clonazepam Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diazepam derivatives	703	1622-61-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: clonazepam lonazep klonopin	An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses. Molecular weight: 315.71 Formula: C15H10ClN3O3 CLOGP: 2.38 LIPINSKI: 0 HAC: 6 HDO: 1 TPSA: 87.28 ALOGS: -4.47 ROTB: 2 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

clonazepam
lonazep
klonopin

An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.

Molecular weight: 315.71
Formula: C15H10ClN3O3
CLOGP: 2.38
LIPINSKI: 0
HAC: 6
HDO: 1
TPSA: 87.28
ALOGS: -4.47
ROTB: 2

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
8	mg	O
8	mg	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.10 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.42 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	98 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	2.90 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	0.88 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.15 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	38 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
June 4, 1975	FDA	ROCHE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	1871.71	9.73	2446	163998	143474	46376144
Toxicity to various agents	702.21	9.73	1994	164450	209772	46309846
Suicide attempt	475.83	9.73	767	165677	54269	46465349
Drug abuse	448.28	9.73	808	165636	62600	46457018
Anxiety	389.03	9.73	1477	164967	180480	46339138
Respiratory arrest	372.89	9.73	528	165916	33288	46486330
Suicidal ideation	363.97	9.73	691	165753	55691	46463927
Intentional overdose	352.13	9.73	740	165704	64204	46455414
Rheumatoid arthritis	351.08	9.73	211	166233	240004	46279614
Depression	318.56	9.73	1325	165119	168779	46350839
Seizure	303.56	9.73	1047	165397	122007	46397611
Cardio-respiratory arrest	301.36	9.73	662	165782	59207	46460411
Sopor	279.19	9.73	349	166095	19479	46500139
Overdose	272.97	9.73	892	165552	101087	46418531
Somnolence	236.32	9.73	1144	165300	155377	46364241
Drug withdrawal syndrome	231.57	9.73	378	166066	27006	46492612
Cardiac arrest	201.25	9.73	744	165700	89655	46429963
Irritability	195.71	9.73	362	166082	28584	46491034
Contraindicated product administered	194.59	9.73	27	166417	79920	46439698
Psychotic disorder	192.27	9.73	313	166131	22308	46497310
Acute kidney injury	187.47	9.73	347	166097	235508	46284110
Insomnia	185.40	9.73	1112	165332	163812	46355806
Intentional self-injury	175.80	9.73	312	166132	23854	46495764
Synovitis	168.23	9.73	13	166431	61062	46458556
Tremor	167.11	9.73	835	165609	114804	46404814
Drug dependence	153.95	9.73	264	166180	19637	46499981
Drug hypersensitivity	149.55	9.73	413	166031	243412	46276206
Panic attack	149.38	9.73	263	166181	19979	46499639
Febrile neutropenia	139.57	9.73	82	166362	94545	46425073
Poisoning	138.93	9.73	208	166236	13786	46505832
Anaemia	135.68	9.73	463	165981	255316	46264302
Schizophrenia	130.60	9.73	157	166287	8411	46511207
Agitation	129.95	9.73	464	165980	54951	46464667
Stubbornness	127.54	9.73	43	166401	190	46519428
Hypomania	126.11	9.73	113	166331	4275	46515343
Withdrawal syndrome	124.09	9.73	228	166216	17906	46501712
Treatment failure	120.73	9.73	93	166351	92994	46426624
Drug intolerance	117.01	9.73	216	166228	146833	46372785
Anger	114.58	9.73	174	166270	11678	46507940
Intentional product misuse	111.68	9.73	396	166048	46732	46472886
Sedation	110.31	9.73	249	166195	22661	46496957
Abnormal behaviour	107.17	9.73	234	166210	20824	46498794
Neutropenia	105.59	9.73	220	166224	142984	46376634
Diarrhoea	104.97	9.73	1387	165057	558215	45961403
Mental disorder	101.65	9.73	238	166206	22187	46497431
Unresponsive to stimuli	101.31	9.73	298	166146	31876	46487742
Aggression	99.43	9.73	238	166206	22506	46497112
Thrombocytopenia	98.00	9.73	189	166255	126392	46393226
Mania	97.53	9.73	154	166290	10692	46508926
Neuroleptic malignant syndrome	97.37	9.73	156	166288	10966	46508652
Crying	96.52	9.73	225	166219	20916	46498702
Systemic lupus erythematosus	93.97	9.73	58	166386	65122	46454496
Sepsis	92.84	9.73	218	166226	135796	46383822
Atrial fibrillation	92.71	9.73	141	166303	103449	46416169
Rash	92.70	9.73	819	165625	355693	46163925
Disturbance in attention	92.48	9.73	285	166159	31275	46488343
Restless legs syndrome	91.02	9.73	185	166259	15658	46503960
Thinking abnormal	90.54	9.73	141	166303	9673	46509945
Paranoia	89.18	9.73	146	166298	10451	46509167
Amnesia	87.88	9.73	337	166107	41294	46478324
Memory impairment	87.09	9.73	522	165922	76815	46442803
Depressed level of consciousness	86.80	9.73	368	166076	47201	46472417
Infusion related reaction	85.61	9.73	143	166301	101065	46418553
Joint swelling	85.01	9.73	305	166139	165768	46353850
Feeling abnormal	84.63	9.73	747	165697	124313	46395305
Ataxia	84.02	9.73	166	166278	13764	46505854
Weight increased	83.83	9.73	926	165518	163547	46356071
Cardiac failure	83.58	9.73	97	166347	79851	46439767
Mood altered	82.10	9.73	158	166286	12849	46506769
Speech disorder	81.51	9.73	299	166145	35868	46483750
Dyspnoea	79.85	9.73	1326	165118	514222	46005396
Drug withdrawal convulsions	79.29	9.73	53	166391	1288	46518330
Dyskinesia	79.06	9.73	255	166189	28670	46490948
Tardive dyskinesia	79.02	9.73	115	166329	7428	46512190
Dystonia	78.87	9.73	143	166301	11114	46508504
Nervousness	75.99	9.73	249	166195	28226	46491392
Interstitial lung disease	72.38	9.73	52	166392	53897	46465721
Hallucination	72.28	9.73	361	166083	49590	46470028
Hyperhidrosis	71.40	9.73	554	165890	88754	46430864
Pancytopenia	71.18	9.73	121	166323	84937	46434681
Infection	69.25	9.73	244	166200	133348	46386270
Malignant neoplasm progression	68.70	9.73	78	166366	64848	46454770
Gastrointestinal haemorrhage	67.60	9.73	107	166337	77266	46442352
Pleural effusion	67.59	9.73	120	166324	82832	46436786
Disease progression	67.48	9.73	140	166304	91160	46428458
Hand deformity	66.92	9.73	20	166424	34554	46485064
Epilepsy	66.44	9.73	211	166233	23527	46496091
Multiple sclerosis relapse	66.38	9.73	312	166132	41813	46477805
Hypersomnia	64.74	9.73	159	166285	15280	46504338
Balance disorder	64.21	9.73	422	166022	64099	46455519
Bradyphrenia	63.84	9.73	94	166350	6136	46513482
Akathisia	63.19	9.73	105	166339	7609	46512009
Plasma cell myeloma	62.16	9.73	41	166403	44437	46475181
Arthralgia	61.97	9.73	921	165523	363682	46155936
Nightmare	61.37	9.73	163	166281	16435	46503183
Product substitution issue	61.13	9.73	153	166291	14878	46504740
Renal impairment	61.13	9.73	107	166337	74265	46445353
General physical health deterioration	60.96	9.73	210	166234	115559	46404059
Serotonin syndrome	60.38	9.73	207	166237	24013	46495605
Mucosal inflammation	58.55	9.73	33	166411	38943	46480675
Lactic acidosis	58.12	9.73	24	166420	33885	46485733
Bipolar disorder	57.87	9.73	97	166347	7080	46512538
Cardiac failure congestive	56.43	9.73	155	166289	91595	46428023
Drooling	54.23	9.73	62	166382	3147	46516471
Maternal exposure during pregnancy	53.33	9.73	187	166257	102362	46417256
Glossodynia	52.99	9.73	48	166396	44325	46475293
Bone marrow failure	52.49	9.73	20	166424	29649	46489969
Hallucination, auditory	51.88	9.73	117	166327	10639	46508979
Respiratory depression	51.36	9.73	122	166322	11478	46508140
Arthropathy	50.67	9.73	145	166299	84555	46435063
Myocardial stunning	49.98	9.73	20	166424	155	46519463
Status epilepticus	49.39	9.73	135	166309	13844	46505774
Drug screen negative	49.05	9.73	25	166419	358	46519260
Hypersensitivity	48.50	9.73	325	166119	149996	46369622
Haemoglobin decreased	48.30	9.73	266	166178	128683	46390935
Mood swings	47.82	9.73	147	166297	16105	46503513
Muscle rigidity	47.65	9.73	108	166336	9853	46509765
Granulocytopenia	46.21	9.73	74	166370	5199	46514419
Peripheral swelling	46.03	9.73	352	166092	157719	46361899
Dysarthria	46.02	9.73	259	166185	37239	46482379
Mydriasis	45.65	9.73	110	166334	10443	46509175
Feeling of despair	45.11	9.73	43	166401	1762	46517856
Swelling	44.93	9.73	260	166184	124251	46395367
Off label use	44.89	9.73	1022	165422	378819	46140799
Alopecia	44.82	9.73	367	166077	162047	46357571
