clonazepam Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 703 1622-61-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clonazepam
  • lonazep
  • klonopin
An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
  • Molecular weight: 315.71
  • Formula: C15H10ClN3O3
  • CLOGP: 2.38
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 87.28
  • ALOGS: -4.47
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
8 mg O
8 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.42 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 98 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.90 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.88 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.15 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 38 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
June 4, 1975 FDA ROCHE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 8425.24 37.47 1835 4690 19199 2332361
Toxicity to various agents 4405.57 37.47 1200 5325 31554 2320006
Cardio-respiratory arrest 1687.12 37.47 436 6089 8710 2342850
Respiratory arrest 1585.54 37.47 384 6141 5794 2345766
Cardiac arrest 1564.13 37.47 456 6069 14474 2337086
Drug abuse 1007.91 37.47 310 6215 11716 2339844
Overdose 991.89 37.47 346 6179 19561 2331999
Death 894.87 37.47 485 6040 80983 2270577
Intentional overdose 835.51 37.47 265 6260 11056 2340504
Suicide attempt 729.60 37.47 239 6286 11043 2340517
Poisoning 673.62 37.47 166 6359 2654 2348906
Somnolence 578.86 37.47 245 6280 23240 2328320
Drug ineffective 523.60 37.47 375 6150 101249 2250311
Intentional product misuse 474.68 37.47 166 6359 9323 2342237
Seizure 465.73 37.47 213 6312 24253 2327307
Anxiety 443.65 37.47 218 6307 29141 2322419
Hypotension 417.26 37.47 216 6309 32220 2319340
Depressed level of consciousness 360.84 37.47 128 6397 7476 2344084
Unresponsive to stimuli 317.12 37.47 104 6421 4772 2346788
Coma 257.73 37.47 105 6420 8951 2342609
Respiratory depression 250.73 37.47 72 6453 2098 2349462
Drug withdrawal syndrome 239.23 37.47 92 6433 6729 2344831
Insomnia 234.90 37.47 137 6388 25650 2325910
Depression 229.00 37.47 139 6386 27993 2323567
Bradycardia 224.78 37.47 98 6427 9883 2341677
Exposure via ingestion 221.64 37.47 53 6472 735 2350825
Suicidal ideation 221.23 37.47 100 6425 10987 2340573
Tremor 221.09 37.47 122 6403 20539 2331021
Agitation 205.77 37.47 95 6430 10956 2340604
Drug interaction 204.27 37.47 131 6394 29032 2322528
Sedation 203.62 37.47 68 6457 3294 2348266
Drug dependence 202.11 37.47 66 6459 2979 2348581
Electrocardiogram QT prolonged 199.92 37.47 84 6441 7730 2343830
Confusional state 197.29 37.47 120 6405 24224 2327336
Loss of consciousness 195.75 37.47 109 6416 18658 2332902
Neuroleptic malignant syndrome 191.96 37.47 58 6467 2022 2349538
Psychotic disorder 185.30 37.47 69 6456 4610 2346950
Fatigue 182.30 37.47 191 6334 84682 2266878
Lethargy 178.09 37.47 80 6445 8650 2342910
Mental status changes 176.96 37.47 70 6455 5512 2346048
Dizziness 159.00 37.47 150 6375 58515 2293045
Exposure during pregnancy 149.10 37.47 102 6423 25117 2326443
Hypoglycaemia 146.27 37.47 69 6456 8338 2343222
Withdrawal syndrome 146.10 37.47 53 6472 3284 2348276
Hyperhidrosis 145.68 37.47 84 6441 15338 2336222
Disturbance in attention 144.97 37.47 61 6464 5624 2345936
Condition aggravated 138.23 37.47 107 6418 31872 2319688
Feeling abnormal 136.12 37.47 94 6431 23487 2328073
Myocardial depression 132.18 37.47 23 6502 48 2351512
Encephalopathy 130.01 37.47 53 6472 4508 2347052
