clonazepam Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 703 1622-61-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clonazepam
  • lonazep
  • klonopin
An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
  • Molecular weight: 315.71
  • Formula: C15H10ClN3O3
  • CLOGP: 2.38
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 87.28
  • ALOGS: -4.47
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
8 mg O
8 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.42 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 98 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.90 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.88 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.15 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 38 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
June 4, 1975 FDA ROCHE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1871.71 9.73 2446 163998 143474 46376144
Toxicity to various agents 702.21 9.73 1994 164450 209772 46309846
Suicide attempt 475.83 9.73 767 165677 54269 46465349
Drug abuse 448.28 9.73 808 165636 62600 46457018
Anxiety 389.03 9.73 1477 164967 180480 46339138
Respiratory arrest 372.89 9.73 528 165916 33288 46486330
Suicidal ideation 363.97 9.73 691 165753 55691 46463927
Intentional overdose 352.13 9.73 740 165704 64204 46455414
Rheumatoid arthritis 351.08 9.73 211 166233 240004 46279614
Depression 318.56 9.73 1325 165119 168779 46350839
Seizure 303.56 9.73 1047 165397 122007 46397611
Cardio-respiratory arrest 301.36 9.73 662 165782 59207 46460411
Sopor 279.19 9.73 349 166095 19479 46500139
Overdose 272.97 9.73 892 165552 101087 46418531
Somnolence 236.32 9.73 1144 165300 155377 46364241
Drug withdrawal syndrome 231.57 9.73 378 166066 27006 46492612
Cardiac arrest 201.25 9.73 744 165700 89655 46429963
Irritability 195.71 9.73 362 166082 28584 46491034
Contraindicated product administered 194.59 9.73 27 166417 79920 46439698
Psychotic disorder 192.27 9.73 313 166131 22308 46497310
Acute kidney injury 187.47 9.73 347 166097 235508 46284110
Insomnia 185.40 9.73 1112 165332 163812 46355806
Intentional self-injury 175.80 9.73 312 166132 23854 46495764
Synovitis 168.23 9.73 13 166431 61062 46458556
Tremor 167.11 9.73 835 165609 114804 46404814
Drug dependence 153.95 9.73 264 166180 19637 46499981
Drug hypersensitivity 149.55 9.73 413 166031 243412 46276206
Panic attack 149.38 9.73 263 166181 19979 46499639
Febrile neutropenia 139.57 9.73 82 166362 94545 46425073
Poisoning 138.93 9.73 208 166236 13786 46505832
Anaemia 135.68 9.73 463 165981 255316 46264302
Schizophrenia 130.60 9.73 157 166287 8411 46511207
Agitation 129.95 9.73 464 165980 54951 46464667
Stubbornness 127.54 9.73 43 166401 190 46519428
Hypomania 126.11 9.73 113 166331 4275 46515343
Withdrawal syndrome 124.09 9.73 228 166216 17906 46501712
Treatment failure 120.73 9.73 93 166351 92994 46426624
Drug intolerance 117.01 9.73 216 166228 146833 46372785
Anger 114.58 9.73 174 166270 11678 46507940
Intentional product misuse 111.68 9.73 396 166048 46732 46472886
Sedation 110.31 9.73 249 166195 22661 46496957
Abnormal behaviour 107.17 9.73 234 166210 20824 46498794
Neutropenia 105.59 9.73 220 166224 142984 46376634
Diarrhoea 104.97 9.73 1387 165057 558215 45961403
Mental disorder 101.65 9.73 238 166206 22187 46497431
Unresponsive to stimuli 101.31 9.73 298 166146 31876 46487742
Aggression 99.43 9.73 238 166206 22506 46497112
Thrombocytopenia 98.00 9.73 189 166255 126392 46393226
Mania 97.53 9.73 154 166290 10692 46508926
Neuroleptic malignant syndrome 97.37 9.73 156 166288 10966 46508652
Crying 96.52 9.73 225 166219 20916 46498702
Systemic lupus erythematosus 93.97 9.73 58 166386 65122 46454496
Sepsis 92.84 9.73 218 166226 135796 46383822
Atrial fibrillation 92.71 9.73 141 166303 103449 46416169
Rash 92.70 9.73 819 165625 355693 46163925
Disturbance in attention 92.48 9.73 285 166159 31275 46488343
Restless legs syndrome 91.02 9.73 185 166259 15658 46503960
Thinking abnormal 90.54 9.73 141 166303 9673 46509945
Paranoia 89.18 9.73 146 166298 10451 46509167
Amnesia 87.88 9.73 337 166107 41294 46478324
Memory impairment 87.09 9.73 522 165922 76815 46442803
Depressed level of consciousness 86.80 9.73 368 166076 47201 46472417
Infusion related reaction 85.61 9.73 143 166301 101065 46418553
Joint swelling 85.01 9.73 305 166139 165768 46353850
Feeling abnormal 84.63 9.73 747 165697 124313 46395305
Ataxia 84.02 9.73 166 166278 13764 46505854
Weight increased 83.83 9.73 926 165518 163547 46356071
Cardiac failure 83.58 9.73 97 166347 79851 46439767
Mood altered 82.10 9.73 158 166286 12849 46506769
Speech disorder 81.51 9.73 299 166145 35868 46483750
Dyspnoea 79.85 9.73 1326 165118 514222 46005396
Drug withdrawal convulsions 79.29 9.73 53 166391 1288 46518330
Dyskinesia 79.06 9.73 255 166189 28670 46490948
Tardive dyskinesia 79.02 9.73 115 166329 7428 46512190
Dystonia 78.87 9.73 143 166301 11114 46508504
Nervousness 75.99 9.73 249 166195 28226 46491392
Interstitial lung disease 72.38 9.73 52 166392 53897 46465721
Hallucination 72.28 9.73 361 166083 49590 46470028
Hyperhidrosis 71.40 9.73 554 165890 88754 46430864
Pancytopenia 71.18 9.73 121 166323 84937 46434681
Infection 69.25 9.73 244 166200 133348 46386270
Malignant neoplasm progression 68.70 9.73 78 166366 64848 46454770
Gastrointestinal haemorrhage 67.60 9.73 107 166337 77266 46442352
Pleural effusion 67.59 9.73 120 166324 82832 46436786
Disease progression 67.48 9.73 140 166304 91160 46428458
Hand deformity 66.92 9.73 20 166424 34554 46485064
Epilepsy 66.44 9.73 211 166233 23527 46496091
Multiple sclerosis relapse 66.38 9.73 312 166132 41813 46477805
Hypersomnia 64.74 9.73 159 166285 15280 46504338
Balance disorder 64.21 9.73 422 166022 64099 46455519
Bradyphrenia 63.84 9.73 94 166350 6136 46513482
Akathisia 63.19 9.73 105 166339 7609 46512009
Plasma cell myeloma 62.16 9.73 41 166403 44437 46475181
Arthralgia 61.97 9.73 921 165523 363682 46155936
Nightmare 61.37 9.73 163 166281 16435 46503183
Product substitution issue 61.13 9.73 153 166291 14878 46504740
Renal impairment 61.13 9.73 107 166337 74265 46445353
General physical health deterioration 60.96 9.73 210 166234 115559 46404059
Serotonin syndrome 60.38 9.73 207 166237 24013 46495605
Mucosal inflammation 58.55 9.73 33 166411 38943 46480675
Lactic acidosis 58.12 9.73 24 166420 33885 46485733
Bipolar disorder 57.87 9.73 97 166347 7080 46512538
Cardiac failure congestive 56.43 9.73 155 166289 91595 46428023
Drooling 54.23 9.73 62 166382 3147 46516471
Maternal exposure during pregnancy 53.33 9.73 187 166257 102362 46417256
Glossodynia 52.99 9.73 48 166396 44325 46475293
Bone marrow failure 52.49 9.73 20 166424 29649 46489969
Hallucination, auditory 51.88 9.73 117 166327 10639 46508979
Respiratory depression 51.36 9.73 122 166322 11478 46508140
Arthropathy 50.67 9.73 145 166299 84555 46435063
Myocardial stunning 49.98 9.73 20 166424 155 46519463
Status epilepticus 49.39 9.73 135 166309 13844 46505774
Drug screen negative 49.05 9.73 25 166419 358 46519260
Hypersensitivity 48.50 9.73 325 166119 149996 46369622
Haemoglobin decreased 48.30 9.73 266 166178 128683 46390935
Mood swings 47.82 9.73 147 166297 16105 46503513
Muscle rigidity 47.65 9.73 108 166336 9853 46509765
Granulocytopenia 46.21 9.73 74 166370 5199 46514419
Peripheral swelling 46.03 9.73 352 166092 157719 46361899
Dysarthria 46.02 9.73 259 166185 37239 46482379
Mydriasis 45.65 9.73 110 166334 10443 46509175
Feeling of despair 45.11 9.73 43 166401 1762 46517856
Swelling 44.93 9.73 260 166184 124251 46395367
Off label use 44.89 9.73 1022 165422 378819 46140799
Alopecia 44.82 9.73 367 166077 162047 46357571
Multiple sclerosis 44.60 9.73 191 166253 24600 46495018
Herpes zoster 43.75 9.73 112 166332 67760 46451858