Multiple sclerosis	44.60	9.73	191	166253	24600	46495018
Herpes zoster	43.75	9.73	112	166332	67760	46451858
Blood creatinine increased	43.39	9.73	134	166310	76269	46443349
Platelet count decreased	43.37	9.73	196	166248	99828	46419790
Restlessness	43.14	9.73	193	166251	25331	46494287
Stomatitis	43.03	9.73	114	166330	68183	46451435
Vision blurred	42.50	9.73	453	165991	79255	46440363
Exposure via ingestion	42.49	9.73	57	166387	3410	46516208
Renal failure	42.17	9.73	235	166209	113359	46406259
Therapeutic response unexpected	42.06	9.73	137	166307	15479	46504139
Lower respiratory tract infection	41.95	9.73	83	166361	55006	46464612
Palmar-plantar erythrodysaesthesia syndrome	41.12	9.73	11	166433	20440	46499178
Melaena	41.02	9.73	24	166420	27748	46491870
Bradykinesia	40.87	9.73	60	166384	3906	46515712
Lethargy	40.64	9.73	317	166127	50854	46468764
Delusion	40.48	9.73	109	166335	11079	46508539
Myocardial depression	39.83	9.73	24	166420	484	46519134
Dysphoria	39.66	9.73	64	166380	4525	46515093
Personality disorder	39.15	9.73	52	166392	3081	46516537
Osteonecrosis of jaw	38.99	9.73	39	166405	34363	46485255
Decorticate posture	38.98	9.73	21	166423	339	46519279
Loss of consciousness	38.73	9.73	571	165873	107667	46411951
Angioedema	38.71	9.73	50	166394	39292	46480326
Confusional state	38.64	9.73	792	165652	159100	46360518
Sluggishness	38.62	9.73	64	166380	4627	46514991
Substance abuse	38.62	9.73	60	166384	4107	46515511
Gastric pH decreased	38.33	9.73	21	166423	351	46519267
Hyperkalaemia	38.10	9.73	77	166367	50632	46468986
Parkinsonism	37.82	9.73	86	166358	7862	46511756
Hyponatraemia	36.33	9.73	212	166232	101120	46418498
Pericarditis	36.31	9.73	20	166424	23907	46495711
Head injury	36.30	9.73	179	166265	24457	46495161
Depressed mood	36.27	9.73	223	166221	33096	46486522
Panic disorder	35.91	9.73	45	166399	2516	46517102
Breast hyperplasia	35.49	9.73	18	166426	255	46519363
Atonic seizures	35.45	9.73	24	166420	596	46519022
Impaired driving ability	35.28	9.73	58	166386	4166	46515452
Pneumocystis jirovecii pneumonia	35.15	9.73	6	166438	15242	46504376
Psychomotor hyperactivity	35.13	9.73	94	166350	9519	46510099
Drug interaction	35.00	9.73	960	165484	202134	46317484
Abdominal discomfort	35.00	9.73	357	166087	150808	46368810
Major depression	34.78	9.73	75	166369	6615	46513003
Pulmonary arterial hypertension	34.76	9.73	25	166419	25903	46493715
Dissociation	34.69	9.73	38	166406	1839	46517779
Myocardial infarction	34.46	9.73	205	166239	97323	46422295
Jaundice cholestatic	34.11	9.73	63	166381	4966	46514652
Leukopenia	33.95	9.73	127	166317	68216	46451402
Neutrophil count decreased	33.43	9.73	65	166379	43361	46476257
Gait disturbance	33.29	9.73	714	165730	144549	46375069
Catatonia	33.25	9.73	53	166391	3709	46515909
Coma	33.17	9.73	336	166108	58013	46461605
Abnormal dreams	33.11	9.73	96	166348	10183	46509435
Emotional disorder	33.08	9.73	108	166336	12216	46507402
Hypercalcaemia	32.80	9.73	17	166427	21029	46498589
Cogwheel rigidity	32.59	9.73	33	166411	1457	46518161
Stress	32.32	9.73	303	166141	51248	46468370
Adjustment disorder with mixed anxiety and depressed mood	32.31	9.73	12	166432	74	46519544
Septic shock	31.84	9.73	103	166341	57790	46461828
Coma blister	31.80	9.73	14	166430	141	46519477
Electrocardiogram QT prolonged	30.85	9.73	299	166145	51026	46468592
Cytomegalovirus infection	30.84	9.73	13	166431	18131	46501487
Mental status changes	30.82	9.73	237	166207	37851	46481767
Road traffic accident	30.65	9.73	166	166278	23525	46496093
Anaphylactic reaction	30.26	9.73	93	166351	53019	46466599
Cognitive disorder	30.12	9.73	230	166214	36653	46482965
Autonomic nervous system imbalance	29.91	9.73	40	166404	2386	46517232
Product complaint	29.79	9.73	103	166341	11998	46507620
Disorientation	29.47	9.73	229	166215	36689	46482929
Vomiting	29.09	9.73	1319	165125	451475	46068143
Galactorrhoea	28.87	9.73	50	166394	3747	46515871
Bruxism	28.74	9.73	44	166400	2973	46516645
Hypocalcaemia	28.52	9.73	32	166412	26753	46492865
Developmental glaucoma	28.19	9.73	10	166434	53	46519565
Drug screen positive	27.98	9.73	50	166394	3841	46515777
Drug use disorder	27.64	9.73	41	166403	2694	46516924
Incoherent	27.49	9.73	54	166390	4458	46515160
Skin ulcer	27.30	9.73	46	166398	32412	46487206
Device expulsion	27.10	9.73	35	166409	27507	46492111
Hyperprolactinaemia	26.87	9.73	42	166402	2890	46516728
Dopamine dysregulation syndrome	26.85	9.73	15	166429	261	46519357
Obsessive-compulsive disorder	26.65	9.73	44	166400	3171	46516447
Right ventricular failure	26.60	9.73	12	166432	16081	46503537
Migraine	26.46	9.73	373	166071	69653	46449965
Urinary bladder rupture	26.41	9.73	12	166432	131	46519487
Nystagmus	26.38	9.73	61	166383	5638	46513980
Muscle twitching	26.36	9.73	113	166331	14559	46505059
Pneumonia	26.27	9.73	1086	165358	375234	46144384
Muscle spasms	25.94	9.73	598	165846	122515	46397103
Affect lability	25.92	9.73	75	166369	7945	46511673
C-reactive protein increased	25.88	9.73	114	166330	58476	46461142
Pleurothotonus	25.84	9.73	26	166418	1139	46518479
Derealisation	25.73	9.73	22	166422	781	46518837
Fear	25.63	9.73	120	166324	16052	46503566
Anticonvulsant drug level above therapeutic	25.44	9.73	18	166426	481	46519137
Electroencephalogram abnormal	25.42	9.73	47	166397	3707	46515911
Persecutory delusion	25.39	9.73	38	166406	2517	46517101
Upper gastrointestinal haemorrhage	25.38	9.73	14	166430	16724	46502894
Multiple-drug resistance	25.28	9.73	38	166406	2527	46517091
Fall	25.06	9.73	1423	165021	327674	46191944
Sleep disorder	24.95	9.73	266	166178	46529	46473089
Oromandibular dystonia	24.87	9.73	17	166427	429	46519189
On and off phenomenon	24.81	9.73	33	166411	1958	46517660
Extrapyramidal disorder	24.41	9.73	92	166352	11176	46508442
Hyperbilirubinaemia	24.30	9.73	4	166440	10434	46509184
Acute myeloid leukaemia	24.21	9.73	13	166431	15765	46503853
Neoplasm progression	24.16	9.73	36	166408	26647	46492971
Jaundice	24.15	9.73	41	166403	28804	46490814
Erythema	24.09	9.73	361	166083	142459	46377159
Transplant rejection	23.91	9.73	3	166441	9593	46510025
Urticaria	23.87	9.73	287	166157	117605	46402013
Ascites	23.86	9.73	60	166384	36524	46483094
Dizziness	23.84	9.73	1461	164983	338953	46180665
Proteinuria	23.47	9.73	15	166429	16538	46503080
Mutism	23.47	9.73	26	166418	1274	46518344
Middle insomnia	23.43	9.73	81	166363	9434	46510184
Nasopharyngitis	23.39	9.73	397	166047	153601	46366017
Fluid overload	23.35	9.73	38	166406	27147	46492471
Head titubation	23.27	9.73	19	166425	632	46518986
Generalised tonic-clonic seizure	23.20	9.73	171	166273	26951	46492667
Movement disorder	23.12	9.73	120	166324	16729	46502889
Apathy	22.57	9.73	67	166377	7201	46512417
Psychomotor retardation	22.56	9.73	41	166403	3192	46516426
Anorgasmia	22.53	9.73	18	166426	580	46519038
Rubber sensitivity	22.52	9.73	29	166415	1667	46517951
Formication	22.49	9.73	46	166398	3910	46515708
Aspiration	22.49	9.73	80	166364	9451	46510167
Metastases to liver	22.42	9.73	22	166422	19563	46500055
Hereditary angioedema	22.27	9.73	56	166388	5460	46514158
Band neutrophil percentage increased	22.04	9.73	12	166432	198	46519420
Pneumonia aspiration	21.45	9.73	189	166255	31416	46488202
Pulmonary fibrosis	21.40	9.73	24	166420	20068	46499550
Miosis	21.27	9.73	62	166382	6595	46513023
Pyrexia	21.17	9.73	1022	165422	347780	46171838
Seizure cluster	21.07	9.73	11	166433	166	46519452
Dependence	21.04	9.73	30	166414	1901	46517717
Coordination abnormal	20.97	9.73	86	166358	10863	46508755
Conversion disorder	20.94	9.73	28	166416	1670	46517948
Incontinence	20.94	9.73	80	166364	9782	46509836
Hostility	20.83	9.73	25	166419	1337	46518281
Hypokalaemia	20.72	9.73	207	166237	87817	46431801
Peritonitis	20.71	9.73	26	166418	20688	46498930
Pneumonitis	20.63	9.73	44	166400	28376	46491242
Helicobacter infection	20.61	9.73	8	166436	11728	46507890
Tension	20.59	9.73	37	166407	2855	46516763
Pulmonary hypertension	20.52	9.73	63	166381	35930	46483688
Hypertension	20.48	9.73	538	165906	195818	46323800
Weight abnormal	20.43	9.73	21	166423	944	46518674
