clonazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 703 1622-61-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clonazepam
  • lonazep
  • klonopin
An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
  • Molecular weight: 315.71
  • Formula: C15H10ClN3O3
  • CLOGP: 2.38
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 87.28
  • ALOGS: -4.47
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
8 mg O
8 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.42 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 98 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.90 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.88 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.15 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 38 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
June 4, 1975 FDA ROCHE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2406.03 10.16 2674 206929 142999 63136420
Toxicity to various agents 930.38 10.16 2325 207278 244925 63034494
Suicide attempt 771.40 10.16 978 208625 59940 63219479
Drug abuse 593.09 10.16 945 208658 71573 63207846
Contraindicated product administered 578.90 10.16 35 209568 217613 63061806
Synovitis 543.52 10.16 16 209587 186902 63092517
Intentional overdose 534.63 10.16 913 208690 73239 63206180
Suicidal ideation 504.29 10.16 809 208794 61612 63217807
Systemic lupus erythematosus 467.43 10.16 67 209536 208851 63070568
Somnolence 464.86 10.16 1471 208132 177214 63102205
Respiratory arrest 457.94 10.16 552 209051 32093 63247326
Seizure 448.02 10.16 1199 208404 131435 63147984
Hand deformity 432.03 10.16 23 209580 159434 63119985
Depression 429.94 10.16 1526 208077 194966 63084453
Glossodynia 410.46 10.16 53 209550 178823 63100596
Drug intolerance 406.63 10.16 259 209344 308402 62971017
Cardio-respiratory arrest 396.71 10.16 711 208892 59248 63220171
Sopor 390.89 10.16 422 209181 21742 63257677
Arthropathy 358.87 10.16 163 209440 234629 63044790
Overdose 357.41 10.16 1009 208594 114069 63165350
Drug withdrawal syndrome 357.40 10.16 445 209158 26749 63252670
Psychotic disorder 351.21 10.16 429 209174 25283 63254136
Pericarditis 347.18 10.16 22 209581 131557 63147862
Infusion related reaction 338.65 10.16 195 209408 245326 63034093
Anxiety 316.28 10.16 1489 208114 216052 63063367
Joint swelling 304.34 10.16 381 209222 327285 62952134
Rheumatoid arthritis 292.52 10.16 245 209358 253574 63025845
Treatment failure 278.84 10.16 155 209448 198888 63080531
Cardiac arrest 275.20 10.16 799 208804 91746 63187673
Tremor 272.81 10.16 1008 208595 131231 63148188
Wound 272.70 10.16 99 209504 163164 63116255
Helicobacter infection 265.79 10.16 9 209594 92776 63186643
Alopecia 265.63 10.16 441 209162 337095 62942324
Swelling 264.31 10.16 312 209291 275066 63004353
Abdominal discomfort 253.64 10.16 418 209185 320467 62958952
Schizophrenia 252.47 10.16 231 209372 9721 63269698
Stubbornness 251.41 10.16 79 209524 292 63279127
Rash 247.37 10.16 984 208619 559887 62719532
Rheumatoid factor positive 246.05 10.16 7 209596 84399 63195020
Drug dependence 239.58 10.16 347 209256 24136 63255283
Irritability 230.58 10.16 392 209211 31302 63248117
Hypersensitivity 225.96 10.16 387 209216 292298 62987121
Panic attack 217.78 10.16 316 209287 22015 63257404
Agitation 206.37 10.16 545 209058 59212 63220207
Intentional self-injury 196.58 10.16 325 209278 25362 63254057
Serotonin syndrome 192.03 10.16 342 209261 28340 63251079
Maternal exposure during pregnancy 186.80 10.16 273 209330 219789 63059630
Abnormal behaviour 183.00 10.16 285 209318 21141 63258278
Poisoning 182.89 10.16 226 209377 13474 63265945
Folliculitis 181.79 10.16 13 209590 70304 63209115
Sensitisation 180.79 10.16 122 209481 3264 63276155
Discomfort 177.85 10.16 174 209429 167200 63112219
Infection 176.81 10.16 303 209300 228870 63050549
Therapeutic product effect decreased 175.66 10.16 228 209375 192959 63086460
Neuroleptic malignant syndrome 174.17 10.16 207 209396 11849 63267570
Muscle injury 172.09 10.16 11 209592 65334 63214085
Acute kidney injury 171.49 10.16 385 209218 263030 63016389
Withdrawal syndrome 169.41 10.16 265 209338 19732 63259687
General physical health deterioration 168.82 10.16 252 209351 201150 63078269
Stomatitis 168.35 10.16 127 209476 138598 63140821
Polycystic ovaries 167.62 10.16 130 209473 4341 63275078
Unresponsive to stimuli 158.29 10.16 347 209256 33469 63245950
Thinking abnormal 157.50 10.16 185 209418 10458 63268961
Insomnia 157.18 10.16 1232 208371 214020 63065399
Dyskinesia 155.06 10.16 333 209270 31669 63247750
Mental disorder 153.31 10.16 293 209310 25626 63253793
Ejection fraction 151.20 10.16 96 209507 2310 63277109
Anger 148.13 10.16 194 209409 12262 63267157
Rhinitis allergic 147.85 10.16 188 209415 11539 63267880
Drug interaction 144.07 10.16 1268 208335 227863 63051556
Arthralgia 143.59 10.16 1198 208405 568512 62710907
Febrile neutropenia 142.99 10.16 109 209494 118340 63161079
Impaired healing 141.85 10.16 81 209522 102461 63176958
Mood altered 139.94 10.16 206 209397 14537 63264882
Tardive dyskinesia 134.56 10.16 153 209450 8349 63271070
Hepatic enzyme increased 131.39 10.16 296 209307 202032 63077387
Mania 130.90 10.16 182 209421 12185 63267234
Aggression 129.69 10.16 258 209345 23240 63256179
Speech disorder 129.67 10.16 360 209243 40269 63239150
Rheumatic fever 127.80 10.16 3 209600 43108 63236311
Drug hypersensitivity 125.50 10.16 563 209040 310124 62969295
Disturbance in attention 125.48 10.16 342 209261 37847 63241572
Depressed level of consciousness 125.21 10.16 470 209133 61608 63217811
Crying 124.89 10.16 253 209350 23090 63256329
Ataxia 124.06 10.16 198 209405 14997 63264422
Dystonia 123.89 10.16 188 209415 13631 63265788
Intentional product misuse 121.86 10.16 460 209143 60457 63218962
Balance disorder 117.44 10.16 571 209032 83851 63195568
Feeling abnormal 115.87 10.16 863 208740 147529 63131890
Hyperhidrosis 115.02 10.16 678 208925 107158 63172261
Nightmare 114.77 10.16 218 209385 18976 63260443
Off label use 114.46 10.16 1555 208048 672907 62606512
Anaemia 110.10 10.16 546 209057 292884 62986535
Lower respiratory tract infection 109.41 10.16 167 209436 132140 63147279
Restless legs syndrome 107.77 10.16 208 209395 18323 63261096
Myoglobin urine present 107.37 10.16 52 209551 720 63278699
Dysarthria 105.69 10.16 346 209257 42365 63237054
Nervousness 103.34 10.16 279 209324 30700 63248719
Irritable bowel syndrome 101.82 10.16 74 209529 82338 63197081
Paranoia 100.63 10.16 156 209447 11523 63267896
Hallucination 99.93 10.16 402 209201 54415 63225004
Drug ineffective 99.60 10.16 2660 206943 1042105 62237314
Drooling 98.53 10.16 90 209513 3778 63275641
Sedation 98.38 10.16 317 209286 38492 63240927
Dissociation 96.85 10.16 79 209524 2840 63276579
Peripheral swelling 96.25 10.16 501 209102 265441 63013978
Feeling of despair 94.25 10.16 71 209532 2268 63277151
Muscle rigidity 94.09 10.16 150 209453 11350 63268069
Mydriasis 93.80 10.16 153 209450 11803 63267616
Jaundice cholestatic 93.25 10.16 118 209485 7206 63272213
Thrombocytopenia 92.61 10.16 228 209375 150929 63128490
Gastric pH decreased 92.42 10.16 47 209556 727 63278692
Sleep disorder due to general medical condition, insomnia type 91.75 10.16 29 209574 52188 63227231
Product use issue 90.55 10.16 397 209206 220123 63059296
Multiple sclerosis 89.99 10.16 228 209375 24144 63255275
Diarrhoea 89.54 10.16 1745 207858 713621 62565798
Neutropenia 88.76 10.16 289 209314 174716 63104703
Gastrointestinal disorder 88.45 10.16 188 209415 131051 63148368
Atrial fibrillation 88.23 10.16 156 209447 116480 63162939
Disease progression 86.85 10.16 171 209432 122587 63156832
Amnesia 86.12 10.16 388 209215 55197 63224222
Drug withdrawal convulsions 84.95 10.16 55 209548 1370 63278049
Cogwheel rigidity 84.31 10.16 62 209541 1908 63277511
Mood swings 82.84 10.16 185 209418 18063 63261356
Urinary tract discomfort 81.51 10.16 41 209562 619 63278800
Hypersomnia 79.68 10.16 181 209422 17874 63261545
Memory impairment 79.46 10.16 603 209000 103655 63175764
Sleep apnoea syndrome 79.38 10.16 244 209359 28889 63250530
Hip arthroplasty 79.30 10.16 29 209574 47617 63231802
Loss of consciousness 78.48 10.16 662 208941 117459 63161960
Bipolar disorder 78.12 10.16 113 209490 7847 63271572
Restlessness 77.77 10.16 244 209359 29209 63250210
Multiple sclerosis relapse 77.06 10.16 341 209262 48137 63231282
Derealisation 75.41 10.16 48 209555 1160 63278259
Multiple-drug resistance 75.06 10.16 89 209514 5081 63274338
Hallucination, auditory 74.64 10.16 144 209459 12680 63266739
Product substitution issue 73.55 10.16 163 209440 15833 63263586
Carpal tunnel syndrome 72.99 10.16 191 209412 20626 63258793
Ill-defined disorder 72.69 10.16 98 209505 81657 63197762
Malignant neoplasm progression 72.45 10.16 99 209504 82022 63197397
Psoriatic arthropathy 72.34 10.16 119 209484 91401 63188018
Alveolar osteitis 72.18 10.16 42 209561 859 63278560
Nasopharyngitis 71.12 10.16 519 209084 253738 63025681
Blood test abnormal 70.45 10.16 158 209445 15471 63263948
Tunnel vision 70.20 10.16 46 209557 1170 63278249
Liver injury 70.11 10.16 58 209545 60462 63218957
Bradyphrenia 69.84 10.16 100 209503 6880 63272539
Blister 69.60 10.16 209 209394 129605 63149814
Emotional disorder 68.02 10.16 142 209461 13237 63266182
Vision blurred 68.00 10.16 528 209075 91396 63188023
Knee arthroplasty 67.83 10.16 48 209555 54158 63225261
Coma 67.51 10.16 403 209200 63961 63215458
Hypokinesia 67.48 10.16 145 209458 13791 63265628
Hypoaesthesia oral 67.05 10.16 139 209464 12894 63266525
Sepsis 66.95 10.16 269 209334 152854 63126565
Head injury 66.93 10.16 221 209382 27175 63252244
Mobility decreased 66.45 10.16 193 209410 120966 63158453
Myelosuppression 65.48 10.16 3 209600 23700 63255719
Delusion 65.18 10.16 131 209472 11886 63267533
Toxic encephalopathy 63.99 10.16 93 209510 6486 63272933
Lethargy 63.51 10.16 358 209245 55649 63223770
Pleural effusion 63.23 10.16 133 209470 93077 63186342
Disorientation 63.08 10.16 278 209325 39174 63240245
Burning sensation 61.84 10.16 348 209255 54059 63225360
Movement disorder 61.44 10.16 184 209419 21477 63257942
Gait disturbance 61.20 10.16 896 208707 182282 63097137
C-reactive protein increased 61.06 10.16 139 209464 94568 63184851
Mental status changes 61.02 10.16 276 209327 39323 63240096
Status epilepticus 60.99 10.16 147 209456 15086 63264333
Pancytopenia 60.30 10.16 145 209458 96788 63182631
H1N1 influenza 59.68 10.16 48 209555 1691 63277728
Interstitial lung disease 59.42 10.16 70 209533 61838 63217581
Bladder pain 59.37 10.16 54 209549 2254 63277165
Animal scratch 59.27 10.16 44 209559 1374 63278045
Renal impairment 59.16 10.16 127 209476 88228 63191191
Akathisia 58.58 10.16 107 209496 9039 63270380
Depersonalisation/derealisation disorder 58.31 10.16 43 209560 1329 63278090
Respiratory depression 57.78 10.16 135 209468 13580 63265839
Pulmonary fibrosis 57.13 10.16 30 209573 39779 63239640
Drug screen negative 57.03 10.16 25 209578 271 63279148
Nephrectomy 56.86 10.16 44 209559 1464 63277955
Nasal polyps 56.76 10.16 84 209519 5955 63273464
Incontinence 56.29 10.16 121 209482 11511 63267908
Fall 56.28 10.16 1694 207909 390640 62888779
Mucosal inflammation 55.57 10.16 44 209559 46884 63232535
Epilepsy 55.45 10.16 206 209397 26859 63252560
Stress 55.45 10.16 396 209207 66771 63212648
On and off phenomenon 55.35 10.16 47 209556 1788 63277631
Sleep disorder due to a general medical condition 54.69 10.16 123 209480 12065 63267354
Exposure via ingestion 54.12 10.16 57 209546 2852 63276567
Bradykinesia 52.90 10.16 75 209528 5113 63274306
Ejection fraction abnormal 52.38 10.16 45 209558 1740 63277679
Musculoskeletal stiffness 52.00 10.16 376 209227 184242 63095177
Myocardial stunning 51.69 10.16 20 209583 153 63279266
Migraine 51.54 10.16 545 209058 102801 63176618
Electrocardiogram QT prolonged 51.50 10.16 355 209248 59175 63220244
Heart rate increased 51.31 10.16 506 209097 93732 63185687
Gastrointestinal haemorrhage 50.83 10.16 121 209482 81055 63198364
Abnormal dreams 50.44 10.16 109 209494 10407 63269012
Depressed mood 50.35 10.16 264 209339 39927 63239492
Therapeutic response unexpected 50.07 10.16 156 209447 18603 63260816
Intentional product use issue 49.61 10.16 235 209368 127657 63151762
Granulocytopenia 49.20 10.16 76 209527 5596 63273823
Feeling of body temperature change 48.76 10.16 70 209533 4827 63274592
Hyperprolactinaemia 48.33 10.16 62 209541 3838 63275581
Substance abuse 48.29 10.16 69 209534 4738 63274681
Major depression 47.85 10.16 91 209512 7927 63271492
Sluggishness 47.68 10.16 72 209531 5197 63274222
Parkinsonism 47.57 10.16 106 209497 10333 63269086
Pain 47.02 10.16 1984 207619 738644 62540775
Inflammation 45.87 10.16 130 209473 82143 63197276
Pneumonia aspiration 45.43 10.16 230 209373 34310 63245109
Asthma-chronic obstructive pulmonary disease overlap syndrome 44.94 10.16 44 209559 2017 63277402
Blood creatine phosphokinase increased 44.59 10.16 209 209394 30221 63249198
Adverse drug reaction 44.41 10.16 126 209477 79588 63199831
Paranasal sinus discomfort 44.23 10.16 63 209540 4313 63275106
Platelet count decreased 44.09 10.16 215 209388 115907 63163512
Muscle spasms 43.86 10.16 742 208861 155408 63124011
Dysphoria 43.72 10.16 67 209536 4899 63274520
Pleurothotonus 43.69 10.16 36 209567 1313 63278106
Decorticate posture 43.67 10.16 21 209582 286 63279133
Bone marrow failure 43.64 10.16 21 209582 29269 63250150
Hypercalcaemia 42.67 10.16 20 209583 28302 63251117
Influenza like illness 42.51 10.16 371 209232 66453 63212966
Galactorrhoea 42.26 10.16 60 209543 4095 63275324
Myocardial depression 41.72 10.16 24 209579 480 63278939
Menstrual disorder 41.69 10.16 68 209535 5245 63274174
Generalised tonic-clonic seizure 41.58 10.16 198 209405 28818 63250601
Aphasia 41.50 10.16 217 209386 32783 63246636
Neutrophil count decreased 41.25 10.16 77 209526 56329 63223090
Broncholithiasis 41.20 10.16 19 209584 234 63279185
Urinary retention 40.01 10.16 202 209401 30099 63249320
Skin ulcer 39.90 10.16 50 209553 42995 63236424
Personality disorder 39.80 10.16 70 209533 5741 63273678
Musculoskeletal pain 39.75 10.16 163 209440 92114 63187305
Emotional distress 39.54 10.16 212 209391 32337 63247082
Cardiac failure 39.32 10.16 156 209447 88986 63190433
Cholelithiasis 39.22 10.16 264 209339 43661 63235758
Amylase increased 39.09 10.16 73 209530 6272 63273147
Therapeutic product ineffective 38.96 10.16 38 209565 1734 63277685
Atonic seizures 38.92 10.16 25 209578 614 63278805
Stoma site discharge 38.41 10.16 36 209567 1562 63277857
Hallucinations, mixed 38.15 10.16 62 209541 4767 63274652
Lactic acidosis 38.14 10.16 42 209561 38245 63241174
Drug tolerance decreased 38.11 10.16 6 209597 17467 63261952
Melaena 37.84 10.16 27 209576 30338 63249081
Nystagmus 37.62 10.16 71 209532 6149 63273270
Fear 37.46 10.16 126 209477 15640 63263779
Breast hyperplasia 37.41 10.16 19 209584 293 63279126
Middle insomnia 37.38 10.16 109 209494 12534 63266885
Miosis 37.33 10.16 78 209525 7275 63272144
Electroencephalogram abnormal 37.31 10.16 53 209550 3619 63275800
Dopamine dysregulation syndrome 37.28 10.16 16 209587 164 63279255
Asthma 37.23 10.16 610 208993 126951 63152468
Hostility 37.20 10.16 38 209565 1834 63277585
Impaired driving ability 37.12 10.16 59 209544 4452 63274967
Macular degeneration 37.05 10.16 17 209586 24359 63255060
Rubber sensitivity 36.97 10.16 42 209561 2289 63277130
Blood creatinine increased 36.71 10.16 157 209446 87687 63191732
Palmar-plantar erythrodysaesthesia syndrome 36.65 10.16 15 209588 23000 63256419
Psychomotor hyperactivity 36.53 10.16 97 209506 10566 63268853
Bronchopulmonary aspergillosis allergic 36.35 10.16 41 209562 2217 63277202
Drug screen positive 36.32 10.16 52 209551 3577 63275842
Lymph node calcification 36.30 10.16 19 209584 313 63279106
Catatonia 36.08 10.16 58 209545 4419 63275000
Red blood cell sedimentation rate increased 35.87 10.16 56 209547 43926 63235493
Sinus pain 35.81 10.16 50 209553 3360 63276059
Coma blister 35.72 10.16 15 209588 145 63279274
Libido increased 35.64 10.16 32 209571 1313 63278106
Cardiac disorder 35.43 10.16 288 209315 50528 63228891
