clonazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 703 1622-61-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clonazepam
  • lonazep
  • klonopin
An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
  • Molecular weight: 315.71
  • Formula: C15H10ClN3O3
  • CLOGP: 2.38
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 87.28
  • ALOGS: -4.47
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
8 mg O
8 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.42 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.90 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.88 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.15 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 38 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.273 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.552 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 81.658 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 9.594 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 17.480 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 28.100 % High 1
herg hERG pIC50 4.717 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 2.280 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 4.446 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 16.960 % High 1
kinase-safety-class ACVR2B,EIF2AK3,GRK2,MAPK10,MAPK7,PDK1,PDK2,PDK4 8
kinase-selectivity-class AXL,GRK2,PDK4,TTK 4
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.667 High 1
mh-clint Mouse hepatocyte intrinsic clearance 6.808 High 1
mppb Mouse plasma protein binding (% unbound) 16.040 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 3.802 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 23.860 % High 1
rh-clint Rat hepatocyte intrinsic clearance 17.179 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 72.770 % High 1
rppb Rat plasma protein binding (% unbound) 16.290 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 24.266 uM High 1

Approvals:

DateAgencyCompanyOrphan
June 4, 1975 FDA ROCHE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3301.50 9.98 2914 245410 142144 90237979
Toxicity to various agents 1353.66 9.98 2647 245677 285199 90094924
Suicide attempt 1063.77 9.98 1168 247156 74231 90305892
Intentional overdose 854.07 9.98 1165 247159 92669 90287454
Drug abuse 844.46 9.98 1084 247240 81263 90298860
Synovitis 820.57 9.98 17 248307 329735 90050388
Somnolence 791.11 9.98 1760 246564 207324 90172799
Systemic lupus erythematosus 719.52 9.98 77 248247 361819 90018304
Hand deformity 704.78 9.98 24 248300 296338 90083785
Contraindicated product administered 702.92 9.98 44 248280 320095 90060028
Suicidal ideation 697.91 9.98 934 247390 72921 90307202
Seizure 684.02 9.98 1377 246947 151252 90228871
Glossodynia 669.94 9.98 57 248267 321722 90058401
Pericarditis 641.91 9.98 22 248302 270129 90109994
Respiratory arrest 573.20 9.98 574 247750 32737 90347386
Cardio-respiratory arrest 571.43 9.98 782 247542 62358 90317765
Helicobacter infection 571.03 9.98 10 248314 226840 90153283
Infusion related reaction 559.74 9.98 221 248103 416559 89963564
Arthropathy 520.78 9.98 177 248147 366065 90014058
Sopor 513.65 9.98 472 247852 24172 90355951
Wound 511.20 9.98 104 248220 302876 90077247
Schizophrenia 497.34 9.98 375 247949 14539 90365584
Psychotic disorder 482.75 9.98 508 247816 30722 90349401
Folliculitis 480.65 9.98 18 248306 204335 90175788
Drug intolerance 471.45 9.98 325 247999 447266 89932857
Drug withdrawal syndrome 452.51 9.98 472 247852 28251 90351872
Joint swelling 438.19 9.98 440 247884 502860 89877263
Rheumatoid factor positive 434.31 9.98 7 248317 171643 90208480
Muscle injury 431.86 9.98 11 248313 176643 90203480
Dissociation 410.39 9.98 246 248078 6469 90373654
Tremor 407.93 9.98 1128 247196 152045 90228078
Rheumatic fever 402.08 9.98 3 248321 153118 90227005
Swelling 394.54 9.98 341 247983 418717 89961406
Impaired healing 387.54 9.98 84 248240 234115 90146008
Alopecia 373.18 9.98 486 247838 494585 89885538
Cardiac arrest 364.95 9.98 855 247469 104080 90276043
Abdominal discomfort 358.29 9.98 470 247854 476858 89903265
Stomatitis 356.65 9.98 153 248171 274545 90105578
Overdose 352.41 9.98 1091 247233 156618 90223505
Hypersensitivity 352.34 9.98 437 247887 454240 89925883
Depression 351.28 9.98 1692 246632 298909 90081214
Nasal oedema 350.85 9.98 221 248103 6363 90373760
Treatment failure 344.03 9.98 203 248121 303725 90076398
General physical health deterioration 336.57 9.98 287 248037 354828 90025295
Rheumatoid arthritis 334.09 9.98 301 248023 362313 90017810
Irritable bowel syndrome 316.71 9.98 88 248236 207360 90172763
Agitation 315.47 9.98 618 247706 66480 90313643
Irritability 312.53 9.98 435 247889 35227 90344896
Rash 308.37 9.98 1133 247191 794967 89585156
Anxiety 303.59 9.98 1660 246664 308112 90072011
Drug dependence 303.47 9.98 388 247936 28939 90351184
Stubbornness 296.48 9.98 88 248236 324 90379799
Panic attack 289.00 9.98 359 247965 26006 90354117
Maternal exposure during pregnancy 286.29 9.98 339 247985 359724 90020399
Sedation 286.29 9.98 491 247833 47680 90332443
Liver injury 284.53 9.98 60 248264 170507 90209616
Psoriatic arthropathy 273.54 9.98 142 248182 228193 90151930
Infection 272.09 9.98 356 247968 361738 90018385
Discomfort 271.94 9.98 212 248112 274123 90106000
Hepatic enzyme increased 263.60 9.98 362 247962 360374 90019749
Intentional self-injury 255.83 9.98 357 247967 28977 90351146
Abnormal behaviour 254.27 9.98 312 248012 22316 90357807
Serotonin syndrome 253.06 9.98 407 247917 37480 90342643
Depressed level of consciousness 250.77 9.98 591 247733 72193 90307930
Lower respiratory tract infection 250.59 9.98 192 248132 250467 90129656
Withdrawal syndrome 245.75 9.98 306 248018 22218 90357905
Ill-defined disorder 243.06 9.98 101 248223 184790 90195333
Therapeutic product effect decreased 240.83 9.98 243 248081 277328 90102795
Drug interaction 240.26 9.98 1435 246889 275018 90105105
Asthma 240.02 9.98 1302 247022 240858 90139265
Facet joint syndrome 233.59 9.98 8 248316 98381 90281742
Rhinitis allergic 227.85 9.98 255 248069 16530 90363593
Gastrointestinal disorder 226.96 9.98 221 248103 256466 90123657
Sleep disorder due to general medical condition, insomnia type 221.45 9.98 42 248282 128652 90251471
Unresponsive to stimuli 219.24 9.98 383 247941 37738 90342385
Poisoning 216.60 9.98 237 248087 14980 90365143
Dyskinesia 216.57 9.98 372 247952 36162 90343961
Aggression 215.53 9.98 313 248011 26355 90353768
Mobility decreased 213.54 9.98 223 248101 250511 90129612
Blister 212.47 9.98 231 248093 254767 90125356
Lip dry 212.34 9.98 17 248307 100938 90279185
Joint range of motion decreased 206.13 9.98 58 248266 135585 90244538
Neuroleptic malignant syndrome 204.33 9.98 229 248095 14867 90365256
Sensitisation 202.30 9.98 132 248192 4043 90376080
Polycystic ovaries 199.29 9.98 147 248177 5507 90374616
Tardive dyskinesia 198.47 9.98 194 248130 10736 90369387
Wound infection 195.75 9.98 29 248295 106373 90273750
Bursitis 195.09 9.98 59 248265 131595 90248528
Type 2 diabetes mellitus 192.71 9.98 164 248160 203080 90177043
Mental disorder 190.16 9.98 328 247996 31990 90348133
Feeling abnormal 189.08 9.98 933 247391 166302 90213821
Thinking abnormal 188.73 9.98 195 248129 11537 90368586
Balance disorder 187.30 9.98 639 247685 96441 90283682
Speech disorder 187.14 9.98 397 247927 45188 90334935
Crying 185.81 9.98 286 248038 25359 90354764
Pulmonary fibrosis 183.03 9.98 36 248288 107467 90272656
Peripheral venous disease 179.69 9.98 13 248311 83908 90296215
Mania 177.20 9.98 206 248118 13918 90366205
Anger 176.98 9.98 203 248121 13517 90366606
Respiratory tract infection 176.25 9.98 454 247870 58624 90321499
Loss of consciousness 168.32 9.98 796 247528 139442 90240681
Ejection fraction 167.82 9.98 104 248220 2907 90377216
Dystonia 166.92 9.98 218 248106 16601 90363522
Mood altered 166.72 9.98 220 248104 16924 90363199
Jaundice cholestatic 165.30 9.98 169 248155 9874 90370249
Hyperhidrosis 164.56 9.98 775 247549 135530 90244593
Disturbance in attention 160.59 9.98 381 247943 46728 90333395
Nervousness 159.21 9.98 313 248011 33743 90346380
Hypercholesterolaemia 157.31 9.98 41 248283 100851 90279272
Cholelithiasis 157.14 9.98 404 247920 52102 90328021
Nightmare 157.00 9.98 242 248082 21483 90358640
Blood cholesterol increased 155.60 9.98 205 248119 207807 90172316
Dysarthria 151.63 9.98 408 247916 54074 90326049
Nasopharyngitis 149.62 9.98 591 247733 406513 89973610
Hallucination 146.91 9.98 456 247868 65503 90314620
Arthralgia 146.80 9.98 1395 246929 777127 89602996
Live birth 142.24 9.98 23 248301 79084 90301039
Ataxia 141.80 9.98 209 248115 17833 90362290
Multiple-drug resistance 141.15 9.98 138 248186 7638 90372485
Restless legs syndrome 140.06 9.98 234 248090 22236 90357887
Coma 139.14 9.98 477 247847 72155 90307968
Inflammation 138.76 9.98 171 248153 178421 90201702
Restlessness 138.50 9.98 304 248020 35416 90344707
C-reactive protein increased 137.47 9.98 177 248147 181212 90198911
Mydriasis 137.35 9.98 187 248137 14825 90365298
Multiple sclerosis 136.40 9.98 261 248063 27579 90352544
Product use issue 136.34 9.98 456 247868 329463 90050660
Lung disorder 135.97 9.98 126 248198 149757 90230366
Nasal polyps 133.68 9.98 157 248167 10723 90369400
Musculoskeletal pain 130.93 9.98 166 248158 171085 90209038
Acute kidney injury 130.90 9.98 445 247879 319942 90060181
Paranoia 130.74 9.98 169 248155 12739 90367384
Injury 130.45 9.98 212 248112 197137 90182986
Peripheral swelling 127.48 9.98 640 247684 412466 89967657
Autoimmune disorder 125.89 9.98 28 248296 76716 90303407
Sleep apnoea syndrome 125.15 9.98 272 248052 31475 90348648
Myelosuppression 121.70 9.98 6 248318 53585 90326538
Drooling 118.69 9.98 99 248225 4447 90375676
Febrile neutropenia 118.46 9.98 156 248168 158193 90221930
Adjustment disorder with depressed mood 118.11 9.98 10 248314 56743 90323380
Myoglobin urine present 117.28 9.98 52 248272 710 90379413
Hip arthroplasty 116.85 9.98 32 248292 76176 90303947
Fall 116.69 9.98 1911 246413 479899 89900224
Asthma-chronic obstructive pulmonary disease overlap syndrome 116.27 9.98 101 248223 4798 90375325
Grip strength decreased 116.20 9.98 54 248270 92522 90287601
Mood swings 115.16 9.98 205 248119 20497 90359626
Urinary tract discomfort 114.45 9.98 54 248270 858 90379265
Thrombocytopenia 114.41 9.98 251 248073 208474 90171649
Muscle rigidity 114.25 9.98 167 248157 14142 90365981
Intentional product misuse 113.66 9.98 517 247807 89087 90291036
Lower limb fracture 112.39 9.98 46 248278 84967 90295156
Oedema 112.27 9.98 935 247389 199360 90180763
Feeling of despair 112.25 9.98 83 248241 3121 90377002
Multiple sclerosis relapse 112.24 9.98 357 247967 51948 90328175
Bone erosion 111.28 9.98 9 248315 53012 90327111
Nail disorder 111.21 9.98 15 248309 59052 90321071
Musculoskeletal stiffness 111.10 9.98 427 247897 296105 90084018
Liver function test increased 110.43 9.98 47 248277 84808 90295315
Hypersomnia 109.38 9.98 205 248119 21326 90358797
Disorientation 107.67 9.98 315 248009 43799 90336324
Cogwheel rigidity 105.64 9.98 68 248256 2034 90378089
Sciatica 104.67 9.98 75 248249 101307 90278816
Gastric pH decreased 104.49 9.98 52 248272 934 90379189
Substance abuse 103.89 9.98 99 248225 5307 90374816
Knee arthroplasty 103.66 9.98 49 248275 83133 90296990
Lethargy 102.56 9.98 393 247931 62746 90317377
Total lung capacity increased 102.34 9.98 95 248229 4926 90375197
Insomnia 101.91 9.98 1377 246947 332097 90048026
Hallucination, auditory 101.76 9.98 168 248156 15807 90364316
Alveolar osteitis 101.41 9.98 54 248270 1123 90379000
Lupus-like syndrome 100.58 9.98 9 248315 48837 90331286
Emotional disorder 99.98 9.98 161 248163 14836 90365287
Product substitution issue 99.75 9.98 178 248146 17830 90362293
Bradyphrenia 98.81 9.98 113 248211 7499 90372624
Pneumonia 98.62 9.98 2365 245959 635694 89744429
Head injury 98.56 9.98 245 248079 30943 90349180
Delusion 98.37 9.98 153 248171 13687 90366436
Tunnel vision 97.98 9.98 60 248264 1641 90378482
Blood test abnormal 97.25 9.98 192 248132 20760 90359363
Drug withdrawal convulsions 97.00 9.98 57 248267 1443 90378680
Vision blurred 96.59 9.98 574 247750 109719 90270404
Intentional product use issue 96.41 9.98 290 248034 216602 90163521
Bipolar disorder 96.30 9.98 121 248203 8864 90371259
Hypokinesia 95.88 9.98 162 248162 15535 90364588
Carpal tunnel syndrome 95.44 9.98 206 248118 23722 90356401
Movement disorder 94.92 9.98 231 248093 28788 90351335
Akathisia 94.60 9.98 134 248190 11025 90369098
Burning sensation 94.23 9.98 384 247940 63068 90317055
Heart rate increased 92.18 9.98 577 247747 112325 90267798
Status epilepticus 90.08 9.98 175 248149 18699 90361424
Hypoaesthesia oral 88.73 9.98 156 248168 15444 90364679
Taste disorder 88.62 9.98 29 248295 61517 90318606
Stress 88.31 9.98 449 247875 80946 90299177
Onychomadesis 88.24 9.98 11 248313 45987 90334136
Night sweats 88.22 9.98 135 248189 128631 90251492
Liver disorder 88.13 9.98 122 248202 121147 90258976
Mental status changes 87.82 9.98 296 248028 44383 90335740
Osteoarthritis 87.49 9.98 261 248063 195469 90184654
Pneumonia aspiration 87.44 9.98 279 248045 40661 90339462
On and off phenomenon 87.13 9.98 65 248259 2478 90377645
Derealisation 87.12 9.98 53 248271 1432 90378691
Obesity 85.15 9.98 98 248226 105409 90274714
Bladder pain 85.05 9.98 66 248258 2671 90377452
Animal scratch 84.15 9.98 56 248268 1774 90378349
Neutropenia 82.83 9.98 326 247998 224578 90155545
Depressed mood 82.71 9.98 314 248010 49908 90330215
Hypertension 81.32 9.98 831 247493 456701 89923422
Respiratory depression 81.25 9.98 150 248174 15425 90364698
Electrocardiogram QT prolonged 80.23 9.98 402 247922 72054 90308069
Off label use 80.22 9.98 2355 245969 1099897 89280226
Breast cancer stage II 80.09 9.98 4 248320 35330 90344793
Bronchiectasis 77.61 9.98 182 248142 22148 90357975
Depersonalisation/derealisation disorder 77.61 9.98 51 248273 1581 90378542
Toxic encephalopathy 77.53 9.98 107 248217 8592 90371531
Disease progression 77.31 9.98 199 248125 156416 90223707
Malignant neoplasm progression 77.17 9.98 108 248216 106762 90273361
Miosis 76.17 9.98 111 248213 9373 90370750
Anaemia 76.09 9.98 610 247714 352192 90027931
Bradykinesia 75.29 9.98 93 248231 6695 90373428
Incontinence 74.67 9.98 133 248191 13302 90366821
C-reactive protein 72.90 9.98 3 248321 31364 90348759
H1N1 influenza 72.51 9.98 53 248271 1957 90378166
Cardiac murmur 71.84 9.98 156 248168 18038 90362085
Post-traumatic stress disorder 71.67 9.98 91 248233 6737 90373386
Gait inability 71.60 9.98 187 248137 146269 90233854
Major depression 71.41 9.98 111 248213 9924 90370199
Wheezing 71.40 9.98 980 247344 237100 90143023
Exposure during pregnancy 71.39 9.98 373 247951 238037 90142086
Nephrectomy 70.94 9.98 52 248272 1929 90378194
Diarrhoea 70.67 9.98 1997 246327 937193 89442930
Urinary retention 70.63 9.98 246 248078 37498 90342625
Urticaria 70.57 9.98 534 247790 312200 90067923
Hepatic cirrhosis 70.41 9.98 43 248281 63210 90316913
Sarcoidosis 70.36 9.98 114 248210 10559 90369564
Red blood cell sedimentation rate increased 69.64 9.98 74 248250 82521 90297602
Exposure via ingestion 69.46 9.98 58 248266 2609 90377514
Parkinsonism 67.84 9.98 131 248193 13934 90366189
Sinusitis 66.90 9.98 609 247715 342479 90037644
Ejection fraction abnormal 66.60 9.98 55 248269 2436 90377687
Drug tolerance decreased 65.94 9.98 6 248318 32124 90347999
Osmolar gap increased 65.62 9.98 23 248301 159 90379964
Blepharospasm 65.57 9.98 35 248289 55410 90324713
Psychomotor hyperactivity 65.09 9.98 122 248202 12691 90367432
Generalised tonic-clonic seizure 64.89 9.98 227 248097 34676 90345447
Influenza like illness 64.56 9.98 410 247914 80201 90299922
Adverse drug reaction 64.20 9.98 140 248184 116561 90263562
Pleurothotonus 64.17 9.98 42 248282 1293 90378830
Suspected suicide 64.17 9.98 103 248221 9465 90370658
Sluggishness 63.47 9.98 80 248244 5879 90374244
Abnormal dreams 63.29 9.98 112 248212 11145 90368978
Blood creatine phosphokinase increased 62.15 9.98 220 248104 33803 90346320
Feeling of body temperature change 62.02 9.98 77 248247 5572 90374551
Emotional distress 61.85 9.98 231 248093 36431 90343692
Drug-induced liver injury 60.61 9.98 96 248228 90222 90289901
Galactorrhoea 60.04 9.98 69 248255 4603 90375520
Gait disturbance 58.82 9.98 1022 247302 259474 90120649
Middle insomnia 58.73 9.98 137 248187 16614 90363509
Electroencephalogram abnormal 58.65 9.98 64 248260 4032 90376091
Drug screen negative 58.04 9.98 25 248299 317 90379806
Therapeutic response unexpected 58.02 9.98 161 248163 21719 90358404
Exostosis 57.93 9.98 37 248287 53097 90327026
Extrapyramidal disorder 57.89 9.98 134 248190 16169 90363954
Abdominal pain upper 57.51 9.98 608 247716 332066 90048057
Dysphagia 57.04 9.98 513 247811 111765 90268358
Onychomycosis 56.72 9.98 16 248308 37360 90342763
Cardiac disorder 56.37 9.98 306 248018 56566 90323557
Hostility 56.25 9.98 48 248276 2225 90377898
Gastrointestinal procedural complication 55.80 9.98 27 248297 455 90379668
Urinary incontinence 55.49 9.98 227 248097 37339 90342784
Pruritus 55.47 9.98 1098 247226 540427 89839696
Altered state of consciousness 55.14 9.98 201 248123 31331 90348792
Ear congestion 54.98 9.98 57 248267 3385 90376738
Atrial fibrillation 54.89 9.98 185 248139 133426 90246697
Cough 54.86 9.98 1361 246963 367601 90012522
Hyperprolactinaemia 54.81 9.98 71 248253 5362 90374761
Hypoventilation 54.67 9.98 70 248254 5226 90374897
Persecutory delusion 54.65 9.98 55 248269 3153 90376970
Prescribed overdose 54.62 9.98 116 248208 97509 90282614
Vomiting 54.59 9.98 2661 245663 785632 89594491
Libido increased 54.07 9.98 42 248282 1702 90378421
Pancytopenia 53.99 9.98 160 248164 120103 90260020
Psychomotor retardation 53.74 9.98 66 248258 4723 90375400
Limb injury 53.54 9.98 199 248125 31309 90348814
Respiratory rate decreased 53.18 9.98 60 248264 3923 90376200
Macular degeneration 52.75 9.98 19 248305 37951 90342172
Granulocytopenia 52.62 9.98 76 248248 6365 90373758
Menstrual disorder 52.46 9.98 74 248250 6064 90374059
Therapy non-responder 52.34 9.98 195 248129 136509 90243614
Fear 51.91 9.98 130 248194 16492 90363631
Paranasal sinus discomfort 51.80 9.98 74 248250 6136 90373987
Interstitial lung disease 51.47 9.98 81 248243 76324 90303799
Disorganised speech 51.19 9.98 42 248282 1843 90378280
Pleural effusion 50.99 9.98 148 248176 111843 90268280
Drug screen positive 50.85 9.98 57 248267 3700 90376423
Sinus pain 50.62 9.98 68 248256 5321 90374802
Mucosal inflammation 50.42 9.98 50 248274 57575 90322548
Hallucinations, mixed 50.34 9.98 71 248253 5818 90374305
Coeliac disease 50.11 9.98 30 248294 44580 90335543
Pyrexia 49.91 9.98 1403 246921 659082 89721041
Muscle disorder 49.74 9.98 68 248256 5411 90374712
Forced expiratory volume decreased 49.61 9.98 70 248254 5738 90374385
Drug use disorder 49.50 9.98 85 248239 8258 90371865
Nystagmus 48.74 9.98 78 248246 7149 90372974
Adverse event 48.63 9.98 162 248162 117256 90262867
Renal impairment 48.23 9.98 139 248185 105282 90274841
Atonic seizures 47.56 9.98 29 248295 787 90379336
Hypothyroidism 47.46 9.98 278 248046 52849 90327274
Stoma site discharge 47.19 9.98 41 248283 1948 90378175
Laryngitis 46.80 9.98 42 248282 50711 90329412
Intellectual disability 46.60 9.98 34 248290 1252 90378871
Ulcer haemorrhage 46.54 9.98 8 248316 26313 90353810
Finger deformity 46.49 9.98 16 248308 32881 90347242
Colitis ulcerative 46.47 9.98 58 248266 60208 90319915
