clonazepam ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 703 1622-61-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clonazepam
  • lonazep
  • klonopin
An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
  • Molecular weight: 315.71
  • Formula: C15H10ClN3O3
  • CLOGP: 2.38
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 87.28
  • ALOGS: -4.47
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
8 mg O
8 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.42 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 98 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.90 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.88 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.15 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 38 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
June 4, 1975 FDA ROCHE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2195.81 9.84 2542 180847 129347 50292388
Toxicity to various agents 808.09 9.84 2126 181263 210373 50211362
Suicide attempt 596.45 9.84 832 182557 50900 50370835
Drug abuse 534.48 9.84 854 182535 58992 50362743
Suicidal ideation 448.14 9.84 756 182633 54629 50367106
Contraindicated product administered 432.66 9.84 27 183362 148931 50272804
Respiratory arrest 428.21 9.84 536 182853 29473 50392262
Synovitis 383.41 9.84 15 183374 123850 50297885
Depression 377.64 9.84 1387 182002 164036 50257699
Intentional overdose 377.63 9.84 752 182637 61752 50359983
Seizure 352.88 9.84 1083 182306 116791 50304944
Cardio-respiratory arrest 351.85 9.84 670 182719 53222 50368513
Somnolence 342.42 9.84 1286 182103 153699 50268036
Drug withdrawal syndrome 321.73 9.84 425 182964 24656 50397079
Overdose 320.85 9.84 940 182449 98787 50322948
Systemic lupus erythematosus 319.67 9.84 61 183328 140561 50281174
Anxiety 309.27 9.84 1369 182020 176237 50245498
Sopor 307.71 9.84 370 183019 19509 50402226
Hand deformity 285.46 9.84 20 183369 100179 50321556
Psychotic disorder 283.46 9.84 372 183017 21440 50400295
Drug intolerance 278.67 9.84 231 183158 218873 50202862
Glossodynia 262.91 9.84 50 183339 115519 50306216
Cardiac arrest 247.79 9.84 766 182623 82885 50338850
Rheumatoid arthritis 243.68 9.84 225 183164 202325 50219410
Infusion related reaction 238.39 9.84 161 183228 169396 50252339
Joint swelling 234.75 9.84 328 183061 244958 50176777
Treatment failure 227.50 9.84 107 183282 137530 50284205
Tremor 226.40 9.84 920 182469 113983 50307752
Irritability 220.55 9.84 381 183008 28045 50393690
Arthropathy 217.89 9.84 153 183236 157753 50263982
Pericarditis 209.57 9.84 21 183368 78668 50343067
Schizophrenia 193.47 9.84 182 183207 7215 50414520
Drug dependence 191.58 9.84 293 183096 19466 50402269
Stubbornness 184.77 9.84 60 183329 225 50421510
Swelling 182.89 9.84 278 183111 200594 50221141
Agitation 179.07 9.84 511 182878 52873 50368862
Rash 178.81 9.84 897 182492 436574 49985161
Intentional self-injury 170.49 9.84 303 183086 22809 50398926
Alopecia 168.87 9.84 401 182988 244646 50177089
Acute kidney injury 167.88 9.84 360 183029 227698 50194037
Poisoning 167.74 9.84 216 183173 12213 50409522
Panic attack 165.67 9.84 271 183118 19071 50402664
Wound 163.19 9.84 90 183299 105704 50316031
Insomnia 162.06 9.84 1137 182252 173728 50248007
Rheumatoid factor positive 154.34 9.84 6 183383 49853 50371882
Hypersensitivity 153.93 9.84 345 183044 214816 50206919
Abdominal discomfort 152.57 9.84 388 183001 231253 50190482
Helicobacter infection 147.28 9.84 8 183381 49694 50372041
Drug hypersensitivity 145.64 9.84 447 182942 250563 50171172
Withdrawal syndrome 144.67 9.84 242 183147 17348 50404387
Neuroleptic malignant syndrome 143.31 9.84 189 183200 10941 50410794
Abnormal behaviour 140.24 9.84 254 183135 19404 50402331
Infection 136.61 9.84 262 183127 172692 50249043
Intentional product misuse 135.56 9.84 425 182964 46309 50375426
Anger 134.57 9.84 185 183204 11148 50410587
Febrile neutropenia 134.17 9.84 95 183294 97572 50324163
Dyskinesia 131.06 9.84 303 183086 27558 50394177
Unresponsive to stimuli 130.07 9.84 320 183069 30289 50391446
Maternal exposure during pregnancy 129.74 9.84 238 183151 159540 50262195
Mental disorder 129.61 9.84 262 183127 21729 50400006
Disturbance in attention 129.33 9.84 323 183066 30863 50390872
Mania 127.82 9.84 177 183212 10739 50410996
Anaemia 120.68 9.84 488 182901 251968 50169767
Thinking abnormal 119.40 9.84 160 183229 9407 50412328
Speech disorder 117.95 9.84 339 183050 35209 50386526
Aggression 117.87 9.84 246 183143 20870 50400865
Mood altered 114.89 9.84 183 183206 12590 50409145
Dystonia 113.01 9.84 175 183214 11751 50409984
Arthralgia 112.73 9.84 1032 182357 437670 49984065
Nightmare 111.14 9.84 205 183184 15881 50405854
Crying 110.65 9.84 235 183154 20181 50401554
Tardive dyskinesia 110.20 9.84 134 183255 7145 50414590
Ataxia 109.83 9.84 187 183202 13599 50408136
Discomfort 109.55 9.84 139 183250 108241 50313494
Stomatitis 108.79 9.84 124 183265 101220 50320515
Hyperhidrosis 108.50 9.84 623 182766 88803 50332932
Muscle injury 106.84 9.84 7 183382 37104 50384631
General physical health deterioration 106.25 9.84 223 183166 142211 50279524
Restless legs syndrome 105.35 9.84 199 183190 15698 50406037
Therapeutic product effect decreased 104.02 9.84 210 183179 135840 50285895
Lower respiratory tract infection 102.71 9.84 116 183273 95085 50326650
Amnesia 102.68 9.84 362 183027 41898 50379837
Serotonin syndrome 102.51 9.84 256 183133 24457 50397278
Memory impairment 102.31 9.84 562 182827 78798 50342937
Feeling abnormal 101.90 9.84 791 182598 124701 50297034
Folliculitis 100.53 9.84 12 183377 39213 50382522
Neutropenia 99.54 9.84 245 183144 147720 50274015
Depressed level of consciousness 99.06 9.84 412 182977 51541 50370194
Paranoia 96.87 9.84 151 183238 10197 50411538
Thrombocytopenia 96.81 9.84 198 183191 127475 50294260
Drooling 93.78 9.84 86 183303 3298 50418437
Hallucination 93.70 9.84 376 183013 46281 50375454
Drug interaction 92.96 9.84 1119 182270 198502 50223233
Peripheral swelling 90.43 9.84 411 182978 205525 50216210
Atrial fibrillation 87.59 9.84 146 183243 101599 50320136
Sedation 87.50 9.84 277 183112 30333 50391402
Feeling of despair 86.52 9.84 66 183323 1952 50419783
Gastric pH decreased 86.41 9.84 44 183345 618 50421117
Impaired healing 84.42 9.84 77 183312 69709 50352026
Hepatic enzyme increased 84.39 9.84 238 183151 137142 50284593
Diarrhoea 83.56 9.84 1567 181822 586909 49834826
Nervousness 82.52 9.84 254 183135 27397 50394338
Muscle rigidity 81.85 9.84 136 183253 9693 50412042
Dissociation 81.22 9.84 67 183322 2224 50419511
Balance disorder 81.21 9.84 485 182904 70105 50351630
Drug withdrawal convulsions 80.46 9.84 54 183335 1299 50420436
Multiple sclerosis 78.48 9.84 206 183183 20287 50401448
Sepsis 78.20 9.84 235 183154 132690 50289045
Cogwheel rigidity 78.14 9.84 59 183330 1718 50420017
Sensitisation 77.37 9.84 56 183333 1526 50420209
Mood swings 75.56 9.84 174 183215 15780 50405955
Mydriasis 75.39 9.84 137 183252 10490 50411245
Off label use 74.69 9.84 1240 182149 473186 49948549
Restlessness 73.97 9.84 230 183159 24943 50396792
Dysarthria 73.17 9.84 299 183090 37104 50384631
Bradyphrenia 72.39 9.84 100 183289 6052 50415683
Malignant neoplasm progression 72.39 9.84 84 183305 68040 50353695
Polycystic ovaries 70.54 9.84 64 183325 2420 50419315
Multiple sclerosis relapse 69.95 9.84 325 183064 42639 50379096
Product substitution issue 68.45 9.84 155 183234 13902 50407833
Disease progression 68.23 9.84 154 183235 95712 50326023
Derealisation 67.67 9.84 44 183345 1002 50420733
Bipolar disorder 66.62 9.84 101 183288 6656 50415079
Drug ineffective 65.53 9.84 2372 181017 816961 49604774
Sleep disorder due to general medical condition, insomnia type 64.64 9.84 17 183372 31430 50390305
Ejection fraction 64.51 9.84 45 183344 1155 50420580
Hypersomnia 63.89 9.84 159 183230 15155 50406580
Hallucination, auditory 63.43 9.84 128 183261 10600 50411135
Pancytopenia 63.10 9.84 131 183258 83899 50337836
Dyspnoea 62.78 9.84 1509 181880 546099 49875636
Pleural effusion 62.00 9.84 126 183263 81328 50340407
Loss of consciousness 61.90 9.84 614 182775 103739 50317996
Gastrointestinal disorder 60.71 9.84 160 183229 94296 50327439
Vision blurred 60.65 9.84 490 182899 78157 50343578
Mucosal inflammation 60.64 9.84 35 183354 40107 50381628
Emotional disorder 60.42 9.84 133 183256 11703 50410032
Respiratory depression 59.11 9.84 133 183256 11877 50409858
Cardiac failure 57.55 9.84 118 183271 75922 50345813
Interstitial lung disease 57.11 9.84 65 183324 53111 50368624
Drug screen negative 57.00 9.84 25 183364 245 50421490
Renal impairment 56.77 9.84 118 183271 75543 50346192
Nasopharyngitis 56.51 9.84 438 182951 192489 50229246
Lactic acidosis 56.50 9.84 25 183364 33330 50388405
Akathisia 54.51 9.84 103 183286 8126 50413609
Gastrointestinal haemorrhage 54.46 9.84 115 183274 73206 50348529
Disorientation 53.11 9.84 262 183127 35222 50386513
Delusion 53.09 9.84 118 183271 10451 50411284
H1N1 influenza 53.09 9.84 45 183344 1552 50420183
Myocardial stunning 51.52 9.84 20 183369 139 50421596
Exposure via ingestion 51.48 9.84 57 183332 2746 50418989
Jaundice cholestatic 51.25 9.84 77 183312 5034 50416701
Depersonalisation/derealisation disorder 50.96 9.84 39 183350 1159 50420576
Therapeutic response unexpected 50.12 9.84 149 183240 15766 50405969
Irritable bowel syndrome 49.88 9.84 68 183321 51373 50370362
Head injury 49.36 9.84 195 183194 23825 50397910
Rheumatic fever 49.09 9.84 3 183386 16864 50404871
Incontinence 48.50 9.84 110 183279 9875 50411860
Granulocytopenia 48.50 9.84 76 183313 5155 50416580
Gait disturbance 48.33 9.84 788 182601 149217 50272518
Bone marrow failure 47.92 9.84 20 183369 27604 50394131
Lethargy 47.79 9.84 325 183064 49107 50372628
Bradykinesia 47.76 9.84 65 183324 3878 50417857
Mental status changes 46.80 9.84 257 183132 36015 50385720
Major depression 46.63 9.84 87 183302 6797 50414938
Migraine 46.62 9.84 447 182942 74833 50346902
Depressed mood 46.57 9.84 245 183144 33778 50387957
Status epilepticus 46.56 9.84 130 183259 13276 50408459
Weight increased 46.53 9.84 1007 182382 200884 50220851
Coma 46.38 9.84 359 183030 56520 50365215
Abnormal dreams 46.33 9.84 104 183285 9273 50412462
Personality disorder 46.03 9.84 67 183322 4257 50417478
Feeling of body temperature change 45.52 9.84 67 183322 4300 50417435
Herpes zoster 45.41 9.84 120 183269 70666 50351069
Myoglobin urine present 45.39 9.84 24 183365 366 50421369
On and off phenomenon 45.33 9.84 39 183350 1373 50420362
Hip arthroplasty 45.30 9.84 27 183362 30402 50391333
Epilepsy 45.05 9.84 176 183213 21391 50400344
Hyperprolactinaemia 44.65 9.84 58 183331 3307 50418428
Multiple-drug resistance 43.78 9.84 57 183332 3257 50418478
Dizziness 43.61 9.84 1599 181790 344770 50076965
Knee arthroplasty 42.81 9.84 40 183349 35806 50385929
Substance abuse 42.59 9.84 63 183326 4061 50417674
Electrocardiogram QT prolonged 42.59 9.84 328 183061 51558 50370177
Myocardial depression 42.17 9.84 24 183365 426 50421309
Decorticate posture 42.07 9.84 21 183368 282 50421453
Blood creatinine increased 41.71 9.84 139 183250 76021 50345714
Middle insomnia 41.38 9.84 103 183286 9818 50411917
Parkinsonism 41.36 9.84 96 183293 8751 50412984
Cardiac failure congestive 40.93 9.84 162 183227 84220 50337515
Sluggishness 40.75 9.84 64 183325 4349 50417386
Product use issue 40.70 9.84 346 183043 149129 50272606
Stress 40.30 9.84 333 183056 53460 50368275
Platelet count decreased 40.11 9.84 208 183181 100518 50321217
Pleurothotonus 39.88 9.84 35 183354 1266 50420469
Dysphoria 39.68 9.84 66 183323 4708 50417027
Palmar-plantar erythrodysaesthesia syndrome 39.20 9.84 12 183377 20086 50401649
Muscle spasms 39.12 9.84 656 182733 124897 50296838
Menstrual disorder 38.46 9.84 62 183327 4308 50417427
Melaena 38.38 9.84 25 183364 26839 50394896
Hypoaesthesia oral 38.21 9.84 105 183284 10623 50411112
Breast hyperplasia 38.07 9.84 19 183370 255 50421480
Atonic seizures 37.78 9.84 25 183364 587 50421148
Drug use disorder 37.76 9.84 51 183338 3021 50418714
Myelosuppression 37.61 9.84 3 183386 13514 50408221
Impaired driving ability 37.35 9.84 58 183331 3903 50417832
C-reactive protein increased 37.31 9.84 120 183269 66354 50355381
Hypercalcaemia 37.26 9.84 19 183370 23333 50398402
Neutrophil count decreased 36.92 9.84 69 183320 45957 50375778
Dopamine dysregulation syndrome 36.20 9.84 16 183373 160 50421575
Movement disorder 36.11 9.84 143 183246 17489 50404246
Hallucinations, mixed 35.82 9.84 58 183331 4045 50417690
Osteonecrosis of jaw 35.75 9.84 39 183350 32487 50389248
Psychomotor hyperactivity 35.10 9.84 93 183296 9208 50412527
Skin ulcer 34.94 9.84 46 183343 35272 50386463
Fall 34.87 9.84 1515 181874 333417 50088318
Blister 34.79 9.84 175 183214 85243 50336492
Urinary retention 34.75 9.84 187 183202 26003 50395732
Rhinitis allergic 34.62 9.84 79 183310 7121 50414614
Persecutory delusion 34.61 9.84 43 183346 2344 50419391
Galactorrhoea 34.39 9.84 54 183335 3669 50418066
Broncholithiasis 34.20 9.84 15 183374 147 50421588
Sleep apnoea syndrome 34.14 9.84 174 183215 23694 50398041
Pneumocystis jirovecii pneumonia 34.06 9.84 6 183383 14657 50407078
Hostility 34.05 9.84 37 183352 1745 50419990
Product complaint 33.90 9.84 105 183284 11361 50410374
Drug screen positive 33.75 9.84 51 183338 3351 50418384
Hyperkalaemia 33.59 9.84 78 183311 48011 50373724
Hypokinesia 33.49 9.84 109 183280 12108 50409627
Incoherent 33.19 9.84 57 183332 4173 50417562
Hypomania 33.13 9.84 59 183330 4446 50417289
Aphasia 32.89 9.84 196 183193 28298 50393437
Therapeutic product ineffective 32.73 9.84 31 183358 1239 50420496
Sleep-related eating disorder 32.67 9.84 25 183364 743 50420992
Stoma site discharge 32.63 9.84 31 183358 1244 50420491
Ill-defined disorder 32.56 9.84 96 183293 54558 50367177
Parosmia 32.50 9.84 58 183331 4378 50417357
Nystagmus 32.46 9.84 66 183323 5495 50416240
Fear 32.25 9.84 121 183268 14428 50407307
Oromandibular dystonia 32.18 9.84 20 183369 420 50421315
Adjustment disorder with mixed anxiety and depressed mood 32.12 9.84 12 183377 74 50421661
Pain 32.03 9.84 1744 181645 577159 49844576
Heart rate increased 32.02 9.84 424 182965 76826 50344909
