ciprofloxacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibacterials, nalidixic acid derivatives 659 85721-33-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ciprofloxacin
  • ciprofloxacin hydrochloride
  • ciprofloxacillin
  • ciprofloxacine
  • ciprofloxacin hydrochloride monohydrate
  • ciprofloxacin HCl
  • ciprofloxacin lactate
A broad-spectrum antimicrobial carboxyfluoroquinoline.
  • Molecular weight: 331.35
  • Formula: C17H18FN3O3
  • CLOGP: -0.47
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 72.88
  • ALOGS: -2.39
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 g O
0.80 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.15 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 65 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 34.49 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 8.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.70 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.80 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 22, 1987 FDA BAYER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1323.83 9.68 2311 127182 308376 63051153
Tendon pain 665.97 9.68 252 129241 3074 63356455
Tendonitis 536.27 9.68 389 129104 19226 63340303
Abortion spontaneous 419.02 9.68 499 128994 46696 63312833
Drug reaction with eosinophilia and systemic symptoms 372.31 9.68 400 129093 33436 63326093
Pemphigus 348.68 9.68 5 129488 183721 63175808
Hand deformity 304.04 9.68 4 129489 159453 63200076
Tendon disorder 285.89 9.68 167 129326 5676 63353853
Glossodynia 284.34 9.68 21 129472 178855 63180674
Drug interaction 278.46 9.68 1062 128431 228069 63131460
Tendon rupture 273.28 9.68 184 129309 8055 63351474
Pathogen resistance 254.16 9.68 160 129333 6238 63353291
Synovitis 251.51 9.68 40 129453 186878 63172651
Toxic epidermal necrolysis 229.96 9.68 271 129222 25063 63334466
Systemic lupus erythematosus 224.81 9.68 73 129420 208845 63150684
Anti-cyclic citrullinated peptide antibody positive 216.91 9.68 4 129489 116208 63243321
Tubulointerstitial nephritis 216.64 9.68 234 129259 19669 63339860
Rheumatoid arthritis 215.66 9.68 125 129368 253694 63105835
Pericarditis 207.50 9.68 16 129477 131563 63227966
Arthropathy 194.70 9.68 119 129374 234673 63124856
Acute kidney injury 193.19 9.68 1052 128441 262363 63097166
Clostridium difficile colitis 183.33 9.68 218 129275 20351 63339178
Contraindicated product administered 174.01 9.68 115 129378 217533 63141996
Drug ineffective 168.49 9.68 1347 128146 1043418 62316111
Alopecia 167.34 9.68 269 129224 337267 63022262
Therapeutic product effect decreased 162.81 9.68 96 129397 193091 63166438
Duodenal ulcer perforation 162.74 9.68 3 129490 87206 63272323
Clostridium difficile infection 155.30 9.68 244 129249 29678 63329851
Rheumatoid factor positive 153.22 9.68 4 129489 84402 63275127
Helicobacter infection 152.96 9.68 9 129484 92776 63266753
Stevens-Johnson syndrome 148.70 9.68 217 129276 24733 63334796
Wound 147.95 9.68 74 129419 163189 63196340
Joint swelling 130.16 9.68 298 129195 327368 63032161
Infusion related reaction 124.12 9.68 193 129300 245328 63114201
Discomfort 122.56 9.68 97 129396 167277 63192252
Drug intolerance 120.74 9.68 283 129210 308378 63051151
Tinnitus 114.76 9.68 236 129257 35392 63324137
Treatment failure 109.90 9.68 147 129346 198896 63160633
Muscle injury 108.74 9.68 6 129487 65339 63294190
Myalgia 101.09 9.68 576 128917 145953 63213576
Total lung capacity increased 97.38 9.68 60 129433 2250 63357279
Dysbiosis 97.34 9.68 44 129449 862 63358667
Folliculitis 96.91 9.68 14 129479 70303 63289226
Completed suicide 96.26 9.68 93 129400 145580 63213949
Anal fistula 96.05 9.68 70 129423 3481 63356048
Asthma-chronic obstructive pulmonary disease overlap syndrome 95.82 9.68 57 129436 2004 63357525
Psoriatic arthropathy 94.86 9.68 34 129459 91486 63268043
Tendon injury 90.84 9.68 54 129439 1896 63357633
Rash maculo-papular 89.74 9.68 200 129293 31696 63327833
Tendon discomfort 87.28 9.68 27 129466 168 63359361
Anxiety 87.23 9.68 749 128744 216792 63142737
Fall 85.98 9.68 460 129033 391874 62967655
Abdominal pain 84.67 9.68 943 128550 292513 63067016
Cholecystitis chronic 84.49 9.68 105 129388 10256 63349273
Female genital tract fistula 84.23 9.68 90 129403 7469 63352060
Dermatitis exfoliative 83.05 9.68 77 129416 5382 63354147
Fistula 82.64 9.68 104 129389 10289 63349240
Product use issue 82.37 9.68 207 129286 220313 63139216
Drug resistance 81.15 9.68 158 129335 22775 63336754
Early retirement 79.59 9.68 16 129477 4 63359525
Loss of employment 78.96 9.68 52 129441 2192 63357337
Swelling 78.28 9.68 293 129200 275085 63084444
Hepatic enzyme increased 76.27 9.68 189 129304 202139 63157390
Acute generalised exanthematous pustulosis 75.72 9.68 103 129390 10996 63348533
Abdominal discomfort 74.92 9.68 368 129125 320517 63039012
Panic attack 73.18 9.68 149 129344 22182 63337347
Skin candida 72.36 9.68 44 129449 1611 63357918
Death 72.36 9.68 457 129036 373924 62985605
Maternal exposure during pregnancy 72.18 9.68 220 129273 219842 63139687
Colitis 71.63 9.68 240 129253 48288 63311241
Peripheral swelling 71.08 9.68 290 129203 265652 63093877
Multiple organ dysfunction syndrome 68.68 9.68 263 129230 56489 63303040
Geotrichum infection 67.22 9.68 28 129465 446 63359083
Hip arthroplasty 66.80 9.68 9 129484 47637 63311892
