clonazepam Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diazepam derivatives	703	1622-61-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: clonazepam lonazep klonopin	An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses. Molecular weight: 315.71 Formula: C15H10ClN3O3 CLOGP: 2.38 LIPINSKI: 0 HAC: 6 HDO: 1 TPSA: 87.28 ALOGS: -4.47 ROTB: 2 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

clonazepam
lonazep
klonopin

An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.

Molecular weight: 315.71
Formula: C15H10ClN3O3
CLOGP: 2.38
LIPINSKI: 0
HAC: 6
HDO: 1
TPSA: 87.28
ALOGS: -4.47
ROTB: 2

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
8	mg	O
8	mg	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.10 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.42 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	98 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	2.90 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	0.88 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.15 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	38 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
June 4, 1975	FDA	ROCHE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	8425.24	37.47	1835	4690	19199	2332361
Toxicity to various agents	4405.57	37.47	1200	5325	31554	2320006
Cardio-respiratory arrest	1687.12	37.47	436	6089	8710	2342850
Respiratory arrest	1585.54	37.47	384	6141	5794	2345766
Cardiac arrest	1564.13	37.47	456	6069	14474	2337086
Drug abuse	1007.91	37.47	310	6215	11716	2339844
Overdose	991.89	37.47	346	6179	19561	2331999
Death	894.87	37.47	485	6040	80983	2270577
Intentional overdose	835.51	37.47	265	6260	11056	2340504
Suicide attempt	729.60	37.47	239	6286	11043	2340517
Poisoning	673.62	37.47	166	6359	2654	2348906
Somnolence	578.86	37.47	245	6280	23240	2328320
Drug ineffective	523.60	37.47	375	6150	101249	2250311
Intentional product misuse	474.68	37.47	166	6359	9323	2342237
Seizure	465.73	37.47	213	6312	24253	2327307
Anxiety	443.65	37.47	218	6307	29141	2322419
Hypotension	417.26	37.47	216	6309	32220	2319340
Depressed level of consciousness	360.84	37.47	128	6397	7476	2344084
Unresponsive to stimuli	317.12	37.47	104	6421	4772	2346788
Coma	257.73	37.47	105	6420	8951	2342609
Respiratory depression	250.73	37.47	72	6453	2098	2349462
Drug withdrawal syndrome	239.23	37.47	92	6433	6729	2344831
Insomnia	234.90	37.47	137	6388	25650	2325910
Depression	229.00	37.47	139	6386	27993	2323567
Bradycardia	224.78	37.47	98	6427	9883	2341677
Exposure via ingestion	221.64	37.47	53	6472	735	2350825
Suicidal ideation	221.23	37.47	100	6425	10987	2340573
Tremor	221.09	37.47	122	6403	20539	2331021
Agitation	205.77	37.47	95	6430	10956	2340604
Drug interaction	204.27	37.47	131	6394	29032	2322528
Sedation	203.62	37.47	68	6457	3294	2348266
Drug dependence	202.11	37.47	66	6459	2979	2348581
Electrocardiogram QT prolonged	199.92	37.47	84	6441	7730	2343830
Confusional state	197.29	37.47	120	6405	24224	2327336
Loss of consciousness	195.75	37.47	109	6416	18658	2332902
Neuroleptic malignant syndrome	191.96	37.47	58	6467	2022	2349538
Psychotic disorder	185.30	37.47	69	6456	4610	2346950
Fatigue	182.30	37.47	191	6334	84682	2266878
Lethargy	178.09	37.47	80	6445	8650	2342910
