clonazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diazepam derivatives	703	1622-61-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: clonazepam lonazep klonopin	An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses. Molecular weight: 315.71 Formula: C15H10ClN3O3 CLOGP: 2.38 LIPINSKI: 0 HAC: 6 HDO: 1 TPSA: 87.28 ALOGS: -4.47 ROTB: 2 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

clonazepam
lonazep
klonopin

An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.

Molecular weight: 315.71
Formula: C15H10ClN3O3
CLOGP: 2.38
LIPINSKI: 0
HAC: 6
HDO: 1
TPSA: 87.28
ALOGS: -4.47
ROTB: 2

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
8	mg	O
8	mg	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.10 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.42 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	98 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	2.90 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	0.88 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.15 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	38 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
June 4, 1975	FDA	ROCHE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	2195.81	9.84	2542	180847	129347	50292388
Toxicity to various agents	808.09	9.84	2126	181263	210373	50211362
Suicide attempt	596.45	9.84	832	182557	50900	50370835
Drug abuse	534.48	9.84	854	182535	58992	50362743
Suicidal ideation	448.14	9.84	756	182633	54629	50367106
Contraindicated product administered	432.66	9.84	27	183362	148931	50272804
Respiratory arrest	428.21	9.84	536	182853	29473	50392262
Synovitis	383.41	9.84	15	183374	123850	50297885
Depression	377.64	9.84	1387	182002	164036	50257699
Intentional overdose	377.63	9.84	752	182637	61752	50359983
Seizure	352.88	9.84	1083	182306	116791	50304944
Cardio-respiratory arrest	351.85	9.84	670	182719	53222	50368513
Somnolence	342.42	9.84	1286	182103	153699	50268036
Drug withdrawal syndrome	321.73	9.84	425	182964	24656	50397079
Overdose	320.85	9.84	940	182449	98787	50322948
Systemic lupus erythematosus	319.67	9.84	61	183328	140561	50281174
Anxiety	309.27	9.84	1369	182020	176237	50245498
Sopor	307.71	9.84	370	183019	19509	50402226
Hand deformity	285.46	9.84	20	183369	100179	50321556
Psychotic disorder	283.46	9.84	372	183017	21440	50400295
Drug intolerance	278.67	9.84	231	183158	218873	50202862
Glossodynia	262.91	9.84	50	183339	115519	50306216
Cardiac arrest	247.79	9.84	766	182623	82885	50338850
Rheumatoid arthritis	243.68	9.84	225	183164	202325	50219410
Infusion related reaction	238.39	9.84	161	183228	169396	50252339
Joint swelling	234.75	9.84	328	183061	244958	50176777
Treatment failure	227.50	9.84	107	183282	137530	50284205
Tremor	226.40	9.84	920	182469	113983	50307752
Irritability	220.55	9.84	381	183008	28045	50393690
Arthropathy	217.89	9.84	153	183236	157753	50263982
Pericarditis	209.57	9.84	21	183368	78668	50343067
Schizophrenia	193.47	9.84	182	183207	7215	50414520
Drug dependence	191.58	9.84	293	183096	19466	50402269
Stubbornness	184.77	9.84	60	183329	225	50421510
Swelling	182.89	9.84	278	183111	200594	50221141
Agitation	179.07	9.84	511	182878	52873	50368862
Rash	178.81	9.84	897	182492	436574	49985161
Intentional self-injury	170.49	9.84	303	183086	22809	50398926
Alopecia	168.87	9.84	401	182988	244646	50177089
Acute kidney injury	167.88	9.84	360	183029	227698	50194037
Poisoning	167.74	9.84	216	183173	12213	50409522
Panic attack	165.67	9.84	271	183118	19071	50402664
Wound	163.19	9.84	90	183299	105704	50316031
Insomnia	162.06	9.84	1137	182252	173728	50248007
Rheumatoid factor positive	154.34	9.84	6	183383	49853	50371882
Hypersensitivity	153.93	9.84	345	183044	214816	50206919
Abdominal discomfort	152.57	9.84	388	183001	231253	50190482
Helicobacter infection	147.28	9.84	8	183381	49694	50372041
Drug hypersensitivity	145.64	9.84	447	182942	250563	50171172
Withdrawal syndrome	144.67	9.84	242	183147	17348	50404387
Neuroleptic malignant syndrome	143.31	9.84	189	183200	10941	50410794
Abnormal behaviour	140.24	9.84	254	183135	19404	50402331
Infection	136.61	9.84	262	183127	172692	50249043
Intentional product misuse	135.56	9.84	425	182964	46309	50375426
Anger	134.57	9.84	185	183204	11148	50410587
Febrile neutropenia	134.17	9.84	95	183294	97572	50324163
Dyskinesia	131.06	9.84	303	183086	27558	50394177
Unresponsive to stimuli	130.07	9.84	320	183069	30289	50391446
Maternal exposure during pregnancy	129.74	9.84	238	183151	159540	50262195
Mental disorder	129.61	9.84	262	183127	21729	50400006
Disturbance in attention	129.33	9.84	323	183066	30863	50390872
Mania	127.82	9.84	177	183212	10739	50410996
Anaemia	120.68	9.84	488	182901	251968	50169767
Thinking abnormal	119.40	9.84	160	183229	9407	50412328
Speech disorder	117.95	9.84	339	183050	35209	50386526
Aggression	117.87	9.84	246	183143	20870	50400865
Mood altered	114.89	9.84	183	183206	12590	50409145
Dystonia	113.01	9.84	175	183214	11751	50409984
Arthralgia	112.73	9.84	1032	182357	437670	49984065
Nightmare	111.14	9.84	205	183184	15881	50405854
Crying	110.65	9.84	235	183154	20181	50401554
Tardive dyskinesia	110.20	9.84	134	183255	7145	50414590
Ataxia	109.83	9.84	187	183202	13599	50408136
Discomfort	109.55	9.84	139	183250	108241	50313494
Stomatitis	108.79	9.84	124	183265	101220	50320515
Hyperhidrosis	108.50	9.84	623	182766	88803	50332932
Muscle injury	106.84	9.84	7	183382	37104	50384631
General physical health deterioration	106.25	9.84	223	183166	142211	50279524
Restless legs syndrome	105.35	9.84	199	183190	15698	50406037
Therapeutic product effect decreased	104.02	9.84	210	183179	135840	50285895
Lower respiratory tract infection	102.71	9.84	116	183273	95085	50326650
Amnesia	102.68	9.84	362	183027	41898	50379837
Serotonin syndrome	102.51	9.84	256	183133	24457	50397278
Memory impairment	102.31	9.84	562	182827	78798	50342937
Feeling abnormal	101.90	9.84	791	182598	124701	50297034
Folliculitis	100.53	9.84	12	183377	39213	50382522
Neutropenia	99.54	9.84	245	183144	147720	50274015
Depressed level of consciousness	99.06	9.84	412	182977	51541	50370194
Paranoia	96.87	9.84	151	183238	10197	50411538
Thrombocytopenia	96.81	9.84	198	183191	127475	50294260
Drooling	93.78	9.84	86	183303	3298	50418437
Hallucination	93.70	9.84	376	183013	46281	50375454
Drug interaction	92.96	9.84	1119	182270	198502	50223233
Peripheral swelling	90.43	9.84	411	182978	205525	50216210
Atrial fibrillation	87.59	9.84	146	183243	101599	50320136
Sedation	87.50	9.84	277	183112	30333	50391402
Feeling of despair	86.52	9.84	66	183323	1952	50419783
Gastric pH decreased	86.41	9.84	44	183345	618	50421117
Impaired healing	84.42	9.84	77	183312	69709	50352026
Hepatic enzyme increased	84.39	9.84	238	183151	137142	50284593
Diarrhoea	83.56	9.84	1567	181822	586909	49834826
Nervousness	82.52	9.84	254	183135	27397	50394338
Muscle rigidity	81.85	9.84	136	183253	9693	50412042
Dissociation	81.22	9.84	67	183322	2224	50419511
Balance disorder	81.21	9.84	485	182904	70105	50351630
Drug withdrawal convulsions	80.46	9.84	54	183335	1299	50420436
Multiple sclerosis	78.48	9.84	206	183183	20287	50401448
Sepsis	78.20	9.84	235	183154	132690	50289045
Cogwheel rigidity	78.14	9.84	59	183330	1718	50420017
Sensitisation	77.37	9.84	56	183333	1526	50420209
Mood swings	75.56	9.84	174	183215	15780	50405955
Mydriasis	75.39	9.84	137	183252	10490	50411245
Off label use	74.69	9.84	1240	182149	473186	49948549
Restlessness	73.97	9.84	230	183159	24943	50396792
Dysarthria	73.17	9.84	299	183090	37104	50384631
Bradyphrenia	72.39	9.84	100	183289	6052	50415683
Malignant neoplasm progression	72.39	9.84	84	183305	68040	50353695
Polycystic ovaries	70.54	9.84	64	183325	2420	50419315
Multiple sclerosis relapse	69.95	9.84	325	183064	42639	50379096
Product substitution issue	68.45	9.84	155	183234	13902	50407833
Disease progression	68.23	9.84	154	183235	95712	50326023
Derealisation	67.67	9.84	44	183345	1002	50420733
Bipolar disorder	66.62	9.84	101	183288	6656	50415079
Drug ineffective	65.53	9.84	2372	181017	816961	49604774
Sleep disorder due to general medical condition, insomnia type	64.64	9.84	17	183372	31430	50390305
Ejection fraction	64.51	9.84	45	183344	1155	50420580
Hypersomnia	63.89	9.84	159	183230	15155	50406580
Hallucination, auditory	63.43	9.84	128	183261	10600	50411135
Pancytopenia	63.10	9.84	131	183258	83899	50337836
Dyspnoea	62.78	9.84	1509	181880	546099	49875636
Pleural effusion	62.00	9.84	126	183263	81328	50340407
Loss of consciousness	61.90	9.84	614	182775	103739	50317996
Gastrointestinal disorder	60.71	9.84	160	183229	94296	50327439
Vision blurred	60.65	9.84	490	182899	78157	50343578
Mucosal inflammation	60.64	9.84	35	183354	40107	50381628
Emotional disorder	60.42	9.84	133	183256	11703	50410032
Respiratory depression	59.11	9.84	133	183256	11877	50409858
Cardiac failure	57.55	9.84	118	183271	75922	50345813
Interstitial lung disease	57.11	9.84	65	183324	53111	50368624
Drug screen negative	57.00	9.84	25	183364	245	50421490
Renal impairment	56.77	9.84	118	183271	75543	50346192
Nasopharyngitis	56.51	9.84	438	182951	192489	50229246
Lactic acidosis	56.50	9.84	25	183364	33330	50388405
Akathisia	54.51	9.84	103	183286	8126	50413609
Gastrointestinal haemorrhage	54.46	9.84	115	183274	73206	50348529
Disorientation	53.11	9.84	262	183127	35222	50386513
Delusion	53.09	9.84	118	183271	10451	50411284
H1N1 influenza	53.09	9.84	45	183344	1552	50420183
Myocardial stunning	51.52	9.84	20	183369	139	50421596
Exposure via ingestion	51.48	9.84	57	183332	2746	50418989
Jaundice cholestatic	51.25	9.84	77	183312	5034	50416701
Depersonalisation/derealisation disorder	50.96	9.84	39	183350	1159	50420576
Therapeutic response unexpected	50.12	9.84	149	183240	15766	50405969
Irritable bowel syndrome	49.88	9.84	68	183321	51373	50370362
Head injury	49.36	9.84	195	183194	23825	50397910
Rheumatic fever	49.09	9.84	3	183386	16864	50404871
Incontinence	48.50	9.84	110	183279	9875	50411860
Granulocytopenia	48.50	9.84	76	183313	5155	50416580
Gait disturbance	48.33	9.84	788	182601	149217	50272518
Bone marrow failure	47.92	9.84	20	183369	27604	50394131
Lethargy	47.79	9.84	325	183064	49107	50372628
Bradykinesia	47.76	9.84	65	183324	3878	50417857
Mental status changes	46.80	9.84	257	183132	36015	50385720
Major depression	46.63	9.84	87	183302	6797	50414938
Migraine	46.62	9.84	447	182942	74833	50346902
Depressed mood	46.57	9.84	245	183144	33778	50387957
Status epilepticus	46.56	9.84	130	183259	13276	50408459
Weight increased	46.53	9.84	1007	182382	200884	50220851
Coma	46.38	9.84	359	183030	56520	50365215
Abnormal dreams	46.33	9.84	104	183285	9273	50412462
Personality disorder	46.03	9.84	67	183322	4257	50417478
Feeling of body temperature change	45.52	9.84	67	183322	4300	50417435
Herpes zoster	45.41	9.84	120	183269	70666	50351069
Myoglobin urine present	45.39	9.84	24	183365	366	50421369
On and off phenomenon	45.33	9.84	39	183350	1373	50420362
Hip arthroplasty	45.30	9.84	27	183362	30402	50391333
Epilepsy	45.05	9.84	176	183213	21391	50400344
Hyperprolactinaemia	44.65	9.84	58	183331	3307	50418428
Multiple-drug resistance	43.78	9.84	57	183332	3257	50418478
Dizziness	43.61	9.84	1599	181790	344770	50076965
Knee arthroplasty	42.81	9.84	40	183349	35806	50385929
Substance abuse	42.59	9.84	63	183326	4061	50417674
Electrocardiogram QT prolonged	42.59	9.84	328	183061	51558	50370177
Myocardial depression	42.17	9.84	24	183365	426	50421309
Decorticate posture	42.07	9.84	21	183368	282	50421453
Blood creatinine increased	41.71	9.84	139	183250	76021	50345714
Middle insomnia	41.38	9.84	103	183286	9818	50411917
Parkinsonism	41.36	9.84	96	183293	8751	50412984
Cardiac failure congestive	40.93	9.84	162	183227	84220	50337515
Sluggishness	40.75	9.84	64	183325	4349	50417386
Product use issue	40.70	9.84	346	183043	149129	50272606
Stress	40.30	9.84	333	183056	53460	50368275
Platelet count decreased	40.11	9.84	208	183181	100518	50321217
Pleurothotonus	39.88	9.84	35	183354	1266	50420469
Dysphoria	39.68	9.84	66	183323	4708	50417027
Palmar-plantar erythrodysaesthesia syndrome	39.20	9.84	12	183377	20086	50401649
Muscle spasms	39.12	9.84	656	182733	124897	50296838
Menstrual disorder	38.46	9.84	62	183327	4308	50417427
Melaena	38.38	9.84	25	183364	26839	50394896
Hypoaesthesia oral	38.21	9.84	105	183284	10623	50411112
Breast hyperplasia	38.07	9.84	19	183370	255	50421480
Atonic seizures	37.78	9.84	25	183364	587	50421148
Drug use disorder	37.76	9.84	51	183338	3021	50418714
Myelosuppression	37.61	9.84	3	183386	13514	50408221
Impaired driving ability	37.35	9.84	58	183331	3903	50417832
C-reactive protein increased	37.31	9.84	120	183269	66354	50355381
Hypercalcaemia	37.26	9.84	19	183370	23333	50398402
Neutrophil count decreased	36.92	9.84	69	183320	45957	50375778
Dopamine dysregulation syndrome	36.20	9.84	16	183373	160	50421575
Movement disorder	36.11	9.84	143	183246	17489	50404246
Hallucinations, mixed	35.82	9.84	58	183331	4045	50417690
Osteonecrosis of jaw	35.75	9.84	39	183350	32487	50389248
Psychomotor hyperactivity	35.10	9.84	93	183296	9208	50412527
Skin ulcer	34.94	9.84	46	183343	35272	50386463
Fall	34.87	9.84	1515	181874	333417	50088318
Blister	34.79	9.84	175	183214	85243	50336492
Urinary retention	34.75	9.84	187	183202	26003	50395732
Rhinitis allergic	34.62	9.84	79	183310	7121	50414614
Persecutory delusion	34.61	9.84	43	183346	2344	50419391
Galactorrhoea	34.39	9.84	54	183335	3669	50418066
Broncholithiasis	34.20	9.84	15	183374	147	50421588
Sleep apnoea syndrome	34.14	9.84	174	183215	23694	50398041
Pneumocystis jirovecii pneumonia	34.06	9.84	6	183383	14657	50407078
Hostility	34.05	9.84	37	183352	1745	50419990
Product complaint	33.90	9.84	105	183284	11361	50410374
Drug screen positive	33.75	9.84	51	183338	3351	50418384
Hyperkalaemia	33.59	9.84	78	183311	48011	50373724
Hypokinesia	33.49	9.84	109	183280	12108	50409627
Incoherent	33.19	9.84	57	183332	4173	50417562
Hypomania	33.13	9.84	59	183330	4446	50417289
Aphasia	32.89	9.84	196	183193	28298	50393437
Therapeutic product ineffective	32.73	9.84	31	183358	1239	50420496
Sleep-related eating disorder	32.67	9.84	25	183364	743	50420992
Stoma site discharge	32.63	9.84	31	183358	1244	50420491
Ill-defined disorder	32.56	9.84	96	183293	54558	50367177
Parosmia	32.50	9.84	58	183331	4378	50417357
Nystagmus	32.46	9.84	66	183323	5495	50416240
Fear	32.25	9.84	121	183268	14428	50407307
Oromandibular dystonia	32.18	9.84	20	183369	420	50421315
Adjustment disorder with mixed anxiety and depressed mood	32.12	9.84	12	183377	74	50421661
