Stem definition | Drug id | CAS RN |
---|---|---|
diazepam derivatives | 703 | 1622-61-3 |
Dose | Unit | Route |
---|---|---|
8 | mg | O |
8 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.10 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.42 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 98 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 2.90 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.88 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.15 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 38 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
June 4, 1975 | FDA | ROCHE |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1871.71 | 9.73 | 2446 | 163998 | 143474 | 46376144 |
Toxicity to various agents | 702.21 | 9.73 | 1994 | 164450 | 209772 | 46309846 |
Suicide attempt | 475.83 | 9.73 | 767 | 165677 | 54269 | 46465349 |
Drug abuse | 448.28 | 9.73 | 808 | 165636 | 62600 | 46457018 |
Anxiety | 389.03 | 9.73 | 1477 | 164967 | 180480 | 46339138 |
Respiratory arrest | 372.89 | 9.73 | 528 | 165916 | 33288 | 46486330 |
Suicidal ideation | 363.97 | 9.73 | 691 | 165753 | 55691 | 46463927 |
Intentional overdose | 352.13 | 9.73 | 740 | 165704 | 64204 | 46455414 |
Rheumatoid arthritis | 351.08 | 9.73 | 211 | 166233 | 240004 | 46279614 |
Depression | 318.56 | 9.73 | 1325 | 165119 | 168779 | 46350839 |
Seizure | 303.56 | 9.73 | 1047 | 165397 | 122007 | 46397611 |
Cardio-respiratory arrest | 301.36 | 9.73 | 662 | 165782 | 59207 | 46460411 |
Sopor | 279.19 | 9.73 | 349 | 166095 | 19479 | 46500139 |
Overdose | 272.97 | 9.73 | 892 | 165552 | 101087 | 46418531 |
Somnolence | 236.32 | 9.73 | 1144 | 165300 | 155377 | 46364241 |
Drug withdrawal syndrome | 231.57 | 9.73 | 378 | 166066 | 27006 | 46492612 |
Cardiac arrest | 201.25 | 9.73 | 744 | 165700 | 89655 | 46429963 |
Irritability | 195.71 | 9.73 | 362 | 166082 | 28584 | 46491034 |
Contraindicated product administered | 194.59 | 9.73 | 27 | 166417 | 79920 | 46439698 |
Psychotic disorder | 192.27 | 9.73 | 313 | 166131 | 22308 | 46497310 |
Acute kidney injury | 187.47 | 9.73 | 347 | 166097 | 235508 | 46284110 |
Insomnia | 185.40 | 9.73 | 1112 | 165332 | 163812 | 46355806 |
Intentional self-injury | 175.80 | 9.73 | 312 | 166132 | 23854 | 46495764 |
Synovitis | 168.23 | 9.73 | 13 | 166431 | 61062 | 46458556 |
Tremor | 167.11 | 9.73 | 835 | 165609 | 114804 | 46404814 |
Drug dependence | 153.95 | 9.73 | 264 | 166180 | 19637 | 46499981 |
Drug hypersensitivity | 149.55 | 9.73 | 413 | 166031 | 243412 | 46276206 |
Panic attack | 149.38 | 9.73 | 263 | 166181 | 19979 | 46499639 |
Febrile neutropenia | 139.57 | 9.73 | 82 | 166362 | 94545 | 46425073 |
Poisoning | 138.93 | 9.73 | 208 | 166236 | 13786 | 46505832 |
Anaemia | 135.68 | 9.73 | 463 | 165981 | 255316 | 46264302 |
Schizophrenia | 130.60 | 9.73 | 157 | 166287 | 8411 | 46511207 |
Agitation | 129.95 | 9.73 | 464 | 165980 | 54951 | 46464667 |
Stubbornness | 127.54 | 9.73 | 43 | 166401 | 190 | 46519428 |
Hypomania | 126.11 | 9.73 | 113 | 166331 | 4275 | 46515343 |
Withdrawal syndrome | 124.09 | 9.73 | 228 | 166216 | 17906 | 46501712 |
Treatment failure | 120.73 | 9.73 | 93 | 166351 | 92994 | 46426624 |
Drug intolerance | 117.01 | 9.73 | 216 | 166228 | 146833 | 46372785 |
Anger | 114.58 | 9.73 | 174 | 166270 | 11678 | 46507940 |
Intentional product misuse | 111.68 | 9.73 | 396 | 166048 | 46732 | 46472886 |
Sedation | 110.31 | 9.73 | 249 | 166195 | 22661 | 46496957 |
Abnormal behaviour | 107.17 | 9.73 | 234 | 166210 | 20824 | 46498794 |
Neutropenia | 105.59 | 9.73 | 220 | 166224 | 142984 | 46376634 |
Diarrhoea | 104.97 | 9.73 | 1387 | 165057 | 558215 | 45961403 |
Mental disorder | 101.65 | 9.73 | 238 | 166206 | 22187 | 46497431 |
Unresponsive to stimuli | 101.31 | 9.73 | 298 | 166146 | 31876 | 46487742 |
Aggression | 99.43 | 9.73 | 238 | 166206 | 22506 | 46497112 |
Thrombocytopenia | 98.00 | 9.73 | 189 | 166255 | 126392 | 46393226 |
Mania | 97.53 | 9.73 | 154 | 166290 | 10692 | 46508926 |
Neuroleptic malignant syndrome | 97.37 | 9.73 | 156 | 166288 | 10966 | 46508652 |
Crying | 96.52 | 9.73 | 225 | 166219 | 20916 | 46498702 |
Systemic lupus erythematosus | 93.97 | 9.73 | 58 | 166386 | 65122 | 46454496 |
Sepsis | 92.84 | 9.73 | 218 | 166226 | 135796 | 46383822 |
Atrial fibrillation | 92.71 | 9.73 | 141 | 166303 | 103449 | 46416169 |
Rash | 92.70 | 9.73 | 819 | 165625 | 355693 | 46163925 |
Disturbance in attention | 92.48 | 9.73 | 285 | 166159 | 31275 | 46488343 |
Restless legs syndrome | 91.02 | 9.73 | 185 | 166259 | 15658 | 46503960 |
Thinking abnormal | 90.54 | 9.73 | 141 | 166303 | 9673 | 46509945 |
Paranoia | 89.18 | 9.73 | 146 | 166298 | 10451 | 46509167 |
Amnesia | 87.88 | 9.73 | 337 | 166107 | 41294 | 46478324 |
Memory impairment | 87.09 | 9.73 | 522 | 165922 | 76815 | 46442803 |
Depressed level of consciousness | 86.80 | 9.73 | 368 | 166076 | 47201 | 46472417 |
Infusion related reaction | 85.61 | 9.73 | 143 | 166301 | 101065 | 46418553 |
Joint swelling | 85.01 | 9.73 | 305 | 166139 | 165768 | 46353850 |
Feeling abnormal | 84.63 | 9.73 | 747 | 165697 | 124313 | 46395305 |
Ataxia | 84.02 | 9.73 | 166 | 166278 | 13764 | 46505854 |
Weight increased | 83.83 | 9.73 | 926 | 165518 | 163547 | 46356071 |
Cardiac failure | 83.58 | 9.73 | 97 | 166347 | 79851 | 46439767 |
Mood altered | 82.10 | 9.73 | 158 | 166286 | 12849 | 46506769 |
Speech disorder | 81.51 | 9.73 | 299 | 166145 | 35868 | 46483750 |
Dyspnoea | 79.85 | 9.73 | 1326 | 165118 | 514222 | 46005396 |
Drug withdrawal convulsions | 79.29 | 9.73 | 53 | 166391 | 1288 | 46518330 |
Dyskinesia | 79.06 | 9.73 | 255 | 166189 | 28670 | 46490948 |
Tardive dyskinesia | 79.02 | 9.73 | 115 | 166329 | 7428 | 46512190 |
Dystonia | 78.87 | 9.73 | 143 | 166301 | 11114 | 46508504 |
Nervousness | 75.99 | 9.73 | 249 | 166195 | 28226 | 46491392 |
Interstitial lung disease | 72.38 | 9.73 | 52 | 166392 | 53897 | 46465721 |
Hallucination | 72.28 | 9.73 | 361 | 166083 | 49590 | 46470028 |
Hyperhidrosis | 71.40 | 9.73 | 554 | 165890 | 88754 | 46430864 |
Pancytopenia | 71.18 | 9.73 | 121 | 166323 | 84937 | 46434681 |
Infection | 69.25 | 9.73 | 244 | 166200 | 133348 | 46386270 |
Malignant neoplasm progression | 68.70 | 9.73 | 78 | 166366 | 64848 | 46454770 |
Gastrointestinal haemorrhage | 67.60 | 9.73 | 107 | 166337 | 77266 | 46442352 |
Pleural effusion | 67.59 | 9.73 | 120 | 166324 | 82832 | 46436786 |
Disease progression | 67.48 | 9.73 | 140 | 166304 | 91160 | 46428458 |
Hand deformity | 66.92 | 9.73 | 20 | 166424 | 34554 | 46485064 |
Epilepsy | 66.44 | 9.73 | 211 | 166233 | 23527 | 46496091 |
Multiple sclerosis relapse | 66.38 | 9.73 | 312 | 166132 | 41813 | 46477805 |
Hypersomnia | 64.74 | 9.73 | 159 | 166285 | 15280 | 46504338 |
Balance disorder | 64.21 | 9.73 | 422 | 166022 | 64099 | 46455519 |
Bradyphrenia | 63.84 | 9.73 | 94 | 166350 | 6136 | 46513482 |
Akathisia | 63.19 | 9.73 | 105 | 166339 | 7609 | 46512009 |
Plasma cell myeloma | 62.16 | 9.73 | 41 | 166403 | 44437 | 46475181 |
Arthralgia | 61.97 | 9.73 | 921 | 165523 | 363682 | 46155936 |
Nightmare | 61.37 | 9.73 | 163 | 166281 | 16435 | 46503183 |
Product substitution issue | 61.13 | 9.73 | 153 | 166291 | 14878 | 46504740 |
Renal impairment | 61.13 | 9.73 | 107 | 166337 | 74265 | 46445353 |
General physical health deterioration | 60.96 | 9.73 | 210 | 166234 | 115559 | 46404059 |
Serotonin syndrome | 60.38 | 9.73 | 207 | 166237 | 24013 | 46495605 |
Mucosal inflammation | 58.55 | 9.73 | 33 | 166411 | 38943 | 46480675 |
Lactic acidosis | 58.12 | 9.73 | 24 | 166420 | 33885 | 46485733 |
Bipolar disorder | 57.87 | 9.73 | 97 | 166347 | 7080 | 46512538 |
Cardiac failure congestive | 56.43 | 9.73 | 155 | 166289 | 91595 | 46428023 |
Drooling | 54.23 | 9.73 | 62 | 166382 | 3147 | 46516471 |
Maternal exposure during pregnancy | 53.33 | 9.73 | 187 | 166257 | 102362 | 46417256 |
Glossodynia | 52.99 | 9.73 | 48 | 166396 | 44325 | 46475293 |
Bone marrow failure | 52.49 | 9.73 | 20 | 166424 | 29649 | 46489969 |
Hallucination, auditory | 51.88 | 9.73 | 117 | 166327 | 10639 | 46508979 |
Respiratory depression | 51.36 | 9.73 | 122 | 166322 | 11478 | 46508140 |
Arthropathy | 50.67 | 9.73 | 145 | 166299 | 84555 | 46435063 |
Myocardial stunning | 49.98 | 9.73 | 20 | 166424 | 155 | 46519463 |
Status epilepticus | 49.39 | 9.73 | 135 | 166309 | 13844 | 46505774 |
Drug screen negative | 49.05 | 9.73 | 25 | 166419 | 358 | 46519260 |
Hypersensitivity | 48.50 | 9.73 | 325 | 166119 | 149996 | 46369622 |
Haemoglobin decreased | 48.30 | 9.73 | 266 | 166178 | 128683 | 46390935 |
Mood swings | 47.82 | 9.73 | 147 | 166297 | 16105 | 46503513 |
Muscle rigidity | 47.65 | 9.73 | 108 | 166336 | 9853 | 46509765 |
Granulocytopenia | 46.21 | 9.73 | 74 | 166370 | 5199 | 46514419 |
Peripheral swelling | 46.03 | 9.73 | 352 | 166092 | 157719 | 46361899 |
Dysarthria | 46.02 | 9.73 | 259 | 166185 | 37239 | 46482379 |
Mydriasis | 45.65 | 9.73 | 110 | 166334 | 10443 | 46509175 |
Feeling of despair | 45.11 | 9.73 | 43 | 166401 | 1762 | 46517856 |
Swelling | 44.93 | 9.73 | 260 | 166184 | 124251 | 46395367 |
Off label use | 44.89 | 9.73 | 1022 | 165422 | 378819 | 46140799 |
Alopecia | 44.82 | 9.73 | 367 | 166077 | 162047 | 46357571 |
Multiple sclerosis | 44.60 | 9.73 | 191 | 166253 | 24600 | 46495018 |
Herpes zoster | 43.75 | 9.73 | 112 | 166332 | 67760 | 46451858 |
Blood creatinine increased | 43.39 | 9.73 | 134 | 166310 | 76269 | 46443349 |
Platelet count decreased | 43.37 | 9.73 | 196 | 166248 | 99828 | 46419790 |
Restlessness | 43.14 | 9.73 | 193 | 166251 | 25331 | 46494287 |
Stomatitis | 43.03 | 9.73 | 114 | 166330 | 68183 | 46451435 |
Vision blurred | 42.50 | 9.73 | 453 | 165991 | 79255 | 46440363 |
Exposure via ingestion | 42.49 | 9.73 | 57 | 166387 | 3410 | 46516208 |