Hallucination 129.95 37.47 63 6462 8085 2343475
Decorticate posture 127.88 37.47 21 6504 25 2351535
Aggression 124.17 37.47 52 6473 4734 2346826
Serotonin syndrome 121.34 37.47 47 6478 3493 2348067
Sopor 115.83 37.47 47 6478 3948 2347612
Fall 113.44 37.47 113 6412 46986 2304574
Poisoning deliberate 113.26 37.47 34 6491 1157 2350403
Disorientation 112.97 37.47 53 6472 6319 2345241
Balance disorder 110.82 37.47 60 6465 9687 2341873
Medication error 108.71 37.47 51 6474 6080 2345480
Memory impairment 107.84 37.47 65 6460 12858 2338702
Myocardial stunning 107.64 37.47 18 6507 26 2351534
Dysarthria 107.37 37.47 51 6474 6251 2345309
Coma scale abnormal 107.35 37.47 30 6495 788 2350772
Maternal exposure during pregnancy 106.90 37.47 68 6457 14795 2336765
Product complaint 106.75 37.47 46 6479 4492 2347068
Drug hypersensitivity 105.17 37.47 108 6417 46535 2305025
Status epilepticus 103.41 37.47 38 6487 2440 2349120
Nausea 101.60 37.47 165 6360 112024 2239536
Therapeutic response unexpected 100.33 37.47 42 6483 3817 2347743
Malaise 99.60 37.47 114 6411 55471 2296089
Headache 98.36 37.47 136 6389 80043 2271517
Irritability 97.38 37.47 48 6477 6379 2345181
Foetal exposure during pregnancy 97.17 37.47 45 6480 5207 2346353
Weight increased 96.97 37.47 75 6450 22262 2329298
Vomiting 94.69 37.47 126 6399 71476 2280084
Aspiration 88.76 37.47 30 6495 1504 2350056
Schizophrenia 88.28 37.47 29 6496 1330 2350230
Sleep disorder 88.12 37.47 45 6480 6444 2345116
Heart rate increased 87.87 37.47 54 6471 11051 2340509
Panic attack 86.20 37.47 38 6487 3918 2347642
Dystonia 85.51 37.47 32 6493 2162 2349398
Asthenia 85.29 37.47 97 6428 46829 2304731
Tachycardia 84.36 37.47 61 6464 16348 2335212
Muscle rigidity 83.56 37.47 30 6495 1801 2349759
Miosis 83.07 37.47 27 6498 1197 2350363
Ventricular hypokinesia 82.48 37.47 23 6502 599 2350961
Cardiogenic shock 81.56 37.47 32 6493 2459 2349101
Ataxia 81.54 37.47 32 6493 2460 2349100
Restlessness 81.00 37.47 38 6487 4525 2347035
Product substitution issue 80.20 37.47 39 6486 5030 2346530
Myoclonus 78.15 37.47 31 6494 2452 2349108
Electrocardiogram QRS complex prolonged 77.60 37.47 25 6500 1077 2350483
Pulmonary oedema 77.25 37.47 43 6482 7320 2344240
Speech disorder 76.83 37.47 41 6484 6423 2345137
Vision blurred 76.47 37.47 55 6470 14613 2336947
Nervousness 76.35 37.47 38 6487 5151 2346409
Acute respiratory distress syndrome 76.20 37.47 33 6492 3259 2348301
Catatonia 75.38 37.47 23 6502 827 2350733
Hypothermia 75.30 37.47 29 6496 2119 2349441
Pneumonia aspiration 75.30 37.47 34 6491 3708 2347852
Intentional self-injury 75.21 37.47 35 6490 4092 2347468
Mydriasis 70.87 37.47 28 6497 2191 2349369
Cyanosis 70.70 37.47 31 6494 3154 2348406
Urinary bladder rupture 70.15 37.47 13 6512 44 2351516
Abortion spontaneous 69.13 37.47 50 6475 13395 2338165
Respiratory failure 68.86 37.47 50 6475 13478 2338082
Constipation 67.49 37.47 60 6465 21569 2329991
Gait disturbance 67.31 37.47 61 6464 22484 2329076
Amnesia 67.05 37.47 39 6486 7214 2344346
Generalised tonic-clonic seizure 66.45 37.47 35 6490 5337 2346223
Cognitive disorder 66.40 37.47 35 6490 5346 2346214
Blood pressure decreased 65.72 37.47 42 6483 9194 2342366
Syncope 65.33 37.47 53 6472 16822 2334738
Accidental overdose 64.15 37.47 31 6494 3941 2347619
Aphasia 63.50 37.47 33 6492 4895 2346665
Electrocardiogram QRS complex shortened 62.99 37.47 13 6512 86 2351474
Rhabdomyolysis 61.84 37.47 36 6489 6668 2344892
Paranoia 61.78 37.47 25 6500 2082 2349478
Mania 61.55 37.47 26 6499 2414 2349146
