Stem definition | Drug id | CAS RN |
---|---|---|
diazepam derivatives | 703 | 1622-61-3 |
Dose | Unit | Route |
---|---|---|
8 | mg | O |
8 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.10 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.42 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 98 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 2.90 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.88 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.15 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 38 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
June 4, 1975 | FDA | ROCHE |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 8425.24 | 37.47 | 1835 | 4690 | 19199 | 2332361 |
Toxicity to various agents | 4405.57 | 37.47 | 1200 | 5325 | 31554 | 2320006 |
Cardio-respiratory arrest | 1687.12 | 37.47 | 436 | 6089 | 8710 | 2342850 |
Respiratory arrest | 1585.54 | 37.47 | 384 | 6141 | 5794 | 2345766 |
Cardiac arrest | 1564.13 | 37.47 | 456 | 6069 | 14474 | 2337086 |
Drug abuse | 1007.91 | 37.47 | 310 | 6215 | 11716 | 2339844 |
Overdose | 991.89 | 37.47 | 346 | 6179 | 19561 | 2331999 |
Death | 894.87 | 37.47 | 485 | 6040 | 80983 | 2270577 |
Intentional overdose | 835.51 | 37.47 | 265 | 6260 | 11056 | 2340504 |
Suicide attempt | 729.60 | 37.47 | 239 | 6286 | 11043 | 2340517 |
Poisoning | 673.62 | 37.47 | 166 | 6359 | 2654 | 2348906 |
Somnolence | 578.86 | 37.47 | 245 | 6280 | 23240 | 2328320 |
Drug ineffective | 523.60 | 37.47 | 375 | 6150 | 101249 | 2250311 |
Intentional product misuse | 474.68 | 37.47 | 166 | 6359 | 9323 | 2342237 |
Seizure | 465.73 | 37.47 | 213 | 6312 | 24253 | 2327307 |
Anxiety | 443.65 | 37.47 | 218 | 6307 | 29141 | 2322419 |
Hypotension | 417.26 | 37.47 | 216 | 6309 | 32220 | 2319340 |
Depressed level of consciousness | 360.84 | 37.47 | 128 | 6397 | 7476 | 2344084 |
Unresponsive to stimuli | 317.12 | 37.47 | 104 | 6421 | 4772 | 2346788 |
Coma | 257.73 | 37.47 | 105 | 6420 | 8951 | 2342609 |
Respiratory depression | 250.73 | 37.47 | 72 | 6453 | 2098 | 2349462 |
Drug withdrawal syndrome | 239.23 | 37.47 | 92 | 6433 | 6729 | 2344831 |
Insomnia | 234.90 | 37.47 | 137 | 6388 | 25650 | 2325910 |
Depression | 229.00 | 37.47 | 139 | 6386 | 27993 | 2323567 |
Bradycardia | 224.78 | 37.47 | 98 | 6427 | 9883 | 2341677 |
Exposure via ingestion | 221.64 | 37.47 | 53 | 6472 | 735 | 2350825 |
Suicidal ideation | 221.23 | 37.47 | 100 | 6425 | 10987 | 2340573 |
Tremor | 221.09 | 37.47 | 122 | 6403 | 20539 | 2331021 |
Agitation | 205.77 | 37.47 | 95 | 6430 | 10956 | 2340604 |
Drug interaction | 204.27 | 37.47 | 131 | 6394 | 29032 | 2322528 |
Sedation | 203.62 | 37.47 | 68 | 6457 | 3294 | 2348266 |
Drug dependence | 202.11 | 37.47 | 66 | 6459 | 2979 | 2348581 |
Electrocardiogram QT prolonged | 199.92 | 37.47 | 84 | 6441 | 7730 | 2343830 |
Confusional state | 197.29 | 37.47 | 120 | 6405 | 24224 | 2327336 |
Loss of consciousness | 195.75 | 37.47 | 109 | 6416 | 18658 | 2332902 |
Neuroleptic malignant syndrome | 191.96 | 37.47 | 58 | 6467 | 2022 | 2349538 |
Psychotic disorder | 185.30 | 37.47 | 69 | 6456 | 4610 | 2346950 |
Fatigue | 182.30 | 37.47 | 191 | 6334 | 84682 | 2266878 |
Lethargy | 178.09 | 37.47 | 80 | 6445 | 8650 | 2342910 |
Mental status changes | 176.96 | 37.47 | 70 | 6455 | 5512 | 2346048 |