Drug use disorder 35.39 10.16 61 209542 4923 63274496
Dizziness 35.04 10.16 1745 207858 428180 62851239
Sleep-related eating disorder 34.66 10.16 26 209577 825 63278594
Product complaint 34.63 10.16 107 209496 12702 63266717
Bone erosion 34.58 10.16 8 209595 17709 63261710
Hyperkalaemia 34.57 10.16 80 209523 54123 63225296
Septic shock 34.47 10.16 109 209494 66520 63212899
Ear congestion 34.41 10.16 44 209559 2715 63276704
Live birth 34.36 10.16 21 209582 25609 63253810
Pneumocystis jirovecii pneumonia 34.31 10.16 7 209596 16907 63262512
Incoherent 34.23 10.16 57 209546 4473 63274946
Muscle disorder 34.22 10.16 60 209543 4909 63274510
Hypothyroidism 33.83 10.16 249 209354 42383 63237036
Suspected suicide 33.73 10.16 70 209533 6498 63272921
Osmolar gap increased 33.54 10.16 13 209590 100 63279319
Hypoventilation 33.51 10.16 58 209545 4696 63274723
Urinary incontinence 33.27 10.16 200 209403 31814 63247605
Limb injury 33.05 10.16 169 209434 25308 63254111
Oromandibular dystonia 33.05 10.16 21 209582 506 63278913
Herpes zoster 32.87 10.16 150 209453 82312 63197107
Decompression sickness 32.68 10.16 12 209591 78 63279341
Oropharyngeal oedema 32.63 10.16 18 209585 331 63279088
Persecutory delusion 32.47 10.16 43 209560 2747 63276672
Osteonecrosis of jaw 32.34 10.16 41 209562 35082 63244337
Total lung capacity increased 32.28 10.16 39 209564 2271 63277148
Nasal oedema 32.27 10.16 32 209571 1490 63277929
Mutism 32.23 10.16 33 209570 1597 63277822
Exposure during pregnancy 32.17 10.16 343 209260 155204 63124215
Autonomic nervous system imbalance 32.13 10.16 43 209560 2775 63276644
Cardiac failure congestive 31.79 10.16 177 209426 92256 63187163
Angioedema 31.23 10.16 70 209533 47895 63231524
Tension 31.05 10.16 45 209558 3130 63276289
Pruritus 30.63 10.16 934 208669 360519 62918900
Parosmia 30.54 10.16 65 209538 6141 63273278
Forced expiratory volume decreased 30.41 10.16 57 209546 4911 63274508
Weight increased 30.37 10.16 1099 208504 259693 63019726
Bruxism 30.25 10.16 47 209556 3478 63275941
Secretion discharge 30.17 10.16 99 209504 12132 63267287
Feeling jittery 29.99 10.16 105 209498 13298 63266121
Dysphagia 29.82 10.16 434 209169 88151 63191268
Extrapyramidal disorder 29.67 10.16 104 209499 13180 63266239
Liver function test increased 29.49 10.16 39 209564 32772 63246647
Post-traumatic stress disorder 29.39 10.16 58 209545 5193 63274226
Adjustment disorder with mixed anxiety and depressed mood 29.33 10.16 12 209591 108 63279311
Obsessive-compulsive disorder 29.23 10.16 50 209553 4010 63275409
Hypocalcaemia 29.22 10.16 37 209566 31676 63247743
Ketosis-prone diabetes mellitus 29.00 10.16 8 209595 16 63279403
Developmental glaucoma 28.94 10.16 10 209593 53 63279366
Creatinine renal clearance decreased 28.75 10.16 9 209594 16299 63263120
Dyspnoea 28.46 10.16 1842 207761 659471 62619948
Cytomegalovirus infection 28.32 10.16 17 209586 20935 63258484
Peripheral venous disease 28.27 10.16 8 209595 15469 63263950
Panic disorder 28.24 10.16 39 209564 2594 63276825
Suicidal behaviour 28.17 10.16 39 209564 2600 63276819
Rash pruritic 28.09 10.16 102 209501 59697 63219722
Plasma cell myeloma 28.07 10.16 47 209556 35858 63243561
Muscle twitching 28.03 10.16 134 209469 19534 63259885
Anticonvulsant drug level above therapeutic 28 10.16 19 209584 513 63278906
Lupus-like syndrome 27.76 10.16 8 209595 15287 63264132
Polymyalgia rheumatica 27.71 10.16 47 209556 3744 63275675
Dysgraphia 27.46 10.16 43 209560 3203 63276216
Freezing phenomenon 27.45 10.16 27 209576 1245 63278174
Therapy non-responder 27.39 10.16 143 209460 75758 63203661
Euphoric mood 27.37 10.16 54 209549 4833 63274586
Neutropenic sepsis 27.36 10.16 10 209593 16428 63262991
Neoplasm progression 27.28 10.16 49 209554 36379 63243040
Formication 27.23 10.16 50 209553 4241 63275178
Blood urine present 27.04 10.16 110 209493 14959 63264460
Troponin increased 26.86 10.16 84 209519 10037 63269382
Wound complication 26.79 10.16 46 209557 3701 63275718
Gastrooesophageal reflux disease 26.67 10.16 454 209149 95185 63184234
Urinary bladder rupture 26.45 10.16 12 209591 142 63279277
Blood cholesterol increased 26.22 10.16 192 209411 93840 63185579
Weight abnormal 26.20 10.16 27 209576 1317 63278102
Paralysis 26.12 10.16 82 209521 9818 63269601
Right ventricular failure 26.11 10.16 12 209591 17176 63262243
Leukopenia 26.04 10.16 149 209454 77141 63202278
Intervertebral disc protrusion 25.85 10.16 150 209453 23559 63255860
Altered state of consciousness 25.82 10.16 157 209446 25073 63254346
Post-traumatic neck syndrome 25.75 10.16 33 209570 2041 63277378
Disorganised speech 25.72 10.16 26 209577 1239 63278180
Head titubation 25.71 10.16 22 209581 846 63278573
Psychomotor retardation 25.71 10.16 46 209557 3824 63275595
Antipsychotic drug level increased 25.66 10.16 43 209560 3392 63276027
Blood sodium decreased 25.52 10.16 152 209451 24100 63255319
Affect lability 25.51 10.16 88 209515 11063 63268356
Apathy 25.22 10.16 75 209528 8719 63270700
Intellectual disability 25.22 10.16 24 209579 1062 63278357
Hereditary angioedema 25.11 10.16 68 209535 7494 63271925
Attention deficit hyperactivity disorder 24.99 10.16 40 209563 3036 63276383
Pollakiuria 24.99 10.16 168 209435 27769 63251650
Tinnitus 24.88 10.16 202 209401 35426 63243993
Pyrexia 24.80 10.16 1285 208318 469193 62810226
Haematochezia 24.71 10.16 92 209511 53452 63225967
Renal disorder 24.70 10.16 190 209413 32784 63246635
Salivary hypersecretion 24.52 10.16 68 209535 7598 63271821
Bronchiectasis 24.49 10.16 112 209491 16030 63263389
Sensory loss 24.48 10.16 82 209521 10156 63269263
Sebaceous gland infection 24.47 10.16 12 209591 171 63279248
Panic reaction 24.45 10.16 47 209556 4127 63275292
Choking 24.40 10.16 80 209523 9799 63269620
Device expulsion 24.38 10.16 49 209554 34873 63244546
Coordination abnormal 24.29 10.16 100 209503 13673 63265746
Hypomania 24.18 10.16 60 209543 6270 63273149
COVID-19 23.95 10.16 248 209355 112855 63166564
Tachyphrenia 23.93 10.16 26 209577 1348 63278071
Concussion 23.87 10.16 76 209527 9168 63270251
Lung disorder 23.78 10.16 115 209488 62146 63217273
Logorrhoea 23.71 10.16 35 209568 2475 63276944
Anorgasmia 23.63 10.16 18 209585 585 63278834
Conversion disorder 23.38 10.16 29 209574 1735 63277684
Neuropathy peripheral 23.35 10.16 251 209352 113416 63166003
Alcohol abuse 23.34 10.16 32 209571 2114 63277305
Sinusitis 23.23 10.16 570 209033 226083 63053336
Upper gastrointestinal haemorrhage 23.18 10.16 17 209586 18835 63260584
Tongue discolouration 23.02 10.16 39 209564 3104 63276315
Renal failure 22.90 10.16 263 209340 117389 63162030
Transplant rejection 22.85 10.16 4 209599 10776 63268643
Drug detoxification 22.76 10.16 14 209589 318 63279101
Somnambulism 22.74 10.16 54 209549 5489 63273930
Arthritis 22.62 10.16 259 209344 115662 63163757
Proteinuria 22.60 10.16 18 209585 19127 63260292
Aspiration 22.57 10.16 83 209520 10768 63268651
Diverticulitis 22.42 10.16 62 209541 39495 63239924
Drug abuser 22.38 10.16 37 209566 2886 63276533
Wound secretion 22.33 10.16 48 209555 4566 63274853
Myoclonic epilepsy 22.32 10.16 24 209579 1230 63278189
Heart rate abnormal 22.28 10.16 50 209553 4897 63274522
Incorrect dose administered 22.28 10.16 299 209304 59669 63219750
Blood iron decreased 22.22 10.16 102 209501 14619 63264800
Abulia 22.20 10.16 16 209587 477 63278942
Blood parathyroid hormone decreased 22.20 10.16 3 209600 9788 63269631
Libido decreased 22.06 10.16 35 209568 2637 63276782
Coma scale abnormal 22.01 10.16 51 209552 5102 63274317
Tic 21.79 10.16 26 209577 1494 63277925
Social anxiety disorder 21.75 10.16 15 209588 416 63279003
Soft tissue injury 21.64 10.16 27 209576 1625 63277794
Feeling cold 21.58 10.16 144 209459 23744 63255675
Stereotypy 21.41 10.16 15 209588 427 63278992
Anaphylactic shock 21.33 10.16 28 209575 23605 63255814
Dysstasia 21.21 10.16 131 209472 21035 63258384
Cytopenia 21.18 10.16 6 209597 11595 63267824
Pulmonary arterial hypertension 21.16 10.16 26 209577 22551 63256868
Dependence 21.14 10.16 30 209573 2047 63277372
Tearfulness 21.12 10.16 44 209559 4095 63275324
Band neutrophil percentage increased 21.04 10.16 12 209591 236 63279183
Respiratory rate decreased 20.95 10.16 40 209563 3495 63275924
Impulsive behaviour 20.94 10.16 26 209577 1557 63277862
Facet joint syndrome 20.86 10.16 7 209596 12131 63267288
Peroneal nerve palsy 20.81 10.16 48 209555 4787 63274632
Adverse event 20.78 10.16 134 209469 67425 63211994
Decreased interest 20.75 10.16 38 209565 3216 63276203
Urticaria 20.72 10.16 404 209199 165398 63114021
Stoma site hypergranulation 20.61 10.16 13 209590 309 63279110
Mental impairment 20.59 10.16 97 209506 14054 63265365
White blood cell count decreased 20.55 10.16 329 209274 138775 63140644
Haemoglobin urine 20.55 10.16 10 209593 140 63279279
Hyperammonaemia 20.42 10.16 50 209553 5182 63274237
Myoclonus 20.40 10.16 105 209498 15763 63263656
Anaphylactic reaction 20.39 10.16 131 209472 65969 63213450
Anion gap increased 20.37 10.16 28 209575 1854 63277565
Bursitis 20.30 10.16 59 209544 36982 63242437
Sputum discoloured 20.21 10.16 107 209496 16240 63263179
Bipolar I disorder 20.17 10.16 28 209575 1871 63277548
Ascites 20.11 10.16 68 209535 40660 63238759
Erythema 19.97 10.16 435 209168 175316 63104103
Psychotic disorder due to a general medical condition 19.85 10.16 12 209591 264 63279155
Dysuria 19.76 10.16 184 209419 33554 63245865
Hypothermia 19.69 10.16 93 209510 13488 63265931
Colitis 19.50 10.16 88 209515 48440 63230979
Screaming 19.44 10.16 37 209566 3225 63276194
Sexual abuse 19.44 10.16 11 209592 213 63279206
Hypertension 19.38 10.16 740 208863 278563 63000856
Hyperreflexia 19.34 10.16 53 209550 5881 63273538
Antidepressant drug level above therapeutic 19.26 10.16 14 209589 423 63278996
Condition aggravated 19.24 10.16 1109 208494 401108 62878311
Stoma site pain 19.16 10.16 20 209583 990 63278429
Acute myeloid leukaemia 19.16 10.16 17 209586 17130 63262289
Inappropriate schedule of product administration 19.15 10.16 464 209139 103501 63175918
Food craving 19.07 10.16 25 209578 1581 63277838
Type 2 diabetes mellitus 18.98 10.16 128 209475 63740 63215679
Fatigue 18.94 10.16 2607 206996 885421 62393998
Weight gain poor 18.94 10.16 19 209584 897 63278522
Hyperammonaemic encephalopathy 18.89 10.16 31 209572 2403 63277016
Hypervolaemia 18.88 10.16 41 209562 28372 63251047
Obstructive airways disorder 18.83 10.16 125 209478 20574 63258845
Wound infection 18.69 10.16 26 209577 21384 63258035
Hypomagnesaemia 18.66 10.16 42 209561 28695 63250724
Anticonvulsant drug level increased 18.62 10.16 24 209579 1493 63277926
Osteoporosis 18.53 10.16 112 209491 57226 63222193
Anticonvulsant drug level below therapeutic 18.53 10.16 16 209587 623 63278796
Blood triglycerides increased 18.46 10.16 86 209517 12402 63267017
Seizure cluster 18.40 10.16 11 209592 237 63279182
Cerebellar atrophy 18.27 10.16 17 209586 731 63278688
Hyperthermia 18.18 10.16 69 209534 9087 63270332
Self-injurious ideation 18.17 10.16 32 209571 2627 63276792
Hyponatraemia 17.78 10.16 261 209342 111639 63167780
Fibrous histiocytoma 17.64 10.16 15 209588 572 63278847
Enuresis 17.63 10.16 31 209572 2542 63276877
Blood prolactin increased 17.60 10.16 37 209566 3466 63275953
Joint range of motion decreased 17.52 10.16 52 209551 32376 63247043
Change in seizure presentation 17.40 10.16 13 209590 410 63279009
Psychiatric symptom 17.37 10.16 47 209556 5176 63274243
Vertigo 17.32 10.16 286 209317 59601 63219818
Basal cell carcinoma 17.30 10.16 42 209561 27949 63251470
Myelocyte percentage increased 17.21 10.16 10 209593 204 63279215
Hypnopompic hallucination 17.20 10.16 7 209596 62 63279357
Trismus 17.20 10.16 39 209564 3846 63275573
Initial insomnia 17.17 10.16 52 209551 6105 63273314
Calculus urinary 17.15 10.16 22 209581 1362 63278057
Hyperphagia 17.09 10.16 25 209578 1754 63277665
Alcohol poisoning 17.05 10.16 26 209577 1893 63277526
Pulmonary hypertension 16.99 10.16 64 209539 37059 63242360
Breast cancer stage II 16.94 10.16 4 209599 8732 63270687
Areflexia 16.92 10.16 34 209569 3084 63276335
Suspected product quality issue 16.74 10.16 10 209593 215 63279204
Cognitive disorder 16.68 10.16 268 209335 55547 63223872
Thrombotic microangiopathy 16.63 10.16 7 209596 10554 63268865
Cyanosis 16.46 10.16 104 209499 16831 63262588
Jaundice 16.46 10.16 46 209557 29205 63250214
Flat affect 16.34 10.16 22 209581 1428 63277991
Oculogyric crisis 16.26 10.16 24 209579 1697 63277722
Cytokine release syndrome 16.23 10.16 14 209589 14300 63265119
Encephalopathy 16.22 10.16 197 209406 38423 63240996
Accidental overdose 16.19 10.16 132 209471 23177 63256242
Blood growth hormone increased 16.19 10.16 13 209590 457 63278962
Compulsive shopping 16.17 10.16 16 209587 743 63278676
Upper respiratory tract infection 16.13 10.16 183 209420 81864 63197555
Abdominal pain upper 16.12 10.16 539 209064 205905 63073514
Full blood count decreased 16.12 10.16 39 209564 25985 63253434
Focal dyscognitive seizures 16.03 10.16 32 209571 2889 63276530
Pneumonitis 15.94 10.16 61 209542 35161 63244258
Neuropsychiatric symptoms 15.92 10.16 16 209587 757 63278662
Visual impairment 15.89 10.16 378 209225 84068 63195351
Cardiac murmur 15.82 10.16 92 209511 14460 63264959
Stoma site erythema 15.73 10.16 20 209583 1227 63278192
Impulse-control disorder 15.63 10.16 16 209587 774 63278645
Mitral valve thickening 15.60 10.16 5 209598 20 63279399
Sensitivity to weather change 15.60 10.16 56 209547 7181 63272238
Epistaxis 15.58 10.16 159 209444 72566 63206853
Increased appetite 15.49 10.16 68 209535 9562 63269857
Blood pressure decreased 15.43 10.16 301 209302 64721 63214698
Haemoglobin decreased 15.41 10.16 364 209239 145121 63134298
Lip dry 15.38 10.16 17 209586 15453 63263966
Torticollis 15.37 10.16 25 209578 1924 63277495
Cerebral atrophy 15.29 10.16 44 209559 5022 63274397
Clumsiness 15.24 10.16 26 209577 2081 63277338
Peripheral pulse decreased 15.17 10.16 6 209597 49 63279370
Feelings of worthlessness 15.11 10.16 11 209592 333 63279086
Anhedonia 15.08 10.16 74 209529 10900 63268519
Myopathy 15.05 10.16 75 209528 11116 63268303
Monocyte count abnormal 15.05 10.16 9 209594 194 63279225
Headache 14.93 10.16 2344 207259 630897 62648522
Shock haemorrhagic 14.89 10.16 7 209596 9888 63269531
Congenital jaw malformation 14.87 10.16 5 209598 24 63279395
Accidental exposure to product by child 14.84 10.16 19 209584 1174 63278245
Disseminated intravascular coagulation 14.83 10.16 25 209578 19026 63260393
Enthesopathy 14.75 10.16 5 209598 8609 63270810
Fluid retention 14.72 10.16 126 209477 59560 63219859
Diplopia 14.70 10.16 131 209472 23597 63255822
Distractibility 14.70 10.16 12 209591 432 63278987
Injection site pruritus 14.65 10.16 88 209515 45028 63234391
Narcotic bowel syndrome 14.61 10.16 8 209595 145 63279274
Abdominal pain 14.58 10.16 806 208797 292650 62986769
Infantile spasms 14.57 10.16 9 209594 206 63279213
Cast application 14.55 10.16 5 209598 26 63279393
Homicidal ideation 14.53 10.16 23 209580 1729 63277690
Feeling drunk 14.51 10.16 38 209565 4104 63275315
Nail disorder 14.43 10.16 13 209590 13002 63266417
Generalised anxiety disorder 14.22 10.16 25 209578 2049 63277370
Metastases to liver 14.19 10.16 36 209567 23603 63255816
Myocardial infarction 14.18 10.16 238 209365 99655 63179764
Hyperbilirubinaemia 14.18 10.16 10 209593 11304 63268115
Drug screen false positive 14.14 10.16 16 209587 868 63278551
Grip strength decreased 14.12 10.16 33 209570 22254 63257165
Electrocardiogram QRS complex shortened 14.12 10.16 12 209591 457 63278962
Liver function test abnormal 14.10 10.16 97 209506 48084 63231335
Intrusive thoughts 14.08 10.16 9 209594 219 63279200
Piloerection 14.01 10.16 11 209592 374 63279045
Pupil fixed 13.99 10.16 23 209580 1786 63277633
Sternal fracture 13.97 10.16 26 209577 2228 63277191
Lip and/or oral cavity cancer 13.94 10.16 16 209587 882 63278537
Autoimmune disorder 13.88 10.16 22 209581 17155 63262264
Pre-existing condition improved 13.87 10.16 59 209544 8185 63271234
Subarachnoid haemorrhage 13.86 10.16 16 209587 14267 63265152
Drop attacks 13.84 10.16 14 209589 668 63278751
Tubulointerstitial nephritis 13.83 10.16 28 209575 19875 63259544