Nasopharyngitis 66.24 9.68 280 129213 253977 63105552
Musculoskeletal injury 63.17 9.68 19 129474 106 63359423
Connective tissue disorder 62.97 9.68 38 129455 1372 63358157
Burning sensation 62.48 9.68 248 129245 54159 63305370
Disturbance in attention 61.89 9.68 195 129298 37994 63321535
Therapeutic product effect incomplete 60.59 9.68 101 129392 124955 63234574
Urinary tract infection 60.43 9.68 814 128679 263870 63095659
Impaired healing 59.38 9.68 73 129420 102469 63257060
Joint noise 59.31 9.68 58 129435 4334 63355195
Ill-defined disorder 57.79 9.68 49 129444 81706 63277823
Febrile neutropenia 57.35 9.68 426 129067 118023 63241506
Trimethylaminuria 57.09 9.68 19 129474 154 63359375
Paraesthesia 56.98 9.68 529 128964 156437 63203092
Intentional overdose 56.77 9.68 41 129452 74111 63285418
Frequent bowel movements 56.68 9.68 137 129356 22885 63336644
Injection site pain 56.48 9.68 112 129381 129688 63229841
Type 2 diabetes mellitus 56.25 9.68 30 129463 63838 63295691
Pyrexia 55.66 9.68 1303 128190 469175 62890354
Pseudomembranous colitis 55.47 9.68 48 129445 3064 63356465
Vaginal flatulence 55.10 9.68 49 129444 3244 63356285
Anal abscess 54.90 9.68 57 129436 4575 63354954
Neuropathy peripheral 54.57 9.68 408 129085 113259 63246270
Eosinophilia 54.52 9.68 134 129359 22622 63336907
Diarrhoea 54.00 9.68 1871 127622 713495 62646034
Nasal polyps 53.79 9.68 64 129429 5975 63353554
Renal tubular necrosis 53.67 9.68 91 129402 11787 63347742
Torsade de pointes 53.48 9.68 97 129396 13254 63346275
Segmental diverticular colitis 53.03 9.68 18 129475 156 63359373
Nephritis allergic 52.37 9.68 19 129474 204 63359325
Pedal pulse abnormal 52.24 9.68 18 129475 164 63359365
Chronic kidney disease 52.18 9.68 207 129286 45191 63314338
Diverticulitis 51.76 9.68 188 129305 39369 63320160
Vulvovaginal burning sensation 51.29 9.68 39 129454 2070 63357459
Device expulsion 50.40 9.68 6 129487 34916 63324613
Weight increased 49.48 9.68 320 129173 260472 63099057
Pseudomonas infection 49.48 9.68 85 129408 11128 63348401
Oesophageal spasm 49.36 9.68 45 129448 3078 63356451
Hallucination 49.22 9.68 232 129261 54585 63304944
Infective pulmonary exacerbation of cystic fibrosis 47.27 9.68 73 129420 8744 63350785
Blood cholesterol increased 46.42 9.68 75 129418 93957 63265572
Proctitis 45.75 9.68 56 129437 5385 63354144
Neutropenia 44.44 9.68 549 128944 174456 63185073
Nervous system disorder 44.42 9.68 110 129383 18656 63340873
Mucosal inflammation 43.89 9.68 201 129292 46727 63312802
Emotional distress 43.70 9.68 156 129337 32393 63327136
Therapeutic response decreased 43.33 9.68 37 129456 61488 63298041
Calcium ionised decreased 42.97 9.68 18 129475 291 63359238
Hallucinations, mixed 42.72 9.68 51 129442 4778 63354751
Thrombocytopenia 42.71 9.68 484 129009 150673 63208856
Injection site erythema 42.33 9.68 65 129428 83109 63276420
Osteoporosis 42.22 9.68 33 129460 57305 63302224
Abscess 41.91 9.68 100 129393 16568 63342961
Intentional product use issue 41.79 9.68 128 129365 127764 63231765
Cholelithiasis 41.72 9.68 189 129304 43736 63315793
Injection site reaction 41.45 9.68 35 129458 58489 63301040
Food intolerance 41.37 9.68 42 129451 3283 63356246
Product dose omission issue 41.20 9.68 294 129199 234019 63125510
Sarcoidosis 41.07 9.68 61 129432 7061 63352468
Cystitis 39.75 9.68 219 129274 54772 63304757
Mobility decreased 39.07 9.68 122 129371 121037 63238492
Nasal oedema 38.91 9.68 29 129464 1493 63358036
Muscle atrophy 38.79 9.68 59 129434 6974 63352555
Lymphoedema 38.29 9.68 78 129415 11614 63347915
Pancytopenia 37.87 9.68 332 129161 96601 63262928
Sepsis 37.86 9.68 478 129015 152645 63206884
Oesophageal pain 37.64 9.68 42 129451 3659 63355870
Pouchitis 37.34 9.68 19 129474 488 63359041
Abdominal pain lower 37.01 9.68 126 129367 25552 63333977
Aspergillus infection 36.56 9.68 62 129431 8031 63351498
Knee arthroplasty 36.49 9.68 34 129459 54172 63305357
Toxic skin eruption 36.47 9.68 81 129412 12804 63346725
Radiculopathy 36.33 9.68 64 129429 8547 63350982
Pulmonary pain 36.17 9.68 40 129453 3450 63356079
Stomatitis 35.94 9.68 153 129340 138572 63220957
Rhinitis allergic 35.79 9.68 76 129417 11651 63347878
Impaired work ability 35.77 9.68 97 129396 17378 63342151
Fatigue 35.68 9.68 1466 128027 886562 62472967
Flank pain 35.53 9.68 93 129400 16317 63343212
Clostridium test positive 35.46 9.68 38 129455 3163 63356366
Abnormal palmar/plantar creases 35.38 9.68 10 129483 43 63359486
Sinusitis 35.33 9.68 294 129199 226359 63133170
Factor V deficiency 35.22 9.68 11 129482 71 63359458
Lividity 35.12 9.68 15 129478 255 63359274
Procedural anxiety 34.88 9.68 21 129472 755 63358774
Prescribed overdose 34.85 9.68 13 129480 34140 63325389
Erythema 34.67 9.68 527 128966 175224 63184305
Psoriasis 34.51 9.68 79 129414 86878 63272651
Grip strength decreased 34.31 9.68 3 129490 22284 63337245
Musculoskeletal stiffness 34.25 9.68 228 129265 184390 63175139
Irritable bowel syndrome 34.24 9.68 73 129420 82339 63277190
Pyelonephritis 33.74 9.68 96 129397 17682 63341847
Thermal burn 33.74 9.68 51 129442 5995 63353534
Crystal nephropathy 33.69 9.68 22 129471 914 63358615
Ectropion 33.33 9.68 13 129480 173 63359356
Malignant neoplasm progression 33.08 9.68 74 129419 82047 63277482
Mitochondrial cytopathy 33.05 9.68 14 129479 233 63359296