Foot deformity 46.42 9.98 57 248267 59594 90320529
Dyspepsia 46.28 9.98 335 247989 197825 90182298
Decompression sickness 46.23 9.98 16 248308 106 90380017
Parosmia 45.91 9.98 75 248249 6994 90373129
Somnambulism 45.87 9.98 70 248254 6158 90373965
Blood urine present 45.68 9.98 127 248197 17151 90362972
Incoherent 45.53 9.98 62 248262 4915 90375208
Salivary hypersecretion 45.47 9.98 86 248238 9006 90371117
Dysphoria 45.09 9.98 69 248255 6085 90374038
Decorticate posture 45.06 9.98 21 248303 324 90379799
Myoclonus 44.98 9.98 135 248189 19033 90361090
Muscle twitching 44.64 9.98 157 248167 24045 90356078
Amylase increased 44.54 9.98 74 248250 6998 90373125
Therapeutic product ineffective 44.11 9.98 43 248281 2371 90377752
Bronchopulmonary aspergillosis allergic 44.05 9.98 53 248271 3713 90376410
Dysuria 43.89 9.98 219 248105 39182 90340941
Myocardial stunning 43.85 9.98 20 248304 293 90379830
Product complaint 43.65 9.98 107 248217 13393 90366730
Aphasia 43.55 9.98 232 248092 42580 90337543
Osteoporosis 42.91 9.98 129 248195 96402 90283721
Substance use disorder 42.69 9.98 39 248285 1981 90378142
Post-traumatic neck syndrome 42.64 9.98 43 248281 2471 90377652
Coma scale abnormal 42.53 9.98 64 248260 5562 90374561
Wound secretion 42.41 9.98 60 248264 4930 90375193
Impaired driving ability 42.21 9.98 61 248263 5112 90375011
Sleep-related eating disorder 42.06 9.98 29 248295 975 90379148
Eosinophilic pleural effusion 41.99 9.98 16 248308 144 90379979
Oromandibular dystonia 41.88 9.98 24 248300 579 90379544
Wound complication 41.57 9.98 58 248266 4705 90375418
Pollakiuria 41.51 9.98 190 248134 32815 90347308
Feeling cold 41.39 9.98 167 248157 27298 90352825
Autonomic nervous system imbalance 41.09 9.98 49 248275 3401 90376722
Broncholithiasis 41.07 9.98 19 248305 288 90379835
Polymyalgia rheumatica 41.06 9.98 59 248265 4918 90375205
Mutism 41.03 9.98 36 248288 1733 90378390
Myocardial depression 40.79 9.98 24 248300 609 90379514
Incorrect dose administered 40.79 9.98 362 247962 78568 90301555
Feeling jittery 40.65 9.98 113 248211 15258 90364865
Blood bilirubin increased 40.48 9.98 230 248094 43240 90336883
Cognitive disorder 40.45 9.98 327 247997 69080 90311043
Rubber sensitivity 40.05 9.98 44 248280 2793 90377330
Panic disorder 40.02 9.98 46 248278 3069 90377054
Neutrophil count decreased 40.01 9.98 85 248239 71447 90308676
Logorrhoea 39.73 9.98 43 248281 2684 90377439
Dopamine dysregulation syndrome 39.66 9.98 16 248308 170 90379953
Sepsis 39.60 9.98 309 248015 179505 90200618
Breast hyperplasia 39.17 9.98 19 248305 322 90379801
Intervertebral disc protrusion 39.12 9.98 163 248161 27033 90353090
Catatonia 38.99 9.98 64 248260 5992 90374131
Tension 38.53 9.98 49 248275 3633 90376490
Mental impairment 38.52 9.98 117 248207 16603 90363520
Suicidal behaviour 38.24 9.98 43 248281 2801 90377322
Malaise 38.19 9.98 1967 246357 584019 89796104
Concussion 38.11 9.98 90 248234 11001 90369122
Obsessive-compulsive disorder 38.05 9.98 54 248270 4450 90375673
Arthritis 38.03 9.98 285 248039 167030 90213093
Soft tissue injury 37.73 9.98 37 248287 2055 90378068
Renal disorder 37.72 9.98 204 248120 37655 90342468
Upper respiratory tract infection 37.69 9.98 202 248122 128116 90252007
Vitamin B12 deficiency 37.68 9.98 71 248253 7415 90372708
Condition aggravated 37.66 9.98 1295 247029 594250 89785873
Blood pressure decreased 37.42 9.98 341 247983 74554 90305569
Secretion discharge 37.35 9.98 112 248212 15784 90364339
Angioedema 37.21 9.98 76 248248 64800 90315323
Paralysis 37.14 9.98 91 248233 11387 90368736
Gastrointestinal haemorrhage 37.04 9.98 125 248199 90123 90290000
Anion gap increased 37.00 9.98 38 248286 2232 90377891
Chronic obstructive pulmonary disease 36.81 9.98 336 247988 73493 90306630
Lymph node calcification 36.75 9.98 19 248305 371 90379752
Toxic epidermal necrolysis 36.37 9.98 181 248143 32347 90347776
Adverse reaction 36.26 9.98 18 248306 29694 90350429
Blood sodium decreased 36.25 9.98 161 248163 27452 90352671
Hypothermia 35.90 9.98 109 248215 15466 90364657
Encephalopathy 35.81 9.98 234 248090 46210 90333913
Walking aid user 35.69 9.98 27 248297 35479 90344644
Tinnitus 35.61 9.98 221 248103 42881 90337242
Coma blister 35.54 9.98 14 248310 139 90379984
Vertigo 35.46 9.98 319 248005 69492 90310631
Hepatotoxicity 35.37 9.98 231 248093 45611 90334512
Bruxism 34.94 9.98 51 248273 4312 90375811
Alcohol abuse 34.90 9.98 35 248289 1998 90378125
Joint stiffness 34.90 9.98 104 248220 77938 90302185
Oropharyngeal oedema 34.89 9.98 18 248306 350 90379773
Hyperammonaemia 34.58 9.98 63 248261 6412 90373711
Hypercalcaemia 34.46 9.98 26 248298 34214 90345909
Drug ineffective 34.45 9.98 3297 245027 1381001 88999122
Blood iron decreased 34.42 9.98 118 248206 17841 90362282
Palmar-plantar erythrodysaesthesia syndrome 34.16 9.98 17 248307 28006 90352117
Apathy 34.11 9.98 86 248238 10954 90369169
Self-injurious ideation 34.11 9.98 43 248281 3160 90376963
Dysgraphia 33.87 9.98 46 248278 3637 90376486
Temperature intolerance 33.37 9.98 90 248234 11940 90368183
Cerebral salt-wasting syndrome 33.05 9.98 15 248309 217 90379906
Melaena 33.05 9.98 28 248296 34769 90345354
Rash pruritic 32.97 9.98 115 248209 82099 90298024
Stoma site hypergranulation 32.93 9.98 18 248306 395 90379728
Sinus tachycardia 32.84 9.98 160 248164 28353 90351770
Piloerection 32.72 9.98 21 248303 625 90379498
Drug detoxification 32.65 9.98 17 248307 337 90379786
Increased appetite 32.62 9.98 88 248236 11677 90368446
Freezing phenomenon 32.59 9.98 32 248292 1780 90378343
Anticonvulsant drug level above therapeutic 32.59 9.98 20 248304 549 90379574
Calculus urinary 32.45 9.98 31 248293 1667 90378456
Choking 32.36 9.98 89 248235 11944 90368179
Coordination abnormal 32.30 9.98 130 248194 21226 90358897
Epidermal necrosis 32.26 9.98 36 248288 2325 90377798
Dependence 32.22 9.98 34 248290 2061 90378062
Mitochondrial toxicity 32.22 9.98 21 248303 642 90379481
Attention deficit hyperactivity disorder 32.20 9.98 48 248276 4136 90375987
Hereditary angioedema 32.19 9.98 76 248248 9289 90370834
Enuresis 31.95 9.98 43 248281 3371 90376752
Cyanosis 31.50 9.98 121 248203 19334 90360789
Hypocalcaemia 31.40 9.98 42 248282 42326 90337797
Dysstasia 31.34 9.98 144 248180 24908 90355215
Formication 31.34 9.98 51 248273 4740 90375383
Fibromyalgia 31.30 9.98 388 247936 205881 90174242
Skin ulcer 31.04 9.98 56 248268 50019 90330104
Hyperkalaemia 30.94 9.98 84 248240 64880 90315243
Cerebellar atrophy 30.76 9.98 22 248302 785 90379338
Euphoric mood 30.64 9.98 54 248270 5355 90374768
Panic reaction 30.57 9.98 50 248274 4667 90375456
Ketosis-prone diabetes mellitus 30.48 9.98 8 248316 16 90380107
Food craving 30.39 9.98 32 248292 1935 90378188
Dry mouth 30.33 9.98 340 247984 183719 90196404
Wrist fracture 30.25 9.98 103 248221 15521 90364602
Cardiac failure 30.18 9.98 176 248148 109320 90270803
Developmental glaucoma 30.16 9.98 10 248314 57 90380066
Adjustment disorder with mixed anxiety and depressed mood 30.12 9.98 12 248312 123 90380000
Drug abuser 30.07 9.98 37 248287 2653 90377470
Antipsychotic drug level increased 30.01 9.98 44 248280 3735 90376388
Sputum discoloured 29.94 9.98 123 248201 20268 90359855
Behaviour disorder 29.86 9.98 49 248275 4586 90375537
Troponin increased 29.73 9.98 92 248232 13189 90366934
Cytomegalovirus infection 29.72 9.98 18 248306 26584 90353539
Septic shock 29.69 9.98 124 248200 84036 90296087
Change in seizure presentation 29.38 9.98 19 248305 573 90379550
Cytopenia 29.36 9.98 6 248318 17443 90362680
Accidental death 29.32 9.98 32 248292 2016 90378107
Bone marrow failure 29.31 9.98 27 248297 32194 90347929
Initial insomnia 29.27 9.98 73 248251 9237 90370886
Anhedonia 29.21 9.98 83 248241 11348 90368775
Neoplasm progression 29.17 9.98 48 248276 44438 90335685
Dizziness 29.17 9.98 1930 246394 587354 89792769
Blood osmolarity increased 29.16 9.98 16 248308 354 90379769
Tenosynovitis 29.15 9.98 3 248321 14564 90365559
Hypoacusis 29.06 9.98 152 248172 27698 90352425
Lactic acidosis 29.03 9.98 59 248265 50404 90329719
Tearfulness 28.75 9.98 49 248275 4731 90375392
Poor quality sleep 28.75 9.98 139 248185 24554 90355569
Myopathy 28.75 9.98 92 248232 13426 90366697
Affective disorder 28.72 9.98 65 248259 7728 90372395
Urinary bladder rupture 28.65 9.98 13 248311 188 90379935
Tachyphrenia 28.61 9.98 29 248295 1677 90378446
Inappropriate schedule of product administration 28.53 9.98 573 247751 149360 90230763
Hyperreflexia 28.50 9.98 59 248265 6598 90373525
Hepatitis 28.33 9.98 99 248225 70640 90309483
Peroneal nerve palsy 28.29 9.98 54 248270 5694 90374429
Back injury 28.13 9.98 53 248271 46569 90333554
Pneumocystis jirovecii pneumonia 28.08 9.98 12 248312 21604 90358519
Amnesia 27.52 9.98 434 247890 108071 90272052
Rhabdomyolysis 27.47 9.98 237 248087 51019 90329104
Illness 27.29 9.98 344 247980 81625 90298498
Bipolar I disorder 27.18 9.98 31 248293 2051 90378072
Hypomania 27.17 9.98 69 248255 8828 90371295
Creatinine renal clearance decreased 27.04 9.98 9 248315 18890 90361233
Product use in unapproved indication 26.95 9.98 708 247616 335528 90044595
Obstructive airways disorder 26.86 9.98 141 248183 25728 90354395
Accidental exposure to product by child 26.74 9.98 25 248299 1308 90378815
Colitis 26.61 9.98 100 248224 69842 90310281
Female genital tract fistula 26.47 9.98 8 248316 17860 90362263
Sternal fracture 26.46 9.98 36 248288 2851 90377272
Conversion disorder 26.42 9.98 31 248293 2115 90378008
Hypotonia 26.37 9.98 80 248244 11346 90368777
Stereotypy 26.05 9.98 16 248308 440 90379683
Rib fracture 26.03 9.98 142 248182 26293 90353830
Accidental overdose 25.94 9.98 149 248175 28124 90351999
Weight abnormal 25.93 9.98 29 248295 1878 90378245
Osteonecrosis of jaw 25.82 9.98 42 248282 39061 90341062
Contusion 25.77 9.98 509 247815 250707 90129416
Rash vesicular 25.46 9.98 9 248315 18188 90361935
Maternal exposure timing unspecified 25.42 9.98 15 248309 22468 90357655
Tongue discolouration 25.36 9.98 39 248285 3454 90376669
Hormone level abnormal 25.09 9.98 35 248289 2838 90377285
White blood cells urine positive 24.84 9.98 55 248269 6443 90373680
Nephrolithiasis 24.78 9.98 224 248100 48861 90331262
Impulsive behaviour 24.71 9.98 27 248297 1703 90378420
Post cholecystectomy syndrome 24.70 9.98 20 248304 861 90379262
Screaming 24.64 9.98 40 248284 3710 90376413
Fluid retention 24.59 9.98 141 248183 87950 90292173
Platelet count decreased 24.59 9.98 248 248076 136721 90243402
Pustular psoriasis 24.59 9.98 10 248314 18546 90361577
Immunodeficiency 24.49 9.98 51 248273 43183 90336940
Hyperthermia 24.45 9.98 73 248251 10262 90369861
Weight decreased 24.44 9.98 1274 247050 378636 90001487
Rectal haemorrhage 24.44 9.98 130 248194 82614 90297509
Myoclonic epilepsy 24.31 9.98 26 248298 1601 90378522
Sebaceous gland infection 24.25 9.98 11 248313 159 90379964
Anorgasmia 24.22 9.98 18 248306 682 90379441
Blood prolactin increased 24.18 9.98 39 248285 3598 90376525
Band neutrophil percentage increased 24.14 9.98 12 248312 215 90379908
Libido decreased 24.09 9.98 35 248289 2947 90377176
Haematochezia 24.09 9.98 106 248218 70807 90309316
Hallucination, visual 24.07 9.98 126 248198 22966 90357157
Hyperammonaemic encephalopathy 23.75 9.98 33 248291 2666 90377457
Upper gastrointestinal haemorrhage 23.70 9.98 17 248307 22959 90357164
Essential tremor 23.67 9.98 24 248300 1388 90378735
Neutropenic sepsis 23.65 9.98 10 248314 18120 90362003
Cytokine release syndrome 23.64 9.98 25 248299 27948 90352175
Lung neoplasm 23.52 9.98 55 248269 6680 90373443
Hypotension 23.38 9.98 1103 247221 324294 90055829
Trismus 23.37 9.98 45 248279 4776 90375347
Heart rate abnormal 23.35 9.98 51 248273 5920 90374203
Aspiration 23.31 9.98 95 248229 15598 90364525
Syncope 23.27 9.98 501 247823 132162 90247961
Blood parathyroid hormone decreased 23.24 9.98 3 248321 12213 90367910
Clumsiness 23.13 9.98 32 248292 2575 90377548
Seizure cluster 23.12 9.98 14 248310 375 90379748
Anticonvulsant drug level increased 22.92 9.98 26 248298 1710 90378413
Impulse-control disorder 22.81 9.98 20 248304 962 90379161
Suspiciousness 22.73 9.98 14 248310 387 90379736
Haemoglobin urine 22.72 9.98 10 248314 134 90379989
Psychotic disorder due to a general medical condition 22.69 9.98 12 248312 246 90379877
Blood triglycerides increased 22.62 9.98 86 248238 13675 90366448
Polyarthritis 22.57 9.98 11 248313 18339 90361784
Tic 22.52 9.98 27 248297 1884 90378239
Stoma site erythema 22.52 9.98 24 248300 1472 90378651
Alcohol poisoning 22.51 9.98 27 248297 1885 90378238
Joint dislocation 22.49 9.98 56 248268 44526 90335597
Personality disorder 22.33 9.98 80 248244 12364 90367759
Head titubation 22.08 9.98 22 248302 1246 90378877
Pre-existing condition improved 21.92 9.98 65 248259 9104 90371019
Anticholinergic syndrome 21.88 9.98 32 248292 2711 90377412
Torsade de pointes 21.84 9.98 91 248233 15091 90365032
Cerebral atrophy 21.82 9.98 48 248276 5598 90374525
Abulia 21.82 9.98 17 248307 692 90379431
Myalgia 21.69 9.98 631 247693 174494 90205629
Treatment noncompliance 21.67 9.98 227 248097 51500 90328623
Thrombotic microangiopathy 21.66 9.98 8 248316 15735 90364388
Mediastinitis 21.61 9.98 13 248311 344 90379779
Psychiatric symptom 21.53 9.98 55 248269 7063 90373060
Eye pain 21.50 9.98 200 248124 43968 90336155
Disability 21.49 9.98 50 248274 40695 90339428
Focal dyscognitive seizures 21.29 9.98 34 248290 3110 90377013
Hypertonia 21.27 9.98 45 248279 5110 90375013
Skin laceration 21.20 9.98 133 248191 25902 90354221
Sensitivity to weather change 21.12 9.98 63 248261 8851 90371272
Drug level above therapeutic 20.90 9.98 48 248276 5761 90374362
Chills 20.82 9.98 491 247833 131490 90248633
Rapid eye movement sleep behaviour disorder 20.71 9.98 13 248311 372 90379751
Compulsive shopping 20.60 9.98 17 248307 752 90379371
Tumour lysis syndrome 20.60 9.98 3 248321 11149 90368974
Gangrene 20.51 9.98 5 248319 12871 90367252
PO2 increased 20.39 9.98 18 248306 874 90379249
Neutrophil count increased 20.35 9.98 106 248218 19284 90360839
Vitamin B12 increased 20.22 9.98 25 248299 1801 90378322
Diabetes mellitus 20.22 9.98 269 248055 64606 90315517
Antidepressant drug level above therapeutic 20.17 9.98 14 248310 476 90379647
Influenza 20.14 9.98 512 247812 138752 90241371
Right ventricular failure 20.09 9.98 14 248310 19191 90360932
Sudden unexplained death in epilepsy 20.01 9.98 13 248311 395 90379728
Parkinsonian gait 19.99 9.98 15 248309 577 90379546
Drop attacks 19.98 9.98 16 248308 678 90379445
Anticonvulsant drug level below therapeutic 19.94 9.98 16 248308 680 90379443
Oculogyric crisis 19.89 9.98 29 248295 2450 90377673
Myelocyte percentage increased 19.83 9.98 10 248314 185 90379938
Hyperphagia 19.81 9.98 31 248293 2787 90377336
Weight gain poor 19.79 9.98 20 248304 1152 90378971
Lung neoplasm malignant 19.76 9.98 124 248200 24149 90355974
Infusion site reaction 19.76 9.98 14 248310 19025 90361098
Sexual abuse 19.59 9.98 11 248313 255 90379868
Body temperature increased 19.58 9.98 198 248126 44512 90335611
Leukopenia 19.49 9.98 179 248145 100531 90279592
Urinary tract infection 19.46 9.98 1024 247300 304608 90075515
Monocyte count abnormal 19.43 9.98 11 248313 259 90379864
Hyperkinesia 19.24 9.98 25 248299 1894 90378229
Cholecystitis chronic 19.22 9.98 65 248259 9761 90370362
Acute myeloid leukaemia 19.12 9.98 17 248307 20623 90359500
Social anxiety disorder 19.10 9.98 15 248309 618 90379505
Temperature regulation disorder 19.08 9.98 8 248316 14571 90365552
Generalised anxiety disorder 19.01 9.98 30 248294 2717 90377406
Soliloquy 19 9.98 12 248312 347 90379776
Mitochondrial encephalomyopathy 18.89 9.98 8 248316 97 90380026
Road traffic accident 18.85 9.98 196 248128 107430 90272693
Sensory disturbance 18.84 9.98 88 248236 15325 90364798
Decreased interest 18.80 9.98 39 248285 4368 90375755
Frequent bowel movements 18.80 9.98 86 248238 56849 90323274
Diplopia 18.79 9.98 139 248185 28575 90351548
Illusion 18.53 9.98 20 248304 1244 90378879
Prescribed underdose 18.39 9.98 125 248199 74894 90305229
Developmental delay 18.39 9.98 23 248301 1677 90378446
Stoma site pain 18.33 9.98 21 248303 1396 90378727
Flat affect 18.27 9.98 23 248301 1688 90378435
Oxygen saturation decreased 18.24 9.98 404 247920 107079 90273044
Spondylitis 18.21 9.98 8 248316 14170 90365953
Alcohol use 18.21 9.98 23 248301 1694 90378429
Wrong technique in product usage process 18.04 9.98 286 248038 71285 90308838
Volvulus 18.01 9.98 26 248298 2177 90377946
Device expulsion 17.91 9.98 55 248269 40831 90339292
Hypnopompic hallucination 17.90 9.98 7 248317 68 90380055
Feeling drunk 17.88 9.98 40 248284 4718 90375405
Feelings of worthlessness 17.87 9.98 12 248312 386 90379737
Joint destruction 17.87 9.98 7 248317 13280 90366843
Memory impairment 17.85 9.98 685 247639 196559 90183564
Dysphemia 17.85 9.98 31 248293 3039 90377084
Neuropsychiatric symptoms 17.75 9.98 15 248309 686 90379437
Precocious puberty 17.67 9.98 11 248313 310 90379813
Keratosis follicular 17.62 9.98 5 248319 15 90380108
Asphyxia 17.60 9.98 51 248273 7052 90373071
Areflexia 17.59 9.98 34 248290 3619 90376504
Spinal disorder 17.59 9.98 71 248253 11608 90368515
Homicidal ideation 17.55 9.98 23 248301 1757 90378366
Oral candidiasis 17.52 9.98 45 248279 35410 90344713
Erythema 17.50 9.98 486 247838 228760 90151363
Infantile spasms 17.49 9.98 10 248314 240 90379883
Bradycardia 17.49 9.98 325 247999 83522 90296601
Cortical dysplasia 17.43 9.98 6 248318 39 90380084
Proteinuria 17.35 9.98 23 248301 23268 90356855
Anaphylactic shock 17.32 9.98 38 248286 31579 90348544
Apnoea 17.30 9.98 61 248263 9353 90370770
Fibrous histiocytoma 17.23 9.98 14 248310 606 90379517
Nephrogenic diabetes insipidus 17.21 9.98 17 248307 953 90379170
Plasma cell myeloma 17.13 9.98 56 248268 40772 90339351
Ventricular fibrillation 17.03 9.98 80 248244 13964 90366159
Blood growth hormone increased 16.95 9.98 13 248311 517 90379606
Urticaria thermal 16.88 9.98 13 248311 520 90379603
Electrocardiogram QT shortened 16.86 9.98 9 248315 188 90379935
Abdominal pain 16.70 9.98 900 247424 394821 89985302
Large intestine polyp 16.55 9.98 60 248264 9326 90370797
Temporomandibular joint syndrome 16.50 9.98 35 248289 3982 90376141
Hyperkeratosis 16.45 9.98 49 248275 6879 90373244
Torticollis 16.42 9.98 27 248297 2531 90377592
Encephalitis autoimmune 16.40 9.98 24 248300 2034 90378089
Facial paralysis 16.36 9.98 85 248239 15449 90364674
Narcotic bowel syndrome 16.31 9.98 8 248316 139 90379984
Eye injury 16.21 9.98 5 248319 11015 90369108
Flight of ideas 16.07 9.98 12 248312 458 90379665
Lip and/or oral cavity cancer 16.06 9.98 16 248308 906 90379217
Social (pragmatic) communication disorder 15.96 9.98 5 248319 23 90380100
Micturition urgency 15.90 9.98 67 248257 11166 90368957
Gaze palsy 15.86 9.98 21 248303 1620 90378503
COVID-19 15.86 9.98 347 247977 168496 90211627
Stoma site infection 15.83 9.98 16 248308 922 90379201
Ascites 15.83 9.98 72 248252 47668 90332455
Blood pressure systolic increased 15.80 9.98 236 248088 58109 90322014
Sensory processing disorder 15.79 9.98 5 248319 24 90380099
Drug screen false positive 15.76 9.98 16 248308 927 90379196
Peripheral pulse decreased 15.65 9.98 6 248318 55 90380068
Pulmonary arterial hypertension 15.60 9.98 30 248294 26157 90353966
Hypomagnesaemia 15.50 9.98 48 248276 35540 90344583
Binge eating 15.43 9.98 13 248311 592 90379531
Narcolepsy 15.42 9.98 20 248304 1512 90378611
Granulocyte count increased 15.40 9.98 20 248304 1514 90378609
