clonazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 703 1622-61-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clonazepam
  • lonazep
  • klonopin
An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
  • Molecular weight: 315.71
  • Formula: C15H10ClN3O3
  • CLOGP: 2.38
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 87.28
  • ALOGS: -4.47
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
8 mg O
8 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.42 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 98 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.90 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.88 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.15 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 38 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
June 4, 1975 FDA ROCHE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2309.21 10.00 2572 192495 131261 55965739
Toxicity to various agents 862.45 10.00 2193 192874 222371 55874629
Suicide attempt 705.30 10.00 934 194133 56902 56040098
Rheumatoid arthritis 689.03 10.00 234 194833 382370 55714630
Drug abuse 618.33 10.00 952 194115 66658 56030342
Contraindicated product administered 530.65 10.00 28 195039 186258 55910742
Anxiety 525.03 10.00 1666 193401 191506 55905494
Intentional overdose 498.05 10.00 867 194200 67250 56029750
Synovitis 486.87 10.00 16 195051 161289 55935711
Suicidal ideation 480.80 10.00 779 194288 56963 56040037
Respiratory arrest 441.91 10.00 538 194529 30087 56066913
Seizure 437.44 10.00 1181 193886 123938 55973062
Depression 436.09 10.00 1494 193573 178623 55918377
Systemic lupus erythematosus 417.37 10.00 63 195004 180015 55916985
Somnolence 398.60 10.00 1359 193708 162054 55934946
Hand deformity 377.39 10.00 22 195045 134470 55962530
Cardio-respiratory arrest 363.20 10.00 672 194395 54649 56042351
Glossodynia 356.33 10.00 52 195015 152406 55944594
Drug intolerance 352.94 10.00 243 194824 264575 55832425
Drug withdrawal syndrome 345.37 10.00 437 194630 25420 56071580
Overdose 336.29 10.00 965 194102 104865 55992135
Sopor 327.23 10.00 383 194684 20539 56076461
Arthropathy 301.44 10.00 159 194908 200116 55896884
Psychotic disorder 298.67 10.00 388 194679 23170 56073830
Infusion related reaction 298.44 10.00 177 194890 208754 55888246
Pericarditis 296.11 10.00 21 195046 108902 55988098
Joint swelling 283.26 10.00 353 194714 289447 55807553
Treatment failure 264.26 10.00 130 194937 170262 55926738
Cardiac arrest 262.55 10.00 775 194292 85539 56011461
Tremor 258.20 10.00 964 194103 120125 55976875
Wound 232.29 10.00 95 194972 138709 55958291
Swelling 230.10 10.00 296 194771 239475 55857525
Intentional self-injury 228.39 10.00 352 194715 24640 56072360
Irritability 227.12 10.00 385 194682 29203 56067797
Alopecia 226.43 10.00 420 194647 293038 55803962
Stubbornness 220.21 10.00 70 194997 255 56096745
Helicobacter infection 218.39 10.00 8 195059 73260 56023740
Rash 213.86 10.00 931 194136 492116 55604884
Rheumatoid factor positive 211.34 10.00 6 195061 69054 56027946
Abdominal discomfort 208.48 10.00 403 194664 276871 55820129
Agitation 202.71 10.00 536 194531 55500 56041500
Panic attack 202.49 10.00 299 194768 20148 56076852
Drug dependence 199.80 10.00 313 194754 22220 56074780
Hypersensitivity 199.50 10.00 365 194702 256043 55840957
Schizophrenia 191.10 10.00 208 194859 10291 56086709
Insomnia 176.59 10.00 1204 193863 190656 55906344
Poisoning 174.96 10.00 219 194848 12594 56084406
Withdrawal syndrome 161.67 10.00 255 194812 18207 56078793
Infection 161.06 10.00 279 194788 199927 55897073
Abnormal behaviour 158.52 10.00 266 194801 20006 56076994
Acute kidney injury 158.37 10.00 377 194690 240386 55856614
Hypomania 157.72 10.00 133 194934 4769 56092231
Therapeutic product effect decreased 155.53 10.00 216 194851 169236 55927764
Maternal exposure during pregnancy 155.37 10.00 261 194806 189292 55907708
Serotonin syndrome 153.14 10.00 305 194762 26185 56070815
Neuroleptic malignant syndrome 151.67 10.00 193 194874 11285 56085715
Dyskinesia 150.44 10.00 320 194747 28788 56068212
Discomfort 149.81 10.00 162 194905 141599 55955401
Folliculitis 145.42 10.00 12 195055 54967 56042033
Mental disorder 144.00 10.00 278 194789 23326 56073674
Muscle injury 142.99 10.00 10 195057 52490 56044510
Stomatitis 142.77 10.00 125 194942 120685 55976315
Thinking abnormal 142.31 10.00 174 194893 9767 56087233
General physical health deterioration 140.32 10.00 233 194834 169777 55927223
Unresponsive to stimuli 139.51 10.00 327 194740 31398 56065602
Anger 138.29 10.00 186 194881 11486 56085514
Disturbance in attention 137.25 10.00 330 194737 32210 56064790
Drug hypersensitivity 136.59 10.00 492 194575 274713 55822287
Intentional product misuse 135.67 10.00 440 194627 51064 56045936
Febrile neutropenia 134.95 10.00 101 194966 105444 55991556
Mania 134.09 10.00 182 194885 11338 56085662
Arthralgia 132.38 10.00 1108 193959 500561 55596439
Hepatic enzyme increased 132.27 10.00 245 194822 171139 55925861
Mood altered 130.37 10.00 194 194873 13161 56083839
Aggression 129.16 10.00 255 194812 21751 56075249
Restless legs syndrome 128.04 10.00 219 194848 16728 56080272
Tardive dyskinesia 125.52 10.00 147 194920 7884 56089116
Speech disorder 124.92 10.00 348 194719 37145 56059855
Sensitisation 124.28 10.00 86 194981 2282 56094718
Ataxia 123.44 10.00 197 194870 14206 56082794
Dystonia 120.63 10.00 180 194887 12241 56084759
Hyperhidrosis 119.30 10.00 642 194425 93446 56003554
Drug interaction 119.14 10.00 1180 193887 208575 55888425
Nightmare 118.74 10.00 211 194856 16615 56080385
Lower respiratory tract infection 118.17 10.00 134 194933 114660 55982340
Impaired healing 117.74 10.00 78 194989 86763 56010237
Crying 115.79 10.00 240 194827 21200 56075800
Polycystic ovaries 115.12 10.00 94 194973 3220 56093780
Anaemia 115.11 10.00 506 194561 267005 55829995
Feeling abnormal 110.90 10.00 818 194249 132784 55964216
Depressed level of consciousness 110.09 10.00 437 194630 55996 56041004
Ejection fraction 106.13 10.00 69 194998 1646 56095354
Epilepsy 104.39 10.00 254 194813 24977 56072023
Peripheral swelling 102.78 10.00 441 194626 234285 55862715
Memory impairment 101.96 10.00 579 194488 85978 56011022
Hallucination 101.90 10.00 388 194679 48761 56048239
Amnesia 101.29 10.00 372 194695 45950 56051050
Paranoia 100.50 10.00 153 194914 10591 56086409
Drooling 98.67 10.00 88 194979 3406 56093594
Neutropenia 95.91 10.00 258 194809 157909 55939091
Thrombocytopenia 93.77 10.00 208 194859 136016 55960984
Feeling of despair 91.96 10.00 69 194998 2084 56094916
Balance disorder 91.53 10.00 514 194553 76006 56020994
Nervousness 91.47 10.00 264 194803 28751 56068249
Off label use 90.51 10.00 1370 193697 554810 55542190
Mydriasis 90.21 10.00 148 194919 10923 56086077
Gastric pH decreased 89.22 10.00 45 195022 649 56096351
Sedation 87.52 10.00 293 194774 34561 56062439
Rheumatic fever 86.40 10.00 3 195064 28824 56068176
Muscle rigidity 86.07 10.00 142 194925 10529 56086471
Sleep disorder due to general medical condition, insomnia type 85.96 10.00 22 195045 43316 56053684
Atrial fibrillation 85.46 10.00 154 194913 108743 55988257
Dissociation 84.95 10.00 71 194996 2514 56094486
Dysarthria 84.28 10.00 315 194752 39235 56057765
Drug ineffective 83.94 10.00 2487 192580 916502 55180498
Drug withdrawal convulsions 82.34 10.00 54 195013 1308 56095692
Diarrhoea 81.11 10.00 1644 193423 636863 55460137
Mood swings 80.69 10.00 179 194888 16568 56080432
Irritable bowel syndrome 80.65 10.00 71 194996 68387 56028613
Cogwheel rigidity 79.82 10.00 60 195007 1817 56095183
Restlessness 77.24 10.00 235 194832 26351 56070649
Bipolar disorder 76.71 10.00 112 194955 7468 56089532
Multiple sclerosis relapse 75.28 10.00 332 194735 44571 56052429
Rhinitis allergic 74.12 10.00 117 194950 8357 56088643
Sepsis 74.01 10.00 243 194824 139597 55957403
Myoglobin urine present 73.64 10.00 37 195030 529 56096471
Disease progression 72.84 10.00 160 194907 105013 55991987
Gastrointestinal disorder 72.79 10.00 178 194889 112524 55984476
Akathisia 72.31 10.00 117 194950 8535 56088465
Product use issue 72.25 10.00 365 194702 185676 55911324
Product substitution issue 71.42 10.00 157 194910 14442 56082558
Derealisation 70.62 10.00 45 195022 1036 56095964
Bradyphrenia 70.18 10.00 100 194967 6520 56090480
Vision blurred 70.02 10.00 510 194557 82433 56014567
Status epilepticus 69.78 10.00 159 194908 14982 56082018
Hypersomnia 68.12 10.00 165 194902 16176 56080824
Nasopharyngitis 68.01 10.00 467 194600 220492 55876508
Loss of consciousness 67.34 10.00 626 194441 108723 55988277
Malignant neoplasm progression 66.26 10.00 95 194972 73492 56023508
Hallucination, auditory 65.77 10.00 132 194935 11392 56085608
Hip arthroplasty 63.65 10.00 27 195040 38596 56058404
Emotional disorder 63.32 10.00 135 194932 12160 56084840
Head injury 61.41 10.00 209 194858 24857 56072143
Pleural effusion 60.89 10.00 128 194939 85352 56011648
Respiratory depression 60.01 10.00 133 194934 12302 56084698
Blister 59.85 10.00 186 194881 108701 55988299
Disorientation 59.33 10.00 268 194799 36345 56060655
Multiple-drug resistance 59.23 10.00 71 194996 3903 56093097
Plasma cell myeloma 59.13 10.00 45 195022 46601 56050399
Coma 58.75 10.00 381 194686 59274 56037726
Delusion 58.75 10.00 124 194943 11091 56085909
Psoriatic arthropathy 58.65 10.00 104 194963 73904 56023096
Interstitial lung disease 58.27 10.00 67 195000 56996 56040004
Drug screen negative 58.07 10.00 25 195042 245 56096755
Mental status changes 57.44 10.00 270 194797 37231 56059769
Knee arthroplasty 57.00 10.00 42 195025 44217 56052783
Pancytopenia 56.59 10.00 141 194926 88574 56008426
Lactic acidosis 56.21 10.00 26 195041 35320 56061680
Migraine 56.02 10.00 502 194565 86295 56010705
Lethargy 55.94 10.00 337 194730 51104 56045896
Sleep apnoea syndrome 55.88 10.00 208 194859 25853 56071147
H1N1 influenza 55.71 10.00 46 195021 1601 56095399
Gait disturbance 55.11 10.00 833 194234 162488 55934512
Renal impairment 54.89 10.00 124 194943 80589 56016411
Multiple sclerosis 54.77 10.00 216 194851 27586 56069414
Mucosal inflammation 54.65 10.00 41 195026 42769 56054231
Depersonalisation/derealisation disorder 54.65 10.00 41 195026 1238 56095762
Ill-defined disorder 54.60 10.00 96 194971 68447 56028553
Jaundice cholestatic 53.62 10.00 80 194987 5439 56091561
Cardiac failure 53.52 10.00 129 194938 81964 56015036
Exposure via ingestion 53.50 10.00 57 195010 2751 56094249
Muscle spasms 52.45 10.00 716 194351 136655 55960345
Myocardial stunning 52.39 10.00 20 195047 139 56096861
Incontinence 52.01 10.00 115 194952 10620 56086380
Gastrointestinal haemorrhage 51.39 10.00 117 194950 75834 56021166
Therapeutic response unexpected 50.77 10.00 152 194915 16892 56080108
Hypoaesthesia oral 50.43 10.00 118 194949 11313 56085687
Sluggishness 50.20 10.00 71 194996 4597 56092403
Granulocytopenia 49.84 10.00 76 194991 5268 56091732
C-reactive protein increased 48.68 10.00 127 194940 78557 56018443
Abnormal dreams 48.60 10.00 105 194962 9544 56087456
Electrocardiogram QT prolonged 48.58 10.00 340 194727 54248 56042752
Myelosuppression 48.48 10.00 3 195064 17452 56079548
On and off phenomenon 48.05 10.00 42 195025 1582 56095418
Depressed mood 48.03 10.00 251 194816 36108 56060892
Stress 47.86 10.00 359 194708 58551 56038449
Nephrectomy 47.68 10.00 37 195030 1176 56095824
Hyperprolactinaemia 47.48 10.00 61 195006 3600 56093400
Major depression 47.08 10.00 90 194977 7494 56089506
Feeling of body temperature change 46.72 10.00 68 194999 4521 56092479
Toxic encephalopathy 46.52 10.00 78 194989 5860 56091140
Bone marrow failure 46.25 10.00 20 195047 28266 56068734
Fall 46.20 10.00 1591 193476 355919 55741081
Dizziness 45.42 10.00 1661 193406 374479 55722521
Movement disorder 45.22 10.00 158 194909 19040 56077960
Mobility decreased 45.11 10.00 183 194884 98808 55998192
Hypokinesia 44.78 10.00 121 194946 12682 56084318
Pain 44.77 10.00 1862 193205 661322 55435678
Substance abuse 44.55 10.00 66 195001 4459 56092541
Bradykinesia 43.82 10.00 68 194999 4786 56092214
Urinary tract discomfort 43.39 10.00 22 195045 321 56096679
Carpal tunnel syndrome 43.32 10.00 150 194917 17994 56079006
Panic disorder 42.99 10.00 48 195019 2443 56094557
Decorticate posture 42.96 10.00 21 195046 282 56096718
Broncholithiasis 42.62 10.00 19 195048 204 56096796
Parkinsonism 42.62 10.00 99 194968 9447 56087553
Dysphoria 42.55 10.00 67 195000 4775 56092225
Personality disorder 41.94 10.00 69 194998 5104 56091896
Dyspnoea 41.84 10.00 1655 193412 590922 55506078
Myocardial depression 41.31 10.00 24 195043 465 56096535
Generalised tonic-clonic seizure 41.15 10.00 197 194870 27369 56069631
Blood test abnormal 40.94 10.00 117 194950 12667 56084333
Middle insomnia 40.85 10.00 106 194961 10844 56086156
Pleurothotonus 40.78 10.00 35 195032 1286 56095714
Herpes zoster 40.73 10.00 131 194936 75758 56021242
Platelet count decreased 40.54 10.00 210 194857 106173 55990827
Galactorrhoea 40.06 10.00 58 195009 3837 56093163
Hypercalcaemia 39.93 10.00 19 195048 25392 56071608
Heart rate increased 39.48 10.00 452 194615 82821 56014179
Melaena 38.89 10.00 25 195042 28265 56068735
Menstrual disorder 38.77 10.00 63 195004 4612 56092388
Neutrophil count decreased 38.59 10.00 71 194996 49751 56047249
Breast hyperplasia 38.49 10.00 19 195048 261 56096739
Atonic seizures 38.21 10.00 25 195042 603 56096397
Blood creatinine increased 37.96 10.00 146 194921 80045 56016955
Impaired driving ability 37.84 10.00 58 195009 4038 56092962
Muscle twitching 37.67 10.00 133 194934 16109 56080891
Skin ulcer 37.64 10.00 47 195020 38561 56058439
Palmar-plantar erythrodysaesthesia syndrome 37.57 10.00 13 195054 21052 56075948
Weight increased 37.52 10.00 1052 194015 228651 55868349
Rubber sensitivity 37.38 10.00 40 195027 1940 56095060
Pulmonary fibrosis 37.34 10.00 29 195038 29729 56067271
Lymph node calcification 37.31 10.00 19 195048 280 56096720
Nystagmus 37.24 10.00 70 194997 5755 56091245
Parosmia 37.07 10.00 62 195005 4649 56092351
Miosis 37.01 10.00 75 194992 6517 56090483
Dopamine dysregulation syndrome 36.88 10.00 16 195051 160 56096840
Aphasia 36.81 10.00 205 194862 30210 56066790
Psychomotor hyperactivity 36.57 10.00 95 194972 9725 56087275
Inflammation 36.53 10.00 120 194947 68951 56028049
Musculoskeletal stiffness 36.39 10.00 355 194712 155652 55941348
Hostility 36.37 10.00 38 195029 1793 56095207
Drug screen positive 36.24 10.00 52 195015 3412 56093588
Hallucinations, mixed 35.85 10.00 59 195008 4365 56092635
Urinary retention 35.84 10.00 192 194875 27882 56069118
Fear 35.38 10.00 123 194944 14785 56082215
Therapeutic product ineffective 35.28 10.00 33 195034 1359 56095641
Alveolar osteitis 35.25 10.00 23 195044 552 56096448
Pneumocystis jirovecii pneumonia 35.19 10.00 6 195061 15695 56081305
Product complaint 35.14 10.00 105 194962 11655 56085345