Blood creatinine increased 43.39 9.73 134 166310 76269 46443349
Platelet count decreased 43.37 9.73 196 166248 99828 46419790
Restlessness 43.14 9.73 193 166251 25331 46494287
Stomatitis 43.03 9.73 114 166330 68183 46451435
Vision blurred 42.50 9.73 453 165991 79255 46440363
Exposure via ingestion 42.49 9.73 57 166387 3410 46516208
Renal failure 42.17 9.73 235 166209 113359 46406259
Therapeutic response unexpected 42.06 9.73 137 166307 15479 46504139
Lower respiratory tract infection 41.95 9.73 83 166361 55006 46464612
Palmar-plantar erythrodysaesthesia syndrome 41.12 9.73 11 166433 20440 46499178
Melaena 41.02 9.73 24 166420 27748 46491870
Bradykinesia 40.87 9.73 60 166384 3906 46515712
Lethargy 40.64 9.73 317 166127 50854 46468764
Delusion 40.48 9.73 109 166335 11079 46508539
Myocardial depression 39.83 9.73 24 166420 484 46519134
Dysphoria 39.66 9.73 64 166380 4525 46515093
Personality disorder 39.15 9.73 52 166392 3081 46516537
Osteonecrosis of jaw 38.99 9.73 39 166405 34363 46485255
Decorticate posture 38.98 9.73 21 166423 339 46519279
Loss of consciousness 38.73 9.73 571 165873 107667 46411951
Angioedema 38.71 9.73 50 166394 39292 46480326
Confusional state 38.64 9.73 792 165652 159100 46360518
Sluggishness 38.62 9.73 64 166380 4627 46514991
Substance abuse 38.62 9.73 60 166384 4107 46515511
Gastric pH decreased 38.33 9.73 21 166423 351 46519267
Hyperkalaemia 38.10 9.73 77 166367 50632 46468986
Parkinsonism 37.82 9.73 86 166358 7862 46511756
Hyponatraemia 36.33 9.73 212 166232 101120 46418498
Pericarditis 36.31 9.73 20 166424 23907 46495711
Head injury 36.30 9.73 179 166265 24457 46495161
Depressed mood 36.27 9.73 223 166221 33096 46486522
Panic disorder 35.91 9.73 45 166399 2516 46517102
Breast hyperplasia 35.49 9.73 18 166426 255 46519363
Atonic seizures 35.45 9.73 24 166420 596 46519022
Impaired driving ability 35.28 9.73 58 166386 4166 46515452
Pneumocystis jirovecii pneumonia 35.15 9.73 6 166438 15242 46504376
Psychomotor hyperactivity 35.13 9.73 94 166350 9519 46510099
Drug interaction 35.00 9.73 960 165484 202134 46317484
Abdominal discomfort 35.00 9.73 357 166087 150808 46368810
Major depression 34.78 9.73 75 166369 6615 46513003
Pulmonary arterial hypertension 34.76 9.73 25 166419 25903 46493715
Dissociation 34.69 9.73 38 166406 1839 46517779
Myocardial infarction 34.46 9.73 205 166239 97323 46422295
Jaundice cholestatic 34.11 9.73 63 166381 4966 46514652
Leukopenia 33.95 9.73 127 166317 68216 46451402
Neutrophil count decreased 33.43 9.73 65 166379 43361 46476257
Gait disturbance 33.29 9.73 714 165730 144549 46375069
Catatonia 33.25 9.73 53 166391 3709 46515909
Coma 33.17 9.73 336 166108 58013 46461605
Abnormal dreams 33.11 9.73 96 166348 10183 46509435
Emotional disorder 33.08 9.73 108 166336 12216 46507402
Hypercalcaemia 32.80 9.73 17 166427 21029 46498589
Cogwheel rigidity 32.59 9.73 33 166411 1457 46518161
Stress 32.32 9.73 303 166141 51248 46468370
Adjustment disorder with mixed anxiety and depressed mood 32.31 9.73 12 166432 74 46519544
Septic shock 31.84 9.73 103 166341 57790 46461828
Coma blister 31.80 9.73 14 166430 141 46519477
Electrocardiogram QT prolonged 30.85 9.73 299 166145 51026 46468592
Cytomegalovirus infection 30.84 9.73 13 166431 18131 46501487
Mental status changes 30.82 9.73 237 166207 37851 46481767
Road traffic accident 30.65 9.73 166 166278 23525 46496093
Anaphylactic reaction 30.26 9.73 93 166351 53019 46466599
Cognitive disorder 30.12 9.73 230 166214 36653 46482965
Autonomic nervous system imbalance 29.91 9.73 40 166404 2386 46517232
Product complaint 29.79 9.73 103 166341 11998 46507620
Disorientation 29.47 9.73 229 166215 36689 46482929
Vomiting 29.09 9.73 1319 165125 451475 46068143
Galactorrhoea 28.87 9.73 50 166394 3747 46515871
Bruxism 28.74 9.73 44 166400 2973 46516645
Hypocalcaemia 28.52 9.73 32 166412 26753 46492865
Developmental glaucoma 28.19 9.73 10 166434 53 46519565
Drug screen positive 27.98 9.73 50 166394 3841 46515777
Drug use disorder 27.64 9.73 41 166403 2694 46516924
Incoherent 27.49 9.73 54 166390 4458 46515160
Skin ulcer 27.30 9.73 46 166398 32412 46487206
Device expulsion 27.10 9.73 35 166409 27507 46492111
Hyperprolactinaemia 26.87 9.73 42 166402 2890 46516728
Dopamine dysregulation syndrome 26.85 9.73 15 166429 261 46519357
Obsessive-compulsive disorder 26.65 9.73 44 166400 3171 46516447
Right ventricular failure 26.60 9.73 12 166432 16081 46503537
Migraine 26.46 9.73 373 166071 69653 46449965
Urinary bladder rupture 26.41 9.73 12 166432 131 46519487
Nystagmus 26.38 9.73 61 166383 5638 46513980
Muscle twitching 26.36 9.73 113 166331 14559 46505059
Pneumonia 26.27 9.73 1086 165358 375234 46144384
Muscle spasms 25.94 9.73 598 165846 122515 46397103
Affect lability 25.92 9.73 75 166369 7945 46511673
C-reactive protein increased 25.88 9.73 114 166330 58476 46461142
Pleurothotonus 25.84 9.73 26 166418 1139 46518479
Derealisation 25.73 9.73 22 166422 781 46518837
Fear 25.63 9.73 120 166324 16052 46503566
Anticonvulsant drug level above therapeutic 25.44 9.73 18 166426 481 46519137
Electroencephalogram abnormal 25.42 9.73 47 166397 3707 46515911
Persecutory delusion 25.39 9.73 38 166406 2517 46517101
Upper gastrointestinal haemorrhage 25.38 9.73 14 166430 16724 46502894
Multiple-drug resistance 25.28 9.73 38 166406 2527 46517091
Fall 25.06 9.73 1423 165021 327674 46191944
Sleep disorder 24.95 9.73 266 166178 46529 46473089
Oromandibular dystonia 24.87 9.73 17 166427 429 46519189
On and off phenomenon 24.81 9.73 33 166411 1958 46517660
Extrapyramidal disorder 24.41 9.73 92 166352 11176 46508442
Hyperbilirubinaemia 24.30 9.73 4 166440 10434 46509184
Acute myeloid leukaemia 24.21 9.73 13 166431 15765 46503853
Neoplasm progression 24.16 9.73 36 166408 26647 46492971
Jaundice 24.15 9.73 41 166403 28804 46490814
Erythema 24.09 9.73 361 166083 142459 46377159
Transplant rejection 23.91 9.73 3 166441 9593 46510025
Urticaria 23.87 9.73 287 166157 117605 46402013
Ascites 23.86 9.73 60 166384 36524 46483094
Dizziness 23.84 9.73 1461 164983 338953 46180665
Proteinuria 23.47 9.73 15 166429 16538 46503080
Mutism 23.47 9.73 26 166418 1274 46518344
Middle insomnia 23.43 9.73 81 166363 9434 46510184
Nasopharyngitis 23.39 9.73 397 166047 153601 46366017
Fluid overload 23.35 9.73 38 166406 27147 46492471
Head titubation 23.27 9.73 19 166425 632 46518986
Generalised tonic-clonic seizure 23.20 9.73 171 166273 26951 46492667
Movement disorder 23.12 9.73 120 166324 16729 46502889
Apathy 22.57 9.73 67 166377 7201 46512417
Psychomotor retardation 22.56 9.73 41 166403 3192 46516426
Anorgasmia 22.53 9.73 18 166426 580 46519038
Rubber sensitivity 22.52 9.73 29 166415 1667 46517951
Formication 22.49 9.73 46 166398 3910 46515708
Aspiration 22.49 9.73 80 166364 9451 46510167
Metastases to liver 22.42 9.73 22 166422 19563 46500055
Hereditary angioedema 22.27 9.73 56 166388 5460 46514158
Band neutrophil percentage increased 22.04 9.73 12 166432 198 46519420
Pneumonia aspiration 21.45 9.73 189 166255 31416 46488202
Pulmonary fibrosis 21.40 9.73 24 166420 20068 46499550
Miosis 21.27 9.73 62 166382 6595 46513023
Pyrexia 21.17 9.73 1022 165422 347780 46171838
Seizure cluster 21.07 9.73 11 166433 166 46519452
Dependence 21.04 9.73 30 166414 1901 46517717
Coordination abnormal 20.97 9.73 86 166358 10863 46508755
Conversion disorder 20.94 9.73 28 166416 1670 46517948
Incontinence 20.94 9.73 80 166364 9782 46509836
Hostility 20.83 9.73 25 166419 1337 46518281
Hypokalaemia 20.72 9.73 207 166237 87817 46431801
Peritonitis 20.71 9.73 26 166418 20688 46498930
Pneumonitis 20.63 9.73 44 166400 28376 46491242
Helicobacter infection 20.61 9.73 8 166436 11728 46507890
Tension 20.59 9.73 37 166407 2855 46516763
Pulmonary hypertension 20.52 9.73 63 166381 35930 46483688
Hypertension 20.48 9.73 538 165906 195818 46323800