Mental status changes	176.96	37.47	70	6455	5512	2346048
Dizziness	159.00	37.47	150	6375	58515	2293045
Exposure during pregnancy	149.10	37.47	102	6423	25117	2326443
Hypoglycaemia	146.27	37.47	69	6456	8338	2343222
Withdrawal syndrome	146.10	37.47	53	6472	3284	2348276
Hyperhidrosis	145.68	37.47	84	6441	15338	2336222
Disturbance in attention	144.97	37.47	61	6464	5624	2345936
Condition aggravated	138.23	37.47	107	6418	31872	2319688
Feeling abnormal	136.12	37.47	94	6431	23487	2328073
Myocardial depression	132.18	37.47	23	6502	48	2351512
Encephalopathy	130.01	37.47	53	6472	4508	2347052
Hallucination	129.95	37.47	63	6462	8085	2343475
Decorticate posture	127.88	37.47	21	6504	25	2351535
Aggression	124.17	37.47	52	6473	4734	2346826
Serotonin syndrome	121.34	37.47	47	6478	3493	2348067
Sopor	115.83	37.47	47	6478	3948	2347612
Fall	113.44	37.47	113	6412	46986	2304574
Poisoning deliberate	113.26	37.47	34	6491	1157	2350403
Disorientation	112.97	37.47	53	6472	6319	2345241
Balance disorder	110.82	37.47	60	6465	9687	2341873
Medication error	108.71	37.47	51	6474	6080	2345480
Memory impairment	107.84	37.47	65	6460	12858	2338702
Myocardial stunning	107.64	37.47	18	6507	26	2351534
Dysarthria	107.37	37.47	51	6474	6251	2345309
Coma scale abnormal	107.35	37.47	30	6495	788	2350772
Maternal exposure during pregnancy	106.90	37.47	68	6457	14795	2336765
Product complaint	106.75	37.47	46	6479	4492	2347068
Drug hypersensitivity	105.17	37.47	108	6417	46535	2305025
Status epilepticus	103.41	37.47	38	6487	2440	2349120
Nausea	101.60	37.47	165	6360	112024	2239536
Therapeutic response unexpected	100.33	37.47	42	6483	3817	2347743
Malaise	99.60	37.47	114	6411	55471	2296089
Headache	98.36	37.47	136	6389	80043	2271517
Irritability	97.38	37.47	48	6477	6379	2345181
Foetal exposure during pregnancy	97.17	37.47	45	6480	5207	2346353
Weight increased	96.97	37.47	75	6450	22262	2329298
Vomiting	94.69	37.47	126	6399	71476	2280084
Aspiration	88.76	37.47	30	6495	1504	2350056
Schizophrenia	88.28	37.47	29	6496	1330	2350230
Sleep disorder	88.12	37.47	45	6480	6444	2345116
Heart rate increased	87.87	37.47	54	6471	11051	2340509
Panic attack	86.20	37.47	38	6487	3918	2347642
Dystonia	85.51	37.47	32	6493	2162	2349398
Asthenia	85.29	37.47	97	6428	46829	2304731
Tachycardia	84.36	37.47	61	6464	16348	2335212
Muscle rigidity	83.56	37.47	30	6495	1801	2349759
Miosis	83.07	37.47	27	6498	1197	2350363
Ventricular hypokinesia	82.48	37.47	23	6502	599	2350961
Cardiogenic shock	81.56	37.47	32	6493	2459	2349101
Ataxia	81.54	37.47	32	6493	2460	2349100
Restlessness	81.00	37.47	38	6487	4525	2347035
Product substitution issue	80.20	37.47	39	6486	5030	2346530
Myoclonus	78.15	37.47	31	6494	2452	2349108
Electrocardiogram QRS complex prolonged	77.60	37.47	25	6500	1077	2350483
Pulmonary oedema	77.25	37.47	43	6482	7320	2344240
Speech disorder	76.83	37.47	41	6484	6423	2345137
Vision blurred	76.47	37.47	55	6470	14613	2336947
Nervousness	76.35	37.47	38	6487	5151	2346409
Acute respiratory distress syndrome	76.20	37.47	33	6492	3259	2348301
Catatonia	75.38	37.47	23	6502	827	2350733
Hypothermia	75.30	37.47	29	6496	2119	2349441
Pneumonia aspiration	75.30	37.47	34	6491	3708	2347852
Intentional self-injury	75.21	37.47	35	6490	4092	2347468
Mydriasis	70.87	37.47	28	6497	2191	2349369
Cyanosis	70.70	37.47	31	6494	3154	2348406
