10 89039 44102 79611237
Seizure 23.16 10.24 317 88732 188517 79466822
Leukopenia 22.93 10.24 61 88988 116452 79538887
Musculoskeletal stiffness 22.83 10.24 109 88940 174899 79480440
Primary hyperaldosteronism 22.79 10.24 8 89041 148 79655191
Anuria 22.79 10.24 63 88986 20900 79634439
Attention deficit hyperactivity disorder 22.75 10.24 23 89026 3286 79652053
COVID-19 22.49 10.24 95 88954 157579 79497760
Pancytopenia 22.35 10.24 102 88947 165643 79489696
Hepatitis 21.91 10.24 18 89031 55709 79599630
Anaesthesia 21.80 10.24 11 89038 516 79654823
Oromandibular dystonia 21.80 10.24 14 89035 1044 79654295
Application site discolouration 21.78 10.24 13 89036 851 79654488
Tissue infiltration 21.70 10.24 12 89037 679 79654660
Lymphopenia 21.55 10.24 4 89045 30553 79624786
Accelerated hypertension 21.53 10.24 12 89037 690 79654649
Loss of personal independence in daily activities 21.50 10.24 52 88997 102528 79552811
Abnormal behaviour 21.38 10.24 89 88960 36332 79619007
Neoplasm progression 21.20 10.24 16 89033 51666 79603673
Platelet count decreased 21.11 10.24 129 88920 194535 79460804
General physical health deterioration 21.05 10.24 201 88848 275037 79380302
Rash maculo-papular 20.97 10.24 19 89030 56059 79599280
Implant site infection 20.78 10.24 17 89032 1848 79653491
Tremor 20.64 10.24 285 88764 169798 79485541
Dialysis 20.58 10.24 56 88993 18406 79636933
Retrograde amnesia 20.37 10.24 11 89038 594 79654745
Neutropenic sepsis 20.30 10.24 3 89046 27061 79628278
Prostate cancer 20.22 10.24 6 89043 33262 79622077
Cancer pain 20.12 10.24 27 89022 5218 79650121
Somatic symptom disorder 19.99 10.24 19 89030 2518 79652821
Productive cough 19.95 10.24 43 89006 88288 79567051
Fibrosis 19.87 10.24 27 89022 5282 79650057
Acute myeloid leukaemia 19.84 10.24 5 89044 30880 79624459
Gastrointestinal disorder 19.76 10.24 70 88979 122135 79533204
Alanine aminotransferase increased 19.64 10.24 104 88945 162466 79492873
Haematochezia 19.52 10.24 43 89006 87602 79567737
Peripheral swelling 19.32 10.24 200 88849 269417 79385922
Device failure 19.25 10.24 29 89020 6232 79649107
Hyperreflexia 19.21 10.24 34 89015 8351 79646988
Insomnia 19.09 10.24 382 88667 244788 79410551
Foetal death 18.93 10.24 33 89016 8011 79647328
Urinary incontinence 18.81 10.24 93 88956 40816 79614523
Reaction to excipient 18.79 10.24 15 89034 1574 79653765
Atrioventricular block second degree 18.53 10.24 31 89018 7281 79648058
SARS-CoV-2 test negative 18.52 10.24 14 89035 1357 79653982
Norepinephrine increased 18.51 10.24 6 89043 86 79655253
Hypotonia 18.50 10.24 43 89006 12827 79642512
Drug withdrawal headache 18.44 10.24 6 89043 87 79655252
Skin disorder 18.43 10.24 81 88968 33862 79621477
Autism spectrum disorder 18.36 10.24 13 89036 1139 79654200
Osteoporosis 18.32 10.24 20 89029 54092 79601247
Atrioventricular block first degree 18.25 10.24 42 89007 12449 79642890
Colitis ulcerative 18.17 10.24 8 89041 34734 79620605
Respiratory moniliasis 18.06 10.24 8 89041 279 79655060
Device power source issue 18.02 10.24 12 89037 951 79654388
Sympathomimetic effect 17.79 10.24 6 89043 98 79655241
Pernicious anaemia 17.76 10.24 10 89039 586 79654753
Cytomegalovirus infection 17.75 10.24 13 89036 42631 79612708