Renal failure | 42.17 | 9.73 | 235 | 166209 | 113359 | 46406259 |
Therapeutic response unexpected | 42.06 | 9.73 | 137 | 166307 | 15479 | 46504139 |
Lower respiratory tract infection | 41.95 | 9.73 | 83 | 166361 | 55006 | 46464612 |
Palmar-plantar erythrodysaesthesia syndrome | 41.12 | 9.73 | 11 | 166433 | 20440 | 46499178 |
Melaena | 41.02 | 9.73 | 24 | 166420 | 27748 | 46491870 |
Bradykinesia | 40.87 | 9.73 | 60 | 166384 | 3906 | 46515712 |
Lethargy | 40.64 | 9.73 | 317 | 166127 | 50854 | 46468764 |
Delusion | 40.48 | 9.73 | 109 | 166335 | 11079 | 46508539 |
Myocardial depression | 39.83 | 9.73 | 24 | 166420 | 484 | 46519134 |
Dysphoria | 39.66 | 9.73 | 64 | 166380 | 4525 | 46515093 |
Personality disorder | 39.15 | 9.73 | 52 | 166392 | 3081 | 46516537 |
Osteonecrosis of jaw | 38.99 | 9.73 | 39 | 166405 | 34363 | 46485255 |
Decorticate posture | 38.98 | 9.73 | 21 | 166423 | 339 | 46519279 |
Loss of consciousness | 38.73 | 9.73 | 571 | 165873 | 107667 | 46411951 |
Angioedema | 38.71 | 9.73 | 50 | 166394 | 39292 | 46480326 |
Confusional state | 38.64 | 9.73 | 792 | 165652 | 159100 | 46360518 |
Sluggishness | 38.62 | 9.73 | 64 | 166380 | 4627 | 46514991 |
Substance abuse | 38.62 | 9.73 | 60 | 166384 | 4107 | 46515511 |
Gastric pH decreased | 38.33 | 9.73 | 21 | 166423 | 351 | 46519267 |
Hyperkalaemia | 38.10 | 9.73 | 77 | 166367 | 50632 | 46468986 |
Parkinsonism | 37.82 | 9.73 | 86 | 166358 | 7862 | 46511756 |
Hyponatraemia | 36.33 | 9.73 | 212 | 166232 | 101120 | 46418498 |
Pericarditis | 36.31 | 9.73 | 20 | 166424 | 23907 | 46495711 |
Head injury | 36.30 | 9.73 | 179 | 166265 | 24457 | 46495161 |
Depressed mood | 36.27 | 9.73 | 223 | 166221 | 33096 | 46486522 |
Panic disorder | 35.91 | 9.73 | 45 | 166399 | 2516 | 46517102 |
Breast hyperplasia | 35.49 | 9.73 | 18 | 166426 | 255 | 46519363 |
Atonic seizures | 35.45 | 9.73 | 24 | 166420 | 596 | 46519022 |
Impaired driving ability | 35.28 | 9.73 | 58 | 166386 | 4166 | 46515452 |
Pneumocystis jirovecii pneumonia | 35.15 | 9.73 | 6 | 166438 | 15242 | 46504376 |
Psychomotor hyperactivity | 35.13 | 9.73 | 94 | 166350 | 9519 | 46510099 |
Drug interaction | 35.00 | 9.73 | 960 | 165484 | 202134 | 46317484 |
Abdominal discomfort | 35.00 | 9.73 | 357 | 166087 | 150808 | 46368810 |
Major depression | 34.78 | 9.73 | 75 | 166369 | 6615 | 46513003 |
Pulmonary arterial hypertension | 34.76 | 9.73 | 25 | 166419 | 25903 | 46493715 |
Dissociation | 34.69 | 9.73 | 38 | 166406 | 1839 | 46517779 |
Myocardial infarction | 34.46 | 9.73 | 205 | 166239 | 97323 | 46422295 |
Jaundice cholestatic | 34.11 | 9.73 | 63 | 166381 | 4966 | 46514652 |
Leukopenia | 33.95 | 9.73 | 127 | 166317 | 68216 | 46451402 |
Neutrophil count decreased | 33.43 | 9.73 | 65 | 166379 | 43361 | 46476257 |
Gait disturbance | 33.29 | 9.73 | 714 | 165730 | 144549 | 46375069 |
Catatonia | 33.25 | 9.73 | 53 | 166391 | 3709 | 46515909 |
Coma | 33.17 | 9.73 | 336 | 166108 | 58013 | 46461605 |
Abnormal dreams | 33.11 | 9.73 | 96 | 166348 | 10183 | 46509435 |
Emotional disorder | 33.08 | 9.73 | 108 | 166336 | 12216 | 46507402 |
Hypercalcaemia | 32.80 | 9.73 | 17 | 166427 | 21029 | 46498589 |
Cogwheel rigidity | 32.59 | 9.73 | 33 | 166411 | 1457 | 46518161 |
Stress | 32.32 | 9.73 | 303 | 166141 | 51248 | 46468370 |
Adjustment disorder with mixed anxiety and depressed mood | 32.31 | 9.73 | 12 | 166432 | 74 | 46519544 |
Septic shock | 31.84 | 9.73 | 103 | 166341 | 57790 | 46461828 |
Coma blister | 31.80 | 9.73 | 14 | 166430 | 141 | 46519477 |
Electrocardiogram QT prolonged | 30.85 | 9.73 | 299 | 166145 | 51026 | 46468592 |
Cytomegalovirus infection | 30.84 | 9.73 | 13 | 166431 | 18131 | 46501487 |
Mental status changes | 30.82 | 9.73 | 237 | 166207 | 37851 | 46481767 |
Road traffic accident | 30.65 | 9.73 | 166 | 166278 | 23525 | 46496093 |
Anaphylactic reaction | 30.26 | 9.73 | 93 | 166351 | 53019 | 46466599 |
Cognitive disorder | 30.12 | 9.73 | 230 | 166214 | 36653 | 46482965 |
Autonomic nervous system imbalance | 29.91 | 9.73 | 40 | 166404 | 2386 | 46517232 |
Product complaint | 29.79 | 9.73 | 103 | 166341 | 11998 | 46507620 |
Disorientation | 29.47 | 9.73 | 229 | 166215 | 36689 | 46482929 |
Vomiting | 29.09 | 9.73 | 1319 | 165125 | 451475 | 46068143 |
Galactorrhoea | 28.87 | 9.73 | 50 | 166394 | 3747 | 46515871 |
Bruxism | 28.74 | 9.73 | 44 | 166400 | 2973 | 46516645 |
Hypocalcaemia | 28.52 | 9.73 | 32 | 166412 | 26753 | 46492865 |
Developmental glaucoma | 28.19 | 9.73 | 10 | 166434 | 53 | 46519565 |
Drug screen positive | 27.98 | 9.73 | 50 | 166394 | 3841 | 46515777 |
Drug use disorder | 27.64 | 9.73 | 41 | 166403 | 2694 | 46516924 |
Incoherent | 27.49 | 9.73 | 54 | 166390 | 4458 | 46515160 |
Skin ulcer | 27.30 | 9.73 | 46 | 166398 | 32412 | 46487206 |
Device expulsion | 27.10 | 9.73 | 35 | 166409 | 27507 | 46492111 |
Hyperprolactinaemia | 26.87 | 9.73 | 42 | 166402 | 2890 | 46516728 |
Dopamine dysregulation syndrome | 26.85 | 9.73 | 15 | 166429 | 261 | 46519357 |
Obsessive-compulsive disorder | 26.65 | 9.73 | 44 | 166400 | 3171 | 46516447 |
Right ventricular failure | 26.60 | 9.73 | 12 | 166432 | 16081 | 46503537 |
Migraine | 26.46 | 9.73 | 373 | 166071 | 69653 | 46449965 |
Urinary bladder rupture | 26.41 | 9.73 | 12 | 166432 | 131 | 46519487 |
Nystagmus | 26.38 | 9.73 | 61 | 166383 | 5638 | 46513980 |
Muscle twitching | 26.36 | 9.73 | 113 | 166331 | 14559 | 46505059 |
Pneumonia | 26.27 | 9.73 | 1086 | 165358 | 375234 | 46144384 |
Muscle spasms | 25.94 | 9.73 | 598 | 165846 | 122515 | 46397103 |
Affect lability | 25.92 | 9.73 | 75 | 166369 | 7945 | 46511673 |
C-reactive protein increased | 25.88 | 9.73 | 114 | 166330 | 58476 | 46461142 |
Pleurothotonus | 25.84 | 9.73 | 26 | 166418 | 1139 | 46518479 |
Derealisation | 25.73 | 9.73 | 22 | 166422 | 781 | 46518837 |
Fear | 25.63 | 9.73 | 120 | 166324 | 16052 | 46503566 |
Anticonvulsant drug level above therapeutic | 25.44 | 9.73 | 18 | 166426 | 481 | 46519137 |
Electroencephalogram abnormal | 25.42 | 9.73 | 47 | 166397 | 3707 | 46515911 |
Persecutory delusion | 25.39 | 9.73 | 38 | 166406 | 2517 | 46517101 |
Upper gastrointestinal haemorrhage | 25.38 | 9.73 | 14 | 166430 | 16724 | 46502894 |
Multiple-drug resistance | 25.28 | 9.73 | 38 | 166406 | 2527 | 46517091 |
Fall | 25.06 | 9.73 | 1423 | 165021 | 327674 | 46191944 |
Sleep disorder | 24.95 | 9.73 | 266 | 166178 | 46529 | 46473089 |
Oromandibular dystonia | 24.87 | 9.73 | 17 | 166427 | 429 | 46519189 |
On and off phenomenon | 24.81 | 9.73 | 33 | 166411 | 1958 | 46517660 |
Extrapyramidal disorder | 24.41 | 9.73 | 92 | 166352 | 11176 | 46508442 |
Hyperbilirubinaemia | 24.30 | 9.73 | 4 | 166440 | 10434 | 46509184 |
Acute myeloid leukaemia | 24.21 | 9.73 | 13 | 166431 | 15765 | 46503853 |
Neoplasm progression | 24.16 | 9.73 | 36 | 166408 | 26647 | 46492971 |
Jaundice | 24.15 | 9.73 | 41 | 166403 | 28804 | 46490814 |
Erythema | 24.09 | 9.73 | 361 | 166083 | 142459 | 46377159 |
Transplant rejection | 23.91 | 9.73 | 3 | 166441 | 9593 | 46510025 |
Urticaria | 23.87 | 9.73 | 287 | 166157 | 117605 | 46402013 |
Ascites | 23.86 | 9.73 | 60 | 166384 | 36524 | 46483094 |
Dizziness | 23.84 | 9.73 | 1461 | 164983 | 338953 | 46180665 |
Proteinuria | 23.47 | 9.73 | 15 | 166429 | 16538 | 46503080 |
Mutism | 23.47 | 9.73 | 26 | 166418 | 1274 | 46518344 |
Middle insomnia | 23.43 | 9.73 | 81 | 166363 | 9434 | 46510184 |
Nasopharyngitis | 23.39 | 9.73 | 397 | 166047 | 153601 | 46366017 |
Fluid overload | 23.35 | 9.73 | 38 | 166406 | 27147 | 46492471 |
Head titubation | 23.27 | 9.73 | 19 | 166425 | 632 | 46518986 |
Generalised tonic-clonic seizure | 23.20 | 9.73 | 171 | 166273 | 26951 | 46492667 |
Movement disorder | 23.12 | 9.73 | 120 | 166324 | 16729 | 46502889 |
Apathy | 22.57 | 9.73 | 67 | 166377 | 7201 | 46512417 |
Psychomotor retardation | 22.56 | 9.73 | 41 | 166403 | 3192 | 46516426 |
Anorgasmia | 22.53 | 9.73 | 18 | 166426 | 580 | 46519038 |
Rubber sensitivity | 22.52 | 9.73 | 29 | 166415 | 1667 | 46517951 |
Formication | 22.49 | 9.73 | 46 | 166398 | 3910 | 46515708 |
Aspiration | 22.49 | 9.73 | 80 | 166364 | 9451 | 46510167 |
Metastases to liver | 22.42 | 9.73 | 22 | 166422 | 19563 | 46500055 |
Hereditary angioedema | 22.27 | 9.73 | 56 | 166388 | 5460 | 46514158 |
Band neutrophil percentage increased | 22.04 | 9.73 | 12 | 166432 | 198 | 46519420 |
Pneumonia aspiration | 21.45 | 9.73 | 189 | 166255 | 31416 | 46488202 |
Pulmonary fibrosis | 21.40 | 9.73 | 24 | 166420 | 20068 | 46499550 |
Miosis | 21.27 | 9.73 | 62 | 166382 | 6595 | 46513023 |
Pyrexia | 21.17 | 9.73 | 1022 | 165422 | 347780 | 46171838 |
Seizure cluster | 21.07 | 9.73 | 11 | 166433 | 166 | 46519452 |
Dependence | 21.04 | 9.73 | 30 | 166414 | 1901 | 46517717 |
Coordination abnormal | 20.97 | 9.73 | 86 | 166358 | 10863 | 46508755 |
Conversion disorder | 20.94 | 9.73 | 28 | 166416 | 1670 | 46517948 |
Incontinence | 20.94 | 9.73 | 80 | 166364 | 9782 | 46509836 |
Hostility | 20.83 | 9.73 | 25 | 166419 | 1337 | 46518281 |
Hypokalaemia | 20.72 | 9.73 | 207 | 166237 | 87817 | 46431801 |
Peritonitis | 20.71 | 9.73 | 26 | 166418 | 20688 | 46498930 |
Pneumonitis | 20.63 | 9.73 | 44 | 166400 | 28376 | 46491242 |
Helicobacter infection | 20.61 | 9.73 | 8 | 166436 | 11728 | 46507890 |
Tension | 20.59 | 9.73 | 37 | 166407 | 2855 | 46516763 |
Pulmonary hypertension | 20.52 | 9.73 | 63 | 166381 | 35930 | 46483688 |
Hypertension | 20.48 | 9.73 | 538 | 165906 | 195818 | 46323800 |
Weight abnormal | 20.43 | 9.73 | 21 | 166423 | 944 | 46518674 |
Knee arthroplasty | 20.40 | 9.73 | 33 | 166411 | 23632 | 46495986 |
Tachyphrenia | 20.19 | 9.73 | 24 | 166420 | 1270 | 46518348 |
Broncholithiasis | 20.16 | 9.73 | 9 | 166435 | 94 | 46519524 |
Neuropathy peripheral | 20.07 | 9.73 | 217 | 166227 | 90676 | 46428942 |