Megacolon 33.05 9.68 29 129464 1886 63357643
Cytokine release syndrome 32.93 9.68 83 129410 14231 63345298
Drug abuse 32.91 9.68 61 129432 72457 63287072
Klebsiella infection 32.75 9.68 61 129432 8505 63351024
Suicide attempt 32.57 9.68 46 129447 60872 63298657
Adverse event 32.31 9.68 55 129438 67504 63292025
Excessive eye blinking 31.86 9.68 24 129469 1256 63358273
Hepatitis cholestatic 31.48 9.68 53 129440 6825 63352704
Live birth 31.21 9.68 7 129486 25623 63333906
Gastroenteritis pseudomonas 31.18 9.68 6 129487 0 63359529
Collagen disorder 31.16 9.68 13 129480 208 63359321
Pulmonary eosinophilia 31.11 9.68 15 129478 342 63359187
Vaginal discharge 30.88 9.68 62 129431 9136 63350393
Hyperacusis 30.60 9.68 29 129464 2084 63357445
Fistula discharge 30.60 9.68 22 129471 1071 63358458
Bronchiectasis 30.48 9.68 87 129406 16055 63343474
Factor V inhibition 30.47 9.68 12 129481 164 63359365
Haematochezia 30.25 9.68 200 129293 53344 63306185
Oliguria 30.14 9.68 61 129432 9040 63350489
Pregnancy 30.02 9.68 19 129474 36817 63322712
Candida infection 29.98 9.68 126 129367 28225 63331304
Anal fissure 29.96 9.68 41 129452 4402 63355127
Anorectal ulcer 29.95 9.68 9 129484 50 63359479
Injection site bruising 29.76 9.68 25 129468 41885 63317644
Non-consummation 29.51 9.68 9 129484 53 63359476
Fungaemia 29.26 9.68 30 129463 2373 63357156
Pain 29.20 9.68 1225 128268 739403 62620126
Potentiating drug interaction 29.07 9.68 40 129453 4316 63355213
Mineral deficiency 29.06 9.68 7 129486 13 63359516
Muscle twitching 28.78 9.68 97 129396 19571 63339958
Exercise tolerance decreased 28.75 9.68 45 129448 5452 63354077
Accidental exposure to product 28.70 9.68 10 129483 27395 63332134
Injection site swelling 28.45 9.68 33 129460 47539 63311990
Coma 28.45 9.68 55 129438 64309 63295220
Hypersensitivity 28.36 9.68 423 129070 292262 63067267
Depersonalisation/derealisation disorder 28.25 9.68 23 129470 1349 63358180
Biliary dyskinesia 27.81 9.68 31 129462 2698 63356831
Therapy non-responder 27.72 9.68 72 129421 75829 63283700
Bacterial colitis 27.59 9.68 9 129484 68 63359461
Muscle contractions involuntary 27.57 9.68 29 129464 2363 63357166
Photosensitivity reaction 27.52 9.68 80 129413 14914 63344615
Feeding intolerance 27.39 9.68 18 129475 756 63358773
COVID-19 27.33 9.68 128 129365 112975 63246554
Paraesthesia oral 27.32 9.68 94 129399 19162 63340367
Injection site pruritus 27.31 9.68 31 129462 45085 63314444
Fat tissue decreased 27.23 9.68 7 129486 19 63359510
Weight bearing difficulty 27.18 9.68 30 129463 2582 63356947
Linear IgA disease 27.12 9.68 23 129470 1428 63358101
Amyloid arthropathy 26.86 9.68 16 129477 564 63358965
Neutropenic sepsis 26.69 9.68 84 129409 16354 63343175
Vulvovaginal pruritus 26.66 9.68 33 129460 3210 63356319
Vomiting 26.54 9.68 1395 128098 558222 62801307
Moraxella test positive 26.48 9.68 7 129486 22 63359507
Off label use 26.47 9.68 1116 128377 673346 62686183
Basal cell carcinoma 26.38 9.68 12 129481 27979 63331550
Cystic fibrosis 26.23 9.68 33 129460 3263 63356266
Multiple sclerosis relapse 25.52 9.68 37 129456 48441 63311088
Botulism 25.44 9.68 11 129482 193 63359336
Injection site hyperaesthesia 25.43 9.68 8 129485 53 63359476
Breast cancer 25.40 9.68 37 129456 48346 63311183
Acinetobacter infection 25.39 9.68 23 129470 1560 63357969
Gastrointestinal disorder 25.39 9.68 160 129333 131079 63228450
Rectal abscess 25.35 9.68 21 129472 1262 63358267
Fixed eruption 25.00 9.68 20 129473 1144 63358385
Acute hepatic failure 24.74 9.68 88 129405 18239 63341290
Rectal tube insertion 24.62 9.68 6 129487 12 63359517
Phlebitis 24.61 9.68 47 129446 6677 63352852
Cross sensitivity reaction 24.54 9.68 26 129467 2136 63357393
Staphylococcal infection 24.47 9.68 156 129337 41100 63318429
Nerve injury 24.28 9.68 59 129434 9887 63349642
Blood creatinine increased 24.22 9.68 280 129213 87564 63271965
Hepatitis infectious mononucleosis 23.91 9.68 9 129484 108 63359421
Myopathy 23.79 9.68 63 129430 11128 63348401
Rotator cuff syndrome 23.79 9.68 71 129422 13431 63346098
Sciatica 23.73 9.68 21 129472 34303 63325226
Toxicity to various agents 23.72 9.68 358 129135 246892 63112637
Condition aggravated 23.64 9.68 632 128861 401585 62957944
Septic shock 23.37 9.68 223 129270 66406 63293123
Cardio-respiratory arrest 23.36 9.68 55 129438 59904 63299625
Gastroenteritis staphylococcal 23.30 9.68 8 129485 72 63359457
Rhinalgia 23.26 9.68 22 129471 1577 63357952
Foot deformity 23.21 9.68 14 129479 27839 63331690
Bladder pain 23.14 9.68 26 129467 2282 63357247
Oral candidiasis 23.08 9.68 100 129393 22698 63336831
Infrequent bowel movements 23.04 9.68 20 129473 1282 63358247
Femur fracture 22.85 9.68 31 129462 41725 63317804
Diaphragmatic rupture 22.81 9.68 11 129482 251 63359278
Idiopathic intracranial hypertension 22.78 9.68 29 129464 2902 63356627
Diabetes mellitus 22.71 9.68 50 129443 55760 63303769
Incorrect route of product administration 22.59 9.68 14 129479 27438 63332091
Respiratory tract oedema 22.58 9.68 14 129479 531 63358998
Tendon necrosis 22.53 9.68 5 129488 5 63359524
Epicondylitis 22.43 9.68 25 129468 2175 63357354
Cardiac murmur 22.39 9.68 73 129420 14479 63345050
Chemical burns of eye 22.38 9.68 8 129485 82 63359447
Colitis ulcerative 22.38 9.68 109 129384 25982 63333547