Knee arthroplasty	20.40	9.73	33	166411	23632	46495986
Tachyphrenia	20.19	9.73	24	166420	1270	46518348
Broncholithiasis	20.16	9.73	9	166435	94	46519524
Neuropathy peripheral	20.07	9.73	217	166227	90676	46428942
Panic reaction	19.92	9.73	42	166402	3647	46515971
Urinary retention	19.89	9.73	160	166284	25901	46493717
Epistaxis	19.74	9.73	141	166303	64164	46455454
Anaphylactic shock	19.70	9.73	26	166418	20248	46499370
Wound	19.68	9.73	82	166362	42720	46476898
Rash pruritic	19.54	9.73	86	166358	44129	46475489
Exposure during pregnancy	19.48	9.73	270	166174	107942	46411676
Diverticulitis	19.43	9.73	57	166387	32982	46486636
Cerebellar atrophy	19.40	9.73	17	166427	624	46518994
Prescribed overdose	19.17	9.73	81	166363	10368	46509250
Nausea	19.16	9.73	2153	164291	685301	45834317
White blood cell count decreased	19.15	9.73	283	166161	111948	46407670
Neutropenic sepsis	19.14	9.73	10	166434	12314	46507304
Bone erosion	19.13	9.73	5	166439	9438	46510180
Hypomagnesaemia	19.12	9.73	31	166413	22179	46497439
Fibromyalgia	18.85	9.73	206	166238	36257	46483361
Drug ineffective	18.74	9.73	2124	164320	675714	45843904
Hypokinesia	18.67	9.73	85	166359	11237	46508381
Liver function test increased	18.60	9.73	33	166411	22793	46496825
Cough	18.56	9.73	653	165791	229596	46290022
Libido increased	18.56	9.73	18	166426	754	46518864
Myelocyte percentage increased	18.53	9.73	10	166434	162	46519456
Stereotypy	18.53	9.73	14	166430	415	46519203
Food craving	18.50	9.73	22	166422	1165	46518453
Intellectual disability	18.49	9.73	17	166427	665	46518953
International normalised ratio increased	18.49	9.73	95	166349	46788	46472830
Aphasia	18.45	9.73	169	166275	28398	46491220
Liver function test abnormal	18.44	9.73	94	166350	46393	46473225
Therapeutic product effect decreased	18.32	9.73	197	166247	82404	46437214
Bipolar I disorder	18.31	9.73	25	166419	1521	46518097
Suicidal behaviour	18.31	9.73	32	166412	2416	46517202
Anticonvulsant drug level below therapeutic	18.24	9.73	16	166428	588	46519030
Antidepressant drug level above therapeutic	18.22	9.73	13	166431	352	46519266
Full blood count decreased	18.20	9.73	32	166412	22179	46497439
Acute myocardial infarction	18.11	9.73	56	166388	31868	46487750
Antipsychotic drug level increased	18.01	9.73	37	166407	3155	46516463
Abdominal pain	17.94	9.73	655	165789	229376	46290242
Depersonalisation/derealisation disorder	17.89	9.73	20	166424	990	46518628
Circulatory collapse	17.86	9.73	31	166413	21593	46498025
Disseminated intravascular coagulation	17.84	9.73	25	166419	18980	46500638
Dysstasia	17.83	9.73	116	166328	17552	46502066
Osteonecrosis	17.75	9.73	41	166403	25703	46493915
Musculoskeletal pain	17.74	9.73	162	166282	69966	46449652
Drug abuser	17.68	9.73	37	166407	3196	46516422
Weight gain poor	17.55	9.73	17	166427	711	46518907
Colitis	17.52	9.73	71	166373	37276	46482342
Impulsive behaviour	17.20	9.73	24	166420	1491	46518127
Tongue discolouration	17.16	9.73	35	166409	2969	46516649
Libido decreased	16.88	9.73	32	166412	2573	46517045
Hypothermia	16.88	9.73	87	166357	12096	46507522
Screaming	16.85	9.73	36	166408	3155	46516463
Haematuria	16.78	9.73	45	166399	26813	46492805
Stoma site discharge	16.69	9.73	27	166417	1913	46517705
Change in seizure presentation	16.69	9.73	11	166433	261	46519357
Shock haemorrhagic	16.67	9.73	5	166439	8619	46510999
Cerebral haemorrhage	16.64	9.73	49	166395	28322	46491296
Drug tolerance	16.64	9.73	36	166408	3182	46516436
Hepatocellular injury	16.59	9.73	52	166392	29470	46490148
Coronary artery disease	16.57	9.73	63	166381	33689	46485929
Dysgraphia	16.51	9.73	33	166411	2759	46516859
Peripheral pulse decreased	16.44	9.73	6	166438	35	46519583
Mitral valve thickening	16.29	9.73	6	166438	36	46519582
Tic	16.20	9.73	21	166423	1215	46518403
H1N1 influenza	16.09	9.73	23	166421	1461	46518157
Urinary incontinence	16.07	9.73	164	166280	28366	46491252
Injection site pruritus	15.97	9.73	80	166364	39663	46479955
Cytopenia	15.96	9.73	4	166440	7764	46511854
Polycystic ovaries	15.82	9.73	22	166422	1362	46518256
Thrombotic microangiopathy	15.72	9.73	5	166439	8301	46511317
Myoclonus	15.58	9.73	96	166348	14256	46505362
Blood triglycerides increased	15.53	9.73	83	166361	11700	46507918
Electrocardiogram QRS complex shortened	15.48	9.73	12	166432	370	46519248
Psychiatric symptom	15.46	9.73	43	166401	4454	46515164
Lymph node calcification	15.41	9.73	9	166435	171	46519447
Oliguria	15.33	9.73	6	166438	8753	46510865
Haematemesis	15.32	9.73	52	166392	28754	46490864
Social anxiety disorder	15.28	9.73	12	166432	377	46519241
Dysphagia	15.20	9.73	372	166072	76940	46442678
Cerebrovascular accident	15.16	9.73	261	166183	100778	46418840
Metabolic acidosis	15.05	9.73	79	166365	38701	46480917
Schizoaffective disorder	15.01	9.73	22	166422	1430	46518188
Disorganised speech	15.01	9.73	17	166427	854	46518764
Hip arthroplasty	14.93	9.73	26	166418	18086	46501532
Drug ineffective for unapproved indication	14.91	9.73	105	166339	16308	46503310
Pupil fixed	14.88	9.73	24	166420	1696	46517922
Oedema	14.85	9.73	160	166284	66911	46452707
Emotional distress	14.75	9.73	171	166273	30536	46489082
Initial insomnia	14.75	9.73	42	166402	4410	46515208
Impaired healing	14.74	9.73	74	166370	36669	46482949
Cholestasis	14.68	9.73	48	166396	26845	46492773
Blood growth hormone increased	14.67	9.73	12	166432	400	46519218
Dehydration	14.62	9.73	445	165999	159095	46360523
Motor dysfunction	14.59	9.73	58	166386	7224	46512394
Femur fracture	14.57	9.73	75	166369	36922	46482696
Menstrual disorder	14.47	9.73	40	166404	4128	46515490
Attention deficit hyperactivity disorder	14.47	9.73	27	166417	2145	46517473
Sensitisation	14.45	9.73	15	166429	682	46518936
Hyperkeratosis	14.36	9.73	45	166399	4980	46514638
Rash maculo-papular	14.36	9.73	51	166393	27823	46491795
Intervertebral disc protrusion	14.35	9.73	123	166321	20282	46499336
Right ventricular systolic pressure decreased	14.33	9.73	5	166439	25	46519593
Flight of ideas	14.25	9.73	11	166433	337	46519281
Fluid retention	14.22	9.73	115	166329	50931	46468687
Ketosis-prone diabetes mellitus	14.20	9.73	4	166440	8	46519610
Diplopia	14.19	9.73	118	166326	19287	46500331
Congenital knee deformity	14.17	9.73	5	166439	26	46519592
Influenza like illness	14.16	9.73	286	166158	57284	46462334
Abulia	14.11	9.73	11	166433	342	46519276
Logorrhoea	14.09	9.73	28	166416	2331	46517287
Bradycardia neonatal	14.05	9.73	14	166430	606	46519012
Feeling of body temperature change	13.97	9.73	40	166404	4212	46515406
Bacteraemia	13.97	9.73	18	166426	14161	46505457
Tonic clonic movements	13.96	9.73	19	166425	1153	46518465
Oculocephalogyric reflex absent	13.92	9.73	3	166441	0	46519618
Periorbital swelling	13.90	9.73	20	166424	1278	46518340
Multiple organ dysfunction syndrome	13.72	9.73	118	166326	51592	46468026
Pericardial effusion	13.66	9.73	46	166398	25497	46494121
Blepharospasm	13.59	9.73	27	166417	2247	46517371
Blood prolactin increased	13.58	9.73	32	166412	2995	46516623
Coma scale abnormal	13.55	9.73	44	166400	4962	46514656
Metastases to lung	13.46	9.73	11	166433	10685	46508933
Clumsiness	13.38	9.73	23	166421	1713	46517905
Self-injurious ideation	13.38	9.73	27	166417	2273	46517345
Tubulointerstitial nephritis	13.34	9.73	20	166424	14768	46504850
Nephrogenic diabetes insipidus	13.33	9.73	15	166429	748	46518870
Periodic limb movement disorder	13.29	9.73	8	166436	161	46519457
COVID-19	13.28	9.73	29	166415	18546	46501072
Heart rate abnormal	13.27	9.73	34	166410	3353	46516265
Post-traumatic stress disorder	13.22	9.73	38	166406	4010	46515608
Oculogyric crisis	13.21	9.73	19	166425	1214	46518404
Hyperreflexia	13.17	9.73	45	166399	5209	46514409
Pruritus	13.17	9.73	718	165726	241634	46277984
Upper respiratory tract infection	13.13	9.73	154	166290	63402	46456216
Haematochezia	13.13	9.73	79	166365	37414	46482204
Inflammation	13.08	9.73	111	166333	48670	46470948
Haemoglobin urine	12.99	9.73	7	166437	113	46519505
Injection site erythema	12.93	9.73	187	166257	74240	46445378
Sebaceous gland infection	12.88	9.73	7	166437	115	46519503
Distractibility	12.88	9.73	10	166434	309	46519309