Urinary bladder rupture	70.15	37.47	13	6512	44	2351516
Abortion spontaneous	69.13	37.47	50	6475	13395	2338165
Respiratory failure	68.86	37.47	50	6475	13478	2338082
Constipation	67.49	37.47	60	6465	21569	2329991
Gait disturbance	67.31	37.47	61	6464	22484	2329076
Amnesia	67.05	37.47	39	6486	7214	2344346
Generalised tonic-clonic seizure	66.45	37.47	35	6490	5337	2346223
Cognitive disorder	66.40	37.47	35	6490	5346	2346214
Blood pressure decreased	65.72	37.47	42	6483	9194	2342366
Syncope	65.33	37.47	53	6472	16822	2334738
Accidental overdose	64.15	37.47	31	6494	3941	2347619
Aphasia	63.50	37.47	33	6492	4895	2346665
Electrocardiogram QRS complex shortened	62.99	37.47	13	6512	86	2351474
Rhabdomyolysis	61.84	37.47	36	6489	6668	2344892
Paranoia	61.78	37.47	25	6500	2082	2349478
Mania	61.55	37.47	26	6499	2414	2349146
Drug screen positive	61.23	37.47	20	6505	900	2350660
Purpura senile	59.57	37.47	10	6515	15	2351545
Delirium	58.90	37.47	32	6493	5191	2346369
Pregnancy	58.67	37.47	37	6488	7912	2343648
Drug screen negative	58.32	37.47	12	6513	78	2351482
Dysphagia	57.71	37.47	44	6481	12761	2338799
Respiratory rate decreased	57.22	37.47	17	6508	557	2351003
Incontinence	55.90	37.47	21	6504	1433	2350127
Hepatitis	55.74	37.47	33	6492	6304	2345256
Mental disorder	55.00	37.47	28	6497	3979	2347581
Arrhythmia	54.62	37.47	32	6493	5996	2345564
Treatment noncompliance	54.46	37.47	31	6494	5503	2346057
Alanine aminotransferase increased	54.15	37.47	44	6481	13988	2337572
Developmental glaucoma	52.66	37.47	9	6516	16	2351544
Delusion	52.07	37.47	22	6503	2043	2349517
Intellectual disability	51.98	37.47	12	6513	141	2351419
Anger	51.13	37.47	23	6502	2484	2349076
Hypoxia	51.07	37.47	31	6494	6196	2345364
Pneumonia	50.60	37.47	77	6448	49219	2302341
Body temperature decreased	50.47	37.47	19	6506	1304	2350256
Weight decreased	50.36	37.47	58	6467	28313	2323247
Hypersomnia	49.19	37.47	22	6503	2344	2349216
Hypotonia	48.91	37.47	20	6505	1710	2349850
Palpitations	48.06	37.47	44	6481	16412	2335148
Off label use	47.99	37.47	94	6431	73504	2278056
Tarsal tunnel syndrome	47.79	37.47	9	6516	34	2351526
Dyskinesia	47.59	37.47	27	6498	4762	2346798
Soft tissue haemorrhage	47.58	37.47	9	6516	35	2351525
Pupil fixed	47.56	37.47	14	6511	444	2351116
Product use in unapproved indication	47.22	37.47	37	6488	11163	2340397
Dehydration	47.20	37.47	50	6475	22245	2329315
Paradoxical drug reaction	47.11	37.47	14	6511	459	2351101
Fear	47.08	37.47	22	6503	2594	2348966
Muscle spasms	46.79	37.47	49	6476	21517	2330043
Hepatic necrosis	46.22	37.47	17	6508	1093	2350467
Akathisia	46.13	37.47	19	6506	1655	2349905
Blood creatine phosphokinase increased	45.83	37.47	27	6498	5109	2346451
Urinary retention	45.65	37.47	24	6501	3643	2347917
Nightmare	45.47	37.47	24	6501	3673	2347887
Aspartate aminotransferase increased	45.42	37.47	38	6487	12574	2338986
Multiple organ dysfunction syndrome	45.26	37.47	31	6494	7610	2343950
Substance abuse	45.06	37.47	14	6511	535	2351025
Blood pressure increased	44.96	37.47	43	6482	16943	2334617
Blood sodium decreased	43.53	37.47	22	6503	3078	2348482
Electroencephalogram abnormal	43.26	37.47	15	6510	812	2350748
Drug withdrawal syndrome neonatal	43.24	37.47	13	6512	444	2351116
Coordination abnormal	42.98	37.47	19	6506	1969	2349591