Bone marrow granuloma 22.20 9.68 6 129487 21 63359508
Myoclonus 22.11 9.68 77 129416 15791 63343738
Renal injury 21.99 9.68 55 129438 9384 63350145
Meningitis candida 21.56 9.68 7 129486 52 63359477
Swelling face 21.55 9.68 211 129282 63264 63296265
Product contamination microbial 21.53 9.68 10 129483 209 63359320
Dermatitis bullous 21.34 9.68 51 129442 8457 63351072
Road traffic accident 21.28 9.68 26 129467 36606 63322923
Arthritis 21.06 9.68 144 129349 115777 63243752
Acute febrile neutrophilic dermatosis 20.90 9.68 28 129465 2946 63356583
Renal vein compression 20.79 9.68 4 129489 0 63359529
Neurotransmitter level altered 20.79 9.68 4 129489 0 63359529
Tendon laxity 20.79 9.68 4 129489 0 63359529
Prescribed underdose 20.72 9.68 18 129475 29671 63329858
Enterococcal infection 20.72 9.68 48 129445 7800 63351729
Confabulation 20.72 9.68 11 129482 309 63359220
C-reactive protein abnormal 20.71 9.68 39 129454 46057 63313472
Leukocytosis 20.59 9.68 106 129387 25829 63333700
Cholestatic liver injury 20.56 9.68 26 129467 2584 63356945
Hypomania 20.46 9.68 42 129451 6288 63353241
Muscular weakness 20.43 9.68 357 129136 121996 63237533
Swollen tongue 20.27 9.68 131 129362 34669 63324860
Osteoarthritis 20.15 9.68 113 129380 95230 63264299
Osteochondrosis 20.13 9.68 19 129474 1358 63358171
Intestinal dilatation 20.07 9.68 21 129472 1701 63357828
Adverse drug reaction 19.98 9.68 89 129404 79625 63279904
Palpitations 19.90 9.68 332 129161 112438 63247091
Head injury 19.87 9.68 16 129477 27380 63332149
Tonsillar haemorrhage 19.86 9.68 10 129483 251 63359278
Gallbladder rupture 19.84 9.68 12 129481 435 63359094
Vitreous floaters 19.77 9.68 40 129453 5926 63353603
Hepatic steatosis 19.74 9.68 113 129380 28656 63330873
Medical device site pain 19.65 9.68 9 129484 182 63359347
Single functional kidney 19.62 9.68 11 129482 345 63359184
Vaccination site reaction 19.58 9.68 8 129485 121 63359408
Hypercreatininaemia 19.53 9.68 13 129480 558 63358971
Enterocolonic fistula 19.44 9.68 6 129487 37 63359492
Diabetic macroangiopathy 19.34 9.68 8 129485 125 63359404
Activated partial thromboplastin time prolonged 19.13 9.68 43 129450 6850 63352679
Restlessness 19.12 9.68 114 129379 29339 63330190
Product administration error 19.02 9.68 11 129482 22386 63337143
Contusion 18.93 9.68 205 129288 149839 63209690
Arrhythmia 18.91 9.68 138 129355 38002 63321527
Long QT syndrome 18.78 9.68 28 129465 3251 63356278
Escherichia infection 18.74 9.68 63 129430 12691 63346838
Muscle tightness 18.58 9.68 60 129433 11840 63347689
Drug-induced liver injury 18.51 9.68 143 129350 40079 63319450
Mouth ulceration 18.51 9.68 123 129370 32861 63326668
Jaundice cholestatic 18.47 9.68 44 129449 7280 63352249
Immune effector cell-associated neurotoxicity syndrome 18.44 9.68 23 129470 2254 63357275
Escherichia urinary tract infection 18.39 9.68 60 129433 11902 63347627
Bacteriuria 18.28 9.68 16 129477 1037 63358492
Product quality issue 18.27 9.68 28 129465 35837 63323692
Product substitution issue 18.25 9.68 5 129488 15991 63343538
Hypotony of eye 18.12 9.68 8 129485 148 63359381
Sphingomonas paucimobilis infection 18.10 9.68 6 129487 48 63359481
Infusion site streaking 18.07 9.68 12 129481 513 63359016
Enterocutaneous fistula 18.03 9.68 18 129475 1379 63358150
Roseola 18.02 9.68 4 129489 4 63359525
Sensory processing disorder 18.02 9.68 4 129489 4 63359525
Polyneuropathy 17.96 9.68 68 129425 14521 63345008
Neuralgia 17.90 9.68 102 129391 25824 63333705
Red blood cell sedimentation rate abnormal 17.85 9.68 9 129484 19773 63339756
Heart rate decreased 17.76 9.68 156 129337 45404 63314125
Anhedonia 17.74 9.68 56 129437 10918 63348611
Blood bilirubin increased 17.63 9.68 133 129360 37007 63322522
Extremity necrosis 17.61 9.68 19 129474 1594 63357935
Chills 17.58 9.68 327 129166 113051 63246478
Vulvovaginal swelling 17.54 9.68 12 129481 539 63358990
Bladder trabeculation 17.48 9.68 6 129487 54 63359475
Device related infection 17.46 9.68 94 129399 23298 63336231
May-Thurner syndrome 17.42 9.68 5 129488 23 63359506
Lip dry 17.34 9.68 5 129488 15465 63344064
Skin oedema 17.33 9.68 15 129478 958 63358571
Enterovesical fistula 17.31 9.68 12 129481 551 63358978
Limb immobilisation 17.28 9.68 6 129487 56 63359473
Product deposit 17.28 9.68 9 129484 243 63359286
Seroconversion test positive 17.25 9.68 5 129488 24 63359505
Faecal volume decreased 17.15 9.68 8 129485 169 63359360
Gastrointestinal scarring 17.01 9.68 10 129483 344 63359185
Bursitis 16.94 9.68 31 129462 37010 63322519
Blister 16.93 9.68 176 129317 129638 63229891
Fungal infection 16.92 9.68 131 129362 36743 63322786
Henoch-Schonlein purpura 16.91 9.68 16 129477 1147 63358382
Injection site warmth 16.87 9.68 5 129488 15190 63344339
Neutrophilic dermatosis 16.85 9.68 8 129485 176 63359353
Liver injury 16.76 9.68 65 129428 60455 63299074
Herpes zoster 16.74 9.68 99 129394 82363 63277166
Bulimia nervosa 16.72 9.68 11 129482 463 63359066
Vanishing bile duct syndrome 16.63 9.68 13 129480 719 63358810
Skin injury 16.36 9.68 19 129474 1729 63357800
Loss of personal independence in daily activities 16.15 9.68 124 129369 97166 63262363
Injury 16.15 9.68 224 129269 73023 63286506
Haematoma 16.14 9.68 124 129369 34696 63324833
Staphylococcal scalded skin syndrome 16.13 9.68 7 129486 124 63359405