Weight abnormal 20.43 9.73 21 166423 944 46518674
Knee arthroplasty 20.40 9.73 33 166411 23632 46495986
Tachyphrenia 20.19 9.73 24 166420 1270 46518348
Broncholithiasis 20.16 9.73 9 166435 94 46519524
Neuropathy peripheral 20.07 9.73 217 166227 90676 46428942
Panic reaction 19.92 9.73 42 166402 3647 46515971
Urinary retention 19.89 9.73 160 166284 25901 46493717
Epistaxis 19.74 9.73 141 166303 64164 46455454
Anaphylactic shock 19.70 9.73 26 166418 20248 46499370
Wound 19.68 9.73 82 166362 42720 46476898
Rash pruritic 19.54 9.73 86 166358 44129 46475489
Exposure during pregnancy 19.48 9.73 270 166174 107942 46411676
Diverticulitis 19.43 9.73 57 166387 32982 46486636
Cerebellar atrophy 19.40 9.73 17 166427 624 46518994
Prescribed overdose 19.17 9.73 81 166363 10368 46509250
Nausea 19.16 9.73 2153 164291 685301 45834317
White blood cell count decreased 19.15 9.73 283 166161 111948 46407670
Neutropenic sepsis 19.14 9.73 10 166434 12314 46507304
Bone erosion 19.13 9.73 5 166439 9438 46510180
Hypomagnesaemia 19.12 9.73 31 166413 22179 46497439
Fibromyalgia 18.85 9.73 206 166238 36257 46483361
Drug ineffective 18.74 9.73 2124 164320 675714 45843904
Hypokinesia 18.67 9.73 85 166359 11237 46508381
Liver function test increased 18.60 9.73 33 166411 22793 46496825
Cough 18.56 9.73 653 165791 229596 46290022
Libido increased 18.56 9.73 18 166426 754 46518864
Myelocyte percentage increased 18.53 9.73 10 166434 162 46519456
Stereotypy 18.53 9.73 14 166430 415 46519203
Food craving 18.50 9.73 22 166422 1165 46518453
Intellectual disability 18.49 9.73 17 166427 665 46518953
International normalised ratio increased 18.49 9.73 95 166349 46788 46472830
Aphasia 18.45 9.73 169 166275 28398 46491220
Liver function test abnormal 18.44 9.73 94 166350 46393 46473225
Therapeutic product effect decreased 18.32 9.73 197 166247 82404 46437214
Bipolar I disorder 18.31 9.73 25 166419 1521 46518097
Suicidal behaviour 18.31 9.73 32 166412 2416 46517202
Anticonvulsant drug level below therapeutic 18.24 9.73 16 166428 588 46519030
Antidepressant drug level above therapeutic 18.22 9.73 13 166431 352 46519266
Full blood count decreased 18.20 9.73 32 166412 22179 46497439
Acute myocardial infarction 18.11 9.73 56 166388 31868 46487750
Antipsychotic drug level increased 18.01 9.73 37 166407 3155 46516463
Abdominal pain 17.94 9.73 655 165789 229376 46290242
Depersonalisation/derealisation disorder 17.89 9.73 20 166424 990 46518628
Circulatory collapse 17.86 9.73 31 166413 21593 46498025
Disseminated intravascular coagulation 17.84 9.73 25 166419 18980 46500638
Dysstasia 17.83 9.73 116 166328 17552 46502066
Osteonecrosis 17.75 9.73 41 166403 25703 46493915
Musculoskeletal pain 17.74 9.73 162 166282 69966 46449652
Drug abuser 17.68 9.73 37 166407 3196 46516422
Weight gain poor 17.55 9.73 17 166427 711 46518907
Colitis 17.52 9.73 71 166373 37276 46482342
Impulsive behaviour 17.20 9.73 24 166420 1491 46518127
Tongue discolouration 17.16 9.73 35 166409 2969 46516649
Libido decreased 16.88 9.73 32 166412 2573 46517045
Hypothermia 16.88 9.73 87 166357 12096 46507522
Screaming 16.85 9.73 36 166408 3155 46516463
Haematuria 16.78 9.73 45 166399 26813 46492805
Stoma site discharge 16.69 9.73 27 166417 1913 46517705
Change in seizure presentation 16.69 9.73 11 166433 261 46519357
Shock haemorrhagic 16.67 9.73 5 166439 8619 46510999
Cerebral haemorrhage 16.64 9.73 49 166395 28322 46491296
Drug tolerance 16.64 9.73 36 166408 3182 46516436
Hepatocellular injury 16.59 9.73 52 166392 29470 46490148
Coronary artery disease 16.57 9.73 63 166381 33689 46485929
Dysgraphia 16.51 9.73 33 166411 2759 46516859
Peripheral pulse decreased 16.44 9.73 6 166438 35 46519583
Mitral valve thickening 16.29 9.73 6 166438 36 46519582
Tic 16.20 9.73 21 166423 1215 46518403
H1N1 influenza 16.09 9.73 23 166421 1461 46518157
Urinary incontinence 16.07 9.73 164 166280 28366 46491252
Injection site pruritus 15.97 9.73 80 166364 39663 46479955
Cytopenia 15.96 9.73 4 166440 7764 46511854
Polycystic ovaries 15.82 9.73 22 166422 1362 46518256
Thrombotic microangiopathy 15.72 9.73 5 166439 8301 46511317
Myoclonus 15.58 9.73 96 166348 14256 46505362
Blood triglycerides increased 15.53 9.73 83 166361 11700 46507918
Electrocardiogram QRS complex shortened 15.48 9.73 12 166432 370 46519248
Psychiatric symptom 15.46 9.73 43 166401 4454 46515164
Lymph node calcification 15.41 9.73 9 166435 171 46519447
Oliguria 15.33 9.73 6 166438 8753 46510865
Haematemesis 15.32 9.73 52 166392 28754 46490864
Social anxiety disorder 15.28 9.73 12 166432 377 46519241
Dysphagia 15.20 9.73 372 166072 76940 46442678
Cerebrovascular accident 15.16 9.73 261 166183 100778 46418840
Metabolic acidosis 15.05 9.73 79 166365 38701 46480917
Schizoaffective disorder 15.01 9.73 22 166422 1430 46518188
Disorganised speech 15.01 9.73 17 166427 854 46518764
Hip arthroplasty 14.93 9.73 26 166418 18086 46501532
Drug ineffective for unapproved indication 14.91 9.73 105 166339 16308 46503310
Pupil fixed 14.88 9.73 24 166420 1696 46517922
Oedema 14.85 9.73 160 166284 66911 46452707
Emotional distress 14.75 9.73 171 166273 30536 46489082
Initial insomnia 14.75 9.73 42 166402 4410 46515208
Impaired healing 14.74 9.73 74 166370 36669 46482949
Cholestasis 14.68 9.73 48 166396 26845 46492773
Blood growth hormone increased 14.67 9.73 12 166432 400 46519218
Dehydration 14.62 9.73 445 165999 159095 46360523
Motor dysfunction 14.59 9.73 58 166386 7224 46512394
Femur fracture 14.57 9.73 75 166369 36922 46482696
Menstrual disorder 14.47 9.73 40 166404 4128 46515490
Attention deficit hyperactivity disorder 14.47 9.73 27 166417 2145 46517473
Sensitisation 14.45 9.73 15 166429 682 46518936
Hyperkeratosis 14.36 9.73 45 166399 4980 46514638
Rash maculo-papular 14.36 9.73 51 166393 27823 46491795
Intervertebral disc protrusion 14.35 9.73 123 166321 20282 46499336
Right ventricular systolic pressure decreased 14.33 9.73 5 166439 25 46519593
Flight of ideas 14.25 9.73 11 166433 337 46519281
Fluid retention 14.22 9.73 115 166329 50931 46468687
Ketosis-prone diabetes mellitus 14.20 9.73 4 166440 8 46519610
Diplopia 14.19 9.73 118 166326 19287 46500331
Congenital knee deformity 14.17 9.73 5 166439 26 46519592
Influenza like illness 14.16 9.73 286 166158 57284 46462334
Abulia 14.11 9.73 11 166433 342 46519276
Logorrhoea 14.09 9.73 28 166416 2331 46517287
Bradycardia neonatal 14.05 9.73 14 166430 606 46519012
Feeling of body temperature change 13.97 9.73 40 166404 4212 46515406
Bacteraemia 13.97 9.73 18 166426 14161 46505457
Tonic clonic movements 13.96 9.73 19 166425 1153 46518465
Oculocephalogyric reflex absent 13.92 9.73 3 166441 0 46519618
Periorbital swelling 13.90 9.73 20 166424 1278 46518340
Multiple organ dysfunction syndrome 13.72 9.73 118 166326 51592 46468026
Pericardial effusion 13.66 9.73 46 166398 25497 46494121
Blepharospasm 13.59 9.73 27 166417 2247 46517371
Blood prolactin increased 13.58 9.73 32 166412 2995 46516623
Coma scale abnormal 13.55 9.73 44 166400 4962 46514656
Metastases to lung 13.46 9.73 11 166433 10685 46508933
Clumsiness 13.38 9.73 23 166421 1713 46517905
Self-injurious ideation 13.38 9.73 27 166417 2273 46517345
Tubulointerstitial nephritis 13.34 9.73 20 166424 14768 46504850
Nephrogenic diabetes insipidus 13.33 9.73 15 166429 748 46518870
Periodic limb movement disorder 13.29 9.73 8 166436 161 46519457
COVID-19 13.28 9.73 29 166415 18546 46501072
Heart rate abnormal 13.27 9.73 34 166410 3353 46516265
Post-traumatic stress disorder 13.22 9.73 38 166406 4010 46515608
Oculogyric crisis 13.21 9.73 19 166425 1214 46518404
Hyperreflexia 13.17 9.73 45 166399 5209 46514409
Pruritus 13.17 9.73 718 165726 241634 46277984
Upper respiratory tract infection 13.13 9.73 154 166290 63402 46456216