Suspected product quality issue	12.87	9.73	8	166436	171	46519447
Compulsive shopping	12.83	9.73	15	166429	780	46518838
Tinnitus	12.80	9.73	153	166291	27520	46492098
Ejection fraction	12.75	9.73	13	166431	579	46519039
Decreased interest	12.73	9.73	32	166412	3120	46516498
Tearfulness	12.73	9.73	38	166406	4097	46515521
Acute generalised exanthematous pustulosis	12.70	9.73	9	166435	9396	46510222
Prescribed underdose	12.70	9.73	80	166364	11973	46507645
Pathogen resistance	12.68	9.73	3	166441	6057	46513561
Hepatic enzyme increased	12.68	9.73	210	166234	81577	46438041
Therapeutic product effect incomplete	12.67	9.73	199	166245	77954	46441664
Parkinsonian gait	12.65	9.73	12	166432	489	46519129
Myoclonic epilepsy	12.60	9.73	16	166428	907	46518711
Victim of crime	12.56	9.73	6	166438	74	46519544
Parasomnia	12.55	9.73	11	166433	404	46519214
Peroneal nerve palsy	12.54	9.73	38	166406	4130	46515488
Anticonvulsant drug level increased	12.54	9.73	20	166424	1400	46518218
Flat affect	12.46	9.73	19	166425	1279	46518339
Gaze palsy	12.46	9.73	19	166425	1279	46518339
Drop attacks	12.46	9.73	14	166430	697	46518921
Choking	12.44	9.73	61	166383	8315	46511303
Heart rate increased	12.42	9.73	352	166092	74439	46445179
Cellulitis	12.42	9.73	176	166268	70112	46449506
Colitis ulcerative	12.42	9.73	28	166416	17704	46501914
Hyperammonaemic encephalopathy	12.41	9.73	24	166420	1958	46517660
Barotrauma	12.39	9.73	8	166436	183	46519435
Sensorimotor disorder	12.39	9.73	11	166433	411	46519207
Congenital jaw malformation	12.38	9.73	4	166440	15	46519603
Narcotic bowel syndrome	12.37	9.73	7	166437	125	46519493
Hyperammonaemia	12.36	9.73	41	166403	4675	46514943
Cerebral atrophy	12.36	9.73	41	166403	4675	46514943
Abscess	12.32	9.73	19	166425	13870	46505748
Band neutrophil count increased	12.26	9.73	10	166434	332	46519286
Sleep-related eating disorder	12.26	9.73	13	166431	606	46519012
Enuresis	12.26	9.73	24	166420	1976	46517642
Staphylococcal infection	12.20	9.73	76	166368	35695	46483923
Pulmonary haemorrhage	12.16	9.73	4	166440	6501	46513117
Stoma site pain	12.10	9.73	17	166427	1063	46518555
Colitis ischaemic	12.05	9.73	11	166433	10121	46509497
Ischaemic stroke	12.04	9.73	26	166418	16696	46502922
Urine oxalate increased	11.98	9.73	8	166436	194	46519424
Euphoric mood	11.98	9.73	38	166406	4234	46515384
Freezing phenomenon	11.96	9.73	20	166424	1457	46518161
Cholelithiasis	11.90	9.73	199	166245	38482	46481136
Specific gravity urine decreased	11.89	9.73	11	166433	434	46519184
Increased appetite	11.89	9.73	61	166383	8466	46511152
Salivary hypersecretion	11.86	9.73	50	166394	6395	46513223
Aerophagia	11.85	9.73	3	166441	3	46519615
Large intestine operation	11.85	9.73	3	166441	3	46519615
Drug detoxification	11.84	9.73	8	166436	198	46519420
Transfusion	11.83	9.73	18	166426	13213	46506405
Bronchopulmonary aspergillosis	11.76	9.73	6	166438	7490	46512128
Dysphemia	11.76	9.73	26	166418	2332	46517286
Suspected suicide	11.76	9.73	40	166404	4621	46514997
Drug screen false positive	11.65	9.73	15	166429	862	46518756
Klebsiella test positive	11.63	9.73	16	166428	981	46518637
Clostridium difficile infection	11.60	9.73	48	166396	25055	46494563
Adrenal insufficiency	11.60	9.73	18	166426	13106	46506512
Post-traumatic neck syndrome	11.58	9.73	19	166425	1362	46518256
Essential tremor	11.57	9.73	14	166430	755	46518863
Feeling jittery	11.55	9.73	73	166371	10935	46508683
Coagulopathy	11.55	9.73	31	166413	18468	46501150
Monocyte count abnormal	11.53	9.73	8	166436	207	46519411
Homicidal ideation	11.51	9.73	22	166422	1780	46517838
Arthritis	11.50	9.73	200	166244	77116	46442502
Trismus	11.49	9.73	33	166411	3482	46516136
Dairy intolerance	11.48	9.73	5	166439	49	46519569
Fractured coccyx	11.46	9.73	16	166428	994	46518624
Soft tissue haemorrhage	11.40	9.73	8	166436	211	46519407
Acute hepatic failure	11.36	9.73	22	166422	14699	46504919
Sleep terror	11.35	9.73	14	166430	770	46518848
Binge eating	11.35	9.73	10	166434	370	46519248
Feeling drunk	11.29	9.73	35	166409	3852	46515766
Lupus-like syndrome	11.27	9.73	7	166437	7837	46511781
Feelings of worthlessness	11.24	9.73	9	166435	291	46519327
Eating disorder	11.20	9.73	90	166354	14564	46505054
Cast application	11.15	9.73	4	166440	22	46519596
Metastases to bone	11.13	9.73	29	166415	17447	46502171
Concussion	11.12	9.73	52	166392	6951	46512667
Family stress	11.12	9.73	12	166432	571	46519047
Laryngeal stenosis	11.10	9.73	13	166431	677	46518941
Coagulation factor VII level decreased	11.00	9.73	4	166440	23	46519595
Hyperacusis	10.98	9.73	22	166422	1842	46517776
Gastrointestinal disorder	10.95	9.73	148	166296	59428	46460190
Stoma site hypergranulation	10.89	9.73	11	166433	484	46519134
Impulse-control disorder	10.89	9.73	13	166431	691	46518927
Sleep apnoea syndrome	10.82	9.73	124	166320	22077	46497541
Injection site pain	10.79	9.73	295	166149	106857	46412761
Anuria	10.76	9.73	15	166429	11416	46508202
Altered state of consciousness	10.76	9.73	129	166315	23219	46496399
Haemorrhage intracranial	10.73	9.73	18	166426	12706	46506912
Haematoma	10.72	9.73	68	166376	31804	46487814
Foetal growth restriction	10.69	9.73	5	166439	6562	46513056
Psychogenic seizure	10.63	9.73	17	166427	1193	46518425
Chronic papillomatous dermatitis	10.59	9.73	5	166439	60	46519558
Adverse drug reaction	10.57	9.73	104	166340	44258	46475360
Drug level above therapeutic	10.57	9.73	32	166412	3477	46516141
Reduced facial expression	10.52	9.73	17	166427	1203	46518415
Automatism	10.52	9.73	5	166439	61	46519557
Chronic kidney disease	10.52	9.73	94	166350	40777	46478841
Hypoaesthesia oral	10.46	9.73	69	166375	10490	46509128
Thrombosis	10.41	9.73	139	166305	55930	46463688
Blood ethanol increased	10.38	9.73	5	166439	63	46519555
Bone decalcification	10.34	9.73	4	166440	28	46519590
Temperature intolerance	10.31	9.73	54	166390	7553	46512065
Pancreatolithiasis	10.31	9.73	8	166436	247	46519371
Poor quality sleep	10.24	9.73	91	166353	15162	46504456
Haematotoxicity	10.22	9.73	6	166438	6927	46512691
Basal cell carcinoma	10.21	9.73	38	166406	20449	46499169
Alcohol poisoning	10.20	9.73	24	166420	2244	46517374
Nephrectomy	10.18	9.73	11	166433	524	46519094
Affective disorder	10.17	9.73	39	166405	4776	46514842
Subarachnoid haemorrhage	10.14	9.73	15	166429	11138	46508480
Hypoventilation	10.13	9.73	35	166409	4075	46515543
Hypnopompic hallucination	10.11	9.73	4	166440	30	46519588
Localised infection	10.09	9.73	47	166397	23754	46495864
Infantile spasms	10.09	9.73	8	166436	255	46519363
Breast cancer metastatic	10.08	9.73	21	166423	13657	46505961
Myelodysplastic syndrome	10.06	9.73	26	166418	15685	46503933
Obsessive-compulsive symptom	10.00	9.73	4	166440	31	46519587
Somnambulism	9.99	9.73	40	166404	4997	46514621
Body height increased	9.97	9.73	5	166439	69	46519549
Respiratory rate decreased	9.97	9.73	29	166415	3081	46516537
Therapeutic product ineffective	9.96	9.73	15	166429	999	46518619
Oral pain	9.91	9.73	50	166394	24747	46494871
Homeless	9.89	9.73	4	166440	32	46519586
Toxic leukoencephalopathy	9.88	9.73	11	166433	542	46519076
Soliloquy	9.86	9.73	7	166437	188	46519430
Cushingoid	9.86	9.73	5	166439	6261	46513357
Myelocyte count increased	9.83	9.73	9	166435	350	46519268
Epstein-Barr virus infection	9.82	9.73	6	166438	6778	46512840
Arthritis infective	9.82	9.73	3	166441	5110	46514508
Electrocardiogram QRS complex prolonged	9.81	9.73	42	166402	5407	46514211
Narcolepsy	9.79	9.73	16	166428	1143	46518475
Muscle contractions involuntary	9.79	9.73	22	166422	1996	46517622
Alcohol abuse	9.78	9.73	23	166421	2149	46517469
Retinal detachment	9.78	9.73	3	166441	5097	46514521
Hospitalisation	9.74	9.73	163	166281	63222	46456396
Cytokine release syndrome	9.74	9.73	5	166439	6218	46513400

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	829.36	10.36	1116	87895	80956	29782511
Completed suicide	709.09	10.36	1148	87863	98344	29765123
Toxicity to various agents	520.83	10.36	1421	87590	175762	29687705
Depression	467.28	10.36	907	88104	89530	29773937
Sopor	287.67	10.36	248	88763	10743	29852724
Somnolence	282.27	10.36	775	88236	95988	29767479
