simfibrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
clofibrate derivatives, peroxisome proliferator activated receptor-alpha(PPAR-alpha) agonists 2444 14929-11-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • simfibrate
  • cholesolvin
  • clofibric acid trimethylene ester
  • Molecular weight: 469.36
  • Formula: C23H26Cl2O6
  • CLOGP: 6.71
  • LIPINSKI: 1
  • HAC: 6
  • HDO: 0
  • TPSA: 71.06
  • ALOGS: -6.41
  • ROTB: 12

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C10AB06 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
Fibrates
MeSH PA D000963 Antimetabolites
MeSH PA D000924 Anticholesteremic Agents
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D057847 Lipid Regulating Agents
CHEBI has role CHEBI:24527 herbicides
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35679 antilipemic drugs
CHEBI has role CHEBI:35821 anticholesteremic drugs
CHEBI has role CHEBI:70782 PPAR-alpha agonist
CHEBI has role CHEBI:83399 marine xenobiotic metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01212 KEGG_DRUG
C0074551 UMLSCUI
CHEBI:32131 CHEBI
CHEBI:34648 CHEBI
CHEMBL2105435 ChEMBL_ID
DB13433 DRUGBANK_ID
C003278 MESH_SUPPLEMENTAL_RECORD_UI
2732 INN_ID
L2R75RQX26 UNII
5217 PUBCHEM_CID
C0009003 UMLSCUI
2439 INN_ID
2797 PUBCHEM_CID
D002995 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None