Pain	32.03	9.84	1744	181645	577159	49844576
Heart rate increased	32.02	9.84	424	182965	76826	50344909
Rubber sensitivity	31.87	9.84	36	183353	1773	50419962
Coma blister	31.58	9.84	14	183375	141	50421594
Libido increased	31.39	9.84	30	183359	1213	50420522
Electroencephalogram abnormal	31.28	9.84	50	183339	3449	50418286
Miosis	31.19	9.84	70	183319	6240	50415495
Panic disorder	31.03	9.84	40	183349	2263	50419472
Nephrectomy	30.82	9.84	25	183364	810	50420925
Muscle disorder	30.76	9.84	56	183333	4294	50417441
Haemoglobin decreased	30.50	9.84	304	183085	126912	50294823
Toxic encephalopathy	30.48	9.84	64	183325	5451	50416284
Emotional distress	30.46	9.84	193	183196	28470	50393265
Generalised tonic-clonic seizure	30.39	9.84	181	183208	26129	50395606
Catatonia	30.18	9.84	51	183338	3685	50418050
Septic shock	30.18	9.84	106	183283	57069	50364666
Feeling jittery	30.08	9.84	99	183290	11061	50410674
Autonomic nervous system imbalance	29.93	9.84	40	183349	2345	50419390
Renal failure	29.84	9.84	245	183144	106388	50315347
Tension	29.69	9.84	43	183346	2719	50419016
Pulmonary fibrosis	29.50	9.84	27	183362	24410	50397325
Road traffic accident	29.07	9.84	169	183220	24183	50397552
Leukopenia	28.86	9.84	136	183253	67392	50354343
Hereditary angioedema	28.74	9.84	62	183327	5380	50416355
Lymph node calcification	28.70	9.84	15	183374	223	50421512
Anaphylactic reaction	28.68	9.84	100	183289	53955	50367780
Developmental glaucoma	28.03	9.84	10	183379	53	50421682
Bruxism	27.95	9.84	44	183345	2996	50418739
Muscle twitching	27.56	9.84	120	183269	15311	50406424
Mobility decreased	27.56	9.84	173	183216	79775	50341960
Angioedema	27.22	9.84	60	183329	37616	50384119
Tinnitus	27.21	9.84	185	183204	27947	50393788
Pneumonia aspiration	27.13	9.84	199	183190	30805	50390930
Anticonvulsant drug level above therapeutic	27.02	9.84	19	183370	494	50421241
Plasma cell myeloma	26.89	9.84	45	183344	31277	50390458
Right ventricular failure	26.78	9.84	12	183377	15881	50405854
Cytomegalovirus infection	26.65	9.84	16	183373	17946	50403789
Panic reaction	26.58	9.84	47	183342	3522	50418213
Urinary bladder rupture	26.55	9.84	12	183377	127	50421608
Urticaria	26.51	9.84	321	183068	129240	50292495
Hypocalcaemia	26.45	9.84	35	183354	26781	50394954
Affect lability	26.23	9.84	82	183307	8916	50412819
Obsessive-compulsive disorder	26.20	9.84	45	183344	3295	50418440
Extrapyramidal disorder	26.18	9.84	98	183291	11672	50410063
Apathy	26.02	9.84	73	183316	7475	50414260
Head titubation	25.85	9.84	21	183368	682	50421053
Mutism	25.22	9.84	28	183361	1353	50420382
Rash pruritic	25.06	9.84	89	183300	47757	50373978
Neutropenic sepsis	24.93	9.84	10	183379	14137	50407598
Influenza like illness	24.91	9.84	318	183071	57141	50364594
Formication	24.60	9.84	46	183343	3600	50418135
Paralysis	24.38	9.84	78	183311	8586	50413149
Proteinuria	24.32	9.84	15	183374	16582	50405153
Device expulsion	24.20	9.84	42	183347	28780	50392955
Upper gastrointestinal haemorrhage	24.19	9.84	14	183375	16021	50405714
Psychomotor retardation	24.16	9.84	44	183345	3374	50418361
Coordination abnormal	23.99	9.84	94	183295	11440	50410295
Fibromyalgia	23.96	9.84	259	183130	44719	50377016
Sensory loss	23.94	9.84	72	183317	7666	50414069
Aspiration	23.92	9.84	81	183308	9183	50412552
Post-traumatic neck syndrome	23.92	9.84	32	183357	1878	50419857
Anorgasmia	23.46	9.84	18	183371	537	50421198
Urinary tract discomfort	23.28	9.84	13	183376	222	50421513
Sinusitis	23.17	9.84	457	182932	170101	50251634
Neoplasm progression	23.13	9.84	44	183345	29113	50392622
Dysphagia	23.03	9.84	402	182987	77116	50344619
Inflammation	22.94	9.84	117	183272	56795	50364940
Blood creatine phosphokinase increased	22.94	9.84	169	183220	26198	50395537
Neuropathy peripheral	22.86	9.84	232	183157	96525	50325210
Blood sodium decreased	22.85	9.84	143	183246	21004	50400731
Bone erosion	22.76	9.84	7	183382	11680	50410055
Erythema	22.48	9.84	384	183005	146030	50275705
Musculoskeletal pain	22.46	9.84	161	183228	72016	50349719
Tachyphrenia	22.32	9.84	25	183364	1220	50420515
Oropharyngeal oedema	22.25	9.84	13	183376	243	50421492
Transplant rejection	22.17	9.84	4	183385	9605	50412130
Musculoskeletal stiffness	22.05	9.84	330	183059	128151	50293584
Confusional state	22.05	9.84	853	182536	185075	50236660
Hyperbilirubinaemia	22.04	9.84	4	183385	9566	50412169
Pruritus	21.99	9.84	823	182566	282745	50138990
Conversion disorder	21.95	9.84	28	183361	1568	50420167
Logorrhoea	21.87	9.84	34	183355	2290	50419445
Suspected suicide	21.69	9.84	55	183334	5302	50416433
Sleep disorder	21.53	9.84	309	183080	56974	50364761
Dependence	21.35	9.84	30	183359	1845	50419890
Hyperammonaemic encephalopathy	21.31	9.84	31	183358	1968	50419767
Libido decreased	21.31	9.84	34	183355	2342	50419393
Hyponatraemia	21.30	9.84	234	183155	95905	50325830
Band neutrophil percentage increased	21.29	9.84	12	183377	209	50421526
Metastases to liver	21.12	9.84	25	183364	20079	50401656
Exposure during pregnancy	21.06	9.84	310	183079	120705	50301030
Alcohol abuse	21.03	9.84	30	183359	1871	50419864
Freezing phenomenon	21.03	9.84	22	183367	993	50420742
Forced expiratory volume decreased	20.89	9.84	48	183341	4346	50417389
Adverse drug reaction	20.88	9.84	116	183273	55106	50366629
Liver function test increased	20.88	9.84	38	183351	25568	50396167
Pyrexia	20.85	9.84	1146	182243	379057	50042678
Stoma site hypergranulation	20.79	9.84	13	183376	276	50421459
Drug abuser	20.75	9.84	37	183352	2791	50418944
Abulia	20.62	9.84	15	183374	412	50421323
Peroneal nerve palsy	20.60	9.84	47	183342	4236	50417499
Pulmonary arterial hypertension	20.57	9.84	26	183363	20293	50401442
Suicidal behaviour	20.39	9.84	33	183356	2301	50419434
Soft tissue injury	20.35	9.84	26	183363	1458	50420277
Cognitive disorder	20.33	9.84	247	183142	43876	50377859
Weight gain poor	20.30	9.84	19	183370	748	50420987
Intervertebral disc protrusion	20.25	9.84	135	183254	20258	50401477
Dysstasia	20.20	9.84	122	183267	17697	50404038
Hyperreflexia	20.16	9.84	52	183337	5066	50416669
Euphoric mood	20.06	9.84	45	183344	4010	50417725
Carpal tunnel syndrome	20.01	9.84	117	183272	16776	50404959
Creatinine renal clearance decreased	19.97	9.84	9	183380	11872	50409863
Diverticulitis	19.97	9.84	58	183331	33124	50388611
Ascites	19.94	9.84	65	183324	35796	50385939
Stereotypy	19.78	9.84	14	183375	368	50421367
Antidepressant drug level above therapeutic	19.75	9.84	14	183375	369	50421366
Intellectual disability	19.74	9.84	19	183370	775	50420960
Urinary incontinence	19.73	9.84	172	183217	28036	50393699
Dysgraphia	19.65	9.84	35	183354	2638	50419097
Weight abnormal	19.52	9.84	21	183368	979	50420756
Tongue discolouration	19.52	9.84	36	183353	2788	50418947
Antipsychotic drug level increased	19.47	9.84	38	183351	3071	50418664
Attention deficit hyperactivity disorder	19.41	9.84	33	183356	2396	50419339
Food craving	19.40	9.84	25	183364	1414	50420321
Screaming	19.38	9.84	37	183352	2941	50418794
Anaphylactic shock	19.18	9.84	27	183362	20128	50401607
Impulsive behaviour	19.14	9.84	25	183364	1433	50420302
Concussion	19.09	9.84	66	183323	7562	50414173
Acute myeloid leukaemia	18.98	9.84	16	183373	15058	50406677
Pneumonitis	18.94	9.84	50	183339	29460	50392275
Hypervolaemia	18.92	9.84	40	183349	25459	50396276
Hypertension	18.90	9.84	602	182787	210601	50211134
Altered state of consciousness	18.81	9.84	140	183249	21770	50399965
Psoriatic arthropathy	18.78	9.84	97	183292	46935	50374800
Blood test abnormal	18.69	9.84	86	183303	11233	50410502
Colitis	18.66	9.84	74	183315	38455	50383280
Cerebellar atrophy	18.58	9.84	17	183372	650	50421085
Seizure cluster	18.57	9.84	11	183378	211	50421524
Delirium	18.56	9.84	216	183173	37976	50383759
Macular degeneration	18.46	9.84	15	183374	14373	50407362
Bipolar I disorder	18.35	9.84	25	183364	1493	50420242
Somnambulism	18.34	9.84	49	183340	4875	50416860
Decreased interest	18.18	9.84	36	183353	2940	50418795
Initial insomnia	18.15	9.84	50	183339	5065	50416670
Anticonvulsant drug level below therapeutic	18.13	9.84	16	183373	583	50421152
Cholelithiasis	18.12	9.84	214	183175	37759	50383976
Myocardial infarction	18.04	9.84	221	183168	88806	50332929
Psychotic disorder due to a general medical condition	18.04	9.84	11	183378	223	50421512
Hypokalaemia	18.00	9.84	218	183171	87774	50333961
Blood triglycerides increased	17.98	9.84	85	183304	11227	50410508
White blood cell count decreased	17.96	9.84	306	183083	116416	50305319
Epistaxis	17.86	9.84	147	183242	63807	50357928
Alveolar osteitis	17.81	9.84	14	183375	433	50421302
Tic	17.77	9.84	22	183367	1195	50420540
Stoma site pain	17.71	9.84	18	183371	785	50420950
Live birth	17.67	9.84	20	183369	16388	50405347
Jaundice	17.56	9.84	44	183345	26385	50395350
Psychiatric symptom	17.56	9.84	46	183343	4524	50417211
Cytopenia	17.55	9.84	5	183384	8770	50412965
Trismus	17.52	9.84	38	183351	3310	50418425
Tunnel vision	17.49	9.84	17	183372	702	50421033
Mitral valve thickening	17.34	9.84	5	183384	11	50421724
Red blood cell sedimentation rate increased	17.28	9.84	52	183337	29364	50392371
Post-traumatic stress disorder	17.24	9.84	44	183345	4259	50417476
Sexual abuse	16.98	9.84	9	183380	138	50421597
Pulmonary hypertension	16.94	9.84	63	183326	33354	50388381
Social anxiety disorder	16.94	9.84	13	183376	388	50421347
Drug tolerance decreased	16.93	9.84	6	183383	9154	50412581
Hypothermia	16.76	9.84	87	183302	11929	50409806
Choking	16.66	9.84	68	183321	8430	50413305
Hypomagnesaemia	16.62	9.84	37	183352	23119	50398616
Neuropsychiatric symptoms	16.60	9.84	15	183374	564	50421171
Enthesopathy	16.58	9.84	3	183386	7190	50414545
Salivary hypersecretion	16.47	9.84	57	183332	6534	50415201
Change in seizure presentation	16.38	9.84	11	183378	265	50421470
Myelocyte percentage increased	16.34	9.84	10	183379	204	50421531
Peripheral pulse decreased	16.34	9.84	6	183383	35	50421700
Blood parathyroid hormone decreased	16.33	9.84	3	183386	7111	50414624
Injection site pruritus	16.33	9.84	83	183306	40328	50381407
Shock haemorrhagic	16.24	9.84	5	183384	8339	50413396
Stoma site erythema	16.16	9.84	18	183371	873	50420862
Blood growth hormone increased	15.95	9.84	13	183376	424	50421311
Intentional product use issue	15.95	9.84	190	183199	76728	50345007
Hypnopompic hallucination	15.93	9.84	6	183383	38	50421697
Thrombotic microangiopathy	15.84	9.84	6	183383	8785	50412950
Liver function test abnormal	15.77	9.84	95	183294	44244	50377491
Myoclonus	15.73	9.84	98	183291	14372	50407363
Hyperkeratosis	15.72	9.84	47	183342	4988	50416747
Femur fracture	15.68	9.84	76	183313	37388	50384347
Compulsive shopping	15.66	9.84	16	183373	702	50421033
Hypoventilation	15.61	9.84	40	183349	3881	50417854
Anticonvulsant drug level increased	15.54	9.84	22	183367	1362	50420373
Metabolic acidosis	15.54	9.84	80	183309	38745	50382990
Haematochezia	15.50	9.84	83	183306	39799	50381936
Weight decreased	15.48	9.84	964	182425	220281	50201454
Basal cell carcinoma	15.43	9.84	39	183350	23317	50398418
Cytokine release syndrome	15.38	9.84	6	183383	8628	50413107
Coma scale abnormal	15.34	9.84	45	183344	4726	50417009
Monocyte count abnormal	15.32	9.84	9	183380	170	50421565
Visual impairment	15.20	9.84	339	183050	67936	50353799
Upper respiratory tract infection	15.15	9.84	159	183230	65739	50355996
Narcotic bowel syndrome	15.13	9.84	8	183381	122	50421613
Alcohol poisoning	15.11	9.84	25	183364	1775	50419960
Tearfulness	15.08	9.84	38	183351	3649	50418086
Flat affect	15.04	9.84	21	183368	1284	50420451
Pupil fixed	15.02	9.84	23	183366	1529	50420206
Full blood count decreased	15.00	9.84	37	183352	22309	50399426
Increased appetite	14.91	9.84	65	183324	8296	50413439
Self-injurious ideation	14.89	9.84	28	183361	2201	50419534
Diplopia	14.83	9.84	120	183269	19140	50402595
Arthritis	14.79	9.84	223	183166	86498	50335237
Metastases to lung	14.76	9.84	11	183378	11009	50410726
Impulse-control disorder	14.74	9.84	15	183374	655	50421080
Anhedonia	14.73	9.84	71	183318	9453	50412282
Lupus-like syndrome	14.73	9.84	8	183381	9483	50412252
Feelings of worthlessness	14.73	9.84	11	183378	315	50421420
Burning sensation	14.71	9.84	239	183150	45207	50376528
Hyperammonaemia	14.66	9.84	44	183345	4680	50417055
Poor quality sleep	14.65	9.84	107	183282	16539	50405196
Disorganised speech	14.61	9.84	18	183371	973	50420762
Vomiting	14.57	9.84	1455	181934	459303	49962432
Enuresis	14.54	9.84	27	183362	2102	50419633
Drug ineffective for unapproved indication	14.49	9.84	129	183260	21152	50400583
Limb injury	14.44	9.84	124	183265	20126	50401609
Congenital jaw malformation	14.42	9.84	5	183384	24	50421711
Cerebral atrophy	14.41	9.84	43	183346	4558	50417177
Therapy non-responder	14.37	9.84	117	183272	50905	50370830
Disseminated intravascular coagulation	14.36	9.84	25	183364	17110	50404625
Prescribed underdose	14.31	9.84	103	183286	15846	50405889
Flight of ideas	14.26	9.84	11	183378	331	50421404
Right ventricular systolic pressure decreased	14.25	9.84	5	183384	25	50421710
Suspected product quality issue	14.19	9.84	9	183380	196	50421539
Hypoaesthesia	14.18	9.84	580	182809	126677	50295058
Cyanosis	14.18	9.84	99	183290	15085	50406650
Ketosis-prone diabetes mellitus	14.13	9.84	4	183385	8	50421727
Cast application	14.09	9.84	5	183384	26	50421709
Motor dysfunction	14.00	9.84	62	183327	7969	50413766
Electrocardiogram QRS complex shortened	13.96	9.84	12	183377	422	50421313
Infantile spasms	13.92	9.84	9	183380	203	50421532
Bladder pain	13.82	9.84	23	183366	1641	50420094
Blood prolactin increased	13.80	9.84	33	183356	3066	50418669
Pericardial effusion	13.80	9.84	47	183342	25542	50396193
Parkinsonian gait	13.77	9.84	12	183377	430	50421305
Secretion discharge	13.74	9.84	71	183318	9720	50412015
Stupor	13.70	9.84	36	183353	3547	50418188
Drug level above therapeutic	13.60	9.84	38	183351	3882	50417853
International normalised ratio increased	13.55	9.84	96	183293	43056	50378679
Circulatory collapse	13.52	9.84	33	183356	19967	50401768
Homicidal ideation	13.44	9.84	23	183366	1679	50420056
Sensitivity to weather change	13.38	9.84	50	183339	5951	50415784
Feeling drunk	13.25	9.84	36	183353	3617	50418118
Sternal fracture	13.19	9.84	25	183364	1977	50419758
Hallucination, visual	13.14	9.84	104	183285	16478	50405257
Fear of injection	13.13	9.84	3	183386	6100	50415635
Torticollis	13.11	9.84	23	183366	1713	50420022
Drop attacks	13.10	9.84	14	183375	648	50421087
Sebaceous gland infection	13.05	9.84	7	183382	110	50421625
Dysphemia	13.02	9.84	27	183362	2279	50419456
Nephrogenic diabetes insipidus	12.98	9.84	16	183373	865	50420870