Osteoarthritis 17.72 10.24 45 89004 87264 79568075
Injection site erythema 17.72 10.24 38 89011 78159 79577180
Purpura 17.70 10.24 55 88994 19472 79635867
Vascular stenosis 17.61 10.24 10 89039 596 79654743
Muscle contracture 17.59 10.24 17 89032 2300 79653039
Drug eruption 17.51 10.24 14 89035 43921 79611418
Product administered to patient of inappropriate age 17.47 10.24 26 89023 5527 79649812
Basal cell carcinoma 17.45 10.24 10 89039 37365 79617974
Bone marrow failure 17.18 10.24 19 89030 51088 79604251
Coma scale abnormal 17.13 10.24 33 89016 8645 79646694
Mood altered 16.86 10.24 51 88998 17796 79637543
Abortion spontaneous 16.74 10.24 6 89043 29501 79625838
Infusion site mass 16.66 10.24 14 89035 1579 79653760
Affect lability 16.61 10.24 38 89011 11221 79644118
Incision site pain 16.48 10.24 18 89031 2812 79652527
Injection site abscess 16.31 10.24 14 89035 1626 79653713
Cytokine release syndrome 16.29 10.24 10 89039 35988 79619351
Uterine enlargement 16.24 10.24 11 89038 897 79654442
Change in seizure presentation 16.22 10.24 9 89040 513 79654826
Corneal reflex decreased 16.14 10.24 8 89041 361 79654978
Rash pruritic 16.07 10.24 35 89014 71594 79583745
Melaena 16.07 10.24 27 89022 60863 79594476
Agranulocytosis 15.97 10.24 16 89033 45014 79610325
Pulse absent 15.91 10.24 35 89014 10068 79645271
Rheumatic fever 15.84 10.24 6 89043 28519 79626820
Serotonin syndrome 15.74 10.24 95 88954 44932 79610407
Respiratory rate decreased 15.72 10.24 24 89025 5219 79650120
Pain in jaw 15.69 10.24 17 89032 46134 79609205
Mast cell degranulation present 15.66 10.24 5 89044 68 79655271
Malaise 15.61 10.24 422 88627 489447 79165892
Hyperthyroidism 15.47 10.24 3 89046 22206 79633133
Medical device site infection 15.46 10.24 9 89040 562 79654777
Application site papules 15.34 10.24 5 89044 73 79655266
Hyperkinesia 15.27 10.24 17 89032 2712 79652627
Prescribed overdose 15.25 10.24 83 88966 37800 79617539
Chest discomfort 15.21 10.24 91 88958 137953 79517386
Labelled drug-drug interaction medication error 15.05 10.24 6 89043 27644 79627695
Speech disorder 14.87 10.24 108 88941 54337 79601002
Drooling 14.82 10.24 25 89024 5909 79649430
Saccadic eye movement 14.78 10.24 6 89043 168 79655171
Drug tolerance 14.75 10.24 31 89018 8644 79646695
Renal injury 14.72 10.24 47 89002 16880 79638459
Implant site discharge 14.68 10.24 6 89043 171 79655168
Gamma-glutamyltransferase increased 14.66 10.24 24 89025 54656 79600683
Iliac artery stenosis 14.51 10.24 6 89043 176 79655163
Pulmonary renal syndrome 14.51 10.24 9 89040 631 79654708
Blood potassium increased 14.50 10.24 68 88981 29207 79626132
Neurological symptom 14.49 10.24 31 89018 8752 79646587
Renal transplant 14.48 10.24 16 89033 2531 79652808
Brief psychotic disorder with marked stressors 14.42 10.24 7 89042 302 79655037
Cardiac hypertrophy 14.38 10.24 13 89036 1617 79653722
Mobility decreased 14.29 10.24 79 88970 122096 79533243
Pneumonitis 14.27 10.24 29 89020 60831 79594508
Glomerulonephritis rapidly progressive 14.26 10.24 13 89036 1635 79653704
Focal segmental glomerulosclerosis 14.15 10.24 18 89031 3303 79652036
Product preparation issue 13.95 10.24 12 89037 1398 79653941
Impaired work ability 13.92 10.24 51 88998 19630 79635709
Joint injury 13.77 10.24 9 89040 31326 79624013