Rubber sensitivity 31.87 9.84 36 183353 1773 50419962
Coma blister 31.58 9.84 14 183375 141 50421594
Libido increased 31.39 9.84 30 183359 1213 50420522
Electroencephalogram abnormal 31.28 9.84 50 183339 3449 50418286
Miosis 31.19 9.84 70 183319 6240 50415495
Panic disorder 31.03 9.84 40 183349 2263 50419472
Nephrectomy 30.82 9.84 25 183364 810 50420925
Muscle disorder 30.76 9.84 56 183333 4294 50417441
Haemoglobin decreased 30.50 9.84 304 183085 126912 50294823
Toxic encephalopathy 30.48 9.84 64 183325 5451 50416284
Emotional distress 30.46 9.84 193 183196 28470 50393265
Generalised tonic-clonic seizure 30.39 9.84 181 183208 26129 50395606
Catatonia 30.18 9.84 51 183338 3685 50418050
Septic shock 30.18 9.84 106 183283 57069 50364666
Feeling jittery 30.08 9.84 99 183290 11061 50410674
Autonomic nervous system imbalance 29.93 9.84 40 183349 2345 50419390
Renal failure 29.84 9.84 245 183144 106388 50315347
Tension 29.69 9.84 43 183346 2719 50419016
Pulmonary fibrosis 29.50 9.84 27 183362 24410 50397325
Road traffic accident 29.07 9.84 169 183220 24183 50397552
Leukopenia 28.86 9.84 136 183253 67392 50354343
Hereditary angioedema 28.74 9.84 62 183327 5380 50416355
Lymph node calcification 28.70 9.84 15 183374 223 50421512
Anaphylactic reaction 28.68 9.84 100 183289 53955 50367780
Developmental glaucoma 28.03 9.84 10 183379 53 50421682
Bruxism 27.95 9.84 44 183345 2996 50418739
Muscle twitching 27.56 9.84 120 183269 15311 50406424
Mobility decreased 27.56 9.84 173 183216 79775 50341960
Angioedema 27.22 9.84 60 183329 37616 50384119
Tinnitus 27.21 9.84 185 183204 27947 50393788
Pneumonia aspiration 27.13 9.84 199 183190 30805 50390930
Anticonvulsant drug level above therapeutic 27.02 9.84 19 183370 494 50421241
Plasma cell myeloma 26.89 9.84 45 183344 31277 50390458
Right ventricular failure 26.78 9.84 12 183377 15881 50405854
Cytomegalovirus infection 26.65 9.84 16 183373 17946 50403789
Panic reaction 26.58 9.84 47 183342 3522 50418213
Urinary bladder rupture 26.55 9.84 12 183377 127 50421608
Urticaria 26.51 9.84 321 183068 129240 50292495
Hypocalcaemia 26.45 9.84 35 183354 26781 50394954
Affect lability 26.23 9.84 82 183307 8916 50412819
Obsessive-compulsive disorder 26.20 9.84 45 183344 3295 50418440
Extrapyramidal disorder 26.18 9.84 98 183291 11672 50410063
Apathy 26.02 9.84 73 183316 7475 50414260
Head titubation 25.85 9.84 21 183368 682 50421053
Mutism 25.22 9.84 28 183361 1353 50420382
Rash pruritic 25.06 9.84 89 183300 47757 50373978
Neutropenic sepsis 24.93 9.84 10 183379 14137 50407598
Influenza like illness 24.91 9.84 318 183071 57141 50364594
Formication 24.60 9.84 46 183343 3600 50418135
Paralysis 24.38 9.84 78 183311 8586 50413149
Proteinuria 24.32 9.84 15 183374 16582 50405153
Device expulsion 24.20 9.84 42 183347 28780 50392955
Upper gastrointestinal haemorrhage 24.19 9.84 14 183375 16021 50405714
Psychomotor retardation 24.16 9.84 44 183345 3374 50418361
Coordination abnormal 23.99 9.84 94 183295 11440 50410295
Fibromyalgia 23.96 9.84 259 183130 44719 50377016
Sensory loss 23.94 9.84 72 183317 7666 50414069
Aspiration 23.92 9.84 81 183308 9183 50412552
Post-traumatic neck syndrome 23.92 9.84 32 183357 1878 50419857
Anorgasmia 23.46 9.84 18 183371 537 50421198
Urinary tract discomfort 23.28 9.84 13 183376 222 50421513
Sinusitis 23.17 9.84 457 182932 170101 50251634
Neoplasm progression 23.13 9.84 44 183345 29113 50392622
Dysphagia 23.03 9.84 402 182987 77116 50344619
Inflammation 22.94 9.84 117 183272 56795 50364940
Blood creatine phosphokinase increased 22.94 9.84 169 183220 26198 50395537
Neuropathy peripheral 22.86 9.84 232 183157 96525 50325210
Blood sodium decreased 22.85 9.84 143 183246 21004 50400731
Bone erosion 22.76 9.84 7 183382 11680 50410055
Erythema 22.48 9.84 384 183005 146030 50275705
Musculoskeletal pain 22.46 9.84 161 183228 72016 50349719
Tachyphrenia 22.32 9.84 25 183364 1220 50420515
Oropharyngeal oedema 22.25 9.84 13 183376 243 50421492
Transplant rejection 22.17 9.84 4 183385 9605 50412130
Musculoskeletal stiffness 22.05 9.84 330 183059 128151 50293584
Confusional state 22.05 9.84 853 182536 185075 50236660
Hyperbilirubinaemia 22.04 9.84 4 183385 9566 50412169
Pruritus 21.99 9.84 823 182566 282745 50138990
Conversion disorder 21.95 9.84 28 183361 1568 50420167
Logorrhoea 21.87 9.84 34 183355 2290 50419445
Suspected suicide 21.69 9.84 55 183334 5302 50416433
Sleep disorder 21.53 9.84 309 183080 56974 50364761
Dependence 21.35 9.84 30 183359 1845 50419890
Hyperammonaemic encephalopathy 21.31 9.84 31 183358 1968 50419767
Libido decreased 21.31 9.84 34 183355 2342 50419393
Hyponatraemia 21.30 9.84 234 183155 95905 50325830
Band neutrophil percentage increased 21.29 9.84 12 183377 209 50421526
Metastases to liver 21.12 9.84 25 183364 20079 50401656
Exposure during pregnancy 21.06 9.84 310 183079 120705 50301030
Alcohol abuse 21.03 9.84 30 183359 1871 50419864
Freezing phenomenon 21.03 9.84 22 183367 993 50420742
Forced expiratory volume decreased 20.89 9.84 48 183341 4346 50417389
Adverse drug reaction 20.88 9.84 116 183273 55106 50366629
Liver function test increased 20.88 9.84 38 183351 25568 50396167
Pyrexia 20.85 9.84 1146 182243 379057 50042678
Stoma site hypergranulation 20.79 9.84 13 183376 276 50421459
Drug abuser 20.75 9.84 37 183352 2791 50418944
Abulia 20.62 9.84 15 183374 412 50421323
Peroneal nerve palsy 20.60 9.84 47 183342 4236 50417499
Pulmonary arterial hypertension 20.57 9.84 26 183363 20293 50401442
Suicidal behaviour 20.39 9.84 33 183356 2301 50419434
Soft tissue injury 20.35 9.84 26 183363 1458 50420277
Cognitive disorder 20.33 9.84 247 183142 43876 50377859
Weight gain poor 20.30 9.84 19 183370 748 50420987
Intervertebral disc protrusion 20.25 9.84 135 183254 20258 50401477
Dysstasia 20.20 9.84 122 183267 17697 50404038
Hyperreflexia 20.16 9.84 52 183337 5066 50416669
Euphoric mood 20.06 9.84 45 183344 4010 50417725
Carpal tunnel syndrome 20.01 9.84 117 183272 16776 50404959
Creatinine renal clearance decreased 19.97 9.84 9 183380 11872 50409863
Diverticulitis 19.97 9.84 58 183331 33124 50388611
Ascites 19.94 9.84 65 183324 35796 50385939
Stereotypy 19.78 9.84 14 183375 368 50421367
Antidepressant drug level above therapeutic 19.75 9.84 14 183375 369 50421366
Intellectual disability 19.74 9.84 19 183370 775 50420960
Urinary incontinence 19.73 9.84 172 183217 28036 50393699
Dysgraphia 19.65 9.84 35 183354 2638 50419097
Weight abnormal 19.52 9.84 21 183368 979 50420756
Tongue discolouration 19.52 9.84 36 183353 2788 50418947
Antipsychotic drug level increased 19.47 9.84 38 183351 3071 50418664
Attention deficit hyperactivity disorder 19.41 9.84 33 183356 2396 50419339
Food craving 19.40 9.84 25 183364 1414 50420321
Screaming 19.38 9.84 37 183352 2941 50418794
Anaphylactic shock 19.18 9.84 27 183362 20128 50401607
Impulsive behaviour 19.14 9.84 25 183364 1433 50420302
Concussion 19.09 9.84 66 183323 7562 50414173
Acute myeloid leukaemia 18.98 9.84 16 183373 15058 50406677
Pneumonitis 18.94 9.84 50 183339 29460 50392275
Hypervolaemia 18.92 9.84 40 183349 25459 50396276
Hypertension 18.90 9.84 602 182787 210601 50211134
Altered state of consciousness 18.81 9.84 140 183249 21770 50399965
Psoriatic arthropathy 18.78 9.84 97 183292 46935 50374800
Blood test abnormal 18.69 9.84 86 183303 11233 50410502
Colitis 18.66 9.84 74 183315 38455 50383280
Cerebellar atrophy 18.58 9.84 17 183372 650 50421085
Seizure cluster 18.57 9.84 11 183378 211 50421524
Delirium 18.56 9.84 216 183173 37976 50383759
Macular degeneration 18.46 9.84 15 183374 14373 50407362
Bipolar I disorder 18.35 9.84 25 183364 1493 50420242
Somnambulism 18.34 9.84 49 183340 4875 50416860
Decreased interest 18.18 9.84 36 183353 2940 50418795
Initial insomnia 18.15 9.84 50 183339 5065 50416670
Anticonvulsant drug level below therapeutic 18.13 9.84 16 183373 583 50421152
Cholelithiasis 18.12 9.84 214 183175 37759 50383976
Myocardial infarction 18.04 9.84 221 183168 88806 50332929
Psychotic disorder due to a general medical condition 18.04 9.84 11 183378 223 50421512
Hypokalaemia 18.00 9.84 218 183171 87774 50333961
Blood triglycerides increased 17.98 9.84 85 183304 11227 50410508
White blood cell count decreased 17.96 9.84 306 183083 116416 50305319
Epistaxis 17.86 9.84 147 183242 63807 50357928
Alveolar osteitis 17.81 9.84 14 183375 433 50421302
Tic 17.77 9.84 22 183367 1195 50420540
Stoma site pain 17.71 9.84 18 183371 785 50420950
Live birth 17.67 9.84 20 183369 16388 50405347
Jaundice 17.56 9.84 44 183345 26385 50395350
Psychiatric symptom 17.56 9.84 46 183343 4524 50417211
Cytopenia 17.55 9.84 5 183384 8770 50412965
Trismus 17.52 9.84 38 183351 3310 50418425
Tunnel vision 17.49 9.84 17 183372 702 50421033
Mitral valve thickening 17.34 9.84 5 183384 11 50421724
Red blood cell sedimentation rate increased 17.28 9.84 52 183337 29364 50392371
Post-traumatic stress disorder 17.24 9.84 44 183345 4259 50417476
Sexual abuse 16.98 9.84 9 183380 138 50421597
Pulmonary hypertension 16.94 9.84 63 183326 33354 50388381
Social anxiety disorder 16.94 9.84 13 183376 388 50421347
Drug tolerance decreased 16.93 9.84 6 183383 9154 50412581
Hypothermia 16.76 9.84 87 183302 11929 50409806
Choking 16.66 9.84 68 183321 8430 50413305
Hypomagnesaemia 16.62 9.84 37 183352 23119 50398616
Neuropsychiatric symptoms 16.60 9.84 15 183374 564 50421171
Enthesopathy 16.58 9.84 3 183386 7190 50414545
Salivary hypersecretion 16.47 9.84 57 183332 6534 50415201
Change in seizure presentation 16.38 9.84 11 183378 265 50421470
Myelocyte percentage increased 16.34 9.84 10 183379 204 50421531
Peripheral pulse decreased 16.34 9.84 6 183383 35 50421700
Blood parathyroid hormone decreased 16.33 9.84 3 183386 7111 50414624
Injection site pruritus 16.33 9.84 83 183306 40328 50381407
Shock haemorrhagic 16.24 9.84 5 183384 8339 50413396
Stoma site erythema 16.16 9.84 18 183371 873 50420862
Blood growth hormone increased 15.95 9.84 13 183376 424 50421311
Intentional product use issue 15.95 9.84 190 183199 76728 50345007
Hypnopompic hallucination 15.93 9.84 6 183383 38 50421697
Thrombotic microangiopathy 15.84 9.84 6 183383 8785 50412950
Liver function test abnormal 15.77 9.84 95 183294 44244 50377491
Myoclonus 15.73 9.84 98 183291 14372 50407363
Hyperkeratosis 15.72 9.84 47 183342 4988 50416747
Femur fracture 15.68 9.84 76 183313 37388 50384347
Compulsive shopping 15.66 9.84 16 183373 702 50421033
Hypoventilation 15.61 9.84 40 183349 3881 50417854
Anticonvulsant drug level increased 15.54 9.84 22 183367 1362 50420373
Metabolic acidosis 15.54 9.84 80 183309 38745 50382990
Haematochezia 15.50 9.84 83 183306 39799 50381936
Weight decreased 15.48 9.84 964 182425 220281 50201454
Basal cell carcinoma 15.43 9.84 39 183350 23317 50398418
Cytokine release syndrome 15.38 9.84 6 183383 8628 50413107
Coma scale abnormal 15.34 9.84 45 183344 4726 50417009
Monocyte count abnormal 15.32 9.84 9 183380 170 50421565
Visual impairment 15.20 9.84 339 183050 67936 50353799
Upper respiratory tract infection 15.15 9.84 159 183230 65739 50355996
Narcotic bowel syndrome 15.13 9.84 8 183381 122 50421613
Alcohol poisoning 15.11 9.84 25 183364 1775 50419960
Tearfulness 15.08 9.84 38 183351 3649 50418086
Flat affect 15.04 9.84 21 183368 1284 50420451
Pupil fixed 15.02 9.84 23 183366 1529 50420206
Full blood count decreased 15.00 9.84 37 183352 22309 50399426
Increased appetite 14.91 9.84 65 183324 8296 50413439
Self-injurious ideation 14.89 9.84 28 183361 2201 50419534
Diplopia 14.83 9.84 120 183269 19140 50402595
Arthritis 14.79 9.84 223 183166 86498 50335237
Metastases to lung 14.76 9.84 11 183378 11009 50410726
Impulse-control disorder 14.74 9.84 15 183374 655 50421080
Anhedonia 14.73 9.84 71 183318 9453 50412282
Lupus-like syndrome 14.73 9.84 8 183381 9483 50412252
Feelings of worthlessness 14.73 9.84 11 183378 315 50421420
Burning sensation 14.71 9.84 239 183150 45207 50376528
Hyperammonaemia 14.66 9.84 44 183345 4680 50417055
Poor quality sleep 14.65 9.84 107 183282 16539 50405196
Disorganised speech 14.61 9.84 18 183371 973 50420762
Vomiting 14.57 9.84 1455 181934 459303 49962432
Enuresis 14.54 9.84 27 183362 2102 50419633
Drug ineffective for unapproved indication 14.49 9.84 129 183260 21152 50400583
Limb injury 14.44 9.84 124 183265 20126 50401609
Congenital jaw malformation 14.42 9.84 5 183384 24 50421711
Cerebral atrophy 14.41 9.84 43 183346 4558 50417177
Therapy non-responder 14.37 9.84 117 183272 50905 50370830
Disseminated intravascular coagulation 14.36 9.84 25 183364 17110 50404625
Prescribed underdose 14.31 9.84 103 183286 15846 50405889
Flight of ideas 14.26 9.84 11 183378 331 50421404
Right ventricular systolic pressure decreased 14.25 9.84 5 183384 25 50421710
Suspected product quality issue 14.19 9.84 9 183380 196 50421539
Hypoaesthesia 14.18 9.84 580 182809 126677 50295058
Cyanosis 14.18 9.84 99 183290 15085 50406650
Ketosis-prone diabetes mellitus 14.13 9.84 4 183385 8 50421727
Cast application 14.09 9.84 5 183384 26 50421709
Motor dysfunction 14.00 9.84 62 183327 7969 50413766
Electrocardiogram QRS complex shortened 13.96 9.84 12 183377 422 50421313
Infantile spasms 13.92 9.84 9 183380 203 50421532
Bladder pain 13.82 9.84 23 183366 1641 50420094
Blood prolactin increased 13.80 9.84 33 183356 3066 50418669
Pericardial effusion 13.80 9.84 47 183342 25542 50396193
Parkinsonian gait 13.77 9.84 12 183377 430 50421305
Secretion discharge 13.74 9.84 71 183318 9720 50412015
Stupor 13.70 9.84 36 183353 3547 50418188
Drug level above therapeutic 13.60 9.84 38 183351 3882 50417853
International normalised ratio increased 13.55 9.84 96 183293 43056 50378679
Circulatory collapse 13.52 9.84 33 183356 19967 50401768
Homicidal ideation 13.44 9.84 23 183366 1679 50420056
Sensitivity to weather change 13.38 9.84 50 183339 5951 50415784
Feeling drunk 13.25 9.84 36 183353 3617 50418118
Sternal fracture 13.19 9.84 25 183364 1977 50419758
Hallucination, visual 13.14 9.84 104 183285 16478 50405257
Fear of injection 13.13 9.84 3 183386 6100 50415635
Torticollis 13.11 9.84 23 183366 1713 50420022
Drop attacks 13.10 9.84 14 183375 648 50421087
Sebaceous gland infection 13.05 9.84 7 183382 110 50421625
