Stem definition | Drug id | CAS RN |
---|---|---|
beta-lactamase inhibitors | 669 | 58001-44-8 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 43 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 31.38 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 75 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.22 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 3.10 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.91 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 0.90 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 6, 1984 | FDA | DR REDDYS LABS INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Acute generalised exanthematous pustulosis | 87.24 | 15.36 | 40 | 9907 | 11059 | 63468016 |
Hepatitis cholestatic | 84.49 | 15.36 | 34 | 9913 | 6844 | 63472231 |
Bone erosion | 77.69 | 15.36 | 43 | 9904 | 17674 | 63461401 |
Bronchiectasis | 75.82 | 15.36 | 41 | 9906 | 16101 | 63462974 |
Drug hypersensitivity | 63.53 | 15.36 | 146 | 9801 | 310541 | 63168534 |
Drug reaction with eosinophilia and systemic symptoms | 60.95 | 15.36 | 47 | 9900 | 33789 | 63445286 |
Cholestasis | 59.94 | 15.36 | 44 | 9903 | 29390 | 63449685 |
Toxic skin eruption | 55.74 | 15.36 | 31 | 9916 | 12854 | 63466221 |
Jaundice | 55.70 | 15.36 | 42 | 9905 | 29209 | 63449866 |
Anaphylactic reaction | 50.68 | 15.36 | 57 | 9890 | 66043 | 63413032 |
Hypothyroidism | 45.70 | 15.36 | 44 | 9903 | 42588 | 63436487 |
Nail dystrophy | 44.07 | 15.36 | 13 | 9934 | 1030 | 63478045 |
Cholecystitis chronic | 42.30 | 15.36 | 24 | 9923 | 10337 | 63468738 |
Neutropenia | 41.06 | 15.36 | 87 | 9860 | 174918 | 63304157 |
Pruritus | 40.10 | 15.36 | 136 | 9811 | 361317 | 63117758 |
Axillary pain | 39.63 | 15.36 | 14 | 9933 | 1969 | 63477106 |
Acute kidney injury | 37.39 | 15.36 | 108 | 9839 | 263307 | 63215768 |
International normalised ratio increased | 33.82 | 15.36 | 39 | 9908 | 46386 | 63432689 |
Catheter site haemorrhage | 33.23 | 15.36 | 14 | 9933 | 3161 | 63475914 |
Hepatocellular injury | 32.67 | 15.36 | 30 | 9917 | 27351 | 63451724 |
Rash maculo-papular | 32.45 | 15.36 | 32 | 9915 | 31864 | 63447211 |
Appendicitis | 30.76 | 15.36 | 18 | 9929 | 8211 | 63470864 |
Clostridium difficile colitis | 29.46 | 15.36 | 25 | 9922 | 20544 | 63458531 |
Bone marrow eosinophilic leukocyte count increased | 28.81 | 15.36 | 5 | 9942 | 32 | 63479043 |
Toxic epidermal necrolysis | 28.76 | 15.36 | 27 | 9920 | 25307 | 63453768 |
Anaphylactic shock | 28.40 | 15.36 | 26 | 9921 | 23607 | 63455468 |
Allergic hepatitis | 27.94 | 15.36 | 5 | 9942 | 39 | 63479036 |
Odynophagia | 26.99 | 15.36 | 16 | 9931 | 7470 | 63471605 |
Emotional distress | 26.54 | 15.36 | 29 | 9918 | 32520 | 63446555 |
Dermatitis exfoliative | 26.00 | 15.36 | 14 | 9933 | 5445 | 63473630 |
Cholelithiasis | 25.65 | 15.36 | 33 | 9914 | 43892 | 63435183 |
Gamma-glutamyltransferase increased | 25.48 | 15.36 | 29 | 9918 | 34002 | 63445073 |
Purpura | 25.41 | 15.36 | 18 | 9929 | 11367 | 63467708 |
Injury | 25.33 | 15.36 | 43 | 9904 | 73204 | 63405871 |
Peripheral swelling | 24.10 | 15.36 | 6 | 9941 | 265936 | 63213139 |
Contraindicated product administered | 23.86 | 15.36 | 3 | 9944 | 217645 | 63261430 |
Blood alkaline phosphatase increased | 23.10 | 15.36 | 31 | 9916 | 42936 | 63436139 |
Abdominal discomfort | 22.64 | 15.36 | 11 | 9936 | 320874 | 63158201 |
Hyperleukocytosis | 22.35 | 15.36 | 7 | 9940 | 679 | 63478396 |
Hyperchlorhydria | 22.24 | 15.36 | 9 | 9938 | 1835 | 63477240 |
Arthropathy | 21.86 | 15.36 | 5 | 9942 | 234787 | 63244288 |
Stevens-Johnson syndrome | 21.69 | 15.36 | 23 | 9924 | 24927 | 63454148 |
Agranulocytosis | 21.55 | 15.36 | 23 | 9924 | 25111 | 63453964 |
Bronchospasm | 20.74 | 15.36 | 19 | 9928 | 17261 | 63461814 |
Linear IgA disease | 20.72 | 15.36 | 8 | 9939 | 1443 | 63477632 |