Headache	12.98	9.84	2057	181332	504478	49917257
Prescribed overdose	12.94	9.84	94	183295	14506	50407229
Paraesthesia	12.93	9.84	546	182843	119697	50302038
Tonic clonic movements	12.92	9.84	19	183370	1218	50420517
Cushingoid	12.90	9.84	4	183385	6641	50415094
Haemoglobin urine	12.89	9.84	7	183382	113	50421622
Areflexia	12.81	9.84	30	183359	2750	50418985
Cholestasis	12.80	9.84	48	183341	25353	50396382
Aerophagia	12.76	9.84	4	183385	13	50421722
Abdominal pain	12.74	9.84	713	182676	235515	50186220
Mental impairment	12.74	9.84	81	183308	11963	50409772
Abscess	12.72	9.84	20	183369	14252	50407483
Parasomnia	12.70	9.84	11	183378	391	50421344
COVID-19	12.69	9.84	108	183281	46554	50375181
Bronchial wall thickening	12.64	9.84	16	183373	889	50420846
Product quality issue	12.62	9.84	169	183220	30689	50391046
Animal scratch	12.61	9.84	16	183373	891	50420844
Osteoporosis	12.60	9.84	103	183286	44776	50376959
Accidental overdose	12.59	9.84	117	183272	19416	50402319
Distractibility	12.58	9.84	11	183378	396	50421339
Family stress	12.55	9.84	13	183376	580	50421155
Hyperphagia	12.49	9.84	21	183368	1511	50420224
Acute myocardial infarction	12.48	9.84	59	183330	29214	50392521
Hyperacusis	12.47	9.84	23	183366	1781	50419954
Barotrauma	12.43	9.84	8	183381	179	50421556
Fatigue	12.29	9.84	2319	181070	705282	49716453
Klebsiella test positive	12.28	9.84	16	183373	915	50420820
Drug screen false positive	12.27	9.84	15	183374	804	50420931
Affective disorder	12.25	9.84	44	183345	5137	50416598
Heart rate abnormal	12.21	9.84	37	183352	3955	50417780
Clumsiness	12.18	9.84	23	183366	1813	50419922
Fluid retention	12.14	9.84	121	183268	50528	50371207
Oculogyric crisis	12.12	9.84	20	183369	1417	50420318
Focal dyscognitive seizures	12.07	9.84	29	183360	2703	50419032
Vertigo	12.06	9.84	259	183130	51573	50370162
Chronic spontaneous urticaria	12.02	9.84	12	183377	512	50421223
Temporomandibular joint syndrome	11.98	9.84	34	183355	3505	50418230
Illusion	11.91	9.84	16	183373	943	50420792
Amylase increased	11.90	9.84	45	183344	5385	50416350
Band neutrophil count increased	11.89	9.84	10	183379	341	50421394
Bradycardia neonatal	11.88	9.84	15	183374	831	50420904
Ejection fraction abnormal	11.87	9.84	15	183374	832	50420903
Eating disorder	11.86	9.84	96	183293	15313	50406422
Fractured coccyx	11.85	9.84	16	183373	947	50420788
Gaze palsy	11.85	9.84	19	183370	1314	50420421
Pathogen resistance	11.84	9.84	3	183386	5686	50416049
Periorbital swelling	11.82	9.84	23	183366	1854	50419881
Rib fracture	11.82	9.84	114	183275	19107	50402628
Large intestine operation	11.80	9.84	3	183386	3	50421732
Oculocephalogyric reflex absent	11.80	9.84	3	183386	3	50421732
Pre-existing condition improved	11.78	9.84	54	183335	7043	50414692
Haematotoxicity	11.76	9.84	7	183382	7888	50413847
Sensorimotor disorder	11.75	9.84	11	183378	433	50421302
Localised infection	11.68	9.84	50	183339	25435	50396300
Inappropriate schedule of product administration	11.67	9.84	342	183047	71489	50350246
Respiratory rate decreased	11.65	9.84	31	183358	3077	50418658
Onychophagia	11.58	9.84	5	183384	47	50421688
Uveitis	11.58	9.84	10	183379	9300	50412435
Fever neonatal	11.57	9.84	4	183385	19	50421716
Encephalopathy	11.55	9.84	179	183210	33532	50388203
Temperature intolerance	11.51	9.84	56	183333	7483	50414252
Drug detoxification	11.39	9.84	7	183382	144	50421591
Injection site erythema	11.34	9.84	197	183192	74739	50346996
Substance use disorder	11.32	9.84	6	183383	92	50421643
Behaviour disorder	11.32	9.84	26	183363	2354	50419381
Essential tremor	11.27	9.84	15	183374	876	50420859
Oliguria	11.26	9.84	8	183381	8208	50413527
Cerebral haemorrhage	11.25	9.84	55	183334	26997	50394738
Dairy intolerance	11.22	9.84	5	183384	51	50421684
Foetal growth restriction	11.17	9.84	5	183384	6622	50415113
Generalised anxiety disorder	11.10	9.84	22	183367	1798	50419937
Chronic papillomatous dermatitis	11.06	9.84	5	183384	53	50421682
Orthostatic tremor	10.95	9.84	3	183386	5	50421730
Bronchopulmonary aspergillosis	10.93	9.84	7	183382	7585	50414150
Soft tissue haemorrhage	10.93	9.84	8	183381	222	50421513
Accidental exposure to product by child	10.90	9.84	16	183373	1024	50420711
Asthma	10.84	9.84	411	182978	88926	50332809
Binge eating	10.83	9.84	10	183379	387	50421348
Automatism	10.82	9.84	5	183384	56	50421679
Body height increased	10.82	9.84	5	183384	56	50421679
Anuria	10.76	9.84	15	183374	11229	50410506
Urine oxalate increased	10.71	9.84	8	183381	229	50421506
Device difficult to use	10.70	9.84	12	183377	9874	50411861
Transfusion	10.66	9.84	19	183370	12886	50408849
Blepharospasm	10.64	9.84	29	183360	2919	50418816
Acute generalised exanthematous pustulosis	10.64	9.84	10	183379	8928	50412807
Respiratory disorder neonatal	10.63	9.84	15	183374	926	50420809
Cataplexy	10.60	9.84	16	183373	1050	50420685
Pneumonia	10.59	9.84	1205	182184	377196	50044539
Decreased activity	10.57	9.84	42	183347	5145	50416590
Multiple organ dysfunction syndrome	10.56	9.84	124	183265	50213	50371522
Device use error	10.53	9.84	3	183386	5263	50416472
Conjunctivitis allergic	10.52	9.84	13	183376	705	50421030
Hypertonia	10.49	9.84	35	183354	3938	50417797
Sleep terror	10.44	9.84	13	183376	710	50421025
Osteonecrosis	10.43	9.84	44	183345	22473	50399262
Coronary artery disease	10.41	9.84	64	183325	29662	50392073
Schizoaffective disorder	10.38	9.84	24	183365	2182	50419553
Injection site swelling	10.35	9.84	99	183290	41674	50380061
Suspiciousness	10.31	9.84	9	183380	323	50421412
Job dissatisfaction	10.28	9.84	4	183385	28	50421707
Nail disorder	10.28	9.84	12	183377	9696	50412039
Muscle contractions involuntary	10.27	9.84	22	183367	1900	50419835
Pancreatolithiasis	10.25	9.84	8	183381	245	50421490
Myoclonic epilepsy	10.22	9.84	15	183374	960	50420775
Large intestine polyp	10.17	9.84	53	183336	7279	50414456
Stoma site extravasation	10.16	9.84	8	183381	248	50421487
Feeling guilty	10.12	9.84	11	183378	519	50421216
Peritonitis	10.12	9.84	26	183363	15460	50406275
Retinal detachment	10.12	9.84	3	183386	5126	50416609
Eye pain	10.11	9.84	152	183237	28297	50393438
Hepatocellular injury	10.08	9.84	54	183335	25893	50395842
Haematemesis	10.07	9.84	59	183330	27666	50394069
Rash maculo-papular	10.05	9.84	56	183333	26585	50395150
Sleep disorder due to a general medical condition	10.03	9.84	53	183336	7318	50414417
Victim of crime	10.03	9.84	5	183384	67	50421668
Cardiac infection	10.02	9.84	9	183380	336	50421399
Haemangioma congenital	9.97	9.84	10	183379	429	50421306
Aplastic anaemia	9.92	9.84	8	183381	7695	50414040
Agitated depression	9.91	9.84	6	183383	120	50421615
Adverse event	9.89	9.84	106	183283	43657	50378078
Electrocardiogram QRS complex prolonged	9.88	9.84	42	183347	5302	50416433
Metastases to central nervous system	9.88	9.84	16	183373	11266	50410469
Soliloquy	9.86	9.84	7	183382	185	50421550

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	1149.83	10.68	1376	97796	78507	29396848
Completed suicide	798.98	10.68	1228	97944	89018	29386337
Depression	764.03	10.68	1166	98006	83981	29391374
Toxicity to various agents	574.40	10.68	1570	97602	172091	29303264
Somnolence	388.20	10.68	925	98247	93030	29382325
Sopor	302.03	10.68	268	98904	10666	29464689
Drug interaction	297.71	10.68	1379	97793	196006	29279349
Overdose	296.80	10.68	755	98417	79064	29396291
Coma	252.38	10.68	465	98707	38985	29436370
Respiratory arrest	235.56	10.68	357	98815	25476	29449879
Seizure	232.86	10.68	764	98408	92359	29382996
Neuroleptic malignant syndrome	231.18	10.68	278	98894	15870	29459485
Intentional overdose	230.11	10.68	441	98731	38087	29437268
Aggression	219.90	10.68	413	98759	35128	29440227
Suicide attempt	216.82	10.68	401	98771	33709	29441646
Poisoning	214.61	10.68	213	98959	9780	29465575
Agitation	212.49	10.68	506	98666	50798	29424557
Suicidal ideation	199.52	10.68	391	98781	34325	29441030
Anxiety	185.06	10.68	668	98504	84697	29390658
Febrile neutropenia	177.65	10.68	77	99095	112163	29363192
Cardio-respiratory arrest	174.91	10.68	466	98706	50135	29425220
Sedation	169.33	10.68	248	98924	17157	29458198
Psychotic disorder	164.28	10.68	266	98906	20088	29455267
Drug dependence	162.32	10.68	269	98903	20712	29454643
Miosis	161.50	10.68	165	99007	7844	29467511
Intentional product misuse	154.55	10.68	352	98820	34309	29441046
Abnormal behaviour	148.32	10.68	273	98899	22854	29452501
Intentional self-injury	145.75	10.68	194	98978	12267	29463088
Anaemia	145.23	10.68	284	98888	200667	29274688
Drug withdrawal syndrome	141.03	10.68	232	98940	17752	29457603
Acute kidney injury	135.92	10.68	447	98725	264820	29210535
Depressed level of consciousness	130.44	10.68	343	98829	36599	29438756
Status epilepticus	129.25	10.68	170	99002	10624	29464731
Substance abuse	126.39	10.68	134	99038	6653	29468702
Dyspnoea	124.93	10.68	618	98554	326114	29149241
Interstitial lung disease	109.63	10.68	29	99143	57689	29417666
Dyskinesia	106.88	10.68	219	98953	19842	29455513
Loss of personal independence in daily activities	104.24	10.68	250	98922	25190	29450165
Pancytopenia	100.44	10.68	79	99093	83089	29392266
Malignant neoplasm progression	99.98	10.68	62	99110	73797	29401558
Speech disorder	99.50	10.68	234	98938	23282	29452073
Hallucination	96.85	10.68	350	98822	44362	29430993
Altered state of consciousness	96.52	10.68	209	98963	19680	29455675
Insomnia	96.42	10.68	567	98605	88194	29387161
Ataxia	96.05	10.68	157	99015	11946	29463409
Diarrhoea	95.99	10.68	688	98484	332010	29143345
Cardiac arrest	95.73	10.68	551	98621	85040	29390315
Paranoia	94.99	10.68	140	99032	9737	29465618
Panic attack	94.88	10.68	128	99044	8198	29467157
Thrombocytopenia	92.62	10.68	196	98976	134627	29340728
Parkinsonism	92.40	10.68	118	99054	7160	29468195
Bradykinesia	92.21	10.68	83	99089	3364	29471991
Delusion	84.32	10.68	142	99030	11074	29464281
Sepsis	84.03	10.68	225	98947	142457	29332898
Psychiatric decompensation	83.86	10.68	56	99116	1448	29473907
Restlessness	79.56	10.68	207	98965	21938	29453417
Pneumonia aspiration	77.37	10.68	285	98887	36452	29438903
Salivary hypersecretion	77.06	10.68	109	99063	7300	29468055
Granulocytopenia	75.81	10.68	97	99075	5897	29469458
On and off phenomenon	75.73	10.68	58	99114	1870	29473485
Rash	75.23	10.68	354	98818	189465	29285890
Atrial fibrillation	74.70	10.68	151	99021	105495	29369860
Pneumonia	74.51	10.68	701	98471	319471	29155884
Drug withdrawal convulsions	73.98	10.68	47	99125	1114	29474241
Victim of crime	73.00	10.68	32	99140	341	29475014
Serotonin syndrome	72.71	10.68	173	98999	17339	29458016
Renal failure	72.11	10.68	184	98988	118415	29356940
Muscle rigidity	70.55	10.68	119	99053	9292	29466063
Dystonia	70.08	10.68	121	99051	9628	29465727
Mydriasis	70.02	10.68	94	99078	5991	29469364
Disease progression	68.86	10.68	105	99067	81811	29393544
Platelet count decreased	68.69	10.68	156	99016	104516	29370839
Pyrexia	66.32	10.68	631	98541	286991	29188364
Bradyphrenia	66.01	10.68	76	99096	4138	29471217
Psychomotor skills impaired	65.19	10.68	61	99111	2600	29472755
Myocardial infarction	64.09	10.68	175	98997	110121	29365234
Depression suicidal	63.95	10.68	45	99127	1270	29474085
Neutropenia	63.81	10.68	227	98945	131484	29343871
Hyperkalaemia	63.75	10.68	67	99105	61325	29414030
Cardiac failure	63.45	10.68	105	99067	79182	29396173
Tremor	63.31	10.68	443	98729	73095	29402260
Psychomotor hyperactivity	63.09	10.68	105	99067	8108	29467247
Irritability	62.79	10.68	190	98982	21962	29453393
Bradypnoea	61.28	10.68	56	99116	2315	29473040
Thinking abnormal	60.42	10.68	81	99091	5155	29470200
Gastrointestinal haemorrhage	60.29	10.68	109	99063	79424	29395931
Disturbance in attention	60.01	10.68	183	98989	21241	29454114
Hallucination, auditory	59.92	10.68	112	99060	9481	29465874
Renal impairment	59.42	10.68	114	99058	81219	29394136
Anger	59.32	10.68	120	99052	10770	29464585
Stoma site discharge	58.12	10.68	37	99135	880	29474475
Pleural effusion	57.75	10.68	95	99077	71813	29403542
Tearfulness	57.31	10.68	46	99126	1590	29473765
Akathisia	56.97	10.68	90	99082	6652	29468703
Generalised tonic-clonic seizure	56.94	10.68	167	99005	18972	29456383
Epilepsy	56.92	10.68	163	99009	18269	29457086
Confusional state	56.32	10.68	666	98506	127211	29348144
Memory impairment	56.25	10.68	257	98915	36213	29439142
General physical health deterioration	55.50	10.68	169	99003	102688	29372667
Mental impairment	54.96	10.68	105	99067	9036	29466319
Gait disturbance	54.11	10.68	426	98746	72923	29402432
Drug use disorder	54.08	10.68	62	99110	3360	29471995
Cognitive disorder	53.47	10.68	187	98985	23312	29452043
Stomatitis	53.26	10.68	29	99143	37084	29438271
Catatonia	52.91	10.68	70	99102	4398	29470957
Device interaction	52.50	10.68	29	99143	526	29474829
Dysarthria	52.34	10.68	224	98948	30687	29444668
Posture abnormal	52.31	10.68	47	99125	1900	29473455
Joint swelling	51.71	10.68	54	99118	49576	29425779
Drooling	51.61	10.68	57	99115	2964	29472391
Tardive dyskinesia	51.23	10.68	75	99097	5183	29470172
Cardiac failure congestive	51.14	10.68	113	99059	76468	29398887
Disorientation	50.84	10.68	215	98957	29300	29446055
Nervousness	49.45	10.68	114	99058	11192	29464163
Withdrawal syndrome	48.26	10.68	111	99061	10881	29464474
Middle insomnia	47.96	10.68	76	99096	5632	29469723
Prescribed overdose	47.67	10.68	96	99076	8587	29466768
Haemoglobin decreased	46.54	10.68	196	98976	108179	29367176
Behaviour disorder	46.49	10.68	59	99113	3557	29471798
Housebound	45.72	10.68	20	99152	212	29475143
Schizophrenia	45.26	10.68	80	99092	6485	29468870
Depressive symptom	45.25	10.68	41	99131	1676	29473679
Myoclonic epilepsy	44.27	10.68	32	99140	943	29474412
Infusion related reaction	43.23	10.68	50	99122	43836	29431519
Drug abuser	42.33	10.68	58	99114	3769	29471586
Ascites	41.45	10.68	37	99135	36582	29438773
Respiratory depression	41.18	10.68	119	99053	13404	29461951
Acute myocardial infarction	40.77	10.68	62	99110	48376	29426979
Device dislocation	40.43	10.68	62	99110	4465	29470890
Cytomegalovirus infection	39.85	10.68	14	99158	23201	29452154
Oedema peripheral	39.85	10.68	195	98977	103362	29371993
Cerebrovascular accident	39.62	10.68	129	99043	76782	29398573
Urticaria	39.57	10.68	77	99095	54583	29420772
Psychomotor retardation	38.96	10.68	49	99123	2927	29472428
Hyperprolactinaemia	38.83	10.68	33	99139	1237	29474118
Dyspnoea exertional	38.80	10.68	39	99133	36451	29438904
Mental disorder	38.76	10.68	113	99059	12792	29462563
Stoma site erythema	38.75	10.68	25	99147	609	29474746
Abnormal dreams	38.58	10.68	77	99095	6843	29468512
Mucosal inflammation	38.12	10.68	30	99142	31565	29443790