Dysphemia 13.02 9.84 27 183362 2279 50419456
Nephrogenic diabetes insipidus 12.98 9.84 16 183373 865 50420870
Headache 12.98 9.84 2057 181332 504478 49917257
Prescribed overdose 12.94 9.84 94 183295 14506 50407229
Paraesthesia 12.93 9.84 546 182843 119697 50302038
Tonic clonic movements 12.92 9.84 19 183370 1218 50420517
Cushingoid 12.90 9.84 4 183385 6641 50415094
Haemoglobin urine 12.89 9.84 7 183382 113 50421622
Areflexia 12.81 9.84 30 183359 2750 50418985
Cholestasis 12.80 9.84 48 183341 25353 50396382
Aerophagia 12.76 9.84 4 183385 13 50421722
Abdominal pain 12.74 9.84 713 182676 235515 50186220
Mental impairment 12.74 9.84 81 183308 11963 50409772
Abscess 12.72 9.84 20 183369 14252 50407483
Parasomnia 12.70 9.84 11 183378 391 50421344
COVID-19 12.69 9.84 108 183281 46554 50375181
Bronchial wall thickening 12.64 9.84 16 183373 889 50420846
Product quality issue 12.62 9.84 169 183220 30689 50391046
Animal scratch 12.61 9.84 16 183373 891 50420844
Osteoporosis 12.60 9.84 103 183286 44776 50376959
Accidental overdose 12.59 9.84 117 183272 19416 50402319
Distractibility 12.58 9.84 11 183378 396 50421339
Family stress 12.55 9.84 13 183376 580 50421155
Hyperphagia 12.49 9.84 21 183368 1511 50420224
Acute myocardial infarction 12.48 9.84 59 183330 29214 50392521
Hyperacusis 12.47 9.84 23 183366 1781 50419954
Barotrauma 12.43 9.84 8 183381 179 50421556
Fatigue 12.29 9.84 2319 181070 705282 49716453
Klebsiella test positive 12.28 9.84 16 183373 915 50420820
Drug screen false positive 12.27 9.84 15 183374 804 50420931
Affective disorder 12.25 9.84 44 183345 5137 50416598
Heart rate abnormal 12.21 9.84 37 183352 3955 50417780
Clumsiness 12.18 9.84 23 183366 1813 50419922
Fluid retention 12.14 9.84 121 183268 50528 50371207
Oculogyric crisis 12.12 9.84 20 183369 1417 50420318
Focal dyscognitive seizures 12.07 9.84 29 183360 2703 50419032
Vertigo 12.06 9.84 259 183130 51573 50370162
Chronic spontaneous urticaria 12.02 9.84 12 183377 512 50421223
Temporomandibular joint syndrome 11.98 9.84 34 183355 3505 50418230
Illusion 11.91 9.84 16 183373 943 50420792
Amylase increased 11.90 9.84 45 183344 5385 50416350
Band neutrophil count increased 11.89 9.84 10 183379 341 50421394
Bradycardia neonatal 11.88 9.84 15 183374 831 50420904
Ejection fraction abnormal 11.87 9.84 15 183374 832 50420903
Eating disorder 11.86 9.84 96 183293 15313 50406422
Fractured coccyx 11.85 9.84 16 183373 947 50420788
Gaze palsy 11.85 9.84 19 183370 1314 50420421
Pathogen resistance 11.84 9.84 3 183386 5686 50416049
Periorbital swelling 11.82 9.84 23 183366 1854 50419881
Rib fracture 11.82 9.84 114 183275 19107 50402628
Large intestine operation 11.80 9.84 3 183386 3 50421732
Oculocephalogyric reflex absent 11.80 9.84 3 183386 3 50421732
Pre-existing condition improved 11.78 9.84 54 183335 7043 50414692
Haematotoxicity 11.76 9.84 7 183382 7888 50413847
Sensorimotor disorder 11.75 9.84 11 183378 433 50421302
Localised infection 11.68 9.84 50 183339 25435 50396300
Inappropriate schedule of product administration 11.67 9.84 342 183047 71489 50350246
Respiratory rate decreased 11.65 9.84 31 183358 3077 50418658
Onychophagia 11.58 9.84 5 183384 47 50421688
Uveitis 11.58 9.84 10 183379 9300 50412435
Fever neonatal 11.57 9.84 4 183385 19 50421716
Encephalopathy 11.55 9.84 179 183210 33532 50388203
Temperature intolerance 11.51 9.84 56 183333 7483 50414252
Drug detoxification 11.39 9.84 7 183382 144 50421591
Injection site erythema 11.34 9.84 197 183192 74739 50346996
Substance use disorder 11.32 9.84 6 183383 92 50421643
Behaviour disorder 11.32 9.84 26 183363 2354 50419381
Essential tremor 11.27 9.84 15 183374 876 50420859
Oliguria 11.26 9.84 8 183381 8208 50413527
Cerebral haemorrhage 11.25 9.84 55 183334 26997 50394738
Dairy intolerance 11.22 9.84 5 183384 51 50421684
Foetal growth restriction 11.17 9.84 5 183384 6622 50415113
Generalised anxiety disorder 11.10 9.84 22 183367 1798 50419937
Chronic papillomatous dermatitis 11.06 9.84 5 183384 53 50421682
Orthostatic tremor 10.95 9.84 3 183386 5 50421730
Bronchopulmonary aspergillosis 10.93 9.84 7 183382 7585 50414150
Soft tissue haemorrhage 10.93 9.84 8 183381 222 50421513
Accidental exposure to product by child 10.90 9.84 16 183373 1024 50420711
Asthma 10.84 9.84 411 182978 88926 50332809
Binge eating 10.83 9.84 10 183379 387 50421348
Automatism 10.82 9.84 5 183384 56 50421679
Body height increased 10.82 9.84 5 183384 56 50421679
Anuria 10.76 9.84 15 183374 11229 50410506
Urine oxalate increased 10.71 9.84 8 183381 229 50421506
Device difficult to use 10.70 9.84 12 183377 9874 50411861
Transfusion 10.66 9.84 19 183370 12886 50408849
Blepharospasm 10.64 9.84 29 183360 2919 50418816
Acute generalised exanthematous pustulosis 10.64 9.84 10 183379 8928 50412807
Respiratory disorder neonatal 10.63 9.84 15 183374 926 50420809
Cataplexy 10.60 9.84 16 183373 1050 50420685
Pneumonia 10.59 9.84 1205 182184 377196 50044539
Decreased activity 10.57 9.84 42 183347 5145 50416590
Multiple organ dysfunction syndrome 10.56 9.84 124 183265 50213 50371522
Device use error 10.53 9.84 3 183386 5263 50416472
Conjunctivitis allergic 10.52 9.84 13 183376 705 50421030
Hypertonia 10.49 9.84 35 183354 3938 50417797
Sleep terror 10.44 9.84 13 183376 710 50421025
Osteonecrosis 10.43 9.84 44 183345 22473 50399262
Coronary artery disease 10.41 9.84 64 183325 29662 50392073
Schizoaffective disorder 10.38 9.84 24 183365 2182 50419553
Injection site swelling 10.35 9.84 99 183290 41674 50380061
Suspiciousness 10.31 9.84 9 183380 323 50421412
Job dissatisfaction 10.28 9.84 4 183385 28 50421707
Nail disorder 10.28 9.84 12 183377 9696 50412039
Muscle contractions involuntary 10.27 9.84 22 183367 1900 50419835
Pancreatolithiasis 10.25 9.84 8 183381 245 50421490
Myoclonic epilepsy 10.22 9.84 15 183374 960 50420775
Large intestine polyp 10.17 9.84 53 183336 7279 50414456
Stoma site extravasation 10.16 9.84 8 183381 248 50421487
Feeling guilty 10.12 9.84 11 183378 519 50421216
Peritonitis 10.12 9.84 26 183363 15460 50406275
Retinal detachment 10.12 9.84 3 183386 5126 50416609
Eye pain 10.11 9.84 152 183237 28297 50393438
Hepatocellular injury 10.08 9.84 54 183335 25893 50395842
Haematemesis 10.07 9.84 59 183330 27666 50394069
Rash maculo-papular 10.05 9.84 56 183333 26585 50395150
Sleep disorder due to a general medical condition 10.03 9.84 53 183336 7318 50414417
Victim of crime 10.03 9.84 5 183384 67 50421668
Cardiac infection 10.02 9.84 9 183380 336 50421399
Haemangioma congenital 9.97 9.84 10 183379 429 50421306
Aplastic anaemia 9.92 9.84 8 183381 7695 50414040
Agitated depression 9.91 9.84 6 183383 120 50421615
Adverse event 9.89 9.84 106 183283 43657 50378078
Electrocardiogram QRS complex prolonged 9.88 9.84 42 183347 5302 50416433
Metastases to central nervous system 9.88 9.84 16 183373 11266 50410469
Soliloquy 9.86 9.84 7 183382 185 50421550

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 1149.83 10.68 1376 97796 78507 29396848
Completed suicide 798.98 10.68 1228 97944 89018 29386337
Depression 764.03 10.68 1166 98006 83981 29391374
Toxicity to various agents 574.40 10.68 1570 97602 172091 29303264
Somnolence 388.20 10.68 925 98247 93030 29382325
Sopor 302.03 10.68 268 98904 10666 29464689
Drug interaction 297.71 10.68 1379 97793 196006 29279349
Overdose 296.80 10.68 755 98417 79064 29396291
Coma 252.38 10.68 465 98707 38985 29436370
Respiratory arrest 235.56 10.68 357 98815 25476 29449879
Seizure 232.86 10.68 764 98408 92359 29382996
Neuroleptic malignant syndrome 231.18 10.68 278 98894 15870 29459485
Intentional overdose 230.11 10.68 441 98731 38087 29437268
Aggression 219.90 10.68 413 98759 35128 29440227
Suicide attempt 216.82 10.68 401 98771 33709 29441646
Poisoning 214.61 10.68 213 98959 9780 29465575
Agitation 212.49 10.68 506 98666 50798 29424557
Suicidal ideation 199.52 10.68 391 98781 34325 29441030
Anxiety 185.06 10.68 668 98504 84697 29390658
Febrile neutropenia 177.65 10.68 77 99095 112163 29363192
Cardio-respiratory arrest 174.91 10.68 466 98706 50135 29425220
Sedation 169.33 10.68 248 98924 17157 29458198
Psychotic disorder 164.28 10.68 266 98906 20088 29455267
Drug dependence 162.32 10.68 269 98903 20712 29454643
Miosis 161.50 10.68 165 99007 7844 29467511
Intentional product misuse 154.55 10.68 352 98820 34309 29441046
Abnormal behaviour 148.32 10.68 273 98899 22854 29452501
Intentional self-injury 145.75 10.68 194 98978 12267 29463088
Anaemia 145.23 10.68 284 98888 200667 29274688
Drug withdrawal syndrome 141.03 10.68 232 98940 17752 29457603
Acute kidney injury 135.92 10.68 447 98725 264820 29210535
Depressed level of consciousness 130.44 10.68 343 98829 36599 29438756
Status epilepticus 129.25 10.68 170 99002 10624 29464731
Substance abuse 126.39 10.68 134 99038 6653 29468702
Dyspnoea 124.93 10.68 618 98554 326114 29149241
Interstitial lung disease 109.63 10.68 29 99143 57689 29417666
Dyskinesia 106.88 10.68 219 98953 19842 29455513
Loss of personal independence in daily activities 104.24 10.68 250 98922 25190 29450165
Pancytopenia 100.44 10.68 79 99093 83089 29392266
Malignant neoplasm progression 99.98 10.68 62 99110 73797 29401558
Speech disorder 99.50 10.68 234 98938 23282 29452073
Hallucination 96.85 10.68 350 98822 44362 29430993
Altered state of consciousness 96.52 10.68 209 98963 19680 29455675
Insomnia 96.42 10.68 567 98605 88194 29387161
Ataxia 96.05 10.68 157 99015 11946 29463409
Diarrhoea 95.99 10.68 688 98484 332010 29143345
Cardiac arrest 95.73 10.68 551 98621 85040 29390315
Paranoia 94.99 10.68 140 99032 9737 29465618
Panic attack 94.88 10.68 128 99044 8198 29467157
Thrombocytopenia 92.62 10.68 196 98976 134627 29340728
Parkinsonism 92.40 10.68 118 99054 7160 29468195
Bradykinesia 92.21 10.68 83 99089 3364 29471991
Delusion 84.32 10.68 142 99030 11074 29464281
Sepsis 84.03 10.68 225 98947 142457 29332898
Psychiatric decompensation 83.86 10.68 56 99116 1448 29473907
Restlessness 79.56 10.68 207 98965 21938 29453417
Pneumonia aspiration 77.37 10.68 285 98887 36452 29438903
Salivary hypersecretion 77.06 10.68 109 99063 7300 29468055
Granulocytopenia 75.81 10.68 97 99075 5897 29469458
On and off phenomenon 75.73 10.68 58 99114 1870 29473485
Rash 75.23 10.68 354 98818 189465 29285890
Atrial fibrillation 74.70 10.68 151 99021 105495 29369860
Pneumonia 74.51 10.68 701 98471 319471 29155884
Drug withdrawal convulsions 73.98 10.68 47 99125 1114 29474241
Victim of crime 73.00 10.68 32 99140 341 29475014
Serotonin syndrome 72.71 10.68 173 98999 17339 29458016
Renal failure 72.11 10.68 184 98988 118415 29356940
Muscle rigidity 70.55 10.68 119 99053 9292 29466063
Dystonia 70.08 10.68 121 99051 9628 29465727
Mydriasis 70.02 10.68 94 99078 5991 29469364
Disease progression 68.86 10.68 105 99067 81811 29393544
Platelet count decreased 68.69 10.68 156 99016 104516 29370839
Pyrexia 66.32 10.68 631 98541 286991 29188364
Bradyphrenia 66.01 10.68 76 99096 4138 29471217
Psychomotor skills impaired 65.19 10.68 61 99111 2600 29472755
Myocardial infarction 64.09 10.68 175 98997 110121 29365234
Depression suicidal 63.95 10.68 45 99127 1270 29474085
Neutropenia 63.81 10.68 227 98945 131484 29343871
Hyperkalaemia 63.75 10.68 67 99105 61325 29414030
Cardiac failure 63.45 10.68 105 99067 79182 29396173
Tremor 63.31 10.68 443 98729 73095 29402260
Psychomotor hyperactivity 63.09 10.68 105 99067 8108 29467247
Irritability 62.79 10.68 190 98982 21962 29453393
Bradypnoea 61.28 10.68 56 99116 2315 29473040
Thinking abnormal 60.42 10.68 81 99091 5155 29470200
Gastrointestinal haemorrhage 60.29 10.68 109 99063 79424 29395931
Disturbance in attention 60.01 10.68 183 98989 21241 29454114
Hallucination, auditory 59.92 10.68 112 99060 9481 29465874
Renal impairment 59.42 10.68 114 99058 81219 29394136
Anger 59.32 10.68 120 99052 10770 29464585
Stoma site discharge 58.12 10.68 37 99135 880 29474475
Pleural effusion 57.75 10.68 95 99077 71813 29403542
Tearfulness 57.31 10.68 46 99126 1590 29473765
Akathisia 56.97 10.68 90 99082 6652 29468703
Generalised tonic-clonic seizure 56.94 10.68 167 99005 18972 29456383
Epilepsy 56.92 10.68 163 99009 18269 29457086
Confusional state 56.32 10.68 666 98506 127211 29348144
Memory impairment 56.25 10.68 257 98915 36213 29439142
General physical health deterioration 55.50 10.68 169 99003 102688 29372667
Mental impairment 54.96 10.68 105 99067 9036 29466319
Gait disturbance 54.11 10.68 426 98746 72923 29402432
Drug use disorder 54.08 10.68 62 99110 3360 29471995
Cognitive disorder 53.47 10.68 187 98985 23312 29452043
Stomatitis 53.26 10.68 29 99143 37084 29438271
Catatonia 52.91 10.68 70 99102 4398 29470957
Device interaction 52.50 10.68 29 99143 526 29474829
Dysarthria 52.34 10.68 224 98948 30687 29444668
Posture abnormal 52.31 10.68 47 99125 1900 29473455
Joint swelling 51.71 10.68 54 99118 49576 29425779
Drooling 51.61 10.68 57 99115 2964 29472391
Tardive dyskinesia 51.23 10.68 75 99097 5183 29470172
Cardiac failure congestive 51.14 10.68 113 99059 76468 29398887
Disorientation 50.84 10.68 215 98957 29300 29446055
Nervousness 49.45 10.68 114 99058 11192 29464163
Withdrawal syndrome 48.26 10.68 111 99061 10881 29464474
Middle insomnia 47.96 10.68 76 99096 5632 29469723
Prescribed overdose 47.67 10.68 96 99076 8587 29466768
Haemoglobin decreased 46.54 10.68 196 98976 108179 29367176
Behaviour disorder 46.49 10.68 59 99113 3557 29471798
Housebound 45.72 10.68 20 99152 212 29475143
Schizophrenia 45.26 10.68 80 99092 6485 29468870
Depressive symptom 45.25 10.68 41 99131 1676 29473679
Myoclonic epilepsy 44.27 10.68 32 99140 943 29474412
Infusion related reaction 43.23 10.68 50 99122 43836 29431519
Drug abuser 42.33 10.68 58 99114 3769 29471586
Ascites 41.45 10.68 37 99135 36582 29438773
Respiratory depression 41.18 10.68 119 99053 13404 29461951
Acute myocardial infarction 40.77 10.68 62 99110 48376 29426979
Device dislocation 40.43 10.68 62 99110 4465 29470890
Cytomegalovirus infection 39.85 10.68 14 99158 23201 29452154
Oedema peripheral 39.85 10.68 195 98977 103362 29371993
Cerebrovascular accident 39.62 10.68 129 99043 76782 29398573
Urticaria 39.57 10.68 77 99095 54583 29420772