Central nervous system lesion 15.36 9.98 68 248256 11578 90368545
Basal cell carcinoma 15.28 9.98 44 248280 33345 90346778
Polydipsia 15.27 9.98 35 248289 4196 90375927
Transplant rejection 15.16 9.98 8 248316 12750 90367373
Reduced facial expression 15.13 9.98 26 248298 2527 90377596
Gastrooesophageal reflux disease 15.13 9.98 578 247746 165759 90214364
Tubulointerstitial nephritis 15.12 9.98 29 248295 25314 90354809
Vitamin D deficiency 15.12 9.98 91 248233 17465 90362658
Hypersexuality 15.05 9.98 13 248311 613 90379510
Muscle contractions involuntary 15.02 9.98 28 248296 2900 90377223
Sleep talking 15.01 9.98 17 248307 1116 90379007
White blood cell count decreased 14.97 9.98 346 247978 166763 90213360
Incision site erythema 14.96 9.98 12 248312 510 90379613
Neurological symptom 14.93 9.98 47 248277 6800 90373323
Tonic convulsion 14.92 9.98 21 248303 1717 90378406
Blood immunoglobulin A increased 14.91 9.98 18 248306 1265 90378858
Blood creatinine increased 14.89 9.98 192 248132 101194 90278929
Proctitis 14.83 9.98 12 248312 15247 90364876
Breast cancer stage I 14.83 9.98 4 248320 9620 90370503
Underdose 14.79 9.98 87 248237 53930 90326193
Psychotic symptom 14.74 9.98 24 248300 2232 90377891
Aerophagia 14.73 9.98 5 248319 31 90380092
Medical device site ulcer 14.71 9.98 3 248321 0 90380123
Suspected product quality issue 14.71 9.98 11 248313 421 90379702
Haematotoxicity 14.69 9.98 8 248316 12527 90367596
Barotrauma 14.66 9.98 8 248316 175 90379948
Cast application 14.59 9.98 5 248319 32 90380091
Red blood cells urine 14.56 9.98 12 248312 530 90379593
Neuralgia 14.52 9.98 141 248183 31359 90348764
Blood potassium increased 14.48 9.98 102 248222 20647 90359476
Solar lentigo 14.45 9.98 17 248307 1163 90378960
Administration site erythema 14.42 9.98 15 248309 894 90379229
Electrocardiogram QRS complex shortened 14.37 9.98 12 248312 540 90379583
Sinus disorder 14.35 9.98 151 248173 34296 90345827
Social avoidant behaviour 14.32 9.98 30 248294 3383 90376740
Feeling guilty 14.32 9.98 13 248311 655 90379468
Haemangioma congenital 14.29 9.98 12 248312 544 90379579
Distractibility 14.23 9.98 12 248312 547 90379576
Partial seizures 14.18 9.98 48 248276 7212 90372911
Psychomotor skills impaired 14.16 9.98 27 248297 2845 90377278
Near death experience 14.08 9.98 14 248310 791 90379332
Myositis 14.06 9.98 28 248296 24100 90356023
Migraine 14.01 9.98 647 247677 189745 90190378
Hypoaesthesia 13.93 9.98 711 247613 313499 90066624
Affect lability 13.92 9.98 91 248233 17972 90362151
Nasal disorder 13.89 9.98 29 248295 3263 90376860
Magnetic resonance imaging abnormal 13.89 9.98 30 248294 3456 90376667
Family stress 13.88 9.98 13 248311 682 90379441
Parkinson's disease 13.84 9.98 16 248308 1074 90379049
Electrocardiogram QRS complex prolonged 13.84 9.98 48 248276 7300 90372823
Patient uncooperative 13.81 9.98 9 248315 275 90379848
Soft tissue haemorrhage 13.81 9.98 9 248315 275 90379848
Skin infection 13.77 9.98 90 248234 17774 90362349
Onychophagia 13.66 9.98 6 248318 80 90380043
Gambling disorder 13.64 9.98 17 248307 1235 90378888
Electric shock 13.60 9.98 20 248304 1702 90378421
Skin discolouration 13.50 9.98 183 248141 44132 90335991
Aplastic anaemia 13.45 9.98 10 248314 13259 90366864
Burning mouth syndrome 13.45 9.98 12 248312 591 90379532
Back pain 13.44 9.98 1026 247298 316149 90063974
Muscle spasms 13.34 9.98 830 247494 251053 90129070
Right ventricular systolic pressure decreased 13.32 9.98 5 248319 43 90380080
Toxicologic test abnormal 13.30 9.98 13 248311 719 90379404
Sensory loss 13.29 9.98 90 248234 17985 90362138
Automatism 13.27 9.98 6 248318 86 90380037
Homeless 13.27 9.98 6 248318 86 90380037
Fractured coccyx 13.27 9.98 17 248307 1270 90378853
Pathogen resistance 13.23 9.98 3 248321 8112 90372011
Eosinophil count abnormal 13.22 9.98 14 248310 852 90379271
Incision site haemorrhage 13.19 9.98 12 248312 606 90379517
Metastases to liver 13.16 9.98 38 248286 28769 90351354
Cushingoid 13.14 9.98 6 248318 10389 90369734
Aspartate aminotransferase 13.11 9.98 13 248311 732 90379391
Pupil fixed 13.05 9.98 22 248302 2106 90378017
Acute generalised exanthematous pustulosis 13.04 9.98 11 248313 13692 90366431
Clinodactyly 13.04 9.98 7 248317 148 90379975
Band neutrophil count increased 13.01 9.98 10 248314 399 90379724
Throat clearing 12.98 9.98 31 248293 3816 90376307
Thyroid atrophy 12.94 9.98 9 248315 307 90379816
Product administration interrupted 12.91 9.98 68 248256 12424 90367699
Bronchitis 12.87 9.98 527 247797 152400 90227723
Breast cancer 12.87 9.98 213 248111 53548 90326575
Pseudolymphoma 12.83 9.98 12 248312 628 90379495
Neurogenic bladder 12.80 9.98 30 248294 3648 90376475
Laboratory test abnormal 12.78 9.98 65 248259 41789 90338334
Metastases to lung 12.74 9.98 15 248309 15976 90364147
Heat stroke 12.73 9.98 14 248310 890 90379233
Shock haemorrhagic 12.71 9.98 9 248315 12236 90367887
Jaundice 12.69 9.98 46 248278 32471 90347652
Intrusive thoughts 12.69 9.98 10 248314 414 90379709
Pulmonary congestion 12.68 9.98 94 248230 19339 90360784
Fever neonatal 12.67 9.98 4 248320 19 90380104
Ear infection 12.66 9.98 126 248198 69649 90310474
Hysterectomy 12.63 9.98 64 248260 11520 90368603
Psychological trauma 12.60 9.98 17 248307 1336 90378787
Urine oxalate increased 12.59 9.98 8 248316 234 90379889
Mitral valve thickening 12.57 9.98 5 248319 51 90380072
Psychogenic seizure 12.57 9.98 21 248303 1995 90378128
Aspergillus infection 12.55 9.98 7 248317 10816 90369307
Disseminated intravascular coagulation 12.54 9.98 25 248299 21513 90358610
Cataplexy 12.51 9.98 18 248306 1502 90378621
Metastases to central nervous system 12.39 9.98 18 248306 17524 90362599
Bipolar II disorder 12.36 9.98 10 248314 430 90379693
Hypervolaemia 12.35 9.98 47 248277 32710 90347413
Congenital muscle absence 12.34 9.98 4 248320 21 90380102
Bronchopulmonary aspergillosis 12.34 9.98 8 248316 11390 90368733
Urticaria chronic 12.32 9.98 13 248311 788 90379335
Hyperbilirubinaemia 12.30 9.98 12 248312 13924 90366199
Full blood count decreased 12.26 9.98 41 248283 29648 90350475
Ischaemic hepatitis 12.25 9.98 25 248299 2768 90377355
Productive cough 12.24 9.98 287 248037 76776 90303347
Glomerular filtration rate increased 12.24 9.98 21 248303 2039 90378084
Tonic clonic movements 12.19 9.98 19 248305 1703 90378420
Bradycardia neonatal 12.16 9.98 15 248309 1078 90379045
Chronic papillomatous dermatitis 12.16 9.98 5 248319 56 90380067
Anticonvulsant drug level decreased 12.15 9.98 17 248307 1383 90378740
Hyperacusis 12.14 9.98 25 248299 2786 90377337
Panniculitis 12.13 9.98 13 248311 14445 90365678
Eyelid injury 12.10 9.98 7 248317 172 90379951
Somatic symptom disorder of pregnancy 12.10 9.98 6 248318 107 90380016
Brain death 12.09 9.98 31 248293 3990 90376133
Death 12.04 9.98 1428 246896 455123 89925000
Subarachnoid haemorrhage 12.04 9.98 19 248305 17885 90362238
Hypoxic-ischaemic encephalopathy 12.03 9.98 34 248290 4634 90375489
Language disorder 11.94 9.98 24 248300 2628 90377495
Gallbladder disorder 11.92 9.98 94 248230 19709 90360414
Circadian rhythm sleep disorder 11.88 9.98 12 248312 691 90379432
Tachycardia 11.85 9.98 537 247787 157136 90222987
Psychiatric decompensation 11.80 9.98 20 248304 1923 90378200
Orthostatic tremor 11.78 9.98 3 248321 5 90380118
Brugada syndrome 11.69 9.98 10 248314 465 90379658
Pancreatolithiasis 11.55 9.98 8 248316 271 90379852
Adjustment disorder 11.53 9.98 6 248318 9636 90370487
Cardiac infection 11.51 9.98 11 248313 592 90379531
Obsessive thoughts 11.43 9.98 11 248313 597 90379526
General symptom 11.43 9.98 14 248310 14654 90365469
Oculocephalogyric reflex absent 11.43 9.98 3 248321 6 90380117
Hypertransaminasaemia 11.41 9.98 16 248308 15809 90364314
Device difficult to use 11.41 9.98 19 248305 17506 90362617
Violence-related symptom 11.38 9.98 11 248313 600 90379523
Stupor 11.38 9.98 37 248287 5445 90374678
Skin necrosis 11.37 9.98 18 248306 16923 90363200
Neuropathy peripheral 11.33 9.98 287 248037 136683 90243440
Pregnancy 11.27 9.98 112 248212 61935 90318188
Lymphocyte count abnormal 11.25 9.98 13 248311 872 90379251
Physical assault 11.24 9.98 13 248311 873 90379250
Diverticulitis 11.22 9.98 75 248249 45112 90335011
Fine motor delay 11.22 9.98 7 248317 198 90379925
Clonus 11.21 9.98 38 248286 5712 90374411
Pancreatic disorder 11.19 9.98 25 248299 2946 90377177
Monocyte count increased 11.17 9.98 52 248272 9045 90371078
Infrequent bowel movements 11.13 9.98 17 248307 1497 90378626
Bone density decreased 11.11 9.98 19 248305 17326 90362797
Congenital knee deformity 11.10 9.98 5 248319 71 90380052
Neutrophil percentage increased 11.01 9.98 25 248299 2978 90377145
Snoring 11.00 9.98 35 248289 5091 90375032
Oropharyngeal spasm 10.98 9.98 8 248316 294 90379829
Monocyte percentage increased 10.98 9.98 15 248309 1193 90378930
Neck injury 10.94 9.98 22 248302 2410 90377713
Decreased activity 10.93 9.98 48 248276 8144 90371979
Anxiety disorder 10.93 9.98 34 248290 4888 90375235
Drug dependence, antepartum 10.92 9.98 5 248319 74 90380049
Pulmonary hypertension 10.85 9.98 70 248254 42453 90337670
Rash papular 10.84 9.98 94 248230 20261 90359862
Unemployment 10.83 9.98 3 248321 8 90380115
Glucose tolerance impaired 10.82 9.98 47 248277 7938 90372185
Retinal depigmentation 10.81 9.98 8 248316 301 90379822
Pericardial effusion 10.80 9.98 58 248266 36775 90343348
Petit mal epilepsy 10.78 9.98 34 248290 4924 90375199
Therapeutic product effect prolonged 10.78 9.98 9 248315 405 90379718
Tobacco user 10.77 9.98 12 248312 774 90379349
Malocclusion 10.76 9.98 6 248318 137 90379986
Hypoglycaemia 10.75 9.98 259 248065 69589 90310534
Myelodysplastic syndrome 10.74 9.98 26 248298 20877 90359246
Myelocyte count increased 10.74 9.98 9 248315 407 90379716
Lip erosion 10.69 9.98 15 248309 1223 90378900
Infected bite 10.69 9.98 20 248304 2077 90378046
Antinuclear antibody positive 10.68 9.98 6 248318 9235 90370888
Congenital jaw malformation 10.68 9.98 5 248319 78 90380045
Wrong patient received product 10.65 9.98 27 248297 3450 90376673
Deep brain stimulation 10.62 9.98 5 248319 79 90380044
Colitis microscopic 10.57 9.98 9 248315 11150 90368973
Injection site reaction 10.54 9.98 183 248141 91897 90288226
Normal newborn 10.54 9.98 31 248293 23331 90356792
Device colour issue 10.50 9.98 4 248320 36 90380087
Breast discharge 10.50 9.98 15 248309 1244 90378879
Bronchial wall thickening 10.46 9.98 20 248304 2111 90378012
Body height increased 10.46 9.98 5 248319 82 90380041
Parasomnia 10.45 9.98 11 248313 665 90379458
Psychotic behaviour 10.45 9.98 11 248313 665 90379458
Posture abnormal 10.42 9.98 23 248301 2688 90377435
Compartment syndrome 10.41 9.98 24 248300 2888 90377235
Eye movement disorder 10.41 9.98 39 248285 6159 90373964
Muscle neoplasm 10.40 9.98 4 248320 37 90380086
Headache 10.40 9.98 2588 245736 860158 89519965
Subendocardial ischaemia 10.35 9.98 5 248319 84 90380039
Metabolic surgery 10.34 9.98 17 248307 1594 90378529
Pulse pressure abnormal 10.34 9.98 3 248321 10 90380113
Hyposmia 10.31 9.98 13 248311 956 90379167
Gastrointestinal injury 10.30 9.98 12 248312 812 90379311
Muscle atrophy 10.30 9.98 48 248276 8353 90371770
Breast pain 10.28 9.98 56 248268 10362 90369761
Patella fracture 10.26 9.98 22 248302 2521 90377602
Alcoholism 10.24 9.98 18 248306 1782 90378341
Dry eye 10.23 9.98 219 248105 57712 90322411
Gallbladder neoplasm 10.22 9.98 4 248320 39 90380084
Eyelid haematoma 10.19 9.98 5 248319 87 90380036
Cholestasis 10.18 9.98 58 248266 36241 90343882
Deformity 10.15 9.98 11 248313 12159 90367964
Pneumonitis 10.14 9.98 75 248249 44095 90336028
Congenital oesophageal anomaly 10.12 9.98 3 248321 11 90380112
Pulmonary toxicity 10.09 9.98 10 248314 11521 90368602
Hepatic pain 10.08 9.98 27 248297 3568 90376555
Activation syndrome 10.06 9.98 7 248317 239 90379884
Perfume sensitivity 10.03 9.98 13 248311 982 90379141
Breast swelling 10.01 9.98 17 248307 1637 90378486
Vulvovaginal mycotic infection 10.00 9.98 39 248285 6275 90373848

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 1992.75 10.92 2012 130128 102759 42386436
Completed suicide 1128.87 10.92 1441 130699 95024 42394171
Depression 999.50 10.92 1463 130677 109900 42379295
Toxicity to various agents 985.25 10.92 2182 129958 226954 42262241
Somnolence 597.21 10.92 1337 130803 139768 42349427
Drug interaction 571.71 10.92 1971 130169 265028 42224167
Coma 557.33 10.92 756 131384 52798 42436397
Overdose 518.31 10.92 1061 131079 104203 42384992
Drug use disorder 483.72 10.92 335 131805 9998 42479197
Drug dependence 460.91 10.92 508 131632 28586 42460609
Intentional overdose 457.77 10.92 674 131466 50782 42438413
Miosis 451.74 10.92 357 131783 13089 42476106
Suicidal ideation 446.08 10.92 643 131497 47518 42441677
Aggression 439.15 10.92 610 131530 43553 42445642
Sopor 427.44 10.92 343 131797 12859 42476336
Substance use disorder 407.61 10.92 236 131904 5109 42484086
Suicide attempt 388.77 10.92 589 131551 45511 42443684
Psychotic disorder 351.34 10.92 443 131697 28765 42460430
Altered state of consciousness 344.39 10.92 439 131701 28820 42460375
Psychiatric decompensation 336.86 10.92 192 131948 4030 42485165
Neuroleptic malignant syndrome 333.28 10.92 371 131769 21101 42468094
Agitation 326.60 10.92 657 131483 63657 42425538
Substance abuse 317.66 10.92 245 131895 8660 42480535
Anxiety 316.17 10.92 945 131195 117615 42371580
Seizure 313.08 10.92 952 131188 119609 42369586
Sedation 295.50 10.92 416 131724 30059 42459136
Poisoning 292.47 10.92 290 131850 14409 42474786
Cardio-respiratory arrest 289.37 10.92 592 131548 58044 42431151
Respiratory arrest 275.58 10.92 388 131752 28036 42461159
Febrile neutropenia 263.67 10.92 123 132017 185580 42303615
Intentional product misuse 253.96 10.92 580 131560 61320 42427875
Paranoia 252.20 10.92 262 131878 13764 42475431
Abnormal behaviour 248.95 10.92 356 131784 26095 42463100
Depression suicidal 244.03 10.92 142 131998 3103 42486092
Tearfulness 236.65 10.92 143 131997 3357 42485838
Drug withdrawal syndrome 231.27 10.92 309 131831 21240 42467955
Anaemia 227.43 10.92 323 131817 279955 42209240
Intentional self-injury 224.51 10.92 256 131884 14946 42474249
Depressed level of consciousness 221.07 10.92 471 131669 47499 42441696
Psychomotor skills impaired 221.00 10.92 159 131981 5045 42484150
Depressive symptom 219.05 10.92 141 131999 3712 42485483
Status epilepticus 194.83 10.92 241 131899 15337 42473858
Dissociation 194.03 10.92 130 132010 3668 42485527
Mydriasis 193.20 10.92 183 131957 8587 42480608
Dyspnoea 177.42 10.92 739 131401 441882 42047313
Parkinsonism 176.00 10.92 190 131950 10433 42478762
Acute kidney injury 174.18 10.92 572 131568 366765 42122430
Diarrhoea 162.26 10.92 807 131333 460042 42029153
Dyskinesia 161.86 10.92 286 131854 25104 42464091
Malignant neoplasm progression 151.88 10.92 73 132067 108327 42380868
Bradypnoea 150.44 10.92 118 132022 4275 42484920
Salivary hypersecretion 149.40 10.92 177 131963 10766 42478429
Bradykinesia 148.42 10.92 128 132012 5308 42483887
Pancytopenia 141.09 10.92 96 132044 117647 42371548
Disease progression 140.27 10.92 143 131997 143513 42345682
Panic attack 138.31 10.92 171 131969 10874 42478321
Speech disorder 137.67 10.92 289 131851 28832 42460363
Hallucination 136.94 10.92 441 131699 57066 42432129
Insomnia 131.69 10.92 718 131422 117535 42371660
Sepsis 131.65 10.92 262 131878 199072 42290123
Interstitial lung disease 127.64 10.92 42 132098 78420 42410775
Pneumonia aspiration 124.68 10.92 390 131750 49688 42439507
Ataxia 121.86 10.92 196 131944 15929 42473266
Delusion 116.72 10.92 183 131957 14551 42474644
Rash 116.60 10.92 453 131687 276501 42212694
Restlessness 116.49 10.92 271 131869 28978 42460217
Dystonia 115.72 10.92 169 131971 12621 42476574
Respiratory depression 115.72 10.92 209 131931 18659 42470536
Thrombocytopenia 112.46 10.92 266 131874 190013 42299182
Hallucination, auditory 107.34 10.92 177 131963 14687 42474508
Pneumonia 105.84 10.92 821 131319 421328 42067867
Cardiac arrest 104.84 10.92 638 131502 108682 42380513
Loss of personal independence in daily activities 102.67 10.92 364 131776 49452 42439743
Serotonin syndrome 102.41 10.92 239 131901 25606 42463589
Muscle rigidity 101.45 10.92 154 131986 11905 42477290
Platelet count decreased 101.36 10.92 171 131969 138410 42350785
Pyrexia 100.79 10.92 762 131378 393280 42095915
On and off phenomenon 99.48 10.92 84 132056 3383 42485812
Psychomotor hyperactivity 99.44 10.92 145 131995 10813 42478382
Neutropenia 98.14 10.92 305 131835 199126 42290069
Irritability 96.42 10.92 246 131894 27882 42461313
Multiple-drug resistance 95.95 10.92 116 132024 7206 42481989
Tremor 95.67 10.92 570 131570 96359 42392836
Drug withdrawal convulsions 93.91 10.92 56 132084 1282 42487913
Bradyphrenia 92.26 10.92 97 132043 5165 42484030
Psychomotor retardation 91.60 10.92 89 132051 4310 42484885
Akathisia 91.53 10.92 136 132004 10315 42478880
Prescribed overdose 90.75 10.92 152 131988 12775 42476420
Atrial fibrillation 89.10 10.92 187 131953 139406 42349789
Victim of crime 88.27 10.92 40 132100 505 42488690
Renal impairment 88.22 10.92 128 132012 110100 42379095
Epilepsy 85.70 10.92 225 131915 25946 42463249
Behaviour disorder 84.78 10.92 107 132033 6947 42482248
Mental impairment 84.04 10.92 143 131997 12174 42477021
Pleural effusion 83.63 10.92 107 132033 97059 42392136
Myelosuppression 83.02 10.92 13 132127 40448 42448747
Hallucination, visual 82.86 10.92 194 131946 20826 42468369
Cardiac failure 81.72 10.92 128 132012 106728 42382467
Unresponsive to stimuli 81.33 10.92 248 131892 31155 42458040
Ascites 79.60 10.92 38 132102 56640 42432555
Disorientation 79.40 10.92 271 131869 36118 42453077
Thinking abnormal 78.83 10.92 104 132036 7057 42482138
Cognitive disorder 78.56 10.92 259 131881 33913 42455282
General physical health deterioration 78.18 10.92 226 131914 151020 42338175
Loss of consciousness 77.41 10.92 521 131619 91833 42397362
Device dislocation 76.01 10.92 107 132033 7724 42481471
Catatonia 73.98 10.92 94 132046 6145 42483050
Cytokine release syndrome 73.88 10.92 23 132117 44504 42444691
Withdrawal syndrome 73.78 10.92 150 131990 14625 42474570
Fall 73.30 10.92 1076 131064 233444 42255751
Disturbance in attention 72.85 10.92 231 131909 29635 42459560
Confusional state 72.69 10.92 817 131323 166780 42322415
COVID-19 72.57 10.92 157 131983 115791 42373404
Tardive dyskinesia 72.30 10.92 98 132042 6826 42482369
Hypertonia 71.77 10.92 83 132057 4918 42484277
Pruritus 71.12 10.92 322 131818 188449 42300746
Renal failure 69.81 10.92 221 131919 143505 42345690
Dysarthria 69.64 10.92 276 131864 39531 42449664
Gait disturbance 69.48 10.92 531 131609 97469 42391726
Granulocytopenia 68.75 10.92 97 132043 7017 42482178
Hyperkalaemia 67.79 10.92 90 132050 80368 42408827
Joint swelling 67.14 10.92 67 132073 67955 42421240
Gastrointestinal haemorrhage 66.55 10.92 126 132014 97600 42391595
Mucosal inflammation 66.48 10.92 35 132105 49339 42439856
Screaming 66.02 10.92 52 132088 1895 42487300
Anger 66.00 10.92 133 132007 12885 42476310
Stoma site discharge 64.74 10.92 46 132094 1430 42487765
Generalised tonic-clonic seizure 64.31 10.92 204 131936 26175 42463020
Posture abnormal 64.08 10.92 57 132083 2464 42486731
Multiple organ dysfunction syndrome 63.57 10.92 128 132012 96907 42392288
Myoclonus 63.48 10.92 154 131986 16911 42472284
Dystonic tremor 63.12 10.92 28 132112 335 42488860
Accidental death 61.63 10.92 61 132079 3022 42486173