Panic reaction | 19.92 | 9.73 | 42 | 166402 | 3647 | 46515971 |
Urinary retention | 19.89 | 9.73 | 160 | 166284 | 25901 | 46493717 |
Epistaxis | 19.74 | 9.73 | 141 | 166303 | 64164 | 46455454 |
Anaphylactic shock | 19.70 | 9.73 | 26 | 166418 | 20248 | 46499370 |
Wound | 19.68 | 9.73 | 82 | 166362 | 42720 | 46476898 |
Rash pruritic | 19.54 | 9.73 | 86 | 166358 | 44129 | 46475489 |
Exposure during pregnancy | 19.48 | 9.73 | 270 | 166174 | 107942 | 46411676 |
Diverticulitis | 19.43 | 9.73 | 57 | 166387 | 32982 | 46486636 |
Cerebellar atrophy | 19.40 | 9.73 | 17 | 166427 | 624 | 46518994 |
Prescribed overdose | 19.17 | 9.73 | 81 | 166363 | 10368 | 46509250 |
Nausea | 19.16 | 9.73 | 2153 | 164291 | 685301 | 45834317 |
White blood cell count decreased | 19.15 | 9.73 | 283 | 166161 | 111948 | 46407670 |
Neutropenic sepsis | 19.14 | 9.73 | 10 | 166434 | 12314 | 46507304 |
Bone erosion | 19.13 | 9.73 | 5 | 166439 | 9438 | 46510180 |
Hypomagnesaemia | 19.12 | 9.73 | 31 | 166413 | 22179 | 46497439 |
Fibromyalgia | 18.85 | 9.73 | 206 | 166238 | 36257 | 46483361 |
Drug ineffective | 18.74 | 9.73 | 2124 | 164320 | 675714 | 45843904 |
Hypokinesia | 18.67 | 9.73 | 85 | 166359 | 11237 | 46508381 |
Liver function test increased | 18.60 | 9.73 | 33 | 166411 | 22793 | 46496825 |
Cough | 18.56 | 9.73 | 653 | 165791 | 229596 | 46290022 |
Libido increased | 18.56 | 9.73 | 18 | 166426 | 754 | 46518864 |
Myelocyte percentage increased | 18.53 | 9.73 | 10 | 166434 | 162 | 46519456 |
Stereotypy | 18.53 | 9.73 | 14 | 166430 | 415 | 46519203 |
Food craving | 18.50 | 9.73 | 22 | 166422 | 1165 | 46518453 |
Intellectual disability | 18.49 | 9.73 | 17 | 166427 | 665 | 46518953 |
International normalised ratio increased | 18.49 | 9.73 | 95 | 166349 | 46788 | 46472830 |
Aphasia | 18.45 | 9.73 | 169 | 166275 | 28398 | 46491220 |
Liver function test abnormal | 18.44 | 9.73 | 94 | 166350 | 46393 | 46473225 |
Therapeutic product effect decreased | 18.32 | 9.73 | 197 | 166247 | 82404 | 46437214 |
Bipolar I disorder | 18.31 | 9.73 | 25 | 166419 | 1521 | 46518097 |
Suicidal behaviour | 18.31 | 9.73 | 32 | 166412 | 2416 | 46517202 |
Anticonvulsant drug level below therapeutic | 18.24 | 9.73 | 16 | 166428 | 588 | 46519030 |
Antidepressant drug level above therapeutic | 18.22 | 9.73 | 13 | 166431 | 352 | 46519266 |
Full blood count decreased | 18.20 | 9.73 | 32 | 166412 | 22179 | 46497439 |
Acute myocardial infarction | 18.11 | 9.73 | 56 | 166388 | 31868 | 46487750 |
Antipsychotic drug level increased | 18.01 | 9.73 | 37 | 166407 | 3155 | 46516463 |
Abdominal pain | 17.94 | 9.73 | 655 | 165789 | 229376 | 46290242 |
Depersonalisation/derealisation disorder | 17.89 | 9.73 | 20 | 166424 | 990 | 46518628 |
Circulatory collapse | 17.86 | 9.73 | 31 | 166413 | 21593 | 46498025 |
Disseminated intravascular coagulation | 17.84 | 9.73 | 25 | 166419 | 18980 | 46500638 |
Dysstasia | 17.83 | 9.73 | 116 | 166328 | 17552 | 46502066 |
Osteonecrosis | 17.75 | 9.73 | 41 | 166403 | 25703 | 46493915 |
Musculoskeletal pain | 17.74 | 9.73 | 162 | 166282 | 69966 | 46449652 |
Drug abuser | 17.68 | 9.73 | 37 | 166407 | 3196 | 46516422 |
Weight gain poor | 17.55 | 9.73 | 17 | 166427 | 711 | 46518907 |
Colitis | 17.52 | 9.73 | 71 | 166373 | 37276 | 46482342 |
Impulsive behaviour | 17.20 | 9.73 | 24 | 166420 | 1491 | 46518127 |
Tongue discolouration | 17.16 | 9.73 | 35 | 166409 | 2969 | 46516649 |
Libido decreased | 16.88 | 9.73 | 32 | 166412 | 2573 | 46517045 |
Hypothermia | 16.88 | 9.73 | 87 | 166357 | 12096 | 46507522 |
Screaming | 16.85 | 9.73 | 36 | 166408 | 3155 | 46516463 |
Haematuria | 16.78 | 9.73 | 45 | 166399 | 26813 | 46492805 |
Stoma site discharge | 16.69 | 9.73 | 27 | 166417 | 1913 | 46517705 |
Change in seizure presentation | 16.69 | 9.73 | 11 | 166433 | 261 | 46519357 |
Shock haemorrhagic | 16.67 | 9.73 | 5 | 166439 | 8619 | 46510999 |
Cerebral haemorrhage | 16.64 | 9.73 | 49 | 166395 | 28322 | 46491296 |
Drug tolerance | 16.64 | 9.73 | 36 | 166408 | 3182 | 46516436 |
Hepatocellular injury | 16.59 | 9.73 | 52 | 166392 | 29470 | 46490148 |
Coronary artery disease | 16.57 | 9.73 | 63 | 166381 | 33689 | 46485929 |
Dysgraphia | 16.51 | 9.73 | 33 | 166411 | 2759 | 46516859 |
Peripheral pulse decreased | 16.44 | 9.73 | 6 | 166438 | 35 | 46519583 |
Mitral valve thickening | 16.29 | 9.73 | 6 | 166438 | 36 | 46519582 |
Tic | 16.20 | 9.73 | 21 | 166423 | 1215 | 46518403 |
H1N1 influenza | 16.09 | 9.73 | 23 | 166421 | 1461 | 46518157 |
Urinary incontinence | 16.07 | 9.73 | 164 | 166280 | 28366 | 46491252 |
Injection site pruritus | 15.97 | 9.73 | 80 | 166364 | 39663 | 46479955 |
Cytopenia | 15.96 | 9.73 | 4 | 166440 | 7764 | 46511854 |
Polycystic ovaries | 15.82 | 9.73 | 22 | 166422 | 1362 | 46518256 |
Thrombotic microangiopathy | 15.72 | 9.73 | 5 | 166439 | 8301 | 46511317 |
Myoclonus | 15.58 | 9.73 | 96 | 166348 | 14256 | 46505362 |
Blood triglycerides increased | 15.53 | 9.73 | 83 | 166361 | 11700 | 46507918 |
Electrocardiogram QRS complex shortened | 15.48 | 9.73 | 12 | 166432 | 370 | 46519248 |
Psychiatric symptom | 15.46 | 9.73 | 43 | 166401 | 4454 | 46515164 |
Lymph node calcification | 15.41 | 9.73 | 9 | 166435 | 171 | 46519447 |
Oliguria | 15.33 | 9.73 | 6 | 166438 | 8753 | 46510865 |
Haematemesis | 15.32 | 9.73 | 52 | 166392 | 28754 | 46490864 |
Social anxiety disorder | 15.28 | 9.73 | 12 | 166432 | 377 | 46519241 |
Dysphagia | 15.20 | 9.73 | 372 | 166072 | 76940 | 46442678 |
Cerebrovascular accident | 15.16 | 9.73 | 261 | 166183 | 100778 | 46418840 |
Metabolic acidosis | 15.05 | 9.73 | 79 | 166365 | 38701 | 46480917 |
Schizoaffective disorder | 15.01 | 9.73 | 22 | 166422 | 1430 | 46518188 |
Disorganised speech | 15.01 | 9.73 | 17 | 166427 | 854 | 46518764 |
Hip arthroplasty | 14.93 | 9.73 | 26 | 166418 | 18086 | 46501532 |
Drug ineffective for unapproved indication | 14.91 | 9.73 | 105 | 166339 | 16308 | 46503310 |
Pupil fixed | 14.88 | 9.73 | 24 | 166420 | 1696 | 46517922 |
Oedema | 14.85 | 9.73 | 160 | 166284 | 66911 | 46452707 |
Emotional distress | 14.75 | 9.73 | 171 | 166273 | 30536 | 46489082 |
Initial insomnia | 14.75 | 9.73 | 42 | 166402 | 4410 | 46515208 |
Impaired healing | 14.74 | 9.73 | 74 | 166370 | 36669 | 46482949 |
Cholestasis | 14.68 | 9.73 | 48 | 166396 | 26845 | 46492773 |
Blood growth hormone increased | 14.67 | 9.73 | 12 | 166432 | 400 | 46519218 |
Dehydration | 14.62 | 9.73 | 445 | 165999 | 159095 | 46360523 |
Motor dysfunction | 14.59 | 9.73 | 58 | 166386 | 7224 | 46512394 |
Femur fracture | 14.57 | 9.73 | 75 | 166369 | 36922 | 46482696 |
Menstrual disorder | 14.47 | 9.73 | 40 | 166404 | 4128 | 46515490 |
Attention deficit hyperactivity disorder | 14.47 | 9.73 | 27 | 166417 | 2145 | 46517473 |
Sensitisation | 14.45 | 9.73 | 15 | 166429 | 682 | 46518936 |
Hyperkeratosis | 14.36 | 9.73 | 45 | 166399 | 4980 | 46514638 |
Rash maculo-papular | 14.36 | 9.73 | 51 | 166393 | 27823 | 46491795 |
Intervertebral disc protrusion | 14.35 | 9.73 | 123 | 166321 | 20282 | 46499336 |
Right ventricular systolic pressure decreased | 14.33 | 9.73 | 5 | 166439 | 25 | 46519593 |
Flight of ideas | 14.25 | 9.73 | 11 | 166433 | 337 | 46519281 |
Fluid retention | 14.22 | 9.73 | 115 | 166329 | 50931 | 46468687 |
Ketosis-prone diabetes mellitus | 14.20 | 9.73 | 4 | 166440 | 8 | 46519610 |
Diplopia | 14.19 | 9.73 | 118 | 166326 | 19287 | 46500331 |
Congenital knee deformity | 14.17 | 9.73 | 5 | 166439 | 26 | 46519592 |
Influenza like illness | 14.16 | 9.73 | 286 | 166158 | 57284 | 46462334 |
Abulia | 14.11 | 9.73 | 11 | 166433 | 342 | 46519276 |
Logorrhoea | 14.09 | 9.73 | 28 | 166416 | 2331 | 46517287 |
Bradycardia neonatal | 14.05 | 9.73 | 14 | 166430 | 606 | 46519012 |
Feeling of body temperature change | 13.97 | 9.73 | 40 | 166404 | 4212 | 46515406 |
Bacteraemia | 13.97 | 9.73 | 18 | 166426 | 14161 | 46505457 |
Tonic clonic movements | 13.96 | 9.73 | 19 | 166425 | 1153 | 46518465 |
Oculocephalogyric reflex absent | 13.92 | 9.73 | 3 | 166441 | 0 | 46519618 |
Periorbital swelling | 13.90 | 9.73 | 20 | 166424 | 1278 | 46518340 |
Multiple organ dysfunction syndrome | 13.72 | 9.73 | 118 | 166326 | 51592 | 46468026 |
Pericardial effusion | 13.66 | 9.73 | 46 | 166398 | 25497 | 46494121 |
Blepharospasm | 13.59 | 9.73 | 27 | 166417 | 2247 | 46517371 |
Blood prolactin increased | 13.58 | 9.73 | 32 | 166412 | 2995 | 46516623 |
Coma scale abnormal | 13.55 | 9.73 | 44 | 166400 | 4962 | 46514656 |
Metastases to lung | 13.46 | 9.73 | 11 | 166433 | 10685 | 46508933 |
Clumsiness | 13.38 | 9.73 | 23 | 166421 | 1713 | 46517905 |
Self-injurious ideation | 13.38 | 9.73 | 27 | 166417 | 2273 | 46517345 |
Tubulointerstitial nephritis | 13.34 | 9.73 | 20 | 166424 | 14768 | 46504850 |
Nephrogenic diabetes insipidus | 13.33 | 9.73 | 15 | 166429 | 748 | 46518870 |
Periodic limb movement disorder | 13.29 | 9.73 | 8 | 166436 | 161 | 46519457 |
COVID-19 | 13.28 | 9.73 | 29 | 166415 | 18546 | 46501072 |
Heart rate abnormal | 13.27 | 9.73 | 34 | 166410 | 3353 | 46516265 |
Post-traumatic stress disorder | 13.22 | 9.73 | 38 | 166406 | 4010 | 46515608 |
Oculogyric crisis | 13.21 | 9.73 | 19 | 166425 | 1214 | 46518404 |
Hyperreflexia | 13.17 | 9.73 | 45 | 166399 | 5209 | 46514409 |
Pruritus | 13.17 | 9.73 | 718 | 165726 | 241634 | 46277984 |
Upper respiratory tract infection | 13.13 | 9.73 | 154 | 166290 | 63402 | 46456216 |
Haematochezia | 13.13 | 9.73 | 79 | 166365 | 37414 | 46482204 |
Inflammation | 13.08 | 9.73 | 111 | 166333 | 48670 | 46470948 |
Haemoglobin urine | 12.99 | 9.73 | 7 | 166437 | 113 | 46519505 |
Injection site erythema | 12.93 | 9.73 | 187 | 166257 | 74240 | 46445378 |
Sebaceous gland infection | 12.88 | 9.73 | 7 | 166437 | 115 | 46519503 |
Distractibility | 12.88 | 9.73 | 10 | 166434 | 309 | 46519309 |