Decreased appetite	42.97	37.47	54	6471	28837	2322723
Hyperreflexia	42.00	37.47	15	6510	886	2350674
Emotional disorder	41.33	37.47	19	6506	2158	2349402
No adverse event	41.30	37.47	32	6493	9496	2342064
Parkinsonism	41.19	37.47	17	6508	1488	2350072
Drug resistance	40.92	37.47	20	6505	2604	2348956
Paraesthesia	40.61	37.47	46	6479	22042	2329518
Hypoaesthesia	40.43	37.47	44	6481	20171	2331389
Antipsychotic drug level increased	40.43	37.47	13	6512	556	2351004
Toxic leukoencephalopathy	40.04	37.47	9	6516	93	2351467
Loss of personal independence in daily activities	39.88	37.47	25	6500	5286	2346274
Therapeutic product effect decreased	39.87	37.47	33	6492	10756	2340804
Hypomania	39.76	37.47	14	6511	793	2350767
Metabolic acidosis	39.52	37.47	26	6499	5972	2345588
Dyspnoea	39.08	37.47	90	6435	78643	2272917
Crying	38.93	37.47	23	6502	4373	2347187
Skin abrasion	38.75	37.47	15	6510	1110	2350450
Hypophagia	38.26	37.47	22	6503	3978	2347582
Epileptic encephalopathy	38.16	37.47	7	6518	22	2351538
Incoherent	38.04	37.47	14	6511	901	2350659
Pyrexia	37.92	37.47	71	6454	53637	2297923
Depressed mood	37.86	37.47	24	6501	5174	2346386
Alcohol poisoning	37.85	37.47	11	6514	333	2351227
Epilepsy	37.79	37.47	23	6502	4616	2346944
Panic disorder	37.67	37.47	12	6513	498	2351062
Drug withdrawal convulsions	37.54	37.47	11	6514	343	2351217

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	3128.06	43.16	812	3651	15500	1726818
Toxicity to various agents	2832.84	43.16	851	3612	28290	1714028
Drug abuse	1905.20	43.16	533	3930	13156	1729162
Respiratory arrest	1055.13	43.16	281	4182	5558	1736760
Cardio-respiratory arrest	1021.75	43.16	303	4160	8990	1733328
Cardiac arrest	931.07	43.16	321	4142	15609	1726709
Overdose	646.98	43.16	249	4214	16452	1725866
Death	551.41	43.16	381	4082	87062	1655256
Intentional product misuse	469.20	43.16	159	4304	7199	1735119
Drug ineffective	390.13	43.16	274	4189	63527	1678791
Poisoning	349.33	43.16	99	4364	2433	1739885
Intentional overdose	322.99	43.16	122	4341	7548	1734770
Seizure	315.12	43.16	160	4303	20281	1722037
Suicide attempt	309.30	43.16	117	4346	7264	1735054
Coma	303.87	43.16	115	4348	7147	1735171
Sedation	303.20	43.16	95	4368	3322	1738996
Somnolence	293.26	43.16	143	4320	16596	1725722
Drug interaction	291.98	43.16	169	4294	27789	1714529
Anxiety	266.93	43.16	131	4332	15396	1726922
Respiratory depression	248.36	43.16	74	4389	2173	1740145
Depressed level of consciousness	242.12	43.16	95	4368	6497	1735821
Unresponsive to stimuli	225.34	43.16	82	4381	4547	1737771
Agitation	198.14	43.16	96	4367	10930	1731388
Depression	190.20	43.16	107	4356	16562	1725756
Aggression	177.62	43.16	81	4382	8034	1734284
Hypotension	169.54	43.16	123	4340	29531	1712787
Confusional state	161.09	43.16	105	4358	21173	1721145
Neuroleptic malignant syndrome	157.71	43.16	57	4406	3091	1739227
Substance abuse	155.38	43.16	43	4420	960	1741358
Serotonin syndrome	152.94	43.16	54	4409	2734	1739584
Insomnia	149.93	43.16	91	4372	16185	1726133
Ataxia	142.23	43.16	49	4414	2304	1740014
Loss of consciousness	136.54	43.16	83	4380	14792	1727526
Status epilepticus	133.01	43.16	45	4418	2001	1740317
Fall	126.82	43.16	100	4363	27114	1715204
Abnormal behaviour	122.20	43.16	58	4405	6284	1736034
Accidental overdose	111.73	43.16	48	4415	4116	1738202