Dizziness | 159.00 | 37.47 | 150 | 6375 | 58515 | 2293045 |
Exposure during pregnancy | 149.10 | 37.47 | 102 | 6423 | 25117 | 2326443 |
Hypoglycaemia | 146.27 | 37.47 | 69 | 6456 | 8338 | 2343222 |
Withdrawal syndrome | 146.10 | 37.47 | 53 | 6472 | 3284 | 2348276 |
Hyperhidrosis | 145.68 | 37.47 | 84 | 6441 | 15338 | 2336222 |
Disturbance in attention | 144.97 | 37.47 | 61 | 6464 | 5624 | 2345936 |
Condition aggravated | 138.23 | 37.47 | 107 | 6418 | 31872 | 2319688 |
Feeling abnormal | 136.12 | 37.47 | 94 | 6431 | 23487 | 2328073 |
Myocardial depression | 132.18 | 37.47 | 23 | 6502 | 48 | 2351512 |
Encephalopathy | 130.01 | 37.47 | 53 | 6472 | 4508 | 2347052 |
Hallucination | 129.95 | 37.47 | 63 | 6462 | 8085 | 2343475 |
Decorticate posture | 127.88 | 37.47 | 21 | 6504 | 25 | 2351535 |
Aggression | 124.17 | 37.47 | 52 | 6473 | 4734 | 2346826 |
Serotonin syndrome | 121.34 | 37.47 | 47 | 6478 | 3493 | 2348067 |
Sopor | 115.83 | 37.47 | 47 | 6478 | 3948 | 2347612 |
Fall | 113.44 | 37.47 | 113 | 6412 | 46986 | 2304574 |
Poisoning deliberate | 113.26 | 37.47 | 34 | 6491 | 1157 | 2350403 |
Disorientation | 112.97 | 37.47 | 53 | 6472 | 6319 | 2345241 |
Balance disorder | 110.82 | 37.47 | 60 | 6465 | 9687 | 2341873 |
Medication error | 108.71 | 37.47 | 51 | 6474 | 6080 | 2345480 |
Memory impairment | 107.84 | 37.47 | 65 | 6460 | 12858 | 2338702 |
Myocardial stunning | 107.64 | 37.47 | 18 | 6507 | 26 | 2351534 |
Dysarthria | 107.37 | 37.47 | 51 | 6474 | 6251 | 2345309 |
Coma scale abnormal | 107.35 | 37.47 | 30 | 6495 | 788 | 2350772 |
Maternal exposure during pregnancy | 106.90 | 37.47 | 68 | 6457 | 14795 | 2336765 |
Product complaint | 106.75 | 37.47 | 46 | 6479 | 4492 | 2347068 |
Drug hypersensitivity | 105.17 | 37.47 | 108 | 6417 | 46535 | 2305025 |
Status epilepticus | 103.41 | 37.47 | 38 | 6487 | 2440 | 2349120 |
Nausea | 101.60 | 37.47 | 165 | 6360 | 112024 | 2239536 |
Therapeutic response unexpected | 100.33 | 37.47 | 42 | 6483 | 3817 | 2347743 |
Malaise | 99.60 | 37.47 | 114 | 6411 | 55471 | 2296089 |
Headache | 98.36 | 37.47 | 136 | 6389 | 80043 | 2271517 |
Irritability | 97.38 | 37.47 | 48 | 6477 | 6379 | 2345181 |
Foetal exposure during pregnancy | 97.17 | 37.47 | 45 | 6480 | 5207 | 2346353 |
Weight increased | 96.97 | 37.47 | 75 | 6450 | 22262 | 2329298 |
Vomiting | 94.69 | 37.47 | 126 | 6399 | 71476 | 2280084 |
Aspiration | 88.76 | 37.47 | 30 | 6495 | 1504 | 2350056 |
Schizophrenia | 88.28 | 37.47 | 29 | 6496 | 1330 | 2350230 |
Sleep disorder | 88.12 | 37.47 | 45 | 6480 | 6444 | 2345116 |
Heart rate increased | 87.87 | 37.47 | 54 | 6471 | 11051 | 2340509 |
Panic attack | 86.20 | 37.47 | 38 | 6487 | 3918 | 2347642 |
Dystonia | 85.51 | 37.47 | 32 | 6493 | 2162 | 2349398 |
Asthenia | 85.29 | 37.47 | 97 | 6428 | 46829 | 2304731 |
Tachycardia | 84.36 | 37.47 | 61 | 6464 | 16348 | 2335212 |
Muscle rigidity | 83.56 | 37.47 | 30 | 6495 | 1801 | 2349759 |
Miosis | 83.07 | 37.47 | 27 | 6498 | 1197 | 2350363 |
Ventricular hypokinesia | 82.48 | 37.47 | 23 | 6502 | 599 | 2350961 |
Cardiogenic shock | 81.56 | 37.47 | 32 | 6493 | 2459 | 2349101 |
Ataxia | 81.54 | 37.47 | 32 | 6493 | 2460 | 2349100 |
Restlessness | 81.00 | 37.47 | 38 | 6487 | 4525 | 2347035 |
Product substitution issue | 80.20 | 37.47 | 39 | 6486 | 5030 | 2346530 |
Myoclonus | 78.15 | 37.47 | 31 | 6494 | 2452 | 2349108 |