Thrombocytopenia | 20.47 | 15.36 | 61 | 9886 | 151096 | 63327979 |
Alopecia | 20.35 | 15.36 | 14 | 9933 | 337522 | 63141553 |
Off label use | 19.96 | 15.36 | 48 | 9899 | 674414 | 62804661 |
Eosinophilia | 19.82 | 15.36 | 21 | 9926 | 22735 | 63456340 |
Folate deficiency | 19.69 | 15.36 | 9 | 9938 | 2466 | 63476609 |
Mixed liver injury | 19.41 | 15.36 | 11 | 9936 | 4724 | 63474351 |
Meningitis aseptic | 19.22 | 15.36 | 11 | 9936 | 4812 | 63474263 |
Joint swelling | 19.22 | 15.36 | 14 | 9933 | 327652 | 63151423 |
Nasopharyngitis | 19.04 | 15.36 | 8 | 9939 | 254249 | 63224826 |
Pemphigus | 19.04 | 15.36 | 3 | 9944 | 183723 | 63295352 |
Aspartate aminotransferase increased | 19.00 | 15.36 | 43 | 9904 | 90234 | 63388841 |
Deep vein thrombosis | 18.86 | 15.36 | 41 | 9906 | 83759 | 63395316 |
Product dose omission issue | 18.16 | 15.36 | 7 | 9940 | 234306 | 63244769 |
Alanine aminotransferase increased | 18.15 | 15.36 | 46 | 9901 | 103724 | 63375351 |
Hydronephrosis | 17.44 | 15.36 | 14 | 9933 | 10648 | 63468427 |
Hypokalaemia | 17.10 | 15.36 | 45 | 9902 | 103759 | 63375316 |
Loss of personal independence in daily activities | 16.88 | 15.36 | 43 | 9904 | 97247 | 63381828 |
Red blood cell sedimentation rate abnormal | 16.78 | 15.36 | 18 | 9929 | 19764 | 63459311 |
Ejection fraction decreased | 16.66 | 15.36 | 19 | 9928 | 22313 | 63456762 |
Strawberry tongue | 16.38 | 15.36 | 3 | 9944 | 27 | 63479048 |
Glossodynia | 16.27 | 15.36 | 4 | 9943 | 178872 | 63300203 |
Erythema | 15.92 | 15.36 | 62 | 9885 | 175689 | 63303386 |
Dementia | 15.76 | 15.36 | 17 | 9930 | 18777 | 63460298 |
Chondroma | 15.67 | 15.36 | 3 | 9944 | 35 | 63479040 |
Veillonella infection | 15.67 | 15.36 | 3 | 9944 | 35 | 63479040 |
Chromaturia | 15.58 | 15.36 | 16 | 9931 | 16701 | 63462374 |
Osteolysis | 15.47 | 15.36 | 8 | 9939 | 2866 | 63476209 |
Thrombotic microangiopathy | 15.46 | 15.36 | 13 | 9934 | 10548 | 63468527 |
Pyrexia | 15.40 | 15.36 | 126 | 9821 | 470352 | 63008723 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hepatocellular injury | 143.18 | 16.72 | 78 | 7627 | 22133 | 34927093 |
Cholestasis | 108.89 | 16.72 | 70 | 7635 | 26878 | 34922348 |
Jaundice | 78.04 | 16.72 | 61 | 7644 | 31821 | 34917405 |
Spinal muscular atrophy | 67.48 | 16.72 | 16 | 7689 | 380 | 34948846 |
Motor neurone disease | 63.24 | 16.72 | 16 | 7689 | 501 | 34948725 |
Hepatitis cholestatic | 62.78 | 16.72 | 32 | 7673 | 7915 | 34941311 |
Pneumococcal sepsis | 59.21 | 16.72 | 18 | 7687 | 1119 | 34948107 |
Stoma closure | 56.67 | 16.72 | 13 | 7692 | 266 | 34948960 |
Anaphylactic shock | 53.70 | 16.72 | 37 | 7668 | 15904 | 34933322 |
Ischaemic cerebral infarction | 53.41 | 16.72 | 17 | 7688 | 1230 | 34947996 |
Lymphadenectomy | 52.44 | 16.72 | 13 | 7692 | 374 | 34948852 |
Purpura | 52.33 | 16.72 | 31 | 7674 | 10280 | 34938946 |
Lower respiratory tract infection bacterial | 49.11 | 16.72 | 13 | 7692 | 488 | 34948738 |
Bronchial disorder | 47.47 | 16.72 | 16 | 7689 | 1387 | 34947839 |
Urethral valves | 45.85 | 16.72 | 11 | 7694 | 275 | 34948951 |
Increased bronchial secretion | 42.88 | 16.72 | 16 | 7689 | 1865 | 34947361 |
Sputum increased | 39.29 | 16.72 | 16 | 7689 | 2354 | 34946872 |
Drug reaction with eosinophilia and systemic symptoms | 38.98 | 16.72 | 42 | 7663 | 32970 | 34916256 |
Hepatic cytolysis | 38.20 | 16.72 | 29 | 7676 | 14467 | 34934759 |
Toxic epidermal necrolysis | 37.60 | 16.72 | 34 | 7671 | 21612 | 34927614 |
Disease complication | 37.07 | 16.72 | 16 | 7689 | 2720 | 34946506 |
Scoliosis | 36.76 | 16.72 | 16 | 7689 | 2777 | 34946449 |
Hepatitis | 36.60 | 16.72 | 35 | 7670 | 23869 | 34925357 |
Resuscitation | 35.48 | 16.72 | 13 | 7692 | 1440 | 34947786 |
Rash maculo-papular | 35.01 | 16.72 | 37 | 7668 | 28414 | 34920812 |
Demyelination | 34.57 | 16.72 | 16 | 7689 | 3205 | 34946021 |