Psychomotor retardation 38.96 10.68 49 99123 2927 29472428
Hyperprolactinaemia 38.83 10.68 33 99139 1237 29474118
Dyspnoea exertional 38.80 10.68 39 99133 36451 29438904
Mental disorder 38.76 10.68 113 99059 12792 29462563
Stoma site erythema 38.75 10.68 25 99147 609 29474746
Abnormal dreams 38.58 10.68 77 99095 6843 29468512
Mucosal inflammation 38.12 10.68 30 99142 31565 29443790
Cerebral haemorrhage 37.72 10.68 30 99142 31396 29443959
Blood creatinine increased 37.72 10.68 152 99020 84950 29390405
Loss of consciousness 37.71 10.68 397 98775 73659 29401696
Myoclonus 37.56 10.68 114 99058 13195 29462160
Unresponsive to stimuli 37.21 10.68 175 98997 24951 29450404
Bone marrow failure 37.17 10.68 23 99149 27426 29447929
Fall 36.99 10.68 815 98357 176363 29298992
Contraindicated product administered 36.98 10.68 8 99164 18258 29457097
Drug hypersensitivity 36.45 10.68 113 99059 68293 29407062
Hallucination, visual 36.35 10.68 122 99050 14893 29460462
Lactic acidosis 36.14 10.68 29 99143 30218 29445137
Dystonic tremor 35.66 10.68 16 99156 181 29475174
Agoraphobia 35.53 10.68 17 99155 225 29475130
Drug ineffective 35.42 10.68 1521 97651 361649 29113706
Nausea 35.41 10.68 721 98451 288534 29186821
Infection 35.34 10.68 135 99037 76616 29398739
Drug diversion 35.31 10.68 26 99146 789 29474566
Angioedema 35.22 10.68 33 99139 31882 29443473
Decreased appetite 35.04 10.68 315 98857 145027 29330328
Toxicologic test abnormal 35.02 10.68 22 99150 511 29474844
Screaming 34.80 10.68 31 99141 1239 29474116
Accidental death 34.53 10.68 39 99133 2079 29473276
Mania 34.26 10.68 84 99088 8579 29466776
Blood creatine phosphokinase increased 33.87 10.68 243 98929 40401 29434954
Melaena 33.52 10.68 33 99139 31143 29444212
Movement disorder 33.04 10.68 92 99080 10145 29465210
Encephalitis toxic 32.78 10.68 17 99155 270 29475085
Pneumocystis jirovecii pneumonia 32.67 10.68 8 99164 16771 29458584
Disinhibition 32.67 10.68 42 99130 2565 29472790
Colitis 32.54 10.68 34 99138 31214 29444141
Hypertonia 32.19 10.68 51 99121 3778 29471577
Product substitution issue 32.18 10.68 85 99087 9087 29466268
Septic shock 32.17 10.68 105 99067 62455 29412900
Psychogenic seizure 31.94 10.68 18 99154 340 29475015
Medication error 31.60 10.68 148 99024 21063 29454292
Electroencephalogram abnormal 31.45 10.68 39 99133 2296 29473059
Arthralgia 31.33 10.68 308 98864 139309 29336046
Drug screen positive 31.09 10.68 50 99122 3751 29471604
Erythema 31.06 10.68 139 99033 75467 29399888
Withdrawal arrhythmia 31.05 10.68 10 99162 40 29475315
Freezing phenomenon 31.03 10.68 29 99143 1234 29474121
Obsessive-compulsive disorder 30.56 10.68 55 99117 4521 29470834
Pruritus 30.50 10.68 248 98924 116601 29358754
Coronary artery disease 30.49 10.68 64 99108 44126 29431229
Feeling of despair 30.35 10.68 25 99147 897 29474458
Postmortem blood drug level increased 30.23 10.68 15 99157 216 29475139
Myelodysplastic syndrome 30.08 10.68 11 99161 17783 29457572
Brain scan abnormal 29.99 10.68 24 99148 826 29474529
Cough 29.95 10.68 276 98896 126451 29348904
Anaphylactic reaction 29.86 10.68 29 99143 27544 29447811
Haematochezia 29.54 10.68 49 99123 36934 29438421
Postmortem blood drug level abnormal 29.53 10.68 16 99156 279 29475076
Poor quality sleep 29.53 10.68 71 99101 7162 29468193
Neuropathy peripheral 29.52 10.68 130 99042 70897 29404458
COVID-19 29.44 10.68 47 99125 35967 29439388
Crying 29.18 10.68 59 99113 5292 29470063
Multiple organ dysfunction syndrome 29.06 10.68 111 99061 63005 29412350
Drug screen negative 29.05 10.68 13 99159 146 29475209
Multiple-drug resistance 28.81 10.68 49 99123 3851 29471504
Haematuria 28.74 10.68 66 99106 44073 29431282
Feeling abnormal 28.71 10.68 294 98878 54151 29421204
Drug intolerance 28.64 10.68 76 99096 48303 29427052
Accidental overdose 28.63 10.68 126 99046 17467 29457888
Cerebral artery thrombosis 28.44 10.68 22 99150 720 29474635
Vessel puncture site erythema 28.21 10.68 6 99166 0 29475355
Illness anxiety disorder 28.15 10.68 13 99159 158 29475197
Bronchopulmonary aspergillosis 28.05 10.68 4 99168 12340 29463015
Proteinuria 28.05 10.68 9 99163 15795 29459560
Bipolar disorder 27.86 10.68 44 99128 3251 29472104
Meconium aspiration syndrome 27.38 10.68 9 99163 39 29475316
Atonic seizures 26.97 10.68 13 99159 175 29475180
Red cell distribution width decreased 26.71 10.68 13 99159 179 29475176
Dysphoria 26.68 10.68 34 99138 2058 29473297
Cerebral infarction 26.66 10.68 26 99146 24649 29450706
Torticollis 26.63 10.68 25 99147 1070 29474285
Anticonvulsant drug level above therapeutic 26.43 10.68 19 99153 555 29474800
Rheumatoid arthritis 26.24 10.68 42 99130 32110 29443245
Plasma cell myeloma 26.24 10.68 53 99119 37062 29438293
Neutropenic sepsis 26.19 10.68 4 99168 11723 29463632
Choreoathetosis 26.18 10.68 24 99148 996 29474359
Purpura fulminans 26.09 10.68 10 99162 73 29475282
Coordination abnormal 26.06 10.68 67 99105 7047 29468308
Hypothermia 25.94 10.68 79 99093 9160 29466195
Drug tolerance 25.91 10.68 34 99138 2119 29473236
Restless legs syndrome 25.81 10.68 66 99106 6918 29468437
Amnesia 25.41 10.68 146 99026 22497 29452858
Failure to suspend medication 25.30 10.68 16 99156 376 29474979
International normalised ratio increased 25.29 10.68 71 99101 44301 29431054
Gastrointestinal hypermotility 25.03 10.68 11 99161 118 29475237
Substance use disorder 24.86 10.68 14 99158 264 29475091
Hyperammonaemia 24.65 10.68 57 99115 5606 29469749
Brain injury 24.57 10.68 56 99116 5456 29469899
Electrocardiogram QRS complex prolonged 24.45 10.68 47 99125 4063 29471292
Talipes 24.25 10.68 30 99142 1762 29473593
Sleep apnoea syndrome 24.20 10.68 120 99052 17479 29457876
Cytokine release syndrome 24.13 10.68 7 99165 13112 29462243
Pulmonary fibrosis 24.12 10.68 11 99161 15571 29459784
Generalised anxiety disorder 24.04 10.68 19 99153 642 29474713
Balance disorder 23.92 10.68 205 98967 35965 29439390
Drug level above therapeutic 23.68 10.68 41 99131 3269 29472086
Acute myeloid leukaemia 23.54 10.68 13 99159 16500 29458855
Myelosuppression 23.48 10.68 6 99166 12221 29463134
Blunted affect 23.36 10.68 14 99158 298 29475057
Delirium 23.34 10.68 218 98954 39179 29436176
Blood creatine phosphokinase 23.33 10.68 9 99163 67 29475288
Multiple sclerosis 23.19 10.68 55 99117 5499 29469856
Basal cell carcinoma 23.13 10.68 14 99158 16896 29458459
Panic disorder 23.05 10.68 24 99148 1166 29474189
Feeling guilty 23.03 10.68 14 99158 306 29475049
Thrombosis 22.99 10.68 71 99101 42974 29432381
Haemorrhage 22.92 10.68 76 99096 44996 29430359
Aspergillus infection 22.76 10.68 4 99168 10577 29464778
Blood bilirubin increased 22.62 10.68 50 99122 33843 29441512
Dysmetria 22.49 10.68 15 99157 387 29474968
Gambling disorder 22.34 10.68 27 99145 1548 29473807
Tubulointerstitial nephritis 22.25 10.68 16 99156 17627 29457728
Hypotonia 22.25 10.68 62 99110 6840 29468515
Cogwheel rigidity 22.18 10.68 24 99148 1219 29474136
Asthenia 22.17 10.68 551 98621 214699 29260656
Arthritis 22.05 10.68 31 99141 24988 29450367
Intensive care unit acquired weakness 21.92 10.68 21 99151 922 29474433
Nightmare 21.90 10.68 86 99086 11331 29464024
Muscle contracture 21.88 10.68 23 99149 1130 29474225
Treatment failure 21.88 10.68 58 99114 36881 29438474
Somnambulism 21.79 10.68 36 99136 2762 29472593
Dehydration 21.78 10.68 263 98909 114485 29360870
Bacteraemia 21.66 10.68 14 99158 16309 29459046
Tachyphrenia 21.62 10.68 23 99149 1146 29474209
Affect lability 21.60 10.68 40 99132 3362 29471993
Pulmonary embolism 21.56 10.68 159 99013 76375 29398980
Exposure via ingestion 21.44 10.68 30 99142 1988 29473367
Vomiting 21.41 10.68 545 98627 211715 29263640
Epistaxis 21.26 10.68 95 99077 51609 29423746
Physical assault 21.25 10.68 22 99150 1062 29474293
Parasomnia 21.20 10.68 14 99158 355 29475000
Tension 21.17 10.68 29 99143 1884 29473471
Depressed mood 21.11 10.68 110 99062 16338 29459017
Injection site exfoliation 21.03 10.68 6 99166 14 29475341
Excessive eye blinking 20.96 10.68 15 99157 435 29474920
Reduced facial expression 20.88 10.68 18 99154 688 29474667
Congenital melanocytic naevus 20.74 10.68 6 99166 15 29475340
Personality disorder 20.60 10.68 22 99150 1101 29474254
Hypomagnesaemia 20.55 10.68 17 99155 17451 29457904
Palmar-plantar erythrodysaesthesia syndrome 20.50 10.68 12 99160 14747 29460608
Ehlers-Danlos syndrome 20.48 10.68 7 99165 35 29475320
Antidepressant drug level increased 20.44 10.68 9 99163 97 29475258
Obsessive-compulsive personality disorder 20.21 10.68 10 99162 143 29475212
Posterior reversible encephalopathy syndrome 20.19 10.68 3 99169 8973 29466382
Partial seizures 20.06 10.68 42 99130 3861 29471494
Stoma site extravasation 19.93 10.68 8 99164 67 29475288
Stereotypy 19.90 10.68 17 99155 642 29474713
Laboratory test abnormal 19.83 10.68 19 99153 18166 29457189
Blood prolactin increased 19.67 10.68 25 99147 1509 29473846
Osteonecrosis of jaw 19.51 10.68 16 99156 16494 29458861
Injection site dryness 19.48 10.68 6 99166 20 29475335
Hyperchloraemia 19.47 10.68 14 99158 409 29474946
Phaeochromocytoma malignant 19.43 10.68 8 99164 72 29475283
Haematemesis 19.32 10.68 33 99139 24593 29450762
Nephropathy toxic 19.31 10.68 6 99166 10750 29464605
Thrombotic microangiopathy 19.30 10.68 3 99169 8678 29466677
Stoma site inflammation 19.18 10.68 14 99158 419 29474936
Language disorder 19.17 10.68 28 99144 1931 29473424
Hepatotoxicity 19.10 10.68 19 99153 17848 29457507
Hypokalaemia 19.02 10.68 95 99077 50108 29425247
Spasmodic dysphonia 18.96 10.68 8 99164 77 29475278
Stoma site infection 18.95 10.68 17 99155 686 29474669
Weight increased 18.69 10.68 361 98811 76306 29399049
Persecutory delusion 18.67 10.68 29 99143 2112 29473243
Angina pectoris 18.65 10.68 41 99131 27809 29447546
Cytopenia 18.62 10.68 5 99167 9854 29465501
Postictal paralysis 18.44 10.68 11 99161 232 29475123
Rapid eye movement sleep behaviour disorder 18.42 10.68 9 99163 125 29475230
Areflexia 18.26 10.68 33 99139 2721 29472634
Peripheral swelling 18.15 10.68 132 99040 63607 29411748
Gaze palsy 17.99 10.68 22 99150 1277 29474078
Hypertension 17.91 10.68 279 98893 116335 29359020
Chills 17.83 10.68 153 99019 71147 29404208
Developmental delay 17.76 10.68 31 99141 2487 29472868
Shock haemorrhagic 17.75 10.68 5 99167 9546 29465809
Autonomic nervous system imbalance 17.75 10.68 30 99142 2346 29473009
Cluster headache 17.74 10.68 14 99158 472 29474883
Physical abuse 17.73 10.68 5 99167 11 29475344
Liver disorder 17.65 10.68 42 99130 27707 29447648
Postmortem blood drug level 17.64 10.68 9 99163 138 29475217
HIV peripheral neuropathy 17.56 10.68 6 99166 30 29475325
Myalgia 17.56 10.68 161 99011 73858 29401497
Apathy 17.54 10.68 53 99119 6118 29469237
Upper gastrointestinal haemorrhage 17.53 10.68 29 99143 21885 29453470
Terminal insomnia 17.53 10.68 13 99159 399 29474956
Electrocardiogram QT shortened 17.52 10.68 9 99163 140 29475215
Drug ineffective for unapproved indication 17.51 10.68 94 99078 14120 29461235
Oedema 17.49 10.68 73 99099 40410 29434945
Hypersomnia 17.48 10.68 77 99095 10677 29464678
Neoplasm progression 17.48 10.68 22 99150 18590 29456765
Postoperative respiratory failure 17.41 10.68 8 99164 96 29475259
Wrong patient received product 17.29 10.68 29 99143 2253 29473102
Extrapyramidal disorder 17.19 10.68 77 99095 10754 29464601
Major depression 17.13 10.68 39 99133 3796 29471559
Post-traumatic stress disorder 17.07 10.68 24 99148 1598 29473757
Hepatic cirrhosis 17.07 10.68 14 99158 14430 29460925
Tumour lysis syndrome 16.98 10.68 13 99159 13871 29461484
Hypomania 16.96 10.68 28 99144 2147 29473208
Antipsychotic drug level increased 16.79 10.68 35 99137 3208 29472147
Prostate cancer 16.75 10.68 38 99134 25489 29449866
Opsoclonus myoclonus 16.72 10.68 7 99165 66 29475289
Developmental regression 16.65 10.68 6 99166 36 29475319
Sedation complication 16.61 10.68 21 99151 1261 29474094
Homicidal ideation 16.43 10.68 30 99142 2494 29472861
Poverty of speech 16.32 10.68 10 99162 222 29475133
Patient uncooperative 16.30 10.68 12 99160 364 29474991
Renal hypertension 16.26 10.68 9 99163 164 29475191
Graft versus host disease 16.19 10.68 6 99166 9622 29465733
Priapism 16.16 10.68 42 99130 4446 29470909
Haemorrhage intracranial 16.09 10.68 15 99157 14527 29460828
Parkinsonian gait 16.06 10.68 13 99159 455 29474900
Change in seizure presentation 16.02 10.68 7 99165 74 29475281
Bruxism 15.99 10.68 23 99149 1564 29473791
Blood bicarbonate decreased 15.98 10.68 28 99144 2254 29473101
Asterixis 15.90 10.68 19 99153 1076 29474279
COVID-19 pneumonia 15.90 10.68 6 99166 9516 29465839
Cholangitis 15.88 10.68 3 99169 7534 29467821
Lymphadenopathy 15.87 10.68 38 99134 25011 29450344
Squamous cell carcinoma of skin 15.81 10.68 6 99166 9480 29465875
Galactorrhoea 15.80 10.68 12 99160 382 29474973
Herpes zoster 15.74 10.68 50 99122 30002 29445353
Depersonalisation/derealisation disorder 15.56 10.68 14 99158 567 29474788
Infantile spasms 15.51 10.68 9 99163 180 29475175
Clonic convulsion 15.48 10.68 14 99158 571 29474784
Dopamine dysregulation syndrome 15.40 10.68 11 99161 318 29475037
Haemophagocytic lymphohistiocytosis 15.37 10.68 8 99164 10496 29464859
Heat stroke 15.27 10.68 17 99155 892 29474463
Feeling jittery 15.19 10.68 36 99136 3597 29471758
Brain oedema 15.18 10.68 81 99091 12139 29463216
Impulsive behaviour 15.14 10.68 25 99147 1918 29473437
Muscle twitching 15.02 10.68 60 99112 7966 29467389
Intelligence test abnormal 14.97 10.68 5 99167 23 29475332
Hyperthermia 14.94 10.68 67 99105 9363 29465992
Psychiatric symptom 14.92 10.68 33 99139 3151 29472204
Allodynia 14.92 10.68 14 99158 599 29474756
Chronic kidney disease 14.91 10.68 67 99105 36349 29439006
Muscle spasticity 14.89 10.68 43 99129 4840 29470515
Petit mal epilepsy 14.83 10.68 30 99142 2692 29472663
Pseudomonas infection 14.82 10.68 9 99163 10843 29464512
Libido increased 14.80 10.68 15 99157 706 29474649
Eye movement disorder 14.78 10.68 36 99136 3660 29471695
Stupor 14.66 10.68 30 99142 2714 29472641
Panic reaction 14.65 10.68 20 99152 1295 29474060
Bradycardia 14.65 10.68 305 98867 65324 29410031
Atrial flutter 14.60 10.68 15 99157 13879 29461476
Pneumothorax 14.59 10.68 19 99153 15823 29459532