Anxiety	266.27	10.36	724	88287	89147	29774320
Overdose	256.44	10.36	686	88325	83651	29779816
Seizure	244.01	10.36	744	88267	97731	29765736
Intentional overdose	221.10	10.36	422	88589	41059	29822408
Respiratory arrest	220.58	10.36	347	88664	28911	29834556
Neuroleptic malignant syndrome	205.74	10.36	248	88763	16047	29847420
Suicide attempt	203.83	10.36	380	88631	36317	29827150
Sedation	176.10	10.36	230	88781	16143	29847324
Agitation	175.59	10.36	451	88560	53622	29809845
Suicidal ideation	170.21	10.36	349	88662	35765	29827702
Aggression	160.36	10.36	345	88666	36562	29826905
Intentional self-injury	151.64	10.36	194	88817	13338	29850129
Cardio-respiratory arrest	147.42	10.36	439	88572	56867	29806600
Intentional product misuse	139.21	10.36	314	88697	34353	29829114
Coma	138.19	10.36	344	88667	40105	29823362
Anaemia	137.18	10.36	256	88755	207736	29655731
Febrile neutropenia	135.72	10.36	74	88937	106619	29756848
Psychotic disorder	129.82	10.36	231	88780	21284	29842183
Drug withdrawal syndrome	127.73	10.36	219	88792	19590	29843877
Acute kidney injury	125.02	10.36	408	88603	273434	29590033
Drug interaction	122.85	10.36	1012	87999	198556	29664911
Drug dependence	118.79	10.36	221	88790	21074	29842393
Abnormal behaviour	116.45	10.36	244	88767	25379	29838088
Status epilepticus	113.59	10.36	152	88859	10920	29852547
Poisoning	104.35	10.36	148	88863	11234	29852233
Dyspnoea	103.76	10.36	575	88436	332720	29530747
Substance abuse	103.66	10.36	116	88895	6924	29856543
Insomnia	102.93	10.36	548	88463	92788	29770679
Interstitial lung disease	102.88	10.36	26	88985	60171	29803296
Dyskinesia	98.14	10.36	207	88804	21627	29841840
Panic attack	94.96	10.36	123	88888	8558	29854909
Cardiac arrest	91.59	10.36	529	88482	92321	29771146
Speech disorder	90.66	10.36	215	88796	24297	29839170
Depressed level of consciousness	88.18	10.36	282	88729	37940	29825527
Parkinsonism	87.46	10.36	108	88903	7161	29856306
Thrombocytopenia	84.75	10.36	175	88836	136869	29726598
Pancytopenia	84.40	10.36	77	88934	84975	29778492
Diarrhoea	81.24	10.36	621	88390	333482	29529985
Granulocytopenia	80.60	10.36	96	88915	6130	29857337
Sepsis	77.62	10.36	203	88808	146192	29717275
Malignant neoplasm progression	77.16	10.36	61	88950	72226	29791241
Ataxia	76.89	10.36	129	88882	11333	29852134
Hallucination	75.18	10.36	317	88694	48742	29814725
Paranoia	74.20	10.36	119	88892	10069	29853398
Dystonia	74.14	10.36	116	88895	9611	29853856
Drug withdrawal convulsions	74.10	10.36	45	88966	1114	29862353
Miosis	74.08	10.36	103	88908	7673	29855794
Renal failure	71.31	10.36	175	88836	128791	29734676
Serotonin syndrome	69.51	10.36	160	88851	17731	29845736
Akathisia	68.27	10.36	86	88925	5818	29857649
Cardiac failure	66.85	10.36	90	88921	83328	29780139
Pneumonia	66.69	10.36	654	88357	333652	29529815
Myocardial infarction	65.96	10.36	175	88836	125450	29738017
Salivary hypersecretion	65.86	10.36	96	88915	7470	29855997
Restlessness	65.68	10.36	181	88830	22418	29841049
Thinking abnormal	65.65	10.36	80	88931	5231	29858236
Tremor	64.53	10.36	414	88597	74949	29788518
Muscle rigidity	64.24	10.36	112	88899	10149	29853318
Rash	62.86	10.36	325	88686	191564	29671903
Hallucination, auditory	60.19	10.36	106	88905	9683	29853784
Hyperkalaemia	59.47	10.36	65	88946	65945	29797522
Epilepsy	59.07	10.36	162	88849	20007	29843460
Psychomotor hyperactivity	58.45	10.36	95	88916	8129	29855338
Anger	57.79	10.36	112	88899	11008	29852459
Memory impairment	56.78	10.36	240	88771	36934	29826533
Disease progression	56.41	10.36	94	88917	79780	29783687
Generalised tonic-clonic seizure	55.25	10.36	155	88856	19396	29844071
Respiratory depression	55.13	10.36	112	88899	11391	29852076
Irritability	54.92	10.36	172	88839	22878	29840589
Bradykinesia	54.15	10.36	57	88954	3173	29860294
Pneumonia aspiration	53.94	10.36	239	88772	37541	29825926
Drug use disorder	53.89	10.36	57	88954	3191	29860276
Atrial fibrillation	53.48	10.36	155	88856	107969	29755498
Tardive dyskinesia	52.75	10.36	70	88941	4987	29858480
Pyrexia	52.59	10.36	591	88420	293898	29569569
Delusion	51.94	10.36	112	88899	11877	29851590
Platelet count decreased	51.86	10.36	153	88858	105976	29757491
Gastrointestinal haemorrhage	51.16	10.36	107	88904	83339	29780128
Plasma cell myeloma	51.14	10.36	50	88961	53412	29810055
Neutropenia	50.84	10.36	203	88808	128337	29735130
Housebound	50.82	10.36	20	88991	181	29863286
Disturbance in attention	50.77	10.36	163	88848	21966	29841501
Psychiatric decompensation	50.09	10.36	37	88974	1278	29862189
Gait disturbance	50.07	10.36	387	88624	74390	29789077
Nervousness	49.79	10.36	109	88902	11679	29851788
Pleural effusion	49.71	10.36	90	88921	73976	29789491
Renal impairment	49.08	10.36	111	88900	84073	29779394
Cardiac failure congestive	48.64	10.36	112	88899	84295	29779172
Confusional state	48.58	10.36	613	88398	134221	29729246
Cognitive disorder	47.71	10.36	167	88844	23523	29839944
Behaviour disorder	46.69	10.36	46	88965	2366	29861101
Mental disorder	46.54	10.36	115	88896	13334	29850133
Loss of personal independence in daily activities	46.16	10.36	155	88856	21380	29842087
Stomatitis	45.71	10.36	27	88984	37252	29826215
Cerebrovascular accident	44.76	10.36	115	88896	83362	29780105
Depression suicidal	44.38	10.36	34	88977	1242	29862225
Disorientation	44.27	10.36	198	88813	31220	29832247
Hyperprolactinaemia	44.00	10.36	33	88978	1167	29862300
Haemoglobin decreased	43.97	10.36	182	88829	113916	29749551
Catatonia	43.20	10.36	59	88952	4321	29859146
Device interaction	41.99	10.36	22	88989	406	29863061
Rheumatoid arthritis	41.19	10.36	37	88974	41160	29822307
Withdrawal syndrome	40.85	10.36	98	88913	11152	29852315
Psychomotor skills impaired	40.67	10.36	39	88972	1940	29861527
Dysarthria	40.62	10.36	189	88822	30301	29833166
General physical health deterioration	40.03	10.36	157	88854	99787	29763680
Drug abuser	40.00	10.36	57	88954	4344	29859123
Drooling	39.99	10.36	47	88964	2958	29860509
Tearfulness	39.70	10.36	35	88976	1561	29861906
Obsessive-compulsive disorder	39.67	10.36	55	88956	4086	29859381
Acute myocardial infarction	39.54	10.36	60	88951	52879	29810588
Disinhibition	39.15	10.36	38	88973	1919	29861548
Prescribed overdose	38.26	10.36	81	88930	8480	29854987
Joint swelling	38.25	10.36	50	88961	46896	29816571
Medication error	38.12	10.36	143	88868	20829	29842638
Agoraphobia	37.63	10.36	17	88994	223	29863244
Infusion related reaction	37.57	10.36	39	88972	40525	29822942
Altered state of consciousness	37.19	10.36	137	88874	19782	29843685
Mental impairment	37.17	10.36	84	88927	9193	29854274
Bradyphrenia	37.07	10.36	52	88959	3905	29859562
Mania	36.81	10.36	83	88928	9071	29854396
Angioedema	36.69	10.36	29	88982	34355	29829112
On and off phenomenon	36.47	10.36	44	88967	2847	29860620
Psychomotor retardation	36.40	10.36	40	88971	2339	29861128
Blood creatinine increased	36.29	10.36	144	88867	91231	29772236
Postmortem blood drug level increased	35.64	10.36	14	88997	126	29863341
Postmortem blood drug level abnormal	35.34	10.36	16	88995	211	29863256
Lactic acidosis	35.01	10.36	25	88986	31188	29832279
Infection	34.99	10.36	117	88894	77957	29785510
Oedema peripheral	34.72	10.36	179	88832	105653	29757814
Movement disorder	34.72	10.36	85	88926	9798	29853669
Bone marrow failure	34.54	10.36	23	88988	29762	29833705
Cough	34.04	10.36	226	88785	125416	29738051
Cytomegalovirus infection	33.77	10.36	14	88997	23660	29839807
Cerebral haemorrhage	33.53	10.36	29	88982	32858	29830609
Loss of consciousness	33.46	10.36	372	88639	79003	29784464
Blood creatine phosphokinase increased	33.36	10.36	234	88777	43614	29819853
Drug ineffective	33.24	10.36	1280	87731	339107	29524360
Unresponsive to stimuli	33.18	10.36	161	88850	26258	29837209
Screaming	32.73	10.36	29	88982	1302	29862165
Toxicologic test abnormal	32.16	10.36	21	88990	592	29862875
Mydriasis	32.07	10.36	62	88949	6081	29857386
Abnormal dreams	31.98	10.36	73	88938	8042	29855425
Fall	31.95	10.36	736	88275	181136	29682331
Drug hypersensitivity	31.87	10.36	101	88910	68418	29795049
Restless legs syndrome	31.86	10.36	66	88945	6806	29856661