Suspected product quality issue | 12.87 | 9.73 | 8 | 166436 | 171 | 46519447 |
Compulsive shopping | 12.83 | 9.73 | 15 | 166429 | 780 | 46518838 |
Tinnitus | 12.80 | 9.73 | 153 | 166291 | 27520 | 46492098 |
Ejection fraction | 12.75 | 9.73 | 13 | 166431 | 579 | 46519039 |
Decreased interest | 12.73 | 9.73 | 32 | 166412 | 3120 | 46516498 |
Tearfulness | 12.73 | 9.73 | 38 | 166406 | 4097 | 46515521 |
Acute generalised exanthematous pustulosis | 12.70 | 9.73 | 9 | 166435 | 9396 | 46510222 |
Prescribed underdose | 12.70 | 9.73 | 80 | 166364 | 11973 | 46507645 |
Pathogen resistance | 12.68 | 9.73 | 3 | 166441 | 6057 | 46513561 |
Hepatic enzyme increased | 12.68 | 9.73 | 210 | 166234 | 81577 | 46438041 |
Therapeutic product effect incomplete | 12.67 | 9.73 | 199 | 166245 | 77954 | 46441664 |
Parkinsonian gait | 12.65 | 9.73 | 12 | 166432 | 489 | 46519129 |
Myoclonic epilepsy | 12.60 | 9.73 | 16 | 166428 | 907 | 46518711 |
Victim of crime | 12.56 | 9.73 | 6 | 166438 | 74 | 46519544 |
Parasomnia | 12.55 | 9.73 | 11 | 166433 | 404 | 46519214 |
Peroneal nerve palsy | 12.54 | 9.73 | 38 | 166406 | 4130 | 46515488 |
Anticonvulsant drug level increased | 12.54 | 9.73 | 20 | 166424 | 1400 | 46518218 |
Flat affect | 12.46 | 9.73 | 19 | 166425 | 1279 | 46518339 |
Gaze palsy | 12.46 | 9.73 | 19 | 166425 | 1279 | 46518339 |
Drop attacks | 12.46 | 9.73 | 14 | 166430 | 697 | 46518921 |
Choking | 12.44 | 9.73 | 61 | 166383 | 8315 | 46511303 |
Heart rate increased | 12.42 | 9.73 | 352 | 166092 | 74439 | 46445179 |
Cellulitis | 12.42 | 9.73 | 176 | 166268 | 70112 | 46449506 |
Colitis ulcerative | 12.42 | 9.73 | 28 | 166416 | 17704 | 46501914 |
Hyperammonaemic encephalopathy | 12.41 | 9.73 | 24 | 166420 | 1958 | 46517660 |
Barotrauma | 12.39 | 9.73 | 8 | 166436 | 183 | 46519435 |
Sensorimotor disorder | 12.39 | 9.73 | 11 | 166433 | 411 | 46519207 |
Congenital jaw malformation | 12.38 | 9.73 | 4 | 166440 | 15 | 46519603 |
Narcotic bowel syndrome | 12.37 | 9.73 | 7 | 166437 | 125 | 46519493 |
Hyperammonaemia | 12.36 | 9.73 | 41 | 166403 | 4675 | 46514943 |
Cerebral atrophy | 12.36 | 9.73 | 41 | 166403 | 4675 | 46514943 |
Abscess | 12.32 | 9.73 | 19 | 166425 | 13870 | 46505748 |
Band neutrophil count increased | 12.26 | 9.73 | 10 | 166434 | 332 | 46519286 |
Sleep-related eating disorder | 12.26 | 9.73 | 13 | 166431 | 606 | 46519012 |
Enuresis | 12.26 | 9.73 | 24 | 166420 | 1976 | 46517642 |
Staphylococcal infection | 12.20 | 9.73 | 76 | 166368 | 35695 | 46483923 |
Pulmonary haemorrhage | 12.16 | 9.73 | 4 | 166440 | 6501 | 46513117 |
Stoma site pain | 12.10 | 9.73 | 17 | 166427 | 1063 | 46518555 |
Colitis ischaemic | 12.05 | 9.73 | 11 | 166433 | 10121 | 46509497 |
Ischaemic stroke | 12.04 | 9.73 | 26 | 166418 | 16696 | 46502922 |
Urine oxalate increased | 11.98 | 9.73 | 8 | 166436 | 194 | 46519424 |
Euphoric mood | 11.98 | 9.73 | 38 | 166406 | 4234 | 46515384 |
Freezing phenomenon | 11.96 | 9.73 | 20 | 166424 | 1457 | 46518161 |
Cholelithiasis | 11.90 | 9.73 | 199 | 166245 | 38482 | 46481136 |
Specific gravity urine decreased | 11.89 | 9.73 | 11 | 166433 | 434 | 46519184 |
Increased appetite | 11.89 | 9.73 | 61 | 166383 | 8466 | 46511152 |
Salivary hypersecretion | 11.86 | 9.73 | 50 | 166394 | 6395 | 46513223 |
Aerophagia | 11.85 | 9.73 | 3 | 166441 | 3 | 46519615 |
Large intestine operation | 11.85 | 9.73 | 3 | 166441 | 3 | 46519615 |
Drug detoxification | 11.84 | 9.73 | 8 | 166436 | 198 | 46519420 |
Transfusion | 11.83 | 9.73 | 18 | 166426 | 13213 | 46506405 |
Bronchopulmonary aspergillosis | 11.76 | 9.73 | 6 | 166438 | 7490 | 46512128 |
Dysphemia | 11.76 | 9.73 | 26 | 166418 | 2332 | 46517286 |
Suspected suicide | 11.76 | 9.73 | 40 | 166404 | 4621 | 46514997 |
Drug screen false positive | 11.65 | 9.73 | 15 | 166429 | 862 | 46518756 |
Klebsiella test positive | 11.63 | 9.73 | 16 | 166428 | 981 | 46518637 |
Clostridium difficile infection | 11.60 | 9.73 | 48 | 166396 | 25055 | 46494563 |
Adrenal insufficiency | 11.60 | 9.73 | 18 | 166426 | 13106 | 46506512 |
Post-traumatic neck syndrome | 11.58 | 9.73 | 19 | 166425 | 1362 | 46518256 |
Essential tremor | 11.57 | 9.73 | 14 | 166430 | 755 | 46518863 |
Feeling jittery | 11.55 | 9.73 | 73 | 166371 | 10935 | 46508683 |
Coagulopathy | 11.55 | 9.73 | 31 | 166413 | 18468 | 46501150 |
Monocyte count abnormal | 11.53 | 9.73 | 8 | 166436 | 207 | 46519411 |
Homicidal ideation | 11.51 | 9.73 | 22 | 166422 | 1780 | 46517838 |
Arthritis | 11.50 | 9.73 | 200 | 166244 | 77116 | 46442502 |
Trismus | 11.49 | 9.73 | 33 | 166411 | 3482 | 46516136 |
Dairy intolerance | 11.48 | 9.73 | 5 | 166439 | 49 | 46519569 |
Fractured coccyx | 11.46 | 9.73 | 16 | 166428 | 994 | 46518624 |
Soft tissue haemorrhage | 11.40 | 9.73 | 8 | 166436 | 211 | 46519407 |
Acute hepatic failure | 11.36 | 9.73 | 22 | 166422 | 14699 | 46504919 |
Sleep terror | 11.35 | 9.73 | 14 | 166430 | 770 | 46518848 |
Binge eating | 11.35 | 9.73 | 10 | 166434 | 370 | 46519248 |
Feeling drunk | 11.29 | 9.73 | 35 | 166409 | 3852 | 46515766 |
Lupus-like syndrome | 11.27 | 9.73 | 7 | 166437 | 7837 | 46511781 |
Feelings of worthlessness | 11.24 | 9.73 | 9 | 166435 | 291 | 46519327 |
Eating disorder | 11.20 | 9.73 | 90 | 166354 | 14564 | 46505054 |
Cast application | 11.15 | 9.73 | 4 | 166440 | 22 | 46519596 |
Metastases to bone | 11.13 | 9.73 | 29 | 166415 | 17447 | 46502171 |
Concussion | 11.12 | 9.73 | 52 | 166392 | 6951 | 46512667 |
Family stress | 11.12 | 9.73 | 12 | 166432 | 571 | 46519047 |
Laryngeal stenosis | 11.10 | 9.73 | 13 | 166431 | 677 | 46518941 |
Coagulation factor VII level decreased | 11.00 | 9.73 | 4 | 166440 | 23 | 46519595 |
Hyperacusis | 10.98 | 9.73 | 22 | 166422 | 1842 | 46517776 |
Gastrointestinal disorder | 10.95 | 9.73 | 148 | 166296 | 59428 | 46460190 |
Stoma site hypergranulation | 10.89 | 9.73 | 11 | 166433 | 484 | 46519134 |
Impulse-control disorder | 10.89 | 9.73 | 13 | 166431 | 691 | 46518927 |
Sleep apnoea syndrome | 10.82 | 9.73 | 124 | 166320 | 22077 | 46497541 |
Injection site pain | 10.79 | 9.73 | 295 | 166149 | 106857 | 46412761 |
Anuria | 10.76 | 9.73 | 15 | 166429 | 11416 | 46508202 |
Altered state of consciousness | 10.76 | 9.73 | 129 | 166315 | 23219 | 46496399 |
Haemorrhage intracranial | 10.73 | 9.73 | 18 | 166426 | 12706 | 46506912 |
Haematoma | 10.72 | 9.73 | 68 | 166376 | 31804 | 46487814 |
Foetal growth restriction | 10.69 | 9.73 | 5 | 166439 | 6562 | 46513056 |
Psychogenic seizure | 10.63 | 9.73 | 17 | 166427 | 1193 | 46518425 |
Chronic papillomatous dermatitis | 10.59 | 9.73 | 5 | 166439 | 60 | 46519558 |
Adverse drug reaction | 10.57 | 9.73 | 104 | 166340 | 44258 | 46475360 |
Drug level above therapeutic | 10.57 | 9.73 | 32 | 166412 | 3477 | 46516141 |
Reduced facial expression | 10.52 | 9.73 | 17 | 166427 | 1203 | 46518415 |
Automatism | 10.52 | 9.73 | 5 | 166439 | 61 | 46519557 |
Chronic kidney disease | 10.52 | 9.73 | 94 | 166350 | 40777 | 46478841 |
Hypoaesthesia oral | 10.46 | 9.73 | 69 | 166375 | 10490 | 46509128 |
Thrombosis | 10.41 | 9.73 | 139 | 166305 | 55930 | 46463688 |
Blood ethanol increased | 10.38 | 9.73 | 5 | 166439 | 63 | 46519555 |
Bone decalcification | 10.34 | 9.73 | 4 | 166440 | 28 | 46519590 |
Temperature intolerance | 10.31 | 9.73 | 54 | 166390 | 7553 | 46512065 |
Pancreatolithiasis | 10.31 | 9.73 | 8 | 166436 | 247 | 46519371 |
Poor quality sleep | 10.24 | 9.73 | 91 | 166353 | 15162 | 46504456 |
Haematotoxicity | 10.22 | 9.73 | 6 | 166438 | 6927 | 46512691 |
Basal cell carcinoma | 10.21 | 9.73 | 38 | 166406 | 20449 | 46499169 |
Alcohol poisoning | 10.20 | 9.73 | 24 | 166420 | 2244 | 46517374 |
Nephrectomy | 10.18 | 9.73 | 11 | 166433 | 524 | 46519094 |
Affective disorder | 10.17 | 9.73 | 39 | 166405 | 4776 | 46514842 |
Subarachnoid haemorrhage | 10.14 | 9.73 | 15 | 166429 | 11138 | 46508480 |
Hypoventilation | 10.13 | 9.73 | 35 | 166409 | 4075 | 46515543 |
Hypnopompic hallucination | 10.11 | 9.73 | 4 | 166440 | 30 | 46519588 |
Localised infection | 10.09 | 9.73 | 47 | 166397 | 23754 | 46495864 |
Infantile spasms | 10.09 | 9.73 | 8 | 166436 | 255 | 46519363 |
Breast cancer metastatic | 10.08 | 9.73 | 21 | 166423 | 13657 | 46505961 |
Myelodysplastic syndrome | 10.06 | 9.73 | 26 | 166418 | 15685 | 46503933 |
Obsessive-compulsive symptom | 10.00 | 9.73 | 4 | 166440 | 31 | 46519587 |
Somnambulism | 9.99 | 9.73 | 40 | 166404 | 4997 | 46514621 |
Body height increased | 9.97 | 9.73 | 5 | 166439 | 69 | 46519549 |
Respiratory rate decreased | 9.97 | 9.73 | 29 | 166415 | 3081 | 46516537 |
Therapeutic product ineffective | 9.96 | 9.73 | 15 | 166429 | 999 | 46518619 |
Oral pain | 9.91 | 9.73 | 50 | 166394 | 24747 | 46494871 |
Homeless | 9.89 | 9.73 | 4 | 166440 | 32 | 46519586 |
Toxic leukoencephalopathy | 9.88 | 9.73 | 11 | 166433 | 542 | 46519076 |
Soliloquy | 9.86 | 9.73 | 7 | 166437 | 188 | 46519430 |
Cushingoid | 9.86 | 9.73 | 5 | 166439 | 6261 | 46513357 |
Myelocyte count increased | 9.83 | 9.73 | 9 | 166435 | 350 | 46519268 |
Epstein-Barr virus infection | 9.82 | 9.73 | 6 | 166438 | 6778 | 46512840 |
Arthritis infective | 9.82 | 9.73 | 3 | 166441 | 5110 | 46514508 |
Electrocardiogram QRS complex prolonged | 9.81 | 9.73 | 42 | 166402 | 5407 | 46514211 |
Narcolepsy | 9.79 | 9.73 | 16 | 166428 | 1143 | 46518475 |
Muscle contractions involuntary | 9.79 | 9.73 | 22 | 166422 | 1996 | 46517622 |
Alcohol abuse | 9.78 | 9.73 | 23 | 166421 | 2149 | 46517469 |
Retinal detachment | 9.78 | 9.73 | 3 | 166441 | 5097 | 46514521 |
Hospitalisation | 9.74 | 9.73 | 163 | 166281 | 63222 | 46456396 |
Cytokine release syndrome | 9.74 | 9.73 | 5 | 166439 | 6218 | 46513400 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug abuse | 829.36 | 10.36 | 1116 | 87895 | 80956 | 29782511 |