Haematochezia 13.13 9.73 79 166365 37414 46482204
Inflammation 13.08 9.73 111 166333 48670 46470948
Haemoglobin urine 12.99 9.73 7 166437 113 46519505
Injection site erythema 12.93 9.73 187 166257 74240 46445378
Sebaceous gland infection 12.88 9.73 7 166437 115 46519503
Distractibility 12.88 9.73 10 166434 309 46519309
Suspected product quality issue 12.87 9.73 8 166436 171 46519447
Compulsive shopping 12.83 9.73 15 166429 780 46518838
Tinnitus 12.80 9.73 153 166291 27520 46492098
Ejection fraction 12.75 9.73 13 166431 579 46519039
Decreased interest 12.73 9.73 32 166412 3120 46516498
Tearfulness 12.73 9.73 38 166406 4097 46515521
Acute generalised exanthematous pustulosis 12.70 9.73 9 166435 9396 46510222
Prescribed underdose 12.70 9.73 80 166364 11973 46507645
Pathogen resistance 12.68 9.73 3 166441 6057 46513561
Hepatic enzyme increased 12.68 9.73 210 166234 81577 46438041
Therapeutic product effect incomplete 12.67 9.73 199 166245 77954 46441664
Parkinsonian gait 12.65 9.73 12 166432 489 46519129
Myoclonic epilepsy 12.60 9.73 16 166428 907 46518711
Victim of crime 12.56 9.73 6 166438 74 46519544
Parasomnia 12.55 9.73 11 166433 404 46519214
Peroneal nerve palsy 12.54 9.73 38 166406 4130 46515488
Anticonvulsant drug level increased 12.54 9.73 20 166424 1400 46518218
Flat affect 12.46 9.73 19 166425 1279 46518339
Gaze palsy 12.46 9.73 19 166425 1279 46518339
Drop attacks 12.46 9.73 14 166430 697 46518921
Choking 12.44 9.73 61 166383 8315 46511303
Heart rate increased 12.42 9.73 352 166092 74439 46445179
Cellulitis 12.42 9.73 176 166268 70112 46449506
Colitis ulcerative 12.42 9.73 28 166416 17704 46501914
Hyperammonaemic encephalopathy 12.41 9.73 24 166420 1958 46517660
Barotrauma 12.39 9.73 8 166436 183 46519435
Sensorimotor disorder 12.39 9.73 11 166433 411 46519207
Congenital jaw malformation 12.38 9.73 4 166440 15 46519603
Narcotic bowel syndrome 12.37 9.73 7 166437 125 46519493
Hyperammonaemia 12.36 9.73 41 166403 4675 46514943
Cerebral atrophy 12.36 9.73 41 166403 4675 46514943
Abscess 12.32 9.73 19 166425 13870 46505748
Band neutrophil count increased 12.26 9.73 10 166434 332 46519286
Sleep-related eating disorder 12.26 9.73 13 166431 606 46519012
Enuresis 12.26 9.73 24 166420 1976 46517642
Staphylococcal infection 12.20 9.73 76 166368 35695 46483923
Pulmonary haemorrhage 12.16 9.73 4 166440 6501 46513117
Stoma site pain 12.10 9.73 17 166427 1063 46518555
Colitis ischaemic 12.05 9.73 11 166433 10121 46509497
Ischaemic stroke 12.04 9.73 26 166418 16696 46502922
Urine oxalate increased 11.98 9.73 8 166436 194 46519424
Euphoric mood 11.98 9.73 38 166406 4234 46515384
Freezing phenomenon 11.96 9.73 20 166424 1457 46518161
Cholelithiasis 11.90 9.73 199 166245 38482 46481136
Specific gravity urine decreased 11.89 9.73 11 166433 434 46519184
Increased appetite 11.89 9.73 61 166383 8466 46511152
Salivary hypersecretion 11.86 9.73 50 166394 6395 46513223
Aerophagia 11.85 9.73 3 166441 3 46519615
Large intestine operation 11.85 9.73 3 166441 3 46519615
Drug detoxification 11.84 9.73 8 166436 198 46519420
Transfusion 11.83 9.73 18 166426 13213 46506405
Bronchopulmonary aspergillosis 11.76 9.73 6 166438 7490 46512128
Dysphemia 11.76 9.73 26 166418 2332 46517286
Suspected suicide 11.76 9.73 40 166404 4621 46514997
Drug screen false positive 11.65 9.73 15 166429 862 46518756
Klebsiella test positive 11.63 9.73 16 166428 981 46518637
Clostridium difficile infection 11.60 9.73 48 166396 25055 46494563
Adrenal insufficiency 11.60 9.73 18 166426 13106 46506512
Post-traumatic neck syndrome 11.58 9.73 19 166425 1362 46518256
Essential tremor 11.57 9.73 14 166430 755 46518863
Feeling jittery 11.55 9.73 73 166371 10935 46508683
Coagulopathy 11.55 9.73 31 166413 18468 46501150
Monocyte count abnormal 11.53 9.73 8 166436 207 46519411
Homicidal ideation 11.51 9.73 22 166422 1780 46517838
Arthritis 11.50 9.73 200 166244 77116 46442502
Trismus 11.49 9.73 33 166411 3482 46516136
Dairy intolerance 11.48 9.73 5 166439 49 46519569
Fractured coccyx 11.46 9.73 16 166428 994 46518624
Soft tissue haemorrhage 11.40 9.73 8 166436 211 46519407
Acute hepatic failure 11.36 9.73 22 166422 14699 46504919
Sleep terror 11.35 9.73 14 166430 770 46518848
Binge eating 11.35 9.73 10 166434 370 46519248
Feeling drunk 11.29 9.73 35 166409 3852 46515766
Lupus-like syndrome 11.27 9.73 7 166437 7837 46511781
Feelings of worthlessness 11.24 9.73 9 166435 291 46519327
Eating disorder 11.20 9.73 90 166354 14564 46505054
Cast application 11.15 9.73 4 166440 22 46519596
Metastases to bone 11.13 9.73 29 166415 17447 46502171
Concussion 11.12 9.73 52 166392 6951 46512667
Family stress 11.12 9.73 12 166432 571 46519047
Laryngeal stenosis 11.10 9.73 13 166431 677 46518941
Coagulation factor VII level decreased 11.00 9.73 4 166440 23 46519595
Hyperacusis 10.98 9.73 22 166422 1842 46517776
Gastrointestinal disorder 10.95 9.73 148 166296 59428 46460190
Stoma site hypergranulation 10.89 9.73 11 166433 484 46519134
Impulse-control disorder 10.89 9.73 13 166431 691 46518927
Sleep apnoea syndrome 10.82 9.73 124 166320 22077 46497541
Injection site pain 10.79 9.73 295 166149 106857 46412761
Anuria 10.76 9.73 15 166429 11416 46508202
Altered state of consciousness 10.76 9.73 129 166315 23219 46496399
Haemorrhage intracranial 10.73 9.73 18 166426 12706 46506912
Haematoma 10.72 9.73 68 166376 31804 46487814
Foetal growth restriction 10.69 9.73 5 166439 6562 46513056
Psychogenic seizure 10.63 9.73 17 166427 1193 46518425
Chronic papillomatous dermatitis 10.59 9.73 5 166439 60 46519558
Adverse drug reaction 10.57 9.73 104 166340 44258 46475360
Drug level above therapeutic 10.57 9.73 32 166412 3477 46516141
Reduced facial expression 10.52 9.73 17 166427 1203 46518415
Automatism 10.52 9.73 5 166439 61 46519557
Chronic kidney disease 10.52 9.73 94 166350 40777 46478841
Hypoaesthesia oral 10.46 9.73 69 166375 10490 46509128
Thrombosis 10.41 9.73 139 166305 55930 46463688
Blood ethanol increased 10.38 9.73 5 166439 63 46519555
Bone decalcification 10.34 9.73 4 166440 28 46519590
Temperature intolerance 10.31 9.73 54 166390 7553 46512065
Pancreatolithiasis 10.31 9.73 8 166436 247 46519371
Poor quality sleep 10.24 9.73 91 166353 15162 46504456
Haematotoxicity 10.22 9.73 6 166438 6927 46512691
Basal cell carcinoma 10.21 9.73 38 166406 20449 46499169
Alcohol poisoning 10.20 9.73 24 166420 2244 46517374
Nephrectomy 10.18 9.73 11 166433 524 46519094
Affective disorder 10.17 9.73 39 166405 4776 46514842
Subarachnoid haemorrhage 10.14 9.73 15 166429 11138 46508480
Hypoventilation 10.13 9.73 35 166409 4075 46515543
Hypnopompic hallucination 10.11 9.73 4 166440 30 46519588
Localised infection 10.09 9.73 47 166397 23754 46495864
Infantile spasms 10.09 9.73 8 166436 255 46519363
Breast cancer metastatic 10.08 9.73 21 166423 13657 46505961
Myelodysplastic syndrome 10.06 9.73 26 166418 15685 46503933
Obsessive-compulsive symptom 10.00 9.73 4 166440 31 46519587
Somnambulism 9.99 9.73 40 166404 4997 46514621
Body height increased 9.97 9.73 5 166439 69 46519549
Respiratory rate decreased 9.97 9.73 29 166415 3081 46516537
Therapeutic product ineffective 9.96 9.73 15 166429 999 46518619
Oral pain 9.91 9.73 50 166394 24747 46494871
Homeless 9.89 9.73 4 166440 32 46519586
Toxic leukoencephalopathy 9.88 9.73 11 166433 542 46519076
Soliloquy 9.86 9.73 7 166437 188 46519430
Cushingoid 9.86 9.73 5 166439 6261 46513357
Myelocyte count increased 9.83 9.73 9 166435 350 46519268
Epstein-Barr virus infection 9.82 9.73 6 166438 6778 46512840
Arthritis infective 9.82 9.73 3 166441 5110 46514508
Electrocardiogram QRS complex prolonged 9.81 9.73 42 166402 5407 46514211
Narcolepsy 9.79 9.73 16 166428 1143 46518475
Muscle contractions involuntary 9.79 9.73 22 166422 1996 46517622
Alcohol abuse 9.78 9.73 23 166421 2149 46517469