Myocarditis 14.56 10.68 74 99098 10882 29464473
Cholestasis 14.54 10.68 36 99136 23426 29451929
Pulmonary hypertension 14.54 10.68 25 99147 18583 29456772
Psychotic behaviour 14.51 10.68 14 99158 620 29474735
Mental status changes 14.50 10.68 180 98992 34747 29440608
Rectal haemorrhage 14.49 10.68 63 99109 34486 29440869
Wrong schedule 14.49 10.68 8 99164 145 29475210
Substance dependence 14.46 10.68 11 99161 351 29475004
Sleep-related eating disorder 14.40 10.68 10 99162 276 29475079
Clostridium difficile infection 14.22 10.68 20 99152 16121 29459234
Anhidrosis 14.22 10.68 7 99165 99 29475256
Accommodation disorder 14.18 10.68 9 99163 213 29475142
Staphylococcal sepsis 14.12 10.68 6 99166 8856 29466499
Adrenal insufficiency 14.12 10.68 10 99162 11104 29464251
Anal spasm 14.10 10.68 3 99169 0 29475355
Eustachian tube disorder 14.10 10.68 3 99169 0 29475355
Suicidal behaviour 14.07 10.68 20 99152 1345 29474010
Stoma site hypergranulation 14.06 10.68 8 99164 154 29475201
Lethargy 14.05 10.68 190 98982 37390 29437965
Hyperphagia 14.03 10.68 19 99153 1221 29474134
Gout 13.88 10.68 22 99150 16889 29458466
Sexual dysfunction 13.86 10.68 47 99125 5767 29469588
Therapy non-responder 13.81 10.68 55 99117 30856 29444499
Syncope 13.77 10.68 191 98981 81180 29394175
Hyperosmolar state 13.76 10.68 11 99161 378 29474977
Frustration tolerance decreased 13.70 10.68 26 99146 2226 29473129
Off label use 13.67 10.68 848 98324 299952 29175403
Urinary tract discomfort 13.62 10.68 7 99165 109 29475246
Drug level decreased 13.59 10.68 49 99123 6198 29469157
Purpura 13.55 10.68 7 99165 9225 29466130
Deep vein thrombosis 13.54 10.68 125 99047 57274 29418081
Embedded device 13.54 10.68 9 99163 231 29475124
Dependence 13.48 10.68 17 99155 1018 29474337
Erectile dysfunction 13.48 10.68 105 99067 17904 29457451
Logorrhoea 13.41 10.68 26 99146 2262 29473093
Myositis 13.40 10.68 9 99163 10274 29465081
Ammonia abnormal 13.36 10.68 6 99166 68 29475287
Rash pruritic 13.33 10.68 35 99137 22328 29453027
Compartment syndrome 13.33 10.68 27 99145 2425 29472930
Treatment noncompliance 13.33 10.68 132 99040 24095 29451260
Monorchidism 13.30 10.68 4 99168 12 29475343
Medical device site dryness 13.30 10.68 4 99168 12 29475343
Locomotive syndrome 13.30 10.68 4 99168 12 29475343
Death 13.27 10.68 978 98194 341106 29134249
Hostility 13.24 10.68 15 99157 802 29474553
Blepharospasm 13.22 10.68 17 99155 1038 29474317
Drug level increased 13.22 10.68 108 99064 18679 29456676
Nystagmus 13.20 10.68 38 99134 4271 29471084
Brain malformation 13.18 10.68 7 99165 117 29475238
Product complaint 13.15 10.68 44 99128 5361 29469994
Staphylococcal infection 13.08 10.68 52 99120 29188 29446167
Niemann-Pick disease 13.06 10.68 4 99168 13 29475342
Tooth injury 13.05 10.68 15 99157 815 29474540
Sleep disorder 12.99 10.68 132 99040 24254 29451101
Fibroma 12.98 10.68 9 99163 248 29475107
Self esteem decreased 12.95 10.68 12 99160 505 29474850
Tuberculosis 12.94 10.68 4 99168 7192 29468163
Road traffic accident 12.93 10.68 93 99079 15468 29459887
Haematuria traumatic 12.92 10.68 8 99164 181 29475174
Labelled drug-drug interaction medication error 12.92 10.68 13 99159 12146 29463209
Stoma site pain 12.91 10.68 12 99160 507 29474848
Nasal septum deviation 12.89 10.68 16 99156 943 29474412
Glossopharyngeal nerve disorder 12.88 10.68 5 99167 38 29475317
Obsessive thoughts 12.87 10.68 13 99159 609 29474746
Confusional arousal 12.84 10.68 4 99168 14 29475341
Communication disorder 12.80 10.68 26 99146 2339 29473016
Ejaculation disorder 12.77 10.68 16 99156 952 29474403
Lennox-Gastaut syndrome 12.76 10.68 5 99167 39 29475316
Cardiac failure chronic 12.75 10.68 3 99169 6464 29468891
Diverticulitis 12.75 10.68 25 99147 17679 29457676
Fatigue 12.73 10.68 903 98269 315918 29159437
Swelling 12.67 10.68 68 99104 35215 29440140
Bipolar I disorder 12.63 10.68 14 99158 731 29474624
Congenital cerebral cyst 12.62 10.68 4 99168 15 29475340
Staphylococcal bacteraemia 12.62 10.68 4 99168 7075 29468280
Dementia with Lewy bodies 12.60 10.68 13 99159 625 29474730
Tachycardia 12.60 10.68 325 98847 72085 29403270
Oesophageal food impaction 12.50 10.68 6 99166 80 29475275
Inflammation 12.48 10.68 37 99135 22691 29452664
Fluid retention 12.48 10.68 39 99133 23521 29451834
Senile dementia 12.44 10.68 5 99167 42 29475313
Mumps 12.43 10.68 6 99166 81 29475274
Inappropriate affect 12.41 10.68 12 99160 533 29474822
Hyperglycaemia 12.35 10.68 66 99106 34221 29441134
Gallbladder polyp 12.35 10.68 10 99162 350 29475005
Blood osmolarity decreased 12.34 10.68 12 99160 537 29474818
Urinary incontinence 12.29 10.68 96 99076 16385 29458970
Weight abnormal 12.28 10.68 11 99161 443 29474912
Abdominal pain 12.20 10.68 353 98819 135004 29340351
Social avoidant behaviour 12.14 10.68 29 99143 2913 29472442
Akinesia 12.14 10.68 23 99149 1967 29473388
Pseudodementia 12.03 10.68 3 99169 3 29475352
Medical device site scab 12.03 10.68 3 99169 3 29475352
Neurosis 12.02 10.68 7 99165 141 29475214
Developmental hip dysplasia 11.97 10.68 9 99163 282 29475073
Jaundice 11.93 10.68 54 99118 29242 29446113
Hypothermia neonatal 11.93 10.68 6 99166 89 29475266
Oropharyngeal pain 11.92 10.68 54 99118 29231 29446124
Arthropathy 11.90 10.68 35 99137 21519 29453836
Rabbit syndrome 11.87 10.68 4 99168 19 29475336
Type 2 diabetes mellitus 11.77 10.68 82 99090 13499 29461856
Multiple sclerosis relapse 11.76 10.68 72 99100 11347 29464008
Lymphopenia 11.69 10.68 17 99155 13516 29461839
Hyperkinesia 11.69 10.68 20 99152 1579 29473776
Diet refusal 11.60 10.68 9 99163 296 29475059
Clonus 11.54 10.68 25 99147 2353 29473002
Personality change 11.50 10.68 38 99134 4600 29470755
Somatic delusion 11.48 10.68 6 99166 97 29475258
Epstein-Barr virus infection 11.37 10.68 4 99168 6625 29468730
Libido decreased 11.37 10.68 36 99136 4262 29471093
Disseminated intravascular coagulation 11.36 10.68 32 99140 19948 29455407
Low birth weight baby 11.31 10.68 4 99168 6604 29468751
Swelling face 11.27 10.68 33 99139 20317 29455038
Bulbar palsy 11.21 10.68 8 99164 231 29475124
Hallucinations, mixed 11.16 10.68 25 99147 2408 29472947
Acute coronary syndrome 11.13 10.68 15 99157 12310 29463045
Feeling drunk 11.11 10.68 20 99152 1644 29473711
Pneumonia bacterial 11.11 10.68 9 99163 9334 29466021
Dissociative identity disorder 11.10 10.68 4 99168 24 29475331
Hypocalcaemia 11.09 10.68 34 99138 20631 29454724
Sleep paralysis 11.09 10.68 7 99165 164 29475191
Hyperhidrosis 11.03 10.68 289 98883 64251 29411104
Suspected suicide 10.94 10.68 34 99138 3986 29471369
Face oedema 10.92 10.68 11 99161 10272 29465083
Intraventricular haemorrhage neonatal 10.89 10.68 8 99164 242 29475113
Ammonia increased 10.88 10.68 34 99138 3997 29471358
Poisoning deliberate 10.85 10.68 43 99129 5688 29469667
Hemiparesis 10.83 10.68 20 99152 14466 29460889
Sinus tachycardia 10.81 10.68 87 99085 14982 29460373
Irregular sleep phase 10.74 10.68 5 99167 62 29475293
Renal injury 10.73 10.68 11 99161 10191 29465164

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3162.30 9.77 3913 222943 220501 64051375
Drug abuse 1559.20 9.77 2116 224740 130258 64141618
Toxicity to various agents 1383.96 9.77 3568 223288 359945 63911931
Respiratory arrest 807.95 9.77 964 225892 52021 64219855
Depression 654.03 9.77 1759 225097 181532 64090344
Suicide attempt 652.25 9.77 1010 225846 69997 64201879
Intentional overdose 586.04 9.77 1098 225758 88846 64183030
Cardio-respiratory arrest 584.54 9.77 1155 225701 97238 64174638
Somnolence 578.48 9.77 1801 225055 201844 64070032
Sopor 570.35 9.77 609 226247 29052 64242824
Overdose 563.71 9.77 1526 225330 158040 64113836
Suicidal ideation 435.40 9.77 814 226042 65728 64206148
Cardiac arrest 432.06 9.77 1357 225499 152707 64119169
Poisoning 411.42 9.77 444 226412 21435 64250441
Psychotic disorder 372.14 9.77 530 226326 34048 64237828
Drug withdrawal syndrome 359.65 9.77 495 226361 30796 64241080
Seizure 355.13 9.77 1341 225515 165551 64106325
Neuroleptic malignant syndrome 343.94 9.77 432 226424 24564 64247312
Anxiety 325.03 9.77 1493 225363 201156 64070720
Intentional self-injury 316.70 9.77 448 226408 28596 64243280
Drug dependence 311.53 9.77 478 226378 32834 64239042
Synovitis 310.58 9.77 8 226848 99082 64172794
Agitation 301.61 9.77 835 226021 87532 64184344
Acute kidney injury 298.19 9.77 717 226139 448523 63823353
Intentional product misuse 288.33 9.77 724 226132 71571 64200305
Febrile neutropenia 283.94 9.77 153 226703 187504 64084372
Aggression 275.87 9.77 544 226312 45688 64226188
Contraindicated product administered 270.89 9.77 31 226825 107798 64164078
Drug interaction 261.25 9.77 2169 224687 359914 63911962
Anaemia 245.92 9.77 611 226245 378069 63893807
Coma 243.77 9.77 770 226086 86845 64185031
Abnormal behaviour 235.86 9.77 424 226432 33198 64238678
Depressed level of consciousness 216.82 9.77 705 226151 80731 64191145
Schizophrenia 208.82 9.77 226 226630 10942 64260934
Tremor 205.69 9.77 1048 225808 147182 64124694
Infusion related reaction 205.61 9.77 166 226690 164301 64107575
Drug intolerance 197.35 9.77 222 226634 187770 64084106
Dyskinesia 191.25 9.77 426 226430 38962 64232914
Panic attack 189.37 9.77 296 226560 20657 64251219
Sedation 187.52 9.77 436 226420 41026 64230850
Speech disorder 186.72 9.77 479 226377 47962 64223914
Insomnia 184.67 9.77 1260 225596 196576 64075300
Joint swelling 182.92 9.77 297 226559 215085 64056791
Stubbornness 181.38 9.77 60 226796 251 64271625
Irritability 180.18 9.77 399 226457 36347 64235529
Ataxia 179.12 9.77 297 226559 21787 64250089
Rash 174.06 9.77 926 225930 457623 63814253
Miosis 169.45 9.77 221 226635 13045 64258831
Rheumatoid arthritis 164.91 9.77 201 226655 164093 64107783
Thrombocytopenia 162.18 9.77 340 226516 223461 64048415
Drug withdrawal convulsions 161.57 9.77 98 226758 2030 64269846
Serotonin syndrome 161.40 9.77 398 226458 38884 64232992
Hand deformity 160.28 9.77 17 226839 62754 64209122
Thinking abnormal 153.05 9.77 196 226660 11360 64260516
Paranoia 150.55 9.77 233 226623 16119 64255757
Sepsis 149.82 9.77 371 226485 229970 64041906
Pancytopenia 149.53 9.77 170 226686 143139 64128737
Drug hypersensitivity 149.31 9.77 390 226466 237425 64034451
Neutropenia 146.63 9.77 398 226458 239226 64032650
Atrial fibrillation 143.29 9.77 238 226618 170851 64101025
Substance abuse 143.05 9.77 170 226686 9122 64262754
Unresponsive to stimuli 142.97 9.77 446 226410 49947 64221929
General physical health deterioration 142.75 9.77 317 226539 204108 64067768
Dystonia 140.16 9.77 244 226612 18621 64253255
Systemic lupus erythematosus 139.93 9.77 49 226807 77563 64194313
Mydriasis 139.32 9.77 217 226639 15095 64256781
Diarrhoea 139.28 9.77 1752 225104 720952 63550924
Interstitial lung disease 138.73 9.77 86 226770 97646 64174230
Dyspnoea 138.20 9.77 1743 225113 716931 63554945
Muscle rigidity 133.74 9.77 229 226627 17244 64254632
Treatment failure 132.60 9.77 129 226727 116687 64155189
Pericarditis 132.22 9.77 29 226827 62487 64209389
Withdrawal syndrome 128.87 9.77 267 226589 23225 64248651
Malignant neoplasm progression 128.87 9.77 124 226732 112747 64159129
Tardive dyskinesia 128.43 9.77 160 226696 9018 64262858
Bradyphrenia 125.30 9.77 160 226696 9246 64262630
Arthropathy 124.56 9.77 145 226711 120822 64151054
Granulocytopenia 124.23 9.77 168 226688 10272 64261604
Mental disorder 122.77 9.77 281 226575 26164 64245712
Stomatitis 122.15 9.77 123 226733 109482 64162394
Hallucination 120.72 9.77 542 226314 72246 64199630
Disturbance in attention 120.67 9.77 368 226488 40706 64231170
Restless legs syndrome 120.22 9.77 216 226640 16900 64254976
Status epilepticus 119.76 9.77 247 226609 21416 64250460
Feeling of despair 116.85 9.77 86 226770 2482 64269394
Disease progression 116.85 9.77 199 226657 141481 64130395
Restlessness 115.53 9.77 355 226501 39430 64232446
Infection 115.38 9.77 304 226552 184576 64087300
Mania 114.99 9.77 206 226650 16080 64255796
Hypersensitivity 114.45 9.77 334 226522 196118 64075758
Drooling 112.57 9.77 115 226741 5204 64266672
Bradykinesia 111.00 9.77 126 226730 6434 64265442
Glossodynia 108.08 9.77 46 226810 64650 64207226
Memory impairment 107.91 9.77 590 226266 85092 64186784
Helicobacter infection 107.25 9.77 7 226849 38355 64233521
Gastrointestinal haemorrhage 107.14 9.77 188 226668 132124 64139752
Pleural effusion 106.92 9.77 175 226681 126384 64145492
Parkinsonism 105.60 9.77 185 226671 14188 64257688
Renal impairment 104.72 9.77 197 226659 134820 64137056
Anger 103.42 9.77 193 226663 15548 64256328
Crying 102.85 9.77 222 226634 19868 64252008
Cardiac failure 102.79 9.77 193 226663 132180 64139696
Platelet count decreased 99.97 9.77 282 226574 167429 64104447
Hyperkalaemia 99.05 9.77 126 226730 101003 64170873
Akathisia 99.03 9.77 159 226697 11351 64260525
Rheumatoid factor positive 98.80 9.77 6 226850 34932 64236944
Generalised tonic-clonic seizure 97.98 9.77 336 226520 39521 64232355
Lactic acidosis 97.38 9.77 47 226809 61363 64210513
Swelling 96.53 9.77 268 226588 159950 64111926
Pneumonia aspiration 95.77 9.77 438 226418 58833 64213043
Alopecia 95.54 9.77 283 226573 165407 64106469
Hallucination, auditory 94.65 9.77 194 226662 16745 64255131
On and off phenomenon 94.07 9.77 75 226781 2444 64269432
Cogwheel rigidity 94.05 9.77 79 226777 2774 64269102
Altered state of consciousness 90.98 9.77 317 226539 37585 64234291
Respiratory depression 90.51 9.77 232 226624 23211 64248665
Dysarthria 89.39 9.77 430 226426 58976 64212900
Arthralgia 88.74 9.77 1062 225794 441198 63830678
Mood altered 86.93 9.77 181 226675 15798 64256078
Renal failure 85.32 9.77 339 226517 181349 64090527
Bone marrow failure 85.19 9.77 31 226825 47921 64223955
Middle insomnia 84.74 9.77 158 226698 12719 64259157
Myocardial infarction 83.97 9.77 300 226556 165521 64106355
Drug use disorder 83.84 9.77 105 226751 5949 64265927
Psychomotor hyperactivity 83.71 9.77 168 226688 14283 64257593
Multiple sclerosis 81.09 9.77 195 226661 18746 64253130
Mucosal inflammation 80.90 9.77 61 226795 62523 64209353
Gastric pH decreased 80.48 9.77 43 226813 692 64271184
Cardiac failure congestive 80.46 9.77 216 226640 130364 64141512