Hyponatraemia 13.54 10.24 130 88919 177718 79477621
Hip arthroplasty 13.51 10.24 12 89037 35744 79619595
Renal artery stenosis 13.47 10.24 18 89031 3464 79651875
Hypoxic-ischaemic encephalopathy 13.36 10.24 28 89021 7792 79647547
Pulmonary oedema 13.31 10.24 154 88895 88100 79567239
Pruritus 13.08 10.24 338 88711 394310 79261029
Hepatic cytolysis 13.06 10.24 7 89042 27144 79628195
Hypertensive urgency 13.04 10.24 8 89041 550 79654789
Delirium 12.91 10.24 148 88901 84479 79570860
Multiple sclerosis relapse 12.87 10.24 20 89029 46513 79608826
Hypertrichosis 12.86 10.24 11 89038 1271 79654068
Bladder cancer 12.86 10.24 3 89046 19523 79635816
Human herpesvirus 6 infection reactivation 12.82 10.24 8 89041 567 79654772
Product prescribing issue 12.81 10.24 19 89030 4026 79651313
Product quality issue 12.76 10.24 73 88976 33867 79621472
Mydriasis 12.71 10.24 46 89003 17597 79637742
Drug detoxification 12.66 10.24 7 89042 396 79654943
Stress cardiomyopathy 12.58 10.24 34 89015 11132 79644207
End stage renal disease 12.57 10.24 36 89013 12184 79643155
Knee arthroplasty 12.53 10.24 18 89031 43230 79612109
Autoimmune enteropathy 12.49 10.24 4 89045 55 79655284
Contraindicated product administered 12.49 10.24 114 88935 157424 79497915
Educational problem 12.49 10.24 7 89042 407 79654932
Normochromic normocytic anaemia 12.43 10.24 27 89022 7700 79647639
Accidental poisoning 12.29 10.24 12 89037 1645 79653694
Mucosal erosion 12.22 10.24 14 89035 2304 79653035
Skin tightness 12.15 10.24 22 89027 5500 79649839
Peritoneal dialysis complication 12.05 10.24 14 89035 2340 79652999
Exposure during pregnancy 12.04 10.24 65 88984 101067 79554272
Device expulsion 11.96 10.24 7 89042 25854 79629485
Eczema 11.82 10.24 17 89032 40801 79614538
Hypersomnia 11.71 10.24 54 88995 23032 79632307
Tendonitis 11.68 10.24 6 89043 23824 79631515
Gun shot wound 11.66 10.24 10 89039 1160 79654179
Myelodysplastic syndrome 11.65 10.24 10 89039 30291 79625048
Myalgia 11.60 10.24 142 88907 185499 79469840
Pain 11.58 10.24 924 88125 702878 78952461
Sinus arrhythmia 11.56 10.24 13 89036 2097 79653242
Page kidney 11.55 10.24 4 89045 71 79655268
Grip strength decreased 11.49 10.24 5 89044 21864 79633475
Vision blurred 11.47 10.24 174 88875 105724 79549615
Adrenal insufficiency 11.45 10.24 9 89040 28478 79626861
Right ventricular failure 11.39 10.24 6 89043 23491 79631848
Blood bilirubin increased 11.34 10.24 37 89012 66195 79589144
Femur fracture 11.29 10.24 16 89033 38636 79616703
Joint contracture 11.26 10.24 14 89035 2510 79652829
Bone erosion 11.25 10.24 3 89046 17844 79637495
Skin fibrosis 11.23 10.24 11 89038 1513 79653826
Therapeutic drug monitoring analysis incorrectly performed 11.23 10.24 8 89041 708 79654631
Encephalomalacia 11.15 10.24 10 89039 1231 79654108
Ill-defined disorder 11.14 10.24 37 89012 65838 79589501
Aspartate aminotransferase increased 11.13 10.24 100 88949 138541 79516798
Medical device site erythema 11.11 10.24 4 89045 80 79655259
Medical device site swelling 11.01 10.24 4 89045 82 79655257
Gastric hypomotility 10.96 10.24 5 89044 187 79655152
Swollen joint count increased 10.90 10.24 6 89043 22921 79632418
Drug resistance 10.88 10.24 19 89030 42194 79613145