Symmetrical drug-related intertriginous and flexural exanthema 16.10 9.68 11 129482 493 63359036
Cholecystitis acute 16.06 9.68 45 129448 8215 63351314
Dysphonia 16.03 9.68 158 129335 47456 63312073
Nerve degeneration 16.02 9.68 6 129487 71 63359458
Intrauterine infection 15.98 9.68 7 129486 127 63359402
Eczema asteatotic 15.92 9.68 9 129484 287 63359242
Corneal deposits 15.86 9.68 9 129484 289 63359240
Rhabdomyolysis 15.86 9.68 148 129345 43803 63315726
Injection site streaking 15.78 9.68 5 129488 34 63359495
Factor XIII Inhibition 15.78 9.68 5 129488 34 63359495
Renal failure 15.78 9.68 332 129161 117320 63242209
Recall phenomenon 15.76 9.68 12 129481 638 63358891
Purple glove syndrome 15.74 9.68 8 129485 205 63359324
Burnout syndrome 15.70 9.68 8 129485 206 63359323
Infective aneurysm 15.67 9.68 10 129483 399 63359130
Face oedema 15.62 9.68 82 129411 20130 63339399
Eyelid oedema 15.61 9.68 52 129441 10427 63349102
Injection site joint erythema 15.59 9.68 3 129490 0 63359529
Hypertension 15.58 9.68 442 129051 278861 63080668
Dysuria 15.56 9.68 120 129373 33618 63325911
Type IV hypersensitivity reaction 15.54 9.68 24 129469 2874 63356655
Hyperchlorhydria 15.54 9.68 19 129474 1825 63357704
Persistent corneal epithelial defect 15.52 9.68 4 129489 11 63359518
Post infection glomerulonephritis 15.52 9.68 4 129489 11 63359518
Sleep disorder due to a general medical condition 15.52 9.68 3 129490 12185 63347344
Rash pustular 15.49 9.68 41 129452 7241 63352288
Spinal fracture 15.48 9.68 9 129484 18262 63341267
Encephalopathy 15.45 9.68 133 129360 38487 63321042
Ballismus 15.45 9.68 7 129486 138 63359391
Facet joint syndrome 15.43 9.68 3 129490 12135 63347394
Haematuria 15.33 9.68 107 129386 29050 63330479
Haemorrhagic vasculitis 15.30 9.68 6 129487 81 63359448
Paranasal sinus discomfort 15.30 9.68 30 129463 4346 63355183
Toxic neuropathy 15.26 9.68 10 129483 418 63359111
Hepatic cytolysis 15.16 9.68 67 129426 15340 63344189
Tongue geographic 15.11 9.68 6 129487 84 63359445
Nephropathy toxic 14.99 9.68 48 129445 9431 63350098
Haemolytic anaemia 14.87 9.68 50 129443 10075 63349454
Device malfunction 14.84 9.68 9 129484 17848 63341681
Colonic abscess 14.82 9.68 14 129479 1002 63358527
Hypercholesterolaemia 14.81 9.68 13 129480 21321 63338208
Carbohydrate antigen 15-3 14.79 9.68 6 129487 89 63359440
Cerebrovascular accident 14.68 9.68 145 129348 107879 63251650
Histamine intolerance 14.66 9.68 5 129488 44 63359485
Vaginal infection 14.66 9.68 41 129452 7477 63352052
Proctalgia 14.65 9.68 36 129457 6074 63353455
Carcinoembryonic antigen 14.61 9.68 6 129487 92 63359437
Deficiency of bile secretion 14.59 9.68 4 129489 15 63359514
Plantar fasciitis 14.58 9.68 27 129466 3748 63355781
Electrolyte imbalance 14.53 9.68 80 129413 19996 63339533
Skin test positive 14.50 9.68 12 129481 720 63358809
Dermatitis exfoliative generalised 14.42 9.68 27 129466 3780 63355749
Poisoning 14.34 9.68 5 129488 13695 63345834
Flushing 14.28 9.68 92 129401 74995 63284534
Aortic rupture 14.27 9.68 6 129487 98 63359431
Drug level below therapeutic 14.23 9.68 31 129462 4835 63354694
Bone density decreased 14.19 9.68 6 129487 14606 63344923
Walking disability 14.18 9.68 16 129477 1411 63358118
Intentional self-injury 14.12 9.68 19 129474 25668 63333861
Breast cancer female 14.11 9.68 5 129488 13554 63345975
Vascular access site pain 14.05 9.68 6 129487 102 63359427
Malignant melanoma 14.03 9.68 3 129490 11353 63348176
Visual snow syndrome 14.01 9.68 5 129488 51 63359478
Herpes simplex colitis 14.01 9.68 4 129489 18 63359511
Tuberculosis gastrointestinal 14.00 9.68 9 129484 364 63359165
Drug ineffective for unapproved indication 13.99 9.68 118 129375 33945 63325584
Acid base balance abnormal 13.99 9.68 8 129485 261 63359268
Depressed level of consciousness 13.98 9.68 72 129421 62006 63297523
Lower respiratory tract infection 13.93 9.68 188 129305 132119 63227410
Hyperpathia 13.83 9.68 4 129489 19 63359510
Tremor 13.69 9.68 360 129133 131879 63227650
Chronic fatigue syndrome 13.69 9.68 14 129479 1104 63358425
Anal paraesthesia 13.66 9.68 4 129489 20 63359509
Genital paraesthesia 13.66 9.68 4 129489 20 63359509
Burning mouth syndrome 13.66 9.68 10 129483 501 63359028
Visual impairment 13.59 9.68 245 129248 84201 63275328
Enterobiasis 13.59 9.68 5 129488 56 63359473
Foetal exposure during pregnancy 13.53 9.68 28 129465 31934 63327595
Intentional product misuse 13.53 9.68 71 129422 60846 63298683
Iatrogenic infection 13.52 9.68 3 129490 3 63359526
Electrocardiogram QT prolonged 13.51 9.68 183 129310 59347 63300182
Abdominal tenderness 13.51 9.68 42 129451 8124 63351405
Hypoglossal nerve paresis 13.49 9.68 6 129487 113 63359416
Clostridium colitis 13.42 9.68 18 129475 1896 63357633
Iatrogenic injury 13.37 9.68 12 129481 804 63358725
Portal fibrosis 13.35 9.68 8 129485 285 63359244
Abdominal pain upper 13.29 9.68 531 128962 205913 63153616
Joint range of motion decreased 13.24 9.68 29 129464 32399 63327130
Pulmonary arterial hypertension 13.14 9.68 16 129477 22561 63336968
Anorectal disorder 13.11 9.68 17 129476 1732 63357797
Sensory disturbance 13.11 9.68 59 129434 13613 63345916
Documented hypersensitivity to administered product 13.08 9.68 10 129483 535 63358994
Ototoxicity 13.07 9.68 15 129478 1347 63358182
Angiopathy 13.05 9.68 29 129464 4584 63354945