Cerebral haemorrhage	37.72	10.68	30	99142	31396	29443959
Blood creatinine increased	37.72	10.68	152	99020	84950	29390405
Loss of consciousness	37.71	10.68	397	98775	73659	29401696
Myoclonus	37.56	10.68	114	99058	13195	29462160
Unresponsive to stimuli	37.21	10.68	175	98997	24951	29450404
Bone marrow failure	37.17	10.68	23	99149	27426	29447929
Fall	36.99	10.68	815	98357	176363	29298992
Contraindicated product administered	36.98	10.68	8	99164	18258	29457097
Drug hypersensitivity	36.45	10.68	113	99059	68293	29407062
Hallucination, visual	36.35	10.68	122	99050	14893	29460462
Lactic acidosis	36.14	10.68	29	99143	30218	29445137
Dystonic tremor	35.66	10.68	16	99156	181	29475174
Agoraphobia	35.53	10.68	17	99155	225	29475130
Drug ineffective	35.42	10.68	1521	97651	361649	29113706
Nausea	35.41	10.68	721	98451	288534	29186821
Infection	35.34	10.68	135	99037	76616	29398739
Drug diversion	35.31	10.68	26	99146	789	29474566
Angioedema	35.22	10.68	33	99139	31882	29443473
Decreased appetite	35.04	10.68	315	98857	145027	29330328
Toxicologic test abnormal	35.02	10.68	22	99150	511	29474844
Screaming	34.80	10.68	31	99141	1239	29474116
Accidental death	34.53	10.68	39	99133	2079	29473276
Mania	34.26	10.68	84	99088	8579	29466776
Blood creatine phosphokinase increased	33.87	10.68	243	98929	40401	29434954
Melaena	33.52	10.68	33	99139	31143	29444212
Movement disorder	33.04	10.68	92	99080	10145	29465210
Encephalitis toxic	32.78	10.68	17	99155	270	29475085
Pneumocystis jirovecii pneumonia	32.67	10.68	8	99164	16771	29458584
Disinhibition	32.67	10.68	42	99130	2565	29472790
Colitis	32.54	10.68	34	99138	31214	29444141
Hypertonia	32.19	10.68	51	99121	3778	29471577
Product substitution issue	32.18	10.68	85	99087	9087	29466268
Septic shock	32.17	10.68	105	99067	62455	29412900
Psychogenic seizure	31.94	10.68	18	99154	340	29475015
Medication error	31.60	10.68	148	99024	21063	29454292
Electroencephalogram abnormal	31.45	10.68	39	99133	2296	29473059
Arthralgia	31.33	10.68	308	98864	139309	29336046
Drug screen positive	31.09	10.68	50	99122	3751	29471604
Erythema	31.06	10.68	139	99033	75467	29399888
Withdrawal arrhythmia	31.05	10.68	10	99162	40	29475315
Freezing phenomenon	31.03	10.68	29	99143	1234	29474121
Obsessive-compulsive disorder	30.56	10.68	55	99117	4521	29470834
Pruritus	30.50	10.68	248	98924	116601	29358754
Coronary artery disease	30.49	10.68	64	99108	44126	29431229
Feeling of despair	30.35	10.68	25	99147	897	29474458
Postmortem blood drug level increased	30.23	10.68	15	99157	216	29475139
Myelodysplastic syndrome	30.08	10.68	11	99161	17783	29457572
Brain scan abnormal	29.99	10.68	24	99148	826	29474529
Cough	29.95	10.68	276	98896	126451	29348904
Anaphylactic reaction	29.86	10.68	29	99143	27544	29447811
Haematochezia	29.54	10.68	49	99123	36934	29438421
Postmortem blood drug level abnormal	29.53	10.68	16	99156	279	29475076
Poor quality sleep	29.53	10.68	71	99101	7162	29468193
Neuropathy peripheral	29.52	10.68	130	99042	70897	29404458
COVID-19	29.44	10.68	47	99125	35967	29439388
Crying	29.18	10.68	59	99113	5292	29470063
Multiple organ dysfunction syndrome	29.06	10.68	111	99061	63005	29412350
Drug screen negative	29.05	10.68	13	99159	146	29475209
Multiple-drug resistance	28.81	10.68	49	99123	3851	29471504
Haematuria	28.74	10.68	66	99106	44073	29431282
Feeling abnormal	28.71	10.68	294	98878	54151	29421204
Drug intolerance	28.64	10.68	76	99096	48303	29427052
Accidental overdose	28.63	10.68	126	99046	17467	29457888
Cerebral artery thrombosis	28.44	10.68	22	99150	720	29474635
Vessel puncture site erythema	28.21	10.68	6	99166	0	29475355
Illness anxiety disorder	28.15	10.68	13	99159	158	29475197
Bronchopulmonary aspergillosis	28.05	10.68	4	99168	12340	29463015
Proteinuria	28.05	10.68	9	99163	15795	29459560
Bipolar disorder	27.86	10.68	44	99128	3251	29472104
Meconium aspiration syndrome	27.38	10.68	9	99163	39	29475316
Atonic seizures	26.97	10.68	13	99159	175	29475180
Red cell distribution width decreased	26.71	10.68	13	99159	179	29475176
Dysphoria	26.68	10.68	34	99138	2058	29473297
Cerebral infarction	26.66	10.68	26	99146	24649	29450706
Torticollis	26.63	10.68	25	99147	1070	29474285
Anticonvulsant drug level above therapeutic	26.43	10.68	19	99153	555	29474800
Rheumatoid arthritis	26.24	10.68	42	99130	32110	29443245
Plasma cell myeloma	26.24	10.68	53	99119	37062	29438293
Neutropenic sepsis	26.19	10.68	4	99168	11723	29463632
Choreoathetosis	26.18	10.68	24	99148	996	29474359
Purpura fulminans	26.09	10.68	10	99162	73	29475282
Coordination abnormal	26.06	10.68	67	99105	7047	29468308
Hypothermia	25.94	10.68	79	99093	9160	29466195
Drug tolerance	25.91	10.68	34	99138	2119	29473236
Restless legs syndrome	25.81	10.68	66	99106	6918	29468437
Amnesia	25.41	10.68	146	99026	22497	29452858
Failure to suspend medication	25.30	10.68	16	99156	376	29474979
International normalised ratio increased	25.29	10.68	71	99101	44301	29431054
Gastrointestinal hypermotility	25.03	10.68	11	99161	118	29475237
Substance use disorder	24.86	10.68	14	99158	264	29475091
Hyperammonaemia	24.65	10.68	57	99115	5606	29469749
Brain injury	24.57	10.68	56	99116	5456	29469899
Electrocardiogram QRS complex prolonged	24.45	10.68	47	99125	4063	29471292
Talipes	24.25	10.68	30	99142	1762	29473593
Sleep apnoea syndrome	24.20	10.68	120	99052	17479	29457876
Cytokine release syndrome	24.13	10.68	7	99165	13112	29462243
Pulmonary fibrosis	24.12	10.68	11	99161	15571	29459784
Generalised anxiety disorder	24.04	10.68	19	99153	642	29474713
Balance disorder	23.92	10.68	205	98967	35965	29439390
Drug level above therapeutic	23.68	10.68	41	99131	3269	29472086
Acute myeloid leukaemia	23.54	10.68	13	99159	16500	29458855
Myelosuppression	23.48	10.68	6	99166	12221	29463134
Blunted affect	23.36	10.68	14	99158	298	29475057
Delirium	23.34	10.68	218	98954	39179	29436176
Blood creatine phosphokinase	23.33	10.68	9	99163	67	29475288
Multiple sclerosis	23.19	10.68	55	99117	5499	29469856
Basal cell carcinoma	23.13	10.68	14	99158	16896	29458459
Panic disorder	23.05	10.68	24	99148	1166	29474189
Feeling guilty	23.03	10.68	14	99158	306	29475049
Thrombosis	22.99	10.68	71	99101	42974	29432381
Haemorrhage	22.92	10.68	76	99096	44996	29430359
Aspergillus infection	22.76	10.68	4	99168	10577	29464778
Blood bilirubin increased	22.62	10.68	50	99122	33843	29441512
Dysmetria	22.49	10.68	15	99157	387	29474968
Gambling disorder	22.34	10.68	27	99145	1548	29473807
Tubulointerstitial nephritis	22.25	10.68	16	99156	17627	29457728
Hypotonia	22.25	10.68	62	99110	6840	29468515
Cogwheel rigidity	22.18	10.68	24	99148	1219	29474136
Asthenia	22.17	10.68	551	98621	214699	29260656
Arthritis	22.05	10.68	31	99141	24988	29450367
Intensive care unit acquired weakness	21.92	10.68	21	99151	922	29474433
Nightmare	21.90	10.68	86	99086	11331	29464024
Muscle contracture	21.88	10.68	23	99149	1130	29474225
Treatment failure	21.88	10.68	58	99114	36881	29438474
Somnambulism	21.79	10.68	36	99136	2762	29472593
Dehydration	21.78	10.68	263	98909	114485	29360870
Bacteraemia	21.66	10.68	14	99158	16309	29459046
Tachyphrenia	21.62	10.68	23	99149	1146	29474209
Affect lability	21.60	10.68	40	99132	3362	29471993
Pulmonary embolism	21.56	10.68	159	99013	76375	29398980
Exposure via ingestion	21.44	10.68	30	99142	1988	29473367
Vomiting	21.41	10.68	545	98627	211715	29263640
Epistaxis	21.26	10.68	95	99077	51609	29423746
Physical assault	21.25	10.68	22	99150	1062	29474293
Parasomnia	21.20	10.68	14	99158	355	29475000
Tension	21.17	10.68	29	99143	1884	29473471
Depressed mood	21.11	10.68	110	99062	16338	29459017
Injection site exfoliation	21.03	10.68	6	99166	14	29475341
Excessive eye blinking	20.96	10.68	15	99157	435	29474920
Reduced facial expression	20.88	10.68	18	99154	688	29474667
Congenital melanocytic naevus	20.74	10.68	6	99166	15	29475340
Personality disorder	20.60	10.68	22	99150	1101	29474254
Hypomagnesaemia	20.55	10.68	17	99155	17451	29457904
Palmar-plantar erythrodysaesthesia syndrome	20.50	10.68	12	99160	14747	29460608
Ehlers-Danlos syndrome	20.48	10.68	7	99165	35	29475320
Antidepressant drug level increased	20.44	10.68	9	99163	97	29475258
Obsessive-compulsive personality disorder	20.21	10.68	10	99162	143	29475212
Posterior reversible encephalopathy syndrome	20.19	10.68	3	99169	8973	29466382
Partial seizures	20.06	10.68	42	99130	3861	29471494
Stoma site extravasation	19.93	10.68	8	99164	67	29475288
Stereotypy	19.90	10.68	17	99155	642	29474713
Laboratory test abnormal	19.83	10.68	19	99153	18166	29457189
Blood prolactin increased	19.67	10.68	25	99147	1509	29473846
Osteonecrosis of jaw	19.51	10.68	16	99156	16494	29458861
Injection site dryness	19.48	10.68	6	99166	20	29475335
Hyperchloraemia	19.47	10.68	14	99158	409	29474946
Phaeochromocytoma malignant	19.43	10.68	8	99164	72	29475283
Haematemesis	19.32	10.68	33	99139	24593	29450762
Nephropathy toxic	19.31	10.68	6	99166	10750	29464605
Thrombotic microangiopathy	19.30	10.68	3	99169	8678	29466677
Stoma site inflammation	19.18	10.68	14	99158	419	29474936
Language disorder	19.17	10.68	28	99144	1931	29473424
Hepatotoxicity	19.10	10.68	19	99153	17848	29457507
Hypokalaemia	19.02	10.68	95	99077	50108	29425247
Spasmodic dysphonia	18.96	10.68	8	99164	77	29475278
Stoma site infection	18.95	10.68	17	99155	686	29474669
Weight increased	18.69	10.68	361	98811	76306	29399049
Persecutory delusion	18.67	10.68	29	99143	2112	29473243
Angina pectoris	18.65	10.68	41	99131	27809	29447546
Cytopenia	18.62	10.68	5	99167	9854	29465501
Postictal paralysis	18.44	10.68	11	99161	232	29475123
Rapid eye movement sleep behaviour disorder	18.42	10.68	9	99163	125	29475230
Areflexia	18.26	10.68	33	99139	2721	29472634
Peripheral swelling	18.15	10.68	132	99040	63607	29411748
Gaze palsy	17.99	10.68	22	99150	1277	29474078
Hypertension	17.91	10.68	279	98893	116335	29359020
Chills	17.83	10.68	153	99019	71147	29404208
Developmental delay	17.76	10.68	31	99141	2487	29472868
Shock haemorrhagic	17.75	10.68	5	99167	9546	29465809
Autonomic nervous system imbalance	17.75	10.68	30	99142	2346	29473009
Cluster headache	17.74	10.68	14	99158	472	29474883
Physical abuse	17.73	10.68	5	99167	11	29475344
Liver disorder	17.65	10.68	42	99130	27707	29447648
Postmortem blood drug level	17.64	10.68	9	99163	138	29475217
HIV peripheral neuropathy	17.56	10.68	6	99166	30	29475325
Myalgia	17.56	10.68	161	99011	73858	29401497
Apathy	17.54	10.68	53	99119	6118	29469237
Upper gastrointestinal haemorrhage	17.53	10.68	29	99143	21885	29453470
Terminal insomnia	17.53	10.68	13	99159	399	29474956
Electrocardiogram QT shortened	17.52	10.68	9	99163	140	29475215
Drug ineffective for unapproved indication	17.51	10.68	94	99078	14120	29461235
Oedema	17.49	10.68	73	99099	40410	29434945
Hypersomnia	17.48	10.68	77	99095	10677	29464678
Neoplasm progression	17.48	10.68	22	99150	18590	29456765
Postoperative respiratory failure	17.41	10.68	8	99164	96	29475259
Wrong patient received product	17.29	10.68	29	99143	2253	29473102
Extrapyramidal disorder	17.19	10.68	77	99095	10754	29464601
Major depression	17.13	10.68	39	99133	3796	29471559
Post-traumatic stress disorder	17.07	10.68	24	99148	1598	29473757
Hepatic cirrhosis	17.07	10.68	14	99158	14430	29460925
Tumour lysis syndrome	16.98	10.68	13	99159	13871	29461484
Hypomania	16.96	10.68	28	99144	2147	29473208
Antipsychotic drug level increased	16.79	10.68	35	99137	3208	29472147
Prostate cancer	16.75	10.68	38	99134	25489	29449866
Opsoclonus myoclonus	16.72	10.68	7	99165	66	29475289
Developmental regression	16.65	10.68	6	99166	36	29475319
Sedation complication	16.61	10.68	21	99151	1261	29474094
Homicidal ideation	16.43	10.68	30	99142	2494	29472861
Poverty of speech	16.32	10.68	10	99162	222	29475133
Patient uncooperative	16.30	10.68	12	99160	364	29474991
Renal hypertension	16.26	10.68	9	99163	164	29475191
Graft versus host disease	16.19	10.68	6	99166	9622	29465733
Priapism	16.16	10.68	42	99130	4446	29470909
Haemorrhage intracranial	16.09	10.68	15	99157	14527	29460828
Parkinsonian gait	16.06	10.68	13	99159	455	29474900
Change in seizure presentation	16.02	10.68	7	99165	74	29475281
Bruxism	15.99	10.68	23	99149	1564	29473791
Blood bicarbonate decreased	15.98	10.68	28	99144	2254	29473101
Asterixis	15.90	10.68	19	99153	1076	29474279
COVID-19 pneumonia	15.90	10.68	6	99166	9516	29465839
Cholangitis	15.88	10.68	3	99169	7534	29467821
Lymphadenopathy	15.87	10.68	38	99134	25011	29450344
Squamous cell carcinoma of skin	15.81	10.68	6	99166	9480	29465875
Galactorrhoea	15.80	10.68	12	99160	382	29474973
Herpes zoster	15.74	10.68	50	99122	30002	29445353
Depersonalisation/derealisation disorder	15.56	10.68	14	99158	567	29474788
Infantile spasms	15.51	10.68	9	99163	180	29475175
Clonic convulsion	15.48	10.68	14	99158	571	29474784
Dopamine dysregulation syndrome	15.40	10.68	11	99161	318	29475037
Haemophagocytic lymphohistiocytosis	15.37	10.68	8	99164	10496	29464859
Heat stroke	15.27	10.68	17	99155	892	29474463
Feeling jittery	15.19	10.68	36	99136	3597	29471758
Brain oedema	15.18	10.68	81	99091	12139	29463216
Impulsive behaviour	15.14	10.68	25	99147	1918	29473437
Muscle twitching	15.02	10.68	60	99112	7966	29467389
Intelligence test abnormal	14.97	10.68	5	99167	23	29475332
Hyperthermia	14.94	10.68	67	99105	9363	29465992
Psychiatric symptom	14.92	10.68	33	99139	3151	29472204
Allodynia	14.92	10.68	14	99158	599	29474756
Chronic kidney disease	14.91	10.68	67	99105	36349	29439006
Muscle spasticity	14.89	10.68	43	99129	4840	29470515
Petit mal epilepsy	14.83	10.68	30	99142	2692	29472663
Pseudomonas infection	14.82	10.68	9	99163	10843	29464512
Libido increased	14.80	10.68	15	99157	706	29474649
Eye movement disorder	14.78	10.68	36	99136	3660	29471695
Stupor	14.66	10.68	30	99142	2714	29472641
Panic reaction	14.65	10.68	20	99152	1295	29474060
Bradycardia	14.65	10.68	305	98867	65324	29410031
Atrial flutter	14.60	10.68	15	99157	13879	29461476
Pneumothorax	14.59	10.68	19	99153	15823	29459532
Myocarditis	14.56	10.68	74	99098	10882	29464473
Cholestasis	14.54	10.68	36	99136	23426	29451929
Pulmonary hypertension	14.54	10.68	25	99147	18583	29456772
Psychotic behaviour	14.51	10.68	14	99158	620	29474735
Mental status changes	14.50	10.68	180	98992	34747	29440608
Rectal haemorrhage	14.49	10.68	63	99109	34486	29440869
Wrong schedule	14.49	10.68	8	99164	145	29475210
Substance dependence	14.46	10.68	11	99161	351	29475004
Sleep-related eating disorder	14.40	10.68	10	99162	276	29475079
Clostridium difficile infection	14.22	10.68	20	99152	16121	29459234