Libido increased 34.99 10.00 32 195035 1280 56095720
Blood creatine phosphokinase increased 34.90 10.00 190 194877 27762 56069238
Drug use disorder 34.82 10.00 60 195007 4609 56092391
Liver injury 34.81 10.00 57 195010 41791 56055209
Hyperkalaemia 34.70 10.00 78 194989 50787 56046213
Incoherent 34.68 10.00 57 195010 4212 56092788
Osteonecrosis of jaw 34.24 10.00 39 195028 33319 56063681
Intentional product use issue 34.11 10.00 204 194863 99529 55997471
Cardiac failure congestive 34.07 10.00 172 194895 87548 56009452
Electroencephalogram abnormal 33.95 10.00 51 195016 3488 56093512
Burning sensation 33.68 10.00 286 194781 48410 56048590
Tunnel vision 33.65 10.00 26 195041 821 56096179
Emotional distress 33.65 10.00 197 194870 29566 56067434
Persecutory delusion 33.61 10.00 43 195024 2527 56094473
Pneumonia aspiration 33.14 10.00 209 194858 32202 56064798
Pulmonary arterial hypertension 33.04 10.00 26 195041 26477 56070523
Oromandibular dystonia 32.71 10.00 20 195047 427 56096573
Muscle disorder 32.65 10.00 58 195009 4565 56092435
Adjustment disorder with mixed anxiety and depressed mood 32.65 10.00 12 195055 74 56096926
Sleep-related eating disorder 32.64 10.00 25 195042 779 56096221
Influenza like illness 32.57 10.00 339 194728 60649 56036351
Bruxism 32.35 10.00 47 195020 3119 56093881
Catatonia 32.30 10.00 53 195014 3911 56093089
Tension 32.23 10.00 45 195022 2879 56094121
Coma blister 32.19 10.00 14 195053 141 56096859
Feeling jittery 31.78 10.00 103 194964 11943 56085057
Stoma site discharge 31.31 10.00 31 195036 1371 56095629
Septic shock 31.28 10.00 107 194960 60728 56036272
Bone erosion 30.87 10.00 7 195060 14967 56082033
Musculoskeletal pain 30.46 10.00 161 194906 80991 56016009
Autonomic nervous system imbalance 30.23 10.00 41 195026 2552 56094448
Sleep disorder due to a general medical condition 29.90 10.00 84 194983 9006 56087994
Tinnitus 29.65 10.00 192 194875 29850 56067150
Bladder pain 29.08 10.00 34 195033 1820 56095180
Myoclonus 29.05 10.00 117 194950 15086 56081914
Adverse drug reaction 28.68 10.00 122 194945 65010 56031990
Developmental glaucoma 28.46 10.00 10 195057 53 56096947
Macular degeneration 28.41 10.00 15 195052 18893 56078107
Drug tolerance decreased 28.19 10.00 6 195061 13405 56083595
Obsessive-compulsive disorder 28.13 10.00 48 195019 3658 56093342
Oropharyngeal oedema 28.05 10.00 16 195051 299 56096701
Extrapyramidal disorder 27.65 10.00 100 194967 12256 56084744
Red blood cell sedimentation rate increased 27.64 10.00 53 195014 36570 56060430
Anticonvulsant drug level above therapeutic 27.43 10.00 19 195048 505 56096495
Angioedema 27.12 10.00 65 195002 41388 56055612
Hypocalcaemia 27.01 10.00 36 195031 28724 56068276
Formication 27.00 10.00 49 195018 3921 56093079
Rash pruritic 26.70 10.00 93 194974 52501 56044499
Apathy 26.65 10.00 74 194993 7880 56089120
Cytomegalovirus infection 26.59 10.00 17 195050 19279 56077721
Leukopenia 26.48 10.00 141 194926 70799 56026201
Animal scratch 26.46 10.00 25 195042 1043 56095957
Sinusitis 26.35 10.00 504 194563 197077 55899923
Urinary bladder rupture 26.35 10.00 12 195055 136 56096864
Head titubation 26.32 10.00 22 195045 779 56096221
Forced expiratory volume decreased 26.14 10.00 53 195014 4607 56092393
Right ventricular failure 26.12 10.00 12 195055 16367 56080633
Neutropenic sepsis 26.02 10.00 10 195057 15175 56081825
Creatinine renal clearance decreased 25.94 10.00 9 195058 14550 56082450
Post-traumatic neck syndrome 25.72 10.00 33 195034 1945 56095055
Panic reaction 25.71 10.00 47 195020 3783 56093217
Pruritus 25.47 10.00 870 194197 315753 55781247
Paralysis 25.45 10.00 79 194988 8953 56088047
Mutism 25.40 10.00 28 195039 1405 56095595
Blood sodium decreased 25.36 10.00 148 194919 22186 56074814
Neoplasm progression 25.35 10.00 45 195022 31971 56065029
Dysphagia 25.34 10.00 412 194655 81535 56015465
Affect lability 25.31 10.00 85 194982 10040 56086960
Aspiration 25.14 10.00 82 194985 9539 56087461
Ketosis-prone diabetes mellitus 25.04 10.00 7 195060 14 56096986
Road traffic accident 24.87 10.00 174 194893 27753 56069247
Bipolar I disorder 24.87 10.00 30 195037 1660 56095340
Device expulsion 24.84 10.00 42 195025 30407 56066593
Coordination abnormal 24.81 10.00 98 194969 12523 56084477
Intervertebral disc protrusion 24.79 10.00 144 194923 21550 56075450
Suspected suicide 24.74 10.00 57 195010 5409 56091591
Tachyphrenia 24.35 10.00 26 195041 1258 56095742
Renal failure 24.29 10.00 255 194812 110245 55986755
Exposure during pregnancy 24.09 10.00 330 194737 136012 55960988
Conversion disorder 23.98 10.00 29 195038 1609 56095391
Ejection fraction abnormal 23.97 10.00 24 195043 1076 56095924
Anorgasmia 23.89 10.00 18 195049 547 56096453
Altered state of consciousness 23.87 10.00 149 194918 22872 56074128
Amylase increased 23.76 10.00 58 195009 5713 56091287
Freezing phenomenon 23.66 10.00 24 195043 1093 56095907
Haemoglobin decreased 23.58 10.00 325 194742 133812 55963188
Upper gastrointestinal haemorrhage 23.54 10.00 15 195052 17039 56079961
Libido decreased 23.53 10.00 35 195032 2373 56094627
Psychomotor retardation 23.34 10.00 44 195023 3625 56093375
Antipsychotic drug level increased 23.32 10.00 41 195026 3201 56093799
Hereditary angioedema 23.31 10.00 64 195003 6771 56090229
Sensory loss 23.21 10.00 76 194991 8859 56088141
Neuropathy peripheral 23.20 10.00 236 194831 102657 55994343
Weight abnormal 23.06 10.00 24 195043 1127 56095873
Abulia 22.88 10.00 16 195051 432 56096568
Liver function test increased 22.77 10.00 39 195028 28094 56068906
Urinary incontinence 22.74 10.00 178 194889 29407 56067593
Hyperbilirubinaemia 22.74 10.00 4 195063 10231 56086769
Logorrhoea 22.71 10.00 34 195033 2318 56094682
Euphoric mood 22.61 10.00 48 195019 4310 56092690
Impulsive behaviour 22.58 10.00 27 195040 1480 56095520
Urticaria 22.50 10.00 359 194708 144317 55952683
Live birth 22.29 10.00 21 195046 19584 56077416
Tongue discolouration 22.22 10.00 38 195029 2901 56094099
Proteinuria 22.20 10.00 17 195050 17553 56079447
Pyrexia 22.14 10.00 1206 193861 417567 55679433
Acute myeloid leukaemia 21.99 10.00 16 195051 16956 56080044
Hyperreflexia 21.87 10.00 53 195014 5197 56091803
Cholelithiasis 21.85 10.00 221 194846 39243 56057757
Peroneal nerve palsy 21.85 10.00 48 195019 4413 56092587
Suicidal behaviour 21.84 10.00 34 195033 2399 56094601
Transplant rejection 21.82 10.00 4 195063 9930 56087070
Drug abuser 21.66 10.00 37 195030 2822 56094178
Lupus-like syndrome 21.60 10.00 8 195059 12419 56084581
Hypothermia 21.50 10.00 93 194974 12377 56084623
Soft tissue injury 21.30 10.00 27 195040 1572 56095428
Concussion 21.30 10.00 70 194997 8176 56088824
Therapy non-responder 21.24 10.00 125 194942 61230 56035770
Hypoventilation 21.22 10.00 47 195020 4345 56092655
Cognitive disorder 21.21 10.00 262 194805 48871 56048129
Seizure cluster 21.15 10.00 12 195055 222 56096778
Band neutrophil percentage increased 21.15 10.00 12 195055 222 56096778
Orthostatic tremor 21.14 10.00 6 195061 13 56096987
Hyponatraemia 21.13 10.00 239 194828 101900 55995100
Salivary hypersecretion 21.12 10.00 63 195004 6987 56090013
Alcohol abuse 21.08 10.00 30 195037 1954 56095046
Dependence 20.92 10.00 30 195037 1967 56095033
Stoma site hypergranulation 20.88 10.00 13 195054 287 56096713
Paranasal sinus discomfort 20.80 10.00 40 195027 3345 56093655
Psychotic disorder due to a general medical condition 20.72 10.00 12 195055 231 56096769
Diverticulitis 20.58 10.00 60 195007 35792 56061208
Limb injury 20.57 10.00 140 194927 22130 56074870
Anaphylactic reaction 20.52 10.00 120 194947 58875 56038125
Heart rate abnormal 20.43 10.00 47 195020 4456 56092544
Choking 20.29 10.00 73 194994 8924 56088076
Hyperammonaemic encephalopathy 20.27 10.00 31 195036 2154 56094846
Weight gain poor 20.26 10.00 19 195048 785 56096215
Post-traumatic stress disorder 20.19 10.00 47 195020 4491 56092509
Hypertension 20.15 10.00 669 194398 243609 55853391
Secretion discharge 20.02 10.00 81 194986 10465 56086535
Ascites 20.01 10.00 65 195002 37479 56059521
Decreased interest 19.97 10.00 37 195030 3009 56093991
Screaming 19.90 10.00 37 195030 3017 56093983
Dysgraphia 19.88 10.00 35 195032 2735 56094265
Colitis 19.86 10.00 76 194991 41735 56055265
Sebaceous gland infection 19.72 10.00 10 195057 146 56096854
Attention deficit hyperactivity disorder 19.65 10.00 34 195033 2620 56094380
Hyperammonaemia 19.65 10.00 49 195018 4891 56092109
Anaphylactic shock 19.63 10.00 28 195039 21712 56075288
Sexual abuse 19.55 10.00 11 195056 200 56096800
Intellectual disability 19.48 10.00 19 195048 825 56096175
Social anxiety disorder 19.45 10.00 14 195053 396 56096604
Tic 19.42 10.00 23 195044 1248 56095752
Antidepressant drug level above therapeutic 19.36 10.00 14 195053 399 56096601
Dysstasia 19.29 10.00 124 194943 19230 56077770
Food craving 19.22 10.00 25 195042 1494 56095506
Blood parathyroid hormone decreased 19.18 10.00 3 195064 8361 56088639
Stereotypy 19.09 10.00 14 195053 408 56096592
Cardiac disorder 19.08 10.00 243 194824 45644 56051356
Stoma site pain 18.88 10.00 19 195048 857 56096143
Diplopia 18.78 10.00 128 194939 20241 56076759
Somnambulism 18.69 10.00 49 195018 5043 56091957
Anticonvulsant drug level below therapeutic 18.64 10.00 16 195051 588 56096412
Erythema 18.63 10.00 405 194662 155534 55941466
Troponin increased 18.58 10.00 69 194998 8566 56088434
Cerebellar atrophy 18.57 10.00 17 195050 681 56096319
Blood triglycerides increased 18.56 10.00 85 194982 11592 56085408
Hypervolaemia 18.51 10.00 40 195027 26418 56070582
Hyperthermia 18.49 10.00 67 195000 8218 56088782
Confusional state 18.42 10.00 890 194177 207265 55889735
Decompression sickness 18.42 10.00 7 195060 48 56096952
Sleep disorder 18.32 10.00 333 194734 67330 56029670
Enthesopathy 18.25 10.00 3 195064 8060 56088940
Coma scale abnormal 18.06 10.00 47 195020 4816 56092184
Delirium 18.04 10.00 226 194841 42291 56054709
Weight decreased 18.02 10.00 1013 194054 239701 55857299
Pulmonary hypertension 17.95 10.00 64 195003 35880 56061120
Myoclonic epilepsy 17.84 10.00 21 195046 1132 56095868
Blood prolactin increased 17.81 10.00 37 195030 3272 56093728
Fibromyalgia 17.81 10.00 298 194769 59305 56037695
Areflexia 17.70 10.00 34 195033 2841 56094159
Hypokalaemia 17.61 10.00 226 194841 94211 56002789
Mitral valve thickening 17.57 10.00 5 195062 11 56096989
White blood cell count decreased 17.52 10.00 319 194748 125671 55971329
Osteoporosis 17.51 10.00 107 194960 51945 56045055
Hypothyroidism 17.50 10.00 206 194861 37990 56059010
Inappropriate schedule of product administration 17.47 10.00 395 194672 82992 56014008
Cytopenia 17.43 10.00 6 195061 9749 56087251
Bronchial wall thickening 17.26 10.00 20 195047 1060 56095940
Psychiatric symptom 17.16 10.00 46 195021 4798 56092202
Shock haemorrhagic 17.13 10.00 5 195062 9028 56087972
Trismus 17.10 10.00 38 195029 3520 56093480
Disorganised speech 17.04 10.00 20 195047 1075 56095925
Basal cell carcinoma 16.93 10.00 39 195028 25182 56071818
Initial insomnia 16.85 10.00 50 195017 5529 56091471
Change in seizure presentation 16.82 10.00 11 195056 265 56096735
Haematochezia 16.81 10.00 86 194981 43632 56053368
Arthritis 16.81 10.00 244 194823 99608 55997392
Myelocyte percentage increased 16.76 10.00 10 195057 204 56096796
Epistaxis 16.69 10.00 150 194917 66873 56030127
Hypomagnesaemia 16.54 10.00 39 195028 24976 56072024
Thrombotic microangiopathy 16.46 10.00 6 195061 9405 56087595
Hypnopompic hallucination 16.19 10.00 6 195061 38 56096962
Impulse-control disorder 16.17 10.00 16 195051 707 56096293
Jaundice 16.16 10.00 45 195022 27249 56069751
Compulsive shopping 16.10 10.00 16 195051 711 56096289
Adverse event 16.05 10.00 119 194948 55257 56041743
Blood growth hormone increased 16.03 10.00 13 195054 441 56096559
Self-injurious ideation 15.98 10.00 29 195038 2321 56094679
Fatigue 15.90 10.00 2445 192622 786107 55310893
Pneumonitis 15.90 10.00 56 195011 31508 56065492
Headache 15.86 10.00 2189 192878 556855 55540145
Anticonvulsant drug level increased 15.86 10.00 22 195045 1399 56095601
Injection site pruritus 15.83 10.00 83 194984 41848 56055152
Asthma 15.82 10.00 507 194560 112263 55984737
Cytokine release syndrome 15.80 10.00 9 195058 10866 56086134
Lung disorder 15.74 10.00 112 194955 52485 56044515
Increased appetite 15.72 10.00 66 195001 8669 56088331
Visual impairment 15.70 10.00 352 194715 73850 56023150
Neuropsychiatric symptoms 15.67 10.00 15 195052 636 56096364
Tearfulness 15.65 10.00 38 195029 3730 56093270
Metastases to liver 15.64 10.00 32 195035 21554 56075446
Anhedonia 15.63 10.00 72 194995 9842 56087158
Sinus pain 15.59 10.00 31 195036 2657 56094343
Alcohol poisoning 15.59 10.00 25 195042 1810 56095190
Bronchopulmonary aspergillosis allergic 15.56 10.00 22 195045 1424 56095576
Mental impairment 15.56 10.00 86 194981 12636 56084364
Haemoglobin urine 15.47 10.00 8 195059 122 56096878
Narcotic bowel syndrome 15.41 10.00 8 195059 123 56096877
Hyperphagia 15.31 10.00 23 195044 1573 56095427
Femur fracture 15.28 10.00 77 194990 39218 56057782
Hyperkeratosis 15.28 10.00 47 195020 5300 56091700
Peripheral pulse decreased 15.21 10.00 6 195061 46 56096954
Peripheral venous disease 15.14 10.00 8 195059 10071 56086929
Flat affect 15.07 10.00 21 195046 1341 56095659
Condition aggravated 15.07 10.00 1011 194056 343887 55753113
Feelings of worthlessness 15.05 10.00 11 195056 319 56096681
Sensitivity to weather change 15.04 10.00 54 195013 6595 56090405
Fibrous histiocytoma 14.98 10.00 13 195054 485 56096515
Full blood count decreased 14.97 10.00 37 195030 23312 56073688
Cyanosis 14.97 10.00 100 194967 15710 56081290
Nasal oedema 14.82 10.00 19 195048 1119 56095881
Monocyte count abnormal 14.73 10.00 9 195058 192 56096808
Cerebral atrophy 14.70 10.00 43 195024 4717 56092283
Stoma site erythema 14.67 10.00 18 195049 1014 56095986
Paraesthesia 14.65 10.00 572 194495 129942 55967058
Congenital jaw malformation 14.64 10.00 5 195062 24 56096976
Focal dyscognitive seizures 14.52 10.00 31 195036 2794 56094206
Generalised anxiety disorder 14.52 10.00 25 195042 1919 56095081
Sputum discoloured 14.51 10.00 92 194975 14200 56082800
Sternal fracture 14.48 10.00 26 195041 2064 56094936
Right ventricular systolic pressure decreased 14.47 10.00 5 195062 25 56096975
Rib fracture 14.42 10.00 120 194947 20189 56076811
Electrocardiogram QRS complex shortened 14.33 10.00 12 195055 426 56096574
Pupil fixed 14.32 10.00 23 195044 1667 56095333
Cast application 14.31 10.00 5 195062 26 56096974
Poor quality sleep 14.30 10.00 108 194959 17647 56079353
Suspected product quality issue 14.29 10.00 9 195058 203 56096797
Disseminated intravascular coagulation 14.28 10.00 25 195042 17860 56079140
Parasomnia 14.28 10.00 12 195055 428 56096572
Liver function test abnormal 14.28 10.00 96 194971 45575 56051425
Upper respiratory tract infection 14.28 10.00 168 194899 71120 56025880
Myocardial infarction 14.25 10.00 231 194836 92639 56004361