Drug screen positive 61.23 37.47 20 6505 900 2350660
Purpura senile 59.57 37.47 10 6515 15 2351545
Delirium 58.90 37.47 32 6493 5191 2346369
Pregnancy 58.67 37.47 37 6488 7912 2343648
Drug screen negative 58.32 37.47 12 6513 78 2351482
Dysphagia 57.71 37.47 44 6481 12761 2338799
Respiratory rate decreased 57.22 37.47 17 6508 557 2351003
Incontinence 55.90 37.47 21 6504 1433 2350127
Hepatitis 55.74 37.47 33 6492 6304 2345256
Mental disorder 55.00 37.47 28 6497 3979 2347581
Arrhythmia 54.62 37.47 32 6493 5996 2345564
Treatment noncompliance 54.46 37.47 31 6494 5503 2346057
Alanine aminotransferase increased 54.15 37.47 44 6481 13988 2337572
Developmental glaucoma 52.66 37.47 9 6516 16 2351544
Delusion 52.07 37.47 22 6503 2043 2349517
Intellectual disability 51.98 37.47 12 6513 141 2351419
Anger 51.13 37.47 23 6502 2484 2349076
Hypoxia 51.07 37.47 31 6494 6196 2345364
Pneumonia 50.60 37.47 77 6448 49219 2302341
Body temperature decreased 50.47 37.47 19 6506 1304 2350256
Weight decreased 50.36 37.47 58 6467 28313 2323247
Hypersomnia 49.19 37.47 22 6503 2344 2349216
Hypotonia 48.91 37.47 20 6505 1710 2349850
Palpitations 48.06 37.47 44 6481 16412 2335148
Off label use 47.99 37.47 94 6431 73504 2278056
Tarsal tunnel syndrome 47.79 37.47 9 6516 34 2351526
Dyskinesia 47.59 37.47 27 6498 4762 2346798
Soft tissue haemorrhage 47.58 37.47 9 6516 35 2351525
Pupil fixed 47.56 37.47 14 6511 444 2351116
Product use in unapproved indication 47.22 37.47 37 6488 11163 2340397
Dehydration 47.20 37.47 50 6475 22245 2329315
Paradoxical drug reaction 47.11 37.47 14 6511 459 2351101
Fear 47.08 37.47 22 6503 2594 2348966
Muscle spasms 46.79 37.47 49 6476 21517 2330043
Hepatic necrosis 46.22 37.47 17 6508 1093 2350467
Akathisia 46.13 37.47 19 6506 1655 2349905
Blood creatine phosphokinase increased 45.83 37.47 27 6498 5109 2346451
Urinary retention 45.65 37.47 24 6501 3643 2347917
Nightmare 45.47 37.47 24 6501 3673 2347887
Aspartate aminotransferase increased 45.42 37.47 38 6487 12574 2338986
Multiple organ dysfunction syndrome 45.26 37.47 31 6494 7610 2343950
Substance abuse 45.06 37.47 14 6511 535 2351025
Blood pressure increased 44.96 37.47 43 6482 16943 2334617
Blood sodium decreased 43.53 37.47 22 6503 3078 2348482
Electroencephalogram abnormal 43.26 37.47 15 6510 812 2350748
Drug withdrawal syndrome neonatal 43.24 37.47 13 6512 444 2351116
Coordination abnormal 42.98 37.47 19 6506 1969 2349591
Decreased appetite 42.97 37.47 54 6471 28837 2322723
Hyperreflexia 42.00 37.47 15 6510 886 2350674
Emotional disorder 41.33 37.47 19 6506 2158 2349402
No adverse event 41.30 37.47 32 6493 9496 2342064
Parkinsonism 41.19 37.47 17 6508 1488 2350072
Drug resistance 40.92 37.47 20 6505 2604 2348956
Paraesthesia 40.61 37.47 46 6479 22042 2329518
Hypoaesthesia 40.43 37.47 44 6481 20171 2331389
Antipsychotic drug level increased 40.43 37.47 13 6512 556 2351004
Toxic leukoencephalopathy 40.04 37.47 9 6516 93 2351467
Loss of personal independence in daily activities 39.88 37.47 25 6500 5286 2346274
Therapeutic product effect decreased 39.87 37.47 33 6492 10756 2340804
Hypomania 39.76 37.47 14 6511 793 2350767
Metabolic acidosis 39.52 37.47 26 6499 5972 2345588
Dyspnoea 39.08 37.47 90 6435 78643 2272917
Crying 38.93 37.47 23 6502 4373 2347187
Skin abrasion 38.75 37.47 15 6510 1110 2350450
Hypophagia 38.26 37.47 22 6503 3978 2347582
Epileptic encephalopathy 38.16 37.47 7 6518 22 2351538
Incoherent 38.04 37.47 14 6511 901 2350659
Pyrexia 37.92 37.47 71 6454 53637 2297923
Depressed mood 37.86 37.47 24 6501 5174 2346386