Anaphylactic reaction | 34.51 | 16.72 | 39 | 7666 | 32262 | 34916964 |
Jaundice cholestatic | 34.11 | 16.72 | 18 | 7687 | 4776 | 34944450 |
Respiratory tract infection bacterial | 32.90 | 16.72 | 13 | 7692 | 1769 | 34947457 |
Stevens-Johnson syndrome | 31.82 | 16.72 | 29 | 7676 | 18610 | 34930616 |
Motor dysfunction | 30.33 | 16.72 | 19 | 7686 | 6955 | 34942271 |
Metabolic disorder | 30.24 | 16.72 | 16 | 7689 | 4267 | 34944959 |
Chest X-ray abnormal | 29.84 | 16.72 | 16 | 7689 | 4382 | 34944844 |
Pruritus | 29.43 | 16.72 | 83 | 7622 | 141898 | 34807328 |
Circulatory collapse | 28.84 | 16.72 | 29 | 7676 | 21009 | 34928217 |
Inflammation | 28.26 | 16.72 | 33 | 7672 | 28262 | 34920964 |
Off label use | 27.84 | 16.72 | 31 | 7674 | 419493 | 34529733 |
Brain injury | 27.39 | 16.72 | 17 | 7688 | 6125 | 34943101 |
Blood alkaline phosphatase increased | 27.29 | 16.72 | 34 | 7671 | 31141 | 34918085 |
Cerebral ischaemia | 26.93 | 16.72 | 17 | 7688 | 6305 | 34942921 |
Intestinal ischaemia | 26.02 | 16.72 | 18 | 7687 | 7776 | 34941450 |
Lung consolidation | 25.38 | 16.72 | 16 | 7689 | 5920 | 34943306 |
Mechanical ventilation | 25.00 | 16.72 | 11 | 7694 | 1959 | 34947267 |
Muscle atrophy | 24.49 | 16.72 | 17 | 7688 | 7387 | 34941839 |
Toxic skin eruption | 24.04 | 16.72 | 20 | 7685 | 11365 | 34937861 |
Drug ineffective | 24.00 | 16.72 | 40 | 7665 | 456711 | 34492515 |
Lung infiltration | 23.85 | 16.72 | 21 | 7684 | 12884 | 34936342 |
Chromaturia | 23.63 | 16.72 | 22 | 7683 | 14498 | 34934728 |
Eosinophilia | 23.59 | 16.72 | 29 | 7676 | 26193 | 34923033 |
Endotracheal intubation | 23.21 | 16.72 | 12 | 7693 | 3053 | 34946173 |
Death | 22.66 | 16.72 | 33 | 7672 | 398016 | 34551210 |
Meningitis aseptic | 22.64 | 16.72 | 12 | 7693 | 3212 | 34946014 |
Kounis syndrome | 22.42 | 16.72 | 11 | 7694 | 2507 | 34946719 |
Dermatitis exfoliative | 21.39 | 16.72 | 15 | 7690 | 6624 | 34942602 |
Bronchospasm | 20.91 | 16.72 | 18 | 7687 | 10713 | 34938513 |
Secretion discharge | 20.57 | 16.72 | 14 | 7691 | 5891 | 34943335 |
Pyrexia | 20.30 | 16.72 | 134 | 7571 | 332879 | 34616347 |
Atelectasis | 19.95 | 16.72 | 22 | 7683 | 17705 | 34931521 |
Aspartate aminotransferase increased | 19.62 | 16.72 | 45 | 7660 | 67738 | 34881488 |
Alanine aminotransferase increased | 19.49 | 16.72 | 50 | 7655 | 80765 | 34868461 |
Blood bilirubin increased | 19.12 | 16.72 | 32 | 7673 | 38264 | 34910962 |
Injury | 18.80 | 16.72 | 23 | 7682 | 20664 | 34928562 |
Mixed liver injury | 18.23 | 16.72 | 10 | 7695 | 2863 | 34946363 |
Gamma-glutamyltransferase increased | 18.16 | 16.72 | 27 | 7678 | 29204 | 34920022 |
Atrophic glossitis | 18.10 | 16.72 | 3 | 7702 | 9 | 34949217 |
Toxicity to various agents | 17.94 | 16.72 | 11 | 7694 | 200351 | 34748875 |
Liver injury | 17.68 | 16.72 | 19 | 7686 | 14859 | 34934367 |
Tachypnoea | 17.65 | 16.72 | 21 | 7684 | 18331 | 34930895 |
Erythema | 17.49 | 16.72 | 51 | 7654 | 88729 | 34860497 |
Hyperbilirubinaemia | 17.41 | 16.72 | 20 | 7685 | 16823 | 34932403 |
Product dose omission issue | 16.90 | 16.72 | 3 | 7702 | 119708 | 34829518 |
Aminoaciduria | 16.86 | 16.72 | 5 | 7700 | 285 | 34948941 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hepatocellular injury | 165.67 | 13.78 | 106 | 14829 | 47487 | 79681966 |
Cholestasis | 161.71 | 13.78 | 108 | 14827 | 52001 | 79677452 |
Hepatitis cholestatic | 124.91 | 13.78 | 58 | 14877 | 13794 | 79715659 |
Jaundice | 122.46 | 13.78 | 92 | 14843 | 53257 | 79676196 |
Drug reaction with eosinophilia and systemic symptoms | 79.97 | 13.78 | 78 | 14857 | 64166 | 79665287 |
Acute generalised exanthematous pustulosis | 76.81 | 13.78 | 45 | 14890 | 17209 | 79712244 |
Anaphylactic reaction | 72.81 | 13.78 | 84 | 14851 | 83659 | 79645794 |
Spinal muscular atrophy | 69.79 | 13.78 | 16 | 14919 | 387 | 79729066 |