Renal transplant failure 10.88 10.24 12 89037 1895 79653444
Device programming error 10.86 10.24 5 89044 191 79655148
Peau d'orange 10.86 10.24 6 89043 339 79655000
Hyperbilirubinaemia 10.83 10.24 7 89042 24511 79630828
Psychogenic seizure 10.76 10.24 12 89037 1919 79653420
Nervousness 10.74 10.24 69 88980 33346 79621993
Pleural effusion 10.71 10.24 107 88942 145155 79510184
Labile hypertension 10.66 10.24 7 89042 542 79654797
Respiratory failure 10.65 10.24 271 88778 180640 79474699
Drug dependence, antepartum 10.62 10.24 3 89046 26 79655313
Gastric ileus 10.52 10.24 3 89046 27 79655312
Foot deformity 10.47 10.24 7 89042 24067 79631272
Toxic skin eruption 10.36 10.24 6 89043 22287 79633052
Electrocardiogram QRS complex prolonged 10.27 10.24 31 89018 10802 79644537
Left atrial dilatation 10.26 10.24 15 89034 3138 79652201
Blood creatinine increased 10.26 10.24 236 88813 154821 79500518

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C02AC01 CARDIOVASCULAR SYSTEM
ANTIHYPERTENSIVES
ANTIADRENERGIC AGENTS, CENTRALLY ACTING
Imidazoline receptor agonists
ATC C02LC01 CARDIOVASCULAR SYSTEM
ANTIHYPERTENSIVES
ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION
Imidazoline receptor agonists in combination with diuretics
ATC C02LC51 CARDIOVASCULAR SYSTEM
ANTIHYPERTENSIVES
ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION
Imidazoline receptor agonists in combination with diuretics
ATC N02CX02 NERVOUS SYSTEM
ANALGESICS
ANTIMIGRAINE PREPARATIONS
Other antimigraine preparations
ATC S01EA04 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Sympathomimetics in glaucoma therapy
FDA MoA N0000009918 Adrenergic alpha2-Agonists
FDA EPC N0000175554 Central alpha-2 Adrenergic Agonist
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D058647 Adrenergic alpha-2 Receptor Agonists
MeSH PA D000316 Adrenergic alpha-Agonists
MeSH PA D000700 Analgesics
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D013565 Sympatholytics
CHEBI has role CHEBI:35569 alpha-adrenergic agonists
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:66991 sympatholytic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Severe pain indication 76948002
Open-angle glaucoma indication 84494001 DOID:1067
Attention deficit hyperactivity disorder indication 406506008
Increased Intraocular Pressure after Ocular Procedure indication
Ocular hypertension off-label use 4210003 DOID:9282
Gilles de la Tourette's syndrome off-label use 5158005 DOID:11119
Pain off-label use 22253000
Diarrhea off-label use 62315008
Opioid withdrawal off-label use 87132004
Menopausal flushing off-label use 198436008
Smoking cessation assistance off-label use 384742004
Nicotine Withdrawal Symptoms off-label use
Anuria contraindication 2472002 DOID:2983
Hypercholesterolemia contraindication 13644009
Myocardial infarction contraindication 22298006 DOID:5844
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Hypokalemia contraindication 43339004
Diabetes mellitus type 2 contraindication 44054006 DOID:9352
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Tear film insufficiency contraindication 46152009
End stage renal disease contraindication 46177005 DOID:784
Diabetes mellitus type 1 contraindication 46635009 DOID:9744
Bradycardia contraindication 48867003