Alcohol poisoning 37.85 37.47 11 6514 333 2351227
Epilepsy 37.79 37.47 23 6502 4616 2346944
Panic disorder 37.67 37.47 12 6513 498 2351062
Drug withdrawal convulsions 37.54 37.47 11 6514 343 2351217

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3128.06 43.16 812 3651 15500 1726818
Toxicity to various agents 2832.84 43.16 851 3612 28290 1714028
Drug abuse 1905.20 43.16 533 3930 13156 1729162
Respiratory arrest 1055.13 43.16 281 4182 5558 1736760
Cardio-respiratory arrest 1021.75 43.16 303 4160 8990 1733328
Cardiac arrest 931.07 43.16 321 4142 15609 1726709
Overdose 646.98 43.16 249 4214 16452 1725866
Death 551.41 43.16 381 4082 87062 1655256
Intentional product misuse 469.20 43.16 159 4304 7199 1735119
Drug ineffective 390.13 43.16 274 4189 63527 1678791
Poisoning 349.33 43.16 99 4364 2433 1739885
Intentional overdose 322.99 43.16 122 4341 7548 1734770
Seizure 315.12 43.16 160 4303 20281 1722037
Suicide attempt 309.30 43.16 117 4346 7264 1735054
Coma 303.87 43.16 115 4348 7147 1735171
Sedation 303.20 43.16 95 4368 3322 1738996
Somnolence 293.26 43.16 143 4320 16596 1725722
Drug interaction 291.98 43.16 169 4294 27789 1714529
Anxiety 266.93 43.16 131 4332 15396 1726922
Respiratory depression 248.36 43.16 74 4389 2173 1740145
Depressed level of consciousness 242.12 43.16 95 4368 6497 1735821
Unresponsive to stimuli 225.34 43.16 82 4381 4547 1737771
Agitation 198.14 43.16 96 4367 10930 1731388
Depression 190.20 43.16 107 4356 16562 1725756
Aggression 177.62 43.16 81 4382 8034 1734284
Hypotension 169.54 43.16 123 4340 29531 1712787
Confusional state 161.09 43.16 105 4358 21173 1721145
Neuroleptic malignant syndrome 157.71 43.16 57 4406 3091 1739227
Substance abuse 155.38 43.16 43 4420 960 1741358
Serotonin syndrome 152.94 43.16 54 4409 2734 1739584
Insomnia 149.93 43.16 91 4372 16185 1726133
Ataxia 142.23 43.16 49 4414 2304 1740014
Loss of consciousness 136.54 43.16 83 4380 14792 1727526
Status epilepticus 133.01 43.16 45 4418 2001 1740317
Fall 126.82 43.16 100 4363 27114 1715204
Abnormal behaviour 122.20 43.16 58 4405 6284 1736034
Accidental overdose 111.73 43.16 48 4415 4116 1738202
Drug dependence 108.24 43.16 44 4419 3283 1739035
Encephalopathy 105.42 43.16 47 4416 4405 1737913
Parkinsonism 104.51 43.16 34 4429 1335 1740983
Speech disorder 104.46 43.16 47 4416 4501 1737817
Muscle rigidity 102.10 43.16 36 4427 1812 1740506
Tachycardia 99.50 43.16 64 4399 12564 1729754
Pulmonary oedema 99.36 43.16 51 4412 6535 1735783
Drug withdrawal syndrome 98.35 43.16 45 4418 4480 1737838
Dysarthria 94.91 43.16 46 4417 5213 1737105
Condition aggravated 94.72 43.16 76 4387 21074 1721244
Gait disturbance 94.39 43.16 62 4401 12608 1729710
Medication error 93.24 43.16 44 4419 4699 1737619
Disinhibition 93.20 43.16 23 4440 321 1741997
Mental status changes 91.51 43.16 47 4416 6028 1736290
Exposure via ingestion 90.96 43.16 26 4437 654 1741664
Electrocardiogram QT prolonged 89.64 43.16 45 4418 5500 1736818
Intentional self-injury 89.16 43.16 36 4427 2637 1739681
Brain oedema 88.80 43.16 34 4429 2162 1740156
Acute pulmonary oedema 87.95 43.16 29 4434 1188 1741130
Tremor 87.59 43.16 60 4403 13071 1729247
Disturbance in attention 85.44 43.16 40 4423 4194 1738124
Bradycardia 84.47 43.16 54 4409 10480 1731838
Suicidal ideation 81.83 43.16 49 4414 8469 1733849
Generalised tonic-clonic seizure 80.95 43.16 38 4425 4008 1738310
Hyperhidrosis 80.78 43.16 56 4407 12432 1729886
Epilepsy 78.64 43.16 37 4426 3922 1738396
Dystonia 77.21 43.16 30 4433 1984 1740334
