clofibrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
clofibrate derivatives, peroxisome proliferator activated receptor-alpha(PPAR-alpha) agonists 694 637-07-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clofibrate
  • ticlobran
  • xyduril
  • p-chlorophenoxyisobutyric acid ethyl ester
  • lipavil
  • lipavlon
  • lipomid
  • liprinal
  • miscleron
  • misclerone
A fibric acid derivative used in the treatment of HYPERLIPOPROTEINEMIA TYPE III and severe HYPERTRIGLYCERIDEMIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986)
  • Molecular weight: 242.70
  • Formula: C12H15ClO3
  • CLOGP: 3.68
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 35.53
  • ALOGS: -3.92
  • ROTB: 5

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 11 % Benet LZ, Broccatelli F, Oprea TI
BA (Bioavailability) 95 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Feb. 8, 1967 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C10AB01 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
Fibrates
CHEBI has role CHEBI:35679 antilipemic drugs
CHEBI has role CHEBI:35821 anticholesteremic drugs
CHEBI has role CHEBI:70782 PPAR-alpha agonist
CHEBI has role CHEBI:176497 geroprotectors
MeSH PA D000924 Anticholesteremic Agents
MeSH PA D000963 Antimetabolites
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D057847 Lipid Regulating Agents
CHEBI has role CHEBI:24527 herbicides
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:83399 marine xenobiotic metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hyperlipidemia indication 55822004 DOID:1168
Partial Central Diabetes Insipidus off-label use




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Peroxisome proliferator-activated receptor alpha Nuclear hormone receptor AGONIST IC50 4.25 IUPHAR CHEMBL
Fatty acid-binding protein, liver Unclassified Kd 5.22 CHEMBL

External reference:

IDSource
4018482 VUID
N0000146804 NUI
D00279 KEGG_DRUG
2594 RXNORM
4018482 VANDF
C0009002 UMLSCUI
CHEBI:3750 CHEBI
CHEBI:34648 CHEBI
CHEMBL565 ChEMBL_ID
DB00636 DRUGBANK_ID
D002994 MESH_DESCRIPTOR_UI
2796 PUBCHEM_CID
2667 IUPHAR_LIGAND_ID
1530 INN_ID
HPN91K7FU3 UNII
2797 PUBCHEM_CID
348 MMSL
4474 MMSL
d00196 MMSL
002056 NDDF
387439004 SNOMEDCT_US
77035009 SNOMEDCT_US
C0009003 UMLSCUI
D002995 MESH_DESCRIPTOR_UI
2439 INN_ID

Pharmaceutical products:

None