Drug dependence	108.24	43.16	44	4419	3283	1739035
Encephalopathy	105.42	43.16	47	4416	4405	1737913
Parkinsonism	104.51	43.16	34	4429	1335	1740983
Speech disorder	104.46	43.16	47	4416	4501	1737817
Muscle rigidity	102.10	43.16	36	4427	1812	1740506
Tachycardia	99.50	43.16	64	4399	12564	1729754
Pulmonary oedema	99.36	43.16	51	4412	6535	1735783
Drug withdrawal syndrome	98.35	43.16	45	4418	4480	1737838
Dysarthria	94.91	43.16	46	4417	5213	1737105
Condition aggravated	94.72	43.16	76	4387	21074	1721244
Gait disturbance	94.39	43.16	62	4401	12608	1729710
Medication error	93.24	43.16	44	4419	4699	1737619
Disinhibition	93.20	43.16	23	4440	321	1741997
Mental status changes	91.51	43.16	47	4416	6028	1736290
Exposure via ingestion	90.96	43.16	26	4437	654	1741664
Electrocardiogram QT prolonged	89.64	43.16	45	4418	5500	1736818
Intentional self-injury	89.16	43.16	36	4427	2637	1739681
Brain oedema	88.80	43.16	34	4429	2162	1740156
Acute pulmonary oedema	87.95	43.16	29	4434	1188	1741130
Tremor	87.59	43.16	60	4403	13071	1729247
Disturbance in attention	85.44	43.16	40	4423	4194	1738124
Bradycardia	84.47	43.16	54	4409	10480	1731838
Suicidal ideation	81.83	43.16	49	4414	8469	1733849
Generalised tonic-clonic seizure	80.95	43.16	38	4425	4008	1738310
Hyperhidrosis	80.78	43.16	56	4407	12432	1729886
Epilepsy	78.64	43.16	37	4426	3922	1738396
Dystonia	77.21	43.16	30	4433	1984	1740334
Acute respiratory distress syndrome	76.16	43.16	35	4428	3516	1738802
Dyskinesia	73.73	43.16	35	4428	3784	1738534
Poisoning deliberate	68.69	43.16	22	4441	820	1741498
Asterixis	67.80	43.16	17	4446	254	1742064
Salivary hypersecretion	67.64	43.16	25	4438	1440	1740878
Myoclonus	66.65	43.16	28	4435	2267	1740051
Psychotic disorder	64.44	43.16	35	4428	5021	1737297
Respiratory failure	60.38	43.16	50	4413	14455	1727863
Blood creatine phosphokinase increased	60.27	43.16	41	4422	8815	1733503
Miosis	60.16	43.16	23	4440	1455	1740863
Drug screen positive	59.93	43.16	21	4442	1036	1741282
Hyponatraemia	59.67	43.16	41	4422	8959	1733359
Off label use	59.56	43.16	78	4385	38493	1703825
Dysmetria	59.36	43.16	12	4451	61	1742257
Personality disorder	58.86	43.16	15	4448	240	1742078
Hypotonia	58.81	43.16	23	4440	1547	1740771
Illness anxiety disorder	58.53	43.16	11	4452	35	1742283
Treatment noncompliance	58.06	43.16	33	4430	5168	1737150
Foetal exposure during pregnancy	56.97	43.16	35	4428	6324	1735994
Withdrawal syndrome	56.85	43.16	25	4438	2263	1740055
Multiple-drug resistance	55.96	43.16	15	4448	295	1742023
Catatonia	55.66	43.16	19	4444	866	1741452
Thinking abnormal	55.50	43.16	21	4442	1291	1741027
Memory impairment	55.47	43.16	35	4428	6628	1735690
Drug level increased	55.28	43.16	26	4437	2751	1739567
Electrocardiogram QRS complex prolonged	54.11	43.16	18	4445	757	1741561
Postictal paralysis	53.40	43.16	10	4453	31	1742287
Restlessness	52.53	43.16	29	4434	4292	1738026
Panic attack	51.79	43.16	22	4441	1830	1740488
Sleep apnoea syndrome	51.78	43.16	23	4440	2131	1740187
Sinus tachycardia	51.30	43.16	24	4439	2508	1739810
Rhabdomyolysis	49.86	43.16	40	4423	11050	1731268
Intentional product use issue	49.67	43.16	24	4439	2695	1739623
Delirium	49.43	43.16	32	4431	6330	1735988
Mental disorder	48.65	43.16	24	4439	2819	1739499
Lethargy	48.25	43.16	33	4430	7151	1735167