Pre-existing condition improved 14.19 10.00 57 195010 7341 56089659
Piloerection 14.17 10.00 11 195056 350 56096650
Homicidal ideation 14.14 10.00 23 195044 1685 56095315
Accidental overdose 14.05 10.00 120 194947 20341 56076659
Product quality issue 14.03 10.00 170 194897 31566 56065434
Onychophagia 14.01 10.00 6 195061 58 56096942
Parkinsonian gait 13.98 10.00 12 195055 441 56096559
Feeling cold 13.89 10.00 123 194944 21064 56075936
Pollakiuria 13.89 10.00 141 194926 25061 56071939
Periodic limb movement disorder 13.87 10.00 9 195058 214 56096786
Encephalopathy 13.82 10.00 185 194882 35140 56061860
Enuresis 13.73 10.00 27 195040 2296 56094704
Clumsiness 13.65 10.00 24 195043 1873 56095127
Blood urine present 13.60 10.00 87 194980 13468 56083532
Fear of injection 13.52 10.00 3 195064 6512 56090488
Drop attacks 13.46 10.00 14 195053 657 56096343
Feeling drunk 13.42 10.00 36 195031 3756 56093244
Torticollis 13.41 10.00 23 195044 1760 56095240
Brain death 13.38 10.00 31 195036 2952 56094048
Cholestasis 13.38 10.00 48 195019 26865 56070135
Cardiac infection 13.32 10.00 11 195056 383 56096617
Circulatory collapse 13.31 10.00 33 195034 20770 56076230
Flight of ideas 13.29 10.00 11 195056 384 56096616
Nephrogenic diabetes insipidus 13.28 10.00 16 195051 884 56096116
Oculogyric crisis 13.27 10.00 21 195046 1503 56095497
Vertigo 13.20 10.00 264 194803 54308 56042692
Tonic clonic movements 13.19 10.00 19 195048 1251 56095749
Colitis ulcerative 13.15 10.00 42 195025 24349 56072651
Temperature intolerance 13.13 10.00 59 195008 7981 56089019
Decreased activity 13.13 10.00 46 195021 5550 56091450
Drug level above therapeutic 13.08 10.00 39 195028 4323 56092677
Abscess 13.05 10.00 20 195047 15061 56081939
Sudden unexplained death in epilepsy 13.02 10.00 10 195057 313 56096687
Aerophagia 12.93 10.00 4 195063 13 56096987
Accidental exposure to product by child 12.85 10.00 18 195049 1155 56095845
Hallucination, visual 12.82 10.00 104 194963 17364 56079636
Drug screen false positive 12.80 10.00 15 195052 805 56096195
Barotrauma 12.76 10.00 8 195059 179 56096821
Breast cancer stage I 12.67 10.00 3 195064 6227 56090773
Dysphemia 12.65 10.00 27 195040 2433 56094567
Respiratory rate decreased 12.60 10.00 32 195035 3230 56093770
Distractibility 12.52 10.00 11 195056 417 56096583
Pericardial effusion 12.52 10.00 50 195017 27125 56069875
Ear congestion 12.51 10.00 25 195042 2150 56094850
Family stress 12.48 10.00 13 195054 611 56096389
Drug ineffective for unapproved indication 12.41 10.00 140 194927 25553 56071447
Partial seizures 12.38 10.00 44 195023 5346 56091654
Klebsiella test positive 12.35 10.00 16 195051 952 56096048
Sensory disturbance 12.27 10.00 80 194987 12463 56084537
Bradycardia neonatal 12.26 10.00 15 195052 842 56096158
Gaze palsy 12.26 10.00 19 195048 1336 56095664
Eye pain 12.26 10.00 162 194905 30685 56066315
Fractured coccyx 12.25 10.00 16 195051 960 56096040
Affective disorder 12.24 10.00 45 195022 5558 56091442
Asphyxia 12.24 10.00 46 195021 5743 56091257
Suspiciousness 12.23 10.00 10 195057 343 56096657
Fluid retention 12.20 10.00 124 194943 53954 56043046
Nail disorder 12.18 10.00 13 195054 11438 56085562
Acute myocardial infarction 12.14 10.00 59 195008 30334 56066666
Haemangioma congenital 12.13 10.00 11 195056 435 56096565
Infantile spasms 12.13 10.00 9 195058 267 56096733
Stupor 12.12 10.00 36 195031 3982 56093018
Aplastic anaemia 12.12 10.00 8 195059 8920 56088080
Hyperacusis 12.12 10.00 23 195044 1905 56095095
Haematotoxicity 12.09 10.00 7 195060 8376 56088624
Sensorimotor disorder 12.05 10.00 11 195056 439 56096561
Illusion 12.02 10.00 16 195051 978 56096022
Breast cancer metastatic 12.01 10.00 22 195045 15447 56081553
Pathogen resistance 11.99 10.00 3 195064 5997 56091003
Oculocephalogyric reflex absent 11.94 10.00 3 195064 3 56096997
Large intestine operation 11.94 10.00 3 195064 3 56096997
Acute generalised exanthematous pustulosis 11.90 10.00 10 195057 9859 56087141
Blood pressure decreased 11.83 10.00 278 194789 58772 56038228
Band neutrophil count increased 11.80 10.00 10 195057 361 56096639
Bronchopulmonary aspergillosis 11.78 10.00 7 195060 8257 56088743
Fever neonatal 11.74 10.00 4 195063 19 56096981
Temporomandibular joint syndrome 11.73 10.00 34 195033 3710 56093290
Hypertonia 11.72 10.00 36 195031 4056 56092944
Apnoea 11.72 10.00 53 195014 7189 56089811
Neoplasm malignant 11.71 10.00 51 195016 27004 56069996
Metastases to lung 11.70 10.00 14 195053 11704 56085296
Hypoaesthesia 11.68 10.00 601 194466 140890 55956110
Essential tremor 11.66 10.00 16 195051 1007 56095993
Dysuria 11.64 10.00 160 194907 30569 56066431
Deformity 11.64 10.00 11 195056 10244 56086756
Conjunctivitis allergic 11.61 10.00 14 195053 774 56096226
Lip and/or oral cavity cancer 11.61 10.00 13 195054 664 56096336
Eating disorder 11.58 10.00 100 194967 17005 56079995
Nasal polyps 11.56 10.00 31 195036 3234 56093766
Cholecystitis chronic 11.33 10.00 65 195002 9683 56087317
Soft tissue haemorrhage 11.25 10.00 8 195059 222 56096778
Electrocardiogram QRS complex prolonged 11.19 10.00 43 195024 5424 56091576
Toxicologic test abnormal 11.19 10.00 13 195054 691 56096309
Obstructive airways disorder 11.16 10.00 100 194967 17182 56079818
Respiratory disorder neonatal 11.12 10.00 15 195052 929 56096071
COVID-19 11.08 10.00 188 194879 74870 56022130
Body height increased 11.03 10.00 5 195062 56 56096944
Chronic papillomatous dermatitis 11.03 10.00 5 195062 56 56096944
Bone density decreased 10.97 10.00 17 195050 12743 56084257
Behaviour disorder 10.89 10.00 27 195040 2686 56094314
Cushingoid 10.89 10.00 6 195061 7378 56089622
Drug detoxification 10.88 10.00 7 195060 164 56096836
Oliguria 10.88 10.00 8 195059 8432 56088568
Joint range of motion decreased 10.86 10.00 48 195019 25317 56071683
Pulmonary toxicity 10.79 10.00 7 195060 7876 56089124
Blepharospasm 10.78 10.00 31 195036 3367 56093633
Incision site erythema 10.77 10.00 10 195057 408 56096592
Binge eating 10.71 10.00 10 195057 411 56096589
Transfusion 10.70 10.00 19 195048 13501 56083499
Antisocial behaviour 10.69 10.00 9 195058 322 56096678
Nasal disorder 10.68 10.00 26 195041 2556 56094444
Automatism 10.65 10.00 5 195062 61 56096939
Facet joint syndrome 10.59 10.00 5 195062 6712 56090288
Pancreatolithiasis 10.57 10.00 8 195059 245 56096755
Myelodysplastic syndrome 10.51 10.00 26 195041 16380 56080620
Rash maculo-papular 10.48 10.00 58 195009 28849 56068151
Urine oxalate increased 10.48 10.00 8 195059 248 56096752
Treatment noncompliance 10.45 10.00 165 194902 32458 56064542
Sleep terror 10.44 10.00 13 195054 743 56096257
Incision site haemorrhage 10.41 10.00 11 195056 526 56096474
Device use error 10.38 10.00 3 195064 5453 56091547
International normalised ratio increased 10.35 10.00 100 194967 43941 56053059
Retinal detachment 10.34 10.00 3 195064 5438 56091562
Multiple organ dysfunction syndrome 10.32 10.00 125 194942 52645 56044355
Large intestine polyp 10.31 10.00 53 195014 7574 56089426
Motor dysfunction 10.30 10.00 62 195005 9395 56087605
Blood iron decreased 10.28 10.00 77 194990 12550 56084450
Abdominal pain 10.25 10.00 765 194302 258040 55838960
Gastrointestinal procedural complication 10.24 10.00 7 195060 182 56096818
Clostridium difficile infection 10.18 10.00 54 195013 27144 56069856
Foetal growth restriction 10.14 10.00 6 195061 7093 56089907
Peritonitis 10.13 10.00 26 195041 16176 56080824
Soliloquy 10.11 10.00 7 195060 186 56096814
Incorrect dose administered 10.11 10.00 246 194821 52301 56044699
Breast cancer female 10.08 10.00 17 195050 12321 56084679
Social avoidant behaviour 10.02 10.00 27 195040 2825 56094175

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 1354.13 11.05 1557 103462 86201 31506124
Depression 903.66 11.05 1297 103722 89518 31502807
Completed suicide 815.32 11.05 1241 103778 90273 31502052
Toxicity to various agents 599.88 11.05 1628 103391 179859 31412466
Somnolence 409.92 11.05 971 104048 98474 31493851
Drug interaction 371.04 11.05 1518 103501 207025 31385300
Anxiety 328.55 11.05 845 104174 90188 31502137
Overdose 324.43 11.05 804 104215 83860 31508465
Sopor 305.84 11.05 275 104744 11277 31581048
Seizure 278.03 11.05 843 104176 98925 31493400
Coma 269.94 11.05 487 104532 40663 31551662
Intentional overdose 261.58 11.05 482 104537 40907 31551418
Neuroleptic malignant syndrome 253.59 11.05 296 104723 16573 31575752
Aggression 249.27 11.05 445 104574 36846 31555479
Suicide attempt 243.25 11.05 440 104579 36808 31555517
Agitation 241.59 11.05 546 104473 53623 31538702
Poisoning 239.53 11.05 229 104790 10162 31582163
Respiratory arrest 237.22 11.05 359 104660 25898 31566427
Suicidal ideation 230.07 11.05 424 104595 35982 31556343
Miosis 213.12 11.05 197 104822 8373 31583952
Febrile neutropenia 193.10 11.05 81 104938 121768 31470557
Psychotic disorder 191.78 11.05 298 104721 21995 31570330
Intentional product misuse 190.16 11.05 401 104618 37550 31554775
Drug dependence 188.93 11.05 298 104721 22281 31570044
Cardio-respiratory arrest 179.01 11.05 473 104546 51253 31541072
Sedation 170.85 11.05 259 104760 18706 31573619
Intentional self-injury 168.20 11.05 214 104805 13101 31579224
Status epilepticus 166.42 11.05 203 104816 11903 31580422
Abnormal behaviour 165.18 11.05 289 104730 23539 31568786
Anaemia 163.27 11.05 286 104733 213236 31379089
Drug withdrawal syndrome 157.60 11.05 248 104771 18502 31573823
Psychiatric decompensation 155.08 11.05 91 104928 1885 31590440
Altered state of consciousness 154.68 11.05 262 104757 20789 31571536
Substance abuse 152.32 11.05 151 104868 7007 31585318
Acute kidney injury 146.29 11.05 459 104560 279255 31313070
Depressed level of consciousness 144.89 11.05 364 104655 38237 31554088
Paranoia 133.88 11.05 170 104849 10385 31581940
Dyspnoea 130.26 11.05 641 104378 342838 31249487
Panic attack 126.26 11.05 150 104869 8553 31583772
Loss of personal independence in daily activities 122.53 11.05 282 104737 28006 31564319
Dyskinesia 117.80 11.05 232 104787 20678 31571647
Interstitial lung disease 116.16 11.05 30 104989 61373 31530952
Insomnia 111.98 11.05 614 104405 94222 31498103
Malignant neoplasm progression 109.20 11.05 63 104956 78935 31513390
Diarrhoea 108.97 11.05 703 104316 351706 31240619
Hallucination 108.00 11.05 369 104650 46041 31546284
Pancytopenia 102.86 11.05 83 104936 87233 31505092
Speech disorder 102.33 11.05 239 104780 23962 31568363
Depression suicidal 99.29 11.05 64 104955 1576 31590749
Thrombocytopenia 97.76 11.05 204 104815 142543 31449782
Bradykinesia 96.01 11.05 86 104933 3506 31588819
Ataxia 94.35 11.05 160 104859 12703 31579622
Parkinsonism 93.71 11.05 121 104898 7515 31584810
Dystonia 92.58 11.05 140 104879 10085 31582240
Mydriasis 91.88 11.05 111 104908 6441 31585884
Cardiac arrest 91.65 11.05 556 104463 88506 31503819
Sepsis 91.24 11.05 233 104786 151696 31440629
Psychomotor skills impaired 89.84 11.05 78 104941 3049 31589276
Tearfulness 87.62 11.05 63 104956 1864 31590461
Salivary hypersecretion 84.16 11.05 116 104903 7676 31584649
Delusion 83.75 11.05 146 104873 11851 31580474
Restlessness 83.17 11.05 216 104803 23145 31569180
Pneumonia 82.50 11.05 713 104306 334599 31257726
Disease progression 81.66 11.05 108 104911 90356 31501969
Epilepsy 81.64 11.05 201 104818 20840 31571485
Pneumonia aspiration 81.56 11.05 298 104721 38428 31553897
On and off phenomenon 80.32 11.05 62 104957 2048 31590277
Drug use disorder 79.19 11.05 81 104938 3902 31588423
Serotonin syndrome 76.75 11.05 183 104836 18590 31573735
Rash 76.71 11.05 375 104644 201111 31391214
Bradyphrenia 75.90 11.05 83 104936 4321 31588004
Depressive symptom 75.89 11.05 60 104959 2054 31590271
Granulocytopenia 75.40 11.05 97 104922 6002 31586323
Platelet count decreased 74.58 11.05 159 104860 110276 31482049
Drug withdrawal convulsions 74.24 11.05 47 104972 1121 31591204
Muscle rigidity 73.77 11.05 124 104895 9773 31582552
Renal failure 73.35 11.05 190 104829 123140 31469185
Cardiac failure 73.19 11.05 107 104912 85846 31506479
Victim of crime 72.80 11.05 32 104987 348 31591977
Psychomotor hyperactivity 72.13 11.05 115 104904 8672 31583653
Bradypnoea 72.10 11.05 63 104956 2484 31589841
Pyrexia 71.20 11.05 654 104365 303186 31289139
Atrial fibrillation 71.00 11.05 171 104848 113612 31478713
Irritability 69.86 11.05 200 104819 22689 31569636
Akathisia 69.52 11.05 102 104917 7151 31585174
Hyperkalaemia 68.75 11.05 67 104952 64284 31528041
Plasma cell myeloma 67.48 11.05 53 104966 56478 31535847
Tremor 65.67 11.05 456 104563 75964 31516361
Myocardial infarction 65.02 11.05 178 104841 113276 31479049
Renal impairment 64.61 11.05 117 104902 86232 31506093
Prescribed overdose 64.34 11.05 112 104907 9080 31583245
General physical health deterioration 63.50 11.05 180 104839 113255 31479070
Thinking abnormal 63.26 11.05 85 104934 5488 31586837
Disturbance in attention 62.63 11.05 190 104829 22260 31570065
Cognitive disorder 62.24 11.05 203 104816 24720 31567605
Stoma site discharge 62.05 11.05 39 104980 918 31591407
Neutropenia 61.99 11.05 247 104772 140117 31452208
Catatonia 61.78 11.05 78 104941 4736 31587589
Hallucination, auditory 60.84 11.05 117 104902 10243 31582082
Gastrointestinal haemorrhage 60.74 11.05 113 104906 82436 31509889
Anger 60.70 11.05 122 104897 11031 31581294
Generalised tonic-clonic seizure 60.67 11.05 174 104845 19757 31572568
Pleural effusion 60.19 11.05 97 104922 74823 31517502
Confusional state 59.74 11.05 690 104329 132644 31459681
Memory impairment 59.23 11.05 267 104752 37863 31554462
Psychomotor retardation 59.04 11.05 63 104956 3189 31589136
Posture abnormal 58.32 11.05 51 104968 2013 31590312
Myoclonus 57.86 11.05 137 104882 13853 31578472
Mental impairment 57.64 11.05 109 104910 9423 31582902
Device interaction 57.64 11.05 31 104988 539 31591786
Device dislocation 57.32 11.05 78 104941 5098 31587227
Gait disturbance 53.92 11.05 440 104579 77055 31515270
Cardiac failure congestive 53.82 11.05 114 104905 79273 31513052
Dysarthria 52.61 11.05 228 104791 31789 31560536
Tardive dyskinesia 51.58 11.05 77 104942 5482 31586843
Drooling 51.04 11.05 57 104962 3038 31589287
Stomatitis 50.94 11.05 34 104985 39404 31552921
Withdrawal syndrome 50.93 11.05 117 104902 11600 31580725
Ascites 50.80 11.05 37 104982 40976 31551349
Joint swelling 50.04 11.05 62 104957 53369 31538956
COVID-19 49.90 11.05 65 104954 54756 31537569
Disorientation 49.80 11.05 218 104801 30526 31561799
Rheumatoid arthritis 49.66 11.05 51 104968 47758 31544567
Haemoglobin decreased 48.64 11.05 200 104819 112475 31479850
Nervousness 48.20 11.05 115 104904 11685 31580640
Myoclonic epilepsy 47.48 11.05 35 104984 1077 31591248
Mania 47.12 11.05 98 104921 9079 31583246
Respiratory depression 46.44 11.05 129 104890 14381 31577944
Middle insomnia 46.23 11.05 77 104942 6022 31586303
Housebound 45.46 11.05 20 104999 218 31592107
Hyperprolactinaemia 44.47 11.05 38 104981 1453 31590872
