DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
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L1000
FAQ
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
clebopride 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
sulpiride derivatives and analogues
670
55905-53-8
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
clebopride
clebopride maleate
antidopaminergic; RN given refers to parent cpd; structure
Molecular weight: 373.88
Formula: C20H24ClN3O2
CLOGP: 2.72
LIPINSKI: 0
HAC: 5
HDO: 2
TPSA: 67.59
ALOGS: -4.28
ROTB: 5
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Mixed liver injury
69.27
42.76
10
39
2863
34954019
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FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Mixed liver injury
66.95
46.30
10
43
7568
79736767
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
A03FA06
ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
PROPULSIVES
Propulsives
MeSH PA
D000932
Antiemetics
MeSH PA
D002491
Central Nervous System Agents
MeSH PA
D005765
Gastrointestinal Agents
MeSH PA
D018373
Peripheral Nervous System Agents
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
10.44
acidic
pKa2
7.98
Basic
pKa3
1.0
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
D(2) dopamine receptor
GPCR
P14416
DRD2_HUMAN
Ki
7.92
CHEMBL
Potassium voltage-gated channel subfamily H member 2
Ion channel
Q12809
KCNH2_HUMAN
IC50
6.22
CHEMBL
D(3) dopamine receptor
GPCR
P35462
DRD3_HUMAN
Ki
7.98
CHEMBL
D(4) dopamine receptor
GPCR
P21917
DRD4_HUMAN
Ki
8.49
CHEMBL
Acetylcholinesterase
Enzyme
P22303
ACES_HUMAN
IC50
6.05
CHEMBL
5-hydroxytryptamine receptor 4
GPCR
5HT4R_CAVPO
Ki
6.98
CHEMBL
D(2) dopamine receptor
GPCR
DRD2_RAT
Ki
8.95
CHEMBL
D(1A) dopamine receptor
GPCR
DRD1_BOVIN
Ki
5.22
CHEMBL
5-hydroxytryptamine receptor 4
GPCR
5HT4R_RAT
Ki
6.98
CHEMBL
Adrenergic receptor alpha-2
GPCR
ADA2B_RAT
ADA2C_RAT
ADA2A_RAT
Ki
6.22
CHEMBL
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External reference:
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ID
Source
006633
NDDF
006634
NDDF
21224
RXNORM
2780
PUBCHEM_CID
3699
INN_ID
84370-95-6
SECONDARY_CAS_RN
C0055869
UMLSCUI
C014417
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:92309
CHEBI
CHEMBL1599248
ChEMBL_ID
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Pharmaceutical products:
None
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clebopride