Device interaction 61.62 10.92 32 132108 554 42488641
Nervousness 61.29 10.92 132 132008 13400 42475795
Infantile back arching 60.66 10.92 19 132121 75 42489120
Hyperprolactinaemia 60.01 10.92 51 132089 2072 42487123
Mania 59.85 10.92 113 132027 10434 42478761
Myoclonic epilepsy 59.56 10.92 46 132094 1628 42487567
Memory impairment 58.58 10.92 309 131831 49913 42439282
Nausea 58.25 10.92 873 131267 395926 42093269
Infusion related reaction 57.63 10.92 62 132078 60744 42428451
Wrong patient received product 57.45 10.92 63 132077 3520 42485675
Stomatitis 56.38 10.92 44 132096 50285 42438910
Thrombosis 55.34 10.92 79 132061 68432 42420763
Mental disorder 54.99 10.92 151 131989 17878 42471317
Dyspnoea exertional 54.73 10.92 45 132095 50103 42439092
Urticaria 54.42 10.92 91 132049 73945 42415250
Haemoglobin decreased 54.14 10.92 219 131921 132252 42356943
Infection 53.93 10.92 173 131967 111895 42377300
Hyperammonaemia 53.23 10.92 91 132049 7775 42481420
Angioedema 53.06 10.92 33 132107 42444 42446751
Cytomegalovirus infection 53.04 10.92 17 132123 32289 42456906
Cardiac failure congestive 52.65 10.92 117 132023 85485 42403710
Blood creatinine increased 52.11 10.92 171 131969 109832 42379363
Colitis 51.81 10.92 41 132099 46531 42442664
Drug abuser 51.34 10.92 59 132081 3472 42485723
Hypothermia 50.96 10.92 117 132023 12398 42476797
Anaphylactic reaction 50.96 10.92 35 132105 42708 42446487
Pulmonary embolism 50.62 10.92 195 131945 119417 42369778
Freezing phenomenon 50.59 10.92 44 132096 1845 42487350
Septic shock 50.30 10.92 133 132007 91539 42397656
Bradycardia 50.25 10.92 444 131696 85040 42404155
Stoma site erythema 50.22 10.92 34 132106 976 42488219
Blood creatine phosphokinase increased 50.07 10.92 288 131852 48050 42441145
Housebound 49.97 10.92 21 132119 218 42488977
Reduced facial expression 49.96 10.92 40 132100 1493 42487702
Priapism 49.94 10.92 79 132061 6328 42482867
Arthralgia 49.91 10.92 402 131738 204836 42284359
Drooling 49.75 10.92 64 132076 4235 42484960
Tubulointerstitial nephritis 49.37 10.92 18 132122 31530 42457665
Lactic acidosis 48.92 10.92 41 132099 45220 42443975
Brain scan abnormal 48.40 10.92 36 132104 1203 42487992
Decerebrate posture 48.16 10.92 18 132122 133 42489062
Schizophrenia 47.88 10.92 103 132037 10447 42478748
Extrapyramidal disorder 47.64 10.92 135 132005 16277 42472918
Hyperthermia 47.33 10.92 114 132026 12460 42476735
Crying 47.32 10.92 77 132063 6317 42482878
Brain injury 47.19 10.92 85 132055 7570 42481625
Neuropathy peripheral 47.09 10.92 160 131980 101693 42387502
Accidental poisoning 46.96 10.92 36 132104 1260 42487935
Decreased appetite 46.63 10.92 379 131761 192758 42296437
Cough 46.51 10.92 342 131798 177761 42311434
Erythema 46.26 10.92 177 131963 108616 42380579
Middle insomnia 45.79 10.92 85 132055 7748 42481447
Bronchopulmonary aspergillosis 45.40 10.92 4 132136 19425 42469770
Prostate cancer 45.18 10.92 43 132097 44600 42444595
Haematochezia 44.65 10.92 70 132070 58366 42430829
Cogwheel rigidity 44.35 10.92 40 132100 1761 42487434
Myocardial infarction 44.03 10.92 216 131924 123793 42365402
Drug hypersensitivity 44.02 10.92 159 131981 99230 42389965
Drug diversion 43.85 10.92 31 132109 956 42488239
Cerebral artery thrombosis 43.74 10.92 34 132106 1215 42487980
Sleep apnoea syndrome 43.74 10.92 157 131983 21451 42467744
Pneumocystis jirovecii pneumonia 43.61 10.92 12 132128 25169 42464026
Acute myocardial infarction 43.20 10.92 71 132069 58094 42431101
Non-cardiogenic pulmonary oedema 43.01 10.92 30 132110 905 42488290
Visceral congestion 42.84 10.92 30 132110 911 42488284
Tension 42.45 10.92 45 132095 2419 42486776
Drug intolerance 42.38 10.92 119 132021 80305 42408890
Brain oedema 42.32 10.92 129 132011 16198 42472997
Proteinuria 41.63 10.92 10 132130 22973 42466222
Withdrawal arrhythmia 41.37 10.92 13 132127 52 42489143
Abnormal dreams 41.33 10.92 84 132056 8187 42481008
Developmental delay 41.02 10.92 50 132090 3132 42486063
Bone marrow failure 40.93 10.92 26 132114 33067 42456128
Drug screen positive 40.92 10.92 57 132083 4074 42485121
Affect lability 40.36 10.92 56 132084 3988 42485207
Anticonvulsant drug level above therapeutic 40.30 10.92 26 132114 687 42488508
Hypomagnesaemia 40.15 10.92 19 132121 28469 42460726
Lethargy 40.14 10.92 266 131874 46624 42442571
Arthritis 39.74 10.92 43 132097 42022 42447173
Oedema peripheral 39.11 10.92 254 131886 135822 42353373
Drug level increased 39.05 10.92 173 131967 26027 42463168
Atonic seizures 38.88 10.92 21 132119 395 42488800
Pulmonary fibrosis 38.84 10.92 17 132123 26664 42462531
Cerebrovascular accident 38.82 10.92 162 131978 96998 42392197
Melaena 38.42 10.92 38 132102 38708 42450487
Drug ineffective 38.30 10.92 2350 129790 627847 41861348
Rhabdomyolysis 38.27 10.92 390 131750 77629 42411566
Agoraphobia 38.19 10.92 18 132122 250 42488945
Delirium 37.99 10.92 286 131854 52233 42436962
Toxicologic test abnormal 37.91 10.92 22 132118 478 42488717
Coronary artery disease 37.67 10.92 68 132072 53652 42435543
Muscle contracture 37.58 10.92 33 132107 1402 42487793
Disinhibition 37.47 10.92 53 132087 3842 42485353
Vanishing bile duct syndrome 37.36 10.92 37 132103 1834 42487361
Plasma cell myeloma 37.30 10.92 56 132084 47522 42441673
Eyelid function disorder 37.18 10.92 16 132124 177 42489018
Bacterial infection 37.18 10.92 20 132120 27859 42461336
Dysphoria 36.35 10.92 44 132096 2736 42486459
Psychogenic seizure 36.28 10.92 21 132119 454 42488741
Tachycardia 36.02 10.92 475 131665 100612 42388583
Restless legs syndrome 36.01 10.92 87 132053 9527 42479668
Post-anoxic myoclonus 35.86 10.92 9 132131 11 42489184
Myelodysplastic syndrome 35.55 10.92 13 132127 22732 42466463
Haematuria 35.53 10.92 79 132061 57720 42431475
Obsessive-compulsive disorder 35.51 10.92 70 132070 6673 42482522
Neutropenic sepsis 35.39 10.92 4 132136 15942 42473253
Aspergillus infection 35.08 10.92 4 132136 15833 42473362
Accidental overdose 34.89 10.92 177 131963 28153 42461042
Partial seizures 34.77 10.92 64 132076 5795 42483400
Breath holding 34.67 10.92 13 132127 97 42489098
Encephalitis toxic 34.61 10.92 17 132123 260 42488935
Illness anxiety disorder 34.46 10.92 15 132125 171 42489024
Acute myeloid leukaemia 34.31 10.92 13 132127 22243 42466952
Movement disorder 34.31 10.92 112 132028 14586 42474609
Hypertonia neonatal 33.88 10.92 22 132118 588 42488607
Haemorrhage 33.88 10.92 87 132053 60476 42428719
Electrocardiogram QRS complex prolonged 33.80 10.92 63 132077 5760 42483435
Psychotic behaviour 33.48 10.92 26 132114 928 42488267
Substance-induced psychotic disorder 33.42 10.92 43 132097 2846 42486349
Tongue thrust 32.86 10.92 10 132130 35 42489160
Oscillopsia 32.44 10.92 16 132124 247 42488948
Dry skin 32.30 10.92 63 132077 48275 42440920
Electroencephalogram abnormal 32.23 10.92 43 132097 2949 42486246
Peripheral swelling 32.17 10.92 157 131983 90113 42399082
Swelling 32.14 10.92 77 132063 54808 42434387
Compartment syndrome 32.01 10.92 45 132095 3244 42485951
Substance use 31.99 10.92 33 132107 1718 42487477
Bacteraemia 31.90 10.92 19 132121 25021 42464174
Myelopathy 31.84 10.92 42 132098 2849 42486346
Poor quality sleep 31.76 10.92 82 132058 9358 42479837
Neoplasm progression 31.67 10.92 26 132114 28974 42460221
Shock haemorrhagic 31.60 10.92 6 132134 16236 42472959
Balance disorder 31.44 10.92 254 131886 47391 42441804
Cerebral haemorrhage 31.39 10.92 45 132095 38921 42450274
Myasthenia gravis 31.31 10.92 6 132134 16131 42473064
Treatment noncompliance 31.22 10.92 212 131928 37460 42451735
Dehydration 31.15 10.92 285 131855 141482 42347713
Intellectual disability 31.10 10.92 34 132106 1893 42487302
COVID-19 pneumonia 31.10 10.92 14 132126 21599 42467596
Adrenal insufficiency 30.99 10.92 10 132130 18914 42470281
Product substitution issue 30.96 10.92 91 132049 11199 42477996
Torticollis 30.96 10.92 29 132111 1341 42487854
Cytopenia 30.94 10.92 8 132132 17489 42471706
Blood creatine phosphokinase 30.76 10.92 12 132128 101 42489094
Excessive eye blinking 30.44 10.92 21 132119 622 42488573
Rheumatoid arthritis 30.41 10.92 53 132087 42387 42446808
Feeling of despair 30.08 10.92 27 132113 1181 42488014
Bipolar disorder 30.07 10.92 48 132092 3874 42485321
Eczema 29.87 10.92 37 132103 34049 42455146
Thrombotic microangiopathy 29.76 10.92 5 132135 14777 42474418
Blood uric acid increased 29.71 10.92 6 132134 15541 42473654
Gout 29.60 10.92 26 132114 28029 42461166
Tumour lysis syndrome 29.57 10.92 16 132124 22215 42466980
Cerebellar atrophy 29.56 10.92 22 132118 736 42488459
Hyperphosphataemia 29.53 10.92 3 132137 13001 42476194
Impulse-control disorder 29.35 10.92 30 132110 1545 42487650
Basal cell carcinoma 29.32 10.92 17 132123 22716 42466479
Cerebral infarction 29.28 10.92 32 132108 31137 42458058
Meconium aspiration syndrome 29.25 10.92 10 132130 55 42489140
Feeling abnormal 29.20 10.92 338 131802 69448 42419747
Haemophagocytic lymphohistiocytosis 29.19 10.92 10 132130 18212 42470983
Liver disorder 28.87 10.92 49 132091 39595 42449600
Panic disorder 28.80 10.92 27 132113 1250 42487945
Parasomnia 28.74 10.92 18 132122 451 42488744
Suspected suicide 28.68 10.92 61 132079 6138 42483057
Vessel puncture site erythema 28.68 10.92 6 132134 0 42489195
Failure to suspend medication 28.67 10.92 17 132123 385 42488810
Physical assault 28.57 10.92 25 132115 1057 42488138
Drug level above therapeutic 28.35 10.92 59 132081 5847 42483348
Brain hypoxia 28.28 10.92 20 132120 617 42488578
Hepatotoxicity 28.19 10.92 22 132118 25145 42464050
Drug withdrawal syndrome neonatal 28.09 10.92 50 132090 4411 42484784
Road traffic accident 27.65 10.92 125 132015 18968 42470227
Areflexia 27.60 10.92 45 132095 3698 42485497
Blood bilirubin increased 27.43 10.92 56 132084 42196 42446999
Depressed mood 27.34 10.92 144 131996 23240 42465955
Psychiatric symptom 27.31 10.92 48 132092 4193 42485002
Amnesia 27.23 10.92 166 131974 28271 42460924
Nystagmus 27.19 10.92 55 132085 5341 42483854
Contraindicated product administered 27.17 10.92 23 132117 25249 42463946
Coordination abnormal 27.16 10.92 70 132070 7980 42481215
Palmar-plantar erythrodysaesthesia syndrome 27.10 10.92 15 132125 20567 42468628
Panic reaction 27.01 10.92 30 132110 1700 42487495
Abdominal pain 26.84 10.92 422 131718 190049 42299146
Postmortem blood drug level abnormal 26.76 10.92 16 132124 368 42488827
Change in seizure presentation 26.69 10.92 15 132125 306 42488889
End stage renal disease 26.67 10.92 9 132131 16549 42472646
Drug tolerance 26.24 10.92 41 132099 3249 42485946
Drug screen negative 26.17 10.92 13 132127 204 42488991
Hypersomnia 26.08 10.92 102 132038 14516 42474679
Tachyphrenia 26.07 10.92 27 132113 1412 42487783
Choreoathetosis 26.07 10.92 24 132116 1085 42488110
Nephropathy toxic 25.68 10.92 10 132130 16828 42472367
Illusion 25.63 10.92 23 132117 1006 42488189
Sedation complication 25.58 10.92 38 132102 2881 42486314
Generalised anxiety disorder 25.51 10.92 22 132118 912 42488283
Chills 25.31 10.92 179 131961 93887 42395308
Haemoptysis 25.30 10.92 67 132073 46100 42443095
Feeling jittery 25.28 10.92 48 132092 4450 42484745
Impaired driving ability 25.22 10.92 38 132102 2917 42486278
Haematemesis 25.20 10.92 34 132106 30165 42459030
Testicular infarction 25.13 10.92 9 132131 58 42489137
Pseudomonas infection 25.05 10.92 9 132131 15914 42473281
Bipolar I disorder 25.05 10.92 21 132119 837 42488358
Intensive care unit acquired weakness 25.02 10.92 25 132115 1253 42487942
Encephalopathy 24.95 10.92 216 131924 41117 42448078
Chronic kidney disease 24.81 10.92 70 132070 47171 42442024
Blood prolactin increased 24.72 10.92 33 132107 2265 42486930
Sinus tachycardia 24.71 10.92 128 132012 20525 42468670
Clonic convulsion 24.69 10.92 21 132119 854 42488341
Gambling disorder 24.69 10.92 29 132111 1747 42487448
Laboratory test abnormal 24.60 10.92 21 132119 22957 42466238
Cholestasis 24.53 10.92 40 132100 32839 42456356
Epistaxis 24.52 10.92 115 132025 66711 42422484
Poor sucking reflex 24.45 10.92 15 132125 362 42488833
Dementia with Lewy bodies 24.32 10.92 21 132119 872 42488323
Cardiogenic shock 24.20 10.92 46 132094 35594 42453601
Vomiting 23.84 10.92 700 131440 289023 42200172
Blunted affect 23.74 10.92 15 132125 382 42488813
Dependence 23.69 10.92 26 132114 1454 42487741
Hepatic cirrhosis 23.66 10.92 16 132124 19686 42469509
Exposure via ingestion 23.64 10.92 31 132109 2091 42487104
Gastrointestinal hypermotility 23.59 10.92 11 132129 149 42489046
Rectal haemorrhage 23.55 10.92 77 132063 49529 42439666
Cluster headache 23.47 10.92 17 132123 545 42488650
Blood osmolarity decreased 23.45 10.92 18 132122 631 42488564
Colitis ulcerative 23.37 10.92 28 132112 26147 42463048
Stereotypy 23.34 10.92 20 132120 822 42488373
Pain 23.14 10.92 580 131560 244268 42244927
Bruxism 23.10 10.92 31 132109 2138 42487057
Nervous system disorder 23.00 10.92 110 132030 17085 42472110
Persistent depressive disorder 22.93 10.92 16 132124 483 42488712
Hyperarousal 22.82 10.92 8 132132 48 42489147
Red cell distribution width decreased 22.75 10.92 13 132127 274 42488921
Asthenia 22.71 10.92 680 131460 280113 42209082
Blood bicarbonate decreased 22.61 10.92 36 132104 2899 42486296
Paroxysmal perceptual alteration 22.59 10.92 12 132128 218 42488977
Bladder dilatation 22.51 10.92 27 132113 1663 42487532
Bronchiectasis 22.50 10.92 14 132126 18005 42471190
Oedema 22.48 10.92 84 132056 51917 42437278
Upper gastrointestinal haemorrhage 22.48 10.92 37 132103 30262 42458933
Physical abuse 22.46 10.92 6 132134 11 42489184
Somnambulism 22.44 10.92 39 132101 3376 42485819
Myositis 22.39 10.92 9 132131 14857 42474338
Facial bones fracture 22.37 10.92 32 132108 2344 42486851
Talipes 22.37 10.92 31 132109 2205 42486990
Respiratory acidosis 22.34 10.92 56 132084 6275 42482920
Postmortem blood drug level increased 22.31 10.92 16 132124 505 42488690
Stoma site extravasation 22.26 10.92 9 132131 84 42489111
Squamous cell carcinoma of skin 22.16 10.92 6 132134 12720 42476475
Feeling guilty 22.04 10.92 14 132126 360 42488835
Staphylococcal bacteraemia 21.87 10.92 4 132136 11117 42478078
Angina pectoris 21.86 10.92 43 132097 32853 42456342
Post-traumatic stress disorder 21.85 10.92 31 132109 2254 42486941
Lymphadenopathy 21.84 10.92 44 132096 33321 42455874
Rash pruritic 21.42 10.92 45 132095 33558 42455637
Drug detoxification 21.40 10.92 14 132126 379 42488816
Personality disorder 21.40 10.92 22 132118 1141 42488054
International normalised ratio increased 21.35 10.92 77 132063 48091 42441104
Aplastic anaemia 21.26 10.92 6 132134 12378 42476817
Congenital melanocytic naevus 21.21 10.92 6 132134 15 42489180
Anaphylactic shock 21.16 10.92 25 132115 23492 42465703
Death 21.08 10.92 1221 130919 469964 42019231
Hyperhidrosis 21.06 10.92 396 131744 90116 42399079
Inflammation 21.01 10.92 46 132094 33801 42455394
Hypotonia 20.94 10.92 71 132069 9428 42479767
Graft versus host disease 20.86 10.92 7 132133 12918 42476277
Hyperkinesia 20.86 10.92 29 132111 2069 42487126
Patient uncooperative 20.79 10.92 17 132123 654 42488541
Dissociative disorder 20.77 10.92 17 132123 655 42488540
Stupor 20.71 10.92 36 132104 3117 42486078
Intelligence test abnormal 20.70 10.92 7 132133 37 42489158
Vasculitis 20.70 10.92 16 132124 18378 42470817
Ehlers-Danlos syndrome 20.55 10.92 7 132133 38 42489157
Abdominal distension 20.54 10.92 134 132006 71601 42417594
Hypertension 20.45 10.92 380 131760 166824 42322371
Impulsive behaviour 20.44 10.92 31 132109 2394 42486801
Obsessive-compulsive personality disorder 20.30 10.92 10 132130 154 42489041
Arthropathy 20.27 10.92 38 132102 29559 42459636
Hypokinesia 20.21 10.92 72 132068 9799 42479396
Cholestatic liver injury 20.13 10.92 39 132101 3670 42485525
Tooth injury 20.06 10.92 22 132118 1229 42487966
Weight increased 20.06 10.92 457 131683 107526 42381669
Akinesia 19.99 10.92 31 132109 2441 42486754
Dysgeusia 19.98 10.92 48 132092 34141 42455054
Clinomania 19.96 10.92 7 132133 42 42489153
Language disorder 19.96 10.92 31 132109 2444 42486751
Gaze palsy 19.94 10.92 27 132113 1878 42487317
Embedded device 19.91 10.92 14 132126 428 42488767
Cardiac failure chronic 19.89 10.92 3 132137 9598 42479597
Motor dysfunction 19.85 10.92 63 132077 8083 42481112
Antidepressant drug level increased 19.72 10.92 11 132129 221 42488974
Stoma site inflammation 19.72 10.92 15 132125 519 42488676
Hypomania 19.65 10.92 31 132109 2477 42486718
Flat affect 19.61 10.92 20 132120 1027 42488168
Fluid retention 19.61 10.92 43 132097 31576 42457619
Apathy 19.57 10.92 64 132076 8342 42480853
Treatment failure 19.48 10.92 114 132026 62510 42426685
Deep vein thrombosis 19.47 10.92 149 131991 76808 42412387
Clostridium difficile infection 19.43 10.92 25 132115 22634 42466561
Developmental regression 19.43 10.92 7 132133 46 42489149
Neurotoxicity 19.36 10.92 27 132113 23624 42465571
Poverty of speech 19.33 10.92 11 132129 230 42488965
Drug withdrawal maintenance therapy 19.31 10.92 10 132130 172 42489023
Incoherent 19.29 10.92 44 132096 4641 42484554
Pulmonary hypertension 19.20 10.92 27 132113 23542 42465653
Sexual dysfunction 18.95 10.92 55 132085 6720 42482475
Postoperative respiratory failure 18.84 10.92 9 132131 129 42489066
Multiple sclerosis 18.73 10.92 59 132081 7539 42481656
Heat stroke 18.67 10.92 20 132120 1088 42488107
Myalgia 18.64 10.92 199 131941 95881 42393314
Parkinsonian gait 18.57 10.92 15 132125 567 42488628
HIV peripheral neuropathy 18.36 10.92 6 132134 28 42489167
Purpura fulminans 18.33 10.92 10 132130 192 42489003
Antipsychotic drug level increased 18.31 10.92 43 132097 4623 42484572
Major depression 18.27 10.92 47 132093 5351 42483844
Myelocyte count increased 18.24 10.92 13 132127 406 42488789
Erectile dysfunction 18.20 10.92 136 132004 24777 42464418
Atrial flutter 18.18 10.92 16 132124 17235 42471960
Oropharyngeal pain 18.16 10.92 69 132071 42441 42446754
Petit mal epilepsy 18.15 10.92 37 132103 3613 42485582
Hypophosphataemia 18.07 10.92 23 132117 20922 42468273
Haemorrhage intracranial 18.05 10.92 16 132124 17176 42472019
Opsoclonus myoclonus 18.01 10.92 8 132132 96 42489099
Oesophageal carcinoma 18.00 10.92 4 132136 9692 42479503
Hyperventilation 17.94 10.92 34 132106 3148 42486047
Pain in extremity 17.88 10.92 344 131796 150260 42338935
Suicidal behaviour 17.87 10.92 23 132117 1523 42487672
Pulmonary alveolar haemorrhage 17.83 10.92 12 132128 14804 42474391
Self esteem decreased 17.83 10.92 14 132126 508 42488687
Muscle spasticity 17.77 10.92 54 132086 6768 42482427
Eye movement disorder 17.72 10.92 44 132096 4901 42484294
Venoocclusive liver disease 17.67 10.92 5 132135 10297 42478898
BK virus infection 17.62 10.92 3 132137 8781 42480414
Mental status changes 17.62 10.92 204 131936 41911 42447284
Blood test abnormal 17.59 10.92 9 132131 12897 42476298
Persecutory delusion 17.57 10.92 36 132104 3528 42485667
Personality change 17.54 10.92 48 132092 5671 42483524
Stoma site infection 17.48 10.92 18 132122 935 42488260
Swelling face 17.48 10.92 37 132103 27517 42461678
Skin ulcer 17.42 10.92 33 132107 25568 42463627
Osteonecrosis of jaw 17.41 10.92 20 132120 19029 42470166
Neutrophil count decreased 17.38 10.92 120 132020 63295 42425900
Electrocardiogram QT shortened 17.32 10.92 9 132131 156 42489039
Inappropriate schedule of product administration 17.28 10.92 202 131938 95700 42393495
Lymphopenia 17.27 10.92 25 132115 21538 42467657
Rash maculo-papular 17.26 10.92 59 132081 37444 42451751
Pneumothorax 17.23 10.92 29 132111 23514 42465681
Autonomic nervous system imbalance 17.20 10.92 33 132107 3083 42486112