Ascites	31.65	10.36	36	88975	35885	29827582
Myoclonus	31.39	10.36	99	88912	13213	29850254
Psychogenic seizure	31.24	10.36	16	88995	281	29863186
Coronary artery disease	31.08	10.36	63	88948	49649	29813818
Drug diversion	30.96	10.36	24	88987	892	29862575
Schizophrenia	30.92	10.36	77	88934	8971	29854496
Poor quality sleep	30.63	10.36	67	88944	7174	29856293
Feeling of despair	30.42	10.36	24	88987	916	29862551
Myelodysplastic syndrome	30.39	10.36	9	89002	18769	29844698
Choreoathetosis	30.35	10.36	24	88987	919	29862548
Decreased appetite	30.28	10.36	292	88719	149618	29713849
Melaena	30.25	10.36	31	88980	32406	29831061
Hallucination, visual	30.23	10.36	111	88900	16002	29847465
Urticaria	30.21	10.36	74	88937	54532	29808935
Nausea	30.16	10.36	663	88348	296294	29567173
Septic shock	30.11	10.36	93	88918	63514	29799953
Pneumocystis jirovecii pneumonia	30.00	10.36	7	89004	17113	29846354
Product substitution issue	29.77	10.36	81	88930	9954	29853513
Crying	29.76	10.36	57	88954	5552	29857915
Dyspnoea exertional	29.62	10.36	37	88974	35393	29828074
Illness anxiety disorder	29.58	10.36	13	88998	159	29863308
Vessel puncture site erythema	28.93	10.36	6	89005	0	29863467
Myoclonic epilepsy	28.70	10.36	22	88989	804	29862663
Contraindicated product administered	28.37	10.36	8	89003	17223	29846244
Generalised anxiety disorder	28.35	10.36	20	88991	642	29862825
Tension	28.15	10.36	29	88982	1574	29861893
Electroencephalogram abnormal	28.12	10.36	35	88976	2339	29861128
Multiple-drug resistance	28.08	10.36	39	88972	2902	29860565
Panic disorder	27.71	10.36	25	88986	1150	29862317
Drug screen positive	27.45	10.36	48	88963	4359	29859108
Sleep apnoea syndrome	27.43	10.36	111	88900	16746	29846721
Middle insomnia	27.41	10.36	56	88955	5717	29857750
Pruritus	27.04	10.36	223	88788	117981	29745486
Haematuria	27.03	10.36	58	88953	44776	29818691
Dystonic tremor	26.90	10.36	11	89000	111	29863356
Mucosal inflammation	26.39	10.36	31	88980	30463	29833004
Affect lability	26.37	10.36	41	88970	3377	29860090
Accidental overdose	26.36	10.36	116	88895	18159	29845308
Gastrointestinal hypermotility	26.23	10.36	11	89000	119	29863348
Bronchopulmonary aspergillosis	26.02	10.36	3	89008	12281	29851186
Bipolar disorder	25.99	10.36	43	88968	3733	29859734
Cerebral infarction	25.99	10.36	24	88987	26349	29837118
Blunted affect	25.98	10.36	14	88997	274	29863193
Dysphoria	25.97	10.36	32	88979	2116	29861351
Tachyphrenia	25.95	10.36	23	88988	1033	29862434
Drug tolerance	25.81	10.36	32	88979	2130	29861337
Depressive symptom	25.76	10.36	28	88983	1617	29861850
Proteinuria	25.66	10.36	8	89003	16137	29847330
Torticollis	25.60	10.36	23	88988	1052	29862415
Talipes	25.34	10.36	28	88983	1647	29861820
Postictal paralysis	25.14	10.36	11	89000	133	29863334
Blood creatine phosphokinase	24.99	10.36	9	89002	62	29863405
Erythema	24.83	10.36	132	88879	77319	29786148
Anaphylactic reaction	24.69	10.36	28	88983	27954	29835513
Weight increased	24.59	10.36	335	88676	74578	29788889
Stoma site discharge	24.30	10.36	26	88985	1475	29861992
Colitis	23.92	10.36	34	88977	30786	29832681
Bradypnoea	23.85	10.36	29	88982	1892	29861575
Drug level above therapeutic	23.73	10.36	36	88975	2903	29860564
Purpura fulminans	23.46	10.36	10	89001	113	29863354
Treatment failure	23.38	10.36	42	88969	34637	29828830
Multiple organ dysfunction syndrome	23.37	10.36	103	88908	63384	29800083
Atonic seizures	23.27	10.36	11	89000	161	29863306
Injection site exfoliation	22.71	10.36	6	89005	11	29863456
Withdrawal arrhythmia	22.57	10.36	7	89004	28	29863439
Hypotonia	22.56	10.36	58	88953	6890	29856577
Nightmare	22.49	10.36	83	88928	11993	29851474
International normalised ratio increased	22.45	10.36	70	88941	47669	29815798
Personality disorder	22.31	10.36	22	88989	1133	29862334
Amnesia	22.27	10.36	136	88875	24185	29839282
Acute myeloid leukaemia	22.13	10.36	13	88998	17993	29845474
Feeling abnormal	22.11	10.36	262	88749	56494	29806973
Injection site dryness	22.05	10.36	6	89005	13	29863454
Pulmonary fibrosis	21.71	10.36	10	89001	15880	29847587
Oedema	21.69	10.36	61	88950	42932	29820535
Gambling disorder	21.59	10.36	27	88984	1813	29861654
Drug screen negative	21.52	10.36	12	88999	252	29863215
Physical assault	21.40	10.36	22	88989	1191	29862276
Neutropenic sepsis	21.36	10.36	4	89007	11405	29852062
Ehlers-Danlos syndrome	21.31	10.36	7	89004	35	29863432
Balance disorder	21.23	10.36	183	88828	36310	29827157
Congenital melanocytic naevus	21.18	10.36	6	89005	16	29863451
Antidepressant drug level increased	21.17	10.36	9	89002	101	29863366
Post-traumatic stress disorder	21.06	10.36	25	88986	1590	29861877
Blood bilirubin increased	20.77	10.36	49	88962	36587	29826880
Device dislocation	20.65	10.36	46	88965	4985	29858482
Cerebral artery thrombosis	20.61	10.36	15	88996	506	29862961
Neuropathy peripheral	20.48	10.36	124	88887	70351	29793116
Dysmetria	20.37	10.36	13	88998	352	29863115
Apathy	20.21	10.36	52	88959	6180	29857287
Arthralgia	20.20	10.36	283	88728	135508	29727959
Hypertonia	20.19	10.36	42	88969	4343	29859124
Depressed mood	20.11	10.36	102	88909	16927	29846540
Hyperammonaemia	19.95	10.36	48	88963	5472	29857995
Multiple sclerosis	19.93	10.36	57	88954	7210	29856257
Persecutory delusion	19.87	10.36	28	88983	2112	29861355
Spasmodic dysphonia	19.81	10.36	8	89003	78	29863389
Coordination abnormal	19.74	10.36	57	88954	7248	29856219
Hepatotoxicity	19.74	10.36	15	88996	18130	29845337
Electrocardiogram QRS complex prolonged	19.73	10.36	41	88970	4236	29859231
Brain scan abnormal	19.70	10.36	16	88995	637	29862830
Multiple sclerosis relapse	19.68	10.36	74	88937	10788	29852679
Heat stroke	19.52	10.36	18	88993	852	29862615
Osteonecrosis of jaw	19.49	10.36	16	88995	18602	29844865
Drug level decreased	19.41	10.36	49	88962	5756	29857711
Bruxism	19.33	10.36	22	88989	1337	29862130
Haematemesis	19.27	10.36	30	88981	26173	29837294
Tubulointerstitial nephritis	19.20	10.36	15	88996	17876	29845591
Reduced facial expression	19.19	10.36	17	88994	763	29862704
Cogwheel rigidity	18.96	10.36	20	88991	1116	29862351
Terminal insomnia	18.85	10.36	13	88998	402	29863065
Hypomania	18.73	10.36	28	88983	2228	29861239
Hypokalaemia	18.73	10.36	81	88930	50111	29813356
Extrapyramidal disorder	18.68	10.36	72	88939	10621	29852846
Blood prolactin increased	18.52	10.36	22	88989	1400	29862067
Partial seizures	18.43	10.36	37	88974	3730	29859737
Exposure via ingestion	18.33	10.36	30	88981	2581	29860886
Poverty of speech	18.28	10.36	10	89001	202	29863265
Aspergillus infection	18.25	10.36	4	89007	10210	29853257
Homicidal ideation	18.25	10.36	29	88982	2434	29861033
Laboratory test abnormal	18.24	10.36	15	88996	17427	29846040
Depersonalisation/derealisation disorder	18.23	10.36	14	88997	513	29862954
Drug intolerance	18.21	10.36	71	88940	45220	29818247
Bacteraemia	18.06	10.36	12	88999	15548	29847919
Major depression	17.91	10.36	38	88973	3984	29859483
Dehydration	17.83	10.36	259	88752	123280	29740187
Victim of crime	17.77	10.36	11	89000	282	29863185
Stereotypy	17.75	10.36	14	88997	534	29862933
Hepatic cirrhosis	17.69	10.36	13	88998	15986	29847481
Haematochezia	17.68	10.36	48	88963	34174	29829293
Developmental regression	17.65	10.36	6	89005	34	29863433
Electrocardiogram QT shortened	17.63	10.36	9	89002	157	29863310
Asthenia	17.58	10.36	512	88499	220778	29642689
Pulmonary embolism	17.58	10.36	148	88863	77987	29785480
Sleep-related eating disorder	17.53	10.36	11	89000	289	29863178
Psoriasis	17.49	10.36	66	88945	42440	29821027
Freezing phenomenon	17.48	10.36	25	88986	1911	29861556
Haemorrhage	17.42	10.36	74	88937	46005	29817462
Nephropathy toxic	17.40	10.36	5	89006	10634	29852833
Frustration tolerance decreased	17.15	10.36	25	88986	1945	29861522
Angina pectoris	17.12	10.36	39	88972	29479	29833988
Renal hypertension	17.08	10.36	9	89002	168	29863299
Obsessive-compulsive personality disorder	17.04	10.36	9	89002	169	29863298
Myelocyte count increased	17.00	10.36	7	89004	72	29863395
Lennox-Gastaut syndrome	16.96	10.36	6	89005	39	29863428
Language disorder	16.90	10.36	20	88991	1268	29862199