Thrombotic thrombocytopenic purpura 13.05 9.68 26 129467 3810 63355719
Neutropenic infection 13.03 9.68 15 129478 1352 63358177
Increased bronchial secretion 12.98 9.68 17 129476 1749 63357780
Pulmonary hypertension 12.96 9.68 36 129457 37087 63322442
Cardiovascular disorder 12.88 9.68 53 129440 11759 63347770
Self-injurious ideation 12.85 9.68 21 129472 2638 63356891
Muscle rupture 12.78 9.68 20 129473 2423 63357106
Metastases to kidney 12.71 9.68 7 129486 212 63359317
Diarrhoea haemorrhagic 12.71 9.68 44 129449 8998 63350531
Ligament disorder 12.65 9.68 9 129484 431 63359098
Cholestasis 12.64 9.68 103 129390 29331 63330198
Osteonecrosis 12.64 9.68 19 129474 24511 63335018
Fear of death 12.62 9.68 13 129480 1034 63358495
Myelosuppression 12.57 9.68 18 129475 23685 63335844
Refractory anaemia with an excess of blasts 12.52 9.68 9 129484 438 63359091
Fasciitis 12.50 9.68 10 129483 572 63358957
Bacteraemia 12.47 9.68 69 129424 17279 63342250
Peripheral nerve injury 12.45 9.68 9 129484 442 63359087
Drug level decreased 12.43 9.68 40 129453 7879 63351650
Vulvovaginal pain 12.42 9.68 21 129472 2714 63356815
Blood creatine increased 12.39 9.68 32 129461 5569 63353960
Deafness bilateral 12.38 9.68 15 129478 1427 63358102
Vaginal abscess 12.38 9.68 9 129484 446 63359083
Leukopenia 12.36 9.68 224 129269 77066 63282463
Systemic inflammatory response syndrome 12.31 9.68 32 129461 5589 63353940
Somatic dysfunction 12.31 9.68 3 129490 6 63359523
Norovirus test positive 12.28 9.68 7 129486 227 63359302
Productive cough 12.24 9.68 189 129304 63019 63296510
Toxic leukoencephalopathy 12.22 9.68 11 129482 740 63358789
Immunodeficiency 12.16 9.68 14 129479 20240 63339289
Large intestinal obstruction 12.15 9.68 19 129474 2300 63357229
Transmission of an infectious agent via product 12.13 9.68 6 129487 145 63359384
Gastric disorder 12.09 9.68 123 129370 37246 63322283
Acute myocardial infarction 12.09 9.68 30 129463 32094 63327435
Liver function test increased 12.07 9.68 31 129462 32780 63326749
Mitochondrial enzyme deficiency 12.07 9.68 4 129489 32 63359497
Gastrointestinal infection 12.04 9.68 44 129449 9237 63350292
Adjustment disorder with depressed mood 12.00 9.68 3 129490 10201 63349328
Chronic sinusitis 12.00 9.68 55 129438 12788 63346741
Tubulointerstitial nephritis and uveitis syndrome 11.98 9.68 7 129486 238 63359291
Diarrhoea infectious 11.98 9.68 13 129480 1098 63358431
Hearing disability 11.96 9.68 4 129489 33 63359496
Hepatic cirrhosis 11.95 9.68 20 129473 24714 63334815
Peritoneal adhesions 11.93 9.68 7 129486 240 63359289
Pyuria 11.92 9.68 17 129476 1897 63357632
Calculus bladder 11.85 9.68 10 129483 617 63358912
Neurotoxicity 11.83 9.68 67 129426 16923 63342606
Thyroxine increased 11.82 9.68 10 129483 619 63358910
Exfoliative rash 11.80 9.68 21 129472 2826 63356703
Conjunctival hyperaemia 11.79 9.68 19 129474 2360 63357169
Urethral pain 11.74 9.68 8 129485 357 63359172
Renal impairment 11.74 9.68 249 129244 88106 63271423
Dehydration 11.65 9.68 448 129045 172906 63186623
Endocarditis bacterial 11.64 9.68 10 129483 632 63358897
Drug dependence 11.64 9.68 20 129473 24463 63335066
Pleural neoplasm 11.62 9.68 8 129485 363 63359166
Myosclerosis 11.59 9.68 6 129487 160 63359369
Blood glucose increased 11.56 9.68 112 129381 83644 63275885
Eye swelling 11.55 9.68 86 129407 23832 63335697
Wrong technique in product usage process 11.54 9.68 77 129416 62263 63297266
Food allergy 11.53 9.68 50 129443 11351 63348178
Neoplasm progression 11.51 9.68 37 129456 36391 63323138
Inappropriate antidiuretic hormone secretion 11.45 9.68 62 129431 15400 63344129
Allodynia 11.40 9.68 11 129482 808 63358721
Dysaesthesia 11.40 9.68 27 129466 4451 63355078
Human ehrlichiosis 11.39 9.68 6 129487 166 63359363
Erythema multiforme 11.38 9.68 46 129447 10123 63349406
Hypertensive heart disease 11.36 9.68 19 129474 2433 63357096
Episcleritis 11.31 9.68 12 129481 988 63358541
Idiosyncratic drug reaction 11.30 9.68 11 129482 817 63358712
Injection site rash 11.30 9.68 13 129480 18796 63340733
Coeliac disease 11.28 9.68 6 129487 12791 63346738
Peripheral venous disease 11.28 9.68 9 129484 15468 63344061
Skin plaque 11.27 9.68 40 129453 8280 63351249
Fracture 11.27 9.68 14 129479 19570 63339959
Anal skin tags 11.26 9.68 9 129484 514 63359015
Myositis 11.25 9.68 43 129450 9223 63350306
Mucous stools 11.24 9.68 26 129467 4222 63355307
Mineral metabolism disorder 11.21 9.68 3 129490 10 63359519
Levator syndrome 11.21 9.68 3 129490 10 63359519
Quadriparesis 11.16 9.68 17 129476 2012 63357517
Sense of oppression 11.15 9.68 12 129481 1004 63358525
Respiratory gas exchange disorder 11.12 9.68 8 129485 390 63359139
Injection site thrombosis 11.06 9.68 5 129488 98 63359431
Toxic encephalopathy 11.03 9.68 34 129459 6545 63352984
Choriocarcinoma 11.02 9.68 4 129489 43 63359486
Lupus-like syndrome 11.01 9.68 9 129484 15286 63344243
Aural polyp 10.97 9.68 5 129488 100 63359429
Acute psychosis 10.95 9.68 19 129474 2506 63357023
Gallbladder injury 10.93 9.68 14 129479 1409 63358120
Underdose 10.84 9.68 25 129468 27431 63332098
Transient ischaemic attack 10.81 9.68 40 129453 37713 63321816
Plasmapheresis 10.80 9.68 7 129486 287 63359242
Noninfective gingivitis 10.79 9.68 14 129479 1427 63358102
Increased tendency to bruise 10.79 9.68 4 129489 10548 63348981