Loss of consciousness 79.57 9.77 835 226021 147530 64124346
Pyrexia 79.53 9.77 1435 225421 557209 63714667
Impaired healing 79.38 9.77 58 226798 60415 64211461
Blood creatinine increased 78.93 9.77 231 226625 135551 64136325
Psychiatric decompensation 78.73 9.77 67 226789 2396 64269480
Disorientation 78.23 9.77 396 226460 55432 64216444
Gait disturbance 77.86 9.77 937 225919 171218 64100658
Maternal exposure during pregnancy 77.83 9.77 136 226720 95748 64176128
Drug abuser 77.69 9.77 99 226757 5709 64266167
Nightmare 77.19 9.77 204 226652 20789 64251087
Victim of crime 76.71 9.77 35 226821 392 64271484
Delusion 75.56 9.77 184 226672 17830 64254046
Sensitisation 74.36 9.77 56 226800 1675 64270201
Feeling abnormal 74.05 9.77 757 226099 132845 64139031
Salivary hypersecretion 74.00 9.77 144 226712 11969 64259907
Hyperprolactinaemia 73.79 9.77 81 226775 3984 64267892
Catatonia 73.56 9.77 111 226745 7509 64264367
Cytomegalovirus infection 73.30 9.77 20 226836 37179 64234697
Wound 72.10 9.77 98 226758 76379 64195497
Balance disorder 72.02 9.77 524 226332 83402 64188474
Lower respiratory tract infection 71.64 9.77 140 226716 94474 64177402
Melaena 70.75 9.77 51 226805 53497 64218379
Derealisation 70.14 9.77 51 226805 1444 64270432
Peripheral swelling 69.69 9.77 440 226416 208713 64063163
Polycystic ovaries 69.66 9.77 59 226797 2096 64269780
Amnesia 69.48 9.77 345 226511 47924 64223952
Hypersomnia 67.88 9.77 187 226669 19530 64252346
Hyperhidrosis 67.42 9.77 704 226152 124216 64147660
Haemoglobin decreased 67.25 9.77 406 226450 194657 64077219
Dissociation 67.20 9.77 67 226789 2944 64268932
Stoma site discharge 66.95 9.77 52 226804 1630 64270246
Exposure via ingestion 66.27 9.77 84 226772 4818 64267058
Off label use 66.11 9.77 1708 225148 631098 63640778
Bipolar disorder 65.99 9.77 99 226757 6662 64265214
Abdominal discomfort 65.77 9.77 374 226482 181948 64089928
Epilepsy 64.31 9.77 261 226595 33270 64238606
Ejection fraction 62.91 9.77 45 226811 1241 64270635
Multiple sclerosis relapse 62.78 9.77 299 226557 40836 64231040
Emotional disorder 61.91 9.77 137 226719 12470 64259406
Septic shock 61.54 9.77 179 226677 105258 64166618
Folliculitis 61.51 9.77 15 226841 30062 64241814
Mood swings 61.46 9.77 167 226689 17301 64254575
Nervousness 60.67 9.77 235 226621 29321 64242555
Angioedema 60.55 9.77 77 226779 61744 64210132
Depersonalisation/derealisation disorder 59.48 9.77 48 226808 1592 64270284
Electroencephalogram abnormal 59.29 9.77 82 226774 5121 64266755
Muscle injury 58.52 9.77 11 226845 26426 64245450
Urticaria 57.09 9.77 295 226561 147022 64124854
Myelosuppression 57.04 9.77 8 226848 23822 64248054
Personality disorder 56.34 9.77 76 226780 4635 64267241
Pneumocystis jirovecii pneumonia 56.08 9.77 14 226842 27620 64244256
Anticonvulsant drug level above therapeutic 54.94 9.77 38 226818 992 64270884
Ascites 54.94 9.77 83 226773 61918 64209958
Movement disorder 54.53 9.77 186 226670 21814 64250062
Haematochezia 53.98 9.77 94 226762 66279 64205597
Feeling of body temperature change 53.56 9.77 75 226781 4739 64267137
Hepatic enzyme increased 53.34 9.77 255 226601 129688 64142188
Confusional state 53.32 9.77 1248 225608 259896 64011980
Herpes zoster 52.63 9.77 126 226730 79061 64192815
Anaphylactic reaction 51.63 9.77 102 226754 68562 64203314
Palmar-plantar erythrodysaesthesia syndrome 50.57 9.77 19 226837 28800 64243076
Drug screen positive 50.46 9.77 80 226776 5649 64266227
Neuropathy peripheral 50.38 9.77 227 226629 117298 64154578
Osteonecrosis of jaw 49.96 9.77 40 226816 39785 64232091
Therapeutic product effect decreased 49.93 9.77 222 226634 115129 64156747
Dopamine dysregulation syndrome 49.59 9.77 27 226829 452 64271424
Acute myocardial infarction 49.52 9.77 107 226749 69611 64202265
Feeling jittery 49.35 9.77 113 226743 10522 64261354
Pneumonia 49.31 9.77 1546 225310 558030 63713846
Transplant rejection 49.16 9.77 3 226853 17398 64254478
Mental status changes 49.13 9.77 376 226480 60786 64211090
Erythema 49.11 9.77 421 226435 186649 64085227
Myocardial stunning 48.85 9.77 20 226836 168 64271708
Neutrophil count decreased 48.06 9.77 127 226729 77069 64194807
Breast hyperplasia 47.91 9.77 18 226838 117 64271759
Tearfulness 47.87 9.77 70 226786 4603 64267273
Depression suicidal 47.87 9.77 51 226805 2424 64269452
Mental impairment 47.59 9.77 146 226710 16197 64255679
Psychomotor skills impaired 47.47 9.77 63 226793 3782 64268094
Behaviour disorder 47.40 9.77 68 226788 4394 64267482
Drug screen negative 47.18 9.77 22 226834 260 64271616
Blood creatine phosphokinase increased 47.04 9.77 360 226496 58198 64213678
Loss of personal independence in daily activities 46.76 9.77 424 226432 72030 64199846
Stoma site erythema 46.50 9.77 37 226819 1202 64270674
Galactorrhoea 46.46 9.77 57 226799 3162 64268714
Menstrual disorder 46.02 9.77 58 226798 3307 64268569
Tension 46.00 9.77 62 226794 3778 64268098
Upper gastrointestinal haemorrhage 45.94 9.77 34 226822 35186 64236690
Proteinuria 45.84 9.77 20 226836 27703 64244173
Abnormal dreams 45.82 9.77 108 226748 10248 64261628
Sleep-related eating disorder 45.68 9.77 29 226827 653 64271223
Colitis 45.12 9.77 86 226770 58588 64213288
Incontinence 45.03 9.77 118 226738 11963 64259913
Sleep disorder due to general medical condition, insomnia type 44.97 9.77 18 226838 26252 64245624
Neutropenic sepsis 44.94 9.77 13 226843 23259 64248617
Housebound 44.81 9.77 25 226831 440 64271436
Decorticate posture 44.73 9.77 22 226834 295 64271581
Pulmonary fibrosis 44.20 9.77 25 226831 29853 64242023
Psychomotor retardation 44.18 9.77 71 226785 5072 64266804
Dysphoria 43.90 9.77 65 226791 4323 64267553
Atonic seizures 43.85 9.77 28 226828 637 64271239
Hallucinations, mixed 43.30 9.77 77 226779 5975 64265901
Multiple-drug resistance 43.06 9.77 80 226776 6422 64265454
Cognitive disorder 42.78 9.77 336 226520 54751 64217125
Hypercalcaemia 42.72 9.77 29 226827 31387 64240489
Red blood cell sedimentation rate abnormal 42.71 9.77 4 226852 16302 64255574
Fall 42.58 9.77 1832 225024 414994 63856882
Hypertension 42.32 9.77 649 226207 258612 64013264
Nasopharyngitis 42.27 9.77 463 226393 195610 64076266
Hypoaesthesia oral 42.03 9.77 112 226744 11468 64260408
Cerebral haemorrhage 41.87 9.77 72 226784 51018 64220858
Myoclonus 41.59 9.77 187 226669 24931 64246945
Cytokine release syndrome 41.41 9.77 11 226845 20818 64251058
Depressed mood 41.06 9.77 266 226590 40746 64231130
Haematuria 40.35 9.77 96 226760 60375 64211501
Myocardial depression 40.35 9.77 24 226832 479 64271397
Autonomic nervous system imbalance 39.61 9.77 60 226796 4072 64267804
Prescribed overdose 39.58 9.77 159 226697 20172 64251704
Screaming 39.29 9.77 55 226801 3474 64268402
H1N1 influenza 39.15 9.77 44 226812 2222 64269654
Hypocalcaemia 38.85 9.77 54 226802 41699 64230177
Bradypnoea 38.67 9.77 67 226789 5092 64266784
Gastrointestinal disorder 38.61 9.77 173 226683 89536 64182340
Depressive symptom 38.53 9.77 62 226794 4434 64267442
Major depression 38.45 9.77 85 226771 7731 64264145
Hostility 38.38 9.77 43 226813 2164 64269712
Multiple organ dysfunction syndrome 38.20 9.77 205 226651 101208 64170668
Myoclonic epilepsy 38.15 9.77 37 226819 1571 64270305
Therapeutic product ineffective 38.15 9.77 36 226820 1477 64270399
Myelodysplastic syndrome 38.12 9.77 25 226831 27554 64244322
Bronchopulmonary aspergillosis 38.09 9.77 10 226846 19075 64252801
Rubber sensitivity 38.08 9.77 34 226822 1298 64270578
Persecutory delusion 37.92 9.77 59 226797 4099 64267777
Discomfort 37.87 9.77 151 226705 80727 64191149
Stereotypy 37.87 9.77 28 226828 814 64271062
Acute myeloid leukaemia 37.81 9.77 25 226831 27438 64244438
Tumour lysis syndrome 37.28 9.77 11 226845 19429 64252447
Head injury 37.27 9.77 220 226636 32622 64239254
Electrocardiogram QRS complex prolonged 37.26 9.77 93 226763 9151 64262725
Shock haemorrhagic 37.14 9.77 7 226849 16784 64255092
Electrocardiogram QT prolonged 37.01 9.77 435 226421 79013 64192863
Oedema peripheral 36.91 9.77 519 226337 209798 64062078
Myoglobin urine present 36.83 9.77 24 226832 566 64271310
Plasma cell myeloma 36.79 9.77 66 226790 46009 64225867
Product substitution issue 36.64 9.77 142 226714 17719 64254157
Libido increased 36.61 9.77 38 226818 1752 64270124
Sluggishness 36.59 9.77 69 226787 5601 64266275
Hypokinesia 36.58 9.77 135 226721 16461 64255415
Toxicologic test abnormal 36.47 9.77 32 226824 1193 64270683
Nystagmus 36.31 9.77 91 226765 8977 64262899
Hypomagnesaemia 36.13 9.77 47 226809 37329 64234547
Substance use disorder 36.10 9.77 20 226836 347 64271529
Rash pruritic 36.07 9.77 94 226762 57310 64214566
Adjustment disorder with mixed anxiety and depressed mood 36.05 9.77 13 226843 74 64271802
Sleep apnoea syndrome 35.92 9.77 203 226653 29629 64242247
C-reactive protein increased 35.67 9.77 192 226664 94717 64177159
Hypothermia 35.29 9.77 151 226705 19705 64252171
Antipsychotic drug level increased 35.21 9.77 64 226792 5051 64266825
Nausea 35.21 9.77 2337 224519 783463 63488413
Neoplasm progression 35.18 9.77 56 226800 40908 64230968
Hyperammonaemia 35.15 9.77 95 226761 9809 64262067
International normalised ratio increased 35.08 9.77 151 226705 79016 64192860
Dystonic tremor 34.93 9.77 16 226840 181 64271695
Coordination abnormal 34.91 9.77 124 226732 14840 64257036
Hypokalaemia 34.88 9.77 268 226588 121635 64150241
Posture abnormal 34.86 9.77 51 226805 3355 64268521
Thrombotic microangiopathy 34.66 9.77 8 226848 16647 64255229
Cerebrovascular accident 34.60 9.77 313 226543 137270 64134606
Delirium 34.54 9.77 384 226472 68810 64203066
Disinhibition 34.46 9.77 41 226815 2202 64269674
Accidental overdose 34.43 9.77 219 226637 33338 64238538
Impaired driving ability 34.31 9.77 60 226796 4594 64267282
Coronary artery disease 34.24 9.77 104 226752 60329 64211547
Extrapyramidal disorder 34.22 9.77 148 226708 19404 64252472
Obsessive-compulsive disorder 34.08 9.77 61 226795 4757 64267119
Weight increased 34.03 9.77 987 225869 212361 64059515
Epistaxis 33.92 9.77 204 226652 97927 64173949
Vision blurred 33.82 9.77 475 226381 89841 64182035
Aspergillus infection 33.82 9.77 8 226848 16371 64255505
Torticollis 33.79 9.77 40 226816 2137 64269739
Toxic encephalopathy 33.69 9.77 93 226763 9722 64262154
Pruritus 33.61 9.77 839 226017 311561 63960315
Migraine 33.21 9.77 352 226504 62325 64209551
Device interaction 33.17 9.77 24 226832 674 64271202
Lethargy 33.16 9.77 396 226460 72198 64199678
Parosmia 33.15 9.77 59 226797 4581 64267295
Musculoskeletal pain 33.07 9.77 160 226696 81134 64190742
Cytopenia 33.07 9.77 7 226849 15464 64256412
Accidental death 32.79 9.77 52 226804 3673 64268203
Hallucination, visual 32.59 9.77 188 226668 27646 64244230
Skin ulcer 32.48 9.77 66 226790 43908 64227968
Inflammation 32.45 9.77 119 226737 65181 64206695
Areflexia 32.40 9.77 61 226795 4946 64266930
Incoherent 32.33 9.77 75 226781 7043 64264833
Panic disorder 32.24 9.77 44 226812 2713 64269163
Broncholithiasis 32.16 9.77 14 226842 139 64271737
Libido decreased 31.85 9.77 59 226797 4725 64267151
Oromandibular dystonia 31.59 9.77 26 226830 887 64270989
COVID-19 31.53 9.77 120 226736 65020 64206856
Agoraphobia 31.12 9.77 21 226835 526 64271350
Haematemesis 31.05 9.77 75 226781 46924 64224952
Withdrawal arrhythmia 30.58 9.77 10 226846 40 64271836
Parasomnia 30.57 9.77 20 226836 475 64271401
Psychogenic seizure 30.54 9.77 35 226821 1806 64270070
Pathogen resistance 30.52 9.77 4 226852 12539 64259337
Anaphylactic shock 30.50 9.77 37 226819 30291 64241585
Muscle twitching 30.38 9.77 140 226716 18858 64253018
Irritable bowel syndrome 30.31 9.77 53 226803 37316 64234560
Right ventricular failure 30.31 9.77 19 226837 21452 64250424
Freezing phenomenon 30.16 9.77 32 226824 1514 64270362
Creatinine renal clearance decreased 29.86 9.77 7 226849 14414 64257462
Rectal haemorrhage 29.84 9.77 114 226742 61703 64210173
Basal cell carcinoma 29.58 9.77 39 226817 30799 64241077
Drug level above therapeutic 29.49 9.77 71 226785 6830 64265046
Schizoaffective disorder 29.46 9.77 32 226824 1555 64270321
Stoma site hypergranulation 29.46 9.77 18 226838 378 64271498
Drug ineffective for unapproved indication 29.40 9.77 199 226657 30934 64240942
Urinary tract discomfort 29.23 9.77 17 226839 325 64271551
Encephalitis toxic 29.01 9.77 16 226840 275 64271601
Pleurothotonus 28.85 9.77 38 226818 2264 64269612
Tubulointerstitial nephritis 28.73 9.77 40 226816 30869 64241007
Stoma site pain 28.65 9.77 27 226829 1106 64270770
Tinnitus 28.63 9.77 212 226644 33921 64237955
Drug diversion 28.58 9.77 27 226829 1109 64270767
Bruxism 28.40 9.77 48 226808 3576 64268300
Weight abnormal 28.09 9.77 27 226829 1134 64270742
Vessel puncture site erythema 27.92 9.77 6 226850 0 64271876
Apathy 27.87 9.77 95 226761 11137 64260739
Affect lability 27.77 9.77 82 226774 8908 64262968
Vomiting 27.76 9.77 1621 225235 549496 63722380
Adrenal insufficiency 27.69 9.77 23 226833 22464 64249412
Poor quality sleep 27.65 9.77 136 226720 18815 64253061
Feeling guilty 27.57 9.77 23 226833 800 64271076
Hyponatraemia 27.48 9.77 362 226494 147977 64123899
Urinary bladder rupture 27.44 9.77 11 226845 87 64271789
Urinary retention 27.33 9.77 279 226577 48922 64222954
Rhinitis allergic 27.20 9.77 76 226780 8002 64263874
Cholestasis 27.04 9.77 75 226781 44797 64227079
Arthritis 27.02 9.77 178 226678 83636 64188240
Hypoventilation 26.97 9.77 63 226793 5943 64265933
Hypertonia 26.94 9.77 65 226791 6260 64265616
Jaundice cholestatic 26.70 9.77 79 226777 8591 64263285
Band neutrophil percentage increased 26.69 9.77 17 226839 385 64271491
Anorgasmia 26.68 9.77 24 226832 925 64270951
Jaundice 26.41 9.77 85 226771 48427 64223449
Coma blister 26.39 9.77 14 226842 222 64271654
Treatment noncompliance 26.31 9.77 251 226605 43231 64228645
Hypervolaemia 26.17 9.77 60 226796 38225 64233651
Dyspnoea exertional 26.15 9.77 152 226704 73578 64198298
Hypomania 26.15 9.77 60 226796 5594 64266282
Cerebellar atrophy 26.14 9.77 25 226831 1043 64270833
Fear 26.12 9.77 140 226716 20031 64251845
Alveolar osteitis 25.94 9.77 17 226839 405 64271471
Stoma site extravasation 25.92 9.77 15 226841 284 64271592
Road traffic accident 25.81 9.77 191 226665 30554 64241322