Completed suicide | 709.09 | 10.36 | 1148 | 87863 | 98344 | 29765123 |
Toxicity to various agents | 520.83 | 10.36 | 1421 | 87590 | 175762 | 29687705 |
Depression | 467.28 | 10.36 | 907 | 88104 | 89530 | 29773937 |
Sopor | 287.67 | 10.36 | 248 | 88763 | 10743 | 29852724 |
Somnolence | 282.27 | 10.36 | 775 | 88236 | 95988 | 29767479 |
Anxiety | 266.27 | 10.36 | 724 | 88287 | 89147 | 29774320 |
Overdose | 256.44 | 10.36 | 686 | 88325 | 83651 | 29779816 |
Seizure | 244.01 | 10.36 | 744 | 88267 | 97731 | 29765736 |
Intentional overdose | 221.10 | 10.36 | 422 | 88589 | 41059 | 29822408 |
Respiratory arrest | 220.58 | 10.36 | 347 | 88664 | 28911 | 29834556 |
Neuroleptic malignant syndrome | 205.74 | 10.36 | 248 | 88763 | 16047 | 29847420 |
Suicide attempt | 203.83 | 10.36 | 380 | 88631 | 36317 | 29827150 |
Sedation | 176.10 | 10.36 | 230 | 88781 | 16143 | 29847324 |
Agitation | 175.59 | 10.36 | 451 | 88560 | 53622 | 29809845 |
Suicidal ideation | 170.21 | 10.36 | 349 | 88662 | 35765 | 29827702 |
Aggression | 160.36 | 10.36 | 345 | 88666 | 36562 | 29826905 |
Intentional self-injury | 151.64 | 10.36 | 194 | 88817 | 13338 | 29850129 |
Cardio-respiratory arrest | 147.42 | 10.36 | 439 | 88572 | 56867 | 29806600 |
Intentional product misuse | 139.21 | 10.36 | 314 | 88697 | 34353 | 29829114 |
Coma | 138.19 | 10.36 | 344 | 88667 | 40105 | 29823362 |
Anaemia | 137.18 | 10.36 | 256 | 88755 | 207736 | 29655731 |
Febrile neutropenia | 135.72 | 10.36 | 74 | 88937 | 106619 | 29756848 |
Psychotic disorder | 129.82 | 10.36 | 231 | 88780 | 21284 | 29842183 |
Drug withdrawal syndrome | 127.73 | 10.36 | 219 | 88792 | 19590 | 29843877 |
Acute kidney injury | 125.02 | 10.36 | 408 | 88603 | 273434 | 29590033 |
Drug interaction | 122.85 | 10.36 | 1012 | 87999 | 198556 | 29664911 |
Drug dependence | 118.79 | 10.36 | 221 | 88790 | 21074 | 29842393 |
Abnormal behaviour | 116.45 | 10.36 | 244 | 88767 | 25379 | 29838088 |
Status epilepticus | 113.59 | 10.36 | 152 | 88859 | 10920 | 29852547 |
Poisoning | 104.35 | 10.36 | 148 | 88863 | 11234 | 29852233 |
Dyspnoea | 103.76 | 10.36 | 575 | 88436 | 332720 | 29530747 |
Substance abuse | 103.66 | 10.36 | 116 | 88895 | 6924 | 29856543 |
Insomnia | 102.93 | 10.36 | 548 | 88463 | 92788 | 29770679 |
Interstitial lung disease | 102.88 | 10.36 | 26 | 88985 | 60171 | 29803296 |
Dyskinesia | 98.14 | 10.36 | 207 | 88804 | 21627 | 29841840 |
Panic attack | 94.96 | 10.36 | 123 | 88888 | 8558 | 29854909 |
Cardiac arrest | 91.59 | 10.36 | 529 | 88482 | 92321 | 29771146 |
Speech disorder | 90.66 | 10.36 | 215 | 88796 | 24297 | 29839170 |
Depressed level of consciousness | 88.18 | 10.36 | 282 | 88729 | 37940 | 29825527 |
Parkinsonism | 87.46 | 10.36 | 108 | 88903 | 7161 | 29856306 |
Thrombocytopenia | 84.75 | 10.36 | 175 | 88836 | 136869 | 29726598 |
Pancytopenia | 84.40 | 10.36 | 77 | 88934 | 84975 | 29778492 |
Diarrhoea | 81.24 | 10.36 | 621 | 88390 | 333482 | 29529985 |
Granulocytopenia | 80.60 | 10.36 | 96 | 88915 | 6130 | 29857337 |
Sepsis | 77.62 | 10.36 | 203 | 88808 | 146192 | 29717275 |
Malignant neoplasm progression | 77.16 | 10.36 | 61 | 88950 | 72226 | 29791241 |
Ataxia | 76.89 | 10.36 | 129 | 88882 | 11333 | 29852134 |
Hallucination | 75.18 | 10.36 | 317 | 88694 | 48742 | 29814725 |
Paranoia | 74.20 | 10.36 | 119 | 88892 | 10069 | 29853398 |
Dystonia | 74.14 | 10.36 | 116 | 88895 | 9611 | 29853856 |
Drug withdrawal convulsions | 74.10 | 10.36 | 45 | 88966 | 1114 | 29862353 |
Miosis | 74.08 | 10.36 | 103 | 88908 | 7673 | 29855794 |
Renal failure | 71.31 | 10.36 | 175 | 88836 | 128791 | 29734676 |
Serotonin syndrome | 69.51 | 10.36 | 160 | 88851 | 17731 | 29845736 |
Akathisia | 68.27 | 10.36 | 86 | 88925 | 5818 | 29857649 |
Cardiac failure | 66.85 | 10.36 | 90 | 88921 | 83328 | 29780139 |
Pneumonia | 66.69 | 10.36 | 654 | 88357 | 333652 | 29529815 |
Myocardial infarction | 65.96 | 10.36 | 175 | 88836 | 125450 | 29738017 |
Salivary hypersecretion | 65.86 | 10.36 | 96 | 88915 | 7470 | 29855997 |
Restlessness | 65.68 | 10.36 | 181 | 88830 | 22418 | 29841049 |
Thinking abnormal | 65.65 | 10.36 | 80 | 88931 | 5231 | 29858236 |
Tremor | 64.53 | 10.36 | 414 | 88597 | 74949 | 29788518 |
Muscle rigidity | 64.24 | 10.36 | 112 | 88899 | 10149 | 29853318 |
Rash | 62.86 | 10.36 | 325 | 88686 | 191564 | 29671903 |
Hallucination, auditory | 60.19 | 10.36 | 106 | 88905 | 9683 | 29853784 |
Hyperkalaemia | 59.47 | 10.36 | 65 | 88946 | 65945 | 29797522 |
Epilepsy | 59.07 | 10.36 | 162 | 88849 | 20007 | 29843460 |
Psychomotor hyperactivity | 58.45 | 10.36 | 95 | 88916 | 8129 | 29855338 |
Anger | 57.79 | 10.36 | 112 | 88899 | 11008 | 29852459 |
Memory impairment | 56.78 | 10.36 | 240 | 88771 | 36934 | 29826533 |
Disease progression | 56.41 | 10.36 | 94 | 88917 | 79780 | 29783687 |
Generalised tonic-clonic seizure | 55.25 | 10.36 | 155 | 88856 | 19396 | 29844071 |
Respiratory depression | 55.13 | 10.36 | 112 | 88899 | 11391 | 29852076 |
Irritability | 54.92 | 10.36 | 172 | 88839 | 22878 | 29840589 |
Bradykinesia | 54.15 | 10.36 | 57 | 88954 | 3173 | 29860294 |
Pneumonia aspiration | 53.94 | 10.36 | 239 | 88772 | 37541 | 29825926 |
Drug use disorder | 53.89 | 10.36 | 57 | 88954 | 3191 | 29860276 |
Atrial fibrillation | 53.48 | 10.36 | 155 | 88856 | 107969 | 29755498 |
Tardive dyskinesia | 52.75 | 10.36 | 70 | 88941 | 4987 | 29858480 |
Pyrexia | 52.59 | 10.36 | 591 | 88420 | 293898 | 29569569 |
Delusion | 51.94 | 10.36 | 112 | 88899 | 11877 | 29851590 |
Platelet count decreased | 51.86 | 10.36 | 153 | 88858 | 105976 | 29757491 |
Gastrointestinal haemorrhage | 51.16 | 10.36 | 107 | 88904 | 83339 | 29780128 |
Plasma cell myeloma | 51.14 | 10.36 | 50 | 88961 | 53412 | 29810055 |
Neutropenia | 50.84 | 10.36 | 203 | 88808 | 128337 | 29735130 |
Housebound | 50.82 | 10.36 | 20 | 88991 | 181 | 29863286 |
Disturbance in attention | 50.77 | 10.36 | 163 | 88848 | 21966 | 29841501 |
Psychiatric decompensation | 50.09 | 10.36 | 37 | 88974 | 1278 | 29862189 |
Gait disturbance | 50.07 | 10.36 | 387 | 88624 | 74390 | 29789077 |
Nervousness | 49.79 | 10.36 | 109 | 88902 | 11679 | 29851788 |
Pleural effusion | 49.71 | 10.36 | 90 | 88921 | 73976 | 29789491 |
Renal impairment | 49.08 | 10.36 | 111 | 88900 | 84073 | 29779394 |
Cardiac failure congestive | 48.64 | 10.36 | 112 | 88899 | 84295 | 29779172 |
Confusional state | 48.58 | 10.36 | 613 | 88398 | 134221 | 29729246 |
Cognitive disorder | 47.71 | 10.36 | 167 | 88844 | 23523 | 29839944 |
Behaviour disorder | 46.69 | 10.36 | 46 | 88965 | 2366 | 29861101 |
Mental disorder | 46.54 | 10.36 | 115 | 88896 | 13334 | 29850133 |
Loss of personal independence in daily activities | 46.16 | 10.36 | 155 | 88856 | 21380 | 29842087 |
Stomatitis | 45.71 | 10.36 | 27 | 88984 | 37252 | 29826215 |
Cerebrovascular accident | 44.76 | 10.36 | 115 | 88896 | 83362 | 29780105 |
Depression suicidal | 44.38 | 10.36 | 34 | 88977 | 1242 | 29862225 |
Disorientation | 44.27 | 10.36 | 198 | 88813 | 31220 | 29832247 |
Hyperprolactinaemia | 44.00 | 10.36 | 33 | 88978 | 1167 | 29862300 |
Haemoglobin decreased | 43.97 | 10.36 | 182 | 88829 | 113916 | 29749551 |
Catatonia | 43.20 | 10.36 | 59 | 88952 | 4321 | 29859146 |
Device interaction | 41.99 | 10.36 | 22 | 88989 | 406 | 29863061 |
Rheumatoid arthritis | 41.19 | 10.36 | 37 | 88974 | 41160 | 29822307 |
Withdrawal syndrome | 40.85 | 10.36 | 98 | 88913 | 11152 | 29852315 |
Psychomotor skills impaired | 40.67 | 10.36 | 39 | 88972 | 1940 | 29861527 |
Dysarthria | 40.62 | 10.36 | 189 | 88822 | 30301 | 29833166 |
General physical health deterioration | 40.03 | 10.36 | 157 | 88854 | 99787 | 29763680 |
Drug abuser | 40.00 | 10.36 | 57 | 88954 | 4344 | 29859123 |
Drooling | 39.99 | 10.36 | 47 | 88964 | 2958 | 29860509 |
Tearfulness | 39.70 | 10.36 | 35 | 88976 | 1561 | 29861906 |
Obsessive-compulsive disorder | 39.67 | 10.36 | 55 | 88956 | 4086 | 29859381 |
Acute myocardial infarction | 39.54 | 10.36 | 60 | 88951 | 52879 | 29810588 |
Disinhibition | 39.15 | 10.36 | 38 | 88973 | 1919 | 29861548 |
Prescribed overdose | 38.26 | 10.36 | 81 | 88930 | 8480 | 29854987 |
Joint swelling | 38.25 | 10.36 | 50 | 88961 | 46896 | 29816571 |
Medication error | 38.12 | 10.36 | 143 | 88868 | 20829 | 29842638 |
Agoraphobia | 37.63 | 10.36 | 17 | 88994 | 223 | 29863244 |
Infusion related reaction | 37.57 | 10.36 | 39 | 88972 | 40525 | 29822942 |
Altered state of consciousness | 37.19 | 10.36 | 137 | 88874 | 19782 | 29843685 |
Mental impairment | 37.17 | 10.36 | 84 | 88927 | 9193 | 29854274 |
Bradyphrenia | 37.07 | 10.36 | 52 | 88959 | 3905 | 29859562 |
Mania | 36.81 | 10.36 | 83 | 88928 | 9071 | 29854396 |
Angioedema | 36.69 | 10.36 | 29 | 88982 | 34355 | 29829112 |
On and off phenomenon | 36.47 | 10.36 | 44 | 88967 | 2847 | 29860620 |
Psychomotor retardation | 36.40 | 10.36 | 40 | 88971 | 2339 | 29861128 |
Blood creatinine increased | 36.29 | 10.36 | 144 | 88867 | 91231 | 29772236 |
Postmortem blood drug level increased | 35.64 | 10.36 | 14 | 88997 | 126 | 29863341 |
Postmortem blood drug level abnormal | 35.34 | 10.36 | 16 | 88995 | 211 | 29863256 |
Lactic acidosis | 35.01 | 10.36 | 25 | 88986 | 31188 | 29832279 |
Infection | 34.99 | 10.36 | 117 | 88894 | 77957 | 29785510 |
Oedema peripheral | 34.72 | 10.36 | 179 | 88832 | 105653 | 29757814 |
Movement disorder | 34.72 | 10.36 | 85 | 88926 | 9798 | 29853669 |
Bone marrow failure | 34.54 | 10.36 | 23 | 88988 | 29762 | 29833705 |
Cough | 34.04 | 10.36 | 226 | 88785 | 125416 | 29738051 |
Cytomegalovirus infection | 33.77 | 10.36 | 14 | 88997 | 23660 | 29839807 |
Cerebral haemorrhage | 33.53 | 10.36 | 29 | 88982 | 32858 | 29830609 |
Loss of consciousness | 33.46 | 10.36 | 372 | 88639 | 79003 | 29784464 |
Blood creatine phosphokinase increased | 33.36 | 10.36 | 234 | 88777 | 43614 | 29819853 |