Purpura | 69.16 | 13.78 | 44 | 14891 | 19483 | 79709970 |
Anaphylactic shock | 67.27 | 13.78 | 55 | 14880 | 35941 | 79693512 |
Toxic epidermal necrolysis | 64.80 | 13.78 | 59 | 14876 | 44522 | 79684931 |
Toxic skin eruption | 63.85 | 13.78 | 44 | 14891 | 22249 | 79707204 |
Motor neurone disease | 63.25 | 13.78 | 16 | 14919 | 592 | 79728861 |
Stoma closure | 57.45 | 13.78 | 13 | 14922 | 296 | 79729157 |
Pneumococcal sepsis | 55.36 | 13.78 | 18 | 14917 | 1644 | 79727809 |
Pruritus | 50.96 | 13.78 | 176 | 14759 | 394472 | 79334981 |
Blood alkaline phosphatase increased | 48.95 | 13.78 | 60 | 14875 | 63604 | 79665849 |
Rash maculo-papular | 48.30 | 13.78 | 56 | 14879 | 56022 | 79673431 |
Jaundice cholestatic | 46.49 | 13.78 | 28 | 14907 | 11256 | 79718197 |
Lymphadenectomy | 43.42 | 13.78 | 14 | 14921 | 1245 | 79728208 |
Lower respiratory tract infection bacterial | 42.89 | 13.78 | 13 | 14922 | 943 | 79728510 |
Nail dystrophy | 42.15 | 13.78 | 13 | 14922 | 1000 | 79728453 |
Drug hypersensitivity | 41.81 | 13.78 | 137 | 14798 | 298779 | 79430674 |
Chromaturia | 41.23 | 13.78 | 36 | 14899 | 25710 | 79703743 |
Gamma-glutamyltransferase increased | 41.17 | 13.78 | 51 | 14884 | 54629 | 79674824 |
Bronchial disorder | 41.05 | 13.78 | 16 | 14919 | 2473 | 79726980 |
Ischaemic cerebral infarction | 40.76 | 13.78 | 16 | 14919 | 2519 | 79726934 |
Stevens-Johnson syndrome | 40.42 | 13.78 | 43 | 14892 | 39123 | 79690330 |
Hepatic cytolysis | 39.58 | 13.78 | 36 | 14899 | 27115 | 79702338 |
Hepatitis | 38.82 | 13.78 | 50 | 14885 | 55677 | 79673776 |
Meningitis aseptic | 38.78 | 13.78 | 21 | 14914 | 6907 | 79722546 |
Aspartate aminotransferase increased | 38.37 | 13.78 | 82 | 14853 | 138559 | 79590894 |
Dermatitis exfoliative | 37.35 | 13.78 | 24 | 14911 | 10805 | 79718648 |
Injury | 36.93 | 13.78 | 58 | 14877 | 77438 | 79652015 |
Increased bronchial secretion | 36.56 | 13.78 | 16 | 14919 | 3311 | 79726142 |
Clostridium difficile colitis | 36.10 | 13.78 | 37 | 14898 | 32246 | 79697207 |
Axillary pain | 36.10 | 13.78 | 14 | 14921 | 2135 | 79727318 |
Alanine aminotransferase increased | 35.96 | 13.78 | 88 | 14847 | 162482 | 79566971 |
Peripheral swelling | 34.00 | 13.78 | 5 | 14930 | 269612 | 79459841 |
Off label use | 33.06 | 13.78 | 76 | 14859 | 907139 | 78822314 |
Respiratory tract infection bacterial | 33.01 | 13.78 | 13 | 14922 | 2064 | 79727389 |
Kounis syndrome | 32.70 | 13.78 | 16 | 14919 | 4266 | 79725187 |
Drug ineffective | 32.27 | 13.78 | 100 | 14835 | 1080813 | 78648640 |
Infusion related reaction | 32.18 | 13.78 | 3 | 14932 | 230234 | 79499219 |
Eosinophilia | 32.08 | 13.78 | 41 | 14894 | 45304 | 79684149 |
Mixed liver injury | 31.72 | 13.78 | 19 | 14916 | 7559 | 79721894 |
Sputum increased | 31.57 | 13.78 | 16 | 14919 | 4597 | 79724856 |
Resuscitation | 31.17 | 13.78 | 13 | 14922 | 2391 | 79727062 |
Pyrexia | 30.92 | 13.78 | 225 | 14710 | 678484 | 79050969 |
Bone erosion | 30.70 | 13.78 | 26 | 14909 | 17821 | 79711632 |
Bronchospasm | 30.57 | 13.78 | 30 | 14905 | 24829 | 79704624 |
Disease complication | 30.55 | 13.78 | 16 | 14919 | 4921 | 79724532 |
International normalised ratio increased | 29.29 | 13.78 | 55 | 14880 | 84666 | 79644787 |
Death | 29.24 | 13.78 | 38 | 14897 | 566476 | 79162977 |
Demyelination | 28.21 | 13.78 | 18 | 14917 | 8005 | 79721448 |
Liver injury | 27.84 | 13.78 | 43 | 14892 | 56571 | 79672882 |
Bone marrow eosinophilic leukocyte count increased | 27.78 | 13.78 | 5 | 14930 | 33 | 79729420 |
Bronchiectasis | 27.50 | 13.78 | 27 | 14908 | 22359 | 79707094 |
Nasopharyngitis | 27.19 | 13.78 | 7 | 14928 | 253874 | 79475579 |
Allergic hepatitis | 26.72 | 13.78 | 5 | 14930 | 42 | 79729411 |
Brain injury | 26.71 | 13.78 | 20 | 14915 | 11497 | 79717956 |
Thrombocytopenia | 26.45 | 13.78 | 109 | 14826 | 265150 | 79464303 |