Electrocardiogram QRS complex prolonged | 77.60 | 37.47 | 25 | 6500 | 1077 | 2350483 |
Pulmonary oedema | 77.25 | 37.47 | 43 | 6482 | 7320 | 2344240 |
Speech disorder | 76.83 | 37.47 | 41 | 6484 | 6423 | 2345137 |
Vision blurred | 76.47 | 37.47 | 55 | 6470 | 14613 | 2336947 |
Nervousness | 76.35 | 37.47 | 38 | 6487 | 5151 | 2346409 |
Acute respiratory distress syndrome | 76.20 | 37.47 | 33 | 6492 | 3259 | 2348301 |
Catatonia | 75.38 | 37.47 | 23 | 6502 | 827 | 2350733 |
Hypothermia | 75.30 | 37.47 | 29 | 6496 | 2119 | 2349441 |
Pneumonia aspiration | 75.30 | 37.47 | 34 | 6491 | 3708 | 2347852 |
Intentional self-injury | 75.21 | 37.47 | 35 | 6490 | 4092 | 2347468 |
Mydriasis | 70.87 | 37.47 | 28 | 6497 | 2191 | 2349369 |
Cyanosis | 70.70 | 37.47 | 31 | 6494 | 3154 | 2348406 |
Urinary bladder rupture | 70.15 | 37.47 | 13 | 6512 | 44 | 2351516 |
Abortion spontaneous | 69.13 | 37.47 | 50 | 6475 | 13395 | 2338165 |
Respiratory failure | 68.86 | 37.47 | 50 | 6475 | 13478 | 2338082 |
Constipation | 67.49 | 37.47 | 60 | 6465 | 21569 | 2329991 |
Gait disturbance | 67.31 | 37.47 | 61 | 6464 | 22484 | 2329076 |
Amnesia | 67.05 | 37.47 | 39 | 6486 | 7214 | 2344346 |
Generalised tonic-clonic seizure | 66.45 | 37.47 | 35 | 6490 | 5337 | 2346223 |
Cognitive disorder | 66.40 | 37.47 | 35 | 6490 | 5346 | 2346214 |
Blood pressure decreased | 65.72 | 37.47 | 42 | 6483 | 9194 | 2342366 |
Syncope | 65.33 | 37.47 | 53 | 6472 | 16822 | 2334738 |
Accidental overdose | 64.15 | 37.47 | 31 | 6494 | 3941 | 2347619 |
Aphasia | 63.50 | 37.47 | 33 | 6492 | 4895 | 2346665 |
Electrocardiogram QRS complex shortened | 62.99 | 37.47 | 13 | 6512 | 86 | 2351474 |
Rhabdomyolysis | 61.84 | 37.47 | 36 | 6489 | 6668 | 2344892 |
Paranoia | 61.78 | 37.47 | 25 | 6500 | 2082 | 2349478 |
Mania | 61.55 | 37.47 | 26 | 6499 | 2414 | 2349146 |
Drug screen positive | 61.23 | 37.47 | 20 | 6505 | 900 | 2350660 |
Purpura senile | 59.57 | 37.47 | 10 | 6515 | 15 | 2351545 |
Delirium | 58.90 | 37.47 | 32 | 6493 | 5191 | 2346369 |
Pregnancy | 58.67 | 37.47 | 37 | 6488 | 7912 | 2343648 |
Drug screen negative | 58.32 | 37.47 | 12 | 6513 | 78 | 2351482 |
Dysphagia | 57.71 | 37.47 | 44 | 6481 | 12761 | 2338799 |
Respiratory rate decreased | 57.22 | 37.47 | 17 | 6508 | 557 | 2351003 |
Incontinence | 55.90 | 37.47 | 21 | 6504 | 1433 | 2350127 |
Hepatitis | 55.74 | 37.47 | 33 | 6492 | 6304 | 2345256 |
Mental disorder | 55.00 | 37.47 | 28 | 6497 | 3979 | 2347581 |
Arrhythmia | 54.62 | 37.47 | 32 | 6493 | 5996 | 2345564 |
Treatment noncompliance | 54.46 | 37.47 | 31 | 6494 | 5503 | 2346057 |
Alanine aminotransferase increased | 54.15 | 37.47 | 44 | 6481 | 13988 | 2337572 |
Developmental glaucoma | 52.66 | 37.47 | 9 | 6516 | 16 | 2351544 |
Delusion | 52.07 | 37.47 | 22 | 6503 | 2043 | 2349517 |
Intellectual disability | 51.98 | 37.47 | 12 | 6513 | 141 | 2351419 |
Anger | 51.13 | 37.47 | 23 | 6502 | 2484 | 2349076 |
Hypoxia | 51.07 | 37.47 | 31 | 6494 | 6196 | 2345364 |
Pneumonia | 50.60 | 37.47 | 77 | 6448 | 49219 | 2302341 |
Body temperature decreased | 50.47 | 37.47 | 19 | 6506 | 1304 | 2350256 |
Weight decreased | 50.36 | 37.47 | 58 | 6467 | 28313 | 2323247 |
Hypersomnia | 49.19 | 37.47 | 22 | 6503 | 2344 | 2349216 |
Hypotonia | 48.91 | 37.47 | 20 | 6505 | 1710 | 2349850 |
Palpitations | 48.06 | 37.47 | 44 | 6481 | 16412 | 2335148 |