Acute respiratory distress syndrome 76.16 43.16 35 4428 3516 1738802
Dyskinesia 73.73 43.16 35 4428 3784 1738534
Poisoning deliberate 68.69 43.16 22 4441 820 1741498
Asterixis 67.80 43.16 17 4446 254 1742064
Salivary hypersecretion 67.64 43.16 25 4438 1440 1740878
Myoclonus 66.65 43.16 28 4435 2267 1740051
Psychotic disorder 64.44 43.16 35 4428 5021 1737297
Respiratory failure 60.38 43.16 50 4413 14455 1727863
Blood creatine phosphokinase increased 60.27 43.16 41 4422 8815 1733503
Miosis 60.16 43.16 23 4440 1455 1740863
Drug screen positive 59.93 43.16 21 4442 1036 1741282
Hyponatraemia 59.67 43.16 41 4422 8959 1733359
Off label use 59.56 43.16 78 4385 38493 1703825
Dysmetria 59.36 43.16 12 4451 61 1742257
Personality disorder 58.86 43.16 15 4448 240 1742078
Hypotonia 58.81 43.16 23 4440 1547 1740771
Illness anxiety disorder 58.53 43.16 11 4452 35 1742283
Treatment noncompliance 58.06 43.16 33 4430 5168 1737150
Foetal exposure during pregnancy 56.97 43.16 35 4428 6324 1735994
Withdrawal syndrome 56.85 43.16 25 4438 2263 1740055
Multiple-drug resistance 55.96 43.16 15 4448 295 1742023
Catatonia 55.66 43.16 19 4444 866 1741452
Thinking abnormal 55.50 43.16 21 4442 1291 1741027
Memory impairment 55.47 43.16 35 4428 6628 1735690
Drug level increased 55.28 43.16 26 4437 2751 1739567
Electrocardiogram QRS complex prolonged 54.11 43.16 18 4445 757 1741561
Postictal paralysis 53.40 43.16 10 4453 31 1742287
Restlessness 52.53 43.16 29 4434 4292 1738026
Panic attack 51.79 43.16 22 4441 1830 1740488
Sleep apnoea syndrome 51.78 43.16 23 4440 2131 1740187
Sinus tachycardia 51.30 43.16 24 4439 2508 1739810
Rhabdomyolysis 49.86 43.16 40 4423 11050 1731268
Intentional product use issue 49.67 43.16 24 4439 2695 1739623
Delirium 49.43 43.16 32 4431 6330 1735988
Mental disorder 48.65 43.16 24 4439 2819 1739499
Lethargy 48.25 43.16 33 4430 7151 1735167
Product substitution issue 48.22 43.16 25 4438 3261 1739057
Respiratory acidosis 48.12 43.16 16 4447 672 1741646
Fatigue 47.21 43.16 81 4382 50700 1691618
Pneumonia aspiration 47.20 43.16 29 4434 5237 1737081
Cognitive disorder 47.05 43.16 27 4436 4303 1738015
Hyperthermia 46.99 43.16 20 4443 1671 1740647
Disorientation 46.19 43.16 29 4434 5440 1736878
Drooling 46.01 43.16 16 4447 771 1741547
Product complaint 45.55 43.16 22 4441 2468 1739850
Feeling of despair 45.30 43.16 12 4451 225 1742093
Apathy 45.08 43.16 18 4445 1278 1741040
Depression suicidal 44.90 43.16 12 4451 233 1742085
Altered state of consciousness 43.97 43.16 24 4439 3473 1738845

Pharmacologic Action:

SourceCodeDescription
ATC N03AE01 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Benzodiazepine derivatives
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:50268 GABA modulator
CHEBI has role CHEBI:35474 anxiolytic drug
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D018377 Neurotransmitter Agents
FDA EPC N0000175694 Benzodiazepine
FDA CS M0002356 Benzodiazepines

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Myoclonic seizure indication 37356005
Atonic seizure indication 42365007
Absence seizure indication 79631006
Lennox-Gastaut syndrome indication 230418006
Panic disorder indication 371631005 DOID:594
Akathisia off-label use 285145004
Manic Bipolar Disorder Adjunct Treatment off-label use
Suicidal thoughts contraindication 6471006
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Hepatic failure contraindication 59927004
Substance abuse contraindication 66214007
Sleep apnea contraindication 73430006 DOID:0050847