Lung consolidation | 26.42 | 13.78 | 18 | 14917 | 8929 | 79720524 |
Product dose omission issue | 26.18 | 13.78 | 7 | 14928 | 247530 | 79481923 |
Chest X-ray abnormal | 26.03 | 13.78 | 17 | 14918 | 7866 | 79721587 |
Metabolic disorder | 26.02 | 13.78 | 18 | 14917 | 9152 | 79720301 |
Hepatitis acute | 25.42 | 13.78 | 22 | 14913 | 15520 | 79713933 |
Acute kidney injury | 25.25 | 13.78 | 175 | 14760 | 519229 | 79210224 |
Catheter site haemorrhage | 24.51 | 13.78 | 14 | 14921 | 5103 | 79724350 |
Scoliosis | 24.41 | 13.78 | 16 | 14919 | 7448 | 79722005 |
Intestinal ischaemia | 24.20 | 13.78 | 20 | 14915 | 13250 | 79716203 |
Blood bilirubin increased | 24.15 | 13.78 | 44 | 14891 | 66188 | 79663265 |
Circulatory collapse | 23.46 | 13.78 | 32 | 14903 | 37636 | 79691817 |
Mechanical ventilation | 23.14 | 13.78 | 11 | 14924 | 2753 | 79726700 |
Cerebral ischaemia | 22.81 | 13.78 | 18 | 14917 | 11177 | 79718276 |
Muscle atrophy | 22.75 | 13.78 | 18 | 14917 | 11214 | 79718239 |
Tachypnoea | 22.69 | 13.78 | 29 | 14906 | 32034 | 79697419 |
Cholecystitis chronic | 22.52 | 13.78 | 17 | 14918 | 9889 | 79719564 |
Agranulocytosis | 21.86 | 13.78 | 34 | 14901 | 44996 | 79684457 |
Neutropenia | 21.78 | 13.78 | 109 | 14826 | 287601 | 79441852 |
Drug-induced liver injury | 21.71 | 13.78 | 42 | 14893 | 66075 | 79663378 |
Atelectasis | 21.00 | 13.78 | 28 | 14907 | 32229 | 79697224 |
Rash | 20.95 | 13.78 | 182 | 14753 | 578176 | 79151277 |
Face oedema | 20.78 | 13.78 | 26 | 14909 | 28110 | 79701343 |
Endotracheal intubation | 20.24 | 13.78 | 12 | 14923 | 4685 | 79724768 |
Lung infiltration | 19.92 | 13.78 | 23 | 14912 | 22889 | 79706564 |
Joint swelling | 19.88 | 13.78 | 15 | 14920 | 288631 | 79440822 |
Contraindicated product administered | 19.67 | 13.78 | 3 | 14932 | 157535 | 79571918 |
Faeces pale | 19.51 | 13.78 | 10 | 14925 | 2940 | 79726513 |
Vascular purpura | 19.05 | 13.78 | 10 | 14925 | 3088 | 79726365 |
Arthropathy | 18.74 | 13.78 | 5 | 14930 | 177106 | 79552347 |
Cholangitis | 18.73 | 13.78 | 17 | 14918 | 12759 | 79716694 |
Motor dysfunction | 18.52 | 13.78 | 18 | 14917 | 14715 | 79714738 |
Rash scarlatiniform | 18.46 | 13.78 | 5 | 14930 | 242 | 79729211 |
Headache | 18.37 | 13.78 | 62 | 14873 | 653710 | 79075743 |
Toxicity to various agents | 18.13 | 13.78 | 32 | 14903 | 421508 | 79307945 |
Erythema | 17.89 | 13.78 | 86 | 14849 | 223204 | 79506249 |
Abdominal discomfort | 17.30 | 13.78 | 13 | 14922 | 250714 | 79478739 |
Blood pressure increased | 17.29 | 13.78 | 9 | 14926 | 211351 | 79518102 |
Rash morbilliform | 17.28 | 13.78 | 12 | 14923 | 6138 | 79723315 |
Cholestatic liver injury | 17.16 | 13.78 | 11 | 14924 | 4930 | 79724523 |
Dizziness | 16.86 | 13.78 | 47 | 14888 | 526394 | 79203059 |
Inflammation | 16.86 | 13.78 | 47 | 14888 | 93706 | 79635747 |
Cholelithiasis | 16.74 | 13.78 | 33 | 14902 | 52631 | 79676822 |
Appendicitis | 16.63 | 13.78 | 20 | 14915 | 20774 | 79708679 |
Hyperchlorhydria | 16.57 | 13.78 | 8 | 14927 | 2071 | 79727382 |
Odynophagia | 16.47 | 13.78 | 15 | 14920 | 11312 | 79718141 |
Emotional distress | 16.44 | 13.78 | 28 | 14907 | 39941 | 79689512 |
Linear IgA disease | 16.17 | 13.78 | 9 | 14926 | 3123 | 79726330 |
Aminoaciduria | 16.15 | 13.78 | 5 | 14930 | 389 | 79729064 |
Strawberry tongue | 16.05 | 13.78 | 3 | 14932 | 25 | 79729428 |
Weight increased | 16.00 | 13.78 | 17 | 14918 | 277369 | 79452084 |
Treatment failure | 15.92 | 13.78 | 6 | 14929 | 170480 | 79558973 |
Type I hypersensitivity | 15.79 | 13.78 | 10 | 14925 | 4388 | 79725065 |
Deep vein thrombosis | 15.60 | 13.78 | 54 | 14881 | 120865 | 79608588 |
Hyperbilirubinaemia | 15.53 | 13.78 | 21 | 14914 | 24497 | 79704956 |
Injection site pain | 15.05 | 13.78 | 3 | 14932 | 129835 | 79599618 |
Therapeutic product effect decreased | 14.92 | 13.78 | 6 | 14929 | 163857 | 79565596 |
