clioquinol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| quinoline derivatives | 681 | 130-26-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D08AH30 | DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Quinoline derivatives |
| ATC | D09AA10 | DERMATOLOGICALS MEDICATED DRESSINGS MEDICATED DRESSINGS Medicated dressings with antiinfectives |
| ATC | G01AC02 | GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Quinoline derivatives |
| ATC | P01AA02 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTIPROTOZOALS AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES Hydroxyquinoline derivatives |
| ATC | P01AA52 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTIPROTOZOALS AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES Hydroxyquinoline derivatives |
| ATC | S02AA05 | SENSORY ORGANS OTOLOGICALS ANTIINFECTIVES Antiinfectives |
| FDA CS | M0000728 | Allergens |
| FDA PE | N0000175629 | Increased Histamine Release |
| FDA PE | N0000184306 | Cell-mediated Immunity |
| FDA EPC | N0000185508 | Standardized Chemical Allergen |
| CHEBI has role | CHEBI:33281 | antibiotics |
| CHEBI has role | CHEBI:33282 | bactericides |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:35718 | antifungal agents |
| CHEBI has role | CHEBI:35820 | antiprotozoal drugs |
| CHEBI has role | CHEBI:38161 | Chelating agent |
| CHEBI has role | CHEBI:166831 | copper chelator |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Tinea pedis | indication | 6020002 | DOID:12403 |
| Tinea corporis | indication | 84849002 | |
| Tinea cruris | indication | 399029005 | |
| Open wound | contraindication | 125643001 | |
| Telangiectasia disorder | contraindication | 247479008 | |
| Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
| Atrophoderma | contraindication | 399979006 | |
| Peripheral vascular disease | contraindication | 400047006 |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Horses | Diarrhea | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Rheaform Bolus | Zoetis Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.63 | acidic |
| pKa2 | 2.39 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Amyloid beta A4 protein | Unclassified | IC50 | 4 | CHEMBL | |||||
| Catechol O-methyltransferase | Enzyme | IC50 | 5.32 | CHEMBL | |||||
| Botulinum neurotoxin type A | Enzyme | IC50 | 4.69 | CHEMBL | |||||
| Carbonic anhydrase 15 | Enzyme | Ki | 5.63 | CHEMBL | |||||
| Spike glycoprotein | Glycoprotein | IC50 | 5.25 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018572 | VUID |
| N0000146888 | NUI |
| D03538 | KEGG_DRUG |
| 5942 | RXNORM |
| 4018572 | VANDF |
| C0021978 | UMLSCUI |
| CHEBI:74460 | CHEBI |
| CQL | PDB_CHEM_ID |
| CHEMBL497 | ChEMBL_ID |
| DB04815 | DRUGBANK_ID |
| D007464 | MESH_DESCRIPTOR_UI |
| 2788 | PUBCHEM_CID |
| 2116 | INN_ID |
| 7BHQ856EJ5 | UNII |
| 4470 | MMSL |
| 6683 | MMSL |
| 002874 | NDDF |
| 387291001 | SNOMEDCT_US |
| 52896000 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| DERMOSCRIBE ICHYBUM | HUMAN OTC DRUG LABEL | 2 | 69683-101 | CREAM | 1 g | TOPICAL | OTC monograph not final | 9 sections |
| DERMOSCRIBE ICHYBUM | HUMAN OTC DRUG LABEL | 2 | 69683-101 | CREAM | 1 g | TOPICAL | OTC monograph not final | 9 sections |
| DERMOSCRIBE DIAPER | HUMAN OTC DRUG LABEL | 2 | 69683-102 | OINTMENT | 1 g | TOPICAL | OTC monograph not final | 9 sections |
| DERMOSCRIBE DIAPER | HUMAN OTC DRUG LABEL | 2 | 69683-102 | OINTMENT | 1 g | TOPICAL | OTC monograph not final | 9 sections |