Retinal detachment 9.78 9.73 3 166441 5097 46514521
Hospitalisation 9.74 9.73 163 166281 63222 46456396
Cytokine release syndrome 9.74 9.73 5 166439 6218 46513400

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 829.36 10.36 1116 87895 80956 29782511
Completed suicide 709.09 10.36 1148 87863 98344 29765123
Toxicity to various agents 520.83 10.36 1421 87590 175762 29687705
Depression 467.28 10.36 907 88104 89530 29773937
Sopor 287.67 10.36 248 88763 10743 29852724
Somnolence 282.27 10.36 775 88236 95988 29767479
Anxiety 266.27 10.36 724 88287 89147 29774320
Overdose 256.44 10.36 686 88325 83651 29779816
Seizure 244.01 10.36 744 88267 97731 29765736
Intentional overdose 221.10 10.36 422 88589 41059 29822408
Respiratory arrest 220.58 10.36 347 88664 28911 29834556
Neuroleptic malignant syndrome 205.74 10.36 248 88763 16047 29847420
Suicide attempt 203.83 10.36 380 88631 36317 29827150
Sedation 176.10 10.36 230 88781 16143 29847324
Agitation 175.59 10.36 451 88560 53622 29809845
Suicidal ideation 170.21 10.36 349 88662 35765 29827702
Aggression 160.36 10.36 345 88666 36562 29826905
Intentional self-injury 151.64 10.36 194 88817 13338 29850129
Cardio-respiratory arrest 147.42 10.36 439 88572 56867 29806600
Intentional product misuse 139.21 10.36 314 88697 34353 29829114
Coma 138.19 10.36 344 88667 40105 29823362
Anaemia 137.18 10.36 256 88755 207736 29655731
Febrile neutropenia 135.72 10.36 74 88937 106619 29756848
Psychotic disorder 129.82 10.36 231 88780 21284 29842183
Drug withdrawal syndrome 127.73 10.36 219 88792 19590 29843877
Acute kidney injury 125.02 10.36 408 88603 273434 29590033
Drug interaction 122.85 10.36 1012 87999 198556 29664911
Drug dependence 118.79 10.36 221 88790 21074 29842393
Abnormal behaviour 116.45 10.36 244 88767 25379 29838088
Status epilepticus 113.59 10.36 152 88859 10920 29852547
Poisoning 104.35 10.36 148 88863 11234 29852233
Dyspnoea 103.76 10.36 575 88436 332720 29530747
Substance abuse 103.66 10.36 116 88895 6924 29856543
Insomnia 102.93 10.36 548 88463 92788 29770679
Interstitial lung disease 102.88 10.36 26 88985 60171 29803296
Dyskinesia 98.14 10.36 207 88804 21627 29841840
Panic attack 94.96 10.36 123 88888 8558 29854909
Cardiac arrest 91.59 10.36 529 88482 92321 29771146
Speech disorder 90.66 10.36 215 88796 24297 29839170
Depressed level of consciousness 88.18 10.36 282 88729 37940 29825527
Parkinsonism 87.46 10.36 108 88903 7161 29856306
Thrombocytopenia 84.75 10.36 175 88836 136869 29726598
Pancytopenia 84.40 10.36 77 88934 84975 29778492
Diarrhoea 81.24 10.36 621 88390 333482 29529985
Granulocytopenia 80.60 10.36 96 88915 6130 29857337
Sepsis 77.62 10.36 203 88808 146192 29717275
Malignant neoplasm progression 77.16 10.36 61 88950 72226 29791241
Ataxia 76.89 10.36 129 88882 11333 29852134
Hallucination 75.18 10.36 317 88694 48742 29814725
Paranoia 74.20 10.36 119 88892 10069 29853398
Dystonia 74.14 10.36 116 88895 9611 29853856
Drug withdrawal convulsions 74.10 10.36 45 88966 1114 29862353
Miosis 74.08 10.36 103 88908 7673 29855794
Renal failure 71.31 10.36 175 88836 128791 29734676
Serotonin syndrome 69.51 10.36 160 88851 17731 29845736
Akathisia 68.27 10.36 86 88925 5818 29857649
Cardiac failure 66.85 10.36 90 88921 83328 29780139
Pneumonia 66.69 10.36 654 88357 333652 29529815
Myocardial infarction 65.96 10.36 175 88836 125450 29738017
Salivary hypersecretion 65.86 10.36 96 88915 7470 29855997
Restlessness 65.68 10.36 181 88830 22418 29841049
Thinking abnormal 65.65 10.36 80 88931 5231 29858236
Tremor 64.53 10.36 414 88597 74949 29788518
Muscle rigidity 64.24 10.36 112 88899 10149 29853318
Rash 62.86 10.36 325 88686 191564 29671903
Hallucination, auditory 60.19 10.36 106 88905 9683 29853784
Hyperkalaemia 59.47 10.36 65 88946 65945 29797522
Epilepsy 59.07 10.36 162 88849 20007 29843460
Psychomotor hyperactivity 58.45 10.36 95 88916 8129 29855338
Anger 57.79 10.36 112 88899 11008 29852459
Memory impairment 56.78 10.36 240 88771 36934 29826533
Disease progression 56.41 10.36 94 88917 79780 29783687
Generalised tonic-clonic seizure 55.25 10.36 155 88856 19396 29844071
Respiratory depression 55.13 10.36 112 88899 11391 29852076
Irritability 54.92 10.36 172 88839 22878 29840589
Bradykinesia 54.15 10.36 57 88954 3173 29860294
Pneumonia aspiration 53.94 10.36 239 88772 37541 29825926
Drug use disorder 53.89 10.36 57 88954 3191 29860276
Atrial fibrillation 53.48 10.36 155 88856 107969 29755498
Tardive dyskinesia 52.75 10.36 70 88941 4987 29858480
Pyrexia 52.59 10.36 591 88420 293898 29569569
Delusion 51.94 10.36 112 88899 11877 29851590
Platelet count decreased 51.86 10.36 153 88858 105976 29757491
Gastrointestinal haemorrhage 51.16 10.36 107 88904 83339 29780128
Plasma cell myeloma 51.14 10.36 50 88961 53412 29810055
Neutropenia 50.84 10.36 203 88808 128337 29735130
Housebound 50.82 10.36 20 88991 181 29863286
Disturbance in attention 50.77 10.36 163 88848 21966 29841501
Psychiatric decompensation 50.09 10.36 37 88974 1278 29862189
Gait disturbance 50.07 10.36 387 88624 74390 29789077
Nervousness 49.79 10.36 109 88902 11679 29851788
Pleural effusion 49.71 10.36 90 88921 73976 29789491
Renal impairment 49.08 10.36 111 88900 84073 29779394
Cardiac failure congestive 48.64 10.36 112 88899 84295 29779172
Confusional state 48.58 10.36 613 88398 134221 29729246
Cognitive disorder 47.71 10.36 167 88844 23523 29839944
Behaviour disorder 46.69 10.36 46 88965 2366 29861101
Mental disorder 46.54 10.36 115 88896 13334 29850133
Loss of personal independence in daily activities 46.16 10.36 155 88856 21380 29842087
Stomatitis 45.71 10.36 27 88984 37252 29826215
Cerebrovascular accident 44.76 10.36 115 88896 83362 29780105
Depression suicidal 44.38 10.36 34 88977 1242 29862225
Disorientation 44.27 10.36 198 88813 31220 29832247
Hyperprolactinaemia 44.00 10.36 33 88978 1167 29862300
Haemoglobin decreased 43.97 10.36 182 88829 113916 29749551
Catatonia 43.20 10.36 59 88952 4321 29859146
Device interaction 41.99 10.36 22 88989 406 29863061
Rheumatoid arthritis 41.19 10.36 37 88974 41160 29822307
Withdrawal syndrome 40.85 10.36 98 88913 11152 29852315
Psychomotor skills impaired 40.67 10.36 39 88972 1940 29861527
Dysarthria 40.62 10.36 189 88822 30301 29833166
General physical health deterioration 40.03 10.36 157 88854 99787 29763680
Drug abuser 40.00 10.36 57 88954 4344 29859123
Drooling 39.99 10.36 47 88964 2958 29860509
Tearfulness 39.70 10.36 35 88976 1561 29861906
Obsessive-compulsive disorder 39.67 10.36 55 88956 4086 29859381
Acute myocardial infarction 39.54 10.36 60 88951 52879 29810588
Disinhibition 39.15 10.36 38 88973 1919 29861548
Prescribed overdose 38.26 10.36 81 88930 8480 29854987
Joint swelling 38.25 10.36 50 88961 46896 29816571
Medication error 38.12 10.36 143 88868 20829 29842638
Agoraphobia 37.63 10.36 17 88994 223 29863244
Infusion related reaction 37.57 10.36 39 88972 40525 29822942
Altered state of consciousness 37.19 10.36 137 88874 19782 29843685
Mental impairment 37.17 10.36 84 88927 9193 29854274
Bradyphrenia 37.07 10.36 52 88959 3905 29859562
Mania 36.81 10.36 83 88928 9071 29854396
Angioedema 36.69 10.36 29 88982 34355 29829112
On and off phenomenon 36.47 10.36 44 88967 2847 29860620
Psychomotor retardation 36.40 10.36 40 88971 2339 29861128
Blood creatinine increased 36.29 10.36 144 88867 91231 29772236
Postmortem blood drug level increased 35.64 10.36 14 88997 126 29863341
Postmortem blood drug level abnormal 35.34 10.36 16 88995 211 29863256
Lactic acidosis 35.01 10.36 25 88986 31188 29832279
Infection 34.99 10.36 117 88894 77957 29785510
Oedema peripheral 34.72 10.36 179 88832 105653 29757814
Movement disorder 34.72 10.36 85 88926 9798 29853669
Bone marrow failure 34.54 10.36 23 88988 29762 29833705
Cough 34.04 10.36 226 88785 125416 29738051