Product use in unapproved indication | 14.83 | 13.78 | 15 | 14920 | 250344 | 79479109 |
Transaminases increased | 14.75 | 13.78 | 31 | 14904 | 51712 | 79677741 |
Atrophic glossitis | 14.70 | 13.78 | 3 | 14932 | 41 | 79729412 |
Veillonella infection | 14.26 | 13.78 | 3 | 14932 | 48 | 79729405 |
Hyperthermia malignant | 14.02 | 13.78 | 8 | 14927 | 2909 | 79726544 |
Pseudomembranous colitis | 13.97 | 13.78 | 10 | 14925 | 5364 | 79724089 |
Hyperthermia | 13.86 | 13.78 | 17 | 14918 | 18020 | 79711433 |
None
Source | Code | Description |
---|---|---|
FDA MoA | N0000000202 | beta Lactamase Inhibitors |
FDA EPC | N0000175930 | beta Lactamase Inhibitor |
CHEBI has role | CHEBI:35474 | anti-anxiety agents |
CHEBI has role | CHEBI:35625 | beta-lactamase inhibitors |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
CHEBI has role | CHEBI:33281 | antibiotics |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D065093 | beta-Lactamase Inhibitors |
MeSH PA | D004791 | Enzyme Inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Septicemia due to Escherichia coli | indication | 9323009 | |
Bacterial septicemia | indication | 10001005 | DOID:0040085 |
Haemophilus Influenzae Acute Otitis Media | indication | 19021002 | |
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Staphylococcal pneumonia | indication | 22754005 | |
Bacterial pneumonia | indication | 53084003 | DOID:874 |
Klebsiella cystitis | indication | 60867007 | |
Pneumonia due to Klebsiella pneumoniae | indication | 64479007 | |
Urinary tract infectious disease | indication | 68566005 | |
Haemophilus influenzae pneumonia | indication | 70036007 | |
Infection due to Escherichia coli | indication | 71057007 | |
Rhinoscleroma | indication | 72409005 | DOID:11336 |
Acute bacterial sinusitis | indication | 75498004 | |
Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
Pneumococcal pneumonia | indication | 233607000 | |
Escherichia coli urinary tract infection | indication | 301011002 | |
Bacterial urinary infection | indication | 312124009 | |
Infective otitis media | indication | 312218008 | |
Infection due to Staphylococcus aureus | indication | 406602003 | |
Osteomyelitis due to Staphylococcus aureus | indication | 428783003 | |
Pneumonia due to Staphylococcus aureus | indication | 441658007 | |
Sepsis due to Staphylococcus aureus | indication | 448417001 | |
Sepsis due to Pseudomonas | indication | 448813005 | |
Moraxella Catarrhalis Acute Otitis Media | indication | 703469002 | |
Bacteroides Endometritis | indication | ||
Pneumococcal Acute Otitis Media | indication | ||
Haemophilus Parainfluenzae Pneumonia | indication | ||
Pseudomonas Aeruginosa Urinary Tract Infection | indication | ||
Klebsiella Endometritis | indication | ||
Klebsiella Pneumoniae Peritonitis | indication | ||
Moraxella Catarrhalis Pneumonia | indication | ||
Staphylococcus Aureus Joint Infection | indication | ||
Staphylococcus Aureus Urinary Tract Infection | indication | ||
E. Coli Peritonitis | indication | ||
Enterobacter Endometritis | indication | ||
Bacteroides Peritonitis | indication | ||
Serratia Urinary Tract Infection | indication | ||
Citrobacter Urinary Tract Infection | indication | ||
Staphylococcus Endometritis | indication | ||
E. Coli Endometritis | indication | ||
Acute otitis media | off-label use | 3110003 | |
Pyrexia of unknown origin | off-label use | 7520000 | |
Chronic purulent otitis media | off-label use | 38394007 | DOID:14247 |
Cholangitis | off-label use | 82403002 | DOID:9446 |
Human bite - wound | off-label use | 262555007 | |
Chancroid | off-label use | 266143009 | DOID:13778 |
Diverticulitis of gastrointestinal tract | off-label use | 271366000 | |
Dog bite - wound | off-label use | 283734005 | |
Cat bite - wound | off-label use | 283782004 | |