Sinus bradycardia contraindication 49710005
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Blood coagulation disorder contraindication 64779008 DOID:1247
Hypercalcemia contraindication 66931009 DOID:12678
Hypochloremic alkalosis contraindication 70134007
Decreased respiratory function contraindication 80954004
Oliguria contraindication 83128009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Magnetic resonance imaging contraindication 113091000
Perioperative care contraindication 133897009
Hypomagnesemia contraindication 190855004
Acute pancreatitis contraindication 197456007 DOID:2913
Atrioventricular block contraindication 233917008 DOID:0050820
Labor pain contraindication 247412007
Raynaud's phenomenon contraindication 266261006
Syncope contraindication 271594007
Surgical procedure contraindication 387713003
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Myocardial ischemia contraindication 414795007 DOID:3393
Inflammatory dermatosis contraindication 703938007
Vagal Reflex Bradycardia contraindication
Severe Cardiopulmonary Disease contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.5 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Alpha-2B adrenergic receptor GPCR AGONIST Ki 7.50 CHEMBL CHEMBL
Alpha-2C adrenergic receptor GPCR AGONIST EC50 6.70 WOMBAT-PK CHEMBL
Alpha-2A adrenergic receptor GPCR AGONIST Ki 8.42 CHEMBL CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 6.22 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 6.50 PDSP
Nischarin Membrane receptor Ki 8.05 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 4.65 CHEMBL
Solute carrier family 22 member 2 Transporter IC50 4.80 WOMBAT-PK
Multidrug and toxin extrusion protein 1 Transporter IC50 4.48 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 5.49 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 6.50 PDSP
Alpha-1B adrenergic receptor GPCR Ki 5.99 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR Kd 6.59 CHEMBL
Alpha-2B adrenergic receptor GPCR Ki 8.08 CHEMBL
Alpha-1D adrenergic receptor GPCR AGONIST Ki 6.90 IUPHAR
5-hydroxytryptamine receptor 1A GPCR IC50 5.27 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 9.41 CHEMBL
Alpha-1A adrenergic receptor GPCR EC50 7.05 CHEMBL
Alpha-2A adrenergic receptor GPCR IC50 8.70 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 4.40 CHEMBL
Nischarin Unclassified Ki 6.95 CHEMBL
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Ion channel BLOCKER IC50 4.40 IUPHAR
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Ion channel BLOCKER IC50 5.10 IUPHAR
Adrenergic receptor alpha-2 GPCR Ki 8.82 CHEMBL
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Ion channel BLOCKER IC50 5 IUPHAR
Alpha-1B adrenergic receptor GPCR EC50 7.08 CHEMBL

External reference:

IDSource
4017850 VUID
N0000146207 NUI
D00281 KEGG_DRUG
4205-91-8 SECONDARY_CAS_RN
142432 RXNORM
4017849 VANDF
4017850 VANDF
C0009014 UMLSCUI
CHEBI:46631 CHEBI
CLU PDB_CHEM_ID
CHEMBL134 ChEMBL_ID
DB00575 DRUGBANK_ID
CHEMBL1705 ChEMBL_ID
D003000 MESH_DESCRIPTOR_UI
2803 PUBCHEM_CID
516 IUPHAR_LIGAND_ID
2624 INN_ID
MN3L5RMN02 UNII
27687 MMSL
381 MMSL
4478 MMSL
4479 MMSL
89106 MMSL
d00044 MMSL
000644 NDDF
004495 NDDF
372805007 SNOMEDCT_US
387121001 SNOMEDCT_US