Change in seizure presentation 25.55 9.77 15 226841 292 64271584
Cough 25.51 9.77 839 226017 301309 63970567
Oedema 25.42 9.77 204 226652 91731 64180145
Hypotonia 25.38 9.77 92 226764 11120 64260756
Bone erosion 25.29 9.77 5 226851 11590 64260286
Abdominal pain 25.07 9.77 873 225983 311502 63960374
Parkinsonian gait 24.92 9.77 22 226834 827 64271049
Bacteraemia 24.84 9.77 35 226821 26876 64245000
Hereditary angioedema 24.81 9.77 47 226809 3829 64268047
Panic reaction 24.75 9.77 48 226808 3979 64267897
Aplastic anaemia 24.72 9.77 9 226847 13911 64257965
Impulsive behaviour 24.59 9.77 38 226818 2625 64269251
Logorrhoea 24.48 9.77 48 226808 4011 64267865
Diverticulitis 24.44 9.77 63 226793 38555 64233321
Cerebral infarction 24.44 9.77 69 226787 40975 64230901
Gaze palsy 24.41 9.77 37 226819 2513 64269363
Emotional distress 24.33 9.77 213 226643 35825 64236051
Somnambulism 24.27 9.77 55 226801 5086 64266790
Psychiatric symptom 24.13 9.77 62 226794 6211 64265665
Suspected suicide 23.99 9.77 76 226780 8578 64263298
Pulmonary hypertension 23.90 9.77 75 226781 43064 64228812
Therapy non-responder 23.83 9.77 135 226721 65764 64206112
Ehlers-Danlos syndrome 23.66 9.77 11 226845 129 64271747
Enthesopathy 23.63 9.77 3 226853 9635 64262241
Stupor 23.58 9.77 60 226796 5975 64265901
Tachyphrenia 23.56 9.77 31 226825 1845 64270031
Disseminated intravascular coagulation 23.51 9.77 49 226807 32299 64239577
Dysstasia 23.50 9.77 151 226705 23064 64248812
Haematotoxicity 23.48 9.77 8 226848 12888 64258988
Pulmonary arterial hypertension 23.41 9.77 33 226823 25334 64246542
Bipolar I disorder 23.39 9.77 30 226826 1741 64270135
Stress 23.32 9.77 320 226536 60214 64211662
Post-traumatic neck syndrome 23.23 9.77 31 226825 1871 64270005
Kidney transplant rejection 23.22 9.77 3 226853 9508 64262368
Knee arthroplasty 23.09 9.77 37 226819 26962 64244914
Posterior reversible encephalopathy syndrome 23.07 9.77 28 226828 22918 64248958
Blood prolactin increased 22.85 9.77 43 226813 3485 64268391
Ill-defined disorder 22.74 9.77 79 226777 43973 64227903
Nephropathy toxic 22.72 9.77 17 226839 17497 64254379
Brain scan abnormal 22.47 9.77 24 226832 1144 64270732
Lymph node calcification 22.46 9.77 14 226842 305 64271571
Muscle disorder 22.30 9.77 52 226804 4899 64266977
Self-injurious ideation 22.01 9.77 40 226816 3157 64268719
Leukopenia 21.83 9.77 239 226617 101003 64170873
Blister 21.77 9.77 181 226675 80786 64191090
Failure to suspend medication 21.74 9.77 15 226841 390 64271486
Hip arthroplasty 21.52 9.77 26 226830 21325 64250551
Diffuse large B-cell lymphoma 21.51 9.77 5 226851 10356 64261520
Postmortem blood drug level abnormal 21.50 9.77 18 226838 629 64271247
Clostridium difficile infection 21.38 9.77 61 226795 36102 64235774
Substance dependence 21.38 9.77 16 226840 474 64271402
Concussion 21.35 9.77 69 226787 7869 64264007
Coma scale abnormal 21.30 9.77 68 226788 7706 64264170
Secretion discharge 21.27 9.77 91 226765 11873 64260003
Graft versus host disease 21.25 9.77 11 226845 13802 64258074
Haematoma 21.24 9.77 87 226769 46163 64225713
Drug tolerance 21.23 9.77 58 226798 6027 64265849
Dehydration 21.22 9.77 590 226266 216173 64055703
Hyperbilirubinaemia 21.19 9.77 26 226830 21179 64250697
Haemorrhage intracranial 21.13 9.77 32 226824 23852 64248024
Post transplant lymphoproliferative disorder 21.06 9.77 4 226852 9540 64262336
Partial seizures 21.02 9.77 65 226791 7242 64264634
Hyperreflexia 20.95 9.77 64 226792 7084 64264792
Cholangitis 20.92 9.77 6 226850 10796 64261080
Hyperthermia 20.87 9.77 109 226747 15441 64256435
Attention deficit hyperactivity disorder 20.80 9.77 36 226820 2734 64269142
Seizure cluster 20.77 9.77 14 226842 350 64271526
Urinary incontinence 20.56 9.77 206 226650 35945 64235931
Squamous cell carcinoma of skin 20.55 9.77 8 226848 11868 64260008
Fluid retention 20.55 9.77 124 226732 59482 64212394
Red blood cell sedimentation rate increased 20.51 9.77 50 226806 31185 64240691
Venoocclusive liver disease 20.47 9.77 5 226851 10010 64261866
Blepharospasm 20.47 9.77 40 226816 3335 64268541
Upper respiratory tract infection 20.35 9.77 161 226695 72624 64199252
Hyperkinesia 20.32 9.77 34 226822 2512 64269364
Metastases to liver 20.30 9.77 33 226823 23908 64247968
Rheumatic fever 20.29 9.77 4 226852 9290 64262586
Lymphopenia 20.26 9.77 37 226819 25620 64246256
Euphoric mood 20.24 9.77 60 226796 6531 64265345
Nephrectomy 20.23 9.77 25 226831 1397 64270479
Food craving 20.20 9.77 25 226831 1399 64270477
Dysphemia 20.18 9.77 38 226818 3081 64268795
Sensory loss 20.17 9.77 80 226776 10089 64261787
Mutism 20.16 9.77 30 226826 2004 64269872
Physical assault 20.12 9.77 26 226830 1520 64270356
Oropharyngeal oedema 20.02 9.77 12 226844 243 64271633
Liver function test increased 20.00 9.77 50 226806 30920 64240956
Liver disorder 20.00 9.77 108 226748 53243 64218633
Mobility decreased 19.99 9.77 199 226657 85641 64186235
Pseudomonas infection 19.99 9.77 20 226836 17863 64254013
Pneumonitis 19.98 9.77 100 226756 50265 64221611
Chronic kidney disease 19.70 9.77 121 226735 57798 64214078
Soft tissue injury 19.69 9.77 26 226830 1553 64270323
Stoma site infection 19.68 9.77 23 226833 1212 64270664
Blood creatine phosphokinase 19.63 9.77 9 226847 102 64271774
Impulse-control disorder 19.57 9.77 26 226830 1562 64270314
Hyperphagia 19.44 9.77 31 226825 2200 64269676
Staphylococcal infection 19.32 9.77 102 226754 50576 64221300
Liver function test abnormal 19.22 9.77 126 226730 59275 64212601
Postoperative respiratory failure 19.22 9.77 10 226846 152 64271724
Head titubation 19.22 9.77 19 226837 826 64271050
Sleep disorder 19.22 9.77 306 226550 59403 64212473
Physical abuse 19.19 9.77 6 226850 20 64271856
Medication error 19.19 9.77 264 226592 49702 64222174
White blood cell count decreased 19.15 9.77 416 226440 157421 64114455
Encephalopathy 19.14 9.77 302 226554 58517 64213359
Stoma site inflammation 19.14 9.77 16 226840 558 64271318
Atrial flutter 19.12 9.77 24 226832 19356 64252520
Sinusitis 19.07 9.77 380 226476 145548 64126328
Phaeochromocytoma malignant 19.06 9.77 8 226848 72 64271804
Aphasia 19.05 9.77 224 226632 40682 64231194
Prostate cancer 19.02 9.77 25 226831 19770 64252106
Allodynia 18.97 9.77 23 226833 1260 64270616
Acute coronary syndrome 18.96 9.77 24 226832 19286 64252590
Psychotic disorder due to a general medical condition 18.95 9.77 12 226844 269 64271607
Dependence 18.85 9.77 30 226826 2125 64269751
Staphylococcal sepsis 18.79 9.77 11 226845 12888 64258988
Post-traumatic stress disorder 18.76 9.77 44 226812 4161 64267715
Blood sodium decreased 18.75 9.77 172 226684 29310 64242566
Bladder pain 18.71 9.77 27 226829 1754 64270122
Muscle spasms 18.67 9.77 638 226218 140385 64131491
Compulsive shopping 18.66 9.77 18 226838 759 64271117
Hyperchloraemia 18.63 9.77 20 226836 959 64270917
Purpura fulminans 18.55 9.77 10 226846 164 64271712
Choreoathetosis 18.31 9.77 24 226832 1423 64270453
Spasmodic dysphonia 18.28 9.77 10 226846 169 64271707
Obsessive-compulsive personality disorder 18.28 9.77 9 226847 121 64271755
Tongue discolouration 18.14 9.77 38 226818 3330 64268546
Social anxiety disorder 18.10 9.77 14 226842 436 64271440
Onychophagia 17.99 9.77 8 226848 84 64271792
Carpal tunnel syndrome 17.94 9.77 106 226750 15722 64256154
Respiratory rate decreased 17.91 9.77 45 226811 4446 64267430
Drug eruption 17.86 9.77 66 226790 36070 64235806
Flat affect 17.85 9.77 27 226829 1830 64270046
Homicidal ideation 17.84 9.77 37 226819 3220 64268656
Brain malformation 17.84 9.77 7 226849 52 64271824
Heart rate increased 17.83 9.77 464 226392 98211 64173665
Congenital inguinal hernia 17.81 9.77 5 226851 10 64271866
Acute generalised exanthematous pustulosis 17.78 9.77 14 226842 14044 64257832
Rash maculo-papular 17.74 9.77 95 226761 46931 64224945
Epstein-Barr virus infection 17.70 9.77 11 226845 12477 64259399
Thrombosis 17.62 9.77 161 226695 70481 64201395
Hyperammonaemic encephalopathy 17.61 9.77 42 226814 4016 64267860
Angina pectoris 17.60 9.77 90 226766 44991 64226885
Osteoporosis 17.59 9.77 82 226774 41998 64229878
Prescribed underdose 17.52 9.77 116 226740 17899 64253977
Therapeutic response unexpected 17.47 9.77 111 226745 16890 64254986
Gambling disorder 17.45 9.77 27 226829 1867 64270009
Blood loss anaemia 17.37 9.77 14 226842 13878 64257998
Cerebral artery thrombosis 17.34 9.77 20 226836 1039 64270837
Influenza like illness 17.23 9.77 309 226547 61393 64210483
Tic 17.06 9.77 32 226824 2587 64269289
Neglect of personal appearance 17.00 9.77 9 226847 142 64271734
Injection site erythema 16.96 9.77 163 226693 70637 64201239
Haemoptysis 16.92 9.77 102 226754 48946 64222930
Uveitis 16.92 9.77 12 226844 12696 64259180
Rash erythematous 16.85 9.77 101 226755 48532 64223344
Injection site pruritus 16.84 9.77 72 226784 37754 64234122
Rapid eye movement sleep behaviour disorder 16.84 9.77 12 226844 329 64271547
Enuresis 16.84 9.77 33 226823 2757 64269119
Lymphadenopathy 16.69 9.77 96 226760 46590 64225286
Animal scratch 16.68 9.77 19 226837 974 64270902
End stage renal disease 16.63 9.77 8 226848 10467 64261409
Aspiration 16.58 9.77 109 226747 16776 64255100
BK virus infection 16.58 9.77 3 226853 7409 64264467
Reduced facial expression 16.57 9.77 28 226828 2085 64269791
Clonus 16.56 9.77 53 226803 6014 64265862
Hyperglycaemia 16.52 9.77 136 226720 60832 64211044
Oculogyric crisis 16.52 9.77 31 226825 2507 64269369
Cellulitis 16.45 9.77 231 226625 93426 64178450
Infantile spasms 16.42 9.77 11 226845 272 64271604
Intellectual disability 16.41 9.77 19 226837 991 64270885
Osteonecrosis 16.41 9.77 48 226808 28181 64243695
HIV peripheral neuropathy 16.37 9.77 6 226850 36 64271840
Obsessive thoughts 16.31 9.77 19 226837 998 64270878
Muscle contracture 16.26 9.77 28 226828 2117 64269759
Burning sensation 16.16 9.77 255 226601 49409 64222467
Dysphagia 16.15 9.77 491 226365 106321 64165555
Pericardial effusion 16.11 9.77 77 226779 39177 64232699
Niemann-Pick disease 16.10 9.77 6 226850 38 64271838
Transfusion 16.02 9.77 24 226832 17970 64253906
Learning disorder 15.73 9.77 14 226842 532 64271344
Electrocardiogram QRS complex shortened 15.68 9.77 15 226841 626 64271250
Antidepressant drug level above therapeutic 15.60 9.77 14 226842 538 64271338
Tunnel vision 15.60 9.77 19 226837 1046 64270830
Distractibility 15.58 9.77 15 226841 631 64271245
Labelled drug-drug interaction medication error 15.55 9.77 34 226822 22028 64249848
Myelocyte count increased 15.44 9.77 16 226840 736 64271140
Band neutrophil count increased 15.41 9.77 15 226841 640 64271236
Patient uncooperative 15.28 9.77 14 226842 553 64271323
Illness anxiety disorder 15.27 9.77 10 226846 238 64271638
Heat stroke 15.20 9.77 22 226834 1433 64270443
Haemophagocytic lymphohistiocytosis 15.19 9.77 24 226832 17585 64254291
Myelocyte percentage increased 15.16 9.77 10 226846 241 64271635
Cushingoid 15.14 9.77 4 226852 7599 64264277
Conversion disorder 15.13 9.77 24 226832 1695 64270181
Gastrointestinal hypomotility 14.99 9.77 24 226832 1709 64270167
Increased appetite 14.94 9.77 73 226783 10073 64261803
Decreased appetite 14.90 9.77 823 226033 280466 63991410
Periorbital swelling 14.90 9.77 25 226831 1851 64270025
Abulia 14.88 9.77 17 226839 874 64271002
Limb injury 14.88 9.77 137 226719 23368 64248508
Blood pressure fluctuation 14.85 9.77 114 226742 51757 64220119
Dysmetria 14.80 9.77 17 226839 879 64270997
Sensorimotor disorder 14.74 9.77 16 226840 777 64271099
Second primary malignancy 14.73 9.77 13 226843 12324 64259552
Respiratory dyskinesia 14.70 9.77 6 226850 50 64271826
Petit mal epilepsy 14.69 9.77 45 226811 4987 64266889
Drop attacks 14.69 9.77 18 226838 997 64270879
Sleep talking 14.69 9.77 18 226838 997 64270879
Paralysis 14.69 9.77 80 226776 11515 64260361
Formication 14.68 9.77 41 226815 4316 64267560
Renal hypertension 14.65 9.77 9 226847 191 64271685
Communication disorder 14.64 9.77 37 226819 3669 64268207
Blood urea increased 14.62 9.77 93 226763 44060 64227816
Oral candidiasis 14.59 9.77 38 226818 23174 64248702
Anticonvulsant drug level below therapeutic 14.56 9.77 18 226838 1006 64270870
Poisoning deliberate 14.53 9.77 89 226767 13369 64258507
Generalised anxiety disorder 14.52 9.77 25 226831 1890 64269986
Pain 14.50 9.77 1715 225141 551796 63720080
Psychotic behaviour 14.49 9.77 18 226838 1011 64270865
Mental disability 14.49 9.77 6 226850 52 64271824
Social avoidant behaviour 14.49 9.77 42 226814 4515 64267361
Pneumonia bacterial 14.44 9.77 19 226837 15016 64256860
Retinal detachment 14.43 9.77 5 226851 7971 64263905
Postictal paralysis 14.41 9.77 11 226845 336 64271540
Hypoalbuminaemia 14.39 9.77 25 226831 17649 64254227
Metabolic acidosis 14.32 9.77 170 226686 70788 64201088
Blood test abnormal 14.23 9.77 86 226770 12857 64259019
Cardiac failure chronic 14.21 9.77 7 226849 9034 64262842
Device dislocation 14.20 9.77 125 226731 21053 64250823
Nephrotic syndrome 14.16 9.77 8 226848 9559 64262317
Dermatitis acneiform 14.10 9.77 6 226850 8437 64263439
Peroneal nerve palsy 14.09 9.77 46 226810 5275 64266601
Affective disorder 14.06 9.77 53 226803 6527 64265349
Abdominal pain upper 14.05 9.77 489 226367 174541 64097335
Sexual abuse 14.03 9.77 8 226848 147 64271729
Priapism 14.01 9.77 38 226818 3932 64267944
Stoma site irritation 13.97 9.77 9 226847 208 64271668
Adverse drug reaction 13.93 9.77 98 226758 45366 64226510
Erythema multiforme 13.92 9.77 21 226835 15680 64256196
Dysmorphism 13.91 9.77 13 226843 527 64271349
Candida infection 13.87 9.77 60 226796 31359 64240517
Escherichia sepsis 13.84 9.77 4 226852 7161 64264715
Pancreatitis acute 13.82 9.77 91 226765 42764 64229112
Terminal insomnia 13.80 9.77 17 226839 947 64270929
Accidental poisoning 13.79 9.77 21 226835 1432 64270444
Antidepressant drug level increased 13.78 9.77 11 226845 359 64271517
Suicidal behaviour 13.75 9.77 31 226825 2856 64269020
Hepatic cirrhosis 13.68 9.77 47 226809 26251 64245625
Product use in unapproved indication 13.60 9.77 496 226360 176122 64095754
Postmortem blood drug level increased 13.53 9.77 15 226841 746 64271130
Hypersexuality 13.51 9.77 21 226835 1458 64270418
Staphylococcal bacteraemia 13.50 9.77 10 226846 10345 64261531