Hallucination, visual 13.79 10.16 110 209493 19188 63260231
Deformity 13.77 10.16 11 209592 11673 63267746
Hypotonia 13.77 10.16 64 209539 9221 63270198
Road traffic accident 13.75 10.16 183 209420 36449 63242970
Confusional state 13.73 10.16 931 208672 235449 63043970
Incision site haemorrhage 13.72 10.16 13 209590 572 63278847
Gaze palsy 13.70 10.16 20 209583 1400 63278019
Breast cancer stage I 13.67 10.16 3 209600 6886 63272533
Pericardial effusion 13.64 10.16 52 209551 30006 63249413
Affective disorder 13.62 10.16 48 209555 6098 63273321
Wrist fracture 13.56 10.16 84 209519 13503 63265916
Hypokalaemia 13.56 10.16 251 209352 103553 63175866
Haematotoxicity 13.55 10.16 7 209596 9369 63270050
Weight decreased 13.51 10.16 1075 208528 275723 63003696
Circulatory collapse 13.49 10.16 33 209570 21905 63257514
Sudden unexplained death in epilepsy 13.45 10.16 10 209593 313 63279106
Temperature intolerance 13.45 10.16 62 209541 8902 63270517
Right ventricular systolic pressure decreased 13.43 10.16 5 209598 34 63279385
Rapid eye movement sleep behaviour disorder 13.37 10.16 10 209593 316 63279103
Poor quality sleep 13.37 10.16 112 209491 19823 63259596
Hyperkeratosis 13.34 10.16 47 209556 5971 63273448
Incision site erythema 13.33 10.16 12 209591 494 63278925
Colitis ulcerative 13.27 10.16 43 209560 26048 63253371
Onychophagia 13.22 10.16 6 209597 71 63279348
Dysphemia 13.14 10.16 28 209575 2647 63276772
Aerophagia 13.12 10.16 4 209599 13 63279406
Nephrogenic diabetes insipidus 13.09 10.16 16 209587 943 63278476
Barotrauma 13.07 10.16 8 209595 180 63279239
Parkinsonian gait 13.07 10.16 12 209591 507 63278912
Liver disorder 12.94 10.16 114 209489 53573 63225846
Bronchial wall thickening 12.88 10.16 20 209583 1479 63277940
Abscess 12.86 10.16 22 209581 16646 63262773
Hypertonia 12.78 10.16 39 209564 4598 63274821
Cushingoid 12.77 10.16 6 209597 8479 63270940
Transfusion 12.77 10.16 19 209584 15198 63264221
Femur fracture 12.75 10.16 83 209520 41673 63237746
Urticaria thermal 12.74 10.16 11 209592 428 63278991
Sensory disturbance 12.70 10.16 83 209520 13589 63265830
Eye pain 12.65 10.16 169 209434 33685 63245734
Hyperacusis 12.63 10.16 24 209579 2089 63277330
Asphyxia 12.62 10.16 47 209556 6134 63273285
Rib fracture 12.61 10.16 122 209481 22475 63256944
Aplastic anaemia 12.61 10.16 8 209595 9561 63269858
Fear of injection 12.54 10.16 4 209599 7160 63272259
Bone density decreased 12.50 10.16 18 209585 14594 63264825
Psychiatric decompensation 12.47 10.16 19 209584 1382 63278037
Haemangioma congenital 12.47 10.16 11 209592 441 63278978
Hypercholesterolaemia 12.42 10.16 33 209570 21301 63258118
Acute generalised exanthematous pustulosis 12.41 10.16 11 209592 11088 63268331
Gastrointestinal procedural complication 12.37 10.16 8 209595 199 63279220
Delirium 12.34 10.16 235 209368 50306 63229113
Pulmonary toxicity 12.32 10.16 8 209595 9447 63269972
Osteoarthritis 12.31 10.16 231 209372 95112 63184307
Hyperkinesia 12.29 10.16 21 209582 1683 63277736
Pathogen resistance 12.27 10.16 3 209600 6395 63273024
Hormone level abnormal 12.21 10.16 26 209577 2457 63276962
Red blood cells urine 12.20 10.16 12 209591 553 63278866
Tonic clonic movements 12.13 10.16 19 209584 1416 63278003
Family stress 12.11 10.16 13 209590 665 63278754
Oculocephalogyric reflex absent 12.08 10.16 3 209600 3 63279416
Cholestasis 12.05 10.16 53 209550 29381 63250038
Colitis microscopic 12.04 10.16 8 209595 9331 63270088
Suspiciousness 12.04 10.16 10 209593 369 63279050
Flight of ideas 12.02 10.16 11 209592 463 63278956
Ulcer 11.95 10.16 45 209558 26062 63253357
Drug level above therapeutic 11.95 10.16 39 209564 4766 63274653
Fever neonatal 11.93 10.16 4 209599 19 63279400
Behaviour disorder 11.88 10.16 30 209573 3169 63276250
Joint destruction 11.86 10.16 3 209600 6249 63273170
Nasal disorder 11.85 10.16 28 209575 2836 63276583
Fractured coccyx 11.83 10.16 16 209587 1043 63278376
Stupor 11.83 10.16 36 209567 4239 63275180
Eating disorder 11.79 10.16 105 209498 18911 63260508
Therapeutic response decreased 11.79 10.16 138 209465 61387 63218032
Product quality issue 11.78 10.16 175 209428 35690 63243729
Sensorimotor disorder 11.78 10.16 11 209592 475 63278944
Adrenal insufficiency 11.78 10.16 26 209577 17889 63261530
Solar lentigo 11.75 10.16 14 209589 803 63278616
Hepatic cirrhosis 11.74 10.16 42 209561 24692 63254727
Illusion 11.70 10.16 16 209587 1054 63278365
Bronchopulmonary aspergillosis 11.68 10.16 7 209596 8628 63270791
Band neutrophil count increased 11.68 10.16 10 209593 385 63279034
Brain death 11.66 10.16 31 209572 3379 63276040
Metastases to lung 11.62 10.16 15 209588 12735 63266684
Bradycardia neonatal 11.59 10.16 15 209588 937 63278482
Lower limb fracture 11.58 10.16 41 209562 24180 63255239
Drug eruption 11.55 10.16 52 209551 28642 63250777
Adjustment disorder with depressed mood 11.54 10.16 10 209593 10194 63269225
Antinuclear antibody positive 11.52 10.16 6 209597 7993 63271426
Oliguria 11.46 10.16 8 209595 9093 63270326
Toxicologic test abnormal 11.45 10.16 13 209590 708 63278711
Blood bilirubin increased 11.35 10.16 179 209424 36961 63242458
Heat stroke 11.33 10.16 14 209589 834 63278585
Acute myocardial infarction 11.32 10.16 61 209542 32063 63247356
Accidental death 11.27 10.16 22 209581 1954 63277465
Sarcoidosis 11.24 10.16 50 209553 7072 63272347
Decreased activity 11.23 10.16 46 209557 6274 63273145
Orthostatic tremor 11.22 10.16 3 209600 5 63279414
Juvenile myoclonic epilepsy 11.16 10.16 4 209599 24 63279395
Skin necrosis 11.15 10.16 18 209585 13932 63265487
Cataplexy 11.13 10.16 17 209586 1239 63278180
Hypersexuality 11.11 10.16 11 209592 511 63278908
Sinus disorder 11.09 10.16 127 209476 24426 63254993
Social avoidant behaviour 11.08 10.16 28 209575 2960 63276459
Retinal detachment 11.06 10.16 3 209600 5966 63273453
Sleep disorder 11.06 10.16 350 209253 81216 63198203
Cholecystitis chronic 10.94 10.16 65 209538 10296 63269123
Neoplasm malignant 10.92 10.16 56 209547 29805 63249614
Temporomandibular joint syndrome 10.91 10.16 34 209569 4055 63275364
Chronic papillomatous dermatitis 10.88 10.16 5 209598 61 63279358
Automatism 10.88 10.16 5 209598 61 63279358
Diabetes mellitus 10.86 10.16 251 209352 55559 63223860
Administration site erythema 10.83 10.16 13 209590 752 63278667
Cardiac infection 10.80 10.16 11 209592 529 63278890
Polydipsia 10.80 10.16 31 209572 3533 63275886
Panniculitis 10.79 10.16 13 209590 11372 63268047
Parasomnia 10.73 10.16 11 209592 533 63278886
Device difficult to use 10.71 10.16 16 209587 12780 63266639
Pancreatolithiasis 10.69 10.16 8 209595 253 63279166
Urine oxalate increased 10.66 10.16 8 209595 254 63279165
Fibromyalgia 10.62 10.16 344 209259 80076 63199343
Sciatica 10.60 10.16 68 209535 34256 63245163
Hypoacusis 10.50 10.16 124 209479 24027 63255392
Device use error 10.48 10.16 3 209600 5758 63273661
Body height increased 10.47 10.16 5 209598 67 63279352
Rash maculo-papular 10.47 10.16 62 209541 31834 63247585
Therapeutic product effect prolonged 10.43 10.16 9 209594 350 63279069
Klebsiella test positive 10.43 10.16 16 209587 1171 63278248
Metastases to central nervous system 10.39 10.16 17 209586 13088 63266331
Electrocardiogram QRS complex prolonged 10.38 10.16 43 209560 5895 63273524
Breast cancer female 10.37 10.16 18 209585 13541 63265878
Coagulopathy 10.35 10.16 34 209569 20510 63258909
Aspergillus infection 10.34 10.16 7 209596 8086 63271333
Treatment noncompliance 10.33 10.16 177 209426 37148 63242271
Abdominal distension 10.30 10.16 366 209237 86249 63193170
Localised infection 10.30 10.16 58 209545 30152 63249267
Perfume sensitivity 10.30 10.16 13 209590 792 63278627
Blood potassium increased 10.29 10.16 99 209504 18210 63261209
Illness 10.29 10.16 223 209380 48836 63230583
Ischaemic stroke 10.28 10.16 28 209575 17929 63261490
Large intestine operation 10.28 10.16 3 209600 8 63279411
Immunoglobulins increased 10.28 10.16 10 209593 455 63278964
Apnoea 10.26 10.16 53 209550 7969 63271450
Polyarthritis 10.25 10.16 11 209592 10135 63269284
Multiple organ dysfunction syndrome 10.22 10.16 129 209474 56623 63222796
Congenital knee deformity 10.21 10.16 5 209598 71 63279348
Neurological symptom 10.21 10.16 42 209561 5741 63273678
Stoma site infection 10.21 10.16 13 209590 799 63278620
Myelocyte count increased 10.20 10.16 9 209594 361 63279058
Conjunctivitis allergic 10.17 10.16 14 209589 928 63278491
Rectal haemorrhage 10.17 10.16 108 209495 48922 63230497

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 1467.64 10.72 1691 109963 97405 34747872
Depression 977.42 10.72 1368 110286 95730 34749547
Completed suicide 875.33 10.72 1306 110348 96862 34748415
Toxicity to various agents 696.02 10.72 1789 109865 198573 34646704
Drug interaction 440.04 10.72 1650 110004 224296 34620981
Somnolence 434.06 10.72 1039 110615 110077 34735200
Coma 365.83 10.72 579 111075 45099 34800178
Sopor 363.25 10.72 305 111349 11831 34833446
Overdose 361.40 10.72 857 110797 90202 34755075
Suicidal ideation 311.10 10.72 503 111151 39885 34805392
Intentional overdose 297.78 10.72 515 111139 43159 34802118
Miosis 281.98 10.72 238 111416 9297 34835980
Neuroleptic malignant syndrome 272.72 10.72 311 111343 17623 34827654
Aggression 270.26 10.72 463 111191 38501 34806776
Psychiatric decompensation 261.48 10.72 145 111509 2792 34842485
Anxiety 259.60 10.72 802 110852 98626 34746651
Psychotic disorder 259.44 10.72 354 111300 24098 34821179
Drug dependence 259.07 10.72 352 111302 23865 34821412
Suicide attempt 257.21 10.72 454 111200 38662 34806615
Agitation 247.04 10.72 558 111096 56841 34788436
Seizure 237.74 10.72 806 110848 104051 34741226
Poisoning 235.02 10.72 240 111414 11986 34833291
Respiratory arrest 234.88 10.72 363 111291 27680 34817597
Substance abuse 206.18 10.72 181 111473 7460 34837817
Cardio-respiratory arrest 196.49 10.72 499 111155 54774 34790503
Febrile neutropenia 191.60 10.72 99 111555 136750 34708527
Altered state of consciousness 189.83 10.72 295 111359 22598 34822679
Intentional product misuse 188.01 10.72 436 111218 45175 34800102
Paranoia 181.30 10.72 208 111446 11860 34833417
Drug withdrawal syndrome 176.33 10.72 264 111390 19570 34825707
Sedation 176.00 10.72 272 111382 20734 34824543
Anaemia 174.10 10.72 299 111355 233036 34612241
Abnormal behaviour 172.15 10.72 296 111358 24673 34820604
Intentional self-injury 168.69 10.72 214 111440 13557 34831720
Depression suicidal 168.22 10.72 103 111551 2402 34842875
Tearfulness 164.78 10.72 104 111550 2563 34842714
Depressed level of consciousness 164.07 10.72 398 111256 42443 34802834
Psychomotor skills impaired 157.41 10.72 117 111537 3789 34841488
Status epilepticus 156.06 10.72 197 111457 12417 34832860
Depressive symptom 148.51 10.72 100 111554 2759 34842518
Acute kidney injury 147.81 10.72 491 111163 304497 34540780
Dyspnoea 143.53 10.72 668 110986 376114 34469163
Dyskinesia 130.63 10.72 247 111407 22166 34823111
Loss of personal independence in daily activities 127.83 10.72 309 111345 32870 34812407
Panic attack 119.37 10.72 149 111505 9283 34835994
Diarrhoea 119.25 10.72 744 110910 389168 34456109
Hallucination 117.53 10.72 397 111257 51101 34794176
Interstitial lung disease 114.82 10.72 33 111621 65249 34780028
Malignant neoplasm progression 114.08 10.72 70 111584 87976 34757301
Pancytopenia 112.13 10.72 84 111570 95073 34750204
Speech disorder 111.84 10.72 251 111403 25435 34819842
Insomnia 108.66 10.72 634 111020 103273 34742004
Thrombocytopenia 105.93 10.72 212 111442 156035 34689242
Mydriasis 105.78 10.72 123 111531 7114 34838163
Bradykinesia 104.58 10.72 92 111562 3801 34841476
Salivary hypersecretion 102.19 10.72 132 111522 8512 34836765
Disease progression 100.77 10.72 118 111536 107959 34737318
Sepsis 100.55 10.72 241 111413 166320 34678957
On and off phenomenon 96.62 10.72 73 111581 2424 34842853
Ataxia 96.48 10.72 165 111489 13688 34831589
Parkinsonism 94.22 10.72 123 111531 8015 34837262
Cardiac arrest 93.66 10.72 576 111078 95583 34749694
Pneumonia aspiration 91.19 10.72 318 111336 41585 34803692
Dystonia 88.83 10.72 139 111515 10706 34834571
Delusion 88.66 10.72 151 111503 12484 34832793
Pneumonia 87.96 10.72 739 110915 361888 34483389
Muscle rigidity 86.41 10.72 135 111519 10383 34834894
Psychomotor retardation 85.76 10.72 80 111574 3570 34841707
Atrial fibrillation 85.57 10.72 163 111491 122230 34723047
Bradyphrenia 84.68 10.72 90 111564 4708 34840569
Bradypnoea 84.42 10.72 71 111583 2758 34842519
Restlessness 83.25 10.72 223 111431 25259 34820018
Platelet count decreased 82.33 10.72 161 111493 119556 34725721
Psychomotor hyperactivity 81.15 10.72 125 111529 9497 34835780
Hallucination, auditory 80.44 10.72 140 111514 11777 34833500
Rash 80.41 10.72 402 111252 222350 34622927
Pyrexia 80.11 10.72 680 110974 332333 34512944
Epilepsy 77.29 10.72 195 111459 21300 34823977
Serotonin syndrome 77.14 10.72 186 111468 19747 34825530
Thinking abnormal 76.15 10.72 96 111558 6041 34839236
Drug withdrawal convulsions 75.49 10.72 47 111607 1130 34844147
Cardiac failure 75.40 10.72 109 111545 91139 34754138
Prescribed overdose 74.38 10.72 127 111527 10520 34834757
Victim of crime 73.68 10.72 32 111622 351 34844926
Renal failure 73.25 10.72 196 111458 130361 34714916
Granulocytopenia 72.54 10.72 97 111557 6470 34838807
Device dislocation 71.65 10.72 94 111560 6155 34839122
General physical health deterioration 71.63 10.72 193 111461 128076 34717201
Tremor 71.35 10.72 480 111174 82107 34763170
Mental impairment 70.64 10.72 122 111532 10200 34835077
Neutropenia 70.60 10.72 260 111394 156518 34688759
Irritability 69.77 10.72 205 111449 24485 34820792
Renal impairment 69.49 10.72 122 111532 94391 34750886
Generalised tonic-clonic seizure 67.85 10.72 184 111470 20990 34824287
Myocardial infarction 66.25 10.72 184 111470 120901 34724376
Drug use disorder 65.93 10.72 74 111580 4117 34841160
Cognitive disorder 65.25 10.72 221 111433 28472 34816805
Hyperkalaemia 64.39 10.72 76 111578 69313 34775964
Stoma site discharge 64.37 10.72 43 111611 1170 34844107
Gastrointestinal haemorrhage 64.33 10.72 115 111539 88362 34756915
Catatonia 62.97 10.72 79 111575 4946 34840331
Pleural effusion 62.02 10.72 103 111551 81443 34763834
Akathisia 61.02 10.72 100 111554 8009 34837268
Device interaction 60.93 10.72 32 111622 550 34844727
Posture abnormal 60.32 10.72 53 111601 2186 34843091
Anger 59.60 10.72 123 111531 11761 34833516
Disturbance in attention 59.14 10.72 200 111454 25745 34819532
Myoclonic epilepsy 58.97 10.72 40 111614 1117 34844160
Ascites 58.95 10.72 38 111616 46533 34798744
COVID-19 58.93 10.72 98 111556 77452 34767825
Memory impairment 58.68 10.72 284 111370 43034 34802243
Confusional state 58.20 10.72 710 110944 143450 34701827
Joint swelling 57.29 10.72 64 111590 59826 34785451
Multiple-drug resistance 55.76 10.72 76 111578 5163 34840114
Respiratory depression 54.91 10.72 144 111510 16101 34829176
Cardiac failure congestive 54.65 10.72 115 111539 83155 34762122
Unresponsive to stimuli 53.83 10.72 202 111452 27367 34817910
Dysarthria 53.74 10.72 237 111417 34545 34810732
Gait disturbance 52.32 10.72 457 111197 84683 34760594
Tardive dyskinesia 51.34 10.72 77 111577 5713 34839564
Middle insomnia 51.34 10.72 84 111570 6718 34838559
Haemoglobin decreased 51.30 10.72 205 111449 120567 34724710
Drooling 50.29 10.72 58 111596 3324 34841953
Mucosal inflammation 49.58 10.72 31 111623 38591 34806686
Mental disorder 49.56 10.72 133 111521 15076 34830201
Mania 49.54 10.72 100 111554 9411 34835866
Withdrawal syndrome 49.02 10.72 117 111537 12338 34832939
Fall 49.02 10.72 915 110739 201970 34643307
Drug ineffective 48.74 10.72 1849 109805 454902 34390375
Dyspnoea exertional 48.68 10.72 40 111614 43239 34802038
Hallucination, visual 48.63 10.72 146 111508 17645 34827632
Nervousness 48.10 10.72 117 111537 12489 34832788
Disorientation 47.43 10.72 221 111433 32967 34812310
Stoma site erythema 47.11 10.72 31 111623 822 34844455
Stomatitis 46.94 10.72 40 111614 42474 34802803
Nausea 46.53 10.72 785 110869 339123 34506154
Myoclonus 46.22 10.72 127 111527 14598 34830679
Infusion related reaction 46.19 10.72 61 111593 52996 34792281
Housebound 46.16 10.72 20 111634 218 34845059