Behaviour disorder 44.39 11.05 63 104956 4284 31588041
Mental disorder 44.28 11.05 123 104896 13711 31578614
Unresponsive to stimuli 44.14 11.05 186 104833 25614 31566711
Hallucination, visual 43.42 11.05 133 104886 15661 31576664
Loss of consciousness 43.38 11.05 419 104600 76936 31515389
Multiple-drug resistance 42.93 11.05 63 104956 4417 31587908
Mucosal inflammation 42.71 11.05 31 104988 34396 31557929
Fall 42.70 11.05 859 104160 185230 31407095
Acute myocardial infarction 42.53 11.05 64 104955 50759 31541566
Drug abuser 42.25 11.05 58 104961 3822 31588503
Urticaria 42.06 11.05 79 104940 57438 31534887
Dyspnoea exertional 41.98 11.05 40 104979 38797 31553528
Prostate cancer 41.50 11.05 38 104981 37563 31554762
Cytomegalovirus infection 41.43 11.05 15 105004 24692 31567633
Drug ineffective 41.13 11.05 1650 103369 393923 31198402
Blood creatinine increased 41.05 11.05 154 104865 88924 31503401
Cerebrovascular accident 40.96 11.05 131 104888 79353 31512972
Infusion related reaction 40.71 11.05 60 104959 47995 31544330
Cerebral haemorrhage 40.12 11.05 30 104989 32782 31559543
Stoma site erythema 40.06 11.05 26 104993 648 31591677
Abnormal dreams 38.98 11.05 78 104941 7030 31585295
Nausea 38.89 11.05 753 104266 307194 31285131
Decreased appetite 38.77 11.05 323 104696 152894 31439431
Angioedema 38.27 11.05 33 104986 33585 31558740
Lactic acidosis 38.03 11.05 30 104989 31907 31560418
Bone marrow failure 37.74 11.05 23 104996 27985 31564340
Oedema peripheral 37.48 11.05 212 104807 109627 31482698
Drug diversion 37.05 11.05 27 104992 816 31591509
Infection 36.88 11.05 143 104876 81788 31510537
Accidental death 36.85 11.05 41 104978 2176 31590149
Contraindicated product administered 36.73 11.05 10 105009 19762 31572563
Colitis 36.51 11.05 35 104984 33852 31558473
Myelopathy 36.43 11.05 41 104978 2204 31590121
Crying 36.34 11.05 66 104953 5531 31586794
Pneumocystis jirovecii pneumonia 36.30 11.05 8 105011 18243 31574082
Anticonvulsant drug level above therapeutic 35.99 11.05 24 104995 627 31591698
Partial seizures 35.64 11.05 57 104962 4309 31588016
Agoraphobia 35.52 11.05 17 105002 228 31592097
Dystonic tremor 35.23 11.05 16 105003 189 31592136
Screaming 35.22 11.05 32 104987 1329 31590996
Multiple organ dysfunction syndrome 34.72 11.05 113 104906 68090 31524235
Toxicologic test abnormal 34.66 11.05 22 104997 527 31591798
Pruritus 33.90 11.05 259 104760 124908 31467417
Freezing phenomenon 33.89 11.05 31 104988 1299 31591026
Erythema 33.88 11.05 144 104875 80261 31512064
Compartment syndrome 33.83 11.05 43 104976 2628 31589697
Post-anoxic myoclonus 33.64 11.05 9 105010 15 31592310
Arthralgia 33.60 11.05 330 104689 151094 31441231
Disinhibition 33.55 11.05 43 104976 2650 31589675
Myelodysplastic syndrome 33.46 11.05 11 105008 19240 31573085
Coronary artery disease 33.08 11.05 64 104955 46023 31546302
Obsessive-compulsive disorder 33.06 11.05 59 104960 4878 31587447
Encephalitis toxic 32.92 11.05 17 105002 271 31592054
Blood creatine phosphokinase increased 32.86 11.05 245 104774 41729 31550596
Accidental overdose 32.72 11.05 134 104885 18216 31574109
Septic shock 32.72 11.05 111 104908 66047 31526278
Melaena 32.60 11.05 36 104983 32618 31559707
Anaphylactic reaction 32.45 11.05 30 104989 29523 31562802
Product substitution issue 32.33 11.05 86 104933 9346 31582979
Psychogenic seizure 32.05 11.05 18 105001 342 31591983
Electroencephalogram abnormal 31.56 11.05 39 104980 2316 31590009
Bronchopulmonary aspergillosis 31.48 11.05 4 105015 13630 31578695
Hypertonia 31.29 11.05 51 104968 3917 31588408
Withdrawal arrhythmia 31.17 11.05 10 105009 40 31592285
Illness anxiety disorder 31.16 11.05 14 105005 161 31592164
Feeling abnormal 31.08 11.05 307 104712 56695 31535630
Drug screen positive 31.05 11.05 50 104969 3802 31588523
Drug intolerance 31.02 11.05 80 104939 51953 31540372
Blood creatine phosphokinase 30.84 11.05 12 105007 93 31592232
Myelosuppression 30.79 11.05 6 105013 14914 31577411
Meconium aspiration syndrome 30.79 11.05 10 105009 42 31592283
Movement disorder 30.49 11.05 93 104926 10926 31581399
Neuropathy peripheral 30.35 11.05 138 104881 75511 31516814
Cough 30.24 11.05 293 104726 134521 31457804
Proteinuria 30.17 11.05 9 105010 16754 31575571
Feeling of despair 30.14 11.05 25 104994 917 31591408
Haematuria 30.14 11.05 68 104951 46246 31546079
Brain scan abnormal 30.04 11.05 24 104995 834 31591491
Restless legs syndrome 29.98 11.05 74 104945 7682 31584643
Cytokine release syndrome 29.84 11.05 9 105010 16633 31575692
Postmortem blood drug level abnormal 29.71 11.05 16 105003 279 31592046
Postmortem blood drug level increased 29.62 11.05 15 105004 229 31592096
Bipolar disorder 29.55 11.05 48 104971 3676 31588649
Generalised anxiety disorder 29.40 11.05 22 104997 693 31591632
Drug hypersensitivity 29.38 11.05 132 104887 72467 31519858
Drug screen negative 28.97 11.05 13 105006 149 31592176
Cerebral infarction 28.96 11.05 26 104993 25951 31566374
Delirium 28.69 11.05 235 104784 41186 31551139
Schizophrenia 28.66 11.05 90 104929 10740 31581585
Sleep apnoea syndrome 28.60 11.05 130 104889 18495 31573830
Acute myeloid leukaemia 28.60 11.05 13 105006 18659 31573666
Excessive eye blinking 28.50 11.05 19 105000 496 31591829
Torticollis 28.49 11.05 26 104993 1086 31591239
Psoriasis 28.49 11.05 71 104948 46648 31545677
Poor quality sleep 28.36 11.05 72 104947 7606 31584719
Vessel puncture site erythema 28.28 11.05 6 105013 0 31592325
Cerebral artery thrombosis 28.13 11.05 22 104997 741 31591584
Hypothermia 27.77 11.05 82 104937 9462 31582863
Neutropenic sepsis 27.71 11.05 4 105015 12375 31579950
Haematochezia 27.50 11.05 58 104961 40406 31551919
Balance disorder 27.38 11.05 215 104804 37207 31555118
Medication error 27.19 11.05 148 104871 22624 31569701
Failure to suspend medication 26.94 11.05 17 105002 403 31591922
Red cell distribution width decreased 26.86 11.05 13 105006 179 31592146
Coordination abnormal 26.78 11.05 68 104951 7183 31585142
Affect lability 26.60 11.05 44 104975 3421 31588904
Panic disorder 26.40 11.05 26 104993 1196 31591129
Purpura fulminans 26.21 11.05 10 105009 73 31592252
Hyperammonaemia 26.18 11.05 59 104960 5774 31586551
Reduced facial expression 26.18 11.05 22 104997 822 31591503
Choreoathetosis 26.17 11.05 24 104995 1009 31591316
Dysphoria 26.00 11.05 34 104985 2138 31590187
Basal cell carcinoma 25.81 11.05 14 105005 18165 31574160
Thrombosis 25.71 11.05 71 104948 45080 31547245
Treatment failure 25.65 11.05 61 104958 40731 31551594
Amnesia 25.24 11.05 148 104871 23254 31569071
Aspergillus infection 25.17 11.05 4 105015 11524 31580801
International normalised ratio increased 25.10 11.05 72 104947 45151 31547174
Haemorrhage 25.08 11.05 77 104942 47257 31545068
Depressed mood 25.02 11.05 120 104899 17455 31574870
Hypertension 24.45 11.05 289 104730 127811 31464514
Bacteraemia 24.43 11.05 14 105005 17620 31574705
Extrapyramidal disorder 24.25 11.05 90 104929 11688 31580637
Gastrointestinal hypermotility 24.22 11.05 11 105008 130 31592195
Blood bilirubin increased 24.18 11.05 50 104969 35086 31557239
Electrocardiogram QRS complex prolonged 23.90 11.05 47 104972 4182 31588143
Gambling disorder 23.88 11.05 28 104991 1574 31590751
Brain injury 23.88 11.05 57 104962 5793 31586532
Hypomagnesaemia 23.85 11.05 17 105002 19041 31573284
Talipes 23.83 11.05 30 104989 1816 31590509
Tubulointerstitial nephritis 23.80 11.05 16 105003 18480 31573845
Dehydration 23.79 11.05 266 104753 118845 31473480
Vomiting 23.74 11.05 563 104456 223410 31368915
Pulmonary fibrosis 23.41 11.05 13 105006 16647 31575678
Hypotonia 23.40 11.05 64 104955 7069 31585256
Feeling guilty 23.15 11.05 14 105005 307 31592018
Somnambulism 22.96 11.05 37 104982 2815 31589510
Atonic seizures 22.69 11.05 13 105006 257 31592068
Gaze palsy 22.57 11.05 26 104993 1434 31590891
Blunted affect 22.56 11.05 14 105005 322 31592003
Pulmonary embolism 22.06 11.05 169 104850 81477 31510848
Peripheral swelling 22.05 11.05 133 104886 67732 31524593
Drug tolerance 22.02 11.05 34 104985 2493 31589832
Palmar-plantar erythrodysaesthesia syndrome 21.87 11.05 12 105007 15471 31576854
Muscle contracture 21.83 11.05 23 104996 1147 31591178
Intensive care unit acquired weakness 21.78 11.05 21 104998 941 31591384
Wrong patient received product 21.70 11.05 34 104985 2525 31589800
Exposure via ingestion 21.64 11.05 30 104989 1995 31590330
Cytopenia 21.55 11.05 5 105014 11005 31581320
Cogwheel rigidity 21.54 11.05 24 104995 1276 31591049
Epistaxis 21.52 11.05 98 104921 53609 31538716
Testicular infarction 21.50 11.05 8 105011 54 31592271
Hepatotoxicity 21.49 11.05 19 105000 19107 31573218
Arthritis 21.47 11.05 36 104983 27349 31564976
Asthenia 21.39 11.05 574 104445 224181 31368144
Sleep-related eating disorder 21.30 11.05 13 105006 290 31592035
Parasomnia 21.25 11.05 14 105005 358 31591967
Stereotypy 21.25 11.05 18 105001 680 31591645
Physical assault 21.17 11.05 22 104997 1080 31591245
Tachyphrenia 21.08 11.05 23 104996 1194 31591131
Thrombotic microangiopathy 20.98 11.05 3 105016 9348 31582977
Sedation complication 20.92 11.05 25 104994 1434 31590891
Congenital melanocytic naevus 20.81 11.05 6 105013 15 31592310
Haematemesis 20.79 11.05 33 104986 25620 31566705
Laboratory test abnormal 20.77 11.05 19 105000 18795 31573530
Drug level above therapeutic 20.69 11.05 41 104978 3669 31588656
COVID-19 pneumonia 20.68 11.05 8 105011 12647 31579678
Liver disorder 20.67 11.05 42 104977 29665 31562660
Tooth injury 20.64 11.05 22 104997 1112 31591213
Neoplasm progression 20.62 11.05 22 104997 20250 31572075
Nephropathy toxic 20.61 11.05 6 105013 11347 31580978
Clonic convulsion 20.60 11.05 17 105002 619 31591706
Personality disorder 20.59 11.05 22 104997 1115 31591210
Ehlers-Danlos syndrome 20.57 11.05 7 105012 35 31592290
Angina pectoris 20.55 11.05 42 104977 29599 31562726
Stoma site inflammation 20.51 11.05 15 105004 456 31591869
Tension 20.43 11.05 29 104990 1972 31590353
Osteonecrosis of jaw 20.36 11.05 16 105003 17055 31575270
Nightmare 20.36 11.05 87 104932 12050 31580275
Obsessive-compulsive personality disorder 20.33 11.05 10 105009 143 31592182
Tumour lysis syndrome 20.22 11.05 13 105006 15372 31576953
Dysmetria 20.03 11.05 15 105004 473 31591852
Injection site exfoliation 20.02 11.05 6 105013 18 31592307
Weight increased 20.01 11.05 386 104633 82561 31509764
Psychotic behaviour 20.01 11.05 17 105002 645 31591680
Chills 19.79 11.05 154 104865 73996 31518329
Dopamine dysregulation syndrome 19.72 11.05 13 105006 333 31591992
Parkinsonian gait 19.71 11.05 15 105004 485 31591840
Hepatic cirrhosis 19.59 11.05 14 105005 15660 31576665
Upper gastrointestinal haemorrhage 19.57 11.05 29 104990 23154 31569171
Phaeochromocytoma malignant 19.52 11.05 8 105011 72 31592253
Hypomania 19.38 11.05 30 104989 2205 31590120
Hyperchloraemia 19.30 11.05 14 105005 420 31591905
Post-traumatic stress disorder 19.30 11.05 26 104993 1683 31590642
Shock haemorrhagic 19.18 11.05 5 105014 10172 31582153
Language disorder 19.12 11.05 29 104990 2094 31590231
Injection site dryness 19.11 11.05 6 105013 22 31592303
Blood prolactin increased 18.78 11.05 25 104994 1599 31590726
Antidepressant drug level increased 18.72 11.05 9 105010 122 31592203
Developmental delay 18.57 11.05 32 104987 2573 31589752
Myalgia 18.56 11.05 165 104854 77093 31515232
Accidental poisoning 18.55 11.05 17 105002 714 31591611
Autonomic nervous system imbalance 18.50 11.05 31 104988 2436 31589889
Stoma site infection 18.41 11.05 17 105002 721 31591604
Postictal paralysis 18.32 11.05 11 105008 238 31592087
Stoma site extravasation 18.12 11.05 8 105011 88 31592237
Haemophagocytic lymphohistiocytosis 18.09 11.05 8 105011 11670 31580655
Areflexia 18.02 11.05 33 104986 2783 31589542
Sleep disorder 17.98 11.05 149 104870 26199 31566126
Major depression 17.96 11.05 42 104977 4211 31588114
Road traffic accident 17.92 11.05 104 104915 16277 31576048
Rapid eye movement sleep behaviour disorder 17.80 11.05 9 105010 137 31592188
Physical abuse 17.79 11.05 5 105014 11 31592314
Postmortem blood drug level 17.74 11.05 9 105010 138 31592187
HIV peripheral neuropathy 17.63 11.05 6 105013 30 31592295
Adrenal insufficiency 17.61 11.05 10 105009 12649 31579676
Postoperative respiratory failure 17.50 11.05 8 105011 96 31592229
Electrocardiogram QT shortened 17.40 11.05 9 105010 144 31592181
Hypersomnia 17.36 11.05 78 104941 11041 31581284
Squamous cell carcinoma of skin 17.36 11.05 6 105013 10168 31582157
Petit mal epilepsy 17.33 11.05 33 104986 2867 31589458
Bruxism 17.20 11.05 24 104995 1606 31590719
Death 17.16 11.05 999 104020 359570 31232755
Rhabdomyolysis 17.12 11.05 301 104718 63280 31529045
Substance use disorder 17.08 11.05 14 105005 505 31591820
Pulmonary hypertension 16.99 11.05 25 104994 20016 31572309
Cholangitis 16.93 11.05 3 105016 7983 31584342
Persecutory delusion 16.90 11.05 29 104990 2323 31590002
Cluster headache 16.82 11.05 14 105005 516 31591809
Colitis ulcerative 16.82 11.05 22 104997 18507 31573818
Developmental regression 16.72 11.05 6 105013 36 31592289
Personality change 16.71 11.05 44 104975 4751 31587574
Antipsychotic drug level increased 16.68 11.05 36 104983 3422 31588903
Stoma site hypergranulation 16.66 11.05 9 105010 158 31592167
Erectile dysfunction 16.63 11.05 115 104904 19120 31573205
Terminal insomnia 16.62 11.05 13 105006 438 31591887
Chronic kidney disease 16.62 11.05 67 104952 37908 31554417
Bradycardia 16.51 11.05 322 104697 69005 31523320
Suicidal behaviour 16.50 11.05 22 104997 1410 31590915
Lymphadenopathy 16.47 11.05 39 104980 26082 31566243
Opsoclonus myoclonus 16.44 11.05 7 105012 70 31592255
Graft versus host disease 16.43 11.05 7 105012 10440 31581885
Poverty of speech 16.43 11.05 10 105009 222 31592103
Apathy 16.36 11.05 53 104966 6429 31585896
Oedema 16.26 11.05 79 104940 42482 31549843
Muscle twitching 16.20 11.05 62 104957 8168 31584157
Cholestasis 16.16 11.05 37 104982 25038 31567287
Homicidal ideation 16.12 11.05 30 104989 2561 31589764
Impulsive behaviour 16.05 11.05 26 104993 1987 31590338
Off label use 16.01 11.05 965 104054 346309 31246016
Atrial flutter 15.94 11.05 15 105004 14640 31577685
Renal hypertension 15.93 11.05 9 105010 173 31592152
Tuberculosis 15.91 11.05 4 105015 8337 31583988
Pseudomonas infection 15.87 11.05 9 105010 11392 31580933
Hypokalaemia 15.86 11.05 108 104911 53466 31538859
Wrong patient 15.84 11.05 9 105010 175 31592150
Haemorrhage intracranial 15.77 11.05 16 105003 15072 31577253
Infantile spasms 15.76 11.05 11 105008 310 31592015
Priapism 15.70 11.05 42 104977 4578 31587747
Spinal shock 15.70 11.05 6 105013 44 31592281
Rash pruritic 15.69 11.05 35 104984 23903 31568422
Inflammation 15.66 11.05 38 104981 25203 31567122
Depersonalisation/derealisation disorder 15.60 11.05 14 105005 572 31591753
Nystagmus 15.56 11.05 41 104978 4429 31587896
Pneumothorax 15.43 11.05 20 104999 16890 31575435