Anhidrosis	14.22	10.68	7	99165	99	29475256
Accommodation disorder	14.18	10.68	9	99163	213	29475142
Staphylococcal sepsis	14.12	10.68	6	99166	8856	29466499
Adrenal insufficiency	14.12	10.68	10	99162	11104	29464251
Anal spasm	14.10	10.68	3	99169	0	29475355
Eustachian tube disorder	14.10	10.68	3	99169	0	29475355
Suicidal behaviour	14.07	10.68	20	99152	1345	29474010
Stoma site hypergranulation	14.06	10.68	8	99164	154	29475201
Lethargy	14.05	10.68	190	98982	37390	29437965
Hyperphagia	14.03	10.68	19	99153	1221	29474134
Gout	13.88	10.68	22	99150	16889	29458466
Sexual dysfunction	13.86	10.68	47	99125	5767	29469588
Therapy non-responder	13.81	10.68	55	99117	30856	29444499
Syncope	13.77	10.68	191	98981	81180	29394175
Hyperosmolar state	13.76	10.68	11	99161	378	29474977
Frustration tolerance decreased	13.70	10.68	26	99146	2226	29473129
Off label use	13.67	10.68	848	98324	299952	29175403
Urinary tract discomfort	13.62	10.68	7	99165	109	29475246
Drug level decreased	13.59	10.68	49	99123	6198	29469157
Purpura	13.55	10.68	7	99165	9225	29466130
Deep vein thrombosis	13.54	10.68	125	99047	57274	29418081
Embedded device	13.54	10.68	9	99163	231	29475124
Dependence	13.48	10.68	17	99155	1018	29474337
Erectile dysfunction	13.48	10.68	105	99067	17904	29457451
Logorrhoea	13.41	10.68	26	99146	2262	29473093
Myositis	13.40	10.68	9	99163	10274	29465081
Ammonia abnormal	13.36	10.68	6	99166	68	29475287
Rash pruritic	13.33	10.68	35	99137	22328	29453027
Compartment syndrome	13.33	10.68	27	99145	2425	29472930
Treatment noncompliance	13.33	10.68	132	99040	24095	29451260
Monorchidism	13.30	10.68	4	99168	12	29475343
Medical device site dryness	13.30	10.68	4	99168	12	29475343
Locomotive syndrome	13.30	10.68	4	99168	12	29475343
Death	13.27	10.68	978	98194	341106	29134249
Hostility	13.24	10.68	15	99157	802	29474553
Blepharospasm	13.22	10.68	17	99155	1038	29474317
Drug level increased	13.22	10.68	108	99064	18679	29456676
Nystagmus	13.20	10.68	38	99134	4271	29471084
Brain malformation	13.18	10.68	7	99165	117	29475238
Product complaint	13.15	10.68	44	99128	5361	29469994
Staphylococcal infection	13.08	10.68	52	99120	29188	29446167
Niemann-Pick disease	13.06	10.68	4	99168	13	29475342
Tooth injury	13.05	10.68	15	99157	815	29474540
Sleep disorder	12.99	10.68	132	99040	24254	29451101
Fibroma	12.98	10.68	9	99163	248	29475107
Self esteem decreased	12.95	10.68	12	99160	505	29474850
Tuberculosis	12.94	10.68	4	99168	7192	29468163
Road traffic accident	12.93	10.68	93	99079	15468	29459887
Haematuria traumatic	12.92	10.68	8	99164	181	29475174
Labelled drug-drug interaction medication error	12.92	10.68	13	99159	12146	29463209
Stoma site pain	12.91	10.68	12	99160	507	29474848
Nasal septum deviation	12.89	10.68	16	99156	943	29474412
Glossopharyngeal nerve disorder	12.88	10.68	5	99167	38	29475317
Obsessive thoughts	12.87	10.68	13	99159	609	29474746
Confusional arousal	12.84	10.68	4	99168	14	29475341
Communication disorder	12.80	10.68	26	99146	2339	29473016
Ejaculation disorder	12.77	10.68	16	99156	952	29474403
Lennox-Gastaut syndrome	12.76	10.68	5	99167	39	29475316
Cardiac failure chronic	12.75	10.68	3	99169	6464	29468891
Diverticulitis	12.75	10.68	25	99147	17679	29457676
Fatigue	12.73	10.68	903	98269	315918	29159437
Swelling	12.67	10.68	68	99104	35215	29440140
Bipolar I disorder	12.63	10.68	14	99158	731	29474624
Congenital cerebral cyst	12.62	10.68	4	99168	15	29475340
Staphylococcal bacteraemia	12.62	10.68	4	99168	7075	29468280
Dementia with Lewy bodies	12.60	10.68	13	99159	625	29474730
Tachycardia	12.60	10.68	325	98847	72085	29403270
Oesophageal food impaction	12.50	10.68	6	99166	80	29475275
Inflammation	12.48	10.68	37	99135	22691	29452664
Fluid retention	12.48	10.68	39	99133	23521	29451834
Senile dementia	12.44	10.68	5	99167	42	29475313
Mumps	12.43	10.68	6	99166	81	29475274
Inappropriate affect	12.41	10.68	12	99160	533	29474822
Hyperglycaemia	12.35	10.68	66	99106	34221	29441134
Gallbladder polyp	12.35	10.68	10	99162	350	29475005
Blood osmolarity decreased	12.34	10.68	12	99160	537	29474818
Urinary incontinence	12.29	10.68	96	99076	16385	29458970
Weight abnormal	12.28	10.68	11	99161	443	29474912
Abdominal pain	12.20	10.68	353	98819	135004	29340351
Social avoidant behaviour	12.14	10.68	29	99143	2913	29472442
Akinesia	12.14	10.68	23	99149	1967	29473388
Pseudodementia	12.03	10.68	3	99169	3	29475352
Medical device site scab	12.03	10.68	3	99169	3	29475352
Neurosis	12.02	10.68	7	99165	141	29475214
Developmental hip dysplasia	11.97	10.68	9	99163	282	29475073
Jaundice	11.93	10.68	54	99118	29242	29446113
Hypothermia neonatal	11.93	10.68	6	99166	89	29475266
Oropharyngeal pain	11.92	10.68	54	99118	29231	29446124
Arthropathy	11.90	10.68	35	99137	21519	29453836
Rabbit syndrome	11.87	10.68	4	99168	19	29475336
Type 2 diabetes mellitus	11.77	10.68	82	99090	13499	29461856
Multiple sclerosis relapse	11.76	10.68	72	99100	11347	29464008
Lymphopenia	11.69	10.68	17	99155	13516	29461839
Hyperkinesia	11.69	10.68	20	99152	1579	29473776
Diet refusal	11.60	10.68	9	99163	296	29475059
Clonus	11.54	10.68	25	99147	2353	29473002
Personality change	11.50	10.68	38	99134	4600	29470755
Somatic delusion	11.48	10.68	6	99166	97	29475258
Epstein-Barr virus infection	11.37	10.68	4	99168	6625	29468730
Libido decreased	11.37	10.68	36	99136	4262	29471093
Disseminated intravascular coagulation	11.36	10.68	32	99140	19948	29455407
Low birth weight baby	11.31	10.68	4	99168	6604	29468751
Swelling face	11.27	10.68	33	99139	20317	29455038
Bulbar palsy	11.21	10.68	8	99164	231	29475124
Hallucinations, mixed	11.16	10.68	25	99147	2408	29472947
Acute coronary syndrome	11.13	10.68	15	99157	12310	29463045
Feeling drunk	11.11	10.68	20	99152	1644	29473711
Pneumonia bacterial	11.11	10.68	9	99163	9334	29466021
Dissociative identity disorder	11.10	10.68	4	99168	24	29475331
Hypocalcaemia	11.09	10.68	34	99138	20631	29454724
Sleep paralysis	11.09	10.68	7	99165	164	29475191
Hyperhidrosis	11.03	10.68	289	98883	64251	29411104
Suspected suicide	10.94	10.68	34	99138	3986	29471369
Face oedema	10.92	10.68	11	99161	10272	29465083
Intraventricular haemorrhage neonatal	10.89	10.68	8	99164	242	29475113
Ammonia increased	10.88	10.68	34	99138	3997	29471358
Poisoning deliberate	10.85	10.68	43	99129	5688	29469667
Hemiparesis	10.83	10.68	20	99152	14466	29460889
Sinus tachycardia	10.81	10.68	87	99085	14982	29460373
Irregular sleep phase	10.74	10.68	5	99167	62	29475293
Renal injury	10.73	10.68	11	99161	10191	29465164

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	3162.30	9.77	3913	222943	220501	64051375
Drug abuse	1559.20	9.77	2116	224740	130258	64141618
Toxicity to various agents	1383.96	9.77	3568	223288	359945	63911931
Respiratory arrest	807.95	9.77	964	225892	52021	64219855
Depression	654.03	9.77	1759	225097	181532	64090344
Suicide attempt	652.25	9.77	1010	225846	69997	64201879
Intentional overdose	586.04	9.77	1098	225758	88846	64183030
Cardio-respiratory arrest	584.54	9.77	1155	225701	97238	64174638
Somnolence	578.48	9.77	1801	225055	201844	64070032
Sopor	570.35	9.77	609	226247	29052	64242824
Overdose	563.71	9.77	1526	225330	158040	64113836
Suicidal ideation	435.40	9.77	814	226042	65728	64206148
Cardiac arrest	432.06	9.77	1357	225499	152707	64119169
Poisoning	411.42	9.77	444	226412	21435	64250441
Psychotic disorder	372.14	9.77	530	226326	34048	64237828
Drug withdrawal syndrome	359.65	9.77	495	226361	30796	64241080
Seizure	355.13	9.77	1341	225515	165551	64106325
Neuroleptic malignant syndrome	343.94	9.77	432	226424	24564	64247312
Anxiety	325.03	9.77	1493	225363	201156	64070720
Intentional self-injury	316.70	9.77	448	226408	28596	64243280
Drug dependence	311.53	9.77	478	226378	32834	64239042
Synovitis	310.58	9.77	8	226848	99082	64172794
Agitation	301.61	9.77	835	226021	87532	64184344
Acute kidney injury	298.19	9.77	717	226139	448523	63823353
Intentional product misuse	288.33	9.77	724	226132	71571	64200305
Febrile neutropenia	283.94	9.77	153	226703	187504	64084372
Aggression	275.87	9.77	544	226312	45688	64226188
Contraindicated product administered	270.89	9.77	31	226825	107798	64164078
Drug interaction	261.25	9.77	2169	224687	359914	63911962
Anaemia	245.92	9.77	611	226245	378069	63893807
Coma	243.77	9.77	770	226086	86845	64185031
Abnormal behaviour	235.86	9.77	424	226432	33198	64238678
Depressed level of consciousness	216.82	9.77	705	226151	80731	64191145
Schizophrenia	208.82	9.77	226	226630	10942	64260934
Tremor	205.69	9.77	1048	225808	147182	64124694
Infusion related reaction	205.61	9.77	166	226690	164301	64107575
Drug intolerance	197.35	9.77	222	226634	187770	64084106
Dyskinesia	191.25	9.77	426	226430	38962	64232914
Panic attack	189.37	9.77	296	226560	20657	64251219
Sedation	187.52	9.77	436	226420	41026	64230850
Speech disorder	186.72	9.77	479	226377	47962	64223914
Insomnia	184.67	9.77	1260	225596	196576	64075300
Joint swelling	182.92	9.77	297	226559	215085	64056791
Stubbornness	181.38	9.77	60	226796	251	64271625
Irritability	180.18	9.77	399	226457	36347	64235529
Ataxia	179.12	9.77	297	226559	21787	64250089
Rash	174.06	9.77	926	225930	457623	63814253
Miosis	169.45	9.77	221	226635	13045	64258831
Rheumatoid arthritis	164.91	9.77	201	226655	164093	64107783
Thrombocytopenia	162.18	9.77	340	226516	223461	64048415
Drug withdrawal convulsions	161.57	9.77	98	226758	2030	64269846
Serotonin syndrome	161.40	9.77	398	226458	38884	64232992
Hand deformity	160.28	9.77	17	226839	62754	64209122
Thinking abnormal	153.05	9.77	196	226660	11360	64260516
Paranoia	150.55	9.77	233	226623	16119	64255757
Sepsis	149.82	9.77	371	226485	229970	64041906
Pancytopenia	149.53	9.77	170	226686	143139	64128737
Drug hypersensitivity	149.31	9.77	390	226466	237425	64034451
Neutropenia	146.63	9.77	398	226458	239226	64032650
Atrial fibrillation	143.29	9.77	238	226618	170851	64101025
Substance abuse	143.05	9.77	170	226686	9122	64262754
Unresponsive to stimuli	142.97	9.77	446	226410	49947	64221929
General physical health deterioration	142.75	9.77	317	226539	204108	64067768
Dystonia	140.16	9.77	244	226612	18621	64253255
Systemic lupus erythematosus	139.93	9.77	49	226807	77563	64194313
Mydriasis	139.32	9.77	217	226639	15095	64256781
Diarrhoea	139.28	9.77	1752	225104	720952	63550924
Interstitial lung disease	138.73	9.77	86	226770	97646	64174230
Dyspnoea	138.20	9.77	1743	225113	716931	63554945
Muscle rigidity	133.74	9.77	229	226627	17244	64254632
Treatment failure	132.60	9.77	129	226727	116687	64155189
Pericarditis	132.22	9.77	29	226827	62487	64209389
Withdrawal syndrome	128.87	9.77	267	226589	23225	64248651
Malignant neoplasm progression	128.87	9.77	124	226732	112747	64159129
Tardive dyskinesia	128.43	9.77	160	226696	9018	64262858
Bradyphrenia	125.30	9.77	160	226696	9246	64262630
Arthropathy	124.56	9.77	145	226711	120822	64151054
Granulocytopenia	124.23	9.77	168	226688	10272	64261604
Mental disorder	122.77	9.77	281	226575	26164	64245712
Stomatitis	122.15	9.77	123	226733	109482	64162394
Hallucination	120.72	9.77	542	226314	72246	64199630
Disturbance in attention	120.67	9.77	368	226488	40706	64231170
Restless legs syndrome	120.22	9.77	216	226640	16900	64254976
Status epilepticus	119.76	9.77	247	226609	21416	64250460
Feeling of despair	116.85	9.77	86	226770	2482	64269394
Disease progression	116.85	9.77	199	226657	141481	64130395
Restlessness	115.53	9.77	355	226501	39430	64232446
Infection	115.38	9.77	304	226552	184576	64087300
Mania	114.99	9.77	206	226650	16080	64255796
Hypersensitivity	114.45	9.77	334	226522	196118	64075758
Drooling	112.57	9.77	115	226741	5204	64266672
Bradykinesia	111.00	9.77	126	226730	6434	64265442
Glossodynia	108.08	9.77	46	226810	64650	64207226
Memory impairment	107.91	9.77	590	226266	85092	64186784
Helicobacter infection	107.25	9.77	7	226849	38355	64233521
Gastrointestinal haemorrhage	107.14	9.77	188	226668	132124	64139752
Pleural effusion	106.92	9.77	175	226681	126384	64145492
Parkinsonism	105.60	9.77	185	226671	14188	64257688
Renal impairment	104.72	9.77	197	226659	134820	64137056
Anger	103.42	9.77	193	226663	15548	64256328
Crying	102.85	9.77	222	226634	19868	64252008
Cardiac failure	102.79	9.77	193	226663	132180	64139696
Platelet count decreased	99.97	9.77	282	226574	167429	64104447
Hyperkalaemia	99.05	9.77	126	226730	101003	64170873
Akathisia	99.03	9.77	159	226697	11351	64260525
Rheumatoid factor positive	98.80	9.77	6	226850	34932	64236944
Generalised tonic-clonic seizure	97.98	9.77	336	226520	39521	64232355
Lactic acidosis	97.38	9.77	47	226809	61363	64210513
Swelling	96.53	9.77	268	226588	159950	64111926
Pneumonia aspiration	95.77	9.77	438	226418	58833	64213043
Alopecia	95.54	9.77	283	226573	165407	64106469
Hallucination, auditory	94.65	9.77	194	226662	16745	64255131
On and off phenomenon	94.07	9.77	75	226781	2444	64269432
Cogwheel rigidity	94.05	9.77	79	226777	2774	64269102
Altered state of consciousness	90.98	9.77	317	226539	37585	64234291
Respiratory depression	90.51	9.77	232	226624	23211	64248665
Dysarthria	89.39	9.77	430	226426	58976	64212900
Arthralgia	88.74	9.77	1062	225794	441198	63830678
Mood altered	86.93	9.77	181	226675	15798	64256078
Renal failure	85.32	9.77	339	226517	181349	64090527
Bone marrow failure	85.19	9.77	31	226825	47921	64223955
Middle insomnia	84.74	9.77	158	226698	12719	64259157
Myocardial infarction	83.97	9.77	300	226556	165521	64106355
Drug use disorder	83.84	9.77	105	226751	5949	64265927
Psychomotor hyperactivity	83.71	9.77	168	226688	14283	64257593
Multiple sclerosis	81.09	9.77	195	226661	18746	64253130
Mucosal inflammation	80.90	9.77	61	226795	62523	64209353
Gastric pH decreased	80.48	9.77	43	226813	692	64271184
Cardiac failure congestive	80.46	9.77	216	226640	130364	64141512
Loss of consciousness	79.57	9.77	835	226021	147530	64124346
Pyrexia	79.53	9.77	1435	225421	557209	63714667
Impaired healing	79.38	9.77	58	226798	60415	64211461
Blood creatinine increased	78.93	9.77	231	226625	135551	64136325
Psychiatric decompensation	78.73	9.77	67	226789	2396	64269480
Disorientation	78.23	9.77	396	226460	55432	64216444
Gait disturbance	77.86	9.77	937	225919	171218	64100658
Maternal exposure during pregnancy	77.83	9.77	136	226720	95748	64176128
Drug abuser	77.69	9.77	99	226757	5709	64266167
Nightmare	77.19	9.77	204	226652	20789	64251087
Victim of crime	76.71	9.77	35	226821	392	64271484
Delusion	75.56	9.77	184	226672	17830	64254046
Sensitisation	74.36	9.77	56	226800	1675	64270201
Feeling abnormal	74.05	9.77	757	226099	132845	64139031
Salivary hypersecretion	74.00	9.77	144	226712	11969	64259907