Product substitution issue	48.22	43.16	25	4438	3261	1739057
Respiratory acidosis	48.12	43.16	16	4447	672	1741646
Fatigue	47.21	43.16	81	4382	50700	1691618
Pneumonia aspiration	47.20	43.16	29	4434	5237	1737081
Cognitive disorder	47.05	43.16	27	4436	4303	1738015
Hyperthermia	46.99	43.16	20	4443	1671	1740647
Disorientation	46.19	43.16	29	4434	5440	1736878
Drooling	46.01	43.16	16	4447	771	1741547
Product complaint	45.55	43.16	22	4441	2468	1739850
Feeling of despair	45.30	43.16	12	4451	225	1742093
Apathy	45.08	43.16	18	4445	1278	1741040
Depression suicidal	44.90	43.16	12	4451	233	1742085
Altered state of consciousness	43.97	43.16	24	4439	3473	1738845

Pharmacologic Action:

Source	Code	Description
ATC	N03AE01	NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Benzodiazepine derivatives
CHEBI has role	CHEBI:35623	anticonvulsant
CHEBI has role	CHEBI:50268	GABA modulator
CHEBI has role	CHEBI:35474	anxiolytic drug
MeSH PA	D000927	Anticonvulsants
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D018682	GABA Agents
MeSH PA	D018757	GABA Modulators
MeSH PA	D018377	Neurotransmitter Agents
FDA EPC	N0000175694	Benzodiazepine
FDA CS	M0002356	Benzodiazepines

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Myoclonic seizure	indication	37356005
Atonic seizure	indication	42365007
Absence seizure	indication	79631006
Lennox-Gastaut syndrome	indication	230418006
Panic disorder	indication	371631005	DOID:594
Akathisia	off-label use	285145004
Manic Bipolar Disorder Adjunct Treatment	off-label use
Suicidal thoughts	contraindication	6471006
Alcohol intoxication	contraindication	25702006
Depressive disorder	contraindication	35489007
Hepatic failure	contraindication	59927004
Substance abuse	contraindication	66214007
Sleep apnea	contraindication	73430006	DOID:0050847
Decreased respiratory function	contraindication	80954004
Open-angle glaucoma	contraindication	84494001	DOID:1067
Kidney disease	contraindication	90708001	DOID:557
Liver function tests abnormal	contraindication	166603001
Disease of liver	contraindication	235856003	DOID:409
Syncope	contraindication	271594007
Pregnancy, function	contraindication	289908002
At risk for aspiration	contraindication	371736008
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Breastfeeding (mother)	contraindication	413712001
Chronic lung disease	contraindication	413839001
Central nervous system depression	contraindication	418072004
Porphyria	contraindication	418470004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.65	acidic
pKa2	1.65	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
GABA-A receptor alpha-1/beta-2/gamma-2	Ion channel	P14867 P18507 P47870	GBRA1_HUMAN GBRB2_HUMAN GBRG2_HUMAN	POSITIVE ALLOSTERIC MODULATOR	Ki	8.07	WOMBAT-PK	CHEMBL
GABA-A receptor; anion channel	Ion channel	O00591 O14764 P14867 P18505 P18507 P28472 P31644 P34903 P47869 P47870 P48169 P78334 Q16445 Q8N1C3 Q99928 Q9UN88	GBRA1_HUMAN GBRA2_HUMAN GBRA3_HUMAN GBRA4_HUMAN GBRA5_HUMAN GBRA6_HUMAN GBRB1_HUMAN GBRB2_HUMAN GBRB3_HUMAN GBRD_HUMAN GBRE_HUMAN GBRG1_HUMAN GBRG2_HUMAN GBRG3_HUMAN GBRP_HUMAN GBRT_HUMAN		Ki	9.07	CHEMBL
GABA-A receptor; anion channel	Ion channel		GBRA1_RAT GBRA2_RAT GBRA3_RAT GBRA4_RAT GBRA5_RAT GBRA6_RAT GBRB1_RAT GBRB2_RAT GBRB3_RAT GBRD_RAT GBRE_RAT GBRG1_RAT GBRG2_RAT GBRG3_RAT GBRP_RAT Q91ZM7_RAT		IC50	8.77	CHEMBL