Behaviour disorder 45.99 10.72 67 111587 4843 34840434
Hyperprolactinaemia 45.46 10.72 39 111615 1557 34843720
Freezing phenomenon 44.70 10.72 38 111616 1498 34843779
Drug abuser 44.59 10.72 59 111595 3895 34841382
Angioedema 43.98 10.72 33 111621 37341 34807936
Loss of consciousness 43.87 10.72 430 111224 82237 34763040
Infection 43.40 10.72 147 111507 90768 34754509
Urticaria 42.75 10.72 84 111570 62293 34782984
Acute myocardial infarction 42.57 10.72 66 111588 53653 34791624
Blood creatinine increased 42.39 10.72 158 111496 94818 34750459
Crying 42.37 10.72 71 111583 5791 34839486
Multiple organ dysfunction syndrome 42.11 10.72 116 111538 76450 34768827
Schizophrenia 41.48 10.72 88 111566 8578 34836699
Cerebrovascular accident 41.26 10.72 136 111518 84675 34760602
Colitis 41.09 10.72 36 111618 37714 34807563
Reduced facial expression 40.24 10.72 31 111623 1060 34844217
Pruritus 40.08 10.72 277 111377 141704 34703573
Visceral congestion 40.01 10.72 25 111629 605 34844672
Abnormal dreams 39.86 10.72 80 111574 7498 34837779
Screaming 39.72 10.72 35 111619 1449 34843828
Cerebral haemorrhage 39.65 10.72 32 111622 34905 34810372
Cytomegalovirus infection 39.44 10.72 17 111637 26118 34819159
Myelosuppression 39.33 10.72 7 111647 19258 34826019
Lactic acidosis 39.27 10.72 32 111622 34740 34810537
Decreased appetite 38.86 10.72 342 111312 166050 34679227
Pneumocystis jirovecii pneumonia 38.46 10.72 8 111646 19702 34825575
Bone marrow failure 38.22 10.72 23 111631 29230 34816047
Anticonvulsant drug level above therapeutic 38.19 10.72 25 111629 657 34844620
Erythema 38.13 10.72 150 111504 88630 34756647
Accidental death 38.01 10.72 43 111611 2413 34842864
Dystonic tremor 37.94 10.72 17 111637 202 34845075
Blood creatine phosphokinase increased 37.68 10.72 259 111395 44598 34800679
Prostate cancer 37.23 10.72 43 111611 39606 34805671
Priapism 36.78 10.72 61 111593 4933 34840344
Partial seizures 36.22 10.72 59 111595 4701 34840576
Cytokine release syndrome 35.95 10.72 14 111640 22863 34822414
Melaena 35.85 10.72 36 111618 35344 34809933
Myelopathy 35.76 10.72 42 111612 2455 34842822
Contraindicated product administered 35.70 10.72 12 111642 21469 34823808
Agoraphobia 35.66 10.72 17 111637 235 34845042
Post-anoxic myoclonus 35.60 10.72 9 111645 11 34845266
Accidental overdose 35.59 10.72 143 111511 19997 34825280
Affect lability 35.58 10.72 51 111603 3632 34841645
Toxicologic test abnormal 35.15 10.72 22 111632 534 34844743
Dysphoria 35.11 10.72 40 111614 2262 34843015
Anaphylactic reaction 34.92 10.72 31 111623 32270 34813007
Drug diversion 34.68 10.72 26 111628 853 34844424
Oedema peripheral 34.68 10.72 232 111422 119580 34725697
Drug intolerance 34.46 10.72 88 111566 59482 34785795
Hyperammonaemia 34.43 10.72 68 111586 6299 34838978
Arthralgia 34.41 10.72 362 111292 169679 34675598
Septic shock 34.38 10.72 116 111538 71718 34773559
Hypertonia 34.18 10.72 54 111600 4192 34841085
Coronary artery disease 34.01 10.72 64 111590 48241 34797036
Compartment syndrome 33.98 10.72 45 111609 2973 34842304
Proteinuria 33.55 10.72 9 111645 18633 34826644
Encephalitis toxic 33.51 10.72 17 111637 271 34845006
Hypothermia 33.04 10.72 92 111562 10656 34834621
Bronchopulmonary aspergillosis 32.99 10.72 4 111650 14655 34830622
Haematochezia 32.46 10.72 62 111592 46472 34798805
Neuropathy peripheral 32.46 10.72 146 111508 83117 34762160
Psychogenic seizure 32.29 10.72 18 111636 350 34844927
Feeling of despair 32.25 10.72 26 111628 951 34844326
Plasma cell myeloma 32.03 10.72 53 111601 41984 34803293
Sleep apnoea syndrome 31.78 10.72 139 111515 20182 34825095
Product substitution issue 31.61 10.72 87 111567 10008 34835269
Drug screen positive 31.54 10.72 50 111604 3893 34841384
Withdrawal arrhythmia 31.53 10.72 10 111644 40 34845237
Drug hypersensitivity 31.51 10.72 141 111513 80388 34764889
Illness anxiety disorder 31.50 10.72 14 111640 163 34845114
Bipolar disorder 31.41 10.72 48 111606 3621 34841656
Drug level above therapeutic 31.32 10.72 52 111602 4209 34841068
Haematuria 31.30 10.72 71 111583 49995 34795282
Thrombosis 31.19 10.72 72 111582 50386 34794891
Meconium aspiration syndrome 31.15 10.72 10 111644 42 34845235
Electroencephalogram abnormal 31.12 10.72 39 111615 2439 34842838
Cough 31.04 10.72 318 111336 149822 34695455
Depressed mood 30.88 10.72 133 111521 19184 34826093
Torticollis 30.45 10.72 27 111627 1127 34844150
Neutropenic sepsis 30.39 10.72 4 111650 13763 34831514
Accidental poisoning 30.35 10.72 23 111631 767 34844510
Brain scan abnormal 30.28 10.72 24 111630 856 34844421
Feeling abnormal 30.22 10.72 322 111332 62913 34782364
Delirium 30.12 10.72 242 111412 43749 34801528
Excessive eye blinking 30.11 10.72 20 111634 539 34844738
Blood creatine phosphokinase 30.01 10.72 12 111642 105 34845172
Postmortem blood drug level abnormal 29.95 10.72 16 111638 285 34844992
Myelodysplastic syndrome 29.78 10.72 12 111642 19196 34826081
Postmortem blood drug level increased 29.57 10.72 15 111639 239 34845038
Movement disorder 29.31 10.72 96 111558 12152 34833125
COVID-19 pneumonia 29.05 10.72 9 111645 16958 34828319
Cerebral infarction 28.90 10.72 27 111627 27428 34817849
Disinhibition 28.74 10.72 43 111611 3183 34842094
Poor quality sleep 28.74 10.72 74 111580 8182 34837095
Panic disorder 28.53 10.72 27 111627 1227 34844050
Vessel puncture site erythema 28.50 10.72 6 111648 0 34845277
Cerebral artery thrombosis 28.41 10.72 22 111632 758 34844519
Drug screen negative 28.12 10.72 13 111641 167 34845110
Basal cell carcinoma 27.79 10.72 14 111640 19644 34825633
Developmental delay 27.65 10.72 39 111615 2736 34842541
Generalised anxiety disorder 27.63 10.72 22 111632 790 34844487
Balance disorder 27.49 10.72 223 111431 40431 34804846
Dehydration 27.38 10.72 274 111380 129695 34715582
Electrocardiogram QRS complex prolonged 27.35 10.72 53 111601 4841 34840436
Obsessive-compulsive disorder 27.21 10.72 57 111597 5507 34839770
Red cell distribution width decreased 27.06 10.72 13 111641 183 34845094
Failure to suspend medication 26.86 10.72 17 111637 421 34844856
Tubulointerstitial nephritis 26.81 10.72 17 111637 21007 34824270
Bacteraemia 26.47 10.72 15 111639 19702 34825575
Choreoathetosis 26.31 10.72 24 111630 1040 34844237
Hypomagnesaemia 26.08 10.72 19 111635 21832 34823445
Coordination abnormal 26.08 10.72 68 111586 7576 34837701
Aspergillus infection 26.02 10.72 4 111650 12250 34833027
Vomiting 25.88 10.72 598 111056 247023 34598254
Acute myeloid leukaemia 25.84 10.72 13 111641 18257 34827020
Brain injury 25.59 10.72 59 111595 6083 34839194
Peripheral swelling 25.38 10.72 142 111512 76399 34768878
Tension 25.37 10.72 33 111621 2142 34843135
Epistaxis 25.27 10.72 98 111556 58153 34787124
Haemorrhage 25.23 10.72 82 111572 51288 34793989
Cytopenia 25.17 10.72 5 111649 12718 34832559
Blood bilirubin increased 25.02 10.72 53 111601 38243 34807034
Medication error 24.75 10.72 153 111501 25412 34819865
Purpura fulminans 24.57 10.72 10 111644 92 34845185
Stoma site extravasation 24.47 10.72 10 111644 93 34845184
International normalised ratio increased 24.33 10.72 74 111580 47253 34798024
Brain oedema 24.31 10.72 98 111556 13723 34831554
Gastrointestinal hypermotility 24.24 10.72 11 111643 135 34845142
Rheumatoid arthritis 24.08 10.72 54 111600 38184 34807093
Extrapyramidal disorder 24.01 10.72 93 111561 12787 34832490
Hepatotoxicity 23.98 10.72 20 111634 21465 34823812
Gambling disorder 23.90 10.72 28 111626 1632 34843645
Talipes 23.73 10.72 30 111624 1893 34843384
Palmar-plantar erythrodysaesthesia syndrome 23.68 10.72 12 111642 16783 34828494
Feeling guilty 23.54 10.72 14 111640 309 34844968
Asthenia 23.51 10.72 600 111054 244651 34600626
Arthritis 23.44 10.72 40 111614 31306 34813971
Off label use 23.36 10.72 1099 110555 418425 34426852
Neoplasm progression 23.27 10.72 24 111630 23276 34822001
Restless legs syndrome 23.25 10.72 69 111585 8285 34836992
Muscle contracture 23.14 10.72 24 111630 1220 34844057
Atonic seizures 23.04 10.72 13 111641 259 34845018
Haematemesis 22.97 10.72 33 111621 27678 34817599
Tumour lysis syndrome 22.87 10.72 13 111641 17046 34828231
Tachyphrenia 22.74 10.72 24 111630 1245 34844032
Treatment failure 22.62 10.72 75 111579 46622 34798655
Stereotypy 22.57 10.72 19 111635 739 34844538
Pulmonary embolism 22.48 10.72 181 111473 89565 34755712
Blunted affect 22.14 10.72 14 111640 346 34844931
Liver disorder 22.11 10.72 45 111609 32952 34812325
Hepatic cirrhosis 22.08 10.72 14 111640 17300 34827977
Pulmonary fibrosis 21.95 10.72 16 111638 18380 34826897
Somnambulism 21.93 10.72 37 111617 3035 34842242
Testicular infarction 21.79 10.72 8 111646 54 34845223
Angina pectoris 21.68 10.72 42 111612 31321 34813956
Gaze palsy 21.59 10.72 27 111627 1685 34843592
Psychotic behaviour 21.58 10.72 18 111636 691 34844586
Amnesia 21.49 10.72 152 111502 26411 34818866
Cogwheel rigidity 21.48 10.72 24 111630 1328 34843949
Chills 21.45 10.72 161 111493 80882 34764395
Shock haemorrhagic 21.36 10.72 5 111649 11349 34833928
Intensive care unit acquired weakness 21.27 10.72 21 111633 1006 34844271
Physical assault 21.13 10.72 22 111632 1123 34844154
Hypotonia 21.04 10.72 64 111590 7789 34837488
Congenital melanocytic naevus 21.03 10.72 6 111648 15 34845262
Cerebellar atrophy 21.00 10.72 16 111638 538 34844739
Nephropathy toxic 20.98 10.72 7 111647 12581 34832696
Ehlers-Danlos syndrome 20.82 10.72 7 111647 35 34845242
Sinus tachycardia 20.82 10.72 110 111544 17250 34828027
Psychiatric symptom 20.81 10.72 39 111615 3474 34841803
Sedation complication 20.79 10.72 27 111627 1750 34843527
Exposure via ingestion 20.77 10.72 30 111624 2151 34843126
Personality disorder 20.77 10.72 22 111632 1146 34844131
Parasomnia 20.67 10.72 14 111640 390 34844887
Hypertension 20.63 10.72 309 111345 136134 34709143
Upper gastrointestinal haemorrhage 20.55 10.72 31 111623 25487 34819790
Multiple sclerosis 20.54 10.72 57 111597 6588 34838689
Nystagmus 20.43 10.72 46 111608 4669 34840608
Obsessive-compulsive personality disorder 20.37 10.72 10 111644 148 34845129
Laboratory test abnormal 20.37 10.72 21 111633 20370 34824907
Wrong patient received product 20.33 10.72 33 111621 2621 34842656
Haemophagocytic lymphohistiocytosis 20.28 10.72 8 111646 12965 34832312
Tooth injury 20.20 10.72 22 111632 1183 34844094
Stoma site inflammation 20.17 10.72 15 111639 486 34844791
Change in seizure presentation 20.02 10.72 10 111644 154 34845123
Rhabdomyolysis 19.86 10.72 317 111337 67846 34777431
Adrenal insufficiency 19.86 10.72 10 111644 14037 34831240
Phaeochromocytoma malignant 19.81 10.72 8 111646 72 34845205
Erectile dysfunction 19.66 10.72 123 111531 20514 34824763
Drug tolerance 19.63 10.72 34 111620 2848 34842429
Rash pruritic 19.58 10.72 35 111619 26906 34818371
Parkinsonian gait 19.52 10.72 15 111639 511 34844766
Stoma site infection 19.51 10.72 18 111636 792 34844485
Blood prolactin increased 19.44 10.72 26 111628 1734 34843543
Chronic kidney disease 19.40 10.72 67 111587 41143 34804134
Thrombotic microangiopathy 19.38 10.72 5 111649 10625 34834652
Weight increased 19.19 10.72 410 111244 92623 34752654
Suspected suicide 19.11 10.72 45 111609 4703 34840574
Hypomania 18.99 10.72 30 111624 2329 34842948
Injection site exfoliation 18.92 10.72 6 111648 24 34845253
Myalgia 18.68 10.72 175 111479 83935 34761342
Clonic convulsion 18.67 10.72 16 111638 638 34844639
Inflammation 18.61 10.72 39 111615 28256 34817021
Antidepressant drug level increased 18.59 10.72 9 111645 129 34845148
Language disorder 18.59 10.72 29 111625 2227 34843050
Autonomic nervous system imbalance 18.57 10.72 31 111623 2520 34842757
Cluster headache 18.55 10.72 15 111639 551 34844726
Bradycardia 18.45 10.72 341 111313 75077 34770200
Persecutory delusion 18.32 10.72 31 111623 2549 34842728
Squamous cell carcinoma of skin 18.22 10.72 6 111648 10875 34834402
Embedded device 18.21 10.72 12 111642 319 34844958
Substance use disorder 18.16 10.72 17 111637 762 34844515
Impulsive behaviour 18.10 10.72 28 111626 2134 34843143
Postictal paralysis 18.10 10.72 11 111643 253 34845024
Lethargy 18.08 10.72 206 111448 40916 34804361
Major depression 18.05 10.72 43 111611 4529 34840748
Hypersomnia 18.00 10.72 83 111571 12324 34832953
Physical abuse 17.97 10.72 5 111649 11 34845266
Postoperative respiratory failure 17.93 10.72 9 111645 140 34845137
Swelling 17.91 10.72 72 111582 42294 34802983
Road traffic accident 17.89 10.72 106 111548 17344 34827933
Hyperchloraemia 17.84 10.72 14 111640 492 34844785
HIV peripheral neuropathy 17.84 10.72 6 111648 30 34845247
Nightmare 17.81 10.72 92 111562 14299 34830978
Hyperthermia 17.81 10.72 74 111580 10503 34834774
Arthropathy 17.77 10.72 37 111617 26870 34818407
Infantile spasms 17.69 10.72 10 111644 200 34845077
Abdominal pain 17.67 10.72 393 111261 163225 34682052
Electrocardiogram QT shortened 17.65 10.72 9 111645 145 34845132
Dysmetria 17.52 10.72 15 111639 597 34844680
Injection site dryness 17.37 10.72 6 111648 33 34845244
Oedema 17.34 10.72 81 111573 45660 34799617
Rapid eye movement sleep behaviour disorder 17.33 10.72 9 111645 151 34845126
Osteonecrosis of jaw 17.23 10.72 19 111635 17870 34827407
Hypokalaemia 17.19 10.72 112 111542 58102 34787175
Areflexia 17.15 10.72 33 111621 2998 34842279
Opsoclonus myoclonus 17.05 10.72 7 111647 66 34845211
Cholestasis 17.01 10.72 38 111616 26910 34818367
Stupor 17.01 10.72 32 111622 2859 34842418
Hyperarousal 16.94 10.72 6 111648 36 34845241
Developmental regression 16.94 10.72 6 111648 36 34845241
Dopamine dysregulation syndrome 16.91 10.72 13 111641 443 34844834
Heat stroke 16.85 10.72 18 111636 947 34844330
Treatment noncompliance 16.81 10.72 150 111504 27950 34817327
Personality change 16.80 10.72 45 111609 5094 34840183
Petit mal epilepsy 16.80 10.72 33 111621 3045 34842232
Atrial flutter 16.77 10.72 15 111639 15559 34829718
Bruxism 16.72 10.72 24 111630 1711 34843566
Death 16.70 10.72 1072 110582 396977 34448300
Blood uric acid increased 16.66 10.72 5 111649 9619 34835658
Post-traumatic stress disorder 16.65 10.72 25 111629 1856 34843421
Poverty of speech 16.61 10.72 10 111644 226 34845051
Pneumothorax 16.56 10.72 22 111632 19070 34826207
Lymphadenopathy 16.49 10.72 42 111612 28421 34816856
Renal hypertension 16.47 10.72 9 111645 168 34845109
Myositis 16.46 10.72 9 111645 12061 34833216
Borderline personality disorder 16.43 10.72 12 111642 378 34844899
Haemorrhage intracranial 16.41 10.72 16 111638 15930 34829347
Syncope 16.38 10.72 200 111454 91251 34754026
Hyperkinesia 16.38 10.72 24 111630 1744 34843533
Suicidal behaviour 16.36 10.72 22 111632 1475 34843802
Pulmonary hypertension 16.29 10.72 26 111628 20898 34824379
Apathy 16.29 10.72 54 111600 6878 34838399
Homicidal ideation 16.17 10.72 30 111624 2652 34842625
Venoocclusive liver disease 16.03 10.72 3 111651 7963 34837314
Dry skin 16.02 10.72 49 111605 31238 34814039
Encephalopathy 16.01 10.72 178 111476 35141 34810136
Bladder cancer 15.99 10.72 17 111637 16261 34829016
Spinal shock 15.92 10.72 6 111648 44 34845233
Depersonalisation/derealisation disorder 15.88 10.72 14 111640 580 34844697
Weight abnormal 15.84 10.72 15 111639 682 34844595
Pseudomonas infection 15.80 10.72 10 111644 12372 34832905
Cardiac failure chronic 15.79 10.72 3 111651 7876 34837401
Graft versus host disease 15.75 10.72 7 111647 10562 34834715
Stoma site hypergranulation 15.75 10.72 9 111645 184 34845093
Inappropriate affect 15.73 10.72 15 111639 688 34844589
Tuberculosis 15.70 10.72 4 111650 8573 34836704
Clonus 15.64 10.72 30 111624 2720 34842557
Sexual dysfunction 15.62 10.72 50 111604 6253 34839024
Hyperglycaemia 15.51 10.72 69 111585 39411 34805866
Staphylococcal sepsis 15.51 10.72 6 111648 9838 34835439
Postmortem blood drug level 15.41 10.72 9 111645 192 34845085
Neurotoxicity 15.37 10.72 21 111633 17989 34827288
Labelled drug-drug interaction medication error 15.36 10.72 15 111639 14924 34830353
Staphylococcal bacteraemia 15.36 10.72 4 111650 8448 34836829
Fluid retention 15.33 10.72 40 111614 26847 34818430
Libido decreased 15.23 10.72 41 111613 4655 34840622
Blood bicarbonate decreased 15.22 10.72 28 111626 2459 34842818
Intelligence test abnormal 15.21 10.72 5 111649 23 34845254