Hyperprolactinaemia	73.79	9.77	81	226775	3984	64267892
Catatonia	73.56	9.77	111	226745	7509	64264367
Cytomegalovirus infection	73.30	9.77	20	226836	37179	64234697
Wound	72.10	9.77	98	226758	76379	64195497
Balance disorder	72.02	9.77	524	226332	83402	64188474
Lower respiratory tract infection	71.64	9.77	140	226716	94474	64177402
Melaena	70.75	9.77	51	226805	53497	64218379
Derealisation	70.14	9.77	51	226805	1444	64270432
Peripheral swelling	69.69	9.77	440	226416	208713	64063163
Polycystic ovaries	69.66	9.77	59	226797	2096	64269780
Amnesia	69.48	9.77	345	226511	47924	64223952
Hypersomnia	67.88	9.77	187	226669	19530	64252346
Hyperhidrosis	67.42	9.77	704	226152	124216	64147660
Haemoglobin decreased	67.25	9.77	406	226450	194657	64077219
Dissociation	67.20	9.77	67	226789	2944	64268932
Stoma site discharge	66.95	9.77	52	226804	1630	64270246
Exposure via ingestion	66.27	9.77	84	226772	4818	64267058
Off label use	66.11	9.77	1708	225148	631098	63640778
Bipolar disorder	65.99	9.77	99	226757	6662	64265214
Abdominal discomfort	65.77	9.77	374	226482	181948	64089928
Epilepsy	64.31	9.77	261	226595	33270	64238606
Ejection fraction	62.91	9.77	45	226811	1241	64270635
Multiple sclerosis relapse	62.78	9.77	299	226557	40836	64231040
Emotional disorder	61.91	9.77	137	226719	12470	64259406
Septic shock	61.54	9.77	179	226677	105258	64166618
Folliculitis	61.51	9.77	15	226841	30062	64241814
Mood swings	61.46	9.77	167	226689	17301	64254575
Nervousness	60.67	9.77	235	226621	29321	64242555
Angioedema	60.55	9.77	77	226779	61744	64210132
Depersonalisation/derealisation disorder	59.48	9.77	48	226808	1592	64270284
Electroencephalogram abnormal	59.29	9.77	82	226774	5121	64266755
Muscle injury	58.52	9.77	11	226845	26426	64245450
Urticaria	57.09	9.77	295	226561	147022	64124854
Myelosuppression	57.04	9.77	8	226848	23822	64248054
Personality disorder	56.34	9.77	76	226780	4635	64267241
Pneumocystis jirovecii pneumonia	56.08	9.77	14	226842	27620	64244256
Anticonvulsant drug level above therapeutic	54.94	9.77	38	226818	992	64270884
Ascites	54.94	9.77	83	226773	61918	64209958
Movement disorder	54.53	9.77	186	226670	21814	64250062
Haematochezia	53.98	9.77	94	226762	66279	64205597
Feeling of body temperature change	53.56	9.77	75	226781	4739	64267137
Hepatic enzyme increased	53.34	9.77	255	226601	129688	64142188
Confusional state	53.32	9.77	1248	225608	259896	64011980
Herpes zoster	52.63	9.77	126	226730	79061	64192815
Anaphylactic reaction	51.63	9.77	102	226754	68562	64203314
Palmar-plantar erythrodysaesthesia syndrome	50.57	9.77	19	226837	28800	64243076
Drug screen positive	50.46	9.77	80	226776	5649	64266227
Neuropathy peripheral	50.38	9.77	227	226629	117298	64154578
Osteonecrosis of jaw	49.96	9.77	40	226816	39785	64232091
Therapeutic product effect decreased	49.93	9.77	222	226634	115129	64156747
Dopamine dysregulation syndrome	49.59	9.77	27	226829	452	64271424
Acute myocardial infarction	49.52	9.77	107	226749	69611	64202265
Feeling jittery	49.35	9.77	113	226743	10522	64261354
Pneumonia	49.31	9.77	1546	225310	558030	63713846
Transplant rejection	49.16	9.77	3	226853	17398	64254478
Mental status changes	49.13	9.77	376	226480	60786	64211090
Erythema	49.11	9.77	421	226435	186649	64085227
Myocardial stunning	48.85	9.77	20	226836	168	64271708
Neutrophil count decreased	48.06	9.77	127	226729	77069	64194807
Breast hyperplasia	47.91	9.77	18	226838	117	64271759
Tearfulness	47.87	9.77	70	226786	4603	64267273
Depression suicidal	47.87	9.77	51	226805	2424	64269452
Mental impairment	47.59	9.77	146	226710	16197	64255679
Psychomotor skills impaired	47.47	9.77	63	226793	3782	64268094
Behaviour disorder	47.40	9.77	68	226788	4394	64267482
Drug screen negative	47.18	9.77	22	226834	260	64271616
Blood creatine phosphokinase increased	47.04	9.77	360	226496	58198	64213678
Loss of personal independence in daily activities	46.76	9.77	424	226432	72030	64199846
Stoma site erythema	46.50	9.77	37	226819	1202	64270674
Galactorrhoea	46.46	9.77	57	226799	3162	64268714
Menstrual disorder	46.02	9.77	58	226798	3307	64268569
Tension	46.00	9.77	62	226794	3778	64268098
Upper gastrointestinal haemorrhage	45.94	9.77	34	226822	35186	64236690
Proteinuria	45.84	9.77	20	226836	27703	64244173
Abnormal dreams	45.82	9.77	108	226748	10248	64261628
Sleep-related eating disorder	45.68	9.77	29	226827	653	64271223
Colitis	45.12	9.77	86	226770	58588	64213288
Incontinence	45.03	9.77	118	226738	11963	64259913
Sleep disorder due to general medical condition, insomnia type	44.97	9.77	18	226838	26252	64245624
Neutropenic sepsis	44.94	9.77	13	226843	23259	64248617
Housebound	44.81	9.77	25	226831	440	64271436
Decorticate posture	44.73	9.77	22	226834	295	64271581
Pulmonary fibrosis	44.20	9.77	25	226831	29853	64242023
Psychomotor retardation	44.18	9.77	71	226785	5072	64266804
Dysphoria	43.90	9.77	65	226791	4323	64267553
Atonic seizures	43.85	9.77	28	226828	637	64271239
Hallucinations, mixed	43.30	9.77	77	226779	5975	64265901
Multiple-drug resistance	43.06	9.77	80	226776	6422	64265454
Cognitive disorder	42.78	9.77	336	226520	54751	64217125
Hypercalcaemia	42.72	9.77	29	226827	31387	64240489
Red blood cell sedimentation rate abnormal	42.71	9.77	4	226852	16302	64255574
Fall	42.58	9.77	1832	225024	414994	63856882
Hypertension	42.32	9.77	649	226207	258612	64013264
Nasopharyngitis	42.27	9.77	463	226393	195610	64076266
Hypoaesthesia oral	42.03	9.77	112	226744	11468	64260408
Cerebral haemorrhage	41.87	9.77	72	226784	51018	64220858
Myoclonus	41.59	9.77	187	226669	24931	64246945
Cytokine release syndrome	41.41	9.77	11	226845	20818	64251058
Depressed mood	41.06	9.77	266	226590	40746	64231130
Haematuria	40.35	9.77	96	226760	60375	64211501
Myocardial depression	40.35	9.77	24	226832	479	64271397
Autonomic nervous system imbalance	39.61	9.77	60	226796	4072	64267804
Prescribed overdose	39.58	9.77	159	226697	20172	64251704
Screaming	39.29	9.77	55	226801	3474	64268402
H1N1 influenza	39.15	9.77	44	226812	2222	64269654
Hypocalcaemia	38.85	9.77	54	226802	41699	64230177
Bradypnoea	38.67	9.77	67	226789	5092	64266784
Gastrointestinal disorder	38.61	9.77	173	226683	89536	64182340
Depressive symptom	38.53	9.77	62	226794	4434	64267442
Major depression	38.45	9.77	85	226771	7731	64264145
Hostility	38.38	9.77	43	226813	2164	64269712
Multiple organ dysfunction syndrome	38.20	9.77	205	226651	101208	64170668
Myoclonic epilepsy	38.15	9.77	37	226819	1571	64270305
Therapeutic product ineffective	38.15	9.77	36	226820	1477	64270399
Myelodysplastic syndrome	38.12	9.77	25	226831	27554	64244322
Bronchopulmonary aspergillosis	38.09	9.77	10	226846	19075	64252801
Rubber sensitivity	38.08	9.77	34	226822	1298	64270578
Persecutory delusion	37.92	9.77	59	226797	4099	64267777
Discomfort	37.87	9.77	151	226705	80727	64191149
Stereotypy	37.87	9.77	28	226828	814	64271062
Acute myeloid leukaemia	37.81	9.77	25	226831	27438	64244438
Tumour lysis syndrome	37.28	9.77	11	226845	19429	64252447
Head injury	37.27	9.77	220	226636	32622	64239254
Electrocardiogram QRS complex prolonged	37.26	9.77	93	226763	9151	64262725
Shock haemorrhagic	37.14	9.77	7	226849	16784	64255092
Electrocardiogram QT prolonged	37.01	9.77	435	226421	79013	64192863
Oedema peripheral	36.91	9.77	519	226337	209798	64062078
Myoglobin urine present	36.83	9.77	24	226832	566	64271310
Plasma cell myeloma	36.79	9.77	66	226790	46009	64225867
Product substitution issue	36.64	9.77	142	226714	17719	64254157
Libido increased	36.61	9.77	38	226818	1752	64270124
Sluggishness	36.59	9.77	69	226787	5601	64266275
Hypokinesia	36.58	9.77	135	226721	16461	64255415
Toxicologic test abnormal	36.47	9.77	32	226824	1193	64270683
Nystagmus	36.31	9.77	91	226765	8977	64262899
Hypomagnesaemia	36.13	9.77	47	226809	37329	64234547
Substance use disorder	36.10	9.77	20	226836	347	64271529
Rash pruritic	36.07	9.77	94	226762	57310	64214566
Adjustment disorder with mixed anxiety and depressed mood	36.05	9.77	13	226843	74	64271802
Sleep apnoea syndrome	35.92	9.77	203	226653	29629	64242247
C-reactive protein increased	35.67	9.77	192	226664	94717	64177159
Hypothermia	35.29	9.77	151	226705	19705	64252171
Antipsychotic drug level increased	35.21	9.77	64	226792	5051	64266825
Nausea	35.21	9.77	2337	224519	783463	63488413
Neoplasm progression	35.18	9.77	56	226800	40908	64230968
Hyperammonaemia	35.15	9.77	95	226761	9809	64262067
International normalised ratio increased	35.08	9.77	151	226705	79016	64192860
Dystonic tremor	34.93	9.77	16	226840	181	64271695
Coordination abnormal	34.91	9.77	124	226732	14840	64257036
Hypokalaemia	34.88	9.77	268	226588	121635	64150241
Posture abnormal	34.86	9.77	51	226805	3355	64268521
Thrombotic microangiopathy	34.66	9.77	8	226848	16647	64255229
Cerebrovascular accident	34.60	9.77	313	226543	137270	64134606
Delirium	34.54	9.77	384	226472	68810	64203066
Disinhibition	34.46	9.77	41	226815	2202	64269674
Accidental overdose	34.43	9.77	219	226637	33338	64238538
Impaired driving ability	34.31	9.77	60	226796	4594	64267282
Coronary artery disease	34.24	9.77	104	226752	60329	64211547
Extrapyramidal disorder	34.22	9.77	148	226708	19404	64252472
Obsessive-compulsive disorder	34.08	9.77	61	226795	4757	64267119
Weight increased	34.03	9.77	987	225869	212361	64059515
Epistaxis	33.92	9.77	204	226652	97927	64173949
Vision blurred	33.82	9.77	475	226381	89841	64182035
Aspergillus infection	33.82	9.77	8	226848	16371	64255505
Torticollis	33.79	9.77	40	226816	2137	64269739
Toxic encephalopathy	33.69	9.77	93	226763	9722	64262154
Pruritus	33.61	9.77	839	226017	311561	63960315
Migraine	33.21	9.77	352	226504	62325	64209551
Device interaction	33.17	9.77	24	226832	674	64271202
Lethargy	33.16	9.77	396	226460	72198	64199678
Parosmia	33.15	9.77	59	226797	4581	64267295
Musculoskeletal pain	33.07	9.77	160	226696	81134	64190742
Cytopenia	33.07	9.77	7	226849	15464	64256412
Accidental death	32.79	9.77	52	226804	3673	64268203
Hallucination, visual	32.59	9.77	188	226668	27646	64244230
Skin ulcer	32.48	9.77	66	226790	43908	64227968
Inflammation	32.45	9.77	119	226737	65181	64206695
Areflexia	32.40	9.77	61	226795	4946	64266930
Incoherent	32.33	9.77	75	226781	7043	64264833
Panic disorder	32.24	9.77	44	226812	2713	64269163
Broncholithiasis	32.16	9.77	14	226842	139	64271737
Libido decreased	31.85	9.77	59	226797	4725	64267151
Oromandibular dystonia	31.59	9.77	26	226830	887	64270989
COVID-19	31.53	9.77	120	226736	65020	64206856
Agoraphobia	31.12	9.77	21	226835	526	64271350
Haematemesis	31.05	9.77	75	226781	46924	64224952
Withdrawal arrhythmia	30.58	9.77	10	226846	40	64271836
Parasomnia	30.57	9.77	20	226836	475	64271401
Psychogenic seizure	30.54	9.77	35	226821	1806	64270070
Pathogen resistance	30.52	9.77	4	226852	12539	64259337
Anaphylactic shock	30.50	9.77	37	226819	30291	64241585
Muscle twitching	30.38	9.77	140	226716	18858	64253018
Irritable bowel syndrome	30.31	9.77	53	226803	37316	64234560
Right ventricular failure	30.31	9.77	19	226837	21452	64250424
Freezing phenomenon	30.16	9.77	32	226824	1514	64270362
Creatinine renal clearance decreased	29.86	9.77	7	226849	14414	64257462
Rectal haemorrhage	29.84	9.77	114	226742	61703	64210173
Basal cell carcinoma	29.58	9.77	39	226817	30799	64241077
Drug level above therapeutic	29.49	9.77	71	226785	6830	64265046
Schizoaffective disorder	29.46	9.77	32	226824	1555	64270321
Stoma site hypergranulation	29.46	9.77	18	226838	378	64271498
Drug ineffective for unapproved indication	29.40	9.77	199	226657	30934	64240942
Urinary tract discomfort	29.23	9.77	17	226839	325	64271551
Encephalitis toxic	29.01	9.77	16	226840	275	64271601
Pleurothotonus	28.85	9.77	38	226818	2264	64269612
Tubulointerstitial nephritis	28.73	9.77	40	226816	30869	64241007
Stoma site pain	28.65	9.77	27	226829	1106	64270770
Tinnitus	28.63	9.77	212	226644	33921	64237955
Drug diversion	28.58	9.77	27	226829	1109	64270767
Bruxism	28.40	9.77	48	226808	3576	64268300
Weight abnormal	28.09	9.77	27	226829	1134	64270742
Vessel puncture site erythema	27.92	9.77	6	226850	0	64271876
Apathy	27.87	9.77	95	226761	11137	64260739
Affect lability	27.77	9.77	82	226774	8908	64262968
Vomiting	27.76	9.77	1621	225235	549496	63722380
Adrenal insufficiency	27.69	9.77	23	226833	22464	64249412
Poor quality sleep	27.65	9.77	136	226720	18815	64253061
Feeling guilty	27.57	9.77	23	226833	800	64271076
Hyponatraemia	27.48	9.77	362	226494	147977	64123899
Urinary bladder rupture	27.44	9.77	11	226845	87	64271789
Urinary retention	27.33	9.77	279	226577	48922	64222954
Rhinitis allergic	27.20	9.77	76	226780	8002	64263874
Cholestasis	27.04	9.77	75	226781	44797	64227079
Arthritis	27.02	9.77	178	226678	83636	64188240
Hypoventilation	26.97	9.77	63	226793	5943	64265933
Hypertonia	26.94	9.77	65	226791	6260	64265616
Jaundice cholestatic	26.70	9.77	79	226777	8591	64263285
Band neutrophil percentage increased	26.69	9.77	17	226839	385	64271491
Anorgasmia	26.68	9.77	24	226832	925	64270951
Jaundice	26.41	9.77	85	226771	48427	64223449
Coma blister	26.39	9.77	14	226842	222	64271654
Treatment noncompliance	26.31	9.77	251	226605	43231	64228645
Hypervolaemia	26.17	9.77	60	226796	38225	64233651
Dyspnoea exertional	26.15	9.77	152	226704	73578	64198298
Hypomania	26.15	9.77	60	226796	5594	64266282
Cerebellar atrophy	26.14	9.77	25	226831	1043	64270833
Fear	26.12	9.77	140	226716	20031	64251845
Alveolar osteitis	25.94	9.77	17	226839	405	64271471
Stoma site extravasation	25.92	9.77	15	226841	284	64271592
Road traffic accident	25.81	9.77	191	226665	30554	64241322
Change in seizure presentation	25.55	9.77	15	226841	292	64271584
Cough	25.51	9.77	839	226017	301309	63970567
Oedema	25.42	9.77	204	226652	91731	64180145
Hypotonia	25.38	9.77	92	226764	11120	64260756
Bone erosion	25.29	9.77	5	226851	11590	64260286
Abdominal pain	25.07	9.77	873	225983	311502	63960374
Parkinsonian gait	24.92	9.77	22	226834	827	64271049
Bacteraemia	24.84	9.77	35	226821	26876	64245000
Hereditary angioedema	24.81	9.77	47	226809	3829	64268047
Panic reaction	24.75	9.77	48	226808	3979	64267897
Aplastic anaemia	24.72	9.77	9	226847	13911	64257965
Impulsive behaviour	24.59	9.77	38	226818	2625	64269251
Logorrhoea	24.48	9.77	48	226808	4011	64267865
Diverticulitis	24.44	9.77	63	226793	38555	64233321
Cerebral infarction	24.44	9.77	69	226787	40975	64230901
Gaze palsy	24.41	9.77	37	226819	2513	64269363
Emotional distress	24.33	9.77	213	226643	35825	64236051
Somnambulism	24.27	9.77	55	226801	5086	64266790
Psychiatric symptom	24.13	9.77	62	226794	6211	64265665
Suspected suicide	23.99	9.77	76	226780	8578	64263298