Cranial nerve disorder 10.79 9.68 9 129484 546 63358983
Skin burning sensation 10.78 9.68 53 129440 12681 63346848
Corynebacterium infection 10.74 9.68 9 129484 550 63358979
Hyperinsulinaemia 10.66 9.68 5 129488 107 63359422
Tachypnoea 10.61 9.68 66 129427 17236 63342293
Dysphagia 10.61 9.68 246 129247 88339 63271190
Leuconostoc infection 10.60 9.68 3 129490 13 63359516
Hypoperfusion 10.60 9.68 14 129479 1453 63358076
Biopsy colon abnormal 10.57 9.68 5 129488 109 63359420
Hypoaesthesia 10.57 9.68 432 129061 167961 63191568
Forced vital capacity decreased 10.55 9.68 12 129481 1067 63358462
Injection site urticaria 10.49 9.68 8 129485 14065 63345464
Graft versus host disease 10.47 9.68 34 129459 6729 63352800
Lower limb fracture 10.44 9.68 21 129472 24200 63335329
Clostridium bacteraemia 10.37 9.68 6 129487 200 63359329
Meniscus injury 10.33 9.68 35 129458 7079 63352450
Bacterial endophthalmitis 10.33 9.68 5 129488 115 63359414
Post viral fatigue syndrome 10.32 9.68 7 129486 310 63359219
Foreign body aspiration 10.32 9.68 6 129487 202 63359327
Jaundice 10.30 9.68 98 129395 29153 63330376
Pneumonia mycoplasmal 10.28 9.68 11 129482 914 63358615
Hepatocellular injury 10.28 9.68 93 129400 27288 63332241
Bovine tuberculosis 10.27 9.68 4 129489 53 63359476
Right ventricular failure 10.19 9.68 12 129481 17176 63342353
Therapeutic response unexpected 10.19 9.68 14 129479 18745 63340784
Vulvovaginal candidiasis 10.18 9.68 21 129472 3154 63356375
Mesenteritis 10.18 9.68 7 129486 317 63359212
Staphylococcal sepsis 10.10 9.68 38 129455 8090 63351439
Papule 10.10 9.68 30 129463 5661 63353868
Injection site mass 10.06 9.68 14 129479 18642 63340887
Urinary tract infection bacterial 10.05 9.68 28 129465 5094 63354435
Small fibre neuropathy 10.04 9.68 8 129485 455 63359074
Granulomatous liver disease 10.00 9.68 10 129483 768 63358761
Folate deficiency 9.93 9.68 18 129475 2457 63357072
Paraneoplastic syndrome 9.89 9.68 9 129484 614 63358915
Stroke in evolution 9.88 9.68 4 129489 59 63359470
C-reactive protein decreased 9.88 9.68 11 129482 956 63358573
Gastrointestinal sounds abnormal 9.86 9.68 24 129469 4027 63355502
Lower respiratory tract infection bacterial 9.84 9.68 8 129485 468 63359061
Skin warm 9.84 9.68 29 129464 5447 63354082
Purpura fulminans 9.82 9.68 4 129489 60 63359469
Urine odour abnormal 9.78 9.68 32 129461 6357 63353172
Mitochondrial toxicity 9.77 9.68 8 129485 473 63359056
Drug withdrawal syndrome 9.77 9.68 26 129467 27168 63332361
Porphyria acute 9.71 9.68 12 129481 1165 63358364
Epilepsy 9.69 9.68 91 129402 26974 63332555
Thrombocytosis 9.69 9.68 30 129463 5788 63353741

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Tendon pain 711.36 10.52 278 94988 2717 34858948
Tendonitis 568.87 10.52 338 94928 8802 34852863
Tendon rupture 456.53 10.52 267 94999 6745 34854920
Tendon disorder 254.38 10.52 134 95132 2741 34858924
Pathogen resistance 235.27 10.52 200 95066 9282 34852383
Death 226.21 10.52 467 94799 397582 34464083
Toxic epidermal necrolysis 210.66 10.52 277 94989 21369 34840296
Tendon discomfort 188.18 10.52 56 95210 210 34861455
Drug hypersensitivity 167.12 10.52 541 94725 79988 34781677
Drug abuse 155.87 10.52 39 95227 99057 34762608
Completed suicide 153.71 10.52 39 95227 98129 34763536
Drug reaction with eosinophilia and systemic symptoms 150.30 10.52 299 94967 32713 34828952
Drug interaction 128.75 10.52 1053 94213 224893 34636772
Myocardial infarction 123.36 10.52 90 95176 120995 34740670
Joint noise 110.21 10.52 48 95218 630 34861035
Clostridium difficile colitis 108.54 10.52 171 95095 15559 34846106
Choroiditis 108.53 10.52 57 95209 1158 34860507
Myalgia 104.32 10.52 480 94786 83630 34778035
Night sweats 102.68 10.52 176 95090 17176 34844489
Tubulointerstitial nephritis 98.79 10.52 193 95073 20831 34840834
Drug resistance 98.38 10.52 218 95048 25709 34835956
Eye pain 84.23 10.52 140 95126 13322 34848343
Tinnitus 81.85 10.52 174 95092 19944 34841721
Product dose omission issue 80.58 10.52 126 95140 119585 34742080
Toxicity to various agents 74.15 10.52 288 94978 200074 34661591
Paraesthesia 72.82 10.52 357 94909 63815 34797850
Intentional overdose 70.97 10.52 16 95250 43658 34818007
Solar lentigo 70.59 10.52 33 95233 516 34861149
Hyperacusis 69.39 10.52 38 95228 842 34860823
Dysplastic naevus 67.47 10.52 31 95235 465 34861200
Anal fissure 66.99 10.52 70 95196 4220 34857445
Cerebrovascular accident 66.37 10.52 80 95186 84731 34776934
Septic shock 66.00 10.52 377 94889 71457 34790208
Panic attack 65.71 10.52 103 95163 9329 34852336
Arthralgia 65.53 10.52 730 94536 169311 34692354
Photodermatosis 63.72 10.52 31 95235 532 34861133
Fistula 62.64 10.52 85 95181 6755 34854910
Torsade de pointes 62.13 10.52 87 95179 7122 34854543
Fall 62.12 10.52 313 94953 202572 34659093
Intraocular pressure increased 60.44 10.52 74 95192 5309 34856356
Overdose 60.16 10.52 97 95169 90962 34770703
Muscle rupture 60.14 10.52 50 95216 2248 34859417
Stevens-Johnson syndrome 56.89 10.52 144 95122 18495 34843170
Henoch-Schonlein purpura 56.08 10.52 42 95224 1620 34860045
Hyperfibrinolysis 55.34 10.52 13 95253 12 34861653
Rash morbilliform 54.82 10.52 54 95212 3033 34858632
Spinal muscular atrophy 54.65 10.52 25 95241 371 34861294
Dysbiosis 53.80 10.52 27 95239 497 34861168
Muscle twitching 52.64 10.52 98 95168 10200 34851465