Off label use | 47.99 | 37.47 | 94 | 6431 | 73504 | 2278056 |
Tarsal tunnel syndrome | 47.79 | 37.47 | 9 | 6516 | 34 | 2351526 |
Dyskinesia | 47.59 | 37.47 | 27 | 6498 | 4762 | 2346798 |
Soft tissue haemorrhage | 47.58 | 37.47 | 9 | 6516 | 35 | 2351525 |
Pupil fixed | 47.56 | 37.47 | 14 | 6511 | 444 | 2351116 |
Product use in unapproved indication | 47.22 | 37.47 | 37 | 6488 | 11163 | 2340397 |
Dehydration | 47.20 | 37.47 | 50 | 6475 | 22245 | 2329315 |
Paradoxical drug reaction | 47.11 | 37.47 | 14 | 6511 | 459 | 2351101 |
Fear | 47.08 | 37.47 | 22 | 6503 | 2594 | 2348966 |
Muscle spasms | 46.79 | 37.47 | 49 | 6476 | 21517 | 2330043 |
Hepatic necrosis | 46.22 | 37.47 | 17 | 6508 | 1093 | 2350467 |
Akathisia | 46.13 | 37.47 | 19 | 6506 | 1655 | 2349905 |
Blood creatine phosphokinase increased | 45.83 | 37.47 | 27 | 6498 | 5109 | 2346451 |
Urinary retention | 45.65 | 37.47 | 24 | 6501 | 3643 | 2347917 |
Nightmare | 45.47 | 37.47 | 24 | 6501 | 3673 | 2347887 |
Aspartate aminotransferase increased | 45.42 | 37.47 | 38 | 6487 | 12574 | 2338986 |
Multiple organ dysfunction syndrome | 45.26 | 37.47 | 31 | 6494 | 7610 | 2343950 |
Substance abuse | 45.06 | 37.47 | 14 | 6511 | 535 | 2351025 |
Blood pressure increased | 44.96 | 37.47 | 43 | 6482 | 16943 | 2334617 |
Blood sodium decreased | 43.53 | 37.47 | 22 | 6503 | 3078 | 2348482 |
Electroencephalogram abnormal | 43.26 | 37.47 | 15 | 6510 | 812 | 2350748 |
Drug withdrawal syndrome neonatal | 43.24 | 37.47 | 13 | 6512 | 444 | 2351116 |
Coordination abnormal | 42.98 | 37.47 | 19 | 6506 | 1969 | 2349591 |
Decreased appetite | 42.97 | 37.47 | 54 | 6471 | 28837 | 2322723 |
Hyperreflexia | 42.00 | 37.47 | 15 | 6510 | 886 | 2350674 |
Emotional disorder | 41.33 | 37.47 | 19 | 6506 | 2158 | 2349402 |
No adverse event | 41.30 | 37.47 | 32 | 6493 | 9496 | 2342064 |
Parkinsonism | 41.19 | 37.47 | 17 | 6508 | 1488 | 2350072 |
Drug resistance | 40.92 | 37.47 | 20 | 6505 | 2604 | 2348956 |
Paraesthesia | 40.61 | 37.47 | 46 | 6479 | 22042 | 2329518 |
Hypoaesthesia | 40.43 | 37.47 | 44 | 6481 | 20171 | 2331389 |
Antipsychotic drug level increased | 40.43 | 37.47 | 13 | 6512 | 556 | 2351004 |
Toxic leukoencephalopathy | 40.04 | 37.47 | 9 | 6516 | 93 | 2351467 |
Loss of personal independence in daily activities | 39.88 | 37.47 | 25 | 6500 | 5286 | 2346274 |
Therapeutic product effect decreased | 39.87 | 37.47 | 33 | 6492 | 10756 | 2340804 |
Hypomania | 39.76 | 37.47 | 14 | 6511 | 793 | 2350767 |
Metabolic acidosis | 39.52 | 37.47 | 26 | 6499 | 5972 | 2345588 |
Dyspnoea | 39.08 | 37.47 | 90 | 6435 | 78643 | 2272917 |
Crying | 38.93 | 37.47 | 23 | 6502 | 4373 | 2347187 |
Skin abrasion | 38.75 | 37.47 | 15 | 6510 | 1110 | 2350450 |
Hypophagia | 38.26 | 37.47 | 22 | 6503 | 3978 | 2347582 |
Epileptic encephalopathy | 38.16 | 37.47 | 7 | 6518 | 22 | 2351538 |
Incoherent | 38.04 | 37.47 | 14 | 6511 | 901 | 2350659 |
Pyrexia | 37.92 | 37.47 | 71 | 6454 | 53637 | 2297923 |
Depressed mood | 37.86 | 37.47 | 24 | 6501 | 5174 | 2346386 |
Alcohol poisoning | 37.85 | 37.47 | 11 | 6514 | 333 | 2351227 |
Epilepsy | 37.79 | 37.47 | 23 | 6502 | 4616 | 2346944 |
Panic disorder | 37.67 | 37.47 | 12 | 6513 | 498 | 2351062 |
Drug withdrawal convulsions | 37.54 | 37.47 | 11 | 6514 | 343 | 2351217 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 3128.06 | 43.16 | 812 | 3651 | 15500 | 1726818 |