GABA-A receptor; anion channel	Ion channel		GBRA1_BOVIN GBRA2_BOVIN GBRA3_BOVIN GBRA4_BOVIN GBRB1_BOVIN GBRG2_BOVIN		Ki	9.07	CHEMBL

External reference:

ID	Source
D002998	MESH_DESCRIPTOR_UI
4017791	VUID
N0000146152	NUI
C0009011	UMLSCUI
D00280	KEGG_DRUG
5PE9FDE8GB	UNII
2765	INN_ID
69708003	SNOMEDCT_US
4017791	VANDF
001635	NDDF
2598	RXNORM
377	MMSL
d00197	MMSL
387383007	SNOMEDCT_US
4477	MMSL
CHEMBL452	ChEMBL_ID
DB01068	DRUGBANK_ID
CHEBI:3756	CHEBI
6963	IUPHAR_LIGAND_ID
2802	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Klonopin	HUMAN PRESCRIPTION DRUG LABEL	1	0004-0058	TABLET	1 mg	ORAL	NDA	15 sections
Klonopin	HUMAN PRESCRIPTION DRUG LABEL	1	0004-0068	TABLET	0.50 mg	ORAL	NDA	15 sections
Klonopin	HUMAN PRESCRIPTION DRUG LABEL	1	0004-0098	TABLET	2 mg	ORAL	NDA	15 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0832	TABLET	0.50 mg	ORAL	ANDA	14 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3212	TABLET	1 mg	ORAL	ANDA	14 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3213	TABLET	2 mg	ORAL	ANDA	14 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0063	TABLET	0.50 mg	ORAL	ANDA	14 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0064	TABLET	1 mg	ORAL	ANDA	14 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0065	TABLET	2 mg	ORAL	ANDA	14 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-3003	TABLET	0.50 mg	ORAL	ANDA	15 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-3004	TABLET	1 mg	ORAL	ANDA	15 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-3005	TABLET	2 mg	ORAL	ANDA	15 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1910	TABLET	0.50 mg	ORAL	ANDA	14 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1912	TABLET	1 mg	ORAL	ANDA	14 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1914	TABLET	2 mg	ORAL	ANDA	14 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0555-0094	TABLET, ORALLY DISINTEGRATING	0.13 mg	ORAL	ANDA	15 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0555-0095	TABLET, ORALLY DISINTEGRATING	0.25 mg	ORAL	ANDA	15 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0555-0096	TABLET, ORALLY DISINTEGRATING	0.50 mg	ORAL	ANDA	15 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0555-0097	TABLET, ORALLY DISINTEGRATING	1 mg	ORAL	ANDA	15 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0555-0098	TABLET, ORALLY DISINTEGRATING	2 mg	ORAL	ANDA	15 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7796	TABLET	0.50 mg	ORAL	ANDA	14 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8001	TABLET	0.50 mg	ORAL	ANDA	13 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8002	TABLET	1 mg	ORAL	ANDA	13 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8048	TABLET	2 mg	ORAL	ANDA	13 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8227	TABLET	0.50 mg	ORAL	ANDA	15 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8234	TABLET	0.50 mg	ORAL	ANDA	13 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8235	TABLET	1 mg	ORAL	ANDA	13 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8236	TABLET	2 mg	ORAL	ANDA	13 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0781-5567	TABLET	1 mg	ORAL	ANDA	14 sections
Clonazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0781-5569	TABLET	2 mg	ORAL	ANDA	14 sections