Acute exacerbation of chronic bronchitis | off-label use | 425748003 | |
Diabetic Foot Infection | off-label use | ||
Pseudomonas Respiratory Tract Infection in Cystic Fibrosis | off-label use | ||
Obstruction of bile duct | contraindication | 30144000 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Infectious mononucleosis | contraindication | 271558008 | DOID:8568 |
Pseudomembranous enterocolitis | contraindication | 397683000 |
Species | Use | Relation |
---|---|---|
Dogs | Urinary tract infections caused by Escherichia coli | Indication |
Dogs | Skin and soft tissue infections caused by beta-lactamase producing Staphylococcus aureus | Indication |
Dogs | Skin and soft tissue infections caused by Staphylococcus spp | Indication |
Dogs | Skin and soft tissue infections caused by Streptococcus spp | Indication |
Dogs | Skin and soft tissue infections caused by Escherichia coli | Indication |
Dogs | Skin and soft tissue infections caused by Pasteurella spp | Indication |
Cats | Urinary tract infections caused by Escherichia coli | Indication |
Cats | Skin and soft tissue infections caused by beta-lactamase producing Staphylococcus aureus | Indication |
Cats | Skin and soft tissue infections caused by Staphylococcus spp | Indication |
Cats | Skin and soft tissue infections caused by Streptococcus spp | Indication |
Cats | Skin and soft tissue infections caused by Escherichia coli | Indication |
Cats | Skin and soft tissue infections caused by Pasteurella spp | Indication |
Cats | Periodontal infections due aerobic and anaerobic bacteria | Indication |
Product | Applicant | Ingredients |
---|---|---|
CLAVAMOX CHEWABLE Tablets, CLAVAMOX tablets | Zoetis Inc. | 2 |
Clavamox Drops | Zoetis Inc. | 2 |
Clavacillin | Dechra Veterinary Products LLC | 2 |
Amoxicillin and Clavulanate Potassium for Oral Suspension | Dechra Veterinary Products LLC | 2 |
Amoxicillin and Clavulanate Potassium Tablets | Cronus Pharma Specialities India Private Limited | 2 |
Amoxicillin and Clavulanate Potassium for Oral Suspension | Cronus Pharma Specialities India Private Limited | 2 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 3.07 | acidic |
pKa2 | 13.53 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Beta-lactamase TEM | Enzyme | INHIBITOR | IC50 | 10.19 | WOMBAT-PK | CHEMBL | |||
Beta-lactamase | Enzyme | MPC | 8.72 | WOMBAT-PK | |||||
Beta-lactamase | Enzyme | IC50 | 7.82 | CHEMBL | |||||
Beta-lactamase | Enzyme | IC50 | 4 | CHEMBL | |||||
Beta-lactamase SHV-1 | Enzyme | IC50 | 7.55 | CHEMBL | |||||
Beta-lactamase | Enzyme | Kd | 6.40 | CHEMBL | |||||
Beta-lactamase OXA-1 | Enzyme | IC50 | 5.49 | CHEMBL | |||||
Beta-lactamase | Enzyme | IC50 | 6.10 | CHEMBL | |||||
Beta-lactamase | Enzyme | IC50 | 8.05 | CHEMBL | |||||
Beta-lactamase | Enzyme | IC50 | 7.15 | CHEMBL | |||||
Beta-lactamase | Enzyme | IC50 | 7.07 | CHEMBL | |||||
Carbapenem-hydrolizing beta-lactamase SFC-1 | Enzyme | IC50 | 4.14 | CHEMBL | |||||
Carbepenem-hydrolyzing beta-lactamase KPC | Enzyme | Ki | 4.96 | CHEMBL | |||||
Beta-lactamase | Enzyme | IC50 | 7.17 | CHEMBL | |||||
Beta-lactamase | Enzyme | IC50 | 8.05 | CHEMBL | |||||
Beta-lactamase SHV-1 | Enzyme | IC50 | 6.77 | CHEMBL | |||||
Beta-lactamase | Enzyme | IC50 | 5.07 | CHEMBL | |||||
Beta-lactamase | Enzyme | IC50 | 5.76 | CHEMBL | |||||
Beta-lactamase | Enzyme | IC50 | 7.70 | CHEMBL | |||||
Class D beta-lactamase | Unclassified | IC50 | 5.70 | CHEMBL | |||||
Beta-lactamase | Enzyme | IC50 | 8 | CHEMBL | |||||
Beta-lactamase SHV-5 | Enzyme | Ki | 4.60 | CHEMBL | |||||
Beta-lactamase | Enzyme | IC50 | 7 | CHEMBL | |||||
Beta-lactamase | Enzyme | IC50 | 7 | CHEMBL | |||||
Beta-lactamase GES-13 | Enzyme | IC50 | 7 | CHEMBL | |||||
Beta-lactamase | Enzyme | IC50 | 7.44 | CHEMBL |
ID | Source |