Toxicity to various agents | 2832.84 | 43.16 | 851 | 3612 | 28290 | 1714028 |
Drug abuse | 1905.20 | 43.16 | 533 | 3930 | 13156 | 1729162 |
Respiratory arrest | 1055.13 | 43.16 | 281 | 4182 | 5558 | 1736760 |
Cardio-respiratory arrest | 1021.75 | 43.16 | 303 | 4160 | 8990 | 1733328 |
Cardiac arrest | 931.07 | 43.16 | 321 | 4142 | 15609 | 1726709 |
Overdose | 646.98 | 43.16 | 249 | 4214 | 16452 | 1725866 |
Death | 551.41 | 43.16 | 381 | 4082 | 87062 | 1655256 |
Intentional product misuse | 469.20 | 43.16 | 159 | 4304 | 7199 | 1735119 |
Drug ineffective | 390.13 | 43.16 | 274 | 4189 | 63527 | 1678791 |
Poisoning | 349.33 | 43.16 | 99 | 4364 | 2433 | 1739885 |
Intentional overdose | 322.99 | 43.16 | 122 | 4341 | 7548 | 1734770 |
Seizure | 315.12 | 43.16 | 160 | 4303 | 20281 | 1722037 |
Suicide attempt | 309.30 | 43.16 | 117 | 4346 | 7264 | 1735054 |
Coma | 303.87 | 43.16 | 115 | 4348 | 7147 | 1735171 |
Sedation | 303.20 | 43.16 | 95 | 4368 | 3322 | 1738996 |
Somnolence | 293.26 | 43.16 | 143 | 4320 | 16596 | 1725722 |
Drug interaction | 291.98 | 43.16 | 169 | 4294 | 27789 | 1714529 |
Anxiety | 266.93 | 43.16 | 131 | 4332 | 15396 | 1726922 |
Respiratory depression | 248.36 | 43.16 | 74 | 4389 | 2173 | 1740145 |
Depressed level of consciousness | 242.12 | 43.16 | 95 | 4368 | 6497 | 1735821 |
Unresponsive to stimuli | 225.34 | 43.16 | 82 | 4381 | 4547 | 1737771 |
Agitation | 198.14 | 43.16 | 96 | 4367 | 10930 | 1731388 |
Depression | 190.20 | 43.16 | 107 | 4356 | 16562 | 1725756 |
Aggression | 177.62 | 43.16 | 81 | 4382 | 8034 | 1734284 |
Hypotension | 169.54 | 43.16 | 123 | 4340 | 29531 | 1712787 |
Confusional state | 161.09 | 43.16 | 105 | 4358 | 21173 | 1721145 |
Neuroleptic malignant syndrome | 157.71 | 43.16 | 57 | 4406 | 3091 | 1739227 |
Substance abuse | 155.38 | 43.16 | 43 | 4420 | 960 | 1741358 |
Serotonin syndrome | 152.94 | 43.16 | 54 | 4409 | 2734 | 1739584 |
Insomnia | 149.93 | 43.16 | 91 | 4372 | 16185 | 1726133 |
Ataxia | 142.23 | 43.16 | 49 | 4414 | 2304 | 1740014 |
Loss of consciousness | 136.54 | 43.16 | 83 | 4380 | 14792 | 1727526 |
Status epilepticus | 133.01 | 43.16 | 45 | 4418 | 2001 | 1740317 |
Fall | 126.82 | 43.16 | 100 | 4363 | 27114 | 1715204 |
Abnormal behaviour | 122.20 | 43.16 | 58 | 4405 | 6284 | 1736034 |
Accidental overdose | 111.73 | 43.16 | 48 | 4415 | 4116 | 1738202 |
Drug dependence | 108.24 | 43.16 | 44 | 4419 | 3283 | 1739035 |
Encephalopathy | 105.42 | 43.16 | 47 | 4416 | 4405 | 1737913 |
Parkinsonism | 104.51 | 43.16 | 34 | 4429 | 1335 | 1740983 |
Speech disorder | 104.46 | 43.16 | 47 | 4416 | 4501 | 1737817 |
Muscle rigidity | 102.10 | 43.16 | 36 | 4427 | 1812 | 1740506 |
Tachycardia | 99.50 | 43.16 | 64 | 4399 | 12564 | 1729754 |
Pulmonary oedema | 99.36 | 43.16 | 51 | 4412 | 6535 | 1735783 |
Drug withdrawal syndrome | 98.35 | 43.16 | 45 | 4418 | 4480 | 1737838 |
Dysarthria | 94.91 | 43.16 | 46 | 4417 | 5213 | 1737105 |
Condition aggravated | 94.72 | 43.16 | 76 | 4387 | 21074 | 1721244 |
Gait disturbance | 94.39 | 43.16 | 62 | 4401 | 12608 | 1729710 |
Medication error | 93.24 | 43.16 | 44 | 4419 | 4699 | 1737619 |
Disinhibition | 93.20 | 43.16 | 23 | 4440 | 321 | 1741997 |
Mental status changes | 91.51 | 43.16 | 47 | 4416 | 6028 | 1736290 |