Pulmonary hypertension	23.90	9.77	75	226781	43064	64228812
Therapy non-responder	23.83	9.77	135	226721	65764	64206112
Ehlers-Danlos syndrome	23.66	9.77	11	226845	129	64271747
Enthesopathy	23.63	9.77	3	226853	9635	64262241
Stupor	23.58	9.77	60	226796	5975	64265901
Tachyphrenia	23.56	9.77	31	226825	1845	64270031
Disseminated intravascular coagulation	23.51	9.77	49	226807	32299	64239577
Dysstasia	23.50	9.77	151	226705	23064	64248812
Haematotoxicity	23.48	9.77	8	226848	12888	64258988
Pulmonary arterial hypertension	23.41	9.77	33	226823	25334	64246542
Bipolar I disorder	23.39	9.77	30	226826	1741	64270135
Stress	23.32	9.77	320	226536	60214	64211662
Post-traumatic neck syndrome	23.23	9.77	31	226825	1871	64270005
Kidney transplant rejection	23.22	9.77	3	226853	9508	64262368
Knee arthroplasty	23.09	9.77	37	226819	26962	64244914
Posterior reversible encephalopathy syndrome	23.07	9.77	28	226828	22918	64248958
Blood prolactin increased	22.85	9.77	43	226813	3485	64268391
Ill-defined disorder	22.74	9.77	79	226777	43973	64227903
Nephropathy toxic	22.72	9.77	17	226839	17497	64254379
Brain scan abnormal	22.47	9.77	24	226832	1144	64270732
Lymph node calcification	22.46	9.77	14	226842	305	64271571
Muscle disorder	22.30	9.77	52	226804	4899	64266977
Self-injurious ideation	22.01	9.77	40	226816	3157	64268719
Leukopenia	21.83	9.77	239	226617	101003	64170873
Blister	21.77	9.77	181	226675	80786	64191090
Failure to suspend medication	21.74	9.77	15	226841	390	64271486
Hip arthroplasty	21.52	9.77	26	226830	21325	64250551
Diffuse large B-cell lymphoma	21.51	9.77	5	226851	10356	64261520
Postmortem blood drug level abnormal	21.50	9.77	18	226838	629	64271247
Clostridium difficile infection	21.38	9.77	61	226795	36102	64235774
Substance dependence	21.38	9.77	16	226840	474	64271402
Concussion	21.35	9.77	69	226787	7869	64264007
Coma scale abnormal	21.30	9.77	68	226788	7706	64264170
Secretion discharge	21.27	9.77	91	226765	11873	64260003
Graft versus host disease	21.25	9.77	11	226845	13802	64258074
Haematoma	21.24	9.77	87	226769	46163	64225713
Drug tolerance	21.23	9.77	58	226798	6027	64265849
Dehydration	21.22	9.77	590	226266	216173	64055703
Hyperbilirubinaemia	21.19	9.77	26	226830	21179	64250697
Haemorrhage intracranial	21.13	9.77	32	226824	23852	64248024
Post transplant lymphoproliferative disorder	21.06	9.77	4	226852	9540	64262336
Partial seizures	21.02	9.77	65	226791	7242	64264634
Hyperreflexia	20.95	9.77	64	226792	7084	64264792
Cholangitis	20.92	9.77	6	226850	10796	64261080
Hyperthermia	20.87	9.77	109	226747	15441	64256435
Attention deficit hyperactivity disorder	20.80	9.77	36	226820	2734	64269142
Seizure cluster	20.77	9.77	14	226842	350	64271526
Urinary incontinence	20.56	9.77	206	226650	35945	64235931
Squamous cell carcinoma of skin	20.55	9.77	8	226848	11868	64260008
Fluid retention	20.55	9.77	124	226732	59482	64212394
Red blood cell sedimentation rate increased	20.51	9.77	50	226806	31185	64240691
Venoocclusive liver disease	20.47	9.77	5	226851	10010	64261866
Blepharospasm	20.47	9.77	40	226816	3335	64268541
Upper respiratory tract infection	20.35	9.77	161	226695	72624	64199252
Hyperkinesia	20.32	9.77	34	226822	2512	64269364
Metastases to liver	20.30	9.77	33	226823	23908	64247968
Rheumatic fever	20.29	9.77	4	226852	9290	64262586
Lymphopenia	20.26	9.77	37	226819	25620	64246256
Euphoric mood	20.24	9.77	60	226796	6531	64265345
Nephrectomy	20.23	9.77	25	226831	1397	64270479
Food craving	20.20	9.77	25	226831	1399	64270477
Dysphemia	20.18	9.77	38	226818	3081	64268795
Sensory loss	20.17	9.77	80	226776	10089	64261787
Mutism	20.16	9.77	30	226826	2004	64269872
Physical assault	20.12	9.77	26	226830	1520	64270356
Oropharyngeal oedema	20.02	9.77	12	226844	243	64271633
Liver function test increased	20.00	9.77	50	226806	30920	64240956
Liver disorder	20.00	9.77	108	226748	53243	64218633
Mobility decreased	19.99	9.77	199	226657	85641	64186235
Pseudomonas infection	19.99	9.77	20	226836	17863	64254013
Pneumonitis	19.98	9.77	100	226756	50265	64221611
Chronic kidney disease	19.70	9.77	121	226735	57798	64214078
Soft tissue injury	19.69	9.77	26	226830	1553	64270323
Stoma site infection	19.68	9.77	23	226833	1212	64270664
Blood creatine phosphokinase	19.63	9.77	9	226847	102	64271774
Impulse-control disorder	19.57	9.77	26	226830	1562	64270314
Hyperphagia	19.44	9.77	31	226825	2200	64269676
Staphylococcal infection	19.32	9.77	102	226754	50576	64221300
Liver function test abnormal	19.22	9.77	126	226730	59275	64212601
Postoperative respiratory failure	19.22	9.77	10	226846	152	64271724
Head titubation	19.22	9.77	19	226837	826	64271050
Sleep disorder	19.22	9.77	306	226550	59403	64212473
Physical abuse	19.19	9.77	6	226850	20	64271856
Medication error	19.19	9.77	264	226592	49702	64222174
White blood cell count decreased	19.15	9.77	416	226440	157421	64114455
Encephalopathy	19.14	9.77	302	226554	58517	64213359
Stoma site inflammation	19.14	9.77	16	226840	558	64271318
Atrial flutter	19.12	9.77	24	226832	19356	64252520
Sinusitis	19.07	9.77	380	226476	145548	64126328
Phaeochromocytoma malignant	19.06	9.77	8	226848	72	64271804
Aphasia	19.05	9.77	224	226632	40682	64231194
Prostate cancer	19.02	9.77	25	226831	19770	64252106
Allodynia	18.97	9.77	23	226833	1260	64270616
Acute coronary syndrome	18.96	9.77	24	226832	19286	64252590
Psychotic disorder due to a general medical condition	18.95	9.77	12	226844	269	64271607
Dependence	18.85	9.77	30	226826	2125	64269751
Staphylococcal sepsis	18.79	9.77	11	226845	12888	64258988
Post-traumatic stress disorder	18.76	9.77	44	226812	4161	64267715
Blood sodium decreased	18.75	9.77	172	226684	29310	64242566
Bladder pain	18.71	9.77	27	226829	1754	64270122
Muscle spasms	18.67	9.77	638	226218	140385	64131491
Compulsive shopping	18.66	9.77	18	226838	759	64271117
Hyperchloraemia	18.63	9.77	20	226836	959	64270917
Purpura fulminans	18.55	9.77	10	226846	164	64271712
Choreoathetosis	18.31	9.77	24	226832	1423	64270453
Spasmodic dysphonia	18.28	9.77	10	226846	169	64271707
Obsessive-compulsive personality disorder	18.28	9.77	9	226847	121	64271755
Tongue discolouration	18.14	9.77	38	226818	3330	64268546
Social anxiety disorder	18.10	9.77	14	226842	436	64271440
Onychophagia	17.99	9.77	8	226848	84	64271792
Carpal tunnel syndrome	17.94	9.77	106	226750	15722	64256154
Respiratory rate decreased	17.91	9.77	45	226811	4446	64267430
Drug eruption	17.86	9.77	66	226790	36070	64235806
Flat affect	17.85	9.77	27	226829	1830	64270046
Homicidal ideation	17.84	9.77	37	226819	3220	64268656
Brain malformation	17.84	9.77	7	226849	52	64271824
Heart rate increased	17.83	9.77	464	226392	98211	64173665
Congenital inguinal hernia	17.81	9.77	5	226851	10	64271866
Acute generalised exanthematous pustulosis	17.78	9.77	14	226842	14044	64257832
Rash maculo-papular	17.74	9.77	95	226761	46931	64224945
Epstein-Barr virus infection	17.70	9.77	11	226845	12477	64259399
Thrombosis	17.62	9.77	161	226695	70481	64201395
Hyperammonaemic encephalopathy	17.61	9.77	42	226814	4016	64267860
Angina pectoris	17.60	9.77	90	226766	44991	64226885
Osteoporosis	17.59	9.77	82	226774	41998	64229878
Prescribed underdose	17.52	9.77	116	226740	17899	64253977
Therapeutic response unexpected	17.47	9.77	111	226745	16890	64254986
Gambling disorder	17.45	9.77	27	226829	1867	64270009
Blood loss anaemia	17.37	9.77	14	226842	13878	64257998
Cerebral artery thrombosis	17.34	9.77	20	226836	1039	64270837
Influenza like illness	17.23	9.77	309	226547	61393	64210483
Tic	17.06	9.77	32	226824	2587	64269289
Neglect of personal appearance	17.00	9.77	9	226847	142	64271734
Injection site erythema	16.96	9.77	163	226693	70637	64201239
Haemoptysis	16.92	9.77	102	226754	48946	64222930
Uveitis	16.92	9.77	12	226844	12696	64259180
Rash erythematous	16.85	9.77	101	226755	48532	64223344
Injection site pruritus	16.84	9.77	72	226784	37754	64234122
Rapid eye movement sleep behaviour disorder	16.84	9.77	12	226844	329	64271547
Enuresis	16.84	9.77	33	226823	2757	64269119
Lymphadenopathy	16.69	9.77	96	226760	46590	64225286
Animal scratch	16.68	9.77	19	226837	974	64270902
End stage renal disease	16.63	9.77	8	226848	10467	64261409
Aspiration	16.58	9.77	109	226747	16776	64255100
BK virus infection	16.58	9.77	3	226853	7409	64264467
Reduced facial expression	16.57	9.77	28	226828	2085	64269791
Clonus	16.56	9.77	53	226803	6014	64265862
Hyperglycaemia	16.52	9.77	136	226720	60832	64211044
Oculogyric crisis	16.52	9.77	31	226825	2507	64269369
Cellulitis	16.45	9.77	231	226625	93426	64178450
Infantile spasms	16.42	9.77	11	226845	272	64271604
Intellectual disability	16.41	9.77	19	226837	991	64270885
Osteonecrosis	16.41	9.77	48	226808	28181	64243695
HIV peripheral neuropathy	16.37	9.77	6	226850	36	64271840
Obsessive thoughts	16.31	9.77	19	226837	998	64270878
Muscle contracture	16.26	9.77	28	226828	2117	64269759
Burning sensation	16.16	9.77	255	226601	49409	64222467
Dysphagia	16.15	9.77	491	226365	106321	64165555
Pericardial effusion	16.11	9.77	77	226779	39177	64232699
Niemann-Pick disease	16.10	9.77	6	226850	38	64271838
Transfusion	16.02	9.77	24	226832	17970	64253906
Learning disorder	15.73	9.77	14	226842	532	64271344
Electrocardiogram QRS complex shortened	15.68	9.77	15	226841	626	64271250
Antidepressant drug level above therapeutic	15.60	9.77	14	226842	538	64271338
Tunnel vision	15.60	9.77	19	226837	1046	64270830
Distractibility	15.58	9.77	15	226841	631	64271245
Labelled drug-drug interaction medication error	15.55	9.77	34	226822	22028	64249848
Myelocyte count increased	15.44	9.77	16	226840	736	64271140
Band neutrophil count increased	15.41	9.77	15	226841	640	64271236
Patient uncooperative	15.28	9.77	14	226842	553	64271323
Illness anxiety disorder	15.27	9.77	10	226846	238	64271638
Heat stroke	15.20	9.77	22	226834	1433	64270443
Haemophagocytic lymphohistiocytosis	15.19	9.77	24	226832	17585	64254291
Myelocyte percentage increased	15.16	9.77	10	226846	241	64271635
Cushingoid	15.14	9.77	4	226852	7599	64264277
Conversion disorder	15.13	9.77	24	226832	1695	64270181
Gastrointestinal hypomotility	14.99	9.77	24	226832	1709	64270167
Increased appetite	14.94	9.77	73	226783	10073	64261803
Decreased appetite	14.90	9.77	823	226033	280466	63991410
Periorbital swelling	14.90	9.77	25	226831	1851	64270025
Abulia	14.88	9.77	17	226839	874	64271002
Limb injury	14.88	9.77	137	226719	23368	64248508
Blood pressure fluctuation	14.85	9.77	114	226742	51757	64220119
Dysmetria	14.80	9.77	17	226839	879	64270997
Sensorimotor disorder	14.74	9.77	16	226840	777	64271099
Second primary malignancy	14.73	9.77	13	226843	12324	64259552
Respiratory dyskinesia	14.70	9.77	6	226850	50	64271826
Petit mal epilepsy	14.69	9.77	45	226811	4987	64266889
Drop attacks	14.69	9.77	18	226838	997	64270879
Sleep talking	14.69	9.77	18	226838	997	64270879
Paralysis	14.69	9.77	80	226776	11515	64260361
Formication	14.68	9.77	41	226815	4316	64267560
Renal hypertension	14.65	9.77	9	226847	191	64271685
Communication disorder	14.64	9.77	37	226819	3669	64268207
Blood urea increased	14.62	9.77	93	226763	44060	64227816
Oral candidiasis	14.59	9.77	38	226818	23174	64248702
Anticonvulsant drug level below therapeutic	14.56	9.77	18	226838	1006	64270870
Poisoning deliberate	14.53	9.77	89	226767	13369	64258507
Generalised anxiety disorder	14.52	9.77	25	226831	1890	64269986
Pain	14.50	9.77	1715	225141	551796	63720080
Psychotic behaviour	14.49	9.77	18	226838	1011	64270865
Mental disability	14.49	9.77	6	226850	52	64271824
Social avoidant behaviour	14.49	9.77	42	226814	4515	64267361
Pneumonia bacterial	14.44	9.77	19	226837	15016	64256860
Retinal detachment	14.43	9.77	5	226851	7971	64263905
Postictal paralysis	14.41	9.77	11	226845	336	64271540
Hypoalbuminaemia	14.39	9.77	25	226831	17649	64254227
Metabolic acidosis	14.32	9.77	170	226686	70788	64201088
Blood test abnormal	14.23	9.77	86	226770	12857	64259019
Cardiac failure chronic	14.21	9.77	7	226849	9034	64262842
Device dislocation	14.20	9.77	125	226731	21053	64250823
Nephrotic syndrome	14.16	9.77	8	226848	9559	64262317
Dermatitis acneiform	14.10	9.77	6	226850	8437	64263439
Peroneal nerve palsy	14.09	9.77	46	226810	5275	64266601
Affective disorder	14.06	9.77	53	226803	6527	64265349
Abdominal pain upper	14.05	9.77	489	226367	174541	64097335
Sexual abuse	14.03	9.77	8	226848	147	64271729
Priapism	14.01	9.77	38	226818	3932	64267944
Stoma site irritation	13.97	9.77	9	226847	208	64271668
Adverse drug reaction	13.93	9.77	98	226758	45366	64226510
Erythema multiforme	13.92	9.77	21	226835	15680	64256196
Dysmorphism	13.91	9.77	13	226843	527	64271349
Candida infection	13.87	9.77	60	226796	31359	64240517
Escherichia sepsis	13.84	9.77	4	226852	7161	64264715
Pancreatitis acute	13.82	9.77	91	226765	42764	64229112
Terminal insomnia	13.80	9.77	17	226839	947	64270929
Accidental poisoning	13.79	9.77	21	226835	1432	64270444
Antidepressant drug level increased	13.78	9.77	11	226845	359	64271517
Suicidal behaviour	13.75	9.77	31	226825	2856	64269020
Hepatic cirrhosis	13.68	9.77	47	226809	26251	64245625
Product use in unapproved indication	13.60	9.77	496	226360	176122	64095754
Postmortem blood drug level increased	13.53	9.77	15	226841	746	64271130
Hypersexuality	13.51	9.77	21	226835	1458	64270418
Staphylococcal bacteraemia	13.50	9.77	10	226846	10345	64261531
Gout	13.50	9.77	35	226821	21378	64250498
Hypnopompic hallucination	13.49	9.77	6	226850	63	64271813
Brain injury	13.47	9.77	70	226786	9895	64261981
Motor dysfunction	13.43	9.77	77	226779	11296	64260580
Sleep disorder due to a general medical condition	13.40	9.77	61	226795	8173	64263703
Abscess	13.40	9.77	30	226826	19274	64252602
Incorrect route of product administration	13.36	9.77	133	226723	23165	64248711
Oropharyngeal pain	13.30	9.77	226	226630	88641	64183235
Wrong patient received product	13.27	9.77	36	226820	3726	64268150
Urosepsis	13.26	9.77	37	226819	22057	64249819
Polyarthritis	13.16	9.77	9	226847	9706	64262170
Poverty of speech	13.14	9.77	13	226843	566	64271310
Disorganised speech	13.12	9.77	22	226834	1628	64270248
Ketosis-prone diabetes mellitus	13.11	9.77	4	226852	12	64271864
Locomotive syndrome	13.11	9.77	4	226852	12	64271864
Laryngomalacia	13.11	9.77	4	226852	12	64271864
Blood bicarbonate decreased	13.01	9.77	42	226814	4787	64267089
Cyanosis	12.96	9.77	127	226729	22028	64249848
Metastases to central nervous system	12.93	9.77	18	226838	13894	64257982
Pneumothorax	12.93	9.77	43	226813	24255	64247621
Psoriatic arthropathy	12.92	9.77	94	226762	43187	64228689