Treatment noncompliance 15.31 11.05 141 104878 25543 31566782
Blood bicarbonate decreased 15.30 11.05 28 104991 2360 31589965
Heat stroke 15.28 11.05 17 105002 902 31591423
Embedded device 15.28 11.05 10 105009 253 31592072
Galactorrhoea 15.22 11.05 12 105007 409 31591916
Clostridium difficile infection 15.19 11.05 21 104998 17258 31575067
Bipolar I disorder 15.19 11.05 16 105003 798 31591527
Drug ineffective for unapproved indication 15.16 11.05 106 104913 17684 31574641
Lethargy 15.10 11.05 195 104824 38446 31553879
Myositis 15.10 11.05 9 105010 11085 31581240
Eye movement disorder 15.09 11.05 37 104982 3824 31588501
Arthropathy 15.09 11.05 36 104983 24015 31568310
Asterixis 15.05 11.05 19 105000 1153 31591172
Brain oedema 15.05 11.05 83 104936 12749 31579576
Intelligence test abnormal 15.03 11.05 5 105014 23 31592302
Allodynia 14.94 11.05 14 105005 605 31591720
Cardiac failure chronic 14.94 11.05 3 105016 7300 31585025
Diffuse large B-cell lymphoma 14.91 11.05 5 105014 8636 31583689
Abdominal pain 14.85 11.05 369 104650 145583 31446742
Hyperphagia 14.80 11.05 20 104999 1298 31591027
Syncope 14.80 11.05 196 104823 84986 31507339
Oropharyngeal pain 14.77 11.05 54 104965 31429 31560896
Patient uncooperative 14.75 11.05 12 105007 428 31591897
Lennox-Gastaut syndrome 14.74 11.05 6 105013 53 31592272
Aplastic anaemia 14.74 11.05 6 105013 9197 31583128
Libido increased 14.69 11.05 15 105004 721 31591604
Stupor 14.61 11.05 30 104989 2754 31589571
Staphylococcal sepsis 14.56 11.05 6 105013 9131 31583194
Feeling jittery 14.56 11.05 36 104983 3741 31588584
Dementia 14.53 11.05 80 104939 12280 31580045
Change in seizure presentation 14.49 11.05 7 105012 96 31592229
Blepharospasm 14.38 11.05 18 105001 1083 31591242
Hyperglycaemia 14.34 11.05 67 104952 36409 31555916
Psychiatric symptom 14.32 11.05 33 104986 3278 31589047
Anhidrosis 14.30 11.05 7 105012 99 31592226
Herpes zoster 14.28 11.05 56 104963 31937 31560388
Accommodation disorder 14.28 11.05 9 105010 213 31592112
Mental status changes 14.26 11.05 182 104837 35786 31556539
Ejaculation disorder 14.25 11.05 17 105002 973 31591352
Purpura 14.24 11.05 7 105012 9603 31582722
Panic reaction 14.18 11.05 20 104999 1352 31590973
Gout 14.14 11.05 24 104995 18150 31574175
Eustachian tube disorder 14.14 11.05 3 105016 0 31592325
Anal spasm 14.14 11.05 3 105016 0 31592325
Fatigue 14.14 11.05 939 104080 334267 31258058
Rectal haemorrhage 14.09 11.05 67 104952 36237 31556088
Substance dependence 14.08 11.05 11 105008 370 31591955
Lung neoplasm malignant 14.00 11.05 20 104999 16210 31576115
Swelling 13.89 11.05 70 104949 37288 31555037
Hyperkinesia 13.87 11.05 22 104997 1651 31590674
Bladder cancer 13.87 11.05 17 105002 14708 31577617
Hyperosmolar state 13.85 11.05 11 105008 379 31591946
Sinus tachycardia 13.84 11.05 95 104924 15754 31576571
Multiple sclerosis 13.78 11.05 58 104961 7979 31584346
Labelled drug-drug interaction medication error 13.71 11.05 14 105005 13149 31579176
Weight abnormal 13.70 11.05 13 105006 571 31591754
Drug level increased 13.69 11.05 114 104905 20072 31572253
Staphylococcal bacteraemia 13.68 11.05 4 105015 7544 31584781
Suspected suicide 13.62 11.05 37 104982 4070 31588255
Deep vein thrombosis 13.60 11.05 132 104887 60604 31531721
Spasmodic dysphonia 13.58 11.05 8 105011 167 31592158
Urinary tract discomfort 13.53 11.05 7 105012 112 31592213
Sexual dysfunction 13.47 11.05 47 104972 5921 31586404
Akinesia 13.45 11.05 24 104995 1984 31590341
Central pain syndrome 13.42 11.05 7 105012 114 31592211
Hostility 13.39 11.05 15 105004 802 31591523
Fluid retention 13.38 11.05 40 104979 24762 31567563
Logorrhoea 13.38 11.05 26 104993 2293 31590032
Locomotive syndrome 13.35 11.05 4 105015 12 31592313
Monorchidism 13.35 11.05 4 105015 12 31592313
Wrong schedule 13.33 11.05 8 105011 173 31592152
Pulmonary arterial hypertension 13.32 11.05 8 105011 9813 31582512
Myocarditis 13.31 11.05 76 104943 11824 31580501
Hyperthermia 13.31 11.05 67 104952 9937 31582388
Diverticulitis 13.28 11.05 26 104993 18619 31573706
Brain malformation 13.26 11.05 7 105012 117 31592208
Ammonia abnormal 13.20 11.05 6 105013 71 31592254
Self esteem decreased 13.07 11.05 12 105007 505 31591820
Neurotoxicity 13.03 11.05 21 104998 16205 31576120
Lymphopenia 13.02 11.05 17 105002 14312 31578013
Frustration tolerance decreased 13.00 11.05 26 104993 2342 31589983
Brain hypoxia 12.96 11.05 10 105009 330 31591995
Glossopharyngeal nerve disorder 12.93 11.05 5 105014 38 31592287
Hypocalcaemia 12.93 11.05 34 104985 21944 31570381
Product complaint 12.90 11.05 44 104975 5480 31586845
Dependence 12.90 11.05 17 105002 1077 31591248
Fibroma 12.82 11.05 9 105010 256 31592069
Staphylococcal infection 12.81 11.05 55 104964 30577 31561748
Incorrect route of product administration 12.70 11.05 74 104945 11599 31580726
Congenital cerebral cyst 12.67 11.05 4 105015 15 31592310
Obsessive thoughts 12.64 11.05 13 105006 630 31591695
Haematuria traumatic 12.63 11.05 8 105011 191 31592134
Oesophageal food impaction 12.57 11.05 6 105013 80 31592245
Hyperhidrosis 12.51 11.05 302 104717 67091 31525234
Mumps 12.50 11.05 6 105013 81 31592244
Senile dementia 12.50 11.05 5 105014 42 31592283
Nasal septum deviation 12.50 11.05 16 105003 985 31591340
Blood osmolarity decreased 12.40 11.05 12 105007 540 31591785
Communication disorder 12.39 11.05 26 104993 2424 31589901
Gallbladder polyp 12.34 11.05 10 105009 355 31591970
Confusional arousal 12.28 11.05 4 105015 17 31592308
Substance use 12.19 11.05 12 105007 552 31591773
Quadriparesis 12.13 11.05 19 105000 1411 31590914
Pseudodementia 12.07 11.05 3 105016 3 31592322
Medical device site scab 12.07 11.05 3 105016 3 31592322
Epstein-Barr virus infection 12.04 11.05 4 105015 6949 31585376
Hypothermia neonatal 12.00 11.05 6 105013 89 31592236
Anticonvulsant drug level decreased 11.97 11.05 16 105003 1028 31591297
Stoma site pain 11.92 11.05 12 105007 567 31591758
Rabbit syndrome 11.92 11.05 4 105015 19 31592306
Social avoidant behaviour 11.91 11.05 29 104990 2984 31589341
Disseminated intravascular coagulation 11.91 11.05 32 104987 20505 31571820
Developmental hip dysplasia 11.90 11.05 9 105010 288 31592037
Pneumonia bacterial 11.84 11.05 10 105009 10286 31582039
Urinary incontinence 11.84 11.05 98 104921 17222 31575103
Acute coronary syndrome 11.80 11.05 15 105004 12774 31579551
Dementia with Lewy bodies 11.79 11.05 13 105006 683 31591642
Neurosis 11.72 11.05 7 105012 150 31592175
Skin ulcer 11.69 11.05 31 104988 19954 31572371
Jaundice 11.69 11.05 56 104963 30231 31562094
Diet refusal 11.69 11.05 9 105010 296 31592029
Therapy non-responder 11.65 11.05 65 104954 33746 31558579
Multiple sclerosis relapse 11.60 11.05 74 104945 11973 31580352
Drug eruption 11.59 11.05 27 104992 18160 31574165
Muscle spasticity 11.55 11.05 43 104976 5592 31586733
Inappropriate affect 11.53 11.05 12 105007 590 31591735
Renal injury 11.50 11.05 11 105008 10654 31581671
Somatic delusion 11.43 11.05 6 105013 99 31592226
Post transplant lymphoproliferative disorder 11.42 11.05 3 105016 6073 31586252
Face oedema 11.39 11.05 11 105008 10605 31581720
Agitated depression 11.33 11.05 8 105011 230 31592095
Bulbar palsy 11.30 11.05 8 105011 231 31592094
Hemiparesis 11.29 11.05 20 104999 14874 31577451
Open reduction of fracture 11.28 11.05 6 105013 102 31592223
Drug level decreased 11.26 11.05 49 104970 6841 31585484
Swelling face 11.18 11.05 35 104984 21355 31570970
Dissociative identity disorder 11.15 11.05 4 105015 24 31592301
Cerebellar atrophy 11.13 11.05 11 105008 508 31591817
Pneumonitis 11.08 11.05 58 104961 30594 31561731
Viral upper respiratory tract infection 11.07 11.05 26 104993 2614 31589711

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3273.56 9.97 3943 237612 223192 70463697
Drug abuse 1846.08 9.97 2387 239168 144869 70542020
Toxicity to various agents 1460.33 9.97 3682 237873 378490 70308399
Respiratory arrest 824.16 9.97 967 240588 52966 70633923
Depression 796.37 9.97 1954 239601 197020 70489869
Suicide attempt 753.84 9.97 1128 240427 78382 70608507
Intentional overdose 730.75 9.97 1249 240306 97186 70589703
Somnolence 633.96 9.97 1890 239665 213716 70473173
Cardio-respiratory arrest 601.77 9.97 1163 240392 99514 70587375
Overdose 597.91 9.97 1589 239966 168156 70518733
Sopor 582.83 9.97 622 240933 30645 70656244
Anxiety 563.25 9.97 1840 239715 218490 70468399
Suicidal ideation 481.03 9.97 856 240699 68740 70618149
Seizure 472.54 9.97 1506 240049 176456 70510433
Poisoning 444.69 9.97 463 241092 22159 70664730
Cardiac arrest 441.19 9.97 1371 240184 158463 70528426
Rheumatoid arthritis 437.28 9.97 224 241331 291581 70395308
Psychotic disorder 414.38 9.97 574 240981 37127 70649762
Intentional self-injury 401.73 9.97 517 241038 31133 70655756
Drug withdrawal syndrome 397.49 9.97 523 241032 32192 70654697
Synovitis 396.48 9.97 9 241546 129219 70557670
Neuroleptic malignant syndrome 378.46 9.97 455 241100 25552 70661337
Drug dependence 347.10 9.97 525 241030 36796 70650093
Drug interaction 340.82 9.97 2344 239211 379097 70307792
Agitation 340.52 9.97 886 240669 92489 70594400
Contraindicated product administered 338.98 9.97 33 241522 134579 70552310
Aggression 317.02 9.97 582 240973 47864 70639025
Intentional product misuse 312.83 9.97 777 240778 78818 70608071
Febrile neutropenia 296.85 9.97 163 241392 204155 70482734
Acute kidney injury 295.92 9.97 745 240810 473879 70213010
Coma 278.81 9.97 815 240740 91029 70595860
Abnormal behaviour 268.67 9.97 449 241106 34260 70652629
Anaemia 257.78 9.97 625 240930 402798 70284091
Drug intolerance 255.72 9.97 235 241320 225452 70461437
Panic attack 244.87 9.97 338 241217 21781 70665108
Infusion related reaction 241.73 9.97 191 241364 197343 70489546
Depressed level of consciousness 241.03 9.97 750 240805 86681 70600208
Tremor 226.61 9.97 1090 240465 154534 70532355
Miosis 223.89 9.97 258 241297 13843 70673046
Hand deformity 223.60 9.97 19 241536 86463 70600426
Dyskinesia 219.40 9.97 453 241102 40621 70646268
Joint swelling 216.91 9.97 329 241226 252882 70434007
Stubbornness 215.91 9.97 70 241485 282 70686607
Serotonin syndrome 209.31 9.97 451 241104 41663 70645226
Rash 205.05 9.97 968 240587 509594 70177295
Systemic lupus erythematosus 202.30 9.97 49 241506 101853 70585036
Insomnia 196.17 9.97 1342 240213 216464 70470425
Speech disorder 194.72 9.97 490 241065 50090 70636799
Irritability 194.17 9.97 413 241142 37812 70649077
Pericarditis 192.99 9.97 29 241526 84676 70602213
Ataxia 189.99 9.97 308 241247 22909 70663980
Paranoia 186.61 9.97 261 241294 17027 70669862
Schizophrenia 185.26 9.97 256 241299 16512 70670377
Sedation 181.24 9.97 454 241101 46277 70640612
Arthropathy 178.67 9.97 149 241406 149908 70536981
Status epilepticus 177.55 9.97 308 241247 24218 70662671
General physical health deterioration 176.08 9.97 335 241220 235696 70451193
Mydriasis 174.56 9.97 244 241311 15909 70670980
Thinking abnormal 170.68 9.97 208 241347 11843 70675046
Dystonia 164.77 9.97 264 241291 19442 70667447
Drug withdrawal convulsions 163.64 9.97 98 241457 2050 70684839
Glossodynia 163.26 9.97 46 241509 86441 70600448
Thrombocytopenia 162.54 9.97 358 241197 238752 70448137
Treatment failure 159.76 9.97 153 241402 143989 70542900
Helicobacter infection 159.52 9.97 7 241548 55649 70631240
Substance abuse 156.19 9.97 180 241375 9657 70677232
Stomatitis 152.49 9.97 128 241427 128383 70558506
Hypersensitivity 152.18 9.97 349 241206 229463 70457426
Sepsis 151.18 9.97 385 241170 244160 70442729
Unresponsive to stimuli 149.14 9.97 452 241103 51479 70635410
Diarrhoea 148.32 9.97 1833 239722 781508 69905381
Neutropenia 145.37 9.97 423 241132 256733 70430156
Restless legs syndrome 144.75 9.97 240 241315 18188 70668701
Interstitial lung disease 144.16 9.97 89 241466 104596 70582293
Withdrawal syndrome 144.12 9.97 284 241271 24620 70662269
Tardive dyskinesia 143.26 9.97 173 241382 9756 70677133
Pancytopenia 142.63 9.97 183 241372 150924 70535965
Psychiatric decompensation 141.03 9.97 101 241454 2886 70684003
Altered state of consciousness 140.94 9.97 375 241180 39647 70647242
Muscle rigidity 139.98 9.97 238 241317 18412 70668477
Rheumatoid factor positive 139.01 9.97 6 241549 48394 70638495
Hypomania 137.12 9.97 134 241421 5938 70680951
Infection 136.43 9.97 324 241231 210461 70476428
Mental disorder 136.41 9.97 299 241256 27941 70658948
Hallucination 136.40 9.97 568 240987 75692 70611197
Drug hypersensitivity 136.11 9.97 449 241106 262010 70424879
Atrial fibrillation 135.39 9.97 264 241291 184084 70502805
Alopecia 135.02 9.97 297 241258 198193 70488696
Malignant neoplasm progression 132.84 9.97 131 241424 121608 70565281
Mania 131.33 9.97 221 241334 16953 70669936
Disease progression 130.79 9.97 207 241348 156465 70530424
Akathisia 130.32 9.97 184 241371 12109 70674780
Swelling 129.15 9.97 281 241274 188258 70498631
Bradyphrenia 128.58 9.97 164 241391 9782 70677107
Disturbance in attention 127.57 9.97 378 241177 42516 70644373
Granulocytopenia 125.88 9.97 168 241387 10479 70676410
Epilepsy 123.26 9.97 350 241205 38434 70648455
Feeling of despair 121.42 9.97 88 241467 2563 70684326
Restlessness 121.27 9.97 367 241188 41761 70645128
Drooling 117.25 9.97 117 241438 5319 70681570
Sensitisation 115.34 9.97 83 241472 2390 70684499
Generalised tonic-clonic seizure 114.40 9.97 357 241198 41304 70645585
Crying 113.42 9.97 234 241321 20965 70665924
Dyspnoea 110.95 9.97 1901 239654 768159 69918730
Polycystic ovaries 110.75 9.97 86 241469 2786 70684103
Impaired healing 109.87 9.97 58 241497 74316 70612573
Bradykinesia 108.71 9.97 131 241424 7371 70679518
Anger 108.27 9.97 196 241359 15936 70670953
Wound 107.99 9.97 106 241449 98626 70588263
Arthralgia 107.87 9.97 1145 240410 502245 70184644
Parkinsonism 107.73 9.97 190 241365 15135 70671754
Pleural effusion 107.64 9.97 179 241376 132685 70554204
Pneumonia aspiration 107.53 9.97 459 241096 61830 70625059
Renal impairment 107.52 9.97 204 241351 143733 70543156
Memory impairment 107.19 9.97 609 240946 92032 70594857
Platelet count decreased 106.72 9.97 285 241270 177937 70508952
Gastrointestinal haemorrhage 105.96 9.97 191 241364 137217 70549672
Cardiac failure 105.86 9.97 205 241350 143336 70543553
Mood altered 104.07 9.97 195 241360 16280 70670609
Hyperkalaemia 103.80 9.97 126 241429 106465 70580424
Drug use disorder 103.16 9.97 133 241422 8018 70678871
Dysarthria 100.58 9.97 450 241105 61863 70625026
Lactic acidosis 100.12 9.97 48 241507 64976 70621913
Abdominal discomfort 99.42 9.97 385 241170 214273 70472616
Ejection fraction 98.26 9.97 66 241489 1696 70685193
On and off phenomenon 97.93 9.97 79 241476 2707 70684182
Respiratory depression 97.06 9.97 242 241313 24589 70662300
Hallucination, auditory 96.52 9.97 201 241354 18127 70668762
Folliculitis 95.98 9.97 15 241540 42555 70644334
Plasma cell myeloma 95.65 9.97 66 241489 73135 70613754