Cytomegalovirus infection 33.77 10.36 14 88997 23660 29839807
Cerebral haemorrhage 33.53 10.36 29 88982 32858 29830609
Loss of consciousness 33.46 10.36 372 88639 79003 29784464
Blood creatine phosphokinase increased 33.36 10.36 234 88777 43614 29819853
Drug ineffective 33.24 10.36 1280 87731 339107 29524360
Unresponsive to stimuli 33.18 10.36 161 88850 26258 29837209
Screaming 32.73 10.36 29 88982 1302 29862165
Toxicologic test abnormal 32.16 10.36 21 88990 592 29862875
Mydriasis 32.07 10.36 62 88949 6081 29857386
Abnormal dreams 31.98 10.36 73 88938 8042 29855425
Fall 31.95 10.36 736 88275 181136 29682331
Drug hypersensitivity 31.87 10.36 101 88910 68418 29795049
Restless legs syndrome 31.86 10.36 66 88945 6806 29856661
Ascites 31.65 10.36 36 88975 35885 29827582
Myoclonus 31.39 10.36 99 88912 13213 29850254
Psychogenic seizure 31.24 10.36 16 88995 281 29863186
Coronary artery disease 31.08 10.36 63 88948 49649 29813818
Drug diversion 30.96 10.36 24 88987 892 29862575
Schizophrenia 30.92 10.36 77 88934 8971 29854496
Poor quality sleep 30.63 10.36 67 88944 7174 29856293
Feeling of despair 30.42 10.36 24 88987 916 29862551
Myelodysplastic syndrome 30.39 10.36 9 89002 18769 29844698
Choreoathetosis 30.35 10.36 24 88987 919 29862548
Decreased appetite 30.28 10.36 292 88719 149618 29713849
Melaena 30.25 10.36 31 88980 32406 29831061
Hallucination, visual 30.23 10.36 111 88900 16002 29847465
Urticaria 30.21 10.36 74 88937 54532 29808935
Nausea 30.16 10.36 663 88348 296294 29567173
Septic shock 30.11 10.36 93 88918 63514 29799953
Pneumocystis jirovecii pneumonia 30.00 10.36 7 89004 17113 29846354
Product substitution issue 29.77 10.36 81 88930 9954 29853513
Crying 29.76 10.36 57 88954 5552 29857915
Dyspnoea exertional 29.62 10.36 37 88974 35393 29828074
Illness anxiety disorder 29.58 10.36 13 88998 159 29863308
Vessel puncture site erythema 28.93 10.36 6 89005 0 29863467
Myoclonic epilepsy 28.70 10.36 22 88989 804 29862663
Contraindicated product administered 28.37 10.36 8 89003 17223 29846244
Generalised anxiety disorder 28.35 10.36 20 88991 642 29862825
Tension 28.15 10.36 29 88982 1574 29861893
Electroencephalogram abnormal 28.12 10.36 35 88976 2339 29861128
Multiple-drug resistance 28.08 10.36 39 88972 2902 29860565
Panic disorder 27.71 10.36 25 88986 1150 29862317
Drug screen positive 27.45 10.36 48 88963 4359 29859108
Sleep apnoea syndrome 27.43 10.36 111 88900 16746 29846721
Middle insomnia 27.41 10.36 56 88955 5717 29857750
Pruritus 27.04 10.36 223 88788 117981 29745486
Haematuria 27.03 10.36 58 88953 44776 29818691
Dystonic tremor 26.90 10.36 11 89000 111 29863356
Mucosal inflammation 26.39 10.36 31 88980 30463 29833004
Affect lability 26.37 10.36 41 88970 3377 29860090
Accidental overdose 26.36 10.36 116 88895 18159 29845308
Gastrointestinal hypermotility 26.23 10.36 11 89000 119 29863348
Bronchopulmonary aspergillosis 26.02 10.36 3 89008 12281 29851186
Bipolar disorder 25.99 10.36 43 88968 3733 29859734
Cerebral infarction 25.99 10.36 24 88987 26349 29837118
Blunted affect 25.98 10.36 14 88997 274 29863193
Dysphoria 25.97 10.36 32 88979 2116 29861351
Tachyphrenia 25.95 10.36 23 88988 1033 29862434
Drug tolerance 25.81 10.36 32 88979 2130 29861337
Depressive symptom 25.76 10.36 28 88983 1617 29861850
Proteinuria 25.66 10.36 8 89003 16137 29847330
Torticollis 25.60 10.36 23 88988 1052 29862415
Talipes 25.34 10.36 28 88983 1647 29861820
Postictal paralysis 25.14 10.36 11 89000 133 29863334
Blood creatine phosphokinase 24.99 10.36 9 89002 62 29863405
Erythema 24.83 10.36 132 88879 77319 29786148
Anaphylactic reaction 24.69 10.36 28 88983 27954 29835513
Weight increased 24.59 10.36 335 88676 74578 29788889
Stoma site discharge 24.30 10.36 26 88985 1475 29861992
Colitis 23.92 10.36 34 88977 30786 29832681
Bradypnoea 23.85 10.36 29 88982 1892 29861575
Drug level above therapeutic 23.73 10.36 36 88975 2903 29860564
Purpura fulminans 23.46 10.36 10 89001 113 29863354
Treatment failure 23.38 10.36 42 88969 34637 29828830
Multiple organ dysfunction syndrome 23.37 10.36 103 88908 63384 29800083
Atonic seizures 23.27 10.36 11 89000 161 29863306
Injection site exfoliation 22.71 10.36 6 89005 11 29863456
Withdrawal arrhythmia 22.57 10.36 7 89004 28 29863439
Hypotonia 22.56 10.36 58 88953 6890 29856577
Nightmare 22.49 10.36 83 88928 11993 29851474
International normalised ratio increased 22.45 10.36 70 88941 47669 29815798
Personality disorder 22.31 10.36 22 88989 1133 29862334
Amnesia 22.27 10.36 136 88875 24185 29839282
Acute myeloid leukaemia 22.13 10.36 13 88998 17993 29845474
Feeling abnormal 22.11 10.36 262 88749 56494 29806973
Injection site dryness 22.05 10.36 6 89005 13 29863454
Pulmonary fibrosis 21.71 10.36 10 89001 15880 29847587
Oedema 21.69 10.36 61 88950 42932 29820535
Gambling disorder 21.59 10.36 27 88984 1813 29861654
Drug screen negative 21.52 10.36 12 88999 252 29863215
Physical assault 21.40 10.36 22 88989 1191 29862276
Neutropenic sepsis 21.36 10.36 4 89007 11405 29852062
Ehlers-Danlos syndrome 21.31 10.36 7 89004 35 29863432
Balance disorder 21.23 10.36 183 88828 36310 29827157
Congenital melanocytic naevus 21.18 10.36 6 89005 16 29863451
Antidepressant drug level increased 21.17 10.36 9 89002 101 29863366
Post-traumatic stress disorder 21.06 10.36 25 88986 1590 29861877
Blood bilirubin increased 20.77 10.36 49 88962 36587 29826880
Device dislocation 20.65 10.36 46 88965 4985 29858482
Cerebral artery thrombosis 20.61 10.36 15 88996 506 29862961
Neuropathy peripheral 20.48 10.36 124 88887 70351 29793116
Dysmetria 20.37 10.36 13 88998 352 29863115
Apathy 20.21 10.36 52 88959 6180 29857287
Arthralgia 20.20 10.36 283 88728 135508 29727959
Hypertonia 20.19 10.36 42 88969 4343 29859124
Depressed mood 20.11 10.36 102 88909 16927 29846540
Hyperammonaemia 19.95 10.36 48 88963 5472 29857995
Multiple sclerosis 19.93 10.36 57 88954 7210 29856257
Persecutory delusion 19.87 10.36 28 88983 2112 29861355
Spasmodic dysphonia 19.81 10.36 8 89003 78 29863389
Coordination abnormal 19.74 10.36 57 88954 7248 29856219
Hepatotoxicity 19.74 10.36 15 88996 18130 29845337
Electrocardiogram QRS complex prolonged 19.73 10.36 41 88970 4236 29859231
Brain scan abnormal 19.70 10.36 16 88995 637 29862830
Multiple sclerosis relapse 19.68 10.36 74 88937 10788 29852679
Heat stroke 19.52 10.36 18 88993 852 29862615
Osteonecrosis of jaw 19.49 10.36 16 88995 18602 29844865
Drug level decreased 19.41 10.36 49 88962 5756 29857711
Bruxism 19.33 10.36 22 88989 1337 29862130
Haematemesis 19.27 10.36 30 88981 26173 29837294
Tubulointerstitial nephritis 19.20 10.36 15 88996 17876 29845591
Reduced facial expression 19.19 10.36 17 88994 763 29862704
Cogwheel rigidity 18.96 10.36 20 88991 1116 29862351
Terminal insomnia 18.85 10.36 13 88998 402 29863065
Hypomania 18.73 10.36 28 88983 2228 29861239
Hypokalaemia 18.73 10.36 81 88930 50111 29813356
Extrapyramidal disorder 18.68 10.36 72 88939 10621 29852846
Blood prolactin increased 18.52 10.36 22 88989 1400 29862067
Partial seizures 18.43 10.36 37 88974 3730 29859737
Exposure via ingestion 18.33 10.36 30 88981 2581 29860886
Poverty of speech 18.28 10.36 10 89001 202 29863265
Aspergillus infection 18.25 10.36 4 89007 10210 29853257
Homicidal ideation 18.25 10.36 29 88982 2434 29861033
Laboratory test abnormal 18.24 10.36 15 88996 17427 29846040
Depersonalisation/derealisation disorder 18.23 10.36 14 88997 513 29862954
Drug intolerance 18.21 10.36 71 88940 45220 29818247
Bacteraemia 18.06 10.36 12 88999 15548 29847919
Major depression 17.91 10.36 38 88973 3984 29859483
Dehydration 17.83 10.36 259 88752 123280 29740187
Victim of crime 17.77 10.36 11 89000 282 29863185
Stereotypy 17.75 10.36 14 88997 534 29862933
Hepatic cirrhosis 17.69 10.36 13 88998 15986 29847481
Haematochezia 17.68 10.36 48 88963 34174 29829293