Decreased respiratory function contraindication 80954004
Open-angle glaucoma contraindication 84494001 DOID:1067
Kidney disease contraindication 90708001 DOID:557
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Syncope contraindication 271594007
Pregnancy, function contraindication 289908002
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.65 acidic
pKa2 1.65 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 8.07 WOMBAT-PK CHEMBL
GABA-A receptor; anion channel Ion channel Ki 9.07 CHEMBL
GABA-A receptor; anion channel Ion channel IC50 8.77 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 9.07 CHEMBL

External reference:

IDSource
D002998 MESH_DESCRIPTOR_UI
4017791 VUID
N0000146152 NUI
C0009011 UMLSCUI
D00280 KEGG_DRUG
5PE9FDE8GB UNII
2765 INN_ID
69708003 SNOMEDCT_US
4017791 VANDF
001635 NDDF
2598 RXNORM
377 MMSL
d00197 MMSL
387383007 SNOMEDCT_US
4477 MMSL
CHEMBL452 ChEMBL_ID
DB01068 DRUGBANK_ID
CHEBI:3756 CHEBI
6963 IUPHAR_LIGAND_ID
2802 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Klonopin HUMAN PRESCRIPTION DRUG LABEL 1 0004-0058 TABLET 1 mg ORAL NDA 15 sections
Klonopin HUMAN PRESCRIPTION DRUG LABEL 1 0004-0068 TABLET 0.50 mg ORAL NDA 15 sections
Klonopin HUMAN PRESCRIPTION DRUG LABEL 1 0004-0098 TABLET 2 mg ORAL NDA 15 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-0832 TABLET 0.50 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3212 TABLET 1 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3213 TABLET 2 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0185-0063 TABLET 0.50 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0185-0064 TABLET 1 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0185-0065 TABLET 2 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-3003 TABLET 0.50 mg ORAL ANDA 15 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-3004 TABLET 1 mg ORAL ANDA 15 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-3005 TABLET 2 mg ORAL ANDA 15 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-1910 TABLET 0.50 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-1912 TABLET 1 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-1914 TABLET 2 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0094 TABLET, ORALLY DISINTEGRATING 0.13 mg ORAL ANDA 15 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0095 TABLET, ORALLY DISINTEGRATING 0.25 mg ORAL ANDA 15 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0096 TABLET, ORALLY DISINTEGRATING 0.50 mg ORAL ANDA 15 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0097 TABLET, ORALLY DISINTEGRATING 1 mg ORAL ANDA 15 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0098 TABLET, ORALLY DISINTEGRATING 2 mg ORAL ANDA 15 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-7796 TABLET 0.50 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8001 TABLET 0.50 mg ORAL ANDA 13 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8002 TABLET 1 mg ORAL ANDA 13 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8048 TABLET 2 mg ORAL ANDA 13 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8227 TABLET 0.50 mg ORAL ANDA 15 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8234 TABLET 0.50 mg ORAL ANDA 13 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8235 TABLET 1 mg ORAL ANDA 13 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8236 TABLET 2 mg ORAL ANDA 13 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0781-5567 TABLET 1 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0781-5569 TABLET 2 mg ORAL ANDA 14 sections