Obsessive thoughts 17.19 10.92 17 132123 841 42488354
Homicidal ideation 17.19 10.92 31 132109 2763 42486432
Libido increased 17.09 10.92 18 132122 960 42488235
Logorrhoea 17.09 10.92 31 132109 2776 42486419
Phaeochromocytoma malignant 17.07 10.92 7 132133 68 42489127
Staphylococcal sepsis 17.05 10.92 7 132133 11407 42477788
Hypoalbuminaemia 17.04 10.92 14 132126 15596 42473599
Anticonvulsant drug level decreased 17.03 10.92 20 132120 1205 42487990
Cholangitis 16.99 10.92 6 132134 10721 42478474
Seizure cluster 16.97 10.92 11 132129 293 42488902
Hyperglycaemia 16.77 10.92 79 132061 45780 42443415
Depersonalisation/derealisation disorder 16.70 10.92 15 132125 657 42488538
Dopamine dysregulation syndrome 16.68 10.92 14 132126 559 42488636
Rapid eye movement sleep behaviour disorder 16.61 10.92 11 132129 304 42488891
Injection site pain 16.53 10.92 108 132032 57690 42431505
Hyperchloraemia 16.45 10.92 14 132126 570 42488625
Neurosis 16.44 10.92 9 132131 174 42489021
Appendicitis 16.41 10.92 24 132116 20589 42468606
Epstein-Barr virus infection 16.15 10.92 5 132135 9713 42479482
Staphylococcal infection 16.14 10.92 61 132079 37582 42451613
Hostility 16.09 10.92 16 132124 797 42488398
Spinal shock 16.09 10.92 6 132134 44 42489151
Stoma site hypergranulation 16.02 10.92 10 132130 249 42488946
Fatigue 16.02 10.92 1149 130991 434492 42054703
Pneumonia bacterial 16.01 10.92 15 132125 15677 42473518
Off label use 15.94 10.92 1735 130405 636600 41852595
Hypokalaemia 15.82 10.92 144 131996 71577 42417618
Syncope 15.81 10.92 215 131925 99191 42390004
Mutism 15.73 10.92 21 132119 1441 42487754
Haematuria traumatic 15.71 10.92 11 132129 334 42488861
Breath sounds abnormal 15.65 10.92 9 132131 12084 42477111
Alopecia 15.65 10.92 43 132097 29233 42459962
Asphyxia 15.59 10.92 59 132081 8267 42480928
Clonus 15.55 10.92 34 132106 3486 42485709
Borderline personality disorder 15.48 10.92 12 132128 427 42488768
Antisocial behaviour 15.48 10.92 12 132128 427 42488768
Diffuse large B-cell lymphoma 15.47 10.92 5 132135 9449 42479746
Candida infection 15.47 10.92 27 132113 21583 42467612
Escherichia infection 15.45 10.92 8 132132 11388 42477807
Social avoidant behaviour 15.44 10.92 33 132107 3331 42485864
Infantile spasms 15.37 10.92 10 132130 268 42488927
Ulcer 15.31 10.92 17 132123 16424 42472771
Dysstasia 15.28 10.92 85 132055 14001 42475194
Inappropriate affect 15.19 10.92 15 132125 741 42488454
Pneumonitis 15.18 10.92 72 132068 41646 42447549
Asterixis 15.16 10.92 20 132120 1357 42487838
Systemic lupus erythematosus 15.14 10.92 5 132135 9319 42479876
Injection site exfoliation 15.13 10.92 6 132134 53 42489142
Hyperphagia 15.01 10.92 22 132118 1648 42487547
Cytotoxic oedema 14.98 10.92 9 132131 209 42488986
Hallucinations, mixed 14.97 10.92 33 132107 3402 42485793
Substance dependence 14.93 10.92 14 132126 648 42488547
Ventricular pre-excitation 14.86 10.92 5 132135 26 42489169
Injection site dryness 14.84 10.92 6 132134 56 42489139
Postictal paralysis 14.83 10.92 11 132129 366 42488829
CADASIL 14.80 10.92 7 132133 98 42489097
Muscle twitching 14.78 10.92 74 132066 11706 42477489
Paradoxical drug reaction 14.76 10.92 40 132100 4698 42484497
Cellulitis 14.76 10.92 121 132019 61464 42427731
Hypervolaemia 14.71 10.92 31 132109 23094 42466101
Blood calcium increased 14.69 10.92 4 132136 8450 42480745
Pneumonia fungal 14.68 10.92 5 132135 9141 42480054
Intestinal dilatation 14.66 10.92 21 132119 1540 42487655
Iron deficiency 14.65 10.92 8 132132 11053 42478142
Post transplant lymphoproliferative disorder 14.61 10.92 5 132135 9115 42480080
Dysmetria 14.59 10.92 15 132125 778 42488417
Hyponatraemia 14.54 10.92 224 131916 101238 42387957
Blood loss anaemia 14.49 10.92 6 132134 9730 42479465
Full blood count decreased 14.43 10.92 26 132114 20534 42468661
Stoma site pain 14.43 10.92 15 132125 788 42488407
Bladder cancer 14.42 10.92 19 132121 17028 42472167
Ejaculation disorder 14.38 10.92 17 132123 1031 42488164
Lennox-Gastaut syndrome 14.37 10.92 7 132133 105 42489090
Diet refusal 14.36 10.92 10 132130 301 42488894
Senile dementia 14.26 10.92 5 132135 30 42489165
Postmortem blood drug level 14.24 10.92 8 132132 163 42489032
Herpes zoster 14.20 10.92 67 132073 38810 42450385
Abdominal pain upper 14.11 10.92 176 131964 82433 42406762
Cerebral disorder 14.09 10.92 30 132110 3020 42486175
Diverticulitis 14.09 10.92 31 132109 22742 42466453
Enteritis 14.07 10.92 8 132132 10808 42478387
Medication error 14.05 10.92 161 131979 32993 42456202
Metastases to liver 14.01 10.92 18 132122 16308 42472887
Galactorrhoea 14.01 10.92 12 132128 493 42488702
Jealous delusion 13.94 10.92 11 132129 402 42488793
Libido decreased 13.89 10.92 41 132099 5057 42484138
Oromandibular dystonia 13.84 10.92 13 132127 603 42488592
Tuberculosis 13.83 10.92 7 132133 10092 42479103
Brain malformation 13.82 10.92 8 132132 173 42489022
Immune effector cell-associated neurotoxicity syndrome 13.81 10.92 6 132134 9455 42479740
Skin exfoliation 13.81 10.92 74 132066 41479 42447716
Purpura 13.80 10.92 10 132130 11869 42477326
Parkinsonian rest tremor 13.79 10.92 10 132130 321 42488874
Hypothyroidism 13.75 10.92 52 132088 32032 42457163
Emotional disorder 13.74 10.92 47 132093 6267 42482928
Cholecystitis 13.74 10.92 12 132128 12976 42476219
Blepharospasm 13.73 10.92 19 132121 1349 42487846
Attention deficit hyperactivity disorder 13.71 10.92 30 132110 3078 42486117
Aortic stenosis 13.66 10.92 5 132135 8740 42480455
Cystitis haemorrhagic 13.65 10.92 3 132137 7326 42481869
Lung neoplasm malignant 13.63 10.92 24 132116 19123 42470072
Leukopenia 13.63 10.92 157 131983 74589 42414606
Monorchidism 13.61 10.92 4 132136 12 42489183
Locomotive syndrome 13.61 10.92 4 132136 12 42489183
Chest discomfort 13.48 10.92 129 132011 63487 42425708
Low birth weight baby 13.48 10.92 7 132133 9948 42479247
Lip swelling 13.46 10.92 24 132116 19029 42470166
Hypercalcaemia 13.44 10.92 22 132118 18036 42471159
Blood lactate dehydrogenase increased 13.43 10.92 39 132101 26042 42463153
Renal injury 13.42 10.92 11 132129 12269 42476926
Sleep paralysis 13.40 10.92 10 132130 336 42488859
Niemann-Pick disease 13.37 10.92 4 132136 13 42489182
Frequent bowel movements 13.36 10.92 29 132111 21378 42467817
Malaise 13.36 10.92 530 131610 211626 42277569
Communication disorder 13.30 10.92 28 132112 2797 42486398
Anorgasmia 13.27 10.92 17 132123 1120 42488075
Localised infection 13.22 10.92 27 132113 20346 42468849
Mood altered 13.22 10.92 67 132073 10651 42478544
Renal hypertension 13.15 10.92 9 132131 263 42488932
Delayed fontanelle closure 13.14 10.92 5 132135 39 42489156
Fear 13.14 10.92 68 132072 10897 42478298
Conduction disorder 13.09 10.92 26 132114 2492 42486703
Metastases to bone 13.05 10.92 16 132124 14793 42474402
Skin lesion 13.02 10.92 42 132098 27132 42462063
Lung disorder 12.98 10.92 91 132049 47832 42441363
Chorea 12.94 10.92 19 132121 1425 42487770
Glossopharyngeal nerve disorder 12.93 10.92 5 132135 41 42489154
Osteomyelitis 12.83 10.92 23 132117 18200 42470995
Disseminated intravascular coagulation 12.82 10.92 37 132103 24757 42464438
Psoriasis 12.82 10.92 93 132047 48511 42440684
Sleep-related eating disorder 12.75 10.92 10 132130 362 42488833
Metamyelocyte count increased 12.73 10.92 11 132129 457 42488738
Alanine aminotransferase increased 12.72 10.92 195 131945 88211 42400984
Lower gastrointestinal haemorrhage 12.68 10.92 9 132131 10799 42478396
C-reactive protein increased 12.59 10.92 131 132009 63429 42425766
Anion gap increased 12.59 10.92 23 132117 2071 42487124
Product complaint 12.58 10.92 44 132096 5933 42483262
Feeling drunk 12.57 10.92 24 132116 2234 42486961
Drug ineffective for unapproved indication 12.53 10.92 207 131933 45956 42443239
Rash erythematous 12.50 10.92 54 132086 32037 42457158
Defect conduction intraventricular 12.47 10.92 11 132129 470 42488725
Lumbar hernia 12.40 10.92 7 132133 144 42489051
Cutaneous vasculitis 12.39 10.92 3 132137 6857 42482338
Pre-existing condition improved 12.39 10.92 28 132112 2935 42486260
Drop attacks 12.39 10.92 12 132128 579 42488616
Hypothermia neonatal 12.32 10.92 6 132134 90 42489105
Organising pneumonia 12.30 10.92 4 132136 7528 42481667
Bedridden 12.29 10.92 35 132105 4230 42484965
Anhidrosis 12.28 10.92 8 132132 215 42488980
Back pain 12.27 10.92 340 131800 141436 42347759
Pseudodementia 12.27 10.92 3 132137 3 42489192
Antimitochondrial antibody 12.27 10.92 3 132137 3 42489192
Vagal nerve stimulator implantation 12.26 10.92 6 132134 91 42489104
Optic nerve operation 12.26 10.92 11 132129 481 42488714
Device related infection 12.23 10.92 28 132112 20251 42468944
Weight abnormal 12.23 10.92 15 132125 946 42488249
Somatic delusion 12.20 10.92 6 132134 92 42489103
Blood pressure systolic increased 12.20 10.92 45 132095 27923 42461272
Activated partial thromboplastin time prolonged 12.19 10.92 19 132121 15884 42473311
Ammonia abnormal 12.14 10.92 6 132134 93 42489102
Hyperosmolar state 12.11 10.92 11 132129 489 42488706
Rhinorrhoea 12.08 10.92 54 132086 31740 42457455
Accommodation disorder 12.02 10.92 9 132131 304 42488891
Pulmonary oedema 12.02 10.92 232 131908 53040 42436155
Nephrolithiasis 12.02 10.92 66 132074 36764 42452431
Myocarditis 11.97 10.92 100 132040 18838 42470357
Gallbladder polyp 11.94 10.92 11 132129 498 42488697
Haemolytic anaemia 11.90 10.92 12 132128 12115 42477080
Mumps 11.86 10.92 6 132134 98 42489097
Dissociative identity disorder 11.85 10.92 4 132136 21 42489174
Uveitis 11.83 10.92 7 132133 9251 42479944
Open reduction of fracture 11.81 10.92 6 132134 99 42489096
Affective disorder 11.80 10.92 43 132097 5917 42483278
Fibroma 11.79 10.92 10 132130 405 42488790
Hyperreflexia 11.79 10.92 31 132109 3576 42485619
Nasal septum deviation 11.72 10.92 17 132123 1261 42487934
Adverse drug reaction 11.72 10.92 68 132072 37366 42451829
Enterococcal infection 11.71 10.92 12 132128 12027 42477168
Heparin-induced thrombocytopenia 11.70 10.92 3 132137 6594 42482601
Opisthotonus 11.68 10.92 12 132128 622 42488573
White blood cell count decreased 11.66 10.92 257 131883 110139 42379056
Wheezing 11.64 10.92 111 132029 54670 42434525
Skin cancer 11.64 10.92 11 132129 11451 42477744
Hypocalcaemia 11.62 10.92 51 132089 30122 42459073
Impaired healing 11.58 10.92 22 132118 17031 42472164
Pyelonephritis 11.58 10.92 5 132135 7909 42481286
Poor venous access 11.58 10.92 4 132136 7248 42481947
Hypoxic-ischaemic encephalopathy 11.57 10.92 39 132101 5163 42484032
Drug eruption 11.52 10.92 35 132105 23040 42466155
Dementia 11.49 10.92 89 132051 16391 42472804
Urinary incontinence 11.43 10.92 110 132030 21558 42467637
Lissencephaly 11.41 10.92 3 132137 5 42489190
Multiple system atrophy 11.41 10.92 7 132133 169 42489026
Perineal infection 11.40 10.92 12 132128 640 42488555
Immunosuppression 11.36 10.92 6 132134 8447 42480748
Klebsiella infection 11.36 10.92 11 132129 11321 42477874
Prostatic specific antigen increased 11.35 10.92 22 132118 16903 42472292
Infective pulmonary exacerbation of cystic fibrosis 11.35 10.92 5 132135 7813 42481382
Developmental hip dysplasia 11.33 10.92 9 132131 332 42488863
Ammonia increased 11.32 10.92 36 132104 4623 42484572
Transient ischaemic attack 11.26 10.92 60 132080 33679 42455516
Diabetes mellitus inadequate control 11.22 10.92 19 132121 15371 42473824
Drug-induced liver injury 11.20 10.92 71 132069 38202 42450993
Homicide 11.19 10.92 14 132126 901 42488294
Dermatitis acneiform 11.15 10.92 5 132135 7734 42481461
Renal disorder 11.15 10.92 49 132091 28931 42460264
Posterior reversible encephalopathy syndrome 11.14 10.92 14 132126 12807 42476388
Compression fracture 11.07 10.92 31 132109 3711 42485484
Eustachian tube disorder 11.06 10.92 3 132137 6 42489189
Acidosis hyperchloraemic 10.98 10.92 12 132128 668 42488527
Tonic convulsion 10.97 10.92 19 132121 1640 42487555
Infected dermal cyst 10.97 10.92 14 132126 919 42488276
Ventricular fibrillation 10.95 10.92 52 132088 30071 42459124

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 4610.69 10.18 4474 309659 237907 110037259
Drug abuse 2716.30 10.18 2916 311217 174495 110100671
Toxicity to various agents 2420.68 10.18 4641 309492 475914 109799252
Intentional overdose 1257.58 10.18 1710 312423 130791 110144375
Somnolence 1181.37 10.18 2608 311525 294841 109980325
Suicide attempt 1169.17 10.18 1455 312678 101939 110173227
Respiratory arrest 1021.19 10.18 1031 313102 57268 110217898
Cardio-respiratory arrest 927.83 10.18 1379 312754 114457 110160709
Sopor 887.51 10.18 775 313358 35771 110239395
Suicidal ideation 863.35 10.18 1194 312939 92743 110182423
Overdose 786.05 10.18 1921 312212 231873 110043293
Psychotic disorder 753.10 10.18 823 313310 50114 110225052
Depression 713.38 10.18 2251 311882 315084 109960082
Seizure 695.71 10.18 1772 312361 219413 110055753
Drug dependence 673.99 10.18 770 313363 49250 110225916
Drug interaction 652.00 10.18 2980 311153 497203 109777963
Coma 641.14 10.18 1179 312954 116690 110158476
Synovitis 611.89 10.18 43 314090 274049 110001117
Aggression 605.55 10.18 793 313340 58417 110216749
Dissociation 600.91 10.18 365 313768 9477 110265689
Pemphigus 585.97 10.18 4 314129 214566 110060600
Cardiac arrest 562.16 10.18 1521 312612 195232 110079934
Agitation 555.61 10.18 1083 313050 111968 110163198
Drug withdrawal syndrome 554.08 10.18 610 313523 37444 110237722
Poisoning 547.04 10.18 535 313598 28570 110246596
Hand deformity 529.14 10.18 21 314112 218485 110056681
Neuroleptic malignant syndrome 518.61 10.18 559 313574 33500 110241666
Miosis 511.34 10.18 455 313678 21528 110253638
Contraindicated product administered 510.57 10.18 55 314078 248212 110026954
Systemic lupus erythematosus 506.46 10.18 63 314070 254275 110020891
Pericarditis 501.99 10.18 30 314103 219084 110056082
Sedation 497.77 10.18 787 313346 68896 110206270
Drug use disorder 497.56 10.18 412 313721 17662 110257504
Infusion related reaction 482.26 10.18 240 313893 380922 109894244
Intentional self-injury 477.09 10.18 560 313573 36869 110238297
Helicobacter infection 475.70 10.18 8 314125 181869 110093297
Schizophrenia 466.93 10.18 431 313702 21395 110253771
Depressed level of consciousness 464.75 10.18 1002 313131 111276 110163890
Substance use disorder 459.63 10.18 276 313857 7014 110268152
Abnormal behaviour 449.99 10.18 555 313578 38484 110236682
Glossodynia 446.89 10.18 53 314080 221951 110053215
Drug intolerance 406.23 10.18 335 313798 406177 109868989
Anxiety 395.33 10.18 1982 312151 343096 109932070
Folliculitis 393.15 10.18 20 314113 167633 110107533
Substance abuse 391.67 10.18 307 313826 12156 110263010
Joint swelling 386.07 10.18 413 313720 442432 109832734
Arthropathy 383.73 10.18 168 313965 287354 109987812
Impaired healing 358.67 10.18 63 314070 196654 110078512
General physical health deterioration 354.95 10.18 411 313722 424884 109850282
Stomatitis 352.64 10.18 163 313970 270079 110005087
Tremor 350.22 10.18 1316 312817 200916 110074250
C-reactive protein abnormal 346.52 10.18 4 314129 129691 110145475
Serotonin syndrome 346.13 10.18 611 313522 58542 110216624
Intentional product misuse 345.46 10.18 993 313140 131911 110143255
Altered state of consciousness 343.37 10.18 600 313533 57026 110218140
Rheumatoid factor positive 343.35 10.18 6 314127 131634 110143532
Paranoia 340.22 10.18 367 313766 22007 110253159
Psychiatric decompensation 339.66 10.18 209 313924 5556 110269610
Rash 338.76 10.18 1197 312936 819767 109455399
Nasal oedema 335.86 10.18 221 313912 6618 110268548
Panic attack 334.44 10.18 412 313721 28528 110246638
Rheumatic fever 326.51 10.18 4 314129 122575 110152591
Mydriasis 325.68 10.18 357 313776 21800 110253366
Muscle injury 323.31 10.18 19 314114 140788 110134378
Febrile neutropenia 321.41 10.18 257 313876 316510 109958656
Wound 319.14 10.18 133 314000 234304 110040862
Swelling 316.46 10.18 318 313815 350723 109924443
Dyskinesia 306.97 10.18 536 313597 50910 110224256
Alopecia 303.75 10.18 353 313780 364400 109910766
Hypersensitivity 298.27 10.18 428 313705 403570 109871596
Speech disorder 294.11 10.18 583 313550 60986 110214180
Stubbornness 287.45 10.18 88 314045 353 110274813
Irritability 286.41 10.18 499 313634 47310 110227856
Acute kidney injury 264.86 10.18 922 313211 634508 109640658
Irritable bowel syndrome 263.94 10.18 70 314063 164145 110111021
Rheumatoid arthritis 262.54 10.18 278 313855 299335 109975831
Anaemia 261.59 10.18 746 313387 546340 109728826
Unresponsive to stimuli 251.05 10.18 558 313575 63232 110211934
Treatment failure 247.68 10.18 253 313880 276981 109998185
Abdominal discomfort 246.21 10.18 465 313668 393393 109881773
Ataxia 240.21 10.18 358 313775 29750 110245416
Infection 237.66 10.18 415 313718 361785 109913381
Withdrawal syndrome 234.59 10.18 362 313771 31018 110244148
Facet joint syndrome 232.01 10.18 10 314123 96818 110178348
Maternal exposure during pregnancy 230.65 10.18 230 313903 254653 110020513
Dystonia 229.44 10.18 323 313810 25482 110249684
Thinking abnormal 227.84 10.18 247 313886 14893 110260273
Status epilepticus 227.37 10.18 358 313775 31213 110243953
Tardive dyskinesia 224.69 10.18 233 313900 13346 110261820
Pneumonia aspiration 218.87 10.18 615 313518 80618 110194548
Lip dry 216.73 10.18 18 314115 100065 110175101
Psychomotor skills impaired 215.63 10.18 171 313962 6887 110268279
Depression suicidal 215.54 10.18 147 313986 4677 110270489
Tearfulness 212.81 10.18 173 313960 7222 110267944
Ill-defined disorder 211.79 10.18 90 314043 156763 110118403
Restlessness 208.99 10.18 481 313652 55778 110219388
Drug withdrawal convulsions 203.43 10.18 111 314022 2338 110272828
Bursitis 202.02 10.18 59 314074 129859 110145307
Hallucination 201.84 10.18 691 313442 100741 110174425
Asthma 201.55 10.18 1309 312824 248982 110026184
Myelosuppression 201.47 10.18 18 314115 94322 110180844
Loss of consciousness 200.00 10.18 1092 313041 195214 110079952
Liver injury 198.82 10.18 89 314044 150324 110124842
Lower respiratory tract infection 198.29 10.18 239 313894 242867 110032299
Psoriatic arthropathy 197.78 10.18 161 313972 196600 110078566
Parkinsonism 196.20 10.18 277 313856 21910 110253256
Respiratory depression 195.58 10.18 337 313796 31664 110243502
Mental disorder 189.70 10.18 371 313762 38420 110236746
Therapeutic product effect decreased 187.02 10.18 252 313881 244064 110031102
Muscle rigidity 184.95 10.18 281 313852 23750 110251416
Bradykinesia 183.72 10.18 188 313945 10600 110264566
Rhinitis allergic 183.11 10.18 240 313893 17682 110257484
Mania 180.01 10.18 257 313876 20539 110254627
Inflammation 179.87 10.18 170 313963 193068 110082098
Bradyphrenia 179.40 10.18 193 313940 11535 110263631
Thrombocytopenia 179.19 10.18 459 313674 348426 109926740
Hepatic enzyme increased 178.38 10.18 405 313728 320487 109954679
Depressive symptom 177.72 10.18 165 313968 8249 110266917
Sleep disorder due to general medical condition, insomnia type 175.60 10.18 42 314091 105601 110169565
Crying 175.48 10.18 284 313849 25344 110249822
Akathisia 174.59 10.18 229 313904 16884 110258282
Dysarthria 174.36 10.18 581 313552 83540 110191626
Gastrointestinal disorder 173.86 10.18 261 313872 241691 110033475
Hallucination, auditory 173.28 10.18 287 313846 26110 110249056
Multiple-drug resistance 171.93 10.18 200 313933 13035 110262131
Pulmonary fibrosis 170.73 10.18 40 314093 102002 110173164
Blister 170.53 10.18 238 313895 227138 110048028
Sensitisation 170.23 10.18 120 314013 4031 110271135
Diarrhoea 167.22 10.18 2258 311875 1137247 109137919