Gout 13.50 9.77 35 226821 21378 64250498
Hypnopompic hallucination 13.49 9.77 6 226850 63 64271813
Brain injury 13.47 9.77 70 226786 9895 64261981
Motor dysfunction 13.43 9.77 77 226779 11296 64260580
Sleep disorder due to a general medical condition 13.40 9.77 61 226795 8173 64263703
Abscess 13.40 9.77 30 226826 19274 64252602
Incorrect route of product administration 13.36 9.77 133 226723 23165 64248711
Oropharyngeal pain 13.30 9.77 226 226630 88641 64183235
Wrong patient received product 13.27 9.77 36 226820 3726 64268150
Urosepsis 13.26 9.77 37 226819 22057 64249819
Polyarthritis 13.16 9.77 9 226847 9706 64262170
Poverty of speech 13.14 9.77 13 226843 566 64271310
Disorganised speech 13.12 9.77 22 226834 1628 64270248
Ketosis-prone diabetes mellitus 13.11 9.77 4 226852 12 64271864
Locomotive syndrome 13.11 9.77 4 226852 12 64271864
Laryngomalacia 13.11 9.77 4 226852 12 64271864
Blood bicarbonate decreased 13.01 9.77 42 226814 4787 64267089
Cyanosis 12.96 9.77 127 226729 22028 64249848
Metastases to central nervous system 12.93 9.77 18 226838 13894 64257982
Pneumothorax 12.93 9.77 43 226813 24255 64247621
Psoriatic arthropathy 12.92 9.77 94 226762 43187 64228689
Forced expiratory volume decreased 12.81 9.77 53 226803 6814 64265062
Helplessness 12.81 9.77 10 226846 316 64271560
Cystitis haemorrhagic 12.75 9.77 6 226850 7950 64263926
Ulcer 12.71 9.77 40 226816 22950 64248926
Eye movement disorder 12.71 9.77 54 226802 7025 64264851
Bacterial infection 12.70 9.77 45 226811 24905 64246971
Acute hepatic failure 12.70 9.77 48 226808 26064 64245812
Heparin-induced thrombocytopenia 12.68 9.77 7 226849 8472 64263404
Peripheral pulse decreased 12.64 9.77 5 226851 38 64271838
Glossopharyngeal nerve disorder 12.64 9.77 5 226851 38 64271838
Gastric ulcer 12.59 9.77 59 226797 30175 64241701
Haematuria traumatic 12.53 9.77 8 226848 182 64271694
Death 12.49 9.77 1907 224949 480798 63791078
Pupillary reflex impaired 12.47 9.77 31 226825 3042 64268834
Oral pain 12.45 9.77 52 226804 27441 64244435
Akinesia 12.43 9.77 31 226825 3048 64268828
Bulbar palsy 12.43 9.77 9 226847 253 64271623
Haemoglobin urine 12.41 9.77 7 226849 126 64271750
Intensive care unit acquired weakness 12.39 9.77 22 226834 1705 64270171
Somatic symptom disorder 12.39 9.77 23 226833 1845 64270031
Tenderness 12.39 9.77 32 226824 19570 64252306
Pulmonary tuberculosis 12.34 9.77 5 226851 7239 64264637
Bradycardia 12.33 9.77 521 226335 117698 64154178
Pneumonia fungal 12.33 9.77 8 226848 8869 64263007
Postmortem blood drug level 12.31 9.77 9 226847 257 64271619
Sudden unexplained death in epilepsy 12.30 9.77 13 226843 612 64271264
Barotrauma 12.23 9.77 8 226848 190 64271686
Skin toxicity 12.19 9.77 4 226852 6598 64265278
Polyneuropathy 12.17 9.77 33 226823 19861 64252015
Peritonitis 12.17 9.77 46 226810 24977 64246899
Duodenal ulcer 12.14 9.77 20 226836 14415 64257461
Cluster headache 12.14 9.77 15 226841 838 64271038
Lupus-like syndrome 12.11 9.77 8 226848 8783 64263093
Petechiae 12.08 9.77 30 226826 18596 64253280
Lower gastrointestinal haemorrhage 12.02 9.77 19 226837 13920 64257956
Alcohol abuse 12.00 9.77 41 226815 4811 64267065
Asterixis 11.97 9.77 26 226830 2337 64269539
Poor feeding infant 11.94 9.77 7 226849 136 64271740
Feeling drunk 11.92 9.77 37 226819 4130 64267746
Localised infection 11.90 9.77 60 226796 30101 64241775
Anal spasm 11.89 9.77 3 226853 3 64271873
Chemical burn of gastrointestinal tract 11.89 9.77 3 226853 3 64271873
Cerebral atrophy 11.88 9.77 54 226802 7231 64264645
Escherichia infection 11.86 9.77 22 226834 15146 64256730
Diabetes mellitus inadequate control 11.86 9.77 37 226819 21284 64250592
Hyperuricaemia 11.85 9.77 11 226845 10180 64261696
Circulatory collapse 11.71 9.77 70 226786 33662 64238214
Cardiac infection 11.70 9.77 9 226847 278 64271598
Drug level increased 11.67 9.77 177 226679 34019 64237857
Excessive eye blinking 11.66 9.77 18 226838 1242 64270634
Product complaint 11.64 9.77 77 226779 11877 64259999
Autoimmune hepatitis 11.59 9.77 11 226845 10073 64261803
Choking 11.58 9.77 70 226786 10468 64261408
Parotid gland enlargement 11.55 9.77 14 226842 767 64271109
Device expulsion 11.53 9.77 37 226819 21099 64250777
Deafness neurosensory 11.53 9.77 4 226852 6370 64265506
Haemorrhage 11.48 9.77 203 226653 79148 64192728
Organising pneumonia 11.48 9.77 9 226847 9046 64262830
Mouth ulceration 11.44 9.77 67 226789 32377 64239499
Asthma 11.41 9.77 426 226430 94799 64177077
Medical device site erosion 11.37 9.77 5 226851 51 64271825
Inappropriate affect 11.36 9.77 18 226838 1270 64270606
Congenital knee deformity 11.36 9.77 4 226852 21 64271855
Chest discomfort 11.36 9.77 316 226540 115790 64156086
Developmental delay 11.31 9.77 16 226840 1021 64270855
Anhidrosis 11.27 9.77 8 226848 218 64271658
Left ventricular dysfunction 11.24 9.77 27 226829 16927 64254949
Brain oedema 11.24 9.77 123 226733 21952 64249924
Embolism 11.21 9.77 16 226840 12219 64259657
Impaired self-care 11.20 9.77 25 226831 2288 64269588
Metastases to lung 11.19 9.77 23 226833 15241 64256635
COVID-19 pneumonia 11.17 9.77 26 226830 16478 64255398
Urine oxalate increased 11.14 9.77 8 226848 222 64271654
Abnormal sleep-related event 11.10 9.77 14 226842 799 64271077
Body height increased 11.10 9.77 6 226850 99 64271777
Snoring 11.09 9.77 39 226817 4643 64267233
Fibromyalgia 11.08 9.77 182 226674 35549 64236327
Dysgraphia 11.05 9.77 32 226824 3439 64268437
Febrile bone marrow aplasia 11.04 9.77 14 226842 11241 64260635
Oesophagitis 11.02 9.77 39 226817 21591 64250285
Ammonia abnormal 11.01 9.77 7 226849 158 64271718
Dairy intolerance 10.96 9.77 5 226851 56 64271820
Dizziness 10.95 9.77 1698 225158 428465 63843411
Flight of ideas 10.93 9.77 13 226843 698 64271178
Hypoxic-ischaemic encephalopathy 10.92 9.77 52 226804 7100 64264776
Chronic spontaneous urticaria 10.87 9.77 11 226845 492 64271384
Enteritis 10.86 9.77 16 226840 12061 64259815
Cataplexy 10.85 9.77 14 226842 817 64271059
Decreased activity 10.81 9.77 52 226804 7128 64264748
Iron deficiency anaemia 10.80 9.77 40 226816 21849 64250027
Anticonvulsant drug level increased 10.75 9.77 25 226831 2352 64269524
Dissociative identity disorder 10.73 9.77 5 226851 59 64271817
Large intestine operation 10.69 9.77 3 226853 6 64271870
CYP2D6 polymorphism 10.69 9.77 3 226853 6 64271870
Neuropsychiatric symptoms 10.67 9.77 15 226841 951 64270925
Full blood count decreased 10.67 9.77 42 226814 22540 64249336
Nodal rhythm 10.64 9.77 28 226828 2846 64269030
Blood growth hormone increased 10.61 9.77 12 226844 610 64271266
Drug resistance 10.59 9.77 76 226780 35026 64236850
Sexual dysfunction 10.58 9.77 48 226808 6423 64265453
Thrombocytosis 10.57 9.77 6 226850 7150 64264726
Sternal fracture 10.56 9.77 24 226832 2223 64269653
Sebaceous gland infection 10.54 9.77 6 226850 110 64271766
Blood uric acid increased 10.49 9.77 8 226848 8155 64263721
Intestinal perforation 10.46 9.77 24 226832 15289 64256587
Orthopnoea 10.46 9.77 10 226846 9124 64262752
Drug detoxification 10.43 9.77 8 226848 246 64271630
Narcotic bowel syndrome 10.43 9.77 8 226848 246 64271630
Device related infection 10.40 9.77 64 226792 30562 64241314
Nail disorder 10.40 9.77 9 226847 8615 64263261
Alcoholism 10.39 9.77 31 226825 3386 64268490
Colon cancer 10.39 9.77 18 226838 12721 64259155
Sensitivity to weather change 10.38 9.77 49 226807 6665 64265211
Stoma site pruritus 10.37 9.77 3 226853 7 64271869
Homeless 10.35 9.77 6 226850 114 64271762
Acute respiratory failure 10.32 9.77 119 226737 49815 64222061
Pyelonephritis 10.30 9.77 29 226827 17237 64254639
Therapy interrupted 10.29 9.77 36 226820 20000 64251876
Chest pain 10.29 9.77 703 226153 235277 64036599
Facial bones fracture 10.29 9.77 36 226820 4276 64267600
Anticonvulsant drug level decreased 10.27 9.77 21 226835 1809 64270067
Cataract 10.27 9.77 123 226733 51139 64220737
Systemic candida 10.25 9.77 3 226853 5326 64266550
Infective pulmonary exacerbation of cystic fibrosis 10.25 9.77 16 226840 11780 64260096
Gastrointestinal toxicity 10.23 9.77 3 226853 5319 64266557
Initial insomnia 10.21 9.77 44 226812 5760 64266116
Tonic clonic movements 10.20 9.77 22 226834 1967 64269909
Fear of injection 10.20 9.77 4 226852 5908 64265968
Device use error 10.18 9.77 5 226851 6466 64265410
Osteoarthritis 10.16 9.77 159 226697 63177 64208699
Gastric haemorrhage 10.15 9.77 20 226836 13461 64258415
Drug tolerance decreased 10.15 9.77 6 226850 6992 64264884
Monocyte percentage increased 10.12 9.77 22 226834 1978 64269898
Transcription medication error 10.11 9.77 9 226847 342 64271534
Trismus 10.08 9.77 39 226817 4862 64267014
Product quality issue 10.08 9.77 154 226702 29645 64242231
Accidental exposure to product by child 10.01 9.77 25 226831 2460 64269416
Illusion 10.00 9.77 19 226837 1551 64270325
Metabolic surgery 9.99 9.77 14 226842 885 64270991
Injection site swelling 9.99 9.77 95 226761 41258 64230618
Pneumatosis intestinalis 9.95 9.77 3 226853 5226 64266650
Colitis microscopic 9.92 9.77 7 226849 7425 64264451
Confabulation 9.85 9.77 10 226846 449 64271427
Irregular sleep phase 9.85 9.77 5 226851 72 64271804
Creatine urine increased 9.83 9.77 3 226853 9 64271867
Toxic leukoencephalopathy 9.80 9.77 14 226842 901 64270975
Flank pain 9.80 9.77 27 226829 16162 64255714
Enterocolitis 9.79 9.77 17 226839 12001 64259875

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Tricuspid valve incompetence 33.40 27.86 12 318 61 84287

Pharmacologic Action:

SourceCodeDescription
ATC N03AE01 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Benzodiazepine derivatives
FDA CS M0002356 Benzodiazepines
CHEBI has role CHEBI:35474 anti-anxiety agents
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:50268 GABA modulators
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D018377 Neurotransmitter Agents
FDA EPC N0000175694 Benzodiazepine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Myoclonic seizure indication 37356005
Atonic seizure indication 42365007
Absence seizure indication 79631006
Lennox-Gastaut syndrome indication 230418006
Panic disorder indication 371631005 DOID:594
Akathisia off-label use 285145004
Manic Bipolar Disorder Adjunct Treatment off-label use
Suicidal thoughts contraindication 6471006
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Hepatic failure contraindication 59927004
Substance abuse contraindication 66214007
Sleep apnea contraindication 73430006 DOID:0050847
Decreased respiratory function contraindication 80954004
Open-angle glaucoma contraindication 84494001 DOID:1067
Kidney disease contraindication 90708001 DOID:557
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Syncope contraindication 271594007
Pregnancy, function contraindication 289908002
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.65 acidic
pKa2 1.65 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 8.07 WOMBAT-PK CHEMBL
GABA-A receptor; anion channel Ion channel Ki 9.07 CHEMBL
GABA-A receptor; anion channel Ion channel IC50 8.77 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 9.07 CHEMBL

External reference:

IDSource
4017791 VUID
N0000146152 NUI
D00280 KEGG_DRUG
202585 RXNORM
4017791 VANDF
C0009011 UMLSCUI
CHEBI:3756 CHEBI
CHEMBL452 ChEMBL_ID
DB01068 DRUGBANK_ID
D002998 MESH_DESCRIPTOR_UI
2802 PUBCHEM_CID
6963 IUPHAR_LIGAND_ID
2765 INN_ID
5PE9FDE8GB UNII
1345 MMSL
377 MMSL
4477 MMSL
d00197 MMSL
001635 NDDF
387383007 SNOMEDCT_US
69708003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Klonopin HUMAN PRESCRIPTION DRUG LABEL 1 0004-0058 TABLET 1 mg ORAL NDA 30 sections
Klonopin HUMAN PRESCRIPTION DRUG LABEL 1 0004-0068 TABLET 0.50 mg ORAL NDA 30 sections
Klonopin HUMAN PRESCRIPTION DRUG LABEL 1 0004-0098 TABLET 2 mg ORAL NDA 30 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-0832 TABLET 0.50 mg ORAL ANDA 20 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3212 TABLET 1 mg ORAL ANDA 20 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3213 TABLET 2 mg ORAL ANDA 20 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9290 TABLET, ORALLY DISINTEGRATING 0.13 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9291 TABLET, ORALLY DISINTEGRATING 0.25 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9292 TABLET, ORALLY DISINTEGRATING 0.50 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9293 TABLET, ORALLY DISINTEGRATING 1 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9293 TABLET, ORALLY DISINTEGRATING 1 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-9294 TABLET, ORALLY DISINTEGRATING 2 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-3003 TABLET 0.50 mg ORAL ANDA 24 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-3004 TABLET 1 mg ORAL ANDA 24 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-3005 TABLET 2 mg ORAL ANDA 24 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0094 TABLET, ORALLY DISINTEGRATING 0.13 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0095 TABLET, ORALLY DISINTEGRATING 0.25 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0096 TABLET, ORALLY DISINTEGRATING 0.50 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0097 TABLET, ORALLY DISINTEGRATING 1 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0098 TABLET, ORALLY DISINTEGRATING 2 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8234 TABLET 0.50 mg ORAL ANDA 26 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8235 TABLET 1 mg ORAL ANDA 26 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8236 TABLET 2 mg ORAL ANDA 26 sections
CLONAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 16590-058 TABLET 0.50 mg ORAL ANDA 23 sections
CLONAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 16590-059 TABLET 1 mg ORAL ANDA 23 sections
CLONAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 16590-481 TABLET 2 mg ORAL ANDA 23 sections
KLONOPIN HUMAN PRESCRIPTION DRUG LABEL 1 16590-693 TABLET 0.50 mg ORAL NDA 25 sections
KLONOPIN HUMAN PRESCRIPTION DRUG LABEL 1 16590-935 TABLET 1 mg ORAL NDA 26 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 16729-136 TABLET 0.50 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 16729-137 TABLET 1 mg ORAL ANDA 27 sections