Drug ineffective | 33.24 | 10.36 | 1280 | 87731 | 339107 | 29524360 |
Unresponsive to stimuli | 33.18 | 10.36 | 161 | 88850 | 26258 | 29837209 |
Screaming | 32.73 | 10.36 | 29 | 88982 | 1302 | 29862165 |
Toxicologic test abnormal | 32.16 | 10.36 | 21 | 88990 | 592 | 29862875 |
Mydriasis | 32.07 | 10.36 | 62 | 88949 | 6081 | 29857386 |
Abnormal dreams | 31.98 | 10.36 | 73 | 88938 | 8042 | 29855425 |
Fall | 31.95 | 10.36 | 736 | 88275 | 181136 | 29682331 |
Drug hypersensitivity | 31.87 | 10.36 | 101 | 88910 | 68418 | 29795049 |
Restless legs syndrome | 31.86 | 10.36 | 66 | 88945 | 6806 | 29856661 |
Ascites | 31.65 | 10.36 | 36 | 88975 | 35885 | 29827582 |
Myoclonus | 31.39 | 10.36 | 99 | 88912 | 13213 | 29850254 |
Psychogenic seizure | 31.24 | 10.36 | 16 | 88995 | 281 | 29863186 |
Coronary artery disease | 31.08 | 10.36 | 63 | 88948 | 49649 | 29813818 |
Drug diversion | 30.96 | 10.36 | 24 | 88987 | 892 | 29862575 |
Schizophrenia | 30.92 | 10.36 | 77 | 88934 | 8971 | 29854496 |
Poor quality sleep | 30.63 | 10.36 | 67 | 88944 | 7174 | 29856293 |
Feeling of despair | 30.42 | 10.36 | 24 | 88987 | 916 | 29862551 |
Myelodysplastic syndrome | 30.39 | 10.36 | 9 | 89002 | 18769 | 29844698 |
Choreoathetosis | 30.35 | 10.36 | 24 | 88987 | 919 | 29862548 |
Decreased appetite | 30.28 | 10.36 | 292 | 88719 | 149618 | 29713849 |
Melaena | 30.25 | 10.36 | 31 | 88980 | 32406 | 29831061 |
Hallucination, visual | 30.23 | 10.36 | 111 | 88900 | 16002 | 29847465 |
Urticaria | 30.21 | 10.36 | 74 | 88937 | 54532 | 29808935 |
Nausea | 30.16 | 10.36 | 663 | 88348 | 296294 | 29567173 |
Septic shock | 30.11 | 10.36 | 93 | 88918 | 63514 | 29799953 |
Pneumocystis jirovecii pneumonia | 30.00 | 10.36 | 7 | 89004 | 17113 | 29846354 |
Product substitution issue | 29.77 | 10.36 | 81 | 88930 | 9954 | 29853513 |
Crying | 29.76 | 10.36 | 57 | 88954 | 5552 | 29857915 |
Dyspnoea exertional | 29.62 | 10.36 | 37 | 88974 | 35393 | 29828074 |
Illness anxiety disorder | 29.58 | 10.36 | 13 | 88998 | 159 | 29863308 |
Vessel puncture site erythema | 28.93 | 10.36 | 6 | 89005 | 0 | 29863467 |
Myoclonic epilepsy | 28.70 | 10.36 | 22 | 88989 | 804 | 29862663 |
Contraindicated product administered | 28.37 | 10.36 | 8 | 89003 | 17223 | 29846244 |
Generalised anxiety disorder | 28.35 | 10.36 | 20 | 88991 | 642 | 29862825 |
Tension | 28.15 | 10.36 | 29 | 88982 | 1574 | 29861893 |
Electroencephalogram abnormal | 28.12 | 10.36 | 35 | 88976 | 2339 | 29861128 |
Multiple-drug resistance | 28.08 | 10.36 | 39 | 88972 | 2902 | 29860565 |
Panic disorder | 27.71 | 10.36 | 25 | 88986 | 1150 | 29862317 |
Drug screen positive | 27.45 | 10.36 | 48 | 88963 | 4359 | 29859108 |
Sleep apnoea syndrome | 27.43 | 10.36 | 111 | 88900 | 16746 | 29846721 |
Middle insomnia | 27.41 | 10.36 | 56 | 88955 | 5717 | 29857750 |
Pruritus | 27.04 | 10.36 | 223 | 88788 | 117981 | 29745486 |
Haematuria | 27.03 | 10.36 | 58 | 88953 | 44776 | 29818691 |
Dystonic tremor | 26.90 | 10.36 | 11 | 89000 | 111 | 29863356 |
Mucosal inflammation | 26.39 | 10.36 | 31 | 88980 | 30463 | 29833004 |
Affect lability | 26.37 | 10.36 | 41 | 88970 | 3377 | 29860090 |
Accidental overdose | 26.36 | 10.36 | 116 | 88895 | 18159 | 29845308 |
Gastrointestinal hypermotility | 26.23 | 10.36 | 11 | 89000 | 119 | 29863348 |
Bronchopulmonary aspergillosis | 26.02 | 10.36 | 3 | 89008 | 12281 | 29851186 |
Bipolar disorder | 25.99 | 10.36 | 43 | 88968 | 3733 | 29859734 |
Cerebral infarction | 25.99 | 10.36 | 24 | 88987 | 26349 | 29837118 |
Blunted affect | 25.98 | 10.36 | 14 | 88997 | 274 | 29863193 |
Dysphoria | 25.97 | 10.36 | 32 | 88979 | 2116 | 29861351 |
Tachyphrenia | 25.95 | 10.36 | 23 | 88988 | 1033 | 29862434 |
Drug tolerance | 25.81 | 10.36 | 32 | 88979 | 2130 | 29861337 |
Depressive symptom | 25.76 | 10.36 | 28 | 88983 | 1617 | 29861850 |
Proteinuria | 25.66 | 10.36 | 8 | 89003 | 16137 | 29847330 |
Torticollis | 25.60 | 10.36 | 23 | 88988 | 1052 | 29862415 |
Talipes | 25.34 | 10.36 | 28 | 88983 | 1647 | 29861820 |
Postictal paralysis | 25.14 | 10.36 | 11 | 89000 | 133 | 29863334 |
Blood creatine phosphokinase | 24.99 | 10.36 | 9 | 89002 | 62 | 29863405 |
Erythema | 24.83 | 10.36 | 132 | 88879 | 77319 | 29786148 |
Anaphylactic reaction | 24.69 | 10.36 | 28 | 88983 | 27954 | 29835513 |
Weight increased | 24.59 | 10.36 | 335 | 88676 | 74578 | 29788889 |
Stoma site discharge | 24.30 | 10.36 | 26 | 88985 | 1475 | 29861992 |
Colitis | 23.92 | 10.36 | 34 | 88977 | 30786 | 29832681 |
Bradypnoea | 23.85 | 10.36 | 29 | 88982 | 1892 | 29861575 |
Drug level above therapeutic | 23.73 | 10.36 | 36 | 88975 | 2903 | 29860564 |
Purpura fulminans | 23.46 | 10.36 | 10 | 89001 | 113 | 29863354 |
Treatment failure | 23.38 | 10.36 | 42 | 88969 | 34637 | 29828830 |
Multiple organ dysfunction syndrome | 23.37 | 10.36 | 103 | 88908 | 63384 | 29800083 |
Atonic seizures | 23.27 | 10.36 | 11 | 89000 | 161 | 29863306 |
Injection site exfoliation | 22.71 | 10.36 | 6 | 89005 | 11 | 29863456 |
Withdrawal arrhythmia | 22.57 | 10.36 | 7 | 89004 | 28 | 29863439 |
Hypotonia | 22.56 | 10.36 | 58 | 88953 | 6890 | 29856577 |
Nightmare | 22.49 | 10.36 | 83 | 88928 | 11993 | 29851474 |
International normalised ratio increased | 22.45 | 10.36 | 70 | 88941 | 47669 | 29815798 |
Personality disorder | 22.31 | 10.36 | 22 | 88989 | 1133 | 29862334 |
Amnesia | 22.27 | 10.36 | 136 | 88875 | 24185 | 29839282 |
Acute myeloid leukaemia | 22.13 | 10.36 | 13 | 88998 | 17993 | 29845474 |
Feeling abnormal | 22.11 | 10.36 | 262 | 88749 | 56494 | 29806973 |
Injection site dryness | 22.05 | 10.36 | 6 | 89005 | 13 | 29863454 |
Pulmonary fibrosis | 21.71 | 10.36 | 10 | 89001 | 15880 | 29847587 |
Oedema | 21.69 | 10.36 | 61 | 88950 | 42932 | 29820535 |
Gambling disorder | 21.59 | 10.36 | 27 | 88984 | 1813 | 29861654 |
Drug screen negative | 21.52 | 10.36 | 12 | 88999 | 252 | 29863215 |
Physical assault | 21.40 | 10.36 | 22 | 88989 | 1191 | 29862276 |
Neutropenic sepsis | 21.36 | 10.36 | 4 | 89007 | 11405 | 29852062 |
Ehlers-Danlos syndrome | 21.31 | 10.36 | 7 | 89004 | 35 | 29863432 |
Balance disorder | 21.23 | 10.36 | 183 | 88828 | 36310 | 29827157 |
Congenital melanocytic naevus | 21.18 | 10.36 | 6 | 89005 | 16 | 29863451 |
Antidepressant drug level increased | 21.17 | 10.36 | 9 | 89002 | 101 | 29863366 |
Post-traumatic stress disorder | 21.06 | 10.36 | 25 | 88986 | 1590 | 29861877 |
Blood bilirubin increased | 20.77 | 10.36 | 49 | 88962 | 36587 | 29826880 |
Device dislocation | 20.65 | 10.36 | 46 | 88965 | 4985 | 29858482 |
Cerebral artery thrombosis | 20.61 | 10.36 | 15 | 88996 | 506 | 29862961 |
Neuropathy peripheral | 20.48 | 10.36 | 124 | 88887 | 70351 | 29793116 |
Dysmetria | 20.37 | 10.36 | 13 | 88998 | 352 | 29863115 |
Apathy | 20.21 | 10.36 | 52 | 88959 | 6180 | 29857287 |
Arthralgia | 20.20 | 10.36 | 283 | 88728 | 135508 | 29727959 |
Hypertonia | 20.19 | 10.36 | 42 | 88969 | 4343 | 29859124 |
Depressed mood | 20.11 | 10.36 | 102 | 88909 | 16927 | 29846540 |
Hyperammonaemia | 19.95 | 10.36 | 48 | 88963 | 5472 | 29857995 |
Multiple sclerosis | 19.93 | 10.36 | 57 | 88954 | 7210 | 29856257 |
Persecutory delusion | 19.87 | 10.36 | 28 | 88983 | 2112 | 29861355 |
Spasmodic dysphonia | 19.81 | 10.36 | 8 | 89003 | 78 | 29863389 |
Coordination abnormal | 19.74 | 10.36 | 57 | 88954 | 7248 | 29856219 |
Hepatotoxicity | 19.74 | 10.36 | 15 | 88996 | 18130 | 29845337 |
Electrocardiogram QRS complex prolonged | 19.73 | 10.36 | 41 | 88970 | 4236 | 29859231 |
Brain scan abnormal | 19.70 | 10.36 | 16 | 88995 | 637 | 29862830 |
Multiple sclerosis relapse | 19.68 | 10.36 | 74 | 88937 | 10788 | 29852679 |
Heat stroke | 19.52 | 10.36 | 18 | 88993 | 852 | 29862615 |
Osteonecrosis of jaw | 19.49 | 10.36 | 16 | 88995 | 18602 | 29844865 |
Drug level decreased | 19.41 | 10.36 | 49 | 88962 | 5756 | 29857711 |
Bruxism | 19.33 | 10.36 | 22 | 88989 | 1337 | 29862130 |
Haematemesis | 19.27 | 10.36 | 30 | 88981 | 26173 | 29837294 |
Tubulointerstitial nephritis | 19.20 | 10.36 | 15 | 88996 | 17876 | 29845591 |
Reduced facial expression | 19.19 | 10.36 | 17 | 88994 | 763 | 29862704 |
Cogwheel rigidity | 18.96 | 10.36 | 20 | 88991 | 1116 | 29862351 |
Terminal insomnia | 18.85 | 10.36 | 13 | 88998 | 402 | 29863065 |
Hypomania | 18.73 | 10.36 | 28 | 88983 | 2228 | 29861239 |
Hypokalaemia | 18.73 | 10.36 | 81 | 88930 | 50111 | 29813356 |
Extrapyramidal disorder | 18.68 | 10.36 | 72 | 88939 | 10621 | 29852846 |
Blood prolactin increased | 18.52 | 10.36 | 22 | 88989 | 1400 | 29862067 |
Partial seizures | 18.43 | 10.36 | 37 | 88974 | 3730 | 29859737 |
Exposure via ingestion | 18.33 | 10.36 | 30 | 88981 | 2581 | 29860886 |
Poverty of speech | 18.28 | 10.36 | 10 | 89001 | 202 | 29863265 |
Aspergillus infection | 18.25 | 10.36 | 4 | 89007 | 10210 | 29853257 |
Homicidal ideation | 18.25 | 10.36 | 29 | 88982 | 2434 | 29861033 |
Laboratory test abnormal | 18.24 | 10.36 | 15 | 88996 | 17427 | 29846040 |
Depersonalisation/derealisation disorder | 18.23 | 10.36 | 14 | 88997 | 513 | 29862954 |
Drug intolerance | 18.21 | 10.36 | 71 | 88940 | 45220 | 29818247 |
Bacteraemia | 18.06 | 10.36 | 12 | 88999 | 15548 | 29847919 |
Major depression | 17.91 | 10.36 | 38 | 88973 | 3984 | 29859483 |
Dehydration | 17.83 | 10.36 | 259 | 88752 | 123280 | 29740187 |
Victim of crime | 17.77 | 10.36 | 11 | 89000 | 282 | 29863185 |
Stereotypy | 17.75 | 10.36 | 14 | 88997 | 534 | 29862933 |
Hepatic cirrhosis | 17.69 | 10.36 | 13 | 88998 | 15986 | 29847481 |
Haematochezia | 17.68 | 10.36 | 48 | 88963 | 34174 | 29829293 |
Developmental regression | 17.65 | 10.36 | 6 | 89005 | 34 | 29863433 |
Electrocardiogram QT shortened | 17.63 | 10.36 | 9 | 89002 | 157 | 29863310 |
Asthenia | 17.58 | 10.36 | 512 | 88499 | 220778 | 29642689 |