Salivary hypersecretion 166.80 10.18 226 313907 17195 110257971
Malignant neoplasm progression 166.71 10.18 150 313983 174417 110100749
Polycystic ovaries 165.71 10.18 125 314008 4671 110270495
Peripheral venous disease 164.54 10.18 22 314111 84095 110191071
Musculoskeletal pain 163.44 10.18 167 313966 182856 110092310
Wound infection 163.02 10.18 37 314096 96428 110178738
Pancytopenia 162.66 10.18 214 313919 209399 110065767
Disease progression 162.38 10.18 277 313856 243757 110031409
Restless legs syndrome 161.99 10.18 268 313865 24358 110250808
Joint range of motion decreased 159.59 10.18 73 314060 121759 110153407
Balance disorder 159.15 10.18 705 313428 115855 110159311
Disturbance in attention 157.91 10.18 460 313673 61535 110213631
Neutropenia 154.88 10.18 545 313588 374075 109901091
Disorientation 154.45 10.18 497 313636 70174 110204992
Delusion 154.22 10.18 257 313876 23498 110251668
Discomfort 152.91 10.18 233 313900 214474 110060692
Psychomotor hyperactivity 151.68 10.18 234 313899 20043 110255123
Arthralgia 150.17 10.18 1453 312680 778179 109496987
Lung disorder 147.87 10.18 176 313957 179871 110095295
On and off phenomenon 147.77 10.18 113 314020 4311 110270855
Cogwheel rigidity 144.95 10.18 104 314029 3594 110271572
Drooling 141.22 10.18 135 313998 7004 110268162
Generalised tonic-clonic seizure 140.49 10.18 407 313726 54273 110220893
Anger 140.29 10.18 218 313915 18789 110256377
Feeling of despair 140.20 10.18 103 314030 3695 110271471
Interstitial lung disease 140.02 10.18 114 314019 139220 110135946
Ejection fraction 139.08 10.18 93 314040 2862 110272304
Mobility decreased 139.05 10.18 291 313842 237131 110038035
Blood cholesterol increased 138.97 10.18 193 313940 184592 110090574
Mood altered 138.43 10.18 231 313902 21144 110254022
Sepsis 137.46 10.18 473 313660 326873 109948293
Respiratory tract infection 136.47 10.18 481 313652 71136 110204030
Urticaria 135.07 10.18 459 313674 318398 109956768
Liver disorder 133.70 10.18 124 314009 142119 110133047
Multiple sclerosis 133.28 10.18 252 313881 25446 110249720
Insomnia 133.11 10.18 1588 312545 359002 109916164
Live birth 131.64 10.18 20 314113 69464 110205702
Type 2 diabetes mellitus 128.45 10.18 190 313943 177042 110098124
C-reactive protein increased 126.85 10.18 268 313865 217651 110057515
Nail disorder 126.60 10.18 10 314123 57925 110217241
Granulocytopenia 126.39 10.18 168 313965 12547 110262619
Hypercholesterolaemia 126.04 10.18 50 314083 90787 110184379
Nervousness 125.92 10.18 305 313828 36546 110238620
Pyrexia 125.82 10.18 1796 312337 896469 109378697
Fall 123.96 10.18 2404 311729 601078 109674088
Sleep apnoea syndrome 122.75 10.18 320 313813 40127 110235039
Feeling abnormal 122.30 10.18 906 313227 179805 110095361
Night sweats 122.19 10.18 120 314013 133863 110141303
Peripheral swelling 119.06 10.18 667 313466 403367 109871799
Hyperhidrosis 116.68 10.18 921 313212 186377 110088789
Bradypnoea 116.21 10.18 133 314000 8516 110266650
Atrial fibrillation 115.64 10.18 305 313828 229337 110045829
Jaundice cholestatic 115.52 10.18 173 313960 14435 110260731
Psychomotor retardation 115.29 10.18 126 314007 7666 110267500
Renal impairment 112.85 10.18 228 313905 188217 110086949
Osteoarthritis 111.90 10.18 218 313915 182405 110092761
Hypersomnia 110.98 10.18 246 313887 27815 110247351
Pleural effusion 109.88 10.18 211 313922 177498 110097668
Nasal polyps 109.67 10.18 160 313973 13040 110262126
Behaviour disorder 109.30 10.18 136 313997 9511 110265655
Autoimmune disorder 108.89 10.18 26 314107 65457 110209709
Nasopharyngitis 108.75 10.18 665 313468 393696 109881470
Blood creatine phosphokinase increased 107.41 10.18 452 313681 72625 110202541
Catatonia 105.77 10.18 145 313988 11155 110264011
Lethargy 104.45 10.18 534 313599 93042 110182124
Bone erosion 104.20 10.18 7 314126 46364 110228802
Cholelithiasis 104.13 10.18 406 313727 63016 110212150
Myoglobin urine present 103.15 10.18 51 314082 869 110274297
Urinary tract discomfort 103.02 10.18 52 314081 928 110274238
Drug abuser 102.69 10.18 100 314033 5309 110269857
Hypertension 102.60 10.18 940 313193 509144 109766022
Total lung capacity increased 101.75 10.18 97 314036 5015 110270151
Mental impairment 101.68 10.18 209 313924 22430 110252736
Taste disorder 101.08 10.18 30 314103 65357 110209809
Gait disturbance 100.77 10.18 1221 312912 276987 109998179
Emotional disorder 99.82 10.18 171 313962 15989 110259177
Hypokinesia 99.81 10.18 203 313930 21623 110253543
Electrocardiogram QT prolonged 98.34 10.18 587 313546 108373 110166793
Pruritus 98.31 10.18 1117 313016 580443 109694723
Middle insomnia 97.71 10.18 194 313939 20308 110254858
Gastric pH decreased 97.70 10.18 51 314082 979 110274187
Movement disorder 97.43 10.18 275 313858 36129 110239037
Myoclonus 97.01 10.18 258 313875 32740 110242426
Hyperprolactinaemia 96.72 10.18 106 314027 6469 110268697
Onychomadesis 96.72 10.18 9 314124 45654 110229512
Platelet count decreased 96.01 10.18 334 313799 230109 110045057
Alveolar osteitis 95.21 10.18 51 314082 1034 110274132
Adjustment disorder with depressed mood 94.70 10.18 8 314125 43875 110231291
Grip strength decreased 94.64 10.18 55 314078 80119 110195047
Liver function test increased 94.63 10.18 68 314065 88480 110186686
Asthma-chronic obstructive pulmonary disease overlap syndrome 94.58 10.18 103 314030 6241 110268925
Obesity 93.91 10.18 110 314023 113241 110161925
Mucosal inflammation 93.71 10.18 81 314052 96060 110179106
Electrocardiogram QRS complex prolonged 92.85 10.18 147 313986 12874 110262292
Hyperkalaemia 90.42 10.18 154 313979 135642 110139524
Gastrointestinal haemorrhage 90.21 10.18 211 313922 165307 110109859
Sciatica 88.66 10.18 79 314054 92320 110182846
Stoma site discharge 88.14 10.18 69 314064 2726 110272440
Hyperammonaemia 87.05 10.18 147 313986 13585 110261581
Oedema 86.99 10.18 946 313187 209030 110066136
Mood swings 86.88 10.18 197 313936 22615 110252551
Accidental death 86.58 10.18 88 314045 4921 110270245
Bipolar disorder 86.46 10.18 117 314016 8890 110266276
Cytokine release syndrome 86.21 10.18 46 314087 70260 110204906
Cytomegalovirus infection 85.96 10.18 24 314109 54420 110220746
Abdominal pain upper 85.48 10.18 610 313523 348501 109926665
Mental status changes 85.38 10.18 435 313698 75687 110199479
Derealisation 85.29 10.18 61 314072 2097 110273069
Toxic encephalopathy 84.93 10.18 154 313979 15060 110260106
Exposure via ingestion 84.54 10.18 86 314047 4814 110270352
Lower limb fracture 84.34 10.18 55 314078 75293 110199873
Lupus-like syndrome 83.89 10.18 9 314124 40783 110234383
Cardiac failure 83.62 10.18 264 313869 187362 110087804
Multiple sclerosis relapse 83.60 10.18 323 313810 49917 110225249
Hallucination, visual 83.34 10.18 275 313858 39330 110235836
Angioedema 83.32 10.18 94 314039 98406 110176760
Hypothermia 82.81 10.18 211 313922 26091 110249075
Depersonalisation/derealisation disorder 82.43 10.18 60 314073 2121 110273045
Injury 82.14 10.18 245 313888 177020 110098146
Extrapyramidal disorder 82.14 10.18 223 313910 28644 110246522
Suspected suicide 78.76 10.18 149 313984 15050 110260116
Haematochezia 77.84 10.18 130 314003 115394 110159772
Hypoaesthesia oral 77.59 10.18 158 313975 16844 110258322
Anticonvulsant drug level above therapeutic 77.54 10.18 47 314086 1215 110273951
Drug screen positive 76.88 10.18 93 314040 6317 110268849
Electroencephalogram abnormal 76.39 10.18 91 314042 6082 110269084
Lactic acidosis 75.88 10.18 91 314042 92720 110182446
Ascites 75.88 10.18 91 314042 92717 110182449
Tunnel vision 75.18 10.18 55 314078 1960 110273206
Arthritis 74.54 10.18 236 313897 167350 110107816
Animal scratch 74.52 10.18 53 314080 1806 110273360
Hyperthermia 73.68 10.18 177 313956 21095 110254071
Head injury 73.58 10.18 279 313854 42738 110232428
Knee arthroplasty 73.25 10.18 47 314086 64901 110210265
Bladder pain 73.18 10.18 62 314071 2743 110272423
C-reactive protein 73.10 10.18 3 314130 30328 110244838
Off label use 72.41 10.18 3505 310628 1496680 108778486
Hip arthroplasty 72.22 10.18 34 314099 55779 110219387
Hepatic cirrhosis 72.18 10.18 52 314081 67574 110207592
Septic shock 72.07 10.18 219 313914 157309 110117857
Carpal tunnel syndrome 71.82 10.18 182 313951 22428 110252738
Cognitive disorder 71.15 10.18 459 313674 87052 110188114
Depressed mood 70.66 10.18 351 313782 60458 110214708
Screaming 70.61 10.18 78 314055 4803 110270363
Incontinence 70.54 10.18 150 313983 16485 110258681
Tension 69.77 10.18 79 314054 4999 110270167
COVID-19 69.74 10.18 409 313724 244651 110030515
Colitis 69.07 10.18 115 314018 102208 110172958
Coeliac disease 68.26 10.18 19 314114 43168 110231998
Galactorrhoea 68.21 10.18 71 314062 4084 110271082
Melaena 68.14 10.18 57 314076 68700 110206466
Dystonic tremor 67.74 10.18 29 314104 348 110274818
Burning sensation 67.74 10.18 381 313752 68831 110206335
Wrong patient received product 67.60 10.18 89 314044 6585 110268581
Red blood cell sedimentation rate increased 67.02 10.18 74 314059 78228 110196938
Nystagmus 66.94 10.18 119 314014 11458 110263708
Feeling of body temperature change 66.55 10.18 85 314048 6103 110269063
Bradycardia 66.41 10.18 705 313428 154812 110120354
Victim of crime 66.23 10.18 44 314089 1339 110273827
Sinusitis 65.25 10.18 534 313599 296154 109979012
Bone marrow failure 65.05 10.18 42 314091 57806 110217360
Breast cancer stage II 65.00 10.18 3 314130 27372 110247794
Exposure during pregnancy 64.25 10.18 251 313882 167173 110107993
Stoma site erythema 64.05 10.18 51 314082 2066 110273100
Adverse drug reaction 63.79 10.18 127 314006 105432 110169734
Encephalopathy 63.38 10.18 421 313712 80634 110194532
Colitis ulcerative 63.09 10.18 76 314057 77287 110197879
Neutrophil count decreased 62.87 10.18 158 313975 120783 110154383
Nightmare 62.34 10.18 247 313886 38616 110236550
Hallucinations, mixed 61.79 10.18 98 314035 8595 110266571
Rhabdomyolysis 61.72 10.18 567 313566 119834 110155332
Osmolar gap increased 61.60 10.18 23 314110 187 110274979
Accidental overdose 61.51 10.18 301 313832 51533 110223633
Hostility 61.10 10.18 55 314078 2641 110272525
Atonic seizures 60.86 10.18 39 314094 1115 110274051
Onychomycosis 60.80 10.18 17 314116 38514 110236652
Drug-induced liver injury 60.77 10.18 159 313974 119908 110155258
Intellectual disability 60.57 10.18 48 314085 1931 110273235
Libido increased 59.93 10.18 53 314080 2486 110272680
Abnormal dreams 59.79 10.18 120 314013 12660 110262506
Wheezing 59.68 10.18 1038 313095 254192 110020974
Cerebellar atrophy 59.57 10.18 42 314091 1411 110273755
Drug tolerance decreased 59.49 10.18 5 314128 27535 110247631
Myoclonic epilepsy 59.22 10.18 54 314079 2637 110272529
Hypertonia 58.70 10.18 94 314039 8312 110266854
Major depression 58.64 10.18 107 314026 10514 110264652
Pneumocystis jirovecii pneumonia 58.50 10.18 24 314109 42711 110232455
Sinus tachycardia 58.37 10.18 266 313867 44227 110230939
Rectal haemorrhage 58.16 10.18 162 313971 119671 110155495
Treatment noncompliance 57.00 10.18 379 313754 72611 110202555
Dopamine dysregulation syndrome 56.50 10.18 30 314103 597 110274569
Urinary retention 56.34 10.18 365 313768 69318 110205848
Hypoventilation 55.93 10.18 90 314043 7991 110267175
Feeling jittery 55.91 10.18 127 314006 14595 110260571
Posture abnormal 55.87 10.18 66 314067 4372 110270794
Impaired driving ability 55.54 10.18 79 314054 6291 110268875
Finger deformity 55.29 10.18 13 314120 33079 110242087
Sarcoidosis 55.17 10.18 115 314018 12464 110262702
Menstrual disorder 55.09 10.18 68 314065 4716 110270450
Incoherent 55.02 10.18 91 314042 8267 110266899
Post-traumatic stress disorder 54.87 10.18 80 314053 6516 110268650
Freezing phenomenon 54.79 10.18 51 314082 2558 110272608
Sluggishness 54.75 10.18 86 314047 7481 110267685
Priapism 54.54 10.18 75 314058 5786 110269380
Blood creatinine increased 54.31 10.18 301 313832 182588 110092578
Nephrectomy 54.27 10.18 51 314082 2589 110272577
Vision blurred 54.20 10.18 583 313550 128439 110146727
Multiple organ dysfunction syndrome 54.11 10.18 234 313899 151476 110123690
Loss of personal independence in daily activities 54.09 10.18 658 313475 149362 110125804
Erythema 53.90 10.18 548 313585 290899 109984267
Tubulointerstitial nephritis 53.79 10.18 45 314088 54239 110220927
Respiratory rate decreased 53.66 10.18 77 314056 6181 110268985
Dry mouth 53.59 10.18 340 313793 199608 110075558
Bronchopulmonary aspergillosis 53.46 10.18 10 314123 29853 110245313
Neoplasm progression 53.16 10.18 63 314070 64532 110210634
Renal failure 52.97 10.18 401 313732 226173 110048993
Gastrointestinal procedural complication 52.80 10.18 26 314107 439 110274727
Blepharospasm 52.50 10.18 47 314086 54804 110220362
Musculoskeletal stiffness 52.22 10.18 525 313608 279297 109995869
Dysphoria 52.08 10.18 77 314056 6351 110268815
Product substitution issue 52.03 10.18 164 313969 22897 110252269
Cytopenia 51.99 10.18 11 314122 30105 110245061
Persecutory delusion 51.89 10.18 76 314057 6215 110268951
Rash pruritic 51.85 10.18 127 314006 97942 110177224
Red blood cell sedimentation rate abnormal 51.46 10.18 5 314128 24504 110250662
Therapeutic product ineffective 51.05 10.18 49 314084 2555 110272611
Heart rate increased 51.04 10.18 629 313504 143205 110131961
Hypomagnesaemia 50.63 10.18 58 314075 60312 110214854
Fibromyalgia 50.35 10.18 282 313851 170627 110104539
H1N1 influenza 50.31 10.18 52 314081 2966 110272200
Impulse-control disorder 50.20 10.18 45 314088 2149 110273017
Product use issue 50.13 10.18 605 313528 311090 109964076
Palmar-plantar erythrodysaesthesia syndrome 50.06 10.18 27 314106 40998 110234168
Osteoporosis 50.00 10.18 108 314025 87044 110188122
Housebound 49.94 10.18 25 314108 438 110274728
Neutropenic sepsis 49.58 10.18 13 314120 30733 110244433
Ejection fraction abnormal 49.55 10.18 55 314078 3405 110271761
Areflexia 49.07 10.18 77 314056 6692 110268474
Drug level increased 48.91 10.18 266 313867 47453 110227713
Disinhibition 48.68 10.18 52 314081 3082 110272084
Neuropathy peripheral 48.48 10.18 304 313829 178973 110096193
Antipsychotic drug level increased 48.38 10.18 78 314055 6937 110268229
Sleep-related eating disorder 48.14 10.18 31 314102 894 110274272
Emotional distress 48.01 10.18 253 313880 44594 110230572
Obsessive-compulsive disorder 47.88 10.18 79 314054 7162 110268004
Oromandibular dystonia 47.13 10.18 34 314099 1185 110273981
Aspergillus infection 47.11 10.18 8 314125 25608 110249558
Shock haemorrhagic 46.94 10.18 10 314123 27237 110247929
Intentional product use issue 46.72 10.18 464 313669 247442 110027724
Drug screen negative 46.71 10.18 22 314111 335 110274831
Transplant rejection 46.69 10.18 7 314126 24560 110250606
Acute myeloid leukaemia 46.62 10.18 25 314108 38085 110237081
Upper respiratory tract infection 46.57 10.18 203 313930 131125 110144041
Autonomic nervous system imbalance 46.49 10.18 69 314064 5711 110269455
Proteinuria 46.45 10.18 28 314105 39990 110235176
Abdominal pain 46.39 10.18 1106 313027 511883 109763283
Decorticate posture 46.30 10.18 22 314111 342 110274824
Tumour lysis syndrome 46.05 10.18 15 314118 30786 110244380
Change in seizure presentation 46.01 10.18 29 314104 805 110274361
Breast hyperplasia 45.95 10.18 18 314115 169 110274997
Gait inability 45.84 10.18 215 313918 136161 110139005
Hypercalcaemia 45.84 10.18 39 314094 46618 110228548
Thrombotic microangiopathy 45.74 10.18 13 314120 29136 110246030
Upper gastrointestinal haemorrhage 45.51 10.18 45 314088 50051 110225115
Logorrhoea 45.48 10.18 63 314070 4894 110270272
Stereotypy 45.46 10.18 31 314102 986 110274180
Accidental poisoning 45.39 10.18 45 314088 2442 110272724
Ear congestion 45.31 10.18 54 314079 3611 110271555
Fear 45.23 10.18 157 313976 23036 110252130
Toxicologic test abnormal 45.01 10.18 34 314099 1273 110273893
Disorganised speech 44.73 10.18 51 314082 3252 110271914
Urinary incontinence 44.62 10.18 263 313870 48324 110226842
Blood test abnormal 44.61 10.18 180 313953 28374 110246792
Therapy non-responder 44.49 10.18 263 313870 157044 110118122
Somnambulism 43.87 10.18 71 314062 6334 110268832
Muscle twitching 43.85 10.18 185 313948 29750 110245416
Mutism 43.75 10.18 49 314084 3064 110272102
Brain scan abnormal 43.63 10.18 36 314097 1535 110273631
Exostosis 43.24 10.18 40 314093 45916 110229250
Device interaction 43.14 10.18 27 314106 740 110274426
Drug level above therapeutic 42.94 10.18 99 314034 11489 110263677
Limb injury 42.84 10.18 216 313917 37420 110237746
Panic disorder 42.79 10.18 51 314082 3410 110271756
Coma scale abnormal 42.75 10.18 89 314044 9637 110265529
Rubber sensitivity 42.74 10.18 43 314090 2375 110272791
Anaphylactic shock 42.71 10.18 50 314083 51496 110223670
Hypocalcaemia 42.71 10.18 75 314058 65291 110209875
Anion gap increased 42.57 10.18 57 314076 4287 110270879
Withdrawal arrhythmia 42.49 10.18 13 314120 52 110275114
Myelodysplastic syndrome 42.44 10.18 27 314106 37457 110237709
Dependence 41.90 10.18 45 314088 2684 110272482
Psychogenic seizure 41.72 10.18 42 314091 2322 110272844
Decompression sickness 41.63 10.18 15 314118 109 110275057
Pleurothotonus 41.57 10.18 43 314090 2455 110272711
Poor quality sleep 41.51 10.18 174 313959 27903 110247263
Psychiatric symptom 41.31 10.18 85 314048 9128 110266038
Foot deformity 41.28 10.18 46 314087 48434 110226732
Myocardial stunning 41.25 10.18 20 314113 326 110274840
Drug diversion 41.23 10.18 33 314100 1347 110273819
Stoma site hypergranulation 41.03 10.18 24 314109 580 110274586
Dysstasia 40.90 10.18 194 313939 32792 110242374
Bruxism 40.72 10.18 60 314073 4934 110270232
Cardiac murmur 40.70 10.18 158 313975 24470 110250696
Tachycardia 40.18 10.18 884 313249 225761 110049405
Dyspepsia 40.03 10.18 348 313785 190617 110084549
Partial seizures 39.92 10.18 95 314038 11254 110263912
Paranasal sinus discomfort 39.85 10.18 68 314065 6337 110268829
Creatinine renal clearance decreased 39.71 10.18 7 314126 21808 110253358
Condition aggravated 39.67 10.18 1695 312438 733141 109542025
Libido decreased 39.58 10.18 65 314068 5870 110269296
Self-injurious ideation 39.52 10.18 55 314078 4291 110270875
Osteonecrosis of jaw 39.33 10.18 47 314086 47970 110227196
Brain injury 39.24 10.18 105 314028 13371 110261795
Muscle disorder 39.12 10.18 69 314064 6603 110268563
Cytomegalovirus viraemia 39.00 10.18 3 314130 17761 110257405
Concussion 38.88 10.18 95 314038 11443 110263723
Cardiac failure congestive 38.81 10.18 260 313873 150740 110124426
Prostate cancer 38.80 10.18 30 314103 37611 110237555
Sinus pain 38.69 10.18 64 314069 5815 110269351
Seizure cluster 38.69 10.18 26 314107 807 110274359
Post-traumatic neck syndrome 38.46 10.18 42 314091 2553 110272613
Influenza like illness 38.30 10.18 402 313731 88010 110187156
Broncholithiasis 38.22 10.18 18 314115 274 110274892
Psychotic behaviour 38.21 10.18 32 314101 1393 110273773
Skin ulcer 38.08 10.18 77 314056 63568 110211598
Parasomnia 38.07 10.18 25 314108 746 110274420
Illusion 37.90 10.18 37 314096 1970 110273196
Aplastic anaemia 37.85 10.18 11 314122 24297 110250869
Panic reaction 37.83 10.18 60 314073 5262 110269904
Dysphagia 37.81 10.18 630 313503 152970 110122196
Reduced facial expression 37.46 10.18 49 314084 3602 110271564
Torticollis 37.44 10.18 46 314087 3175 110271991
Developmental delay 37.44 10.18 32 314101 1433 110273733
Myocardial depression 36.79 10.18 24 314109 708 110274458
Anaphylactic reaction 36.79 10.18 183 313950 114117 110161049
Blood prolactin increased 36.74 10.18 55 314078 4587 110270579