Exposure via ingestion | 90.96 | 43.16 | 26 | 4437 | 654 | 1741664 |
Electrocardiogram QT prolonged | 89.64 | 43.16 | 45 | 4418 | 5500 | 1736818 |
Intentional self-injury | 89.16 | 43.16 | 36 | 4427 | 2637 | 1739681 |
Brain oedema | 88.80 | 43.16 | 34 | 4429 | 2162 | 1740156 |
Acute pulmonary oedema | 87.95 | 43.16 | 29 | 4434 | 1188 | 1741130 |
Tremor | 87.59 | 43.16 | 60 | 4403 | 13071 | 1729247 |
Disturbance in attention | 85.44 | 43.16 | 40 | 4423 | 4194 | 1738124 |
Bradycardia | 84.47 | 43.16 | 54 | 4409 | 10480 | 1731838 |
Suicidal ideation | 81.83 | 43.16 | 49 | 4414 | 8469 | 1733849 |
Generalised tonic-clonic seizure | 80.95 | 43.16 | 38 | 4425 | 4008 | 1738310 |
Hyperhidrosis | 80.78 | 43.16 | 56 | 4407 | 12432 | 1729886 |
Epilepsy | 78.64 | 43.16 | 37 | 4426 | 3922 | 1738396 |
Dystonia | 77.21 | 43.16 | 30 | 4433 | 1984 | 1740334 |
Acute respiratory distress syndrome | 76.16 | 43.16 | 35 | 4428 | 3516 | 1738802 |
Dyskinesia | 73.73 | 43.16 | 35 | 4428 | 3784 | 1738534 |
Poisoning deliberate | 68.69 | 43.16 | 22 | 4441 | 820 | 1741498 |
Asterixis | 67.80 | 43.16 | 17 | 4446 | 254 | 1742064 |
Salivary hypersecretion | 67.64 | 43.16 | 25 | 4438 | 1440 | 1740878 |
Myoclonus | 66.65 | 43.16 | 28 | 4435 | 2267 | 1740051 |
Psychotic disorder | 64.44 | 43.16 | 35 | 4428 | 5021 | 1737297 |
Respiratory failure | 60.38 | 43.16 | 50 | 4413 | 14455 | 1727863 |
Blood creatine phosphokinase increased | 60.27 | 43.16 | 41 | 4422 | 8815 | 1733503 |
Miosis | 60.16 | 43.16 | 23 | 4440 | 1455 | 1740863 |
Drug screen positive | 59.93 | 43.16 | 21 | 4442 | 1036 | 1741282 |
Hyponatraemia | 59.67 | 43.16 | 41 | 4422 | 8959 | 1733359 |
Off label use | 59.56 | 43.16 | 78 | 4385 | 38493 | 1703825 |
Dysmetria | 59.36 | 43.16 | 12 | 4451 | 61 | 1742257 |
Personality disorder | 58.86 | 43.16 | 15 | 4448 | 240 | 1742078 |
Hypotonia | 58.81 | 43.16 | 23 | 4440 | 1547 | 1740771 |
Illness anxiety disorder | 58.53 | 43.16 | 11 | 4452 | 35 | 1742283 |
Treatment noncompliance | 58.06 | 43.16 | 33 | 4430 | 5168 | 1737150 |
Foetal exposure during pregnancy | 56.97 | 43.16 | 35 | 4428 | 6324 | 1735994 |
Withdrawal syndrome | 56.85 | 43.16 | 25 | 4438 | 2263 | 1740055 |
Multiple-drug resistance | 55.96 | 43.16 | 15 | 4448 | 295 | 1742023 |
Catatonia | 55.66 | 43.16 | 19 | 4444 | 866 | 1741452 |
Thinking abnormal | 55.50 | 43.16 | 21 | 4442 | 1291 | 1741027 |
Memory impairment | 55.47 | 43.16 | 35 | 4428 | 6628 | 1735690 |
Drug level increased | 55.28 | 43.16 | 26 | 4437 | 2751 | 1739567 |
Electrocardiogram QRS complex prolonged | 54.11 | 43.16 | 18 | 4445 | 757 | 1741561 |
Postictal paralysis | 53.40 | 43.16 | 10 | 4453 | 31 | 1742287 |
Restlessness | 52.53 | 43.16 | 29 | 4434 | 4292 | 1738026 |
Panic attack | 51.79 | 43.16 | 22 | 4441 | 1830 | 1740488 |
Sleep apnoea syndrome | 51.78 | 43.16 | 23 | 4440 | 2131 | 1740187 |
Sinus tachycardia | 51.30 | 43.16 | 24 | 4439 | 2508 | 1739810 |
Rhabdomyolysis | 49.86 | 43.16 | 40 | 4423 | 11050 | 1731268 |
Intentional product use issue | 49.67 | 43.16 | 24 | 4439 | 2695 | 1739623 |
Delirium | 49.43 | 43.16 | 32 | 4431 | 6330 | 1735988 |
Mental disorder | 48.65 | 43.16 | 24 | 4439 | 2819 | 1739499 |
Lethargy | 48.25 | 43.16 | 33 | 4430 | 7151 | 1735167 |
Product substitution issue | 48.22 | 43.16 | 25 | 4438 | 3261 | 1739057 |
Respiratory acidosis | 48.12 | 43.16 | 16 | 4447 | 672 | 1741646 |