Aplastic anaemia 15.18 10.72 6 111648 9710 34835567
Hostility 15.13 10.72 16 111638 832 34844445
Feeling jittery 15.10 10.72 37 111617 3966 34841311
Panic reaction 15.10 10.72 21 111633 1454 34843823
Libido increased 15.08 10.72 16 111638 835 34844442
Lymphopenia 15.02 10.72 18 111636 16317 34828960
Self esteem decreased 15.00 10.72 13 111641 526 34844751
Galactorrhoea 14.90 10.72 12 111642 438 34844839
Antipsychotic drug level increased 14.88 10.72 36 111618 3829 34841448
Asterixis 14.84 10.72 19 111635 1214 34844063
Herpes zoster 14.83 10.72 58 111596 34341 34810936
Obsessive thoughts 14.83 10.72 15 111639 740 34844537
Hypocalcaemia 14.73 10.72 35 111619 24254 34821023
Defect conduction intraventricular 14.67 10.72 11 111643 361 34844916
Sleep-related eating disorder 14.63 10.72 10 111644 283 34844994
Synovitis 14.61 10.72 14 111640 14052 34831225
Oropharyngeal pain 14.56 10.72 61 111593 35424 34809853
Conduction disorder 14.51 10.72 25 111629 2085 34843192
Ejaculation disorder 14.49 10.72 17 111637 992 34844285
Bacterial infection 14.46 10.72 20 111634 17043 34828234
Substance dependence 14.38 10.72 11 111643 372 34844905
Neurosis 14.38 10.72 8 111646 155 34845122
Eye movement disorder 14.37 10.72 37 111617 4090 34841187
Anhidrosis 14.36 10.72 7 111647 102 34845175
Patient uncooperative 14.33 10.72 12 111642 463 34844814
Anal spasm 14.25 10.72 3 111651 0 34845277
Eustachian tube disorder 14.25 10.72 3 111651 0 34845277
Clostridium difficile infection 14.23 10.72 24 111630 18874 34826403
Mental status changes 14.23 10.72 185 111469 37898 34807379
Cholangitis 14.19 10.72 5 111649 8684 34836593
Hyperphagia 14.18 10.72 20 111634 1403 34843874
Terminal insomnia 14.03 10.72 13 111641 575 34844702
Jealous delusion 14.03 10.72 10 111644 303 34844974
Gallbladder polyp 14.01 10.72 11 111643 387 34844890
Gout 14.00 10.72 25 111629 19228 34826049
Deep vein thrombosis 13.96 10.72 137 111517 65111 34780166
Muscle spasticity 13.95 10.72 46 111608 5842 34839435
Akinesia 13.89 10.72 25 111629 2159 34843118
Incorrect route of product administration 13.84 10.72 88 111566 14757 34830520
CADASIL 13.83 10.72 7 111647 111 34845166
Facial bones fracture 13.73 10.72 27 111627 2493 34842784
Abdominal pain upper 13.71 10.72 154 111500 71336 34773941
Hallucinations, mixed 13.68 10.72 28 111626 2661 34842616
Hyperosmolar state 13.65 10.72 11 111643 402 34844875
Diverticulitis 13.64 10.72 27 111627 19977 34825300
Staphylococcal infection 13.64 10.72 56 111598 32704 34812573
Tachycardia 13.64 10.72 361 111293 84411 34760866
Intellectual disability 13.62 10.72 19 111635 1319 34843958
Purpura 13.62 10.72 8 111646 10303 34834974
Locomotive syndrome 13.49 10.72 4 111650 12 34845265
Monorchidism 13.49 10.72 4 111650 12 34845265
Wrong schedule 13.48 10.72 8 111646 176 34845101
Fatigue 13.42 10.72 1011 110643 369642 34475635
Ammonia abnormal 13.41 10.72 6 111648 71 34845206
Respiratory acidosis 13.38 10.72 41 111613 5009 34840268
Pneumonia bacterial 13.31 10.72 11 111643 11861 34833416
Urinary tract discomfort 13.29 10.72 7 111647 121 34845156
Niemann-Pick disease 13.25 10.72 4 111650 13 34845264
Drug level increased 13.24 10.72 118 111536 21978 34823299
Dissociation 13.23 10.72 21 111633 1637 34843640
Logorrhoea 13.23 10.72 26 111628 2400 34842877
Rectal haemorrhage 13.15 10.72 75 111579 40174 34805103
Epstein-Barr virus infection 13.14 10.72 4 111650 7624 34837653
Glossopharyngeal nerve disorder 13.11 10.72 5 111649 38 34845239
Social avoidant behaviour 13.07 10.72 30 111624 3084 34842193
Brain hypoxia 12.98 10.72 10 111644 342 34844935
Accommodation disorder 12.94 10.72 9 111645 262 34845015
Haematuria traumatic 12.90 10.72 8 111646 191 34845086
Blepharospasm 12.86 10.72 17 111637 1121 34844156
Congenital cerebral cyst 12.81 10.72 4 111650 15 34845262
Mutism 12.73 10.72 15 111639 880 34844397
Dependence 12.72 10.72 17 111637 1133 34844144
Cardiogenic shock 12.72 10.72 43 111611 26575 34818702
Mumps 12.71 10.72 6 111648 81 34845196
Cellulitis 12.70 10.72 108 111546 52843 34792434
Skin ulcer 12.70 10.72 33 111621 22183 34823094
Swelling face 12.70 10.72 35 111619 23070 34822207
Senile dementia 12.68 10.72 5 111649 42 34845235
Hypokinesia 12.58 10.72 59 111595 8821 34836456
Hyponatraemia 12.58 10.72 187 111467 82504 34762773
Bipolar I disorder 12.56 10.72 14 111640 773 34844504
Dementia 12.51 10.72 81 111573 13667 34831610
Lip swelling 12.50 10.72 20 111634 16060 34829217
Hyperreflexia 12.49 10.72 30 111624 3176 34842101
Blood osmolarity decreased 12.43 10.72 12 111642 559 34844718
Acute coronary syndrome 12.38 10.72 15 111639 13530 34831747
Malaise 12.33 10.72 477 111177 185348 34659929
Hypercalcaemia 12.25 10.72 19 111635 15449 34829828
Nervous system disorder 12.22 10.72 84 111570 14459 34830818
Substance use 12.21 10.72 13 111641 681 34844596
Hypothermia neonatal 12.21 10.72 6 111648 89 34845188
Oesophageal food impaction 12.21 10.72 6 111648 89 34845188
Product complaint 12.20 10.72 44 111610 5846 34839431
White blood cell analysis abnormal 12.18 10.72 3 111651 3 34845274
Medical device site scab 12.18 10.72 3 111651 3 34845274
Pseudodementia 12.18 10.72 3 111651 3 34845274
Muscle twitching 12.17 10.72 65 111589 10233 34835044
Communication disorder 12.16 10.72 26 111628 2548 34842729
Fibroma 12.12 10.72 10 111644 378 34844899
Haemoptysis 12.11 10.72 64 111590 34942 34810335
Lennox-Gastaut syndrome 12.10 10.72 5 111649 48 34845229
Rabbit syndrome 12.06 10.72 4 111650 19 34845258
Bladder dilatation 12.04 10.72 19 111635 1473 34843804
Post transplant lymphoproliferative disorder 12.04 10.72 3 111651 6525 34838752
Optic nerve operation 12.02 10.72 11 111643 479 34844798
Frustration tolerance decreased 12.01 10.72 26 111628 2570 34842707
Candida infection 12.00 10.72 24 111630 17691 34827586
Viral upper respiratory tract infection 12.00 10.72 27 111627 2739 34842538
Illusion 11.99 10.72 14 111640 813 34844464
Developmental hip dysplasia 11.99 10.72 9 111645 296 34844981
Allodynia 11.94 10.72 14 111640 817 34844460
Urinary incontinence 11.93 10.72 102 111552 18772 34826505
Hemiparesis 11.92 10.72 20 111634 15758 34829519
Dementia with Lewy bodies 11.89 10.72 13 111641 702 34844575
Anticonvulsant drug level decreased 11.86 10.72 16 111638 1076 34844201
Diet refusal 11.86 10.72 9 111645 301 34844976
Spasmodic dysphonia 11.84 10.72 8 111646 222 34845055
Renal injury 11.79 10.72 11 111643 11184 34834093
Nasal septum deviation 11.78 10.72 16 111638 1083 34844194
Jaundice 11.77 10.72 57 111597 31825 34813452
Confusional arousal 11.74 10.72 4 111650 21 34845256
Antisocial behaviour 11.70 10.72 10 111644 397 34844880
Somatic delusion 11.70 10.72 6 111648 98 34845179
Hypoxia 11.65 10.72 116 111538 54979 34790298
Hypoalbuminaemia 11.64 10.72 13 111641 12161 34833116
Paradoxical drug reaction 11.62 10.72 30 111624 3321 34841956
Mood altered 11.62 10.72 58 111596 8894 34836383
Pain 11.57 10.72 535 111119 204140 34641137
Open reduction of fracture 11.48 10.72 6 111648 102 34845175
Brain malformation 11.44 10.72 7 111647 163 34845114
Immunosuppression 11.43 10.72 3 111651 6301 34838976
Lung neoplasm malignant 11.42 10.72 24 111630 17371 34827906
C-reactive protein increased 11.40 10.72 114 111540 53984 34791293
Blood loss anaemia 11.34 10.72 6 111648 8188 34837089
Quadriparesis 11.33 10.72 19 111635 1550 34843727
Anaphylactic shock 11.32 10.72 21 111633 15920 34829357
Perineal infection 11.30 10.72 12 111642 627 34844650
Dissociative identity disorder 11.29 10.72 4 111650 24 34845253
Disseminated intravascular coagulation 11.29 10.72 34 111620 21782 34823495
Bulbar palsy 11.26 10.72 8 111646 241 34845036
Hyperhidrosis 11.23 10.72 319 111335 75373 34769904
Partial seizures with secondary generalisation 11.21 10.72 9 111645 327 34844950
Alopecia 11.19 10.72 40 111614 24315 34820962
Pyelonephritis 11.18 10.72 3 111651 6212 34839065
Pulmonary alveolar haemorrhage 11.15 10.72 5 111649 7507 34837770
Pneumonitis 11.14 10.72 63 111591 33815 34811462
Multiple sclerosis relapse 11.12 10.72 76 111578 13057 34832220
Infected dermal cyst 11.11 10.72 14 111640 880 34844397
Persistent depressive disorder 11.10 10.72 9 111645 332 34844945
Scrotal infection 11.08 10.72 12 111642 641 34844636
Drug eruption 11.04 10.72 30 111624 19868 34825409
Full blood count decreased 11.02 10.72 26 111628 18062 34827215
Blood pressure systolic increased 11.02 10.72 37 111617 22915 34822362
Appendicitis 10.97 10.72 19 111635 14788 34830489
Irregular sleep phase 10.97 10.72 5 111649 62 34845215
Sleep paralysis 10.93 10.72 7 111647 177 34845100
Pre-existing condition improved 10.91 10.72 25 111629 2567 34842710
Gastric haemorrhage 10.91 10.72 10 111644 10251 34835026
Antisocial personality disorder 10.90 10.72 5 111649 63 34845214
Medical device site dryness 10.89 10.72 4 111650 27 34845250
Schizoaffective disorder 10.85 10.72 17 111637 1310 34843967
Prostatic specific antigen increased 10.73 10.72 19 111635 14661 34830616
Hypervolaemia 10.72 10.72 30 111624 19679 34825598

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3442.21 9.80 4114 255614 241653 79243007
Drug abuse 1906.51 9.80 2494 257234 160197 79324463
Toxicity to various agents 1629.25 9.80 3968 255760 417572 79067088
Respiratory arrest 836.30 9.80 984 258744 56566 79428094
Depression 827.51 9.80 2034 257694 214756 79269904
Suicide attempt 822.69 9.80 1174 258554 81758 79402902
Intentional overdose 797.75 9.80 1320 258408 104640 79380020
Somnolence 717.69 9.80 2051 257677 236930 79247730
Sopor 697.21 9.80 688 259040 32322 79452338
Cardio-respiratory arrest 653.86 9.80 1226 258502 107284 79377376
Overdose 644.86 9.80 1673 258055 182533 79302127
Suicidal ideation 578.40 9.80 954 258774 75386 79409274
Psychotic disorder 523.53 9.80 660 259068 40742 79443918
Poisoning 452.52 9.80 482 259246 24790 79459870
Cardiac arrest 450.76 9.80 1408 258320 170688 79313972
Drug dependence 441.15 9.80 602 259126 40167 79444493
Seizure 429.94 9.80 1473 258255 187361 79297299
Drug withdrawal syndrome 422.42 9.80 543 259185 34175 79450485
Drug interaction 421.28 9.80 2548 257180 412635 79072025
Neuroleptic malignant syndrome 418.21 9.80 482 259246 27077 79457583
Synovitis 404.18 9.80 21 259707 150713 79333947
Anxiety 377.71 9.80 1707 258021 246805 79237855
Contraindicated product administered 371.47 9.80 40 259688 157498 79327162
Coma 367.22 9.80 929 258799 99720 79384940
Intentional self-injury 366.42 9.80 489 259239 31930 79452730
Agitation 357.16 9.80 914 258814 98801 79385859
Aggression 337.41 9.80 600 259128 50358 79434302
Acute kidney injury 307.89 9.80 782 258946 518622 78966038
Febrile neutropenia 305.66 9.80 187 259541 230812 79253848
Abnormal behaviour 295.95 9.80 470 259258 35951 79448709
Drug intolerance 294.66 9.80 256 259472 263863 79220797
Intentional product misuse 291.15 9.80 823 258905 94342 79390318
Miosis 284.18 9.80 302 259426 15487 79469173
Infusion related reaction 275.72 9.80 208 259520 230029 79254631
Depressed level of consciousness 271.76 9.80 811 258917 95841 79388819
Anaemia 262.82 9.80 671 259057 444344 79040316
Hand deformity 262.09 9.80 20 259708 103899 79380761
Panic attack 253.54 9.80 352 259376 23864 79460796
Schizophrenia 249.44 9.80 279 259449 15161 79469499
Stubbornness 247.58 9.80 79 259649 316 79484344
Serotonin syndrome 246.78 9.80 489 259239 44538 79440122
Psychiatric decompensation 243.22 9.80 155 259573 3808 79480852
Tremor 241.71 9.80 1146 258582 168937 79315723
Joint swelling 239.08 9.80 356 259372 288290 79196370
Pericarditis 236.89 9.80 30 259698 104206 79380454
Systemic lupus erythematosus 233.41 9.80 54 259674 121095 79363565
Rash 232.12 9.80 1032 258696 577326 78907334
Dyskinesia 231.96 9.80 475 259253 44298 79440362
Paranoia 230.21 9.80 300 259428 19132 79465528
Arthropathy 223.82 9.80 151 259577 176960 79307700
General physical health deterioration 215.03 9.80 353 259375 274885 79209775
Substance abuse 212.25 9.80 214 259514 10312 79474348
Speech disorder 209.49 9.80 513 259215 53932 79430728
Rheumatoid arthritis 196.09 9.80 234 259494 208236 79276424
Thinking abnormal 195.98 9.80 228 259500 12933 79471727
Helicobacter infection 195.77 9.80 7 259721 69697 79414963
Sedation 195.46 9.80 485 259243 51410 79433250
Glossodynia 195.25 9.80 48 259680 103289 79381371
Mydriasis 193.05 9.80 262 259466 17381 79467279
Irritability 192.82 9.80 419 259309 40725 79443935
Ataxia 190.98 9.80 314 259414 24725 79459935
Insomnia 181.90 9.80 1394 258334 243776 79240884
Hypersensitivity 175.04 9.80 370 259358 261869 79222791
Treatment failure 173.91 9.80 179 259549 170307 79314353
Stomatitis 171.27 9.80 136 259592 146621 79338039
Altered state of consciousness 168.68 9.80 413 259315 43409 79441251
Thrombocytopenia 168.21 9.80 385 259343 264874 79219786
Rheumatoid factor positive 168.08 9.80 6 259722 59833 79424827
Drug withdrawal convulsions 167.31 9.80 99 259629 2121 79482539
Unresponsive to stimuli 166.21 9.80 478 259250 55310 79429350
Alopecia 163.28 9.80 316 259412 231039 79253621
Diarrhoea 162.64 9.80 1962 257766 878527 78606133
Dystonia 158.70 9.80 265 259463 21134 79463526
Sensitisation 158.60 9.80 111 259617 3200 79481460
Infection 157.18 9.80 346 259382 241366 79243294
Status epilepticus 156.99 9.80 288 259440 24753 79459907
Pancytopenia 155.89 9.80 186 259542 165559 79319101
Mental disorder 154.99 9.80 326 259402 30976 79453684
Muscle rigidity 153.89 9.80 251 259477 19631 79465029
Sepsis 152.93 9.80 414 259314 269014 79215646
Disease progression 152.92 9.80 227 259501 184135 79300525
Atrial fibrillation 152.44 9.80 256 259472 197630 79287030
Polycystic ovaries 152.08 9.80 114 259614 3665 79480995
Swelling 152.06 9.80 297 259431 216414 79268246
Withdrawal syndrome 149.98 9.80 294 259434 26560 79458100
Tardive dyskinesia 148.90 9.80 178 259550 10393 79474267
Neutropenia 148.78 9.80 462 259266 287248 79197412
Hallucination 145.28 9.80 609 259119 85136 79399524
Interstitial lung disease 143.56 9.80 95 259633 112505 79372155
Malignant neoplasm progression 143.01 9.80 139 259589 135851 79348809
Bradyphrenia 141.46 9.80 174 259554 10466 79474194
Psychomotor skills impaired 139.06 9.80 124 259604 5113 79479547
Depression suicidal 137.31 9.80 108 259620 3734 79480926
Tearfulness 136.98 9.80 131 259597 5914 79478746
Impaired healing 133.57 9.80 59 259669 87596 79397064
Mania 131.25 9.80 223 259505 18037 79466623
Drug hypersensitivity 131.02 9.80 515 259213 298401 79186259
Ejection fraction 130.02 9.80 85 259643 2184 79482476
Pneumonia aspiration 129.76 9.80 496 259232 66471 79418189
Abdominal discomfort 129.34 9.80 403 259325 250324 79234336
Folliculitis 128.12 9.80 15 259713 55365 79429295
Wound 127.76 9.80 114 259614 116065 79368595
Crying 124.73 9.80 249 259479 22794 79461866
Feeling of despair 124.57 9.80 90 259638 2731 79481929
Granulocytopenia 122.41 9.80 168 259560 11263 79473397
Restlessness 122.08 9.80 381 259347 46111 79438549
Restless legs syndrome 120.84 9.80 227 259501 19865 79464795
Bradykinesia 119.19 9.80 139 259589 7904 79476756
On and off phenomenon 117.78 9.80 92 259636 3148 79481512
Rhinitis allergic 117.59 9.80 171 259557 12098 79472562
Disturbance in attention 116.90 9.80 398 259330 50403 79434257
Drooling 116.64 9.80 119 259609 5815 79478845
Arthralgia 116.32 9.80 1246 258482 570557 78914103
Renal impairment 116.15 9.80 210 259518 157573 79327087
Hallucination, auditory 116.10 9.80 227 259501 20466 79464194
Dysarthria 115.88 9.80 482 259246 67140 79417520
Platelet count decreased 115.85 9.80 292 259436 194372 79290288
Mood altered 115.35 9.80 208 259520 17639 79467021
Parkinsonism 114.56 9.80 199 259529 16385 79468275
Depressive symptom 114.07 9.80 122 259606 6301 79478359
Anger 112.18 9.80 201 259527 16961 79467699
Generalised tonic-clonic seizure 111.77 9.80 356 259372 43554 79441106
Off label use 111.49 9.80 2185 257543 905030 78579630
Maternal exposure during pregnancy 111.38 9.80 170 259558 136368 79348292
Pleural effusion 110.85 9.80 189 259539 145073 79339587
Gastrointestinal haemorrhage 108.37 9.80 197 259531 147522 79337138
Akathisia 107.54 9.80 171 259557 13088 79471572
Salivary hypersecretion 105.28 9.80 176 259552 14048 79470612
Respiratory depression 103.78 9.80 258 259470 27372 79457288