Pulmonary embolism | 17.58 | 10.36 | 148 | 88863 | 77987 | 29785480 |
Sleep-related eating disorder | 17.53 | 10.36 | 11 | 89000 | 289 | 29863178 |
Psoriasis | 17.49 | 10.36 | 66 | 88945 | 42440 | 29821027 |
Freezing phenomenon | 17.48 | 10.36 | 25 | 88986 | 1911 | 29861556 |
Haemorrhage | 17.42 | 10.36 | 74 | 88937 | 46005 | 29817462 |
Nephropathy toxic | 17.40 | 10.36 | 5 | 89006 | 10634 | 29852833 |
Frustration tolerance decreased | 17.15 | 10.36 | 25 | 88986 | 1945 | 29861522 |
Angina pectoris | 17.12 | 10.36 | 39 | 88972 | 29479 | 29833988 |
Renal hypertension | 17.08 | 10.36 | 9 | 89002 | 168 | 29863299 |
Obsessive-compulsive personality disorder | 17.04 | 10.36 | 9 | 89002 | 169 | 29863298 |
Myelocyte count increased | 17.00 | 10.36 | 7 | 89004 | 72 | 29863395 |
Lennox-Gastaut syndrome | 16.96 | 10.36 | 6 | 89005 | 39 | 29863428 |
Language disorder | 16.90 | 10.36 | 20 | 88991 | 1268 | 29862199 |
Panic reaction | 16.89 | 10.36 | 21 | 88990 | 1402 | 29862065 |
Priapism | 16.88 | 10.36 | 41 | 88970 | 4702 | 29858765 |
Hyperthermia | 16.83 | 10.36 | 67 | 88944 | 10032 | 29853435 |
Physical abuse | 16.75 | 10.36 | 5 | 89006 | 17 | 29863450 |
Bipolar I disorder | 16.73 | 10.36 | 16 | 88995 | 793 | 29862674 |
Posture abnormal | 16.73 | 10.36 | 24 | 88987 | 1840 | 29861627 |
Hypertension | 16.63 | 10.36 | 257 | 88754 | 121097 | 29742370 |
Basal cell carcinoma | 16.58 | 10.36 | 14 | 88997 | 16054 | 29847413 |
Palmar-plantar erythrodysaesthesia syndrome | 16.55 | 10.36 | 12 | 88999 | 14858 | 29848609 |
Muscle spasticity | 16.53 | 10.36 | 43 | 88968 | 5145 | 29858322 |
Brain malformation | 16.51 | 10.36 | 7 | 89004 | 78 | 29863389 |
Thrombosis | 16.47 | 10.36 | 67 | 88944 | 42164 | 29821303 |
Posterior reversible encephalopathy syndrome | 16.41 | 10.36 | 3 | 89008 | 8704 | 29854763 |
Sexual dysfunction | 16.39 | 10.36 | 47 | 88964 | 5954 | 29857513 |
Encephalitis toxic | 16.34 | 10.36 | 8 | 89003 | 127 | 29863340 |
Sedation complication | 16.32 | 10.36 | 16 | 88995 | 818 | 29862649 |
Peritonitis | 16.17 | 10.36 | 24 | 88987 | 21351 | 29842116 |
Thrombotic microangiopathy | 16.16 | 10.36 | 3 | 89008 | 8607 | 29854860 |
Allodynia | 15.98 | 10.36 | 14 | 88997 | 619 | 29862848 |
Anaphylactic shock | 15.96 | 10.36 | 11 | 89000 | 13982 | 29849485 |
HIV peripheral neuropathy | 15.89 | 10.36 | 6 | 89005 | 48 | 29863419 |
Liver disorder | 15.87 | 10.36 | 41 | 88970 | 29681 | 29833786 |
Galactorrhoea | 15.84 | 10.36 | 11 | 89000 | 344 | 29863123 |
Impulsive behaviour | 15.76 | 10.36 | 24 | 88987 | 1941 | 29861526 |
Brain injury | 15.68 | 10.36 | 44 | 88967 | 5504 | 29857963 |
Type 2 diabetes mellitus | 15.67 | 10.36 | 81 | 88930 | 13541 | 29849926 |
Gout | 15.64 | 10.36 | 17 | 88994 | 17298 | 29846169 |
Asterixis | 15.62 | 10.36 | 19 | 88992 | 1240 | 29862227 |
Myocarditis | 15.56 | 10.36 | 65 | 88946 | 9946 | 29853521 |
Epistaxis | 15.51 | 10.36 | 93 | 88918 | 52888 | 29810579 |
Shock haemorrhagic | 15.48 | 10.36 | 5 | 89006 | 9860 | 29853607 |
Upper gastrointestinal haemorrhage | 15.46 | 10.36 | 26 | 88985 | 22002 | 29841465 |
Muscle contracture | 15.43 | 10.36 | 18 | 88993 | 1124 | 29862343 |
Vomiting | 15.42 | 10.36 | 517 | 88494 | 219301 | 29644166 |
Stress | 15.39 | 10.36 | 108 | 88903 | 20127 | 29843340 |
Increased appetite | 15.34 | 10.36 | 44 | 88967 | 5573 | 29857894 |
Deep vein thrombosis | 15.29 | 10.36 | 111 | 88900 | 60390 | 29803077 |
Phaeochromocytoma malignant | 15.28 | 10.36 | 6 | 89005 | 54 | 29863413 |
Parkinsonian gait | 15.18 | 10.36 | 12 | 88999 | 459 | 29863008 |
Arthritis | 15.18 | 10.36 | 31 | 88980 | 24370 | 29839097 |
Anhidrosis | 15.15 | 10.36 | 7 | 89004 | 97 | 29863370 |
Infantile spasms | 15.10 | 10.36 | 10 | 89001 | 289 | 29863178 |
Somnambulism | 15.05 | 10.36 | 31 | 88980 | 3183 | 29860284 |
Stoma site erythema | 15.02 | 10.36 | 17 | 88994 | 1027 | 29862440 |
Nasal septum deviation | 15.00 | 10.36 | 16 | 88995 | 904 | 29862563 |
Chills | 14.96 | 10.36 | 140 | 88871 | 72198 | 29791269 |
Hypersomnia | 14.96 | 10.36 | 70 | 88941 | 11246 | 29852221 |
Cluster headache | 14.95 | 10.36 | 13 | 88998 | 569 | 29862898 |
Feeling guilty | 14.95 | 10.36 | 10 | 89001 | 294 | 29863173 |
Blood bicarbonate decreased | 14.77 | 10.36 | 26 | 88985 | 2373 | 29861094 |
Logorrhoea | 14.72 | 10.36 | 24 | 88987 | 2058 | 29861409 |
Red cell distribution width decreased | 14.56 | 10.36 | 8 | 89003 | 163 | 29863304 |
Staphylococcal sepsis | 14.56 | 10.36 | 5 | 89006 | 9486 | 29853981 |
Feeling jittery | 14.49 | 10.36 | 34 | 88977 | 3814 | 29859653 |
Graft versus host disease | 14.48 | 10.36 | 6 | 89005 | 10144 | 29853323 |
Anal spasm | 14.47 | 10.36 | 3 | 89008 | 0 | 29863467 |
Eustachian tube disorder | 14.47 | 10.36 | 3 | 89008 | 0 | 29863467 |
Stoma site extravasation | 14.43 | 10.36 | 8 | 89003 | 166 | 29863301 |
Dependence | 14.40 | 10.36 | 18 | 88993 | 1208 | 29862259 |
Mental status changes | 14.36 | 10.36 | 171 | 88840 | 36908 | 29826559 |
Libido increased | 14.34 | 10.36 | 15 | 88996 | 829 | 29862638 |
Antipsychotic drug level increased | 14.20 | 10.36 | 30 | 88981 | 3136 | 29860331 |
Wrong schedule | 14.14 | 10.36 | 7 | 89004 | 114 | 29863353 |
Withdrawal hypertension | 14.14 | 10.36 | 6 | 89005 | 67 | 29863400 |
Hyperosmolar state | 14.10 | 10.36 | 11 | 89000 | 413 | 29863054 |
Postoperative respiratory failure | 14.06 | 10.36 | 6 | 89005 | 68 | 29863399 |
Cholangitis | 14.05 | 10.36 | 3 | 89008 | 7799 | 29855668 |
Dopamine dysregulation syndrome | 13.98 | 10.36 | 12 | 88999 | 516 | 29862951 |
Cytokine release syndrome | 13.96 | 10.36 | 6 | 89005 | 9927 | 29853540 |
Tooth injury | 13.96 | 10.36 | 14 | 88997 | 736 | 29862731 |
Myalgia | 13.94 | 10.36 | 153 | 88858 | 76514 | 29786953 |
Intensive care unit acquired weakness | 13.93 | 10.36 | 15 | 88996 | 857 | 29862610 |
Ejaculation disorder | 13.91 | 10.36 | 16 | 88995 | 984 | 29862483 |
Locomotive syndrome | 13.78 | 10.36 | 4 | 89007 | 12 | 29863455 |
Clonic convulsion | 13.73 | 10.36 | 12 | 88999 | 529 | 29862938 |
Cholestasis | 13.65 | 10.36 | 34 | 88977 | 24916 | 29838551 |
Self esteem decreased | 13.63 | 10.36 | 12 | 88999 | 534 | 29862933 |
Peripheral swelling | 13.59 | 10.36 | 116 | 88895 | 60958 | 29802509 |
Accommodation disorder | 13.58 | 10.36 | 8 | 89003 | 187 | 29863280 |
Hostility | 13.55 | 10.36 | 15 | 88996 | 884 | 29862583 |
Chronic kidney disease | 13.55 | 10.36 | 62 | 88949 | 37776 | 29825691 |
Product complaint | 13.52 | 10.36 | 43 | 88968 | 5763 | 29857704 |
Drug ineffective for unapproved indication | 13.44 | 10.36 | 66 | 88945 | 10814 | 29852653 |
Accidental death | 13.41 | 10.36 | 23 | 88988 | 2056 | 29861411 |
Erectile dysfunction | 13.41 | 10.36 | 96 | 88915 | 18006 | 29845461 |
Sleep disorder | 13.33 | 10.36 | 121 | 88890 | 24358 | 29839109 |
Central pain syndrome | 13.32 | 10.36 | 7 | 89004 | 130 | 29863337 |
Death | 13.32 | 10.36 | 899 | 88112 | 356384 | 29507083 |
Herpes zoster | 13.31 | 10.36 | 45 | 88966 | 29898 | 29833569 |
Haemorrhage intracranial | 13.31 | 10.36 | 15 | 88996 | 15017 | 29848450 |
Hyperchloraemia | 13.26 | 10.36 | 11 | 89000 | 451 | 29863016 |
Urinary incontinence | 13.23 | 10.36 | 91 | 88920 | 16849 | 29846618 |
Gallbladder polyp | 13.20 | 10.36 | 9 | 89002 | 273 | 29863194 |
Blepharospasm | 13.19 | 10.36 | 15 | 88996 | 911 | 29862556 |
Hypomagnesaemia | 13.19 | 10.36 | 18 | 88993 | 16580 | 29846887 |
Lethargy | 13.07 | 10.36 | 177 | 88834 | 39342 | 29824125 |
Dementia with Lewy bodies | 13.01 | 10.36 | 12 | 88999 | 568 | 29862899 |
Learning disorder | 12.98 | 10.36 | 11 | 89000 | 465 | 29863002 |
Inappropriate affect | 12.98 | 10.36 | 12 | 88999 | 570 | 29862897 |
Bipolar II disorder | 12.90 | 10.36 | 4 | 89007 | 16 | 29863451 |
Psychiatric symptom | 12.88 | 10.36 | 30 | 88981 | 3349 | 29860118 |
Tuberculosis | 12.84 | 10.36 | 4 | 89007 | 8073 | 29855394 |
Drug level increased | 12.83 | 10.36 | 96 | 88915 | 18258 | 29845209 |
Libido decreased | 12.70 | 10.36 | 36 | 88975 | 4530 | 29858937 |
Bulbar palsy | 12.66 | 10.36 | 8 | 89003 | 213 | 29863254 |
Syncope | 12.59 | 10.36 | 177 | 88834 | 84726 | 29778741 |
Purpura | 12.53 | 10.36 | 7 | 89004 | 9960 | 29853507 |
Intelligence test abnormal | 12.52 | 10.36 | 4 | 89007 | 18 | 29863449 |
Areflexia | 12.47 | 10.36 | 26 | 88985 | 2693 | 29860774 |
Dysstasia | 12.46 | 10.36 | 63 | 88948 | 10442 | 29853025 |
Accidental poisoning | 12.43 | 10.36 | 11 | 89000 | 493 | 29862974 |
Pseudodementia | 12.39 | 10.36 | 3 | 89008 | 3 | 29863464 |
Hypothermia neonatal | 12.39 | 10.36 | 6 | 89005 | 93 | 29863374 |
Somatic symptom disorder | 12.36 | 10.36 | 11 | 89000 | 497 | 29862970 |
Infective pulmonary exacerbation of cystic fibrosis | 12.34 | 10.36 | 5 | 89006 | 8567 | 29854900 |
Dementia | 12.25 | 10.36 | 71 | 88940 | 12390 | 29851077 |
Hyperhidrosis | 12.21 | 10.36 | 273 | 88738 | 66817 | 29796650 |
Substance dependence | 12.14 | 10.36 | 10 | 89001 | 406 | 29863061 |
Stupor | 12.12 | 10.36 | 27 | 88984 | 2926 | 29860541 |
Autonomic nervous system imbalance | 12.11 | 10.36 | 24 | 88987 | 2397 | 29861070 |
Neurosis | 12.10 | 10.36 | 7 | 89004 | 158 | 29863309 |
Agitated depression | 12.02 | 10.36 | 8 | 89003 | 233 | 29863234 |
Glossopharyngeal nerve disorder | 12.02 | 10.36 | 4 | 89007 | 21 | 29863446 |
Squamous cell carcinoma of skin | 12 | 10.36 | 6 | 89005 | 9089 | 29854378 |
Neoplasm progression | 11.99 | 10.36 | 22 | 88989 | 18001 | 29845466 |
Haematuria traumatic | 11.95 | 10.36 | 7 | 89004 | 162 | 29863305 |
Muscle twitching | 11.94 | 10.36 | 52 | 88959 | 8103 | 29855364 |
Change in seizure presentation | 11.93 | 10.36 | 5 | 89006 | 54 | 29863413 |
Feeling drunk | 11.91 | 10.36 | 19 | 88992 | 1600 | 29861867 |
Post concussion syndrome | 11.85 | 10.36 | 5 | 89006 | 55 | 29863412 |