Fatigue | 47.21 | 43.16 | 81 | 4382 | 50700 | 1691618 |
Pneumonia aspiration | 47.20 | 43.16 | 29 | 4434 | 5237 | 1737081 |
Cognitive disorder | 47.05 | 43.16 | 27 | 4436 | 4303 | 1738015 |
Hyperthermia | 46.99 | 43.16 | 20 | 4443 | 1671 | 1740647 |
Disorientation | 46.19 | 43.16 | 29 | 4434 | 5440 | 1736878 |
Drooling | 46.01 | 43.16 | 16 | 4447 | 771 | 1741547 |
Product complaint | 45.55 | 43.16 | 22 | 4441 | 2468 | 1739850 |
Feeling of despair | 45.30 | 43.16 | 12 | 4451 | 225 | 1742093 |
Apathy | 45.08 | 43.16 | 18 | 4445 | 1278 | 1741040 |
Depression suicidal | 44.90 | 43.16 | 12 | 4451 | 233 | 1742085 |
Altered state of consciousness | 43.97 | 43.16 | 24 | 4439 | 3473 | 1738845 |
Source | Code | Description |
---|---|---|
ATC | N03AE01 | NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Benzodiazepine derivatives |
CHEBI has role | CHEBI:35623 | anticonvulsant |
CHEBI has role | CHEBI:50268 | GABA modulator |
CHEBI has role | CHEBI:35474 | anxiolytic drug |
MeSH PA | D000927 | Anticonvulsants |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D018682 | GABA Agents |
MeSH PA | D018757 | GABA Modulators |
MeSH PA | D018377 | Neurotransmitter Agents |
FDA EPC | N0000175694 | Benzodiazepine |
FDA CS | M0002356 | Benzodiazepines |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Myoclonic seizure | indication | 37356005 | |
Atonic seizure | indication | 42365007 | |
Absence seizure | indication | 79631006 | |
Lennox-Gastaut syndrome | indication | 230418006 | |
Panic disorder | indication | 371631005 | DOID:594 |
Akathisia | off-label use | 285145004 | |
Manic Bipolar Disorder Adjunct Treatment | off-label use | ||
Suicidal thoughts | contraindication | 6471006 | |
Alcohol intoxication | contraindication | 25702006 | |
Depressive disorder | contraindication | 35489007 | |
Hepatic failure | contraindication | 59927004 | |
Substance abuse | contraindication | 66214007 | |
Sleep apnea | contraindication | 73430006 | DOID:0050847 |
Decreased respiratory function | contraindication | 80954004 | |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Liver function tests abnormal | contraindication | 166603001 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Syncope | contraindication | 271594007 | |
Pregnancy, function | contraindication | 289908002 | |
At risk for aspiration | contraindication | 371736008 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Breastfeeding (mother) | contraindication | 413712001 | |
Chronic lung disease | contraindication | 413839001 | |
Central nervous system depression | contraindication | 418072004 | |
Porphyria | contraindication | 418470004 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 10.65 | acidic |
pKa2 | 1.65 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
GABA-A receptor alpha-1/beta-2/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 8.07 | WOMBAT-PK | CHEMBL | |||
GABA-A receptor; anion channel | Ion channel | Ki | 9.07 | CHEMBL | |||||
GABA-A receptor; anion channel | Ion channel | IC50 | 8.77 | CHEMBL | |||||
GABA-A receptor; anion channel | Ion channel | Ki | 9.07 | CHEMBL |
ID | Source |
---|---|
D002998 | MESH_DESCRIPTOR_UI |
4017791 | VUID |
N0000146152 | NUI |
C0009011 | UMLSCUI |
D00280 | KEGG_DRUG |
5PE9FDE8GB | UNII |
2765 | INN_ID |
69708003 | SNOMEDCT_US |