Loss of consciousness 100.96 9.80 911 258817 167032 79317628
Cogwheel rigidity 100.14 9.80 82 259646 3006 79481654
Therapeutic product effect decreased 99.68 9.80 243 259485 163620 79321040
Muscle injury 98.94 9.80 19 259709 48542 79436118
Balance disorder 98.73 9.80 605 259123 98252 79386408
Hyperkalaemia 98.63 9.80 137 259591 114261 79370399
Dyspnoea 98.42 9.80 2087 257641 854938 78629722
Myelosuppression 98.16 9.80 9 259719 40287 79444373
Psychomotor hyperactivity 95.95 9.80 186 259542 16663 79467997
Cardiac failure 95.47 9.80 228 259500 154614 79330046
Dissociation 94.66 9.80 89 259639 3932 79480728
Delusion 92.29 9.80 205 259523 20218 79464442
Multiple sclerosis 92.20 9.80 216 259512 22066 79462594
Pyrexia 91.51 9.80 1608 258120 677101 78807559
Drug use disorder 90.92 9.80 126 259602 8525 79476135
Myoglobin urine present 89.60 9.80 49 259679 898 79483762
Gait disturbance 88.72 9.80 1050 258678 206456 79278204
Mucosal inflammation 86.95 9.80 71 259657 75509 79409151
Catatonia 86.78 9.80 124 259604 8632 79476028
Epilepsy 84.44 9.80 309 259419 40551 79444109
Gastric pH decreased 84.26 9.80 46 259682 840 79483820
Memory impairment 84.24 9.80 638 259090 111096 79373564
Peripheral swelling 83.32 9.80 525 259203 269092 79215568
Drug abuser 82.64 9.80 100 259628 5913 79478747
Middle insomnia 82.64 9.80 170 259558 15899 79468761
Disorientation 82.62 9.80 414 259314 62362 79422298
Hypersomnia 81.94 9.80 211 259517 22875 79461785
Bone marrow failure 81.72 9.80 32 259696 51075 79433585
Feeling abnormal 81.56 9.80 835 258893 158364 79326296
Lactic acidosis 81.06 9.80 66 259662 70293 79414367
Psychomotor retardation 80.39 9.80 100 259628 6084 79478576
Discomfort 79.81 9.80 182 259546 125435 79359225
Multiple-drug resistance 79.00 9.80 119 259609 8689 79475971
Renal failure 78.90 9.80 361 259367 200607 79284053
Hyperprolactinaemia 78.11 9.80 86 259642 4590 79480070
Bipolar disorder 77.65 9.80 110 259618 7597 79477063
Myocardial infarction 77.61 9.80 322 259406 183807 79300853
Blood creatinine increased 77.27 9.80 253 259475 154804 79329856
Hepatic enzyme increased 77.18 9.80 319 259409 182291 79302369
Stoma site discharge 76.59 9.80 61 259667 2148 79482512
Rheumatic fever 76.34 9.80 4 259724 28521 79456139
Sleep apnoea syndrome 76.34 9.80 277 259451 36201 79448459
Derealisation 76.01 9.80 54 259674 1595 79483065
Lower respiratory tract infection 75.95 9.80 195 259533 129025 79355635
Melaena 75.42 9.80 53 259675 60837 79423823
Victim of crime 74.81 9.80 35 259693 453 79484207
Urinary tract discomfort 74.73 9.80 40 259688 701 79483959
Cytomegalovirus infection 74.56 9.80 23 259705 42621 79442039
Nervousness 74.43 9.80 259 259469 33156 79451504
Cardiac failure congestive 73.30 9.80 229 259499 142173 79342487
Nightmare 72.62 9.80 217 259511 25644 79459016
Hyperhidrosis 72.62 9.80 784 258944 150708 79333952
Toxic encephalopathy 72.24 9.80 132 259596 11308 79473352
Irritable bowel syndrome 70.94 9.80 59 259669 62182 79422478
Blood creatine phosphokinase increased 70.80 9.80 412 259316 65678 79418982
Angioedema 70.74 9.80 86 259642 75949 79408711
Anticonvulsant drug level above therapeutic 69.88 9.80 45 259683 1126 79483534
Alveolar osteitis 69.81 9.80 40 259688 805 79483855
Ascites 69.73 9.80 86 259642 75476 79409184
Septic shock 69.37 9.80 189 259539 122612 79362048
Movement disorder 69.36 9.80 221 259507 27038 79457622
Emotional disorder 69.09 9.80 148 259580 14239 79470421
Haematochezia 67.80 9.80 113 259615 87532 79397128
Exposure via ingestion 67.80 9.80 84 259644 5090 79479570
Mood swings 67.79 9.80 179 259549 19701 79464959
Hypokinesia 67.44 9.80 174 259554 18886 79465774
Depersonalisation/derealisation disorder 65.81 9.80 52 259676 1810 79482850
Mental impairment 65.53 9.80 172 259556 18864 79465796
Fall 65.50 9.80 2064 257664 485565 78999095
Sleep disorder due to general medical condition, insomnia type 65.28 9.80 30 259698 43526 79441134
Multiple sclerosis relapse 64.88 9.80 312 259416 46221 79438439
Electrocardiogram QRS complex prolonged 64.65 9.80 122 259606 10711 79473949
COVID-19 64.43 9.80 279 259449 157395 79327265
Hypoaesthesia oral 64.07 9.80 142 259586 13982 79470678
Electroencephalogram abnormal 62.97 9.80 83 259645 5351 79479309
Inflammation 62.71 9.80 132 259596 93621 79391039
Pulmonary fibrosis 62.15 9.80 33 259695 44079 79440581
Pneumocystis jirovecii pneumonia 61.58 9.80 15 259713 32493 79452167
C-reactive protein increased 60.56 9.80 216 259512 128811 79355849
Electrocardiogram QT prolonged 60.39 9.80 502 259226 89884 79394776
Loss of personal independence in daily activities 60.36 9.80 554 259174 102026 79382634
Mental status changes 60.17 9.80 399 259329 66560 79418100
Carpal tunnel syndrome 58.80 9.80 168 259560 19360 79465300
Jaundice cholestatic 58.76 9.80 120 259608 11164 79473496
Bradypnoea 57.49 9.80 84 259644 5968 79478692
Urticaria 56.99 9.80 361 259367 184840 79299820
Feeling of body temperature change 56.61 9.80 78 259650 5248 79479412
Dopamine dysregulation syndrome 55.23 9.80 29 259699 488 79484172
Musculoskeletal pain 54.52 9.80 162 259566 102192 79382468
Animal scratch 53.90 9.80 42 259686 1432 79483228
Bladder pain 53.63 9.80 51 259677 2286 79482374
Stoma site erythema 53.62 9.80 45 259683 1708 79482952
Neuropathy peripheral 53.57 9.80 257 259471 141048 79343612
Drug screen positive 53.08 9.80 81 259647 5982 79478678
Burning sensation 53.06 9.80 350 259378 58282 79426378
Myoclonic epilepsy 53.01 9.80 47 259681 1923 79482737
Red blood cell sedimentation rate abnormal 52.94 9.80 4 259724 20959 79463701
Dysphoria 52.85 9.80 71 259657 4663 79479997
Haemoglobin decreased 52.61 9.80 466 259262 221653 79263007
Galactorrhoea 52.35 9.80 62 259666 3584 79481076
Hypercalcaemia 52.33 9.80 30 259698 38400 79446260
Cytokine release syndrome 52.10 9.80 26 259702 35972 79448688
Neutrophil count decreased 52.03 9.80 146 259582 93813 79390847
Incontinence 51.87 9.80 131 259597 14033 79470627
Ill-defined disorder 51.82 9.80 84 259644 65791 79418869
Colitis 51.77 9.80 100 259628 73207 79411453
Tunnel vision 51.37 9.80 42 259686 1536 79483124
Erythema 51.34 9.80 472 259256 222818 79261842
Transplant rejection 51.17 9.80 3 259725 19434 79465226
Palmar-plantar erythrodysaesthesia syndrome 50.95 9.80 22 259706 33112 79451548
Abnormal dreams 50.94 9.80 114 259614 11298 79473362
Proteinuria 50.90 9.80 21 259707 32481 79452179
Hyperammonaemia 50.86 9.80 112 259616 10981 79473679
Tension 50.62 9.80 67 259661 4337 79480323
Lethargy 50.36 9.80 444 259284 80848 79403812
Neutropenic sepsis 50.28 9.80 13 259715 27051 79457609
Amnesia 49.75 9.80 364 259364 62693 79421967
Pruritus 49.59 9.80 946 258782 393702 79090958
Multiple organ dysfunction syndrome 49.59 9.80 212 259516 120034 79364626
Hallucinations, mixed 49.24 9.80 84 259644 6815 79477845
Nystagmus 48.85 9.80 103 259625 9801 79474859
Myoclonus 48.82 9.80 199 259529 27461 79457199
Nasopharyngitis 48.78 9.80 560 259168 253321 79231339
Myocardial stunning 48.66 9.80 20 259708 185 79484475
Acute myocardial infarction 48.61 9.80 112 259616 76924 79407736
Hip arthroplasty 48.56 9.80 28 259700 35728 79448932
Feeling jittery 48.32 9.80 120 259608 12721 79471939
Blood test abnormal 48.22 9.80 147 259581 17563 79467097
Personality disorder 48.11 9.80 78 259650 6068 79478592
Therapeutic product ineffective 48.06 9.80 44 259684 1878 79482782
Knee arthroplasty 48.05 9.80 42 259686 43206 79441454
Confusional state 48.03 9.80 1366 258362 316631 79168029
Upper gastrointestinal haemorrhage 47.43 9.80 39 259689 41341 79443319
Gastrointestinal disorder 47.06 9.80 221 259507 121984 79362676
Breast hyperplasia 46.95 9.80 18 259710 136 79484524
Menstrual disorder 46.94 9.80 62 259666 4005 79480655
Nasal polyps 46.85 9.80 85 259643 7242 79477418
Drug screen negative 46.67 9.80 22 259706 290 79484370
Accidental overdose 46.53 9.80 253 259475 39328 79445332
Sleep-related eating disorder 46.50 9.80 29 259699 685 79483975
Posture abnormal 46.28 9.80 60 259668 3806 79480854
Depressed mood 46.07 9.80 293 259435 48187 79436473
Housebound 46.06 9.80 25 259703 451 79484209
Hypocalcaemia 45.87 9.80 57 259671 49867 79434793
Rubber sensitivity 45.62 9.80 41 259687 1708 79482952
Sluggishness 45.57 9.80 79 259649 6493 79478167
Blister 45.46 9.80 217 259511 119259 79365401
Tumour lysis syndrome 45.44 9.80 11 259717 23928 79460732
Head injury 45.38 9.80 241 259487 37128 79447532
Hypothermia 45.30 9.80 170 259558 22576 79462084
Behaviour disorder 45.24 9.80 77 259651 6236 79478424
Hypomagnesaemia 44.76 9.80 52 259676 46859 79437801
Decorticate posture 44.75 9.80 22 259706 320 79484340
Rash pruritic 44.50 9.80 105 259623 71524 79413136
Nephrectomy 44.48 9.80 44 259684 2071 79482589
Osteonecrosis of jaw 44.48 9.80 45 259683 43181 79441479
Nausea 44.45 9.80 2609 257119 954587 78530073
Neoplasm progression 44.43 9.80 62 259666 51620 79433040
Accidental death 44.35 9.80 62 259666 4229 79480431
Herpes zoster 44.23 9.80 155 259573 92928 79391732
Mobility decreased 44.13 9.80 226 259502 121949 79362711
Hypoventilation 43.91 9.80 82 259646 7142 79477518
Hypertension 43.87 9.80 786 258942 330206 79154454
Anaphylactic reaction 43.55 9.80 134 259594 83609 79401051
H1N1 influenza 43.25 9.80 47 259681 2472 79482188
Hostility 43.01 9.80 45 259683 2265 79482395
Bronchopulmonary aspergillosis 42.79 9.80 10 259718 22284 79462376
Ejection fraction abnormal 42.72 9.80 46 259682 2394 79482266
Freezing phenomenon 42.46 9.80 41 259687 1873 79482787
Screaming 42.41 9.80 58 259670 3875 79480785
Sleep disorder due to a general medical condition 42.19 9.80 122 259606 14155 79470505
Autonomic nervous system imbalance 42.16 9.80 63 259665 4567 79480093
Suspected suicide 42.10 9.80 101 259627 10475 79474185
Psoriatic arthropathy 41.86 9.80 123 259605 77876 79406784
Atonic seizures 41.84 9.80 28 259700 749 79483911
Plasma cell myeloma 41.81 9.80 68 259660 53191 79431469
Cytopenia 41.47 9.80 8 259720 20375 79464285
Stereotypy 41.39 9.80 30 259698 915 79483745
Myocardial depression 40.94 9.80 24 259704 505 79484155
Libido increased 40.92 9.80 41 259687 1960 79482700
Cognitive disorder 40.80 9.80 377 259351 69549 79415111
Acute myeloid leukaemia 40.80 9.80 25 259703 30860 79453800
Skin ulcer 40.79 9.80 71 259657 54079 79430581
Extrapyramidal disorder 40.69 9.80 164 259564 22515 79462145
Cerebral haemorrhage 40.44 9.80 79 259649 57594 79427066
Device interaction 40.32 9.80 27 259701 723 79483937
Arthritis 40.09 9.80 215 259513 114665 79369995
Prostate cancer 39.84 9.80 30 259698 33238 79451422
Toxicologic test abnormal 39.73 9.80 34 259694 1326 79483334
Hallucination, visual 39.69 9.80 211 259517 32518 79452142
Creatinine renal clearance decreased 39.64 9.80 7 259721 18995 79465665
Red blood cell sedimentation rate increased 39.60 9.80 55 259673 45887 79438773
Major depression 39.30 9.80 89 259639 8891 79475769
Antipsychotic drug level increased 39.23 9.80 70 259658 5887 79478773
Broncholithiasis 39.10 9.80 18 259710 224 79484436
Weight abnormal 39.06 9.80 36 259692 1550 79483110
Bone erosion 38.51 9.80 6 259722 17841 79466819
Shock haemorrhagic 38.50 9.80 9 259719 20051 79464609
Product substitution issue 38.38 9.80 149 259579 20107 79464553
Libido decreased 38.26 9.80 65 259663 5256 79479404
Myelodysplastic syndrome 38.02 9.80 26 259702 30275 79454385
Cerebellar atrophy 38.00 9.80 31 259697 1130 79483530
Aspergillus infection 37.98 9.80 8 259720 19153 79465507
Dystonic tremor 37.62 9.80 17 259711 202 79484458
Epistaxis 37.11 9.80 212 259516 111303 79373357
Migraine 37.03 9.80 442 259286 87051 79397609
Paranasal sinus discomfort 36.87 9.80 58 259670 4398 79480262
Liver disorder 36.86 9.80 117 259611 72300 79412360
Torticollis 36.62 9.80 42 259686 2345 79482315
Areflexia 36.40 9.80 65 259663 5469 79479191
Tubulointerstitial nephritis 35.82 9.80 43 259685 38192 79446468
Cerebrovascular accident 35.36 9.80 329 259399 154963 79329697
Persecutory delusion 35.34 9.80 60 259668 4849 79479811
Basal cell carcinoma 35.05 9.80 42 259686 37333 79447327
Thrombotic microangiopathy 35.04 9.80 11 259717 20158 79464502
Priapism 35.03 9.80 57 259671 4448 79480212
Adrenal insufficiency 35.01 9.80 25 259703 28462 79456198
Drug level above therapeutic 34.40 9.80 83 259645 8640 79476020
Anaphylactic shock 34.24 9.80 40 259688 35956 79448704
Vision blurred 34.05 9.80 509 259219 105389 79379271
Adverse drug reaction 33.98 9.80 107 259621 66285 79418375
Agoraphobia 33.97 9.80 22 259706 556 79484104
Delirium 33.85 9.80 423 259305 84204 79400456
Dyspnoea exertional 33.79 9.80 157 259571 86916 79397744
Disinhibition 33.75 9.80 42 259686 2556 79482104
Hyperthermia 33.62 9.80 132 259596 17905 79466755
Panic disorder 33.59 9.80 45 259683 2947 79481713
Liver injury 33.59 9.80 85 259643 56529 79428131
Impaired driving ability 33.58 9.80 62 259666 5353 79479307
Mutism 33.50 9.80 40 259688 2332 79482328
Affect lability 33.07 9.80 96 259632 11163 79473497
Pathogen resistance 32.89 9.80 4 259724 14338 79470322
Total lung capacity increased 32.86 9.80 39 259689 2259 79482401
Partial seizures 32.84 9.80 83 259645 8895 79475765
Osmolar gap increased 32.64 9.80 13 259715 110 79484550
Abdominal pain 32.57 9.80 993 258735 388576 79096084
Fear 32.53 9.80 150 259578 21836 79462824
Coordination abnormal 32.52 9.80 127 259601 17185 79467475
Aplastic anaemia 32.50 9.80 9 259719 17896 79466764
Coronary artery disease 32.48 9.80 107 259621 65367 79419293
Decompression sickness 32.33 9.80 12 259716 82 79484578
Incoherent 32.30 9.80 75 259653 7617 79477043
Accidental poisoning 32.15 9.80 33 259695 1624 79483036
Therapy non-responder 32.07 9.80 173 259555 92132 79392528
Adjustment disorder with mixed anxiety and depressed mood 32.04 9.80 13 259715 116 79484544
Oromandibular dystonia 32.03 9.80 27 259701 1031 79483629
Obsessive-compulsive disorder 32.02 9.80 64 259664 5863 79478797
Hypertonia 32.01 9.80 72 259656 7160 79477500
Asthma 32.00 9.80 618 259110 134477 79350183
Gaze palsy 31.93 9.80 44 259684 2961 79481699
Encephalopathy 31.90 9.80 348 259380 67049 79417611
Hyponatraemia 31.58 9.80 399 259329 177449 79307211
Oedema peripheral 31.57 9.80 605 259123 251683 79232977
Abdominal pain upper 31.40 9.80 526 259202 223293 79261367
Haematemesis 31.37 9.80 78 259650 52186 79432474
Psychogenic seizure 31.37 9.80 35 259693 1896 79482764
Secretion discharge 31.37 9.80 114 259614 14908 79469752
Withdrawal arrhythmia 31.34 9.80 10 259718 40 79484620
Hypokalaemia 31.16 9.80 309 259419 143731 79340929
Emotional distress 31.11 9.80 230 259498 39739 79444921
Right ventricular failure 31.07 9.80 19 259709 23478 79461182
Pneumonia 30.84 9.80 1798 257930 658448 78826212
Influenza like illness 30.67 9.80 363 259365 71344 79413316
Rapid eye movement sleep behaviour disorder 30.54 9.80 19 259709 447 79484213
International normalised ratio increased 30.43 9.80 157 259571 84564 79400096
Encephalitis toxic 30.07 9.80 16 259712 277 79484383
Drug diversion 30.06 9.80 28 259700 1222 79483438
Pleurothotonus 30.04 9.80 39 259689 2477 79482183
Coma blister 30.04 9.80 15 259713 226 79484434
Bruxism 30.04 9.80 50 259678 3976 79480684
Psychiatric symptom 29.98 9.80 69 259659 6966 79477694
Lymph node calcification 29.96 9.80 18 259710 397 79484263
Ear congestion 29.91 9.80 42 259686 2877 79481783
Parasomnia 29.69 9.80 20 259708 541 79484119
Heat stroke 29.63 9.80 32 259696 1671 79482989
Bacteraemia 29.61 9.80 38 259690 32786 79451874
Asthma-chronic obstructive pulmonary disease overlap syndrome 29.58 9.80 44 259684 3177 79481483
Urinary retention 29.43 9.80 298 259430 56332 79428328
Stoma site extravasation 29.41 9.80 17 259711 348 79484312
Treatment noncompliance 29.09 9.80 279 259449 51989 79432671
Heart rate increased 28.85 9.80 553 259175 120171 79364489
Stoma site hypergranulation 28.80 9.80 18 259710 427 79484233
Hypervolaemia 28.63 9.80 60 259668 42630 79442030
Sinus pain 28.63 9.80 47 259681 3695 79480965
Substance use disorder 28.53 9.80 24 259704 914 79483746
Limb injury 28.39 9.80 179 259549 29349 79455311
Vessel puncture site erythema 28.38 9.80 6 259722 0 79484660
Liver function test increased 28.30 9.80 54 259674 39719 79444941
Muscle twitching 28.24 9.80 157 259571 24607 79460053