Trichoglossia 52.59 10.52 23 95243 305 34861360
Pseudomembranous colitis 51.77 10.52 50 95216 2741 34858924
Pyrexia 51.44 10.52 1228 94038 331785 34529880
Wrong technique in product usage process 51.31 10.52 17 95249 35969 34825696
Cardiac failure congestive 51.07 10.52 93 95173 83177 34778488
Rash maculo-papular 50.04 10.52 181 95085 28270 34833395
Abdominal abscess 49.50 10.52 59 95207 4116 34857549
Tracheobronchomegaly 49.21 10.52 12 95254 15 34861650
Neuralgia 48.48 10.52 119 95147 14994 34846671
Ligament pain 48.33 10.52 13 95253 30 34861635
Clostridium difficile infection 46.63 10.52 135 95131 18763 34842902
Ependymoma 45.91 10.52 11 95255 12 34861653
Motor neurone disease 45.46 10.52 24 95242 493 34861172
Cutaneous vasculitis 45.29 10.52 57 95209 4206 34857459
Colitis 44.23 10.52 212 95054 37538 34824127
Candida infection 43.18 10.52 126 95140 17589 34844076
Sputum increased 43.10 10.52 42 95224 2328 34859337
Foetal cardiac arrest 42.65 10.52 11 95255 20 34861645
Foetal exposure during pregnancy 41.86 10.52 26 95240 38075 34823590
Vanishing bile duct syndrome 41.84 10.52 29 95237 989 34860676
Pseudomonas infection 41.32 10.52 99 95167 12283 34849382
Suicide attempt 39.88 10.52 29 95237 39087 34822578
Muscle atrophy 39.78 10.52 72 95194 7332 34854333
Skin injury 39.76 10.52 40 95226 2305 34859360
Injection site pain 39.66 10.52 29 95237 38976 34822689
Condition aggravated 39.41 10.52 739 94527 191457 34670208
Photosensitivity reaction 38.97 10.52 88 95178 10506 34851159
Factor V inhibition 38.85 10.52 16 95250 181 34861484
Pneumococcal sepsis 36.74 10.52 28 95238 1109 34860556
Stoma closure 36.58 10.52 17 95249 262 34861403
COVID-19 36.58 10.52 100 95166 77450 34784215
Fixed eruption 36.43 10.52 33 95233 1667 34859998
Cardiac failure 36.41 10.52 127 95139 91121 34770544
Inflammation 36.16 10.52 163 95103 28132 34833533
Cross sensitivity reaction 35.74 10.52 30 95236 1367 34860298
Linear IgA disease 35.70 10.52 32 95234 1594 34860071
Acute myocardial infarction 35.67 10.52 57 95209 53662 34808003
Impaired work ability 35.48 10.52 66 95200 6864 34854801
Acute generalised exanthematous pustulosis 35.28 10.52 65 95201 6711 34854954
Eosinophilia 34.97 10.52 153 95113 26069 34835596
Malignant neoplasm progression 34.83 10.52 123 95143 87923 34773742
Visual acuity reduced 34.80 10.52 110 95156 16039 34845626
Tendon injury 34.76 10.52 25 95241 905 34860760
Hyphaema 34.67 10.52 21 95245 566 34861099
Blood glucose increased 34.58 10.52 82 95184 66636 34795029
Ischaemic cerebral infarction 34.45 10.52 28 95238 1219 34860446
Acute kidney injury 34.07 10.52 1079 94187 303909 34557756
Aortic valve prolapse 33.26 10.52 8 95258 9 34861656
Musculoskeletal injury 33.16 10.52 13 95253 128 34861537
Anal abscess 32.33 10.52 61 95205 6412 34855253
Pelvic abscess 32.28 10.52 24 95242 915 34860750
Pancreatic enzyme abnormality 32.22 10.52 11 95255 70 34861595
Dyspnoea 32.15 10.52 782 94484 376000 34485665
Escherichia infection 32.03 10.52 70 95196 8175 34853490
Yellow fever 31.87 10.52 7 95259 3 34861662
Metabolic disorder 31.55 10.52 48 95218 4235 34857430
Burning sensation 31.48 10.52 116 95150 18278 34843387
Anal fistula 30.93 10.52 54 95212 5345 34856320
Coronary artery disease 30.46 10.52 53 95213 48252 34813413
Hepatitis cholestatic 30.33 10.52 67 95199 7880 34853785
Prostatitis 30.16 10.52 54 95212 5453 34856212
Increased bronchial secretion 29.92 10.52 31 95235 1850 34859815
Clostridium test positive 29.80 10.52 41 95225 3301 34858364
Lower respiratory tract infection bacterial 29.79 10.52 18 95248 483 34861182
Diastasis recti abdominis 29.59 10.52 9 95257 37 34861628
Undersensing 29.52 10.52 7 95259 7 34861658
Uveitis 29.30 10.52 64 95202 7471 34854194
Lymphadenectomy 28.57 10.52 16 95250 371 34861294
Pain in extremity 28.56 10.52 494 94772 126019 34735646
Sphingomonas paucimobilis infection 28.50 10.52 9 95257 43 34861622
Anuria 28.38 10.52 77 95189 10308 34851357
Urosepsis 28.33 10.52 88 95178 12711 34848954
Pyelonephritis fungal 28.24 10.52 10 95256 72 34861593
Penis injury 28.03 10.52 14 95252 255 34861410
Aspergillus infection 27.82 10.52 85 95181 12169 34849496
Abscess 27.80 10.52 83 95183 11734 34849931
Bradycardia 27.45 10.52 109 95157 75309 34786356
Connective tissue disorder 27.15 10.52 13 95253 215 34861450
Hypoaesthesia 26.98 10.52 271 94995 61173 34800492
Psoriasis 26.90 10.52 40 95226 38772 34822893
Chest pain 26.72 10.52 219 95047 126543 34735122
Infective pulmonary exacerbation of cystic fibrosis 26.71 10.52 58 95208 6743 34854922
Infective aneurysm 26.68 10.52 18 95248 587 34861078
Disease complication 26.58 10.52 35 95231 2701 34858964
Chronic fatigue syndrome 26.47 10.52 15 95251 356 34861309
Angina pectoris 26.24 10.52 28 95238 31335 34830330
Intentional product misuse 26.15 10.52 53 95213 45558 34816107
Renal tubular necrosis 26.09 10.52 98 95168 15582 34846083
Rectal abscess 26.00 10.52 25 95241 1363 34860302
Crohn's disease 25.94 10.52 37 95229 3080 34858585
Leukocytosis 25.94 10.52 132 95134 23933 34837732
Abdominal pain 25.64 10.52 605 94661 163013 34698652
Penile haemorrhage 25.58 10.52 18 95248 629 34861036
Coma 25.41 10.52 54 95212 45624 34816041
Stenotrophomonas infection 25.31 10.52 30 95236 2080 34859585
Chronic gastrointestinal bleeding 25.18 10.52 14 95252