---|---|
N0000005804 | NUI |
D02370 | KEGG_DRUG |
61177-45-5 | SECONDARY_CAS_RN |
21216 | RXNORM |
4018406 | VANDF |
4019680 | VANDF |
C0055860 | UMLSCUI |
CHEBI:48947 | CHEBI |
J01 | PDB_CHEM_ID |
CHEMBL777 | ChEMBL_ID |
DB00766 | DRUGBANK_ID |
CHEMBL1003 | ChEMBL_ID |
D019818 | MESH_DESCRIPTOR_UI |
5280980 | PUBCHEM_CID |
4948 | INN_ID |
11128 | IUPHAR_LIGAND_ID |
23521W1S24 | UNII |
4463 | MMSL |
d04405 | MMSL |
002808 | NDDF |
002809 | NDDF |
395938000 | SNOMEDCT_US |
395939008 | SNOMEDCT_US |
412318009 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2270 | TABLET, CHEWABLE | 28.50 mg | ORAL | ANDA | 27 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2270 | TABLET, CHEWABLE | 28.50 mg | ORAL | ANDA | 27 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2270 | TABLET, CHEWABLE | 28.50 mg | ORAL | ANDA | 27 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2272 | TABLET, CHEWABLE | 57 mg | ORAL | ANDA | 27 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2272 | TABLET, CHEWABLE | 57 mg | ORAL | ANDA | 27 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2272 | TABLET, CHEWABLE | 57 mg | ORAL | ANDA | 27 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2274 | TABLET, FILM COATED | 125 mg | ORAL | ANDA | 27 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2274 | TABLET, FILM COATED | 125 mg | ORAL | ANDA | 27 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2274 | TABLET, FILM COATED | 125 mg | ORAL | ANDA | 27 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2275 | TABLET, FILM COATED | 125 mg | ORAL | ANDA | 27 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2275 | TABLET, FILM COATED | 125 mg | ORAL | ANDA | 27 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2275 | TABLET, FILM COATED | 125 mg | ORAL | ANDA | 27 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2277 | POWDER, FOR SUSPENSION | 28.50 mg | ORAL | ANDA | 27 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2277 | POWDER, FOR SUSPENSION | 28.50 mg | ORAL | ANDA | 27 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2277 | POWDER, FOR SUSPENSION | 28.50 mg | ORAL | ANDA | 27 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2279 | POWDER, FOR SUSPENSION | 57 mg | ORAL | ANDA | 27 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2279 | POWDER, FOR SUSPENSION | 57 mg | ORAL | ANDA | 27 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2279 | POWDER, FOR SUSPENSION | 57 mg | ORAL | ANDA | 27 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-8675 | POWDER, FOR SUSPENSION | 42.90 mg | ORAL | ANDA | 27 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-8675 | POWDER, FOR SUSPENSION | 42.90 mg | ORAL | ANDA | 27 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-8675 | POWDER, FOR SUSPENSION | 42.90 mg | ORAL | ANDA | 27 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0143-9249 | TABLET | 125 mg | ORAL | ANDA | 29 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0143-9249 | TABLET | 125 mg | ORAL | ANDA | 29 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0143-9853 | SUSPENSION | 42.90 mg | ORAL | ANDA | 32 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0143-9853 | SUSPENSION | 42.90 mg | ORAL | ANDA | 32 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0143-9853 | SUSPENSION | 42.90 mg | ORAL | ANDA | 32 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0143-9981 | POWDER, FOR SUSPENSION | 28.50 mg | ORAL | ANDA | 30 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0143-9981 | POWDER, FOR SUSPENSION | 28.50 mg | ORAL | ANDA | 30 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0143-9982 | POWDER, FOR SUSPENSION | 57 mg | ORAL | ANDA | 30 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0143-9982 | POWDER, FOR SUSPENSION | 57 mg | ORAL | ANDA | 30 sections |