Panic reaction	16.89	10.36	21	88990	1402	29862065
Priapism	16.88	10.36	41	88970	4702	29858765
Hyperthermia	16.83	10.36	67	88944	10032	29853435
Physical abuse	16.75	10.36	5	89006	17	29863450
Bipolar I disorder	16.73	10.36	16	88995	793	29862674
Posture abnormal	16.73	10.36	24	88987	1840	29861627
Hypertension	16.63	10.36	257	88754	121097	29742370
Basal cell carcinoma	16.58	10.36	14	88997	16054	29847413
Palmar-plantar erythrodysaesthesia syndrome	16.55	10.36	12	88999	14858	29848609
Muscle spasticity	16.53	10.36	43	88968	5145	29858322
Brain malformation	16.51	10.36	7	89004	78	29863389
Thrombosis	16.47	10.36	67	88944	42164	29821303
Posterior reversible encephalopathy syndrome	16.41	10.36	3	89008	8704	29854763
Sexual dysfunction	16.39	10.36	47	88964	5954	29857513
Encephalitis toxic	16.34	10.36	8	89003	127	29863340
Sedation complication	16.32	10.36	16	88995	818	29862649
Peritonitis	16.17	10.36	24	88987	21351	29842116
Thrombotic microangiopathy	16.16	10.36	3	89008	8607	29854860
Allodynia	15.98	10.36	14	88997	619	29862848
Anaphylactic shock	15.96	10.36	11	89000	13982	29849485
HIV peripheral neuropathy	15.89	10.36	6	89005	48	29863419
Liver disorder	15.87	10.36	41	88970	29681	29833786
Galactorrhoea	15.84	10.36	11	89000	344	29863123
Impulsive behaviour	15.76	10.36	24	88987	1941	29861526
Brain injury	15.68	10.36	44	88967	5504	29857963
Type 2 diabetes mellitus	15.67	10.36	81	88930	13541	29849926
Gout	15.64	10.36	17	88994	17298	29846169
Asterixis	15.62	10.36	19	88992	1240	29862227
Myocarditis	15.56	10.36	65	88946	9946	29853521
Epistaxis	15.51	10.36	93	88918	52888	29810579
Shock haemorrhagic	15.48	10.36	5	89006	9860	29853607
Upper gastrointestinal haemorrhage	15.46	10.36	26	88985	22002	29841465
Muscle contracture	15.43	10.36	18	88993	1124	29862343
Vomiting	15.42	10.36	517	88494	219301	29644166
Stress	15.39	10.36	108	88903	20127	29843340
Increased appetite	15.34	10.36	44	88967	5573	29857894
Deep vein thrombosis	15.29	10.36	111	88900	60390	29803077
Phaeochromocytoma malignant	15.28	10.36	6	89005	54	29863413
Parkinsonian gait	15.18	10.36	12	88999	459	29863008
Arthritis	15.18	10.36	31	88980	24370	29839097
Anhidrosis	15.15	10.36	7	89004	97	29863370
Infantile spasms	15.10	10.36	10	89001	289	29863178
Somnambulism	15.05	10.36	31	88980	3183	29860284
Stoma site erythema	15.02	10.36	17	88994	1027	29862440
Nasal septum deviation	15.00	10.36	16	88995	904	29862563
Chills	14.96	10.36	140	88871	72198	29791269
Hypersomnia	14.96	10.36	70	88941	11246	29852221
Cluster headache	14.95	10.36	13	88998	569	29862898
Feeling guilty	14.95	10.36	10	89001	294	29863173
Blood bicarbonate decreased	14.77	10.36	26	88985	2373	29861094
Logorrhoea	14.72	10.36	24	88987	2058	29861409
Red cell distribution width decreased	14.56	10.36	8	89003	163	29863304
Staphylococcal sepsis	14.56	10.36	5	89006	9486	29853981
Feeling jittery	14.49	10.36	34	88977	3814	29859653
Graft versus host disease	14.48	10.36	6	89005	10144	29853323
Anal spasm	14.47	10.36	3	89008	0	29863467
Eustachian tube disorder	14.47	10.36	3	89008	0	29863467
Stoma site extravasation	14.43	10.36	8	89003	166	29863301
Dependence	14.40	10.36	18	88993	1208	29862259
Mental status changes	14.36	10.36	171	88840	36908	29826559
Libido increased	14.34	10.36	15	88996	829	29862638
Antipsychotic drug level increased	14.20	10.36	30	88981	3136	29860331
Wrong schedule	14.14	10.36	7	89004	114	29863353
Withdrawal hypertension	14.14	10.36	6	89005	67	29863400
Hyperosmolar state	14.10	10.36	11	89000	413	29863054
Postoperative respiratory failure	14.06	10.36	6	89005	68	29863399
Cholangitis	14.05	10.36	3	89008	7799	29855668
Dopamine dysregulation syndrome	13.98	10.36	12	88999	516	29862951
Cytokine release syndrome	13.96	10.36	6	89005	9927	29853540
Tooth injury	13.96	10.36	14	88997	736	29862731
Myalgia	13.94	10.36	153	88858	76514	29786953
Intensive care unit acquired weakness	13.93	10.36	15	88996	857	29862610
Ejaculation disorder	13.91	10.36	16	88995	984	29862483
Locomotive syndrome	13.78	10.36	4	89007	12	29863455
Clonic convulsion	13.73	10.36	12	88999	529	29862938
Cholestasis	13.65	10.36	34	88977	24916	29838551
Self esteem decreased	13.63	10.36	12	88999	534	29862933
Peripheral swelling	13.59	10.36	116	88895	60958	29802509
Accommodation disorder	13.58	10.36	8	89003	187	29863280
Hostility	13.55	10.36	15	88996	884	29862583
Chronic kidney disease	13.55	10.36	62	88949	37776	29825691
Product complaint	13.52	10.36	43	88968	5763	29857704
Drug ineffective for unapproved indication	13.44	10.36	66	88945	10814	29852653
Accidental death	13.41	10.36	23	88988	2056	29861411
Erectile dysfunction	13.41	10.36	96	88915	18006	29845461
Sleep disorder	13.33	10.36	121	88890	24358	29839109
Central pain syndrome	13.32	10.36	7	89004	130	29863337
Death	13.32	10.36	899	88112	356384	29507083
Herpes zoster	13.31	10.36	45	88966	29898	29833569
Haemorrhage intracranial	13.31	10.36	15	88996	15017	29848450
Hyperchloraemia	13.26	10.36	11	89000	451	29863016
Urinary incontinence	13.23	10.36	91	88920	16849	29846618
Gallbladder polyp	13.20	10.36	9	89002	273	29863194
Blepharospasm	13.19	10.36	15	88996	911	29862556
Hypomagnesaemia	13.19	10.36	18	88993	16580	29846887
Lethargy	13.07	10.36	177	88834	39342	29824125
Dementia with Lewy bodies	13.01	10.36	12	88999	568	29862899
Learning disorder	12.98	10.36	11	89000	465	29863002
Inappropriate affect	12.98	10.36	12	88999	570	29862897
Bipolar II disorder	12.90	10.36	4	89007	16	29863451
Psychiatric symptom	12.88	10.36	30	88981	3349	29860118
Tuberculosis	12.84	10.36	4	89007	8073	29855394
Drug level increased	12.83	10.36	96	88915	18258	29845209
Libido decreased	12.70	10.36	36	88975	4530	29858937
Bulbar palsy	12.66	10.36	8	89003	213	29863254
Syncope	12.59	10.36	177	88834	84726	29778741
Purpura	12.53	10.36	7	89004	9960	29853507
Intelligence test abnormal	12.52	10.36	4	89007	18	29863449
Areflexia	12.47	10.36	26	88985	2693	29860774
Dysstasia	12.46	10.36	63	88948	10442	29853025
Accidental poisoning	12.43	10.36	11	89000	493	29862974
Pseudodementia	12.39	10.36	3	89008	3	29863464
Hypothermia neonatal	12.39	10.36	6	89005	93	29863374
Somatic symptom disorder	12.36	10.36	11	89000	497	29862970
Infective pulmonary exacerbation of cystic fibrosis	12.34	10.36	5	89006	8567	29854900
Dementia	12.25	10.36	71	88940	12390	29851077
Hyperhidrosis	12.21	10.36	273	88738	66817	29796650
Substance dependence	12.14	10.36	10	89001	406	29863061
Stupor	12.12	10.36	27	88984	2926	29860541
Autonomic nervous system imbalance	12.11	10.36	24	88987	2397	29861070
Neurosis	12.10	10.36	7	89004	158	29863309
Agitated depression	12.02	10.36	8	89003	233	29863234
Glossopharyngeal nerve disorder	12.02	10.36	4	89007	21	29863446
Squamous cell carcinoma of skin	12	10.36	6	89005	9089	29854378
Neoplasm progression	11.99	10.36	22	88989	18001	29845466
Haematuria traumatic	11.95	10.36	7	89004	162	29863305
Muscle twitching	11.94	10.36	52	88959	8103	29855364
Change in seizure presentation	11.93	10.36	5	89006	54	29863413
Feeling drunk	11.91	10.36	19	88992	1600	29861867
Post concussion syndrome	11.85	10.36	5	89006	55	29863412
Senile dementia	11.85	10.36	5	89006	55	29863412
Atrial flutter	11.84	10.36	15	88996	14266	29849201
Jaundice	11.77	10.36	53	88958	32433	29831034
Cerebral arteriosclerosis	11.69	10.36	10	89001	428	29863039
Mumps	11.68	10.36	6	89005	106	29863361
Clostridium difficile infection	11.67	10.36	18	88993	15765	29847702
Helplessness	11.61	10.36	5	89006	58	29863409
Cytopenia	11.58	10.36	5	89006	8251	29855216
Rapid eye movement sleep behaviour disorder	11.58	10.36	6	89005	108	29863359
Diet refusal	11.58	10.36	9	89002	336	29863131
Social avoidant behaviour	11.55	10.36	26	88985	2837	29860630
Obsessive thoughts	11.53	10.36	12	88999	659	29862808
Pneumothorax	11.47	10.36	19	88992	16174	29847293
Delirium	11.46	10.36	177	88834	40454	29823013
Defect conduction intraventricular	11.39	10.36	7	89004	177	29863290
Prostate cancer	11.35	10.36	35	88976	23922	29839545
Therapy non-responder	11.31	10.36	47	88964	29406	29834061
Dissociative identity disorder	11.30	10.36	4	89007	26	29863441