62782004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Clonidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9723 INJECTION, SOLUTION 500 ug INTRAVENOUS ANDA 21 sections
Clonidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9723 INJECTION, SOLUTION 500 ug INTRAVENOUS ANDA 21 sections
Clonidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9724 INJECTION, SOLUTION 100 ug INTRAVENOUS ANDA 21 sections
Clonidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9724 INJECTION, SOLUTION 100 ug INTRAVENOUS ANDA 21 sections
Clonidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2127 TABLET 0.10 mg ORAL ANDA 12 sections
Clonidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2127 TABLET 0.10 mg ORAL ANDA 12 sections
Clonidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2128 TABLET 0.20 mg ORAL ANDA 12 sections
Clonidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2128 TABLET 0.20 mg ORAL ANDA 12 sections
Clonidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2129 TABLET 0.30 mg ORAL ANDA 12 sections
Clonidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2129 TABLET 0.30 mg ORAL ANDA 12 sections
Clonidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-4241 TABLET, EXTENDED RELEASE 0.10 mg ORAL ANDA 19 sections
Clonidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-4241 TABLET, EXTENDED RELEASE 0.10 mg ORAL ANDA 19 sections
Clonidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-4241 TABLET, EXTENDED RELEASE 0.10 mg ORAL ANDA 19 sections
Clonidine HUMAN PRESCRIPTION DRUG LABEL 1 0378-0871 PATCH 0.10 mg TRANSDERMAL ANDA 17 sections
Clonidine HUMAN PRESCRIPTION DRUG LABEL 1 0378-0871 PATCH 0.10 mg TRANSDERMAL ANDA 17 sections
Clonidine HUMAN PRESCRIPTION DRUG LABEL 1 0378-0872 PATCH 0.20 mg TRANSDERMAL ANDA 17 sections
Clonidine HUMAN PRESCRIPTION DRUG LABEL 1 0378-0872 PATCH 0.20 mg TRANSDERMAL ANDA 17 sections
Clonidine HUMAN PRESCRIPTION DRUG LABEL 1 0378-0873 PATCH 0.30 mg TRANSDERMAL ANDA 17 sections
Clonidine HUMAN PRESCRIPTION DRUG LABEL 1 0378-0873 PATCH 0.30 mg TRANSDERMAL ANDA 17 sections
Clonidine transdermal system HUMAN PRESCRIPTION DRUG LABEL 1 0591-3508 PATCH 0.10 mg TRANSDERMAL ANDA 21 sections
Clonidine transdermal system HUMAN PRESCRIPTION DRUG LABEL 1 0591-3508 PATCH 0.10 mg TRANSDERMAL ANDA 21 sections
Clonidine transdermal system HUMAN PRESCRIPTION DRUG LABEL 1 0591-3509 PATCH 0.20 mg TRANSDERMAL ANDA 21 sections
Clonidine transdermal system HUMAN PRESCRIPTION DRUG LABEL 1 0591-3509 PATCH 0.20 mg TRANSDERMAL ANDA 21 sections
Clonidine transdermal system HUMAN PRESCRIPTION DRUG LABEL 1 0591-3510 PATCH 0.30 mg TRANSDERMAL ANDA 21 sections
Clonidine transdermal system HUMAN PRESCRIPTION DRUG LABEL 1 0591-3510 PATCH 0.30 mg TRANSDERMAL ANDA 21 sections
Catapres-TTS HUMAN PRESCRIPTION DRUG LABEL 1 0597-0031 PATCH 0.10 mg TRANSDERMAL NDA 23 sections
Catapres-TTS HUMAN PRESCRIPTION DRUG LABEL 1 0597-0031 PATCH 0.10 mg TRANSDERMAL NDA 23 sections
Catapres-TTS HUMAN PRESCRIPTION DRUG LABEL 1 0597-0032 PATCH 0.20 mg TRANSDERMAL NDA 23 sections
Catapres-TTS HUMAN PRESCRIPTION DRUG LABEL 1 0597-0032 PATCH 0.20 mg TRANSDERMAL NDA 23 sections
Catapres-TTS HUMAN PRESCRIPTION DRUG LABEL 1 0597-0033 PATCH 0.30 mg TRANSDERMAL NDA 23 sections