Attention deficit hyperactivity disorder 36.68 10.18 54 314079 4437 110270729
Weight abnormal 36.55 10.18 38 314095 2183 110272983
Frequent bowel movements 36.53 10.18 94 314039 71296 110203870
Pathogen resistance 36.08 10.18 4 314129 17668 110257498
Soft tissue injury 35.77 10.18 38 314095 2238 110272928
Bipolar I disorder 35.67 10.18 38 314095 2245 110272921
Patient uncooperative 35.36 10.18 26 314107 934 110274232
Adverse reaction 35.35 10.18 20 314113 29574 110245592
Laryngitis 35.29 10.18 41 314092 42370 110232796
Hepatitis 35.19 10.18 134 313999 89920 110185246
Decreased appetite 35.13 10.18 1056 313077 474790 109800376
Brain oedema 35.06 10.18 178 313955 30920 110244246
Agoraphobia 34.82 10.18 23 314110 693 110274473
Impulsive behaviour 34.81 10.18 45 314088 3270 110271896
Coordination abnormal 34.72 10.18 153 313980 25075 110250091
Hypotonia 34.63 10.18 111 314022 15634 110259532
Adverse event 34.56 10.18 175 313958 108634 110166532
Plasma cell myeloma 34.46 10.18 80 314053 62856 110212310
Secretion discharge 34.37 10.18 131 314002 20113 110255053
Basal cell carcinoma 34.30 10.18 47 314086 45223 110229943
Wrist fracture 33.89 10.18 104 314029 14313 110260853
Cerebral artery thrombosis 33.86 10.18 32 314101 1636 110273530
Gaze palsy 33.84 10.18 45 314088 3362 110271804
Haematotoxicity 33.83 10.18 9 314124 21073 110254093
Ulcer haemorrhage 33.73 10.18 11 314122 22560 110252606
Myocardial infarction 33.53 10.18 366 313767 191717 110083449
Heat stroke 33.46 10.18 34 314099 1901 110273265
Feeling guilty 33.45 10.18 25 314108 921 110274245
Acute myocardial infarction 33.16 10.18 124 314009 83653 110191513
Hyperkinesia 33.09 10.18 43 314090 3141 110272025
Death 33.06 10.18 2357 311776 696512 109578654
Tachyphrenia 32.96 10.18 37 314096 2319 110272847
Parkinsonian gait 32.81 10.18 26 314107 1046 110274120
Substance use 32.77 10.18 38 314095 2468 110272698
Hyperphosphataemia 32.72 10.18 4 314129 16377 110258789
Muscle contracture 32.47 10.18 40 314093 2768 110272398
Food craving 32.47 10.18 34 314099 1969 110273197
Anorgasmia 32.32 10.18 31 314102 1615 110273551
Rapid eye movement sleep behaviour disorder 32.23 10.18 21 314112 618 110274548
Affective disorder 32.14 10.18 87 314046 11154 110264012
Bacteraemia 32.12 10.18 44 314089 42346 110232820
Fluid retention 32.09 10.18 148 313985 94159 110181007
Encephalitis toxic 31.88 10.18 16 314117 282 110274884
Cerebral salt-wasting syndrome 31.82 10.18 16 314117 283 110274883
Apathy 31.73 10.18 110 314023 16129 110259037
Accidental exposure to product by child 31.39 10.18 42 314091 3156 110272010
End stage renal disease 31.16 10.18 11 314122 21462 110253704
Piloerection 30.80 10.18 23 314110 846 110274320
Compartment syndrome 30.70 10.18 58 314075 5852 110269314
Lymph node calcification 30.20 10.18 18 314115 451 110274715
Adrenal insufficiency 30.16 10.18 46 314087 42344 110232822
Maternal exposure timing unspecified 30.09 10.18 11 314122 21002 110254164
Cholestasis 30.00 10.18 89 314044 64429 110210737
Band neutrophil percentage increased 29.97 10.18 17 314116 387 110274779
Adjustment disorder with mixed anxiety and depressed mood 29.97 10.18 12 314121 120 110275046
Epidermal necrosis 29.86 10.18 40 314093 3010 110272156
Stoma site pain 29.49 10.18 32 314101 1931 110273235
Hypotension 29.46 10.18 1793 312340 522056 109753110
Coma blister 29.44 10.18 14 314119 218 110274948
Vessel puncture site erythema 29.20 10.18 6 314127 0 110275166
Cytomegalovirus infection reactivation 29.09 10.18 8 314125 18325 110256841
Euphoric mood 29.03 10.18 72 314061 8755 110266411
Oscillopsia 28.91 10.18 17 314116 415 110274751
Drug detoxification 28.87 10.18 19 314114 569 110274597
Physical assault 28.87 10.18 29 314104 1599 110273567
Nausea 28.85 10.18 3072 311061 1232618 109042548
Hyperreflexia 28.73 10.18 75 314058 9410 110265756
Suicidal behaviour 28.49 10.18 42 314091 3455 110271711
Oculogyric crisis 28.35 10.18 44 314089 3788 110271378
Blood phosphorus increased 28.14 10.18 6 314127 16334 110258832
Bacterial infection 28.14 10.18 55 314078 45981 110229185
Blood sodium decreased 28.14 10.18 196 313937 38123 110237043
Nervous system disorder 28.04 10.18 170 313963 31551 110243615
Thrombosis 27.97 10.18 187 313946 108475 110166691
Oedema peripheral 27.93 10.18 715 313418 327945 109947221
Flat affect 27.87 10.18 35 314098 2470 110272696
Eyelid function disorder 27.77 10.18 18 314115 525 110274641
Oropharyngeal oedema 27.76 10.18 17 314116 448 110274718
Wound complication 27.71 10.18 57 314076 6120 110269046
Myelocyte count increased 27.61 10.18 22 314111 892 110274274
White blood cells urine positive 27.57 10.18 64 314069 7460 110267706
Drop attacks 27.53 10.18 24 314109 1104 110274062
Device dislocation 27.45 10.18 169 313964 31535 110243631
Urinary bladder rupture 27.04 10.18 12 314121 158 110275008
Polyarthritis 27.03 10.18 10 314123 18953 110256213
Blood iron decreased 26.80 10.18 117 314016 19097 110256069
Hyperphagia 26.76 10.18 41 314092 3490 110271676
Rash maculo-papular 26.75 10.18 114 314019 74108 110201058
Asphyxia 26.66 10.18 95 314038 14120 110261046
Bronchiectasis 26.41 10.18 186 313947 36307 110238859
Alcohol abuse 26.39 10.18 49 314084 4880 110270286
Right ventricular failure 26.36 10.18 21 314112 25933 110249233
Testicular infarction 26.30 10.18 9 314124 55 110275111
Acute graft versus host disease 26.09 10.18 3 314130 12878 110262288
Cyanosis 26.04 10.18 159 313974 29582 110245584
Personality disorder 26.00 10.18 88 314045 12749 110262417
Visceral congestion 25.78 10.18 25 314108 1320 110273846
Feeling cold 25.64 10.18 175 313958 33812 110241354
Akinesia 25.60 10.18 41 314092 3626 110271540
Vagal nerve stimulator implantation 25.51 10.18 13 314120 237 110274929
Incorrect dose administered 25.47 10.18 425 313708 103216 110171950
Dysphemia 25.30 10.18 43 314090 3994 110271172
Petit mal epilepsy 25.28 10.18 62 314071 7485 110267681
Substance dependence 25.28 10.18 19 314114 706 110274460
Tonic convulsion 25.16 10.18 37 314096 3037 110272129
Stress 25.16 10.18 430 313703 104918 110170248
Cardiac disorder 25.10 10.18 329 313804 75951 110199215
Postmortem blood drug level abnormal 25.09 10.18 18 314115 622 110274544
Haematemesis 25.05 10.18 85 314048 59023 110216143
Myositis 24.91 10.18 31 314102 31085 110244081
Facial bones fracture 24.85 10.18 48 314085 4923 110270243
Stoma site infection 24.79 10.18 28 314105 1767 110273399
Female genital tract fistula 24.77 10.18 8 314125 16511 110258655
Haemophagocytic lymphohistiocytosis 24.69 10.18 32 314101 31527 110243639
Stupor 24.67 10.18 65 314068 8200 110266966
Squamous cell carcinoma of skin 24.64 10.18 9 314124 17194 110257972
Hypervolaemia 24.64 10.18 66 314067 49394 110225772
Failure to suspend medication 24.58 10.18 16 314117 470 110274696
Memory impairment 24.56 10.18 733 313400 196211 110078955
Cerebral haemorrhage 24.53 10.18 98 314035 64870 110210296
Wound secretion 24.52 10.18 58 314075 6843 110268323
Obsessive thoughts 24.51 10.18 24 314109 1283 110273883
Post transplant lymphoproliferative disorder 24.43 10.18 7 314126 15606 110259560
Dyspnoea exertional 24.39 10.18 184 313949 103876 110171290
BK virus infection 24.31 10.18 4 314129 13102 110262064
Substance-induced psychotic disorder 24.27 10.18 50 314083 5374 110269792
Drug withdrawal maintenance therapy 24.25 10.18 11 314122 153 110275013
Epistaxis 24.14 10.18 245 313888 130127 110145039
Paralysis 24.10 10.18 98 314035 15502 110259664
Respiratory acidosis 23.91 10.18 90 314043 13736 110261430
Hypoxic-ischaemic encephalopathy 23.84 10.18 67 314066 8780 110266386
Polymyalgia rheumatica 23.83 10.18 55 314078 6387 110268779
Joint stiffness 23.80 10.18 104 314029 67139 110208027
Post-anoxic myoclonus 23.79 10.18 8 314125 46 110275120
Paroxysmal perceptual alteration 23.69 10.18 13 314120 277 110274889
Aphasia 23.58 10.18 264 313869 58733 110216433
Dissociative disorder 23.51 10.18 23 314110 1228 110273938
Hypoaesthesia 23.50 10.18 696 313437 313527 109961639
Chronic kidney disease 23.50 10.18 124 314009 76167 110198999
Nephropathy toxic 23.48 10.18 26 314107 27452 110247714
Clonus 23.47 10.18 66 314067 8650 110266516
White blood cell count decreased 23.43 10.18 485 313648 228905 110046261
Pustular psoriasis 23.42 10.18 5 314128 13600 110261566
Gambling disorder 23.41 10.18 30 314103 2161 110273005
Eosinophilic pleural effusion 23.38 10.18 16 314117 512 110274654
Ketosis-prone diabetes mellitus 23.23 10.18 8 314125 50 110275116
Immunodeficiency 23.23 10.18 47 314086 38791 110236375
Schizoaffective disorder 23.19 10.18 36 314097 3100 110272066
Therapeutic response unexpected 23.16 10.18 131 314002 23712 110251454
Sudden unexplained death in epilepsy 23.15 10.18 19 314114 804 110274362
Eczema 23.11 10.18 116 314017 72177 110202989
Haemoptysis 23.10 10.18 114 314019 71240 110203926
Immunosuppressant drug level increased 23.08 10.18 3 314130 11721 110263445
Psychotic disorder due to a general medical condition 23.04 10.18 13 314120 293 110274873
Brain hypoxia 23.03 10.18 23 314110 1259 110273907
Metastases to liver 22.76 10.18 41 314092 35345 110239821
Stoma site extravasation 22.75 10.18 14 314119 372 110274794
Acute generalised exanthematous pustulosis 22.67 10.18 17 314116 21647 110253519
Post cholecystectomy syndrome 22.57 10.18 19 314114 833 110274333
Oesophageal carcinoma 22.57 10.18 3 314130 11521 110263645
Leukopenia 22.33 10.18 293 313840 148498 110126668
Social avoidant behaviour 22.29 10.18 48 314085 5321 110269845
Enuresis 22.28 10.18 41 314092 4055 110271111
Antisocial behaviour 22.26 10.18 19 314114 849 110274317
Brain malformation 22.10 10.18 8 314125 59 110275107
Oral candidiasis 22.09 10.18 60 314073 44700 110230466
Blood bicarbonate decreased 22.00 10.18 50 314083 5747 110269419
Epstein-Barr virus infection 21.90 10.18 13 314120 18725 110256441
Homicidal ideation 21.90 10.18 38 314095 3589 110271577
Staphylococcal bacteraemia 21.84 10.18 10 314123 16678 110258488
Vomiting 21.76 10.18 2928 311205 907747 109367419
Breath sounds abnormal 21.74 10.18 24 314109 25380 110249786
Sternal fracture 21.69 10.18 36 314097 3280 110271886
Sexual abuse 21.69 10.18 12 314121 260 110274906
Intensive care unit acquired weakness 21.67 10.18 30 314103 2329 110272837
Diffuse large B-cell lymphoma 21.64 10.18 9 314124 15889 110259277
Gastrointestinal toxicity 21.60 10.18 3 314130 11145 110264021
Conversion disorder 21.56 10.18 30 314103 2340 110272826
Kidney transplant rejection 21.49 10.18 4 314129 11983 110263183
Hormone level abnormal 21.46 10.18 30 314103 2350 110272816
Haemoglobin urine 21.43 10.18 10 314123 149 110275017
Hypersexuality 21.42 10.18 27 314106 1913 110273253
Sleep talking 21.41 10.18 22 314111 1246 110273920
Disseminated intravascular coagulation 21.40 10.18 54 314079 41232 110233934
Lymphopenia 21.25 10.18 52 314081 40118 110235048
Amylase increased 21.24 10.18 81 314052 12438 110262728
Gout 21.23 10.18 45 314088 36521 110238645
Hyponatraemia 21.12 10.18 464 313669 217189 110057977
Pollakiuria 21.08 10.18 205 313928 43990 110231176
Gangrene 21.07 10.18 10 314123 16331 110258835
Choreoathetosis 20.96 10.18 25 314108 1673 110273493
Postoperative respiratory failure 20.94 10.18 11 314122 214 110274952
Bladder dilatation 20.90 10.18 30 314103 2409 110272757
Communication disorder 20.86 10.18 45 314088 4994 110270172
Proctitis 20.86 10.18 11 314122 16916 110258250
CADASIL 20.85 10.18 7 314126 40 110275126
Trismus 20.85 10.18 53 314080 6543 110268623
Sebaceous gland infection 20.85 10.18 10 314123 159 110275007
Neutrophil count increased 20.79 10.18 169 313964 34483 110240683
Dementia with Lewy bodies 20.79 10.18 20 314113 1046 110274120
Hyperammonaemic encephalopathy 20.77 10.18 47 314086 5387 110269779
Blood osmolarity increased 20.74 10.18 18 314115 823 110274343
Coronary artery disease 20.72 10.18 119 314014 71571 110203595
Hypomania 20.68 10.18 70 314063 10140 110265026
Generalised anxiety disorder 20.68 10.18 32 314101 2747 110272419
Formication 20.65 10.18 48 314085 5600 110269566
Pregnancy 20.59 10.18 75 314058 50992 110224174
Onychophagia 20.52 10.18 9 314124 115 110275051
Confusional state 20.48 10.18 1571 312562 467109 109808057
Pulmonary hypertension 20.41 10.18 84 314049 55136 110220030
Laboratory test abnormal 20.35 10.18 61 314072 44018 110231148
Blood osmolarity decreased 20.32 10.18 23 314110 1455 110273711
Facial paralysis 20.29 10.18 128 314005 24086 110251080
Hereditary angioedema 20.28 10.18 55 314078 7059 110268107
Contusion 20.27 10.18 506 313627 232855 110042311
Compulsive shopping 20.25 10.18 18 314115 850 110274316
Drug eruption 20.22 10.18 81 314052 53578 110221588
Back injury 20.20 10.18 68 314065 47331 110227835
Metastases to central nervous system 20.15 10.18 21 314112 22796 110252370
Psychotic symptom 20.15 10.18 38 314095 3829 110271337
Venoocclusive liver disease 20.08 10.18 9 314124 15198 110259968
Hyperarousal 20.03 10.18 7 314126 46 110275120
Tongue discolouration 19.91 10.18 39 314094 4042 110271124
Peroneal nerve palsy 19.83 10.18 56 314077 7358 110267808
Pulmonary arterial hypertension 19.83 10.18 39 314094 32529 110242637
Obsessive-compulsive personality disorder 19.66 10.18 9 314124 128 110275038
Magnetic resonance imaging abnormal 19.61 10.18 38 314095 3907 110271259
Cholangitis 19.57 10.18 11 314122 16324 110258842
Ehlers-Danlos syndrome 19.50 10.18 12 314121 319 110274847
Vertigo 19.46 10.18 351 313782 86519 110188647
Stoma site inflammation 19.40 10.18 19 314114 1016 110274150
Anticonvulsant drug level decreased 19.38 10.18 27 314106 2109 110273057
Poverty of speech 19.31 10.18 15 314118 586 110274580
Amnesia 19.26 10.18 413 313720 104995 110170171
Increased appetite 19.24 10.18 89 314044 14888 110260278
Hypophosphataemia 19.13 10.18 41 314092 33141 110242025
Blood creatine phosphokinase 19.11 10.18 12 314121 331 110274835
Eye movement disorder 19.10 10.18 66 314067 9662 110265504
Blood loss anaemia 19.05 10.18 14 314119 18011 110257155
Tic 19.04 10.18 35 314098 3458 110271708
Excessive eye blinking 19.04 10.18 25 314108 1845 110273321
Walking aid user 19.03 10.18 26 314107 25049 110250117
Abulia 19.02 10.18 21 314112 1292 110273874
Social problem 18.99 10.18 25 314108 1849 110273317
Congenital inguinal hernia 18.87 10.18 5 314128 10 110275156
Diverticulitis 18.80 10.18 83 314050 53439 110221727
Transfusion 18.74 10.18 27 314106 25445 110249721
Cluster headache 18.70 10.18 20 314113 1187 110273979
Anticonvulsant drug level increased 18.66 10.18 31 314102 2827 110272339
Sleep disorder 18.55 10.18 426 313707 198218 110076948
Cardiac failure chronic 18.51 10.18 8 314125 13803 110261363
Head titubation 18.46 10.18 21 314112 1336 110273830
Dry skin 18.43 10.18 206 313927 107447 110167719
Aspiration 18.37 10.18 149 313984 30384 110244782
Learning disorder 18.35 10.18 16 314117 736 110274430
Drug screen false positive 18.31 10.18 21 314112 1348 110273818
Cerebral atrophy 18.15 10.18 62 314071 9023 110266143
Haematuria traumatic 18.13 10.18 12 314121 363 110274803
Mucormycosis 18.11 10.18 4 314129 10624 110264542
Suspiciousness 18.08 10.18 16 314117 751 110274415
Cerebrovascular accident 18.01 10.18 385 313748 180899 110094267
Dysmorphism 17.99 10.18 15 314118 649 110274517
HIV peripheral neuropathy 17.91 10.18 6 314127 34 110275132
Product use in unapproved indication 17.89 10.18 1064 313069 446313 109828853
Temperature regulation disorder 17.89 10.18 7 314126 12819 110262347
Staphylococcal sepsis 17.88 10.18 14 314119 17440 110257726
Dysuria 17.87 10.18 255 313878 59976 110215190
Vitamin B12 deficiency 17.85 10.18 66 314067 9989 110265177
Jaundice 17.84 10.18 97 314036 59139 110216027
Affect lability 17.84 10.18 102 314031 18535 110256631
Focal dyscognitive seizures 17.84 10.18 36 314097 3813 110271353
Vasculitis 17.77 10.18 48 314085 35825 110239341
Niemann-Pick disease 17.77 10.18 6 314127 35 110275131
Disability 17.71 10.18 37 314096 30186 110244980
Infantile spasms 17.67 10.18 12 314121 379 110274787
Hypoacusis 17.66 10.18 165 313968 35026 110240140
Phaeochromocytoma malignant 17.66 10.18 7 314126 68 110275098
Myelocyte percentage increased 17.66 10.18 10 314123 227 110274939
Immune effector cell-associated neurotoxicity syndrome 17.64 10.18 10 314123 14772 110260394
Essential tremor 17.63 10.18 24 314109 1834 110273332
Pericardial effusion 17.62 10.18 93 314040 57124 110218042
Atrial flutter 17.58 10.18 26 314107 24236 110250930
Anticonvulsant drug level below therapeutic 17.56 10.18 19 314114 1143 110274023
Parotid gland enlargement 17.52 10.18 19 314114 1146 110274020
Sickle cell anaemia with crisis 17.51 10.18 3 314130 9542 110265624
Clonic convulsion 17.46 10.18 22 314111 1558 110273608
Tinnitus 17.44 10.18 255 313878 60285 110214881
COVID-19 pneumonia 17.44 10.18 51 314082 37092 110238074
Parkinsonian rest tremor 17.42 10.18 12 314121 388 110274778
Hyperchloraemia 17.41 10.18 20 314113 1286 110273880
Erectile dysfunction 17.40 10.18 101 314032 18455 110256711
Choking 17.39 10.18 87 314046 15023 110260143
Renal disorder 17.38 10.18 216 313917 49263 110225903
Mouth ulceration 17.31 10.18 74 314059 48064 110227102
Pulmonary alveolar haemorrhage 17.29 10.18 19 314114 20131 110255035
Dysgraphia 17.22 10.18 40 314093 4665 110270501
Vitamin B12 increased 17.20 10.18 25 314108 2030 110273136
Skin toxicity 17.16 10.18 6 314127 11777 110263389
Haemoglobin decreased 17.11 10.18 557 313576 248170 110026996
Infusion site reaction 17.10 10.18 15 314118 17667 110257499
Haematuria 17.06 10.18 152 313981 82853 110192313
Nephrotic syndrome 17.03 10.18 9 314124 13822 110261344
Band neutrophil count increased 17.02 10.18 15 314118 700 110274466
Dermatitis exfoliative generalised 17.02 10.18 5 314128 10967 110264199
Allodynia 16.94 10.18 25 314108 2058 110273108
Ulcer 16.94 10.18 64 314069 43052 110232114
Heart rate abnormal 16.81 10.18 52 314081 7186 110267980
Skin laceration 16.81 10.18 158 313975 33595 110241571
Initial insomnia 16.64 10.18 66 314067 10323 110264843
Oxygen saturation decreased 16.63 10.18 573 313560 156409 110118757
Clinomania 16.58 10.18 7 314126 81 110275085
Conduction disorder 16.54 10.18 36 314097 4019 110271147
Hypoalbuminaemia 16.54 10.18 36 314097 28938 110246228
Urticaria thermal 16.51 10.18 13 314120 518 110274648
Systemic candida 16.50 10.18 4 314129 9970 110265196
Cystitis haemorrhagic 16.48 10.18 7 314126 12202 110262964
Illness anxiety disorder 16.45 10.18 10 314123 260 110274906
Electric shock 16.42 10.18 23 314110 1805 110273361
Administration site erythema 16.42 10.18 12 314121 427 110274739
Autoimmune hepatitis 16.30 10.18 11 314122 14793 110260373
Rib fracture 16.28 10.18 157 313976 33613 110241553
Pneumonitis 16.24 10.18 139 313994 76392 110198774
Paradoxical drug reaction 16.23 10.18 63 314070 9754 110265412
Sinus disorder 16.20 10.18 153 313980 32575 110242591
Cytotoxic oedema 16.18 10.18 12 314121 437 110274729
Alcohol use 16.14 10.18 36 314097 4086 110271080
Delirium 16.14 10.18 500 313633 134525 110140641
PO2 increased 16.12 10.18 21 314112 1538 110273628
Cerebral infarction 16.11 10.18 84 314049 51754 110223412
Hypogammaglobulinaemia 16.07 10.18 20 314113 20056 110255110
Blood urine present 16.07 10.18 121 314012 24124 110251042
Subarachnoid haemorrhage 16.06 10.18 38 314095 29664 110245502
Product monitoring error 15.96 10.18 3 314130 8924 110266242
Bedridden 15.95 10.18 78 314055 13347 110261819
Physical abuse 15.94 10.18 6 314127 50 110275116
Product administration interrupted 15.93 10.18 69 314064 11223 110263943
