cisatracurium Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
neuromuscular blocking agents with rigid structure 661 96946-42-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cisatracurium besylate
  • cisatracurium besilate
  • cisatracurium
  • Molecular weight: 929.16
  • Formula: C53H72N2O12
  • CLOGP: 3.50
  • LIPINSKI: 2
  • HAC: 14
  • HDO: 0
  • TPSA: 126.44
  • ALOGS: -7.63
  • ROTB: 26

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 0 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 8.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.65 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.14 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 5.40 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.62 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.42 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 15, 1995 FDA ABBVIE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC M03AC11 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS
Other quaternary ammonium compounds
FDA PE N0000175732 Neuromuscular Nondepolarizing Blockade
FDA EPC N0000175720 Nondepolarizing Neuromuscular Blocker
MeSH PA D009465 Neuromuscular Agents
MeSH PA D009466 Neuromuscular Blocking Agents
MeSH PA D018373 Peripheral Nervous System Agents
CHEBI has role CHEBI:51371 muscle relaxant
CHEBI has role CHEBI:48878 nicotinic antagonist

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Muscle relaxation, function indication 11977004
General anesthesia indication 50697003
Skeletal Muscle Relaxation for Endotracheal Intubation indication
Disorder of lung contraindication 19829001 DOID:850
Myasthenia gravis contraindication 91637004 DOID:437
Disorder of electrolytes contraindication 237840007
Malignant hyperthermia contraindication 405501007

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Acetylcholine receptor Ion channel ANTAGONIST IC50 8 WOMBAT-PK CHEMBL

External reference:

IDSource
4020957 VUID
N0000148433 NUI
C0530105 UMLSCUI
D00759 KEGG_DRUG
108452005 SNOMEDCT_US
319864 RXNORM
372495006 SNOMEDCT_US
d03875 MMSL
4024019 VANDF
005186 NDDF
80YS8O1MBS UNII
7389 INN_ID
DB00565 DRUGBANK_ID
CHEMBL1200641 ChEMBL_ID
CHEBI:3721 CHEBI
CHEMBL1201248 ChEMBL_ID
62887 PUBCHEM_CID
C101584 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Nimbex HUMAN PRESCRIPTION DRUG LABEL 1 0074-4378 INJECTION 2 mg INTRAVENOUS NDA 17 sections
Nimbex HUMAN PRESCRIPTION DRUG LABEL 1 0074-4380 INJECTION 2 mg INTRAVENOUS NDA 17 sections
Nimbex HUMAN PRESCRIPTION DRUG LABEL 1 0074-4382 INJECTION 10 mg INTRAVENOUS NDA 17 sections
Cisatracurium Besylate HUMAN PRESCRIPTION DRUG LABEL 1 0409-1098 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 18 sections
Cisatracurium Besylate HUMAN PRESCRIPTION DRUG LABEL 1 0409-1103 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 18 sections
Cisatracurium Besylate HUMAN PRESCRIPTION DRUG LABEL 1 0409-1208 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 18 sections
Cisatracurium Besylate HUMAN PRESCRIPTION DRUG LABEL 1 0703-2033 INJECTION 10 mg INTRAVENOUS ANDA 17 sections
Cisatracurium Besylate HUMAN PRESCRIPTION DRUG LABEL 1 0703-2045 INJECTION 200 mg INTRAVENOUS ANDA 17 sections
Cisatracurium Besylate HUMAN PRESCRIPTION DRUG LABEL 1 0703-2056 INJECTION 20 mg INTRAVENOUS ANDA 17 sections
cisatracurium besylate HUMAN PRESCRIPTION DRUG LABEL 1 0781-3150 INJECTION 2 mg INTRAVENOUS ANDA 17 sections
cisatracurium besylate HUMAN PRESCRIPTION DRUG LABEL 1 0781-3152 INJECTION 2 mg INTRAVENOUS ANDA 17 sections
cisatracurium besylate HUMAN PRESCRIPTION DRUG LABEL 1 0781-3153 INJECTION 10 mg INTRAVENOUS ANDA 17 sections
cisatracurium besylate HUMAN PRESCRIPTION DRUG LABEL 1 0781-9037 INJECTION 2 mg INTRAVENOUS ANDA 17 sections
cisatracurium besylate HUMAN PRESCRIPTION DRUG LABEL 1 0781-9038 INJECTION 2 mg INTRAVENOUS ANDA 17 sections
cisatracurium besylate HUMAN PRESCRIPTION DRUG LABEL 1 0781-9039 INJECTION 10 mg INTRAVENOUS ANDA 17 sections
CISATRACURIUM BESYLATE HUMAN PRESCRIPTION DRUG LABEL 1 57884-3061 INJECTION 2 mg INTRAVENOUS ANDA 16 sections
CISATRACURIUM BESYLATE HUMAN PRESCRIPTION DRUG LABEL 1 57884-3062 INJECTION 2 mg INTRAVENOUS ANDA 16 sections
CISATRACURIUM BESYLATE HUMAN PRESCRIPTION DRUG LABEL 1 57884-3063 INJECTION 10 mg INTRAVENOUS ANDA 16 sections
Cisatracurium HUMAN PRESCRIPTION DRUG LABEL 1 63323-416 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 12 sections
Cisatracurium HUMAN PRESCRIPTION DRUG LABEL 1 63323-417 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 12 sections
Cisatracurium HUMAN PRESCRIPTION DRUG LABEL 1 63323-418 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 12 sections
Cisatracurium Besylate HUMAN PRESCRIPTION DRUG LABEL 1 70069-141 INJECTION 2 mg INTRAVENOUS ANDA 17 sections
Cisatracurium Besylate HUMAN PRESCRIPTION DRUG LABEL 1 70069-151 INJECTION 10 mg INTRAVENOUS ANDA 17 sections
Cisatracurium Besylate HUMAN PRESCRIPTION DRUG LABEL 1 70069-161 INJECTION 2 mg INTRAVENOUS ANDA 17 sections
cisatracurium besylate HUMAN PRESCRIPTION DRUG LABEL 1 70710-1532 INJECTION 2 mg INTRAVENOUS ANDA 17 sections
cisatracurium besylate HUMAN PRESCRIPTION DRUG LABEL 1 70710-1534 INJECTION 10 mg INTRAVENOUS ANDA 17 sections
Cisatracurium Besylate HUMAN PRESCRIPTION DRUG LABEL 1 71288-712 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 16 sections
Cisatracurium Besylate HUMAN PRESCRIPTION DRUG LABEL 1 71288-713 INJECTION, SOLUTION 200 mg INTRAVENOUS ANDA 16 sections
Cisatracurium Besylate HUMAN PRESCRIPTION DRUG LABEL 1 71288-714 INJECTION, SOLUTION 20 mg INTRAVENOUS ANDA 16 sections
cisatracurium besylate HUMAN PRESCRIPTION DRUG LABEL 1 72785-0008 INJECTION 2 mg INTRAVENOUS ANDA 17 sections