Stoma site pain 28.22 9.80 29 259699 1429 79483231
Rectal haemorrhage 28.20 9.80 140 259588 76160 79408500
Cholestasis 28.09 9.80 82 259646 52027 79432633
Feeling guilty 28.04 9.80 23 259705 845 79483815
Diverticulitis 28.01 9.80 68 259660 45868 79438792
Haematotoxicity 27.80 9.80 8 259720 15511 79469149
Sinus tachycardia 27.38 9.80 210 259518 36698 79447962
Urinary incontinence 27.20 9.80 227 259501 40682 79443978
Impulsive behaviour 27.18 9.80 40 259688 2860 79481800
Reduced facial expression 27.17 9.80 39 259689 2726 79481934
Concussion 26.93 9.80 80 259648 9423 79475237
Ehlers-Danlos syndrome 26.90 9.80 12 259716 138 79484522
Band neutrophil percentage increased 26.88 9.80 17 259711 412 79484248
Parosmia 26.87 9.80 66 259662 6948 79477712
Euphoric mood 26.78 9.80 70 259658 7656 79477004
Schizoaffective disorder 26.70 9.80 34 259694 2118 79482542
Stress 26.51 9.80 385 259343 79227 79405433
Somnambulism 26.50 9.80 58 259670 5663 79478997
Coma scale abnormal 26.46 9.80 75 259653 8603 79476057
Osteoporosis 26.45 9.80 89 259639 54023 79430637
Respiratory rate decreased 26.41 9.80 55 259673 5188 79479472
Wrong patient received product 26.32 9.80 51 259677 4567 79480093
Urinary bladder rupture 26.28 9.80 11 259717 107 79484553
Parkinsonian gait 26.27 9.80 23 259705 925 79483735
Oropharyngeal oedema 26.27 9.80 17 259711 429 79484231
Blood prolactin increased 26.24 9.80 47 259681 3964 79480696
Change in seizure presentation 26.17 9.80 18 259710 504 79484156
Blood creatine phosphokinase 26.09 9.80 12 259716 149 79484511
Tachyphrenia 26.03 9.80 33 259695 2047 79482613
Attention deficit hyperactivity disorder 25.91 9.80 42 259686 3267 79481393
Ketosis-prone diabetes mellitus 25.90 9.80 8 259720 28 79484632
Apathy 25.85 9.80 97 259631 12880 79471780
Logorrhoea 25.85 9.80 49 259679 4316 79480344
Fluid retention 25.28 9.80 129 259599 69680 79414980
Pulmonary hypertension 24.95 9.80 77 259651 48003 79436657
Upper respiratory tract infection 24.90 9.80 184 259544 90984 79393676
Hyperkinesia 24.66 9.80 37 259691 2692 79481968
Hypotonia 24.65 9.80 95 259633 12775 79471885
Pain 24.62 9.80 1966 257762 701836 78782824
Jaundice 24.57 9.80 90 259638 53259 79431401
Drug tolerance decreased 24.56 9.80 6 259722 12972 79471688
Poor quality sleep 24.55 9.80 142 259586 22580 79462080
Pulmonary arterial hypertension 24.41 9.80 34 259694 28332 79456328
Anorgasmia 24.38 9.80 25 259703 1229 79483431
Muscle disorder 24.35 9.80 56 259672 5651 79479009
Post-traumatic neck syndrome 24.29 9.80 32 259696 2062 79482598
Nasal oedema 24.23 9.80 29 259699 1695 79482965
Diffuse large B-cell lymphoma 24.23 9.80 5 259723 12144 79472516
Bronchopulmonary aspergillosis allergic 24.17 9.80 39 259689 3022 79481638
Hyperreflexia 24.15 9.80 71 259657 8314 79476346
Device dislocation 24.08 9.80 156 259572 25814 79458846
Disorganised speech 24.01 9.80 32 259696 2085 79482575
Lymphopenia 24.00 9.80 39 259689 30518 79454142
Haematuria 23.92 9.80 129 259599 68707 79415953
Thrombosis 23.81 9.80 168 259560 83932 79400728
Post-anoxic myoclonus 23.80 9.80 8 259720 39 79484621
Squamous cell carcinoma of skin 23.77 9.80 8 259720 14025 79470635
Nephropathy toxic 23.71 9.80 19 259709 20400 79464260
Hyperphagia 23.63 9.80 35 259693 2517 79482143
Panic reaction 23.57 9.80 49 259679 4616 79480044
Impulse-control disorder 23.56 9.80 29 259699 1745 79482915
Stupor 23.56 9.80 62 259666 6810 79477850
Chronic kidney disease 23.53 9.80 123 259605 66031 79418629
Disseminated intravascular coagulation 23.51 9.80 51 259677 35791 79448869
Hepatic cirrhosis 23.46 9.80 49 259679 34857 79449803
Lupus-like syndrome 23.29 9.80 8 259720 13849 79470811
Lung disorder 23.26 9.80 160 259568 80397 79404263
Brain scan abnormal 23.09 9.80 24 259704 1199 79483461
Self-injurious ideation 23.00 9.80 42 259686 3596 79481064
Failure to suspend medication 22.96 9.80 16 259712 458 79484202
Aphasia 22.90 9.80 243 259485 46489 79438171
Enthesopathy 22.69 9.80 5 259723 11603 79473057
Postmortem blood drug level abnormal 22.55 9.80 18 259710 636 79484024
Rash maculo-papular 22.42 9.80 100 259628 55978 79428682
Clostridium difficile infection 22.41 9.80 68 259660 42617 79442043
Bipolar I disorder 22.36 9.80 31 259697 2098 79482562
Dysstasia 22.36 9.80 161 259567 27585 79457075
Drug eruption 22.35 9.80 71 259657 43864 79440796
Post transplant lymphoproliferative disorder 22.29 9.80 5 259723 11459 79473201
Visceral congestion 22.20 9.80 21 259707 935 79483725
Product use issue 22.19 9.80 517 259211 209305 79275355
Weight increased 22.08 9.80 1110 258618 276276 79208384
Stoma site infection 22.08 9.80 26 259702 1494 79483166
Substance dependence 22.07 9.80 16 259712 488 79484172
Osteoarthritis 22.07 9.80 180 259548 87129 79397531
Post-traumatic stress disorder 22.06 9.80 49 259679 4832 79479828
Psychotic disorder due to a general medical condition 21.99 9.80 13 259715 278 79484382
White blood cell count decreased 21.90 9.80 457 259271 187831 79296829
Food craving 21.87 9.80 27 259701 1630 79483030
Cholelithiasis 21.82 9.80 265 259463 52399 79432261
Sebaceous gland infection 21.72 9.80 11 259717 171 79484489
Testicular infarction 21.64 9.80 8 259720 54 79484606
Stoma site inflammation 21.56 9.80 18 259710 678 79483982
Tinnitus 21.48 9.80 230 259498 44103 79440557
Acute generalised exanthematous pustulosis 21.39 9.80 15 259713 17239 79467421
Hereditary angioedema 21.29 9.80 51 259677 5284 79479376
Leukopenia 21.20 9.80 260 259468 116253 79368407
Suicidal behaviour 21.18 9.80 38 259690 3209 79481451
Anion gap increased 21.10 9.80 41 259687 3679 79480981
Live birth 21.07 9.80 18 259710 18726 79465934
Haemophagocytic lymphohistiocytosis 21.06 9.80 24 259704 21813 79462847
Psychotic behaviour 21.03 9.80 22 259706 1107 79483553
Sensory loss 21.00 9.80 91 259637 12900 79471760
Kidney transplant rejection 20.89 9.80 4 259724 10242 79474418
Physical assault 20.86 9.80 26 259702 1585 79483075
Clonus 20.74 9.80 59 259669 6781 79477879
Atrial flutter 20.60 9.80 24 259704 21601 79463059
Dysphemia 20.50 9.80 39 259689 3445 79481215
Seizure cluster 20.48 9.80 14 259714 388 79484272
Blood iron decreased 20.45 9.80 102 259626 15332 79469328
Cholangitis 20.42 9.80 8 259720 12768 79471892
Onychophagia 20.37 9.80 9 259719 101 79484559
Soft tissue injury 20.32 9.80 27 259701 1754 79482906
Social anxiety disorder 20.29 9.80 16 259712 555 79484105
Graft versus host disease 20.07 9.80 12 259716 15014 79469646
Transfusion 19.97 9.80 24 259704 21306 79463354
Dehydration 19.90 9.80 636 259092 247551 79237109
Haemoglobin urine 19.89 9.80 10 259718 153 79484507
Cerebral infarction 19.78 9.80 79 259649 45597 79439063
Postoperative respiratory failure 19.67 9.80 11 259717 211 79484449
Compartment syndrome 19.66 9.80 48 259680 5034 79479626
Phaeochromocytoma malignant 19.66 9.80 8 259720 72 79484588
CADASIL 19.63 9.80 7 259721 42 79484618
Parotid gland enlargement 19.59 9.80 20 259708 978 79483682
Immunosuppressant drug level increased 19.56 9.80 3 259725 9024 79475636
Pneumonitis 19.55 9.80 117 259611 60743 79423917
Acute coronary syndrome 19.55 9.80 24 259704 21109 79463551
Prescribed overdose 19.52 9.80 199 259529 37684 79446976
Developmental delay 19.46 9.80 22 259706 1209 79483451
Venoocclusive liver disease 19.44 9.80 7 259721 11764 79472896
Ulcer 19.37 9.80 43 259685 29929 79454731
Bladder cancer 19.33 9.80 21 259707 19505 79465155
Staphylococcal infection 19.30 9.80 111 259617 58184 79426476
Blood sodium decreased 19.25 9.80 179 259549 33076 79451584
Obsessive thoughts 19.22 9.80 21 259707 1111 79483549
Blood phosphorus increased 19.16 9.80 5 259723 10342 79474318
Compulsive shopping 19.09 9.80 18 259710 798 79483862
Gambling disorder 19.07 9.80 28 259700 1998 79482662
Dysphagia 19.05 9.80 527 259201 121609 79363051
Hypomania 19.04 9.80 61 259667 7483 79477177
Antisocial behaviour 19.00 9.80 17 259711 704 79483956
End stage renal disease 18.97 9.80 8 259720 12212 79472448
Sinusitis 18.95 9.80 488 259240 195013 79289647
Brain injury 18.87 9.80 81 259647 11436 79473224
Metastases to liver 18.81 9.80 40 259688 28274 79456386
Polymyalgia rheumatica 18.79 9.80 44 259684 4493 79480167
Head titubation 18.78 9.80 19 259709 919 79483741
Accidental exposure to product by child 18.78 9.80 34 259694 2892 79481768
Bradycardia 18.71 9.80 576 259152 134981 79349679
Troponin increased 18.68 9.80 117 259611 19138 79465522
Forced expiratory volume decreased 18.66 9.80 62 259666 7752 79476908
Aspiration 18.64 9.80 121 259607 20037 79464623
Obsessive-compulsive personality disorder 18.61 9.80 9 259719 126 79484534
Oculogyric crisis 18.56 9.80 34 259694 2918 79481742
Tongue discolouration 18.54 9.80 39 259689 3704 79480956
Blood loss anaemia 18.53 9.80 14 259714 15484 79469176
Amylase increased 18.49 9.80 79 259649 11130 79473530
Brain malformation 18.36 9.80 7 259721 52 79484608
Sexual abuse 18.29 9.80 11 259717 243 79484417
Tic 18.28 9.80 34 259694 2952 79481708
Homicidal ideation 18.28 9.80 37 259691 3420 79481240
Haemorrhage intracranial 18.26 9.80 36 259692 26157 79458503
Choreoathetosis 18.22 9.80 24 259704 1546 79483114
Intellectual disability 18.22 9.80 22 259706 1298 79483362
Congenital inguinal hernia 18.19 9.80 5 259723 10 79484650
Bursitis 18.18 9.80 58 259670 35786 79448874
Pericardial effusion 18.16 9.80 83 259645 46154 79438506
Wound complication 18.10 9.80 46 259682 4947 79479713
Vomiting 18.05 9.80 1896 257832 663932 78820728
Enuresis 18.01 9.80 35 259693 3141 79481519
Therapeutic response unexpected 18.00 9.80 119 259609 19827 79464833
Staphylococcal sepsis 17.99 9.80 13 259715 14713 79469947
Dependence 17.96 9.80 30 259698 2392 79482268
Angina pectoris 17.94 9.80 97 259631 51635 79433025
Mucormycosis 17.93 9.80 3 259725 8466 79476194
Conversion disorder 17.92 9.80 26 259702 1835 79482825
Formication 17.92 9.80 46 259682 4977 79479683
Purpura fulminans 17.87 9.80 10 259718 192 79484468
Cerebral artery thrombosis 17.81 9.80 20 259708 1091 79483569
Haemoptysis 17.81 9.80 108 259620 55891 79428769
Muscle spasms 17.78 9.80 717 259011 174013 79310647
Brain oedema 17.78 9.80 142 259586 25121 79459539
Cardiac failure chronic 17.75 9.80 7 259721 11128 79473532
Hypoxic-ischaemic encephalopathy 17.75 9.80 61 259667 7759 79476901
Conduction disorder 17.67 9.80 36 259692 3343 79481317
Liver function test abnormal 17.67 9.80 130 259598 64345 79420315
Hyperchloraemia 17.67 9.80 20 259708 1101 79483559
Muscle contracture 17.59 9.80 29 259699 2288 79482372
Rhabdomyolysis 17.52 9.80 450 259278 102681 79381979
Flat affect 17.49 9.80 27 259701 2014 79482646
Wrist fracture 17.39 9.80 81 259647 11840 79472820
Cardiac disorder 17.37 9.80 306 259422 65451 79419209
COVID-19 pneumonia 17.35 9.80 43 259685 28806 79455854
Hyperglycaemia 17.33 9.80 146 259582 70189 79414471
Physical abuse 17.26 9.80 6 259722 33 79484627
Heart rate abnormal 17.17 9.80 51 259677 6006 79478654
Neglect of personal appearance 17.11 9.80 9 259719 152 79484508
Substance use 17.04 9.80 18 259710 916 79483744
Infantile spasms 17.02 9.80 11 259717 277 79484383
Hypersexuality 16.96 9.80 24 259704 1656 79483004
Haematoma 16.95 9.80 100 259628 52095 79432565
Breast cancer stage II 16.92 9.80 3 259725 8117 79476543
Gastrointestinal toxicity 16.89 9.80 3 259725 8106 79476554
Hyperbilirubinaemia 16.83 9.80 34 259694 24484 79460176
HIV peripheral neuropathy 16.82 9.80 6 259722 36 79484624
Exposure during pregnancy 16.80 9.80 230 259498 100902 79383758
BK virus infection 16.80 9.80 4 259724 8800 79475860
Colitis microscopic 16.79 9.80 7 259721 10761 79473899
Oedema 16.77 9.80 281 259447 119299 79365361
Excessive eye blinking 16.73 9.80 24 259704 1677 79482983
Blood cholesterol increased 16.71 9.80 183 259545 83537 79401123
Niemann-Pick disease 16.55 9.80 6 259722 38 79484622
Anticonvulsant drug level below therapeutic 16.55 9.80 19 259709 1062 79483598
Nail disorder 16.50 9.80 9 259719 11843 79472817
Decreased appetite 16.38 9.80 930 258798 341488 79143172
Illusion 16.30 9.80 24 259704 1717 79482943
Nephrotic syndrome 16.28 9.80 8 259720 11166 79473494
Hyperammonaemic encephalopathy 16.24 9.80 43 259685 4739 79479921
Myelocyte count increased 16.18 9.80 16 259712 753 79483907
Sudden unexplained death in epilepsy 16.14 9.80 15 259713 653 79484007
Lip and/or oral cavity cancer 16.10 9.80 19 259709 1094 79483566
Social avoidant behaviour 16.06 9.80 43 259685 4771 79479889
Blood uric acid increased 16.06 9.80 12 259716 13348 79471312
Labelled drug-drug interaction medication error 16.03 9.80 42 259686 27608 79457052
Petit mal epilepsy 16.02 9.80 48 259680 5679 79478981
Epstein-Barr virus infection 16.01 9.80 14 259714 14402 79470258
Generalised anxiety disorder 16.01 9.80 27 259701 2170 79482490
Paralysis 16.01 9.80 85 259643 13092 79471568
Staphylococcal bacteraemia 15.98 9.80 10 259718 12208 79472452
Escherichia sepsis 15.97 9.80 4 259724 8504 79476156
Drug ineffective for unapproved indication 15.97 9.80 245 259483 50993 79433667
Injection site pruritus 15.96 9.80 77 259651 42206 79442454
Learning disorder 15.95 9.80 14 259714 565 79484095
Polyarthritis 15.95 9.80 10 259718 12192 79472468
Dysmorphism 15.91 9.80 14 259714 567 79484093
Second primary malignancy 15.86 9.80 14 259714 14336 79470324
Wound infection 15.85 9.80 34 259694 23957 79460703
Allodynia 15.84 9.80 23 259705 1625 79483035
Akinesia 15.82 9.80 34 259694 3278 79481382
Pneumonia bacterial 15.82 9.80 24 259704 19307 79465353
Myelocyte percentage increased 15.75 9.80 10 259718 244 79484416
Abulia 15.74 9.80 18 259710 1002 79483658
Band neutrophil count increased 15.72 9.80 15 259713 675 79483985
Road traffic accident 15.67 9.80 214 259514 43450 79441210
Sinus disorder 15.66 9.80 126 259602 22338 79462322
Poverty of speech 15.64 9.80 14 259714 580 79484080
Facial bones fracture 15.57 9.80 44 259684 5038 79479622
Urosepsis 15.54 9.80 40 259688 26455 79458205
Illness anxiety disorder 15.50 9.80 10 259718 251 79484409
Death 15.31 9.80 2087 257641 564427 78920233
Osteonecrosis 15.29 9.80 51 259677 31044 79453616
Drop attacks 15.25 9.80 18 259710 1037 79483623
Cushingoid 15.24 9.80 6 259722 9546 79475114
Asphyxia 15.21 9.80 77 259651 11643 79473017
Fibrous histiocytoma 15.20 9.80 15 259713 704 79483956
Communication disorder 15.16 9.80 38 259690 4052 79480608
Facet joint syndrome 15.14 9.80 9 259719 11293 79473367
Subarachnoid haemorrhage 15.08 9.80 36 259692 24429 79460231
Hypoalbuminaemia 15.08 9.80 29 259699 21268 79463392
Mouth ulceration 15.03 9.80 69 259659 38325 79446335
Incorrect dose administered 15.02 9.80 341 259387 76289 79408371
Electrocardiogram QRS complex shortened 15.01 9.80 15 259713 715 79483945
Spasmodic dysphonia 14.93 9.80 10 259718 268 79484392
Dermatitis acneiform 14.79 9.80 7 259721 9986 79474674
Peripheral venous disease 14.79 9.80 18 259710 15891 79468769
Abscess 14.77 9.80 33 259695 22918 79461742
Renal hypertension 14.76 9.80 9 259719 204 79484456
Distractibility 14.75 9.80 15 259713 730 79483930
Respiratory dyskinesia 14.74 9.80 6 259722 54 79484606
Sleep talking 14.69 9.80 18 259710 1078 79483582
Intentional product use issue 14.66 9.80 380 259348 151732 79332928
Hepatic cancer 14.65 9.80 8 259720 10521 79474139
Rash erythematous 14.65 9.80 119 259609 57650 79427010
Drug-induced liver injury 14.64 9.80 141 259587 65976 79418684
Pancreatitis acute 14.58 9.80 98 259630 49506 79435154
Tonic convulsion 14.51 9.80 26 259702 2194 79482466
Peroneal nerve palsy 14.48 9.80 48 259680 5994 79478666
Colitis ulcerative 14.47 9.80 61 259667 34681 79449979
Dermatitis exfoliative generalised 14.40 9.80 3 259725 7238 79477422
Feeling cold 14.37 9.80 150 259578 28579 79456081
Erythema multiforme 14.36 9.80 22 259706 17629 79467031
Postictal paralysis 14.27 9.80 11 259717 369 79484291
Organising pneumonia 14.25 9.80 9 259719 10930 79473730
Cystitis haemorrhagic 14.24 9.80 6 259722 9166 79475494
Obstructive airways disorder 14.23 9.80 161 259567 31298 79453362
Autoimmune disorder 14.20 9.80 20 259708 16592 79468068
Lower gastrointestinal haemorrhage 14.20 9.80 19 259709 16106 79468554
Sensorimotor disorder 14.17 9.80 16 259712 878 79483782
Erectile dysfunction 14.16 9.80 89 259639 14575 79470085
Incorrect route of product administration 14.14 9.80 175 259553 34754 79449906