Cogwheel rigidity 95.62 9.97 80 241475 2888 70684001
Maternal exposure during pregnancy 91.04 9.97 158 241397 115187 70571702
Loss of consciousness 89.74 9.97 867 240688 154849 70532040
Psychomotor hyperactivity 88.09 9.97 175 241380 15258 70671631
Gait disturbance 86.60 9.97 988 240567 184118 70502771
Therapeutic product effect decreased 86.14 9.97 228 241327 142790 70544099
Salivary hypersecretion 85.43 9.97 156 241399 12769 70674120
Peripheral swelling 84.77 9.97 466 241089 236097 70450792
Hepatic enzyme increased 84.51 9.97 264 241291 156726 70530163
Lower respiratory tract infection 84.11 9.97 158 241397 111755 70575134
Bone marrow failure 83.76 9.97 31 241524 48979 70637910
Catatonia 83.65 9.97 120 241435 8013 70678876
Middle insomnia 83.42 9.97 162 241393 13891 70672998
Pyrexia 83.22 9.97 1511 240044 605441 70081448
Off label use 83.17 9.97 1913 239642 741147 69945742
Delusion 82.64 9.97 194 241361 18971 70667918
Disorientation 82.25 9.97 403 241152 57520 70629369
Gastric pH decreased 81.76 9.97 44 241511 744 70686145
Feeling abnormal 80.33 9.97 789 240766 141530 70545359
Mucosal inflammation 79.95 9.97 68 241487 67782 70619107
Drug abuser 79.47 9.97 99 241456 5765 70681124
Balance disorder 79.03 9.97 552 241003 89576 70597313
Nightmare 78.40 9.97 208 241347 21948 70664941
Renal failure 78.30 9.97 354 241201 188716 70498173
Blood creatinine increased 78.01 9.97 239 241316 142762 70544127
Hyperhidrosis 77.47 9.97 736 240819 130850 70556039
Myocardial infarction 77.45 9.97 311 241244 171334 70515555
Muscle injury 77.38 9.97 18 241537 38476 70648413
Victim of crime 76.78 9.97 35 241520 405 70686484
Cardiac failure congestive 75.61 9.97 224 241331 135233 70551656
Hyperprolactinaemia 75.59 9.97 84 241471 4329 70682560
Cytomegalovirus infection 75.29 9.97 21 241534 39737 70647152
Depression suicidal 75.28 9.97 69 241486 2818 70684071
Myelosuppression 74.27 9.97 8 241547 30137 70656752
Bipolar disorder 73.53 9.97 109 241446 7499 70679390
Melaena 73.38 9.97 51 241504 56304 70630585
Derealisation 72.66 9.97 52 241503 1484 70685405
Dissociation 71.59 9.97 72 241483 3304 70683585
Tearfulness 70.04 9.97 86 241469 4934 70681955
Myoclonus 69.74 9.97 223 241332 26132 70660757
Hypersomnia 69.53 9.97 191 241364 20573 70666316
Psychomotor skills impaired 69.04 9.97 79 241476 4205 70682684
Exposure via ingestion 68.25 9.97 84 241471 4831 70682058
Stoma site discharge 68.01 9.97 53 241502 1726 70685163
Anticonvulsant drug level above therapeutic 67.02 9.97 44 241511 1087 70685802
Amnesia 65.76 9.97 351 241204 51804 70635085
Multiple sclerosis relapse 65.21 9.97 305 241250 42712 70644177
Nervousness 64.66 9.97 243 241312 30877 70656012
Mood swings 64.03 9.97 171 241384 18115 70668774
Septic shock 63.83 9.97 184 241371 112074 70574815
Discomfort 63.54 9.97 168 241387 105268 70581621
Electrocardiogram QRS complex prolonged 63.10 9.97 117 241438 9689 70677200
Emotional disorder 62.70 9.97 139 241416 13087 70673802
Angioedema 62.48 9.97 81 241474 66529 70620360
Ascites 62.47 9.97 83 241472 67464 70619425
Depersonalisation/derealisation disorder 62.36 9.97 50 241505 1698 70685191
Electroencephalogram abnormal 62.21 9.97 83 241472 5175 70681714
Movement disorder 60.99 9.97 201 241354 23928 70662961
Multiple-drug resistance 60.75 9.97 98 241457 7257 70679632
Pneumocystis jirovecii pneumonia 60.60 9.97 14 241541 30068 70656821
Sleep disorder due to general medical condition, insomnia type 60.39 9.97 23 241532 35709 70651180
Haemoglobin decreased 60.11 9.97 430 241125 204729 70482160
Depressive symptom 60.10 9.97 81 241474 5100 70681789
Multiple sclerosis 59.82 9.97 206 241349 25079 70661810
Loss of personal independence in daily activities 59.27 9.97 493 241062 84417 70602472
Electrocardiogram QT prolonged 58.34 9.97 485 241070 83032 70603857
Psychomotor retardation 58.17 9.97 83 241472 5515 70681374
Sleep apnoea syndrome 57.95 9.97 243 241312 32470 70654419
Rhinitis allergic 57.44 9.97 109 241446 9186 70677703
Mental status changes 57.40 9.97 390 241165 62711 70624178
Myoglobin urine present 57.29 9.97 34 241521 699 70686190
Blood creatine phosphokinase increased 56.54 9.97 380 241175 60883 70626006
Dopamine dysregulation syndrome 55.47 9.97 29 241526 461 70686428
Urticaria 55.24 9.97 327 241228 162722 70524167
Irritable bowel syndrome 55.12 9.97 55 241500 50795 70636094
Feeling of body temperature change 54.97 9.97 76 241479 4903 70681986
Haematochezia 54.18 9.97 104 241451 72977 70613912
Fall 54.07 9.97 1933 239622 442163 70244726
Hypoaesthesia oral 53.56 9.97 125 241430 12175 70674714
Mental impairment 53.15 9.97 154 241401 17101 70669788
Confusional state 52.88 9.97 1305 240250 283093 70403796
Drug screen positive 52.64 9.97 81 241474 5759 70681130
Neuropathy peripheral 51.67 9.97 239 241316 126657 70560232
Neutrophil count decreased 51.21 9.97 132 241423 83424 70603465
Galactorrhoea 50.61 9.97 60 241495 3318 70683571
Red blood cell sedimentation rate abnormal 50.55 9.97 4 241551 19299 70667590
Sleep-related eating disorder 50.54 9.97 31 241524 678 70686211
Acute myocardial infarction 50.39 9.97 108 241447 72779 70614110
Palmar-plantar erythrodysaesthesia syndrome 50.24 9.97 20 241535 30227 70656662
Personality disorder 50.08 9.97 77 241478 5471 70681418
Inflammation 49.98 9.97 122 241433 78543 70608346
Feeling jittery 49.93 9.97 117 241438 11426 70675463
Transplant rejection 49.81 9.97 3 241552 18168 70668721
Colitis 49.80 9.97 88 241467 63726 70623163
Osteonecrosis of jaw 49.65 9.97 40 241515 40962 70645927
C-reactive protein increased 49.36 9.97 201 241354 110316 70576573
Myocardial stunning 48.97 9.97 20 241535 173 70686716
Erythema 48.89 9.97 439 241116 199124 70487765
Urinary tract discomfort 48.55 9.97 26 241529 435 70686454
Breast hyperplasia 48.47 9.97 18 241537 117 70686772
Nasopharyngitis 48.44 9.97 503 241052 221703 70465186
Tension 48.35 9.97 64 241491 3960 70682929
Incontinence 47.82 9.97 124 241431 12904 70673985
Hypercalcaemia 47.64 9.97 29 241526 34356 70652533
Pulmonary fibrosis 47.45 9.97 29 241526 34281 70652608
Upper gastrointestinal haemorrhage 47.37 9.97 35 241520 37442 70649447
Hypertension 47.33 9.97 716 240839 295317 70391572
Neutropenic sepsis 47.23 9.97 13 241542 24817 70662072
Drug screen negative 46.84 9.97 22 241533 274 70686615
Bradypnoea 46.82 9.97 74 241481 5385 70681504
Herpes zoster 46.79 9.97 142 241413 85093 70601796
Hypokinesia 46.58 9.97 148 241407 17284 70669605
Cytokine release syndrome 46.49 9.97 16 241539 26451 70660438
Abnormal dreams 46.44 9.97 108 241447 10495 70676394
Proteinuria 46.27 9.97 21 241534 29353 70657536
Menstrual disorder 46.15 9.97 59 241496 3527 70683362
Sluggishness 46.13 9.97 77 241478 5866 70681023
Stoma site erythema 45.93 9.97 38 241517 1350 70685539
Dysphoria 45.72 9.97 66 241489 4432 70682457
Decorticate posture 45.40 9.97 22 241533 295 70686594
Rheumatic fever 45.31 9.97 4 241551 17656 70669233
Cognitive disorder 45.28 9.97 359 241196 60597 70626292
Housebound 45.21 9.97 25 241530 447 70686442
Prostate cancer 45.00 9.97 25 241530 31138 70655751
Posture abnormal 44.45 9.97 58 241497 3538 70683351
Acute myeloid leukaemia 44.42 9.97 25 241530 30915 70655974
Behaviour disorder 44.03 9.97 72 241483 5392 70681497
Nystagmus 43.98 9.97 98 241457 9257 70677632
Migraine 43.96 9.97 407 241148 71831 70615058
Head injury 43.88 9.97 231 241324 33910 70652979
Myoclonic epilepsy 43.71 9.97 42 241513 1822 70685067
Hallucinations, mixed 43.59 9.97 78 241477 6284 70680605
Rubber sensitivity 43.48 9.97 38 241517 1457 70685432
Toxic encephalopathy 43.41 9.97 104 241451 10302 70676587
Gastrointestinal disorder 43.25 9.97 198 241357 105229 70581660
Musculoskeletal pain 43.07 9.97 160 241395 90167 70596722
Alveolar osteitis 42.87 9.97 26 241529 557 70686332
Multiple organ dysfunction syndrome 42.64 9.97 207 241348 108308 70578581
COVID-19 42.57 9.97 200 241355 105557 70581332
Anaphylactic reaction 42.53 9.97 123 241432 74851 70612038
Pneumonia 42.29 9.97 1632 239923 594600 70092289
Hypothermia 42.11 9.97 160 241395 20434 70666455
Hyperammonaemia 42.01 9.97 102 241453 10191 70676698
Bronchopulmonary aspergillosis 41.86 9.97 10 241545 20992 70665897
Autonomic nervous system imbalance 41.69 9.97 62 241493 4277 70682612
Hypocalcaemia 41.60 9.97 55 241500 44804 70642085
Pruritus 41.53 9.97 879 240676 344681 70342208
Psoriatic arthropathy 41.50 9.97 100 241455 64671 70622218
Panic disorder 41.48 9.97 50 241505 2814 70684075
Myelodysplastic syndrome 41.43 9.97 25 241530 29760 70657129
Neoplasm progression 41.39 9.97 56 241499 45172 70641717
Atonic seizures 41.13 9.97 28 241527 736 70686153
Tumour lysis syndrome 40.97 9.97 11 241544 21349 70665540
Myocardial depression 40.50 9.97 24 241531 492 70686397
Cerebral haemorrhage 40.50 9.97 76 241479 53788 70633101
Hostility 40.49 9.97 44 241511 2211 70684678
Broncholithiasis 40.45 9.97 18 241537 196 70686693
Lethargy 40.41 9.97 413 241142 74837 70612052
Therapeutic product ineffective 40.12 9.97 38 241517 1619 70685270
H1N1 influenza 40.09 9.97 45 241510 2345 70684544
Accidental overdose 40.02 9.97 230 241325 34891 70651998
Libido increased 39.89 9.97 40 241515 1829 70685060
Rash pruritic 39.77 9.97 98 241457 62893 70623996
Muscle twitching 39.69 9.97 153 241402 19674 70667215
Shock haemorrhagic 39.44 9.97 7 241548 18099 70668790
Major depression 39.40 9.97 89 241466 8485 70678404
Depressed mood 39.35 9.97 270 241285 43550 70643339
Delirium 39.35 9.97 408 241147 74206 70612683
Stereotypy 39.29 9.97 29 241526 869 70686020
Toxicologic test abnormal 39.13 9.97 34 241521 1293 70685596
Extrapyramidal disorder 39.01 9.97 157 241398 20593 70666296
Screaming 38.97 9.97 55 241500 3617 70683272
Antipsychotic drug level increased 38.95 9.97 68 241487 5372 70681517
Hypomagnesaemia 38.81 9.97 49 241506 40715 70646174
Oedema peripheral 38.41 9.97 546 241009 227545 70459344
Nausea 38.11 9.97 2447 239108 849641 69837248
Device interaction 38.07 9.97 26 241529 687 70686202
Hallucination, visual 38.05 9.97 199 241356 29138 70657751
Product substitution issue 37.99 9.97 144 241411 18369 70668520
Areflexia 37.95 9.97 65 241490 5057 70681832
Ill-defined disorder 37.93 9.97 81 241474 54660 70632229
Vision blurred 37.86 9.97 492 241063 94492 70592397
Pulmonary arterial hypertension 37.40 9.97 34 241521 32821 70654068
Parosmia 37.09 9.97 63 241492 4868 70682021
Blister 37.08 9.97 196 241359 100330 70586559
Skin ulcer 37.02 9.97 67 241488 48078 70638811
Carpal tunnel syndrome 36.95 9.97 135 241420 16922 70669967
Creatinine renal clearance decreased 36.71 9.97 7 241548 17193 70669696
Aspergillus infection 36.63 9.97 8 241547 17860 70669029
Thrombotic microangiopathy 36.57 9.97 8 241547 17840 70669049
Adjustment disorder with mixed anxiety and depressed mood 36.45 9.97 13 241542 74 70686815
Disinhibition 36.35 9.97 42 241513 2259 70684630
Knee arthroplasty 36.15 9.97 38 241517 34263 70652626
Torticollis 36.05 9.97 41 241514 2168 70684721
Obsessive-compulsive disorder 35.72 9.97 65 241490 5305 70681584
Persecutory delusion 35.70 9.97 59 241496 4458 70682431
Hip arthroplasty 35.68 9.97 26 241529 28014 70658875
Nephrectomy 35.60 9.97 37 241518 1766 70685123
Partial seizures 35.31 9.97 83 241472 8122 70678767
Impaired driving ability 35.15 9.97 61 241494 4796 70682093
Cytopenia 35.02 9.97 8 241547 17315 70669574
Bone erosion 35 9.97 5 241550 15168 70671721
Accidental death 34.94 9.97 54 241501 3854 70683035
Dystonic tremor 34.81 9.97 16 241539 189 70686700
Coronary artery disease 34.80 9.97 104 241451 62632 70624257
Epistaxis 34.12 9.97 207 241348 102420 70584469
Mobility decreased 34.12 9.97 208 241347 102791 70584098
Cerebrovascular accident 34.08 9.97 318 241237 143152 70543737
Coordination abnormal 33.83 9.97 126 241429 15940 70670949
Basal cell carcinoma 33.68 9.97 39 241516 33659 70653230
Weight abnormal 33.52 9.97 32 241523 1377 70685512
Haematuria 33.42 9.97 108 241447 63465 70623424
Libido decreased 33.33 9.97 60 241495 4856 70682033
Hypoventilation 33.28 9.97 71 241484 6511 70680378
Freezing phenomenon 33.10 9.97 34 241521 1600 70685289
Post-anoxic myoclonus 33.05 9.97 11 241544 49 70686840
Incoherent 32.64 9.97 75 241480 7231 70679658
Parasomnia 32.38 9.97 21 241534 508 70686381
Bladder pain 32.37 9.97 37 241518 1967 70684922
Red blood cell sedimentation rate increased 32.27 9.97 51 241504 38591 70648298
Burning sensation 32.23 9.97 298 241257 52572 70634317
Hyponatraemia 32.22 9.97 369 241186 159718 70527171
Hypokalaemia 31.93 9.97 289 241266 130899 70555990
Arthritis 31.86 9.97 199 241356 97781 70589108
Oromandibular dystonia 31.81 9.97 26 241529 908 70685981
Treatment noncompliance 31.74 9.97 269 241286 46305 70640584
Agoraphobia 31.63 9.97 21 241534 529 70686360
Pathogen resistance 31.53 9.97 4 241551 13275 70673614
Aplastic anaemia 31.33 9.97 9 241546 16707 70670182
Adrenal insufficiency 31.24 9.97 24 241531 25171 70661718
Bruxism 31.23 9.97 50 241505 3679 70683210
International normalised ratio increased 31.13 9.97 155 241400 80571 70606318
Anaphylactic shock 30.99 9.97 39 241516 32451 70654438
Prescribed overdose 30.97 9.97 178 241377 27003 70659886
Withdrawal arrhythmia 30.90 9.97 10 241545 40 70686849
Psychogenic seizure 30.62 9.97 35 241520 1861 70685028
Lymph node calcification 30.59 9.97 18 241537 364 70686525
Animal scratch 30.58 9.97 28 241527 1142 70685747
Right ventricular failure 30.56 9.97 19 241536 22255 70664634
Pleurothotonus 30.56 9.97 39 241516 2327 70684562
Gaze palsy 30.54 9.97 42 241513 2696 70684193
Blood test abnormal 30.37 9.97 114 241441 14476 70672413
Bipolar I disorder 30.30 9.97 35 241520 1882 70685007
Tinnitus 30.20 9.97 219 241336 35957 70650932
Haematemesis 29.97 9.97 77 241478 48720 70638169
Drug diversion 29.85 9.97 28 241527 1178 70685711
Affect lability 29.77 9.97 89 241466 10057 70676832
Stoma site hypergranulation 29.46 9.97 18 241537 391 70686498
Encephalitis toxic 29.39 9.97 16 241539 277 70686612
Stoma site pain 29.38 9.97 28 241527 1202 70685687
Tunnel vision 29.36 9.97 28 241527 1203 70685686
Suspected suicide 29.31 9.97 81 241474 8753 70678136
Diffuse large B-cell lymphoma 29.29 9.97 5 241550 13297 70673592
Tubulointerstitial nephritis 29.22 9.97 42 241513 33034 70653855
Cholestasis 29.04 9.97 76 241479 47796 70639093
Sleep disorder due to a general medical condition 28.96 9.97 90 241465 10386 70676503
Therapy non-responder 28.91 9.97 149 241406 76766 70610123
Hyperthermia 28.87 9.97 123 241432 16548 70670341
Impulsive behaviour 28.86 9.97 41 241514 2713 70684176
Weight increased 28.73 9.97 1052 240503 241279 70445610
Jaundice cholestatic 28.32 9.97 82 241473 9102 70677787
Hypertonia 28.25 9.97 66 241489 6432 70680457
Vessel puncture site erythema 28.11 9.97 6 241549 0 70686889
Liver disorder 28.10 9.97 111 241444 61457 70625432
Cerebellar atrophy 28.00 9.97 26 241529 1080 70685809
Rectal haemorrhage 27.98 9.97 122 241433 65709 70621180