Forced expiratory volume decreased	12.81	9.77	53	226803	6814	64265062
Helplessness	12.81	9.77	10	226846	316	64271560
Cystitis haemorrhagic	12.75	9.77	6	226850	7950	64263926
Ulcer	12.71	9.77	40	226816	22950	64248926
Eye movement disorder	12.71	9.77	54	226802	7025	64264851
Bacterial infection	12.70	9.77	45	226811	24905	64246971
Acute hepatic failure	12.70	9.77	48	226808	26064	64245812
Heparin-induced thrombocytopenia	12.68	9.77	7	226849	8472	64263404
Peripheral pulse decreased	12.64	9.77	5	226851	38	64271838
Glossopharyngeal nerve disorder	12.64	9.77	5	226851	38	64271838
Gastric ulcer	12.59	9.77	59	226797	30175	64241701
Haematuria traumatic	12.53	9.77	8	226848	182	64271694
Death	12.49	9.77	1907	224949	480798	63791078
Pupillary reflex impaired	12.47	9.77	31	226825	3042	64268834
Oral pain	12.45	9.77	52	226804	27441	64244435
Akinesia	12.43	9.77	31	226825	3048	64268828
Bulbar palsy	12.43	9.77	9	226847	253	64271623
Haemoglobin urine	12.41	9.77	7	226849	126	64271750
Intensive care unit acquired weakness	12.39	9.77	22	226834	1705	64270171
Somatic symptom disorder	12.39	9.77	23	226833	1845	64270031
Tenderness	12.39	9.77	32	226824	19570	64252306
Pulmonary tuberculosis	12.34	9.77	5	226851	7239	64264637
Bradycardia	12.33	9.77	521	226335	117698	64154178
Pneumonia fungal	12.33	9.77	8	226848	8869	64263007
Postmortem blood drug level	12.31	9.77	9	226847	257	64271619
Sudden unexplained death in epilepsy	12.30	9.77	13	226843	612	64271264
Barotrauma	12.23	9.77	8	226848	190	64271686
Skin toxicity	12.19	9.77	4	226852	6598	64265278
Polyneuropathy	12.17	9.77	33	226823	19861	64252015
Peritonitis	12.17	9.77	46	226810	24977	64246899
Duodenal ulcer	12.14	9.77	20	226836	14415	64257461
Cluster headache	12.14	9.77	15	226841	838	64271038
Lupus-like syndrome	12.11	9.77	8	226848	8783	64263093
Petechiae	12.08	9.77	30	226826	18596	64253280
Lower gastrointestinal haemorrhage	12.02	9.77	19	226837	13920	64257956
Alcohol abuse	12.00	9.77	41	226815	4811	64267065
Asterixis	11.97	9.77	26	226830	2337	64269539
Poor feeding infant	11.94	9.77	7	226849	136	64271740
Feeling drunk	11.92	9.77	37	226819	4130	64267746
Localised infection	11.90	9.77	60	226796	30101	64241775
Anal spasm	11.89	9.77	3	226853	3	64271873
Chemical burn of gastrointestinal tract	11.89	9.77	3	226853	3	64271873
Cerebral atrophy	11.88	9.77	54	226802	7231	64264645
Escherichia infection	11.86	9.77	22	226834	15146	64256730
Diabetes mellitus inadequate control	11.86	9.77	37	226819	21284	64250592
Hyperuricaemia	11.85	9.77	11	226845	10180	64261696
Circulatory collapse	11.71	9.77	70	226786	33662	64238214
Cardiac infection	11.70	9.77	9	226847	278	64271598
Drug level increased	11.67	9.77	177	226679	34019	64237857
Excessive eye blinking	11.66	9.77	18	226838	1242	64270634
Product complaint	11.64	9.77	77	226779	11877	64259999
Autoimmune hepatitis	11.59	9.77	11	226845	10073	64261803
Choking	11.58	9.77	70	226786	10468	64261408
Parotid gland enlargement	11.55	9.77	14	226842	767	64271109
Device expulsion	11.53	9.77	37	226819	21099	64250777
Deafness neurosensory	11.53	9.77	4	226852	6370	64265506
Haemorrhage	11.48	9.77	203	226653	79148	64192728
Organising pneumonia	11.48	9.77	9	226847	9046	64262830
Mouth ulceration	11.44	9.77	67	226789	32377	64239499
Asthma	11.41	9.77	426	226430	94799	64177077
Medical device site erosion	11.37	9.77	5	226851	51	64271825
Inappropriate affect	11.36	9.77	18	226838	1270	64270606
Congenital knee deformity	11.36	9.77	4	226852	21	64271855
Chest discomfort	11.36	9.77	316	226540	115790	64156086
Developmental delay	11.31	9.77	16	226840	1021	64270855
Anhidrosis	11.27	9.77	8	226848	218	64271658
Left ventricular dysfunction	11.24	9.77	27	226829	16927	64254949
Brain oedema	11.24	9.77	123	226733	21952	64249924
Embolism	11.21	9.77	16	226840	12219	64259657
Impaired self-care	11.20	9.77	25	226831	2288	64269588
Metastases to lung	11.19	9.77	23	226833	15241	64256635
COVID-19 pneumonia	11.17	9.77	26	226830	16478	64255398
Urine oxalate increased	11.14	9.77	8	226848	222	64271654
Abnormal sleep-related event	11.10	9.77	14	226842	799	64271077
Body height increased	11.10	9.77	6	226850	99	64271777
Snoring	11.09	9.77	39	226817	4643	64267233
Fibromyalgia	11.08	9.77	182	226674	35549	64236327
Dysgraphia	11.05	9.77	32	226824	3439	64268437
Febrile bone marrow aplasia	11.04	9.77	14	226842	11241	64260635
Oesophagitis	11.02	9.77	39	226817	21591	64250285
Ammonia abnormal	11.01	9.77	7	226849	158	64271718
Dairy intolerance	10.96	9.77	5	226851	56	64271820
Dizziness	10.95	9.77	1698	225158	428465	63843411
Flight of ideas	10.93	9.77	13	226843	698	64271178
Hypoxic-ischaemic encephalopathy	10.92	9.77	52	226804	7100	64264776
Chronic spontaneous urticaria	10.87	9.77	11	226845	492	64271384
Enteritis	10.86	9.77	16	226840	12061	64259815
Cataplexy	10.85	9.77	14	226842	817	64271059
Decreased activity	10.81	9.77	52	226804	7128	64264748
Iron deficiency anaemia	10.80	9.77	40	226816	21849	64250027
Anticonvulsant drug level increased	10.75	9.77	25	226831	2352	64269524
Dissociative identity disorder	10.73	9.77	5	226851	59	64271817
Large intestine operation	10.69	9.77	3	226853	6	64271870
CYP2D6 polymorphism	10.69	9.77	3	226853	6	64271870
Neuropsychiatric symptoms	10.67	9.77	15	226841	951	64270925
Full blood count decreased	10.67	9.77	42	226814	22540	64249336
Nodal rhythm	10.64	9.77	28	226828	2846	64269030
Blood growth hormone increased	10.61	9.77	12	226844	610	64271266
Drug resistance	10.59	9.77	76	226780	35026	64236850
Sexual dysfunction	10.58	9.77	48	226808	6423	64265453
Thrombocytosis	10.57	9.77	6	226850	7150	64264726
Sternal fracture	10.56	9.77	24	226832	2223	64269653
Sebaceous gland infection	10.54	9.77	6	226850	110	64271766
Blood uric acid increased	10.49	9.77	8	226848	8155	64263721
Intestinal perforation	10.46	9.77	24	226832	15289	64256587
Orthopnoea	10.46	9.77	10	226846	9124	64262752
Drug detoxification	10.43	9.77	8	226848	246	64271630
Narcotic bowel syndrome	10.43	9.77	8	226848	246	64271630
Device related infection	10.40	9.77	64	226792	30562	64241314
Nail disorder	10.40	9.77	9	226847	8615	64263261
Alcoholism	10.39	9.77	31	226825	3386	64268490
Colon cancer	10.39	9.77	18	226838	12721	64259155
Sensitivity to weather change	10.38	9.77	49	226807	6665	64265211
Stoma site pruritus	10.37	9.77	3	226853	7	64271869
Homeless	10.35	9.77	6	226850	114	64271762
Acute respiratory failure	10.32	9.77	119	226737	49815	64222061
Pyelonephritis	10.30	9.77	29	226827	17237	64254639
Therapy interrupted	10.29	9.77	36	226820	20000	64251876
Chest pain	10.29	9.77	703	226153	235277	64036599
Facial bones fracture	10.29	9.77	36	226820	4276	64267600
Anticonvulsant drug level decreased	10.27	9.77	21	226835	1809	64270067
Cataract	10.27	9.77	123	226733	51139	64220737
Systemic candida	10.25	9.77	3	226853	5326	64266550
Infective pulmonary exacerbation of cystic fibrosis	10.25	9.77	16	226840	11780	64260096
Gastrointestinal toxicity	10.23	9.77	3	226853	5319	64266557
Initial insomnia	10.21	9.77	44	226812	5760	64266116
Tonic clonic movements	10.20	9.77	22	226834	1967	64269909
Fear of injection	10.20	9.77	4	226852	5908	64265968
Device use error	10.18	9.77	5	226851	6466	64265410
Osteoarthritis	10.16	9.77	159	226697	63177	64208699
Gastric haemorrhage	10.15	9.77	20	226836	13461	64258415
Drug tolerance decreased	10.15	9.77	6	226850	6992	64264884
Monocyte percentage increased	10.12	9.77	22	226834	1978	64269898
Transcription medication error	10.11	9.77	9	226847	342	64271534
Trismus	10.08	9.77	39	226817	4862	64267014
Product quality issue	10.08	9.77	154	226702	29645	64242231
Accidental exposure to product by child	10.01	9.77	25	226831	2460	64269416
Illusion	10.00	9.77	19	226837	1551	64270325
Metabolic surgery	9.99	9.77	14	226842	885	64270991
Injection site swelling	9.99	9.77	95	226761	41258	64230618
Pneumatosis intestinalis	9.95	9.77	3	226853	5226	64266650
Colitis microscopic	9.92	9.77	7	226849	7425	64264451
Confabulation	9.85	9.77	10	226846	449	64271427
Irregular sleep phase	9.85	9.77	5	226851	72	64271804
Creatine urine increased	9.83	9.77	3	226853	9	64271867
Toxic leukoencephalopathy	9.80	9.77	14	226842	901	64270975
Flank pain	9.80	9.77	27	226829	16162	64255714
Enterocolitis	9.79	9.77	17	226839	12001	64259875

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Tricuspid valve incompetence	33.40	27.86	12	318	61	84287

Pharmacologic Action:

Source	Code	Description
ATC	N03AE01	NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Benzodiazepine derivatives
FDA CS	M0002356	Benzodiazepines
CHEBI has role	CHEBI:35474	anti-anxiety agents
CHEBI has role	CHEBI:35623	anticonvulsants
CHEBI has role	CHEBI:50268	GABA modulators
MeSH PA	D000927	Anticonvulsants
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D018682	GABA Agents
MeSH PA	D018757	GABA Modulators
MeSH PA	D018377	Neurotransmitter Agents
FDA EPC	N0000175694	Benzodiazepine

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Myoclonic seizure	indication	37356005
Atonic seizure	indication	42365007
Absence seizure	indication	79631006
Lennox-Gastaut syndrome	indication	230418006
Panic disorder	indication	371631005	DOID:594
Akathisia	off-label use	285145004
Manic Bipolar Disorder Adjunct Treatment	off-label use
Suicidal thoughts	contraindication	6471006
Alcohol intoxication	contraindication	25702006
Depressive disorder	contraindication	35489007
Hepatic failure	contraindication	59927004
Substance abuse	contraindication	66214007
Sleep apnea	contraindication	73430006	DOID:0050847
Decreased respiratory function	contraindication	80954004
Open-angle glaucoma	contraindication	84494001	DOID:1067
Kidney disease	contraindication	90708001	DOID:557
Liver function tests abnormal	contraindication	166603001
Disease of liver	contraindication	235856003	DOID:409
Syncope	contraindication	271594007
Pregnancy, function	contraindication	289908002
At risk for aspiration	contraindication	371736008
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Breastfeeding (mother)	contraindication	413712001
Chronic lung disease	contraindication	413839001
Central nervous system depression	contraindication	418072004
Porphyria	contraindication	418470004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.65	acidic
pKa2	1.65	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
GABA-A receptor alpha-1/beta-2/gamma-2	Ion channel	P14867 P18507 P47870	GBRA1_HUMAN GBRG2_HUMAN GBRB2_HUMAN	POSITIVE ALLOSTERIC MODULATOR	Ki	8.07	WOMBAT-PK	CHEMBL
GABA-A receptor; anion channel	Ion channel	O00591 O14764 P14867 P18505 P18507 P28472 P31644 P34903 P47869 P47870 P48169 P78334 Q16445 Q8N1C3 Q99928 Q9UN88	GBRP_HUMAN GBRD_HUMAN GBRA1_HUMAN GBRB1_HUMAN GBRG2_HUMAN GBRB3_HUMAN GBRA5_HUMAN GBRA3_HUMAN GBRA2_HUMAN GBRB2_HUMAN GBRA4_HUMAN GBRE_HUMAN GBRA6_HUMAN GBRG1_HUMAN GBRG3_HUMAN GBRT_HUMAN		Ki	9.07	CHEMBL
GABA-A receptor; anion channel	Ion channel		GBRP_RAT GBRB1_RAT GBRD_RAT GBRG2_RAT GBRA5_RAT GBRA3_RAT GBRG1_RAT GBRA2_RAT GBRA4_RAT GBRG3_RAT GBRA6_RAT GBRA1_RAT GBRB3_RAT GBRB2_RAT Q91ZM7_RAT GBRE_RAT		IC50	8.77	CHEMBL
GABA-A receptor; anion channel	Ion channel		GBRA1_BOVIN GBRB1_BOVIN GBRA2_BOVIN GBRA3_BOVIN GBRA4_BOVIN GBRG2_BOVIN		Ki	9.07	CHEMBL

External reference:

ID	Source
4017791	VUID
N0000146152	NUI
D00280	KEGG_DRUG
202585	RXNORM
4017791	VANDF
C0009011	UMLSCUI
CHEBI:3756	CHEBI
CHEMBL452	ChEMBL_ID
DB01068	DRUGBANK_ID
D002998	MESH_DESCRIPTOR_UI
2802	PUBCHEM_CID
6963	IUPHAR_LIGAND_ID
2765	INN_ID
5PE9FDE8GB	UNII
1345	MMSL
377	MMSL
4477	MMSL
d00197	MMSL
001635	NDDF
387383007	SNOMEDCT_US
69708003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Klonopin	HUMAN PRESCRIPTION DRUG LABEL	1	0004-0058	TABLET	1 mg	ORAL	NDA	30 sections
Klonopin	HUMAN PRESCRIPTION DRUG LABEL	1	0004-0068	TABLET	0.50 mg	ORAL	NDA	30 sections
Klonopin	HUMAN PRESCRIPTION DRUG LABEL	1	0004-0098	TABLET	2 mg	ORAL	NDA	30 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0832	TABLET	0.50 mg	ORAL	ANDA	20 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3212	TABLET	1 mg	ORAL	ANDA	20 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3213	TABLET	2 mg	ORAL	ANDA	20 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0093-9290	TABLET, ORALLY DISINTEGRATING	0.13 mg	ORAL	ANDA	27 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0093-9291	TABLET, ORALLY DISINTEGRATING	0.25 mg	ORAL	ANDA	27 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0093-9292	TABLET, ORALLY DISINTEGRATING	0.50 mg	ORAL	ANDA	27 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0093-9293	TABLET, ORALLY DISINTEGRATING	1 mg	ORAL	ANDA	27 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0093-9293	TABLET, ORALLY DISINTEGRATING	1 mg	ORAL	ANDA	27 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0093-9294	TABLET, ORALLY DISINTEGRATING	2 mg	ORAL	ANDA	27 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-3003	TABLET	0.50 mg	ORAL	ANDA	24 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-3004	TABLET	1 mg	ORAL	ANDA	24 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-3005	TABLET	2 mg	ORAL	ANDA	24 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0555-0094	TABLET, ORALLY DISINTEGRATING	0.13 mg	ORAL	ANDA	27 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0555-0095	TABLET, ORALLY DISINTEGRATING	0.25 mg	ORAL	ANDA	27 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0555-0096	TABLET, ORALLY DISINTEGRATING	0.50 mg	ORAL	ANDA	27 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0555-0097	TABLET, ORALLY DISINTEGRATING	1 mg	ORAL	ANDA	27 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0555-0098	TABLET, ORALLY DISINTEGRATING	2 mg	ORAL	ANDA	27 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8234	TABLET	0.50 mg	ORAL	ANDA	26 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8235	TABLET	1 mg	ORAL	ANDA	26 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8236	TABLET	2 mg	ORAL	ANDA	26 sections
CLONAZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	16590-058	TABLET	0.50 mg	ORAL	ANDA	23 sections
CLONAZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	16590-059	TABLET	1 mg	ORAL	ANDA	23 sections
CLONAZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	16590-481	TABLET	2 mg	ORAL	ANDA	23 sections
KLONOPIN	HUMAN PRESCRIPTION DRUG LABEL	1	16590-693	TABLET	0.50 mg	ORAL	NDA	25 sections
KLONOPIN	HUMAN PRESCRIPTION DRUG LABEL	1	16590-935	TABLET	1 mg	ORAL	NDA	26 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	16729-136	TABLET	0.50 mg	ORAL	ANDA	27 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	16729-137	TABLET	1 mg	ORAL	ANDA	27 sections