Macular degeneration 15.90 10.18 23 314110 21636 110253530
Distractibility 15.89 10.18 16 314117 885 110274281
Escherichia infection 15.85 10.18 27 314106 23789 110251377
Graft versus host disease 15.84 10.18 18 314115 18788 110256378
Congenital muscle absence 15.79 10.18 5 314128 23 110275143
Staphylococcal infection 15.77 10.18 125 314008 69819 110205347
Sensorimotor disorder 15.71 10.18 18 314115 1154 110274012
Drug dose omission by device 15.70 10.18 11 314122 14505 110260661
Hypertransaminasaemia 15.69 10.18 28 314105 24227 110250939
Myasthenia gravis 15.63 10.18 23 314110 21488 110253678
Jealous delusion 15.62 10.18 12 314121 461 110274705
Pneumonia 15.60 10.18 2773 311360 873941 109401225
Toxic epidermal necrolysis 15.58 10.18 237 313896 56490 110218676
Language disorder 15.58 10.18 34 314099 3804 110271362
Sensitivity to weather change 15.49 10.18 63 314070 9965 110265201
Lip and/or oral cavity cancer 15.48 10.18 18 314115 1172 110273994
Injection site reaction 15.42 10.18 170 313963 88900 110186266
Escherichia sepsis 15.36 10.18 5 314128 10267 110264899
Cushingoid 15.36 10.18 7 314126 11705 110263461
Clostridium difficile infection 15.35 10.18 86 314047 52043 110223123
Normal newborn 15.35 10.18 24 314109 21872 110253294
Herpes zoster 15.33 10.18 216 313917 108163 110167003
Ventricular pre-excitation 15.28 10.18 5 314128 26 110275140
Electrocardiogram QRS complex shortened 15.27 10.18 15 314118 805 110274361
Calculus urinary 15.23 10.18 30 314103 3122 110272044
Alcoholism 15.23 10.18 33 314100 3674 110271492
Joint destruction 15.22 10.18 6 314127 10937 110264229
Euglycaemic diabetic ketoacidosis 15.16 10.18 7 314126 11616 110263550
Sexual dysfunction 15.15 10.18 56 314077 8474 110266692
Neutrophil percentage increased 15.04 10.18 39 314094 4874 110270292
Decubitus ulcer 15.03 10.18 96 314037 18140 110257026
Lumbar hernia 15.03 10.18 8 314125 160 110275006
Social anxiety disorder 14.96 10.18 16 314117 950 110274216
Pneumonia fungal 14.90 10.18 12 314121 14742 110260424
Antidepressant drug level increased 14.82 10.18 13 314120 603 110274563
Body temperature increased 14.80 10.18 228 313905 54485 110220681
Clumsiness 14.79 10.18 33 314100 3747 110271419
Metastases to bone 14.78 10.18 43 314090 31329 110243837
Heparin-induced thrombocytopenia 14.72 10.18 7 314126 11417 110263749
Inappropriate affect 14.71 10.18 21 314112 1678 110273488
Keratosis follicular 14.69 10.18 5 314128 30 110275136
Pneumonia bacterial 14.68 10.18 33 314100 26228 110248938
Angina pectoris 14.67 10.18 110 314023 62185 110212981
Paraesthesia 14.63 10.18 639 313494 275882 109999284
Chronic obstructive pulmonary disease 14.62 10.18 410 313723 108748 110166418
Mitochondrial encephalomyopathy 14.61 10.18 7 314126 111 110275055
Metabolic syndrome 14.61 10.18 30 314103 3217 110271949
Binge eating 14.57 10.18 13 314120 617 110274549
Forced expiratory volume decreased 14.56 10.18 75 314058 13101 110262065
Ammonia abnormal 14.56 10.18 10 314123 322 110274844
Parosmia 14.55 10.18 75 314058 13105 110262061
SARS-CoV-2 test positive 14.49 10.18 16 314117 16919 110258247
Anhedonia 14.48 10.18 84 314049 15344 110259822
Premature labour 14.47 10.18 58 314075 9114 110266052
Temperature intolerance 14.45 10.18 78 314055 13872 110261294
Product complaint 14.39 10.18 78 314055 13894 110261272
Antidepressant drug level above therapeutic 14.38 10.18 14 314119 743 110274423
Asthenia 14.30 10.18 1726 312407 687273 109587893
Graft versus host disease in skin 14.28 10.18 3 314130 8251 110266915
Lower gastrointestinal haemorrhage 14.20 10.18 19 314114 18467 110256699
Eyelid injury 14.19 10.18 8 314125 180 110274986
Feeling drunk 14.18 10.18 41 314092 5459 110269707
Haemorrhage intracranial 14.17 10.18 39 314094 28930 110246236
Soliloquy 14.15 10.18 16 314117 1011 110274155
Cholecystitis chronic 14.14 10.18 59 314074 9441 110265725
Blunted affect 14.10 10.18 12 314121 534 110274632
Renal hypertension 14.02 10.18 9 314124 258 110274908
Abnormal sleep-related event 14.02 10.18 15 314118 891 110274275
Psoriasis 13.99 10.18 297 313836 139696 110135470
Locomotive syndrome 13.96 10.18 4 314129 12 110275154
Persistent depressive disorder 13.89 10.18 19 314114 1458 110273708
Pulmonary toxicity 13.87 10.18 18 314115 17728 110257438
Sleep paralysis 13.85 10.18 15 314118 903 110274263
Barotrauma 13.80 10.18 8 314125 190 110274976
Acute coronary syndrome 13.79 10.18 28 314105 23084 110252082
Urosepsis 13.77 10.18 43 314090 30632 110244534
Metastases to lung 13.71 10.18 28 314105 23035 110252131
International normalised ratio increased 13.71 10.18 169 313964 86603 110188563
Candida infection 13.71 10.18 80 314053 47929 110227237
Drug ineffective for unapproved indication 13.70 10.18 386 313747 102452 110172714
Purpura fulminans 13.70 10.18 10 314123 355 110274811
Troponin increased 13.68 10.18 137 313996 29629 110245537
Hypokalaemia 13.66 10.18 404 313729 182044 110093122
Homeless 13.62 10.18 7 314126 130 110275036
Respiratory dyskinesia 13.59 10.18 6 314127 78 110275088
Sputum discoloured 13.51 10.18 130 314003 27815 110247351
Bladder cancer 13.51 10.18 23 314110 20269 110254897
Flight of ideas 13.50 10.18 14 314119 802 110274364
Rash vesicular 13.49 10.18 13 314120 14639 110260527
Illness 13.46 10.18 317 313816 81854 110193312
Pre-existing condition improved 13.45 10.18 45 314088 6481 110268685
Glossopharyngeal nerve disorder 13.35 10.18 5 314128 41 110275125
Adjustment disorder 13.32 10.18 7 314126 10788 110264378
Violence-related symptom 13.31 10.18 15 314118 944 110274222
Metamyelocyte count increased 13.30 10.18 13 314120 693 110274473
Eye pruritus 13.30 10.18 48 314085 32727 110242439
Helplessness 13.29 10.18 10 314123 372 110274794
Mixed liver injury 13.27 10.18 9 314124 12070 110263096
Polydipsia 13.26 10.18 50 314083 7638 110267528
Cataract 13.25 10.18 153 313980 79332 110195834
Paraesthesia oral 13.22 10.18 50 314083 33621 110241545
Acute graft versus host disease in skin 13.20 10.18 7 314126 10733 110264433
Fibrous histiocytoma 13.17 10.18 14 314119 825 110274341
Dysmetria 13.17 10.18 18 314115 1381 110273785
Personal relationship issue 13.16 10.18 8 314125 208 110274958
Anticholinergic syndrome 13.12 10.18 34 314099 4246 110270920
Impaired self-care 13.12 10.18 25 314108 2539 110272627
Intelligence test abnormal 13.07 10.18 4 314129 16 110275150
Optic nerve operation 13.05 10.18 11 314122 483 110274683
Full blood count decreased 13.04 10.18 47 314086 32052 110243114
Panniculitis 13.03 10.18 15 314118 15567 110259599
Pulmonary congestion 13.03 10.18 140 313993 30826 110244340
Pneumatosis intestinalis 13.02 10.18 4 314129 8525 110266641
Hip fracture 13.02 10.18 155 313978 34996 110240170
Electrocardiogram QT shortened 13.01 10.18 9 314124 293 110274873
Drug dependence, antepartum 13.00 10.18 6 314127 87 110275079
Self-destructive behaviour 12.95 10.18 14 314119 841 110274325
Polyneuropathy 12.92 10.18 47 314086 31965 110243201
Skin necrosis 12.89 10.18 26 314107 21486 110253680
Thyroid atrophy 12.88 10.18 9 314124 298 110274868
Hyperventilation 12.88 10.18 55 314078 8892 110266274
Self-medication 12.87 10.18 43 314090 6189 110268977
Precocious puberty 12.86 10.18 10 314123 391 110274775
Asterixis 12.84 10.18 28 314105 3130 110272036
Methaemoglobinaemia 12.79 10.18 5 314128 9163 110266003
Urine oxalate increased 12.76 10.18 8 314125 220 110274946
Aortic stenosis 12.72 10.18 11 314122 13048 110262118
Hepatic cancer 12.68 10.18 8 314125 11148 110264018
Sleep attacks 12.66 10.18 8 314125 223 110274943
Apnoea 12.63 10.18 74 314059 13565 110261601
Chemical burn of gastrointestinal tract 12.53 10.18 3 314130 3 110275163
Antimitochondrial antibody 12.53 10.18 3 314130 3 110275163
Cataplexy 12.48 10.18 16 314117 1153 110274013
Snoring 12.44 10.18 45 314088 6739 110268427
Pupillary reflex impaired 12.42 10.18 32 314101 3983 110271183
Nodal rhythm 12.42 10.18 29 314104 3394 110271772
Blood pressure decreased 12.41 10.18 421 313712 114670 110160496
Uveitis 12.37 10.18 27 314106 21683 110253483
Periorbital haemorrhage 12.30 10.18 9 314124 321 110274845
Gastrointestinal hypomotility 12.27 10.18 24 314109 2484 110272682
Granulocyte count increased 12.27 10.18 21 314112 1962 110273204
Erythema multiforme 12.22 10.18 26 314107 21071 110254095
Lymphocyte percentage decreased 12.20 10.18 38 314095 5272 110269894
Hypnopompic hallucination 12.15 10.18 6 314127 102 110275064
Enterocolitis 12.14 10.18 22 314111 18927 110256239
Hyperuricaemia 12.14 10.18 14 314119 14517 110260649
Laryngomalacia 12.04 10.18 4 314129 22 110275144
Negativism 12.00 10.18 14 314119 915 110274251
Dermatitis acneiform 12.00 10.18 11 314122 12684 110262482
Immune-mediated enterocolitis 12.00 10.18 7 314126 10178 110264988
Postmortem blood drug level increased 11.97 10.18 16 314117 1201 110273965
Left ventricular dysfunction 11.97 10.18 31 314102 23462 110251704
Somatic symptom disorder of pregnancy 11.94 10.18 6 314127 106 110275060
Self esteem decreased 11.91 10.18 15 314118 1062 110274104
Hyperglycaemia 11.89 10.18 170 313963 84920 110190246
Pain in extremity 11.84 10.18 1207 312926 485911 109789255
Encephalitis autoimmune 11.84 10.18 29 314104 3499 110271667
Purpura 11.81 10.18 33 314100 24355 110250811
Eye pain 11.78 10.18 204 313929 49895 110225271
Medical device site erosion 11.75 10.18 5 314128 59 110275107
Dissociative identity disorder 11.75 10.18 5 314128 59 110275107
Somatic symptom disorder 11.72 10.18 27 314106 3132 110272034
Therapy interrupted 11.72 10.18 88 314045 49734 110225432
Lip swelling 11.68 10.18 90 314043 50577 110224589
Cardiac tamponade 11.67 10.18 9 314124 11298 110263868
Pneumothorax 11.63 10.18 56 314077 35229 110239937
Tooth injury 11.61 10.18 22 314111 2224 110272942
Organising pneumonia 11.60 10.18 14 314119 14229 110260937
Gastric ulcer 11.57 10.18 66 314067 39761 110235405
Second primary malignancy 11.56 10.18 21 314112 18047 110257119
Peripheral pulse decreased 11.53 10.18 5 314128 62 110275104
Infected bite 11.50 10.18 21 314112 2064 110273102
Bulbar palsy 11.49 10.18 9 314124 356 110274810
Injection site swelling 11.48 10.18 116 314017 61674 110213492
Ejaculation disorder 11.47 10.18 11 314122 573 110274593
Oral pain 11.45 10.18 61 314072 37383 110237783
Febrile bone marrow aplasia 11.44 10.18 20 314113 17445 110257721
Mucosal erosion 11.44 10.18 25 314108 2799 110272367
Chronic sinusitis 11.37 10.18 35 314098 25049 110250117
Intracranial pressure increased 11.37 10.18 8 314125 10527 110264639
Delusion of replacement 11.37 10.18 8 314125 268 110274898
Congenital knee deformity 11.35 10.18 4 314129 27 110275139
Duodenal ulcer 11.34 10.18 24 314109 19490 110255676
Gambling 11.34 10.18 9 314124 363 110274803
Potentiating drug interaction 11.33 10.18 64 314069 11579 110263587
Plasma cell myeloma recurrent 11.31 10.18 3 314130 7039 110268127
Hallucination, olfactory 11.31 10.18 11 314122 583 110274583
Abscess 11.30 10.18 40 314093 27429 110247737
Narcotic bowel syndrome 11.29 10.18 8 314125 271 110274895
Cerebral arteriosclerosis 11.28 10.18 13 314120 839 110274327
Neuropsychiatric symptoms 11.27 10.18 16 314117 1272 110273894
Somatic delusion 11.27 10.18 12 314121 709 110274457
Rapid eye movements sleep abnormal 11.26 10.18 8 314125 272 110274894
Monocyte percentage increased 11.23 10.18 22 314111 2281 110272885
Partial seizures with secondary generalisation 11.19 10.18 13 314120 846 110274320
Thrombocytosis 11.18 10.18 8 314125 10436 110264730
Radial nerve palsy 11.18 10.18 10 314123 476 110274690
Pulmonary tuberculosis 11.17 10.18 6 314127 9133 110266033
Activation syndrome 11.17 10.18 9 314124 371 110274795
Drug specific antibody present 11.12 10.18 5 314128 8429 110266737
Underdose 11.12 10.18 121 314012 63433 110211733
Fatigue 11.12 10.18 3182 310951 1212776 109062390
Hyperbilirubinaemia 11.12 10.18 47 314086 30624 110244542
Intervertebral disc protrusion 11.09 10.18 124 314009 27574 110247592
Antisocial personality disorder 11.06 10.18 5 314128 69 110275097
High density lipoprotein increased 11.05 10.18 17 314116 1452 110273714
Poor feeding infant 11.05 10.18 7 314126 196 110274970
Device difficult to use 11.04 10.18 23 314110 18782 110256384
Opsoclonus myoclonus 11.01 10.18 8 314125 282 110274884
Stoma site pruritus 11.01 10.18 3 314130 7 110275159
Pseudomonal sepsis 10.97 10.18 6 314127 9040 110266126
Device malfunction 10.96 10.18 116 314017 25442 110249724
Sinus bradycardia 10.92 10.18 130 314003 29353 110245813
Incision site erythema 10.90 10.18 11 314122 610 110274556
Postictal paralysis 10.90 10.18 11 314122 610 110274556
Joint dislocation 10.85 10.18 55 314078 34135 110241031
Volvulus 10.84 10.18 28 314105 3490 110271676
Bronchopulmonary aspergillosis allergic 10.77 10.18 50 314083 8376 110266790
Flank pain 10.68 10.18 32 314101 23098 110252068
Escherichia bacteraemia 10.61 10.18 8 314125 10156 110265010
Intracranial aneurysm 10.61 10.18 35 314098 5005 110270161
Anxiety disorder 10.61 10.18 35 314098 5005 110270161
Poisoning deliberate 10.60 10.18 118 314015 26213 110248953
Deformity 10.60 10.18 8 314125 10152 110265014
Confabulation 10.59 10.18 10 314123 511 110274655
Ammonia increased 10.58 10.18 49 314084 8201 110266965
Endophthalmitis 10.57 10.18 5 314128 8182 110266984
Anhidrosis 10.57 10.18 9 314124 401 110274765
Product dose omission in error 10.52 10.18 33 314100 23479 110251687
Arterial occlusive disease 10.52 10.18 17 314116 15291 110259875
Upper limb fracture 10.51 10.18 98 314035 20790 110254376
Iron deficiency 10.51 10.18 23 314110 18453 110256713
Neglect of personal appearance 10.49 10.18 9 314124 405 110274761
Scrotal infection 10.49 10.18 12 314121 768 110274398
Respiratory distress 10.46 10.18 263 313870 68611 110206555
Chronic graft versus host disease 10.45 10.18 7 314126 9450 110265716
Patella fracture 10.43 10.18 22 314111 2404 110272762
Epilepsy 10.41 10.18 365 313768 99844 110175322
Circadian rhythm sleep disorder 10.40 10.18 14 314119 1058 110274108
Eosinophil count abnormal 10.38 10.18 14 314119 1060 110274106
Lung neoplasm 10.38 10.18 48 314085 8028 110267138
Embolism 10.36 10.18 19 314114 16270 110258896
Nephrogenic diabetes insipidus 10.31 10.18 22 314111 2423 110272743
Postmortem blood drug level 10.31 10.18 8 314125 312 110274854
Cerebellar ataxia 10.24 10.18 20 314113 2068 110273098
Chorea 10.23 10.18 26 314107 3209 110271957
Red blood cells urine 10.23 10.18 11 314122 657 110274509
Blood immunoglobulin A increased 10.22 10.18 17 314116 1551 110273615
Hepatotoxicity 10.20 10.18 244 313889 63156 110212010
Cerebral congestion 10.20 10.18 7 314126 225 110274941
Breast cancer 10.19 10.18 160 313973 38382 110236784

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Tricuspid valve incompetence 30.49 27.20 12 372 96 113473

Pharmacologic Action:

SourceCodeDescription
ATC N03AE01 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Benzodiazepine derivatives
FDA CS M0002356 Benzodiazepines
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:50268 GABA modulator
MeSH PA D000927 Anticonvulsants
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
FDA EPC N0000175694 Benzodiazepine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Myoclonic seizure indication 37356005
Atonic seizure indication 42365007
Absence seizure indication 79631006
Lennox-Gastaut syndrome indication 230418006
Panic disorder indication 371631005 DOID:594
Akathisia off-label use 285145004
Manic Bipolar Disorder Adjunct Treatment off-label use
Suicidal thoughts contraindication 6471006
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Hepatic failure contraindication 59927004
Substance abuse contraindication 66214007
Sleep apnea contraindication 73430006 DOID:0050847
Decreased respiratory function contraindication 80954004
Open-angle glaucoma contraindication 84494001 DOID:1067
Kidney disease contraindication 90708001 DOID:557
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Syncope contraindication 271594007
Pregnancy, function contraindication 289908002
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.65 acidic
pKa2 1.65 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 8.07 WOMBAT-PK CHEMBL
GABA-A receptor; anion channel Ion channel Ki 9.07 CHEMBL
GABA-A receptor; anion channel Ion channel IC50 8.77 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 9.07 CHEMBL

External reference:

IDSource
4017791 VUID
N0000146152 NUI
D00280 KEGG_DRUG
202585 RXNORM
C0009011 UMLSCUI
CHEBI:3756 CHEBI
CHEMBL452 ChEMBL_ID
DB01068 DRUGBANK_ID
D002998 MESH_DESCRIPTOR_UI
2802 PUBCHEM_CID
6963 IUPHAR_LIGAND_ID
2765 INN_ID
5PE9FDE8GB UNII
1345 MMSL
377 MMSL
4477 MMSL
d00197 MMSL
001635 NDDF
387383007 SNOMEDCT_US
69708003 SNOMEDCT_US
4017791 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-0832 TABLET 0.50 mg ORAL ANDA 18 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3212 TABLET 1 mg ORAL ANDA 18 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3213 TABLET 2 mg ORAL ANDA 18 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9290 TABLET, ORALLY DISINTEGRATING 0.13 mg ORAL ANDA 25 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9291 TABLET, ORALLY DISINTEGRATING 0.25 mg ORAL ANDA 25 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9292 TABLET, ORALLY DISINTEGRATING 0.50 mg ORAL ANDA 25 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9293 TABLET, ORALLY DISINTEGRATING 1 mg ORAL ANDA 25 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9294 TABLET, ORALLY DISINTEGRATING 2 mg ORAL ANDA 25 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0904-7227 TABLET 0.50 mg ORAL ANDA 29 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0904-7728 TABLET 1 mg ORAL ANDA 29 sections
CLONAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 16590-058 TABLET 0.50 mg ORAL ANDA 23 sections
CLONAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 16590-059 TABLET 1 mg ORAL ANDA 23 sections
CLONAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 16590-481 TABLET 2 mg ORAL ANDA 23 sections
KLONOPIN HUMAN PRESCRIPTION DRUG LABEL 1 16590-693 TABLET 0.50 mg ORAL NDA 25 sections
KLONOPIN HUMAN PRESCRIPTION DRUG LABEL 1 16590-935 TABLET 1 mg ORAL NDA 26 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 16729-136 TABLET 0.50 mg ORAL ANDA 26 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 16729-137 TABLET 1 mg ORAL ANDA 26 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 16729-138 TABLET 2 mg ORAL ANDA 26 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 17856-0133 TABLET 0.50 mg ORAL ANDA 26 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 17856-0834 TABLET 2 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 17856-0835 TABLET 1 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 17856-3003 TABLET 0.50 mg ORAL ANDA 24 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 21695-260 TABLET 0.50 mg ORAL ANDA 28 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 21695-261 TABLET 1 mg ORAL ANDA 28 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 21695-262 TABLET 2 mg ORAL ANDA 28 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 33261-029 TABLET 1 mg ORAL ANDA 30 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 33261-340 TABLET 0.50 mg ORAL ANDA 30 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 33261-628 TABLET 2 mg ORAL ANDA 30 sections
CLONAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 42549-534 TABLET 1 mg ORAL ANDA 30 sections
CLONAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 42549-608 TABLET 1 mg ORAL ANDA 23 sections