Developmental regression 17.65 10.36 6 89005 34 29863433
Electrocardiogram QT shortened 17.63 10.36 9 89002 157 29863310
Asthenia 17.58 10.36 512 88499 220778 29642689
Pulmonary embolism 17.58 10.36 148 88863 77987 29785480
Sleep-related eating disorder 17.53 10.36 11 89000 289 29863178
Psoriasis 17.49 10.36 66 88945 42440 29821027
Freezing phenomenon 17.48 10.36 25 88986 1911 29861556
Haemorrhage 17.42 10.36 74 88937 46005 29817462
Nephropathy toxic 17.40 10.36 5 89006 10634 29852833
Frustration tolerance decreased 17.15 10.36 25 88986 1945 29861522
Angina pectoris 17.12 10.36 39 88972 29479 29833988
Renal hypertension 17.08 10.36 9 89002 168 29863299
Obsessive-compulsive personality disorder 17.04 10.36 9 89002 169 29863298
Myelocyte count increased 17.00 10.36 7 89004 72 29863395
Lennox-Gastaut syndrome 16.96 10.36 6 89005 39 29863428
Language disorder 16.90 10.36 20 88991 1268 29862199
Panic reaction 16.89 10.36 21 88990 1402 29862065
Priapism 16.88 10.36 41 88970 4702 29858765
Hyperthermia 16.83 10.36 67 88944 10032 29853435
Physical abuse 16.75 10.36 5 89006 17 29863450
Bipolar I disorder 16.73 10.36 16 88995 793 29862674
Posture abnormal 16.73 10.36 24 88987 1840 29861627
Hypertension 16.63 10.36 257 88754 121097 29742370
Basal cell carcinoma 16.58 10.36 14 88997 16054 29847413
Palmar-plantar erythrodysaesthesia syndrome 16.55 10.36 12 88999 14858 29848609
Muscle spasticity 16.53 10.36 43 88968 5145 29858322
Brain malformation 16.51 10.36 7 89004 78 29863389
Thrombosis 16.47 10.36 67 88944 42164 29821303
Posterior reversible encephalopathy syndrome 16.41 10.36 3 89008 8704 29854763
Sexual dysfunction 16.39 10.36 47 88964 5954 29857513
Encephalitis toxic 16.34 10.36 8 89003 127 29863340
Sedation complication 16.32 10.36 16 88995 818 29862649
Peritonitis 16.17 10.36 24 88987 21351 29842116
Thrombotic microangiopathy 16.16 10.36 3 89008 8607 29854860
Allodynia 15.98 10.36 14 88997 619 29862848
Anaphylactic shock 15.96 10.36 11 89000 13982 29849485
HIV peripheral neuropathy 15.89 10.36 6 89005 48 29863419
Liver disorder 15.87 10.36 41 88970 29681 29833786
Galactorrhoea 15.84 10.36 11 89000 344 29863123
Impulsive behaviour 15.76 10.36 24 88987 1941 29861526
Brain injury 15.68 10.36 44 88967 5504 29857963
Type 2 diabetes mellitus 15.67 10.36 81 88930 13541 29849926
Gout 15.64 10.36 17 88994 17298 29846169
Asterixis 15.62 10.36 19 88992 1240 29862227
Myocarditis 15.56 10.36 65 88946 9946 29853521
Epistaxis 15.51 10.36 93 88918 52888 29810579
Shock haemorrhagic 15.48 10.36 5 89006 9860 29853607
Upper gastrointestinal haemorrhage 15.46 10.36 26 88985 22002 29841465
Muscle contracture 15.43 10.36 18 88993 1124 29862343
Vomiting 15.42 10.36 517 88494 219301 29644166
Stress 15.39 10.36 108 88903 20127 29843340
Increased appetite 15.34 10.36 44 88967 5573 29857894
Deep vein thrombosis 15.29 10.36 111 88900 60390 29803077
Phaeochromocytoma malignant 15.28 10.36 6 89005 54 29863413
Parkinsonian gait 15.18 10.36 12 88999 459 29863008
Arthritis 15.18 10.36 31 88980 24370 29839097
Anhidrosis 15.15 10.36 7 89004 97 29863370
Infantile spasms 15.10 10.36 10 89001 289 29863178
Somnambulism 15.05 10.36 31 88980 3183 29860284
Stoma site erythema 15.02 10.36 17 88994 1027 29862440
Nasal septum deviation 15.00 10.36 16 88995 904 29862563
Chills 14.96 10.36 140 88871 72198 29791269
Hypersomnia 14.96 10.36 70 88941 11246 29852221
Cluster headache 14.95 10.36 13 88998 569 29862898
Feeling guilty 14.95 10.36 10 89001 294 29863173
Blood bicarbonate decreased 14.77 10.36 26 88985 2373 29861094
Logorrhoea 14.72 10.36 24 88987 2058 29861409
Red cell distribution width decreased 14.56 10.36 8 89003 163 29863304
Staphylococcal sepsis 14.56 10.36 5 89006 9486 29853981
Feeling jittery 14.49 10.36 34 88977 3814 29859653
Graft versus host disease 14.48 10.36 6 89005 10144 29853323
Anal spasm 14.47 10.36 3 89008 0 29863467
Eustachian tube disorder 14.47 10.36 3 89008 0 29863467
Stoma site extravasation 14.43 10.36 8 89003 166 29863301
Dependence 14.40 10.36 18 88993 1208 29862259
Mental status changes 14.36 10.36 171 88840 36908 29826559
Libido increased 14.34 10.36 15 88996 829 29862638
Antipsychotic drug level increased 14.20 10.36 30 88981 3136 29860331
Wrong schedule 14.14 10.36 7 89004 114 29863353
Withdrawal hypertension 14.14 10.36 6 89005 67 29863400
Hyperosmolar state 14.10 10.36 11 89000 413 29863054
Postoperative respiratory failure 14.06 10.36 6 89005 68 29863399
Cholangitis 14.05 10.36 3 89008 7799 29855668
Dopamine dysregulation syndrome 13.98 10.36 12 88999 516 29862951
Cytokine release syndrome 13.96 10.36 6 89005 9927 29853540
Tooth injury 13.96 10.36 14 88997 736 29862731
Myalgia 13.94 10.36 153 88858 76514 29786953
Intensive care unit acquired weakness 13.93 10.36 15 88996 857 29862610
Ejaculation disorder 13.91 10.36 16 88995 984 29862483
Locomotive syndrome 13.78 10.36 4 89007 12 29863455
Clonic convulsion 13.73 10.36 12 88999 529 29862938
Cholestasis 13.65 10.36 34 88977 24916 29838551
Self esteem decreased 13.63 10.36 12 88999 534 29862933
Peripheral swelling 13.59 10.36 116 88895 60958 29802509
Accommodation disorder 13.58 10.36 8 89003 187 29863280
Hostility 13.55 10.36 15 88996 884 29862583
Chronic kidney disease 13.55 10.36 62 88949 37776 29825691
Product complaint 13.52 10.36 43 88968 5763 29857704
Drug ineffective for unapproved indication 13.44 10.36 66 88945 10814 29852653
Accidental death 13.41 10.36 23 88988 2056 29861411
Erectile dysfunction 13.41 10.36 96 88915 18006 29845461
Sleep disorder 13.33 10.36 121 88890 24358 29839109
Central pain syndrome 13.32 10.36 7 89004 130 29863337
Death 13.32 10.36 899 88112 356384 29507083
Herpes zoster 13.31 10.36 45 88966 29898 29833569
Haemorrhage intracranial 13.31 10.36 15 88996 15017 29848450
Hyperchloraemia 13.26 10.36 11 89000 451 29863016
Urinary incontinence 13.23 10.36 91 88920 16849 29846618
Gallbladder polyp 13.20 10.36 9 89002 273 29863194
Blepharospasm 13.19 10.36 15 88996 911 29862556
Hypomagnesaemia 13.19 10.36 18 88993 16580 29846887
Lethargy 13.07 10.36 177 88834 39342 29824125
Dementia with Lewy bodies 13.01 10.36 12 88999 568 29862899
Learning disorder 12.98 10.36 11 89000 465 29863002
Inappropriate affect 12.98 10.36 12 88999 570 29862897
Bipolar II disorder 12.90 10.36 4 89007 16 29863451
Psychiatric symptom 12.88 10.36 30 88981 3349 29860118
Tuberculosis 12.84 10.36 4 89007 8073 29855394
Drug level increased 12.83 10.36 96 88915 18258 29845209
Libido decreased 12.70 10.36 36 88975 4530 29858937
Bulbar palsy 12.66 10.36 8 89003 213 29863254
Syncope 12.59 10.36 177 88834 84726 29778741
Purpura 12.53 10.36 7 89004 9960 29853507
Intelligence test abnormal 12.52 10.36 4 89007 18 29863449
Areflexia 12.47 10.36 26 88985 2693 29860774
Dysstasia 12.46 10.36 63 88948 10442 29853025
Accidental poisoning 12.43 10.36 11 89000 493 29862974
Pseudodementia 12.39 10.36 3 89008 3 29863464
Hypothermia neonatal 12.39 10.36 6 89005 93 29863374
Somatic symptom disorder 12.36 10.36 11 89000 497 29862970
Infective pulmonary exacerbation of cystic fibrosis 12.34 10.36 5 89006 8567 29854900
Dementia 12.25 10.36 71 88940 12390 29851077
Hyperhidrosis 12.21 10.36 273 88738 66817 29796650
Substance dependence 12.14 10.36 10 89001 406 29863061
Stupor 12.12 10.36 27 88984 2926 29860541
Autonomic nervous system imbalance 12.11 10.36 24 88987 2397 29861070
Neurosis 12.10 10.36 7 89004 158 29863309
Agitated depression 12.02 10.36 8 89003 233 29863234
Glossopharyngeal nerve disorder 12.02 10.36 4 89007 21 29863446
Squamous cell carcinoma of skin 12 10.36 6 89005 9089 29854378
Neoplasm progression 11.99 10.36 22 88989 18001 29845466
Haematuria traumatic 11.95 10.36 7 89004 162 29863305
Muscle twitching 11.94 10.36 52 88959 8103 29855364
Change in seizure presentation 11.93 10.36 5 89006 54 29863413