Senile dementia | 11.85 | 10.36 | 5 | 89006 | 55 | 29863412 |
Atrial flutter | 11.84 | 10.36 | 15 | 88996 | 14266 | 29849201 |
Jaundice | 11.77 | 10.36 | 53 | 88958 | 32433 | 29831034 |
Cerebral arteriosclerosis | 11.69 | 10.36 | 10 | 89001 | 428 | 29863039 |
Mumps | 11.68 | 10.36 | 6 | 89005 | 106 | 29863361 |
Clostridium difficile infection | 11.67 | 10.36 | 18 | 88993 | 15765 | 29847702 |
Helplessness | 11.61 | 10.36 | 5 | 89006 | 58 | 29863409 |
Cytopenia | 11.58 | 10.36 | 5 | 89006 | 8251 | 29855216 |
Rapid eye movement sleep behaviour disorder | 11.58 | 10.36 | 6 | 89005 | 108 | 29863359 |
Diet refusal | 11.58 | 10.36 | 9 | 89002 | 336 | 29863131 |
Social avoidant behaviour | 11.55 | 10.36 | 26 | 88985 | 2837 | 29860630 |
Obsessive thoughts | 11.53 | 10.36 | 12 | 88999 | 659 | 29862808 |
Pneumothorax | 11.47 | 10.36 | 19 | 88992 | 16174 | 29847293 |
Delirium | 11.46 | 10.36 | 177 | 88834 | 40454 | 29823013 |
Defect conduction intraventricular | 11.39 | 10.36 | 7 | 89004 | 177 | 29863290 |
Prostate cancer | 11.35 | 10.36 | 35 | 88976 | 23922 | 29839545 |
Therapy non-responder | 11.31 | 10.36 | 47 | 88964 | 29406 | 29834061 |
Dissociative identity disorder | 11.30 | 10.36 | 4 | 89007 | 26 | 29863441 |
Tumour lysis syndrome | 11.25 | 10.36 | 13 | 88998 | 12872 | 29850595 |
Oropharyngeal pain | 11.24 | 10.36 | 45 | 88966 | 28451 | 29835016 |
Communication disorder | 11.24 | 10.36 | 22 | 88989 | 2178 | 29861289 |
Chondrocalcinosis | 11.23 | 10.36 | 8 | 89003 | 261 | 29863206 |
Ventricular hypoplasia | 11.18 | 10.36 | 5 | 89006 | 64 | 29863403 |
Renal injury | 11.17 | 10.36 | 11 | 89000 | 11718 | 29851749 |
Pulmonary hypertension | 11.16 | 10.36 | 25 | 88986 | 19011 | 29844456 |
Brain oedema | 11.14 | 10.36 | 69 | 88942 | 12329 | 29851138 |
Therapeutic response unexpected | 10.99 | 10.36 | 54 | 88957 | 8849 | 29854618 |
Pseudomonas infection | 10.98 | 10.36 | 9 | 89002 | 10473 | 29852994 |
Adrenal insufficiency | 10.94 | 10.36 | 9 | 89002 | 10454 | 29853013 |
Rectal haemorrhage | 10.94 | 10.36 | 60 | 88951 | 34879 | 29828588 |
COVID-19 | 10.88 | 10.36 | 23 | 88988 | 17855 | 29845612 |
Irregular sleep phase | 10.84 | 10.36 | 5 | 89006 | 69 | 29863398 |
Blood osmolarity decreased | 10.83 | 10.36 | 11 | 89000 | 587 | 29862880 |
Fluid retention | 10.82 | 10.36 | 38 | 88973 | 24960 | 29838507 |
Cellulitis | 10.80 | 10.36 | 88 | 88923 | 46696 | 29816771 |
Disseminated intravascular coagulation | 10.78 | 10.36 | 32 | 88979 | 22139 | 29841328 |
Haemophagocytic lymphohistiocytosis | 10.77 | 10.36 | 8 | 89003 | 9783 | 29853684 |
Somatic delusion | 10.76 | 10.36 | 6 | 89005 | 126 | 29863341 |
Eye movement disorder | 10.76 | 10.36 | 31 | 88980 | 3937 | 29859530 |
Myositis | 10.76 | 10.36 | 9 | 89002 | 10368 | 29853099 |
Swelling face | 10.76 | 10.36 | 30 | 88981 | 21174 | 29842293 |
Malaise | 10.70 | 10.36 | 397 | 88614 | 166565 | 29696902 |
Diffuse large B-cell lymphoma | 10.61 | 10.36 | 5 | 89006 | 7836 | 29855631 |
Stoma site inflammation | 10.59 | 10.36 | 11 | 89000 | 603 | 29862864 |
Clonus | 10.54 | 10.36 | 23 | 88988 | 2458 | 29861009 |
Hallucinations, mixed | 10.53 | 10.36 | 23 | 88988 | 2460 | 29861007 |
Acute coronary syndrome | 10.50 | 10.36 | 15 | 88996 | 13558 | 29849909 |
Intestinal dilatation | 10.47 | 10.36 | 15 | 88996 | 1149 | 29862318 |
Anticonvulsant drug level decreased | 10.46 | 10.36 | 14 | 88997 | 1005 | 29862462 |
Peritonitis bacterial | 10.46 | 10.36 | 11 | 89000 | 11367 | 29852100 |
Fluid overload | 10.45 | 10.36 | 26 | 88985 | 19066 | 29844401 |
Ammonia increased | 10.42 | 10.36 | 32 | 88979 | 4209 | 29859258 |
Metamyelocyte count increased | 10.41 | 10.36 | 5 | 89006 | 76 | 29863391 |
Face oedema | 10.38 | 10.36 | 11 | 89000 | 11323 | 29852144 |
Source | Code | Description |
---|---|---|
ATC | N03AE01 | NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Benzodiazepine derivatives |
FDA CS | M0002356 | Benzodiazepines |
FDA EPC | N0000175694 | Benzodiazepine |
CHEBI has role | CHEBI:35474 | minor tranquilisers |
CHEBI has role | CHEBI:35623 | antiepileptic |
CHEBI has role | CHEBI:50268 | gaba modulators |
MeSH PA | D000927 | Anticonvulsants |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D018682 | GABA Agents |
MeSH PA | D018757 | GABA Modulators |
MeSH PA | D018377 | Neurotransmitter Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Myoclonic seizure | indication | 37356005 | |
Atonic seizure | indication | 42365007 | |
Absence seizure | indication | 79631006 | |
Lennox-Gastaut syndrome | indication | 230418006 | |
Panic disorder | indication | 371631005 | DOID:594 |
Akathisia | off-label use | 285145004 | |
Manic Bipolar Disorder Adjunct Treatment | off-label use | ||
Suicidal thoughts | contraindication | 6471006 | |
Alcohol intoxication | contraindication | 25702006 | |
Depressive disorder | contraindication | 35489007 | |
Hepatic failure | contraindication | 59927004 | |
Substance abuse | contraindication | 66214007 | |
Sleep apnea | contraindication | 73430006 | DOID:0050847 |
Decreased respiratory function | contraindication | 80954004 | |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Liver function tests abnormal | contraindication | 166603001 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Syncope | contraindication | 271594007 | |
Pregnancy, function | contraindication | 289908002 | |
At risk for aspiration | contraindication | 371736008 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Breastfeeding (mother) | contraindication | 413712001 | |
Chronic lung disease | contraindication | 413839001 | |
Central nervous system depression | contraindication | 418072004 | |
Porphyria | contraindication | 418470004 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 10.65 | acidic |
pKa2 | 1.65 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
GABA-A receptor alpha-1/beta-2/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 8.07 | WOMBAT-PK | CHEMBL | |||
GABA-A receptor; anion channel | Ion channel | Ki | 9.07 | CHEMBL | |||||
GABA-A receptor; anion channel | Ion channel | IC50 | 8.77 | CHEMBL | |||||
GABA-A receptor; anion channel | Ion channel | Ki | 9.07 | CHEMBL |
ID | Source |
---|---|
4017791 | VUID |
N0000146152 | NUI |
D00280 | KEGG_DRUG |
4017791 | VANDF |
C0009011 | UMLSCUI |
CHEBI:3756 | CHEBI |
CHEMBL452 | ChEMBL_ID |
DB01068 | DRUGBANK_ID |
D002998 | MESH_DESCRIPTOR_UI |
2802 | PUBCHEM_CID |
6963 | IUPHAR_LIGAND_ID |
2765 | INN_ID |
5PE9FDE8GB | UNII |
202585 | RXNORM |
1345 | MMSL |
377 | MMSL |
4477 | MMSL |
d00197 | MMSL |
001635 | NDDF |
387383007 | SNOMEDCT_US |
69708003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Klonopin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0004-0058 | TABLET | 1 mg | ORAL | NDA | 30 sections |
Klonopin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0004-0068 | TABLET | 0.50 mg | ORAL | NDA | 30 sections |
Klonopin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0004-0098 | TABLET | 2 mg | ORAL | NDA | 30 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0832 | TABLET | 0.50 mg | ORAL | ANDA | 20 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3212 | TABLET | 1 mg | ORAL | ANDA | 20 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3213 | TABLET | 2 mg | ORAL | ANDA | 20 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0063 | TABLET | 0.50 mg | ORAL | ANDA | 24 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0064 | TABLET | 1 mg | ORAL | ANDA | 24 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0065 | TABLET | 2 mg | ORAL | ANDA | 24 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-3003 | TABLET | 0.50 mg | ORAL | ANDA | 24 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-3004 | TABLET | 1 mg | ORAL | ANDA | 24 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-3005 | TABLET | 2 mg | ORAL | ANDA | 24 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0094 | TABLET, ORALLY DISINTEGRATING | 0.13 mg | ORAL | ANDA | 27 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0095 | TABLET, ORALLY DISINTEGRATING | 0.25 mg | ORAL | ANDA | 27 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0096 | TABLET, ORALLY DISINTEGRATING | 0.50 mg | ORAL | ANDA | 27 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0097 | TABLET, ORALLY DISINTEGRATING | 1 mg | ORAL | ANDA | 27 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0098 | TABLET, ORALLY DISINTEGRATING | 2 mg | ORAL | ANDA | 27 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8234 | TABLET | 0.50 mg | ORAL | ANDA | 26 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8235 | TABLET | 1 mg | ORAL | ANDA | 26 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8236 | TABLET | 2 mg | ORAL | ANDA | 26 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5567 | TABLET | 1 mg | ORAL | ANDA | 24 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5569 | TABLET | 2 mg | ORAL | ANDA | 24 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-8018 | TABLET | 0.50 mg | ORAL | ANDA | 24 sections |
CLONULLZEPAM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-058 | TABLET | 0.50 mg | ORAL | ANDA | 23 sections |
CLONULLZEPAM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-059 | TABLET | 1 mg | ORAL | ANDA | 23 sections |
CLONULLZEPAM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-481 | TABLET | 2 mg | ORAL | ANDA | 23 sections |
KLONOPIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-693 | TABLET | 0.50 mg | ORAL | NDA | 25 sections |
KLONOPIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-935 | TABLET | 1 mg | ORAL | NDA | 26 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-469 | TABLET | 0.50 mg | ORAL | ANDA | 18 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-470 | TABLET | 1 mg | ORAL | ANDA | 18 sections |