Inappropriate affect 14.13 9.80 21 259707 1515 79483145
Alcohol abuse 14.12 9.80 44 259684 5319 79479341
Antidepressant drug level above therapeutic 14.10 9.80 14 259714 662 79483998
Gastrointestinal hypomotility 14.05 9.80 24 259704 1949 79482711
Hyperarousal 14.02 9.80 5 259723 30 79484630
Heparin-induced thrombocytopenia 14.00 9.80 7 259721 9675 79474985
Choking 13.98 9.80 77 259651 12024 79472636
Cataract 13.96 9.80 132 259596 61988 79422672
Breath holding 13.85 9.80 6 259722 64 79484596
Mental disability 13.85 9.80 6 259722 64 79484596
Lip dry 13.75 9.80 18 259710 15400 79469260
Postmortem blood drug level increased 13.72 9.80 15 259713 794 79483866
Metastases to central nervous system 13.72 9.80 20 259708 16355 79468305
Skin toxicity 13.63 9.80 5 259723 8309 79476351
Autoimmune hepatitis 13.63 9.80 11 259717 11772 79472888
Oral candidiasis 13.63 9.80 50 259678 29578 79455082
Piloerection 13.55 9.80 12 259716 490 79484170
Patient uncooperative 13.46 9.80 14 259714 700 79483960
Respiratory acidosis 13.44 9.80 72 259656 11128 79473532
Dysgraphia 13.44 9.80 36 259692 3996 79480664
Dry skin 13.42 9.80 149 259579 67846 79416814
Locomotive syndrome 13.42 9.80 4 259724 12 79484648
Dysmetria 13.41 9.80 17 259711 1054 79483606
Jealous delusion 13.38 9.80 10 259718 320 79484340
Renal disorder 13.38 9.80 202 259526 41903 79442757
Lymphadenopathy 13.35 9.80 110 259618 53137 79431523
Cyanosis 13.32 9.80 133 259595 25049 79459611
Gout 13.30 9.80 39 259689 24710 79459950
Affective disorder 13.24 9.80 58 259670 8261 79476399
Flank pain 13.21 9.80 28 259700 19816 79464844
Terminal insomnia 13.20 9.80 18 259710 1199 79483461
Blood bicarbonate decreased 13.13 9.80 42 259686 5149 79479511
Increased appetite 13.04 9.80 75 259653 11903 79472757
Enteritis 13.03 9.80 17 259711 14566 79470094
Glossopharyngeal nerve disorder 13.02 9.80 5 259723 38 79484622
Bacterial infection 12.98 9.80 55 259673 31225 79453435
Wound secretion 12.95 9.80 47 259681 6141 79478519
Metabolic syndrome 12.94 9.80 28 259700 2712 79481948
Retinal detachment 12.90 9.80 7 259721 9240 79475420
Pneumothorax 12.89 9.80 48 259680 28275 79456385
Systemic candida 12.89 9.80 3 259725 6703 79477957
Partial seizures with secondary generalisation 12.86 9.80 13 259715 628 79484032
Haematuria traumatic 12.83 9.80 8 259720 189 79484471
Haemorrhage 12.81 9.80 214 259514 90904 79393756
Cluster headache 12.78 9.80 16 259712 980 79483680
Duodenal ulcer 12.75 9.80 21 259707 16348 79468312
Urticaria thermal 12.74 9.80 11 259717 434 79484226
Laryngomalacia 12.74 9.80 4 259724 15 79484645
Uveitis 12.73 9.80 22 259706 16808 79467852
Localised infection 12.73 9.80 71 259657 37504 79447156
Cardiac infection 12.72 9.80 11 259717 435 79484225
Barotrauma 12.72 9.80 8 259720 192 79484468
Drug tolerance 12.70 9.80 59 259669 8616 79476044
Bulbar palsy 12.69 9.80 9 259719 265 79484395
Gastric ulcer 12.65 9.80 62 259666 33843 79450817
Condition aggravated 12.63 9.80 1434 258294 499690 78984970
Antidepressant drug level increased 12.60 9.80 11 259717 441 79484219
Oral pain 12.53 9.80 57 259671 31741 79452919
Drug level increased 12.51 9.80 190 259538 39461 79445199
Full blood count decreased 12.51 9.80 45 259683 26774 79457886
Stoma site irritation 12.49 9.80 9 259719 272 79484388
Escherichia bacteraemia 12.48 9.80 3 259725 6559 79478101
Hyperuricaemia 12.46 9.80 12 259716 11787 79472873
Pulmonary tuberculosis 12.45 9.80 5 259723 7860 79476800
Anticonvulsant drug level increased 12.40 9.80 27 259701 2626 79482034
Deformity 12.38 9.80 8 259720 9597 79475063
Escherichia infection 12.35 9.80 25 259703 17992 79466668
Administration site erythema 12.34 9.80 10 259718 361 79484299
Left ventricular dysfunction 12.33 9.80 28 259700 19333 79465327
Helplessness 12.32 9.80 10 259718 362 79484298
Pneumonia fungal 12.32 9.80 11 259717 11199 79473461
Pupillary reflex impaired 12.27 9.80 31 259697 3322 79481338
Pollakiuria 12.23 9.80 180 259548 37137 79447523
Metabolic acidosis 12.21 9.80 192 259536 82337 79402323
Tenderness 12.17 9.80 38 259690 23604 79461056
Chemical burn of gastrointestinal tract 12.12 9.80 3 259725 3 79484657
Eye movement disorder 12.11 9.80 55 259673 7956 79476704
Petechiae 12.10 9.80 31 259697 20534 79464126
Medication error 12.10 9.80 301 259427 68341 79416319
Grip strength decreased 12.09 9.80 34 259694 21835 79462825
Language disorder 12.06 9.80 30 259698 3184 79481476
Gastrointestinal procedural complication 12.05 9.80 8 259720 211 79484449
Night sweats 12.01 9.80 110 259618 51985 79432675
Breath sounds abnormal 12.00 9.80 21 259707 15963 79468697
Candida infection 11.99 9.80 74 259654 38140 79446520
Sensitivity to weather change 11.98 9.80 55 259673 7992 79476668
Cataplexy 11.98 9.80 15 259713 919 79483741
Acute respiratory failure 11.94 9.80 130 259598 59411 79425249
Immunodeficiency 11.92 9.80 34 259694 21734 79462926
Cerebral atrophy 11.88 9.80 55 259673 8020 79476640
Blepharospasm 11.88 9.80 44 259684 5807 79478853
Therapy interrupted 11.87 9.80 57 259671 31284 79453376
Dissociative disorder 11.85 9.80 14 259714 807 79483853
Trismus 11.85 9.80 42 259686 5425 79479235
Optic nerve operation 11.83 9.80 11 259717 479 79484181
Intensive care unit acquired weakness 11.82 9.80 22 259706 1911 79482749
Vagal nerve stimulator implantation 11.82 9.80 4 259724 20 79484640
Anticonvulsant drug level decreased 11.81 9.80 22 259706 1912 79482748
Blood pressure fluctuation 11.77 9.80 151 259577 66994 79417666
Feeling drunk 11.77 9.80 38 259690 4681 79479979
Cardiac murmur 11.71 9.80 90 259638 15734 79468926
Pulmonary alveolar haemorrhage 11.70 9.80 12 259716 11445 79473215
Tonic clonic movements 11.70 9.80 24 259704 2240 79482420
Taste disorder 11.69 9.80 21 259707 15802 79468858
Device expulsion 11.66 9.80 44 259684 25817 79458843
Congenital knee deformity 11.66 9.80 4 259724 21 79484639
Skin necrosis 11.65 9.80 26 259702 18061 79466599
Anhidrosis 11.63 9.80 8 259720 224 79484436
Polyneuropathy 11.61 9.80 40 259688 24111 79460549
Pulmonary toxicity 11.60 9.80 15 259713 12899 79471761
Hypnopompic hallucination 11.59 9.80 6 259722 98 79484562
Peripheral pulse decreased 11.57 9.80 5 259723 53 79484607
Injection site erythema 11.54 9.80 182 259546 78015 79406645
Scrotal infection 11.52 9.80 12 259716 601 79484059
Medical device site erosion 11.49 9.80 5 259723 54 79484606
Binge eating 11.47 9.80 11 259717 498 79484162
Lip swelling 11.44 9.80 82 259646 40829 79443831
Fear of injection 11.43 9.80 5 259723 7469 79477191
Snoring 11.42 9.80 42 259686 5524 79479136
Metastases to bone 11.38 9.80 41 259687 24386 79460274
Fatigue 11.37 9.80 2771 256957 926956 78557704
Eye pruritus 11.35 9.80 32 259696 20538 79464122
Delusion of replacement 11.35 9.80 7 259721 162 79484498
Abdominal pain lower 11.35 9.80 59 259669 31723 79452937
Focal dyscognitive seizures 11.35 9.80 31 259697 3481 79481179
Vertigo 11.32 9.80 300 259428 68782 79415878
Alcohol poisoning 11.29 9.80 38 259690 4783 79479877
Hypothyroidism 11.18 9.80 236 259492 52156 79432504
Urine oxalate increased 11.12 9.80 8 259720 241 79484419
Sputum discoloured 11.10 9.80 114 259614 21629 79463031
Gastric haemorrhage 11.09 9.80 20 259708 15030 79469630
Tooth injury 11.08 9.80 22 259706 2006 79482654
Product complaint 11.07 9.80 78 259650 13271 79471389
Dissociative identity disorder 11.02 9.80 5 259723 60 79484600
Motor dysfunction 11.02 9.80 84 259644 14649 79470011
Sternal fracture 10.99 9.80 25 259703 2505 79482155
Metastases to lung 10.98 9.80 27 259701 18136 79466524
Colon cancer 10.97 9.80 19 259709 14504 79470156
Abnormal sleep-related event 10.96 9.80 14 259714 875 79483785
Ejaculation disorder 10.94 9.80 11 259717 528 79484132
Decubitus ulcer 10.94 9.80 88 259640 15599 79469061
Asterixis 10.94 9.80 26 259702 2681 79481979
Anal spasm 10.91 9.80 3 259725 6 79484654
Poor feeding infant 10.91 9.80 7 259721 174 79484486
Drug specific antibody present 10.91 9.80 4 259724 6648 79478012
Periorbital swelling 10.83 9.80 27 259701 2869 79481791
Postmortem blood drug level 10.78 9.80 9 259719 339 79484321
Circulatory collapse 10.78 9.80 75 259653 37593 79447067
Homeless 10.78 9.80 6 259722 114 79484546
Vulvovaginal mycotic infection 10.70 9.80 36 259692 4530 79480130
Apnoea 10.67 9.80 70 259658 11634 79473026
Gastrooesophageal reflux disease 10.65 9.80 428 259300 103818 79380842
Faeces soft 10.63 9.80 7 259721 8316 79476344
Infected bite 10.62 9.80 21 259707 1909 79482751
Peritonitis 10.61 9.80 51 259677 27985 79456675
Stoma site pruritus 10.60 9.80 3 259725 7 79484653
Periorbital haemorrhage 10.52 9.80 8 259720 263 79484397
Hepatic function abnormal 10.51 9.80 171 259557 72936 79411724
Panniculitis 10.47 9.80 15 259713 12356 79472304
Device use error 10.47 9.80 5 259723 7096 79477564
Nodal rhythm 10.46 9.80 28 259700 3107 79481553
Myositis 10.45 9.80 30 259698 19138 79465522
Bladder dilatation 10.41 9.80 22 259706 2097 79482563
Antisocial personality disorder 10.40 9.80 5 259723 69 79484591
Pain in jaw 10.40 9.80 98 259630 46053 79438607
Ammonia abnormal 10.34 9.80 7 259721 191 79484469
Cardiac tamponade 10.31 9.80 9 259719 9267 79475393
Rapid eye movements sleep abnormal 10.31 9.80 8 259720 271 79484389
Narcotic bowel syndrome 10.29 9.80 8 259720 272 79484388
Personal relationship issue 10.27 9.80 7 259721 193 79484467
Cytomegalovirus infection reactivation 10.26 9.80 8 259720 8708 79475952
Monocyte percentage increased 10.25 9.80 22 259706 2119 79482541
Pneumatosis intestinalis 10.23 9.80 4 259724 6393 79478267
Injection site swelling 10.23 9.80 101 259627 47031 79437629
Alcoholism 10.23 9.80 31 259697 3692 79480968
Nervous system disorder 10.21 9.80 133 259595 26723 79457937
Hyperphosphataemia 10.18 9.80 4 259724 6372 79478288
Mucosal erosion 10.17 9.80 23 259705 2295 79482365
Neutrophil percentage increased 10.14 9.80 36 259692 4653 79480007
Brain death 10.14 9.80 41 259687 5636 79479024
SARS-CoV-2 test positive 10.12 9.80 14 259714 11702 79472958
Premature labour 10.11 9.80 54 259674 8336 79476324
Cellulitis 10.10 9.80 274 259454 108786 79375874
Sexual dysfunction 10.07 9.80 51 259677 7712 79476948
Therapeutic response decreased 10.07 9.80 155 259573 66698 79417962
Tachycardia 10.04 9.80 690 259038 177078 79307582
Radial nerve palsy 10.03 9.80 10 259718 475 79484185
Initial insomnia 10.02 9.80 47 259681 6891 79477769
Gastric cancer 10.02 9.80 11 259717 10168 79474492
Drug screen false positive 9.97 9.80 15 259713 1094 79483566
Somatic delusion 9.96 9.80 12 259716 706 79483954
Joint effusion 9.96 9.80 28 259700 17986 79466674
Embolism 9.93 9.80 19 259709 13963 79470697
Dementia with Lewy bodies 9.92 9.80 13 259715 833 79483827
Vasculitis 9.89 9.80 45 259683 25057 79459603
Adjustment disorder with depressed mood 9.88 9.80 9 259719 9077 79475583
Impaired self-care 9.87 9.80 25 259703 2682 79481978
Bronchiectasis 9.87 9.80 114 259614 22272 79462388
Diabetes mellitus inadequate control 9.86 9.80 43 259685 24221 79460439
Somatic symptom disorder 9.85 9.80 24 259704 2513 79482147
Decreased activity 9.83 9.80 55 259673 8639 79476021
Blunted affect 9.83 9.80 10 259718 487 79484173
Thrombocytosis 9.81 9.80 8 259720 8518 79476142
Confabulation 9.81 9.80 10 259718 488 79484172
Neuropsychiatric symptoms 9.80 9.80 17 259711 1398 79483262
Gambling 9.80 9.80 8 259720 292 79484368
Pre-existing condition improved 9.80 9.80 40 259688 5523 79479137

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Tricuspid valve incompetence 33.98 29.35 12 321 61 89398

Pharmacologic Action:

SourceCodeDescription
ATC N03AE01 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Benzodiazepine derivatives
FDA CS M0002356 Benzodiazepines
CHEBI has role CHEBI:35474 anti-anxiety agents
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:50268 GABA modulators
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D018377 Neurotransmitter Agents
FDA EPC N0000175694 Benzodiazepine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Myoclonic seizure indication 37356005
Atonic seizure indication 42365007
Absence seizure indication 79631006
Lennox-Gastaut syndrome indication 230418006
Panic disorder indication 371631005 DOID:594
Akathisia off-label use 285145004
Manic Bipolar Disorder Adjunct Treatment off-label use
Suicidal thoughts contraindication 6471006
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Hepatic failure contraindication 59927004
Substance abuse contraindication 66214007
Sleep apnea contraindication 73430006 DOID:0050847
Decreased respiratory function contraindication 80954004
Open-angle glaucoma contraindication 84494001 DOID:1067
Kidney disease contraindication 90708001 DOID:557
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Syncope contraindication 271594007
Pregnancy, function contraindication 289908002
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.65 acidic
pKa2 1.65 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 8.07 WOMBAT-PK CHEMBL
GABA-A receptor; anion channel Ion channel Ki 9.07 CHEMBL
GABA-A receptor; anion channel Ion channel IC50 8.77 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 9.07 CHEMBL

External reference:

IDSource
4017791 VUID
N0000146152 NUI
D00280 KEGG_DRUG
202585 RXNORM
4017791 VANDF
C0009011 UMLSCUI
CHEBI:3756 CHEBI
CHEMBL452 ChEMBL_ID
DB01068 DRUGBANK_ID
D002998 MESH_DESCRIPTOR_UI
2802 PUBCHEM_CID
6963 IUPHAR_LIGAND_ID
2765 INN_ID
5PE9FDE8GB UNII
1345 MMSL
377 MMSL
4477 MMSL
d00197 MMSL
001635 NDDF
387383007 SNOMEDCT_US
69708003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Klonopin HUMAN PRESCRIPTION DRUG LABEL 1 0004-0058 TABLET 1 mg ORAL NDA 30 sections
Klonopin HUMAN PRESCRIPTION DRUG LABEL 1 0004-0058 TABLET 1 mg ORAL NDA 30 sections
Klonopin HUMAN PRESCRIPTION DRUG LABEL 1 0004-0068 TABLET 0.50 mg ORAL NDA 30 sections
Klonopin HUMAN PRESCRIPTION DRUG LABEL 1 0004-0068 TABLET 0.50 mg ORAL NDA 30 sections
Klonopin HUMAN PRESCRIPTION DRUG LABEL 1 0004-0098 TABLET 2 mg ORAL NDA 30 sections
Klonopin HUMAN PRESCRIPTION DRUG LABEL 1 0004-0098 TABLET 2 mg ORAL NDA 30 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-0832 TABLET 0.50 mg ORAL ANDA 20 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-0832 TABLET 0.50 mg ORAL ANDA 20 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-0832 TABLET 0.50 mg ORAL ANDA 20 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3212 TABLET 1 mg ORAL ANDA 20 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3212 TABLET 1 mg ORAL ANDA 20 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3212 TABLET 1 mg ORAL ANDA 20 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3213 TABLET 2 mg ORAL ANDA 20 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3213 TABLET 2 mg ORAL ANDA 20 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3213 TABLET 2 mg ORAL ANDA 20 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9290 TABLET, ORALLY DISINTEGRATING 0.13 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9290 TABLET, ORALLY DISINTEGRATING 0.13 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9290 TABLET, ORALLY DISINTEGRATING 0.13 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9291 TABLET, ORALLY DISINTEGRATING 0.25 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9291 TABLET, ORALLY DISINTEGRATING 0.25 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9291 TABLET, ORALLY DISINTEGRATING 0.25 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9292 TABLET, ORALLY DISINTEGRATING 0.50 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9292 TABLET, ORALLY DISINTEGRATING 0.50 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9292 TABLET, ORALLY DISINTEGRATING 0.50 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9293 TABLET, ORALLY DISINTEGRATING 1 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9293 TABLET, ORALLY DISINTEGRATING 1 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9293 TABLET, ORALLY DISINTEGRATING 1 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9293 TABLET, ORALLY DISINTEGRATING 1 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9294 TABLET, ORALLY DISINTEGRATING 2 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9294 TABLET, ORALLY DISINTEGRATING 2 mg ORAL ANDA 27 sections