Dyspnoea exertional 27.78 9.97 155 241400 78275 70608614
Fear 27.56 9.97 142 241413 20669 70666220
Pulmonary hypertension 27.39 9.97 75 241480 46461 70640428
Feeling guilty 27.31 9.97 23 241532 838 70686051
Apathy 27.29 9.97 96 241459 11812 70675077
Parkinsonian gait 27.24 9.97 23 241532 841 70686048
Urinary retention 27.13 9.97 286 241269 52234 70634655
Bacteraemia 27.11 9.97 36 241519 29273 70657616
Blood creatine phosphokinase 27.10 9.97 12 241543 129 70686760
Coma blister 26.81 9.97 14 241541 222 70686667
Drug level above therapeutic 26.70 9.97 72 241483 7670 70679219
Band neutrophil percentage increased 26.70 9.97 17 241538 398 70686491
Anorgasmia 26.49 9.97 25 241530 1060 70685829
Enthesopathy 26.48 9.97 3 241552 10866 70676023
Hypervolaemia 26.48 9.97 60 241495 39646 70647243
Urinary bladder rupture 26.17 9.97 11 241544 103 70686786
Substance use disorder 25.80 9.97 20 241535 646 70686243
Hypotonia 25.78 9.97 94 241461 11771 70675118
Somnambulism 25.75 9.97 56 241499 5204 70681685
Blood prolactin increased 25.69 9.97 46 241509 3708 70683181
Poor quality sleep 25.68 9.97 137 241418 20212 70666677
Road traffic accident 25.61 9.97 204 241351 34478 70652411
Diverticulitis 25.51 9.97 66 241489 41668 70645221
Heat stroke 25.49 9.97 29 241526 1534 70685355
Emotional distress 25.45 9.97 215 241340 36973 70649916
Stress 25.40 9.97 348 241207 67618 70619271
Seizure cluster 25.30 9.97 16 241539 370 70686519
Stoma site extravasation 25.25 9.97 15 241540 309 70686580
Change in seizure presentation 25.21 9.97 15 241540 310 70686579
Logorrhoea 25.12 9.97 48 241507 4066 70682823
Osteoporosis 25.07 9.97 84 241471 48823 70638066
Tachyphrenia 24.95 9.97 32 241523 1919 70684970
Abdominal pain 24.73 9.97 934 240621 341193 70345696
Post-traumatic neck syndrome 24.67 9.97 32 241523 1941 70684948
Haematotoxicity 24.48 9.97 8 241547 13666 70673223
Jaundice 24.38 9.97 88 241467 50020 70636869
Self-injurious ideation 24.26 9.97 42 241513 3296 70683593
Schizoaffective disorder 24.03 9.97 32 241523 1991 70684898
Oedema 23.99 9.97 231 241324 103350 70583539
Ketosis-prone diabetes mellitus 23.95 9.97 7 241548 18 70686871
Disseminated intravascular coagulation 23.88 9.97 49 241506 33549 70653340
Panic reaction 23.86 9.97 48 241507 4223 70682666
Vomiting 23.81 9.97 1719 239836 591392 70095497
Muscle disorder 23.74 9.97 54 241501 5171 70681718
Secretion discharge 23.63 9.97 97 241458 12836 70674053
Coma scale abnormal 23.63 9.97 71 241484 8045 70678844
Rapid eye movement sleep behaviour disorder 23.60 9.97 15 241540 350 70686539
Ehlers-Danlos syndrome 23.56 9.97 11 241544 135 70686754
Concussion 23.43 9.97 73 241482 8436 70678453
Cerebral infarction 23.35 9.97 72 241483 42937 70643952
Clostridium difficile infection 23.26 9.97 62 241493 38754 70648135
Oropharyngeal oedema 23.23 9.97 15 241540 360 70686529
Muscle spasms 23.20 9.97 688 240867 153358 70533531
Post transplant lymphoproliferative disorder 23.14 9.97 4 241551 10541 70676348
Psychiatric symptom 23.13 9.97 62 241493 6582 70680307
Heart rate increased 23.07 9.97 498 241057 105650 70581239
Failure to suspend medication 23 9.97 16 241539 436 70686453
Brain scan abnormal 22.88 9.97 24 241531 1158 70685731
Drug ineffective for unapproved indication 22.87 9.97 216 241339 38322 70648567
Euphoric mood 22.70 9.97 63 241492 6826 70680063
Liver function test increased 22.69 9.97 51 241504 33796 70653093
Nephropathy toxic 22.49 9.97 18 241537 18496 70668393
Pain 22.33 9.97 1841 239714 626975 70059914
Attention deficit hyperactivity disorder 22.25 9.97 38 241517 2949 70683940
Influenza like illness 22.21 9.97 329 241226 65002 70621887
Impulse-control disorder 22.20 9.97 28 241527 1651 70685238
Cholangitis 22.05 9.97 6 241549 11543 70675346
Lymphopenia 22.01 9.97 37 241518 27322 70659567
Postmortem blood drug level abnormal 21.96 9.97 18 241537 631 70686258
Stupor 21.91 9.97 60 241495 6449 70680440
Squamous cell carcinoma of skin 21.79 9.97 8 241547 12704 70674185
Hyperkinesia 21.73 9.97 35 241520 2588 70684301
Leukopenia 21.68 9.97 245 241310 106315 70580574
Hyperphagia 21.66 9.97 33 241522 2326 70684563
Hyperbilirubinaemia 21.62 9.97 27 241528 22541 70664348
Hyperreflexia 21.57 9.97 65 241490 7377 70679512
Limb injury 21.55 9.97 156 241399 25596 70661293
Accidental poisoning 21.53 9.97 27 241528 1583 70685306
Fluid retention 21.51 9.97 127 241428 63258 70623631
Psychotic disorder due to a general medical condition 21.49 9.97 13 241542 277 70686612
Substance dependence 21.43 9.97 16 241539 488 70686401
Urinary incontinence 21.42 9.97 210 241345 37632 70649257
Kidney transplant rejection 21.37 9.97 4 241551 9957 70676932
Upper respiratory tract infection 21.37 9.97 170 241385 79104 70607785
Abdominal pain upper 21.35 9.97 499 241056 193103 70493786
Dysstasia 21.35 9.97 153 241402 25026 70661863
Testicular infarction 21.29 9.97 8 241547 54 70686835
Blepharospasm 21.22 9.97 43 241512 3802 70683087
Food craving 21.13 9.97 26 241529 1495 70685394
Device dislocation 20.99 9.97 140 241415 22367 70664522
Sinusitis 20.99 9.97 428 241127 168767 70518122
Chronic kidney disease 20.90 9.97 122 241433 60935 70625954
Drug eruption 20.82 9.97 67 241488 39429 70647460
Metastases to liver 20.82 9.97 35 241520 25843 70661046
Encephalopathy 20.76 9.97 310 241245 61351 70625538
Tic 20.67 9.97 35 241520 2698 70684191
Thrombosis 20.65 9.97 161 241394 75244 70611645
Physical assault 20.55 9.97 26 241529 1538 70685351
Post-traumatic stress disorder 20.53 9.97 46 241509 4361 70682528
Onychophagia 20.47 9.97 9 241546 95 70686794
Graft versus host disease 20.36 9.97 13 241542 15010 70671879
White blood cell count decreased 20.34 9.97 433 241122 169708 70517181
Soft tissue injury 20.09 9.97 27 241528 1695 70685194
Rash maculo-papular 20.09 9.97 96 241459 50449 70636440
Paranasal sinus discomfort 20.07 9.97 40 241515 3495 70683394
Hepatic cirrhosis 20.04 9.97 47 241508 30684 70656205
Mutism 20.00 9.97 30 241525 2086 70684803
Acute generalised exanthematous pustulosis 19.95 9.97 14 241541 15383 70671506
Dysphemia 19.84 9.97 38 241517 3225 70683664
Pneumonitis 19.82 9.97 107 241448 54490 70632399
Haematoma 19.81 9.97 91 241464 48327 70638562
Aphasia 19.81 9.97 230 241325 43019 70643870
Atrial flutter 19.81 9.97 24 241531 20303 70666586
Sensory loss 19.58 9.97 84 241471 11335 70675554
Venoocclusive liver disease 19.56 9.97 6 241549 10672 70676217
Blood sodium decreased 19.54 9.97 176 241379 30822 70656067
Postoperative respiratory failure 19.53 9.97 10 241545 152 70686737
Social anxiety disorder 19.47 9.97 15 241540 480 70686409
Head titubation 19.46 9.97 19 241536 841 70686048
Hereditary angioedema 19.45 9.97 49 241506 5010 70681879
Phaeochromocytoma malignant 19.31 9.97 8 241547 72 70686817
Acute coronary syndrome 19.26 9.97 24 241531 20055 70666834
Psychotic behaviour 19.23 9.97 21 241534 1061 70685828
Adverse drug reaction 19.12 9.97 105 241450 53239 70633650
Respiratory rate decreased 19.10 9.97 47 241508 4735 70682154
Gambling disorder 19.06 9.97 28 241527 1910 70684979
Compulsive shopping 18.94 9.97 18 241537 770 70686119
Stoma site infection 18.88 9.97 23 241532 1309 70685580
Purpura fulminans 18.85 9.97 10 241545 164 70686725
Staphylococcal infection 18.66 9.97 106 241449 53298 70633591
Stoma site inflammation 18.63 9.97 16 241539 599 70686290
Hyperchloraemia 18.62 9.97 20 241535 992 70685897
Angina pectoris 18.59 9.97 93 241462 48290 70638599
Obsessive-compulsive personality disorder 18.55 9.97 9 241546 121 70686768
Lupus-like syndrome 18.50 9.97 8 241547 11507 70675382
Liver function test abnormal 18.45 9.97 127 241428 61019 70625870
Generalised anxiety disorder 18.34 9.97 28 241527 1977 70684912
Conversion disorder 18.28 9.97 26 241529 1722 70685167
Colitis ulcerative 18.27 9.97 57 241498 33866 70653023
Haemophagocytic lymphohistiocytosis 18.23 9.97 24 241531 19588 70667301
Tongue discolouration 18.17 9.97 38 241517 3436 70683453
Homicidal ideation 18.15 9.97 37 241518 3286 70683603
Brain injury 18.13 9.97 78 241477 10539 70676350
Sexual abuse 18.12 9.97 11 241544 236 70686653
Dependence 18.12 9.97 30 241525 2270 70684619
Brain malformation 18.06 9.97 7 241548 52 70686837
Decompression sickness 18.06 9.97 7 241548 52 70686837
Allodynia 18.05 9.97 23 241532 1370 70685519
Choreoathetosis 18.04 9.97 24 241531 1492 70685397
Congenital inguinal hernia 17.97 9.97 5 241550 10 70686879
Sleep disorder 17.90 9.97 336 241219 69536 70617353
Compartment syndrome 17.82 9.97 44 241511 4442 70682447
Flat affect 17.80 9.97 27 241528 1896 70684993
Enuresis 17.77 9.97 34 241521 2883 70684006
Haemorrhage intracranial 17.72 9.97 36 241519 24741 70662148
Staphylococcal sepsis 17.68 9.97 12 241543 13415 70673474
Mucormycosis 17.67 9.97 3 241552 8011 70678878
Reduced facial expression 17.63 9.97 30 241525 2322 70684567
Blood loss anaemia 17.59 9.97 14 241541 14427 70672462
Incorrect route of product administration 17.52 9.97 152 241403 26340 70660549
End stage renal disease 17.47 9.97 8 241547 11125 70675764
Clonus 17.47 9.97 54 241501 6214 70680675
Cerebral artery thrombosis 17.43 9.97 20 241535 1068 70685821
Excessive eye blinking 17.36 9.97 23 241532 1424 70685465
Parotid gland enlargement 17.34 9.97 18 241537 858 70686031
Osteoarthritis 17.32 9.97 165 241390 73982 70612907
Labelled drug-drug interaction medication error 17.30 9.97 35 241520 24092 70662797
Dehydration 17.30 9.97 613 240942 225529 70461360
Infantile spasms 17.23 9.97 13 241542 403 70686486
Drug tolerance decreased 17.17 9.97 6 241549 9827 70677062
Neglect of personal appearance 17.16 9.97 9 241546 144 70686745
Oculogyric crisis 17.12 9.97 32 241523 2666 70684223
Injection site pruritus 17.07 9.97 72 241483 39138 70647751
Sebaceous gland infection 17.05 9.97 9 241546 146 70686743
Hyperammonaemic encephalopathy 17.04 9.97 43 241512 4400 70682489
Physical abuse 17.00 9.97 6 241549 33 70686856
Psoriasis 16.77 9.97 235 241320 98198 70588691
Therapeutic response unexpected 16.76 9.97 113 241442 18118 70668771
Formication 16.76 9.97 44 241511 4613 70682276
Cardiac failure chronic 16.71 9.97 7 241548 10262 70676627
Orthostatic tremor 16.70 9.97 6 241549 35 70686854
Ejection fraction abnormal 16.67 9.97 25 241530 1738 70685151
HIV peripheral neuropathy 16.56 9.97 6 241549 36 70686853
Transfusion 16.56 9.97 24 241531 18812 70668077
Aspiration 16.52 9.97 110 241445 17565 70669324
Spasmodic dysphonia 16.50 9.97 10 241545 214 70686675
Anticonvulsant drug level below therapeutic 16.47 9.97 19 241536 1020 70685869
Muscle contracture 16.46 9.97 28 241527 2166 70684723
Dysphagia 16.46 9.97 502 241053 112332 70574557
Osteonecrosis 16.42 9.97 48 241507 29112 70657777
Obsessive thoughts 16.41 9.97 19 241536 1024 70685865
Hyperglycaemia 16.38 9.97 141 241414 64531 70622358
Abulia 16.36 9.97 18 241537 917 70685972
Decreased appetite 16.28 9.97 860 240695 303920 70382969
Disorganised speech 16.26 9.97 25 241530 1776 70685113
Pericardial effusion 16.22 9.97 80 241475 41696 70645193
Petit mal epilepsy 16.20 9.97 48 241507 5396 70681493
Nephrotic syndrome 16.15 9.97 8 241547 10632 70676257
Bladder cancer 16.13 9.97 21 241534 17221 70669668
Dysmorphism 16.08 9.97 14 241541 534 70686355
Cardiac infection 16.06 9.97 11 241544 292 70686597
Forced expiratory volume decreased 15.93 9.97 58 241497 7256 70679633
Learning disorder 15.92 9.97 14 241541 541 70686348
Increased appetite 15.90 9.97 75 241480 10538 70676351
Pneumonia bacterial 15.84 9.97 20 241535 16621 70670268
Epstein-Barr virus infection 15.82 9.97 13 241542 13185 70673704
Rash erythematous 15.81 9.97 107 241448 51611 70635278
Sudden unexplained death in epilepsy 15.76 9.97 15 241540 643 70686246
Myelocyte count increased 15.61 9.97 16 241539 751 70686138
Illness anxiety disorder 15.56 9.97 10 241545 238 70686651
BK virus infection 15.54 9.97 4 241551 7985 70678904
Ulcer 15.54 9.97 41 241514 25713 70661176
Suicidal behaviour 15.49 9.97 33 241522 3023 70683866
Electrocardiogram QRS complex shortened 15.47 9.97 15 241540 658 70686231
Second primary malignancy 15.47 9.97 13 241542 13038 70673851
Intellectual disability 15.46 9.97 19 241536 1091 70685798
Haemoptysis 15.46 9.97 107 241448 51345 70635544
Asphyxia 15.43 9.97 73 241482 10269 70676620
Drug tolerance 15.43 9.97 58 241497 7370 70679519
Band neutrophil count increased 15.40 9.97 15 241540 662 70686227
Sinus pain 15.39 9.97 33 241522 3036 70683853
Lymphadenopathy 15.39 9.97 100 241455 48691 70638198
Myelocyte percentage increased 15.34 9.97 10 241545 244 70686645
Ear congestion 15.27 9.97 28 241527 2299 70684590
Lung disorder 15.24 9.97 157 241398 69327 70617562
Cough 15.22 9.97 930 240625 324447 70362442
Heart rate abnormal 15.18 9.97 48 241507 5591 70681298
Pancreatitis acute 15.14 9.97 91 241464 45133 70641756
Paralysis 15.05 9.97 81 241474 11991 70674898
Medication error 15.04 9.97 275 241280 56637 70630252
Polyarthritis 15.00 9.97 9 241546 10747 70676142
Akinesia 14.95 9.97 33 241522 3098 70683791
Respiratory dyskinesia 14.88 9.97 6 241549 50 70686839
Haemoglobin urine 14.88 9.97 8 241547 135 70686754
Drop attacks 14.86 9.97 18 241537 1018 70685871
Gastrointestinal hypomotility 14.86 9.97 24 241531 1779 70685110
Communication disorder 14.85 9.97 37 241518 3757 70683132
Sleep talking 14.79 9.97 18 241537 1023 70685866
Wrong patient received product 14.79 9.97 41 241514 4439 70682450
Sensorimotor disorder 14.79 9.97 16 241539 800 70686089
Abscess 14.78 9.97 30 241525 20624 70666265
Social avoidant behaviour 14.77 9.97 42 241513 4614 70682275
Dysmetria 14.73 9.97 17 241538 913 70685976
Injection site erythema 14.70 9.97 168 241387 72756 70614133
Troponin increased 14.69 9.97 102 241453 16512 70670377
Product use issue 14.63 9.97 484 241071 179453 70507436
Peroneal nerve palsy 14.62 9.97 47 241508 5523 70681366
Bronchopulmonary aspergillosis allergic 14.60 9.97 25 241530 1944 70684945
Urosepsis 14.54 9.97 38 241517 23911 70662978
Hypersexuality 14.54 9.97 22 241533 1541 70685348
Distractibility 14.53 9.97 15 241540 710 70686179
Renal hypertension 14.51 9.97 9 241546 201 70686688
Mental disability 14.48 9.97 6 241549 54 70686835
Antidepressant drug level above therapeutic 14.46 9.97 14 241541 613 70686276
Staphylococcal bacteraemia 14.46 9.97 10 241545 11072 70675817
Substance use 14.45 9.97 15 241540 715 70686174
Postictal paralysis 14.44 9.97 11 241544 346 70686543
Bradycardia 14.27 9.97 539 241016 124076 70562813
Escherichia sepsis 14.25 9.97 4 241551 7539 70679350
Nail disorder 14.15 9.97 9 241546 10415 70676474
Pseudomonas infection 14.10 9.97 27 241528 18967 70667922
Uveitis 13.97 9.97 18 241537 14827 70672062
Patient uncooperative 13.96 9.97 14 241541 640 70686249
Priapism 13.95 9.97 38 241517 4072 70682817
Death 13.83 9.97 1960 239595 508101 70178788
Prescribed underdose 13.78 9.97 122 241433 21263 70665626
Brain oedema 13.77 9.97 131 241424 23287 70663602
Cystitis haemorrhagic 13.76 9.97 6 241549 8587 70678302