4017791 | VANDF |
001635 | NDDF |
2598 | RXNORM |
377 | MMSL |
d00197 | MMSL |
387383007 | SNOMEDCT_US |
4477 | MMSL |
CHEMBL452 | ChEMBL_ID |
DB01068 | DRUGBANK_ID |
CHEBI:3756 | CHEBI |
6963 | IUPHAR_LIGAND_ID |
2802 | PUBCHEM_CID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Klonopin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0004-0058 | TABLET | 1 mg | ORAL | NDA | 15 sections |
Klonopin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0004-0068 | TABLET | 0.50 mg | ORAL | NDA | 15 sections |
Klonopin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0004-0098 | TABLET | 2 mg | ORAL | NDA | 15 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0832 | TABLET | 0.50 mg | ORAL | ANDA | 14 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3212 | TABLET | 1 mg | ORAL | ANDA | 14 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3213 | TABLET | 2 mg | ORAL | ANDA | 14 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0063 | TABLET | 0.50 mg | ORAL | ANDA | 14 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0064 | TABLET | 1 mg | ORAL | ANDA | 14 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0065 | TABLET | 2 mg | ORAL | ANDA | 14 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-3003 | TABLET | 0.50 mg | ORAL | ANDA | 15 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-3004 | TABLET | 1 mg | ORAL | ANDA | 15 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-3005 | TABLET | 2 mg | ORAL | ANDA | 15 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1910 | TABLET | 0.50 mg | ORAL | ANDA | 14 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1912 | TABLET | 1 mg | ORAL | ANDA | 14 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1914 | TABLET | 2 mg | ORAL | ANDA | 14 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0094 | TABLET, ORALLY DISINTEGRATING | 0.13 mg | ORAL | ANDA | 15 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0095 | TABLET, ORALLY DISINTEGRATING | 0.25 mg | ORAL | ANDA | 15 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0096 | TABLET, ORALLY DISINTEGRATING | 0.50 mg | ORAL | ANDA | 15 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0097 | TABLET, ORALLY DISINTEGRATING | 1 mg | ORAL | ANDA | 15 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0098 | TABLET, ORALLY DISINTEGRATING | 2 mg | ORAL | ANDA | 15 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7796 | TABLET | 0.50 mg | ORAL | ANDA | 14 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8001 | TABLET | 0.50 mg | ORAL | ANDA | 13 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8002 | TABLET | 1 mg | ORAL | ANDA | 13 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8048 | TABLET | 2 mg | ORAL | ANDA | 13 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8227 | TABLET | 0.50 mg | ORAL | ANDA | 15 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8234 | TABLET | 0.50 mg | ORAL | ANDA | 13 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8235 | TABLET | 1 mg | ORAL | ANDA | 13 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8236 | TABLET | 2 mg | ORAL | ANDA | 13 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5567 | TABLET | 1 mg | ORAL | ANDA | 14 sections |
Clonazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5569 | TABLET | 2 mg | ORAL | ANDA | 14 sections |