Tumour lysis syndrome	11.25	10.36	13	88998	12872	29850595
Oropharyngeal pain	11.24	10.36	45	88966	28451	29835016
Communication disorder	11.24	10.36	22	88989	2178	29861289
Chondrocalcinosis	11.23	10.36	8	89003	261	29863206
Ventricular hypoplasia	11.18	10.36	5	89006	64	29863403
Renal injury	11.17	10.36	11	89000	11718	29851749
Pulmonary hypertension	11.16	10.36	25	88986	19011	29844456
Brain oedema	11.14	10.36	69	88942	12329	29851138
Therapeutic response unexpected	10.99	10.36	54	88957	8849	29854618
Pseudomonas infection	10.98	10.36	9	89002	10473	29852994
Adrenal insufficiency	10.94	10.36	9	89002	10454	29853013
Rectal haemorrhage	10.94	10.36	60	88951	34879	29828588
COVID-19	10.88	10.36	23	88988	17855	29845612
Irregular sleep phase	10.84	10.36	5	89006	69	29863398
Blood osmolarity decreased	10.83	10.36	11	89000	587	29862880
Fluid retention	10.82	10.36	38	88973	24960	29838507
Cellulitis	10.80	10.36	88	88923	46696	29816771
Disseminated intravascular coagulation	10.78	10.36	32	88979	22139	29841328
Haemophagocytic lymphohistiocytosis	10.77	10.36	8	89003	9783	29853684
Somatic delusion	10.76	10.36	6	89005	126	29863341
Eye movement disorder	10.76	10.36	31	88980	3937	29859530
Myositis	10.76	10.36	9	89002	10368	29853099
Swelling face	10.76	10.36	30	88981	21174	29842293
Malaise	10.70	10.36	397	88614	166565	29696902
Diffuse large B-cell lymphoma	10.61	10.36	5	89006	7836	29855631
Stoma site inflammation	10.59	10.36	11	89000	603	29862864
Clonus	10.54	10.36	23	88988	2458	29861009
Hallucinations, mixed	10.53	10.36	23	88988	2460	29861007
Acute coronary syndrome	10.50	10.36	15	88996	13558	29849909
Intestinal dilatation	10.47	10.36	15	88996	1149	29862318
Anticonvulsant drug level decreased	10.46	10.36	14	88997	1005	29862462
Peritonitis bacterial	10.46	10.36	11	89000	11367	29852100
Fluid overload	10.45	10.36	26	88985	19066	29844401
Ammonia increased	10.42	10.36	32	88979	4209	29859258
Metamyelocyte count increased	10.41	10.36	5	89006	76	29863391
Face oedema	10.38	10.36	11	89000	11323	29852144

Pharmacologic Action:

Source	Code	Description
ATC	N03AE01	NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Benzodiazepine derivatives
FDA CS	M0002356	Benzodiazepines
FDA EPC	N0000175694	Benzodiazepine
CHEBI has role	CHEBI:35474	minor tranquilisers
CHEBI has role	CHEBI:35623	antiepileptic
CHEBI has role	CHEBI:50268	gaba modulators
MeSH PA	D000927	Anticonvulsants
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D018682	GABA Agents
MeSH PA	D018757	GABA Modulators
MeSH PA	D018377	Neurotransmitter Agents

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Myoclonic seizure	indication	37356005
Atonic seizure	indication	42365007
Absence seizure	indication	79631006
Lennox-Gastaut syndrome	indication	230418006
Panic disorder	indication	371631005	DOID:594
Akathisia	off-label use	285145004
Manic Bipolar Disorder Adjunct Treatment	off-label use
Suicidal thoughts	contraindication	6471006
Alcohol intoxication	contraindication	25702006
Depressive disorder	contraindication	35489007
Hepatic failure	contraindication	59927004
Substance abuse	contraindication	66214007
Sleep apnea	contraindication	73430006	DOID:0050847
Decreased respiratory function	contraindication	80954004
Open-angle glaucoma	contraindication	84494001	DOID:1067
Kidney disease	contraindication	90708001	DOID:557
Liver function tests abnormal	contraindication	166603001
Disease of liver	contraindication	235856003	DOID:409
Syncope	contraindication	271594007
Pregnancy, function	contraindication	289908002
At risk for aspiration	contraindication	371736008
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Breastfeeding (mother)	contraindication	413712001
Chronic lung disease	contraindication	413839001
Central nervous system depression	contraindication	418072004
Porphyria	contraindication	418470004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.65	acidic
pKa2	1.65	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
GABA-A receptor alpha-1/beta-2/gamma-2	Ion channel	P14867 P18507 P47870	GBRA1_HUMAN GBRB2_HUMAN GBRG2_HUMAN	POSITIVE ALLOSTERIC MODULATOR	Ki	8.07	WOMBAT-PK	CHEMBL
GABA-A receptor; anion channel	Ion channel	O00591 O14764 P14867 P18505 P18507 P28472 P31644 P34903 P47869 P47870 P48169 P78334 Q16445 Q8N1C3 Q99928 Q9UN88	GBRA1_HUMAN GBRA2_HUMAN GBRA3_HUMAN GBRA4_HUMAN GBRA5_HUMAN GBRA6_HUMAN GBRB1_HUMAN GBRB2_HUMAN GBRB3_HUMAN GBRD_HUMAN GBRE_HUMAN GBRG1_HUMAN GBRG2_HUMAN GBRG3_HUMAN GBRP_HUMAN GBRT_HUMAN		Ki	9.07	CHEMBL
GABA-A receptor; anion channel	Ion channel		GBRA1_RAT GBRA2_RAT GBRA3_RAT GBRA4_RAT GBRA5_RAT GBRA6_RAT GBRB1_RAT GBRB2_RAT GBRB3_RAT GBRD_RAT GBRE_RAT GBRG1_RAT GBRG2_RAT GBRG3_RAT GBRP_RAT Q91ZM7_RAT		IC50	8.77	CHEMBL
GABA-A receptor; anion channel	Ion channel		GBRA1_BOVIN GBRA2_BOVIN GBRA3_BOVIN GBRA4_BOVIN GBRB1_BOVIN GBRG2_BOVIN		Ki	9.07	CHEMBL

External reference:

ID	Source
4017791	VUID
N0000146152	NUI
D00280	KEGG_DRUG
4017791	VANDF
C0009011	UMLSCUI
CHEBI:3756	CHEBI
CHEMBL452	ChEMBL_ID
DB01068	DRUGBANK_ID
D002998	MESH_DESCRIPTOR_UI
2802	PUBCHEM_CID
6963	IUPHAR_LIGAND_ID
2765	INN_ID
5PE9FDE8GB	UNII
202585	RXNORM
1345	MMSL
377	MMSL
4477	MMSL
d00197	MMSL
001635	NDDF
387383007	SNOMEDCT_US
69708003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Klonopin	HUMAN PRESCRIPTION DRUG LABEL	1	0004-0058	TABLET	1 mg	ORAL	NDA	30 sections
Klonopin	HUMAN PRESCRIPTION DRUG LABEL	1	0004-0068	TABLET	0.50 mg	ORAL	NDA	30 sections
Klonopin	HUMAN PRESCRIPTION DRUG LABEL	1	0004-0098	TABLET	2 mg	ORAL	NDA	30 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0832	TABLET	0.50 mg	ORAL	ANDA	20 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3212	TABLET	1 mg	ORAL	ANDA	20 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3213	TABLET	2 mg	ORAL	ANDA	20 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0063	TABLET	0.50 mg	ORAL	ANDA	24 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0064	TABLET	1 mg	ORAL	ANDA	24 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0065	TABLET	2 mg	ORAL	ANDA	24 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-3003	TABLET	0.50 mg	ORAL	ANDA	24 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-3004	TABLET	1 mg	ORAL	ANDA	24 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-3005	TABLET	2 mg	ORAL	ANDA	24 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0555-0094	TABLET, ORALLY DISINTEGRATING	0.13 mg	ORAL	ANDA	27 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0555-0095	TABLET, ORALLY DISINTEGRATING	0.25 mg	ORAL	ANDA	27 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0555-0096	TABLET, ORALLY DISINTEGRATING	0.50 mg	ORAL	ANDA	27 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0555-0097	TABLET, ORALLY DISINTEGRATING	1 mg	ORAL	ANDA	27 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0555-0098	TABLET, ORALLY DISINTEGRATING	2 mg	ORAL	ANDA	27 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8234	TABLET	0.50 mg	ORAL	ANDA	26 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8235	TABLET	1 mg	ORAL	ANDA	26 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8236	TABLET	2 mg	ORAL	ANDA	26 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0781-5567	TABLET	1 mg	ORAL	ANDA	24 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0781-5569	TABLET	2 mg	ORAL	ANDA	24 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0781-8018	TABLET	0.50 mg	ORAL	ANDA	24 sections
CLONULLZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	16590-058	TABLET	0.50 mg	ORAL	ANDA	23 sections
CLONULLZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	16590-059	TABLET	1 mg	ORAL	ANDA	23 sections
CLONULLZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	16590-481	TABLET	2 mg	ORAL	ANDA	23 sections
KLONOPIN	HUMAN PRESCRIPTION DRUG LABEL	1	16590-693	TABLET	0.50 mg	ORAL	NDA	25 sections
KLONOPIN	HUMAN PRESCRIPTION DRUG LABEL	1	16590-935	TABLET	1 mg	ORAL	NDA	26 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	16714-469	TABLET	0.50 mg	ORAL	ANDA	18 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	16714-470	TABLET	1 mg	ORAL	ANDA	18 sections