Feeling drunk 11.91 10.36 19 88992 1600 29861867
Post concussion syndrome 11.85 10.36 5 89006 55 29863412
Senile dementia 11.85 10.36 5 89006 55 29863412
Atrial flutter 11.84 10.36 15 88996 14266 29849201
Jaundice 11.77 10.36 53 88958 32433 29831034
Cerebral arteriosclerosis 11.69 10.36 10 89001 428 29863039
Mumps 11.68 10.36 6 89005 106 29863361
Clostridium difficile infection 11.67 10.36 18 88993 15765 29847702
Helplessness 11.61 10.36 5 89006 58 29863409
Cytopenia 11.58 10.36 5 89006 8251 29855216
Rapid eye movement sleep behaviour disorder 11.58 10.36 6 89005 108 29863359
Diet refusal 11.58 10.36 9 89002 336 29863131
Social avoidant behaviour 11.55 10.36 26 88985 2837 29860630
Obsessive thoughts 11.53 10.36 12 88999 659 29862808
Pneumothorax 11.47 10.36 19 88992 16174 29847293
Delirium 11.46 10.36 177 88834 40454 29823013
Defect conduction intraventricular 11.39 10.36 7 89004 177 29863290
Prostate cancer 11.35 10.36 35 88976 23922 29839545
Therapy non-responder 11.31 10.36 47 88964 29406 29834061
Dissociative identity disorder 11.30 10.36 4 89007 26 29863441
Tumour lysis syndrome 11.25 10.36 13 88998 12872 29850595
Oropharyngeal pain 11.24 10.36 45 88966 28451 29835016
Communication disorder 11.24 10.36 22 88989 2178 29861289
Chondrocalcinosis 11.23 10.36 8 89003 261 29863206
Ventricular hypoplasia 11.18 10.36 5 89006 64 29863403
Renal injury 11.17 10.36 11 89000 11718 29851749
Pulmonary hypertension 11.16 10.36 25 88986 19011 29844456
Brain oedema 11.14 10.36 69 88942 12329 29851138
Therapeutic response unexpected 10.99 10.36 54 88957 8849 29854618
Pseudomonas infection 10.98 10.36 9 89002 10473 29852994
Adrenal insufficiency 10.94 10.36 9 89002 10454 29853013
Rectal haemorrhage 10.94 10.36 60 88951 34879 29828588
COVID-19 10.88 10.36 23 88988 17855 29845612
Irregular sleep phase 10.84 10.36 5 89006 69 29863398
Blood osmolarity decreased 10.83 10.36 11 89000 587 29862880
Fluid retention 10.82 10.36 38 88973 24960 29838507
Cellulitis 10.80 10.36 88 88923 46696 29816771
Disseminated intravascular coagulation 10.78 10.36 32 88979 22139 29841328
Haemophagocytic lymphohistiocytosis 10.77 10.36 8 89003 9783 29853684
Somatic delusion 10.76 10.36 6 89005 126 29863341
Eye movement disorder 10.76 10.36 31 88980 3937 29859530
Myositis 10.76 10.36 9 89002 10368 29853099
Swelling face 10.76 10.36 30 88981 21174 29842293
Malaise 10.70 10.36 397 88614 166565 29696902
Diffuse large B-cell lymphoma 10.61 10.36 5 89006 7836 29855631
Stoma site inflammation 10.59 10.36 11 89000 603 29862864
Clonus 10.54 10.36 23 88988 2458 29861009
Hallucinations, mixed 10.53 10.36 23 88988 2460 29861007
Acute coronary syndrome 10.50 10.36 15 88996 13558 29849909
Intestinal dilatation 10.47 10.36 15 88996 1149 29862318
Anticonvulsant drug level decreased 10.46 10.36 14 88997 1005 29862462
Peritonitis bacterial 10.46 10.36 11 89000 11367 29852100
Fluid overload 10.45 10.36 26 88985 19066 29844401
Ammonia increased 10.42 10.36 32 88979 4209 29859258
Metamyelocyte count increased 10.41 10.36 5 89006 76 29863391
Face oedema 10.38 10.36 11 89000 11323 29852144

Pharmacologic Action:

SourceCodeDescription
ATC N03AE01 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Benzodiazepine derivatives
FDA CS M0002356 Benzodiazepines
FDA EPC N0000175694 Benzodiazepine
CHEBI has role CHEBI:35474 minor tranquilisers
CHEBI has role CHEBI:35623 antiepileptic
CHEBI has role CHEBI:50268 gaba modulators
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Myoclonic seizure indication 37356005
Atonic seizure indication 42365007
Absence seizure indication 79631006
Lennox-Gastaut syndrome indication 230418006
Panic disorder indication 371631005 DOID:594
Akathisia off-label use 285145004
Manic Bipolar Disorder Adjunct Treatment off-label use
Suicidal thoughts contraindication 6471006
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Hepatic failure contraindication 59927004
Substance abuse contraindication 66214007
Sleep apnea contraindication 73430006 DOID:0050847
Decreased respiratory function contraindication 80954004
Open-angle glaucoma contraindication 84494001 DOID:1067
Kidney disease contraindication 90708001 DOID:557
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Syncope contraindication 271594007
Pregnancy, function contraindication 289908002
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.65 acidic
pKa2 1.65 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 8.07 WOMBAT-PK CHEMBL
GABA-A receptor; anion channel Ion channel Ki 9.07 CHEMBL
GABA-A receptor; anion channel Ion channel IC50 8.77 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 9.07 CHEMBL

External reference:

IDSource
4017791 VUID
N0000146152 NUI
D00280 KEGG_DRUG
4017791 VANDF
C0009011 UMLSCUI
CHEBI:3756 CHEBI
CHEMBL452 ChEMBL_ID
DB01068 DRUGBANK_ID
D002998 MESH_DESCRIPTOR_UI
2802 PUBCHEM_CID
6963 IUPHAR_LIGAND_ID
2765 INN_ID
5PE9FDE8GB UNII
202585 RXNORM
1345 MMSL
377 MMSL
4477 MMSL
d00197 MMSL
001635 NDDF
387383007 SNOMEDCT_US
69708003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Klonopin HUMAN PRESCRIPTION DRUG LABEL 1 0004-0058 TABLET 1 mg ORAL NDA 30 sections
Klonopin HUMAN PRESCRIPTION DRUG LABEL 1 0004-0068 TABLET 0.50 mg ORAL NDA 30 sections
Klonopin HUMAN PRESCRIPTION DRUG LABEL 1 0004-0098 TABLET 2 mg ORAL NDA 30 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-0832 TABLET 0.50 mg ORAL ANDA 20 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3212 TABLET 1 mg ORAL ANDA 20 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3213 TABLET 2 mg ORAL ANDA 20 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0185-0063 TABLET 0.50 mg ORAL ANDA 24 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0185-0064 TABLET 1 mg ORAL ANDA 24 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0185-0065 TABLET 2 mg ORAL ANDA 24 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-3003 TABLET 0.50 mg ORAL ANDA 24 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-3004 TABLET 1 mg ORAL ANDA 24 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-3005 TABLET 2 mg ORAL ANDA 24 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0094 TABLET, ORALLY DISINTEGRATING 0.13 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0095 TABLET, ORALLY DISINTEGRATING 0.25 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0096 TABLET, ORALLY DISINTEGRATING 0.50 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0097 TABLET, ORALLY DISINTEGRATING 1 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0098 TABLET, ORALLY DISINTEGRATING 2 mg ORAL ANDA 27 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8234 TABLET 0.50 mg ORAL ANDA 26 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8235 TABLET 1 mg ORAL ANDA 26 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8236 TABLET 2 mg ORAL ANDA 26 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0781-5567 TABLET 1 mg ORAL ANDA 24 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0781-5569 TABLET 2 mg ORAL ANDA 24 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0781-8018 TABLET 0.50 mg ORAL ANDA 24 sections
CLONULLZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 16590-058 TABLET 0.50 mg ORAL ANDA 23 sections
CLONULLZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 16590-059 TABLET 1 mg ORAL ANDA 23 sections
CLONULLZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 16590-481 TABLET 2 mg ORAL ANDA 23 sections
KLONOPIN HUMAN PRESCRIPTION DRUG LABEL 1 16590-693 TABLET 0.50 mg ORAL NDA 25 sections
KLONOPIN HUMAN PRESCRIPTION DRUG LABEL 1 16590-935 TABLET 1 mg ORAL NDA 26 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 16714-469 TABLET 0.50 mg ORAL ANDA 18 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 16714-470 TABLET 1 mg ORAL ANDA 18 sections