Asthma 13.72 9.97 522 241033 120271 70566618
Piloerection 13.71 9.97 12 241543 461 70686428
Erythema multiforme 13.70 9.97 22 241533 16542 70670347
Hypnopompic hallucination 13.68 9.97 6 241549 63 70686826
Hepatic cancer 13.65 9.97 8 241547 9675 70677214
Gout 13.59 9.97 37 241518 22969 70663920
Postmortem blood drug level increased 13.58 9.97 15 241540 768 70686121
Poverty of speech 13.49 9.97 13 241542 566 70686323
Retinal detachment 13.42 9.97 6 241549 8461 70678428
Heparin-induced thrombocytopenia 13.41 9.97 7 241548 9030 70677859
Wrist fracture 13.41 9.97 71 241484 10445 70676444
Lip and/or oral cavity cancer 13.38 9.97 16 241539 893 70685996
Metastases to central nervous system 13.37 9.97 19 241536 15015 70671874
Pulmonary tuberculosis 13.34 9.97 5 241550 7840 70679049
Terminal insomnia 13.34 9.97 17 241538 1013 70685876
Colitis microscopic 13.33 9.97 7 241548 8998 70677891
Antidepressant drug level increased 13.27 9.97 11 241544 392 70686497
Skin toxicity 13.26 9.97 4 241551 7194 70679695
Blood bicarbonate decreased 13.25 9.97 42 241513 4899 70681990
Cyanosis 13.24 9.97 129 241426 23077 70663812
Locomotive syndrome 13.24 9.97 4 241551 12 70686877
Laryngomalacia 13.24 9.97 4 241551 12 70686877
Organising pneumonia 13.21 9.97 9 241546 10041 70676848
Cushingoid 13.21 9.97 6 241549 8382 70678507
Dermatitis acneiform 13.17 9.97 7 241548 8938 70677951
Therapy interrupted 13.13 9.97 42 241513 24760 70662129
Liver injury 13.00 9.97 84 241471 40951 70645938
Choking 12.97 9.97 73 241482 10987 70675902
Eye movement disorder 12.97 9.97 55 241500 7385 70679504
Cellulitis 12.94 9.97 248 241307 98680 70588209
Haemorrhage 12.93 9.97 204 241351 83611 70603278
Rhabdomyolysis 12.91 9.97 422 241133 95338 70591551
Hyperuricaemia 12.90 9.97 11 241544 10955 70675934
Oral pain 12.88 9.97 53 241502 29013 70657876
Gastrointestinal toxicity 12.86 9.97 3 241552 6402 70680487
Gastric ulcer 12.86 9.97 60 241495 31730 70655159
Pneumothorax 12.83 9.97 45 241510 25801 70661088
Candida infection 12.83 9.97 67 241488 34406 70652483
Tonic clonic movements 12.81 9.97 24 241531 2003 70684886
Glossopharyngeal nerve disorder 12.80 9.97 5 241550 38 70686851
Colon cancer 12.80 9.97 18 241537 14288 70672601
Stoma site irritation 12.79 9.97 9 241546 250 70686639
Anticonvulsant drug level increased 12.78 9.97 27 241528 2459 70684430
Lower gastrointestinal haemorrhage 12.70 9.97 19 241536 14701 70672188
Bulbar palsy 12.69 9.97 9 241546 253 70686636
Oral candidiasis 12.69 9.97 43 241512 24909 70661980
Blood pressure fluctuation 12.67 9.97 134 241421 58878 70628011
Hypoalbuminaemia 12.67 9.97 29 241526 19093 70667796
Fibrous histiocytoma 12.58 9.97 13 241542 616 70686273
Acute hepatic failure 12.55 9.97 50 241505 27622 70659267
Intensive care unit acquired weakness 12.50 9.97 22 241533 1749 70685140
Cataract 12.50 9.97 125 241430 55520 70631369
Haematuria traumatic 12.50 9.97 8 241547 189 70686700
COVID-19 pneumonia 12.49 9.97 36 241519 21933 70664956
Autoimmune hepatitis 12.47 9.97 11 241544 10775 70676114
Barotrauma 12.46 9.97 8 241547 190 70686699
Sinus tachycardia 12.41 9.97 173 241382 33740 70653149
Periorbital swelling 12.38 9.97 25 241530 2205 70684684
Escherichia infection 12.31 9.97 23 241532 16308 70670581
Hepatocellular carcinoma 12.31 9.97 10 241545 10198 70676691
Tooth injury 12.20 9.97 22 241533 1783 70685106
Poor feeding infant 12.10 9.97 7 241548 137 70686752
Left ventricular dysfunction 12.08 9.97 27 241528 17930 70668959
Circulatory collapse 12.08 9.97 71 241484 35403 70651486
Blood iron decreased 12.08 9.97 82 241473 13179 70673710
Affective disorder 12.05 9.97 54 241501 7425 70679464
Helplessness 12.05 9.97 10 241545 357 70686532
Peritonitis 12.04 9.97 47 241508 26112 70660777
Chemical burn of gastrointestinal tract 11.99 9.97 3 241552 3 70686886
Anal spasm 11.99 9.97 3 241552 3 70686886
Duodenal ulcer 11.98 9.97 21 241534 15259 70671630
Peripheral pulse decreased 11.97 9.97 5 241550 46 70686843
Pupillary reflex impaired 11.97 9.97 31 241524 3223 70683666
Product complaint 11.97 9.97 77 241478 12154 70674735
Petechiae 11.97 9.97 30 241525 19142 70667747
Bacterial infection 11.93 9.97 48 241507 26444 70660445
Asterixis 11.90 9.97 26 241529 2423 70684466
Febrile bone marrow aplasia 11.85 9.97 14 241541 11977 70674912
Dizziness 11.80 9.97 1777 239778 462364 70224525
Cerebral atrophy 11.79 9.97 54 241501 7493 70679396
Fear of injection 11.78 9.97 4 241551 6668 70680221
Postmortem blood drug level 11.77 9.97 9 241546 285 70686604
Metastases to lung 11.75 9.97 24 241531 16460 70670429
Neuralgia 11.74 9.97 149 241406 28454 70658435
Pneumonia fungal 11.69 9.97 10 241545 9943 70676946
Live birth 11.68 9.97 18 241537 13761 70673128
Anticonvulsant drug level decreased 11.67 9.97 22 241533 1845 70685044
Deafness neurosensory 11.66 9.97 4 241551 6628 70680261
Blood urea increased 11.66 9.97 100 241455 45809 70641080
Accidental exposure to product by child 11.66 9.97 28 241527 2778 70684111
Enteritis 11.62 9.97 16 241539 12815 70674074
Facial bones fracture 11.61 9.97 38 241517 4506 70682383
Feeling drunk 11.60 9.97 37 241518 4330 70682559
Sensitivity to weather change 11.58 9.97 53 241502 7352 70679537
Somatic symptom disorder 11.56 9.97 23 241532 2007 70684882
Mouth ulceration 11.56 9.97 69 241486 34280 70652609
Cluster headache 11.56 9.97 15 241540 910 70685979
Alcohol abuse 11.55 9.97 41 241514 5066 70681823
Device expulsion 11.54 9.97 38 241517 22208 70664681
Medical device site erosion 11.52 9.97 5 241550 51 70686838
Anhidrosis 11.50 9.97 8 241547 218 70686671
Systemic candida 11.49 9.97 3 241552 5931 70680958
Congenital knee deformity 11.48 9.97 4 241551 21 70686868
Localised infection 11.48 9.97 66 241489 33092 70653797
Antisocial behaviour 11.47 9.97 12 241543 577 70686312
Sternal fracture 11.47 9.97 25 241530 2326 70684563
Binge eating 11.47 9.97 11 241544 476 70686413
Opsoclonus myoclonus 11.47 9.97 8 241547 219 70686670
Acute respiratory failure 11.46 9.97 122 241433 53543 70633346
Impaired self-care 11.45 9.97 25 241530 2329 70684560
Drug level increased 11.37 9.97 181 241374 36288 70650601
Pneumatosis intestinalis 11.35 9.97 3 241552 5884 70681005
Decreased activity 11.33 9.97 54 241501 7620 70679269
Agitated depression 11.27 9.97 9 241546 304 70686585
Erectile dysfunction 11.26 9.97 82 241473 13480 70673409
Brain death 11.23 9.97 41 241514 5137 70681752
Flank pain 11.23 9.97 27 241528 17475 70669414
Dry skin 11.21 9.97 129 241426 55802 70631087
Hypoxic-ischaemic encephalopathy 11.21 9.97 52 241503 7256 70679633
Tenderness 11.17 9.97 36 241519 21174 70665715
Exposure during pregnancy 11.14 9.97 221 241334 87496 70599393
Mucosal erosion 11.10 9.97 23 241532 2066 70684823
Fatigue 11.08 9.97 2563 238992 821756 69865133
Developmental delay 11.00 9.97 16 241539 1082 70685807
Full blood count decreased 10.99 9.97 43 241512 23875 70663014
Drug specific antibody present 10.98 9.97 3 241552 5755 70681134
Urine oxalate increased 10.98 9.97 8 241547 235 70686654
Wrong patient 10.94 9.97 9 241546 317 70686572
Oesophagitis 10.88 9.97 40 241515 22612 70664277
Diabetes mellitus inadequate control 10.86 9.97 40 241515 22605 70664284
Motor dysfunction 10.84 9.97 79 241476 12991 70673898
Polyneuropathy 10.83 9.97 37 241518 21378 70665511
Product quality issue 10.82 9.97 155 241400 30406 70656483
Nodal rhythm 10.80 9.97 28 241527 2913 70683976
Dysgraphia 10.79 9.97 32 241523 3600 70683289
Snoring 10.78 9.97 39 241516 4865 70682024
Inappropriate affect 10.74 9.97 18 241537 1376 70685513
Breath holding 10.74 9.97 5 241550 61 70686828
Abnormal sleep-related event 10.73 9.97 14 241541 854 70686035
Gastric haemorrhage 10.67 9.97 20 241535 14165 70672724
Dissociative identity disorder 10.66 9.97 5 241550 62 70686827
Drug-induced liver injury 10.64 9.97 131 241424 55982 70630907
Narcotic bowel syndrome 10.63 9.97 8 241547 247 70686642
Ammonia abnormal 10.63 9.97 7 241548 174 70686715
Flight of ideas 10.63 9.97 13 241542 743 70686146
Endophthalmitis 10.61 9.97 4 241551 6251 70680638
Sexual dysfunction 10.59 9.97 48 241507 6633 70680256
Central pain syndrome 10.55 9.97 9 241546 334 70686555
Apnoea 10.55 9.97 68 241487 10741 70676148
Homeless 10.53 9.97 6 241549 114 70686775
Rapid eye movements sleep abnormal 10.52 9.97 8 241547 251 70686638
Posterior reversible encephalopathy syndrome 10.50 9.97 45 241510 24357 70662532
Optic nerve operation 10.48 9.97 10 241545 430 70686459
Stoma site pruritus 10.47 9.97 3 241552 7 70686882
Blood phosphorus increased 10.41 9.97 5 241550 6765 70680124
Body height increased 10.39 9.97 6 241549 117 70686772
Niemann-Pick disease 10.39 9.97 6 241549 117 70686772
Pulmonary alveolar haemorrhage 10.36 9.97 12 241543 10357 70676532
Drug screen false positive 10.27 9.97 15 241540 1018 70685871
Monocyte percentage increased 10.27 9.97 22 241533 2023 70684866
Scrotal infection 10.25 9.97 11 241544 545 70686344
Essential tremor 10.25 9.97 18 241537 1429 70685460
Cardiac disorder 10.24 9.97 270 241285 59145 70627744
Nasal oedema 10.23 9.97 17 241538 1290 70685599
Decubitus ulcer 10.22 9.97 83 241472 14108 70672781
Device use error 10.22 9.97 5 241550 6691 70680198
Enterocolitis 10.21 9.97 18 241537 13048 70673841
Blunted affect 10.18 9.97 10 241545 446 70686443
Deformity 10.16 9.97 8 241547 8289 70678600
Gastrointestinal procedural complication 10.15 9.97 7 241548 188 70686701
Tonic convulsion 10.15 9.97 22 241533 2040 70684849
Device related infection 10.13 9.97 66 241489 32119 70654770
Infected bite 10.12 9.97 19 241536 1588 70685301
Blood growth hormone increased 10.09 9.97 12 241543 666 70686223
Toxic skin eruption 10.08 9.97 35 241520 20127 70666762
Embolism 10.05 9.97 18 241537 12970 70673919
Focal dyscognitive seizures 10.05 9.97 30 241525 3387 70683502
Klebsiella infection 10.02 9.97 21 241534 14271 70672618
Neuropsychiatric symptoms 10.02 9.97 15 241540 1041 70685848
Transcription medication error 10.02 9.97 9 241546 358 70686531
Nasal polyps 10.00 9.97 36 241519 4480 70682409
Sinus node dysfunction 10.00 9.97 6 241549 7163 70679726
Feeling cold 9.99 9.97 132 241423 25438 70661451

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Tricuspid valve incompetence 33.98 29.35 12 321 61 89398

Pharmacologic Action:

SourceCodeDescription
ATC N03AE01 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Benzodiazepine derivatives
FDA CS M0002356 Benzodiazepines
CHEBI has role CHEBI:35474 anti-anxiety agents
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:50268 GABA modulators
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D018377 Neurotransmitter Agents
FDA EPC N0000175694 Benzodiazepine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Myoclonic seizure indication 37356005
Atonic seizure indication 42365007
Absence seizure indication 79631006
Lennox-Gastaut syndrome indication 230418006
Panic disorder indication 371631005 DOID:594
Akathisia off-label use 285145004
Manic Bipolar Disorder Adjunct Treatment off-label use
Suicidal thoughts contraindication 6471006
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Hepatic failure contraindication 59927004
Substance abuse contraindication 66214007
Sleep apnea contraindication 73430006 DOID:0050847
Decreased respiratory function contraindication 80954004
Open-angle glaucoma contraindication 84494001 DOID:1067
Kidney disease contraindication 90708001 DOID:557
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Syncope contraindication 271594007
Pregnancy, function contraindication 289908002
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.65 acidic
pKa2 1.65 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 8.07 WOMBAT-PK CHEMBL
GABA-A receptor; anion channel Ion channel Ki 9.07 CHEMBL
GABA-A receptor; anion channel Ion channel IC50 8.77 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 9.07 CHEMBL

External reference:

IDSource
4017791 VUID
N0000146152 NUI
D00280 KEGG_DRUG
202585 RXNORM
4017791 VANDF
C0009011 UMLSCUI
CHEBI:3756 CHEBI
CHEMBL452 ChEMBL_ID
DB01068 DRUGBANK_ID
D002998 MESH_DESCRIPTOR_UI
2802 PUBCHEM_CID
6963 IUPHAR_LIGAND_ID
2765 INN_ID
5PE9FDE8GB UNII
1345 MMSL
377 MMSL
4477 MMSL
d00197 MMSL
001635 NDDF
387383007 SNOMEDCT_US
69708003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Klonopin HUMAN PRESCRIPTION DRUG LABEL 1 0004-0058 TABLET 1 mg ORAL NDA 30 sections
Klonopin HUMAN PRESCRIPTION DRUG LABEL 1 0004-0068 TABLET 0.50 mg ORAL NDA 30 sections
Klonopin HUMAN PRESCRIPTION DRUG LABEL 1 0004-0098 TABLET 2 mg ORAL NDA 30 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-0832 TABLET 0.50 mg ORAL ANDA 20 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-0832 TABLET 0.50 mg ORAL ANDA 20 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3212 TABLET 1 mg ORAL ANDA 20 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3212 TABLET 1 mg ORAL ANDA 20 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3213 TABLET 2 mg ORAL ANDA 20 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3213 TABLET 2 mg ORAL ANDA 20 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9290 TABLET, ORALLY DISINTEGRATING 0.13 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9290 TABLET, ORALLY DISINTEGRATING 0.13 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9291 TABLET, ORALLY DISINTEGRATING 0.25 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9291 TABLET, ORALLY DISINTEGRATING 0.25 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9292 TABLET, ORALLY DISINTEGRATING 0.50 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9292 TABLET, ORALLY DISINTEGRATING 0.50 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9293 TABLET, ORALLY DISINTEGRATING 1 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9293 TABLET, ORALLY DISINTEGRATING 1 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9293 TABLET, ORALLY DISINTEGRATING 1 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9294 TABLET, ORALLY DISINTEGRATING 2 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9294 TABLET, ORALLY DISINTEGRATING 2 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-3003 TABLET 0.50 mg ORAL ANDA 24 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-3004 TABLET 1 mg ORAL ANDA 24 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-3005 TABLET 2 mg ORAL ANDA 24 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0094 TABLET, ORALLY DISINTEGRATING 0.13 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0095 TABLET, ORALLY DISINTEGRATING 0.25 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0096 TABLET, ORALLY DISINTEGRATING 0.50 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0097 TABLET, ORALLY DISINTEGRATING 1 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0098 TABLET, ORALLY DISINTEGRATING 2 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8234 TABLET 0.50 mg ORAL ANDA 26 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8235 TABLET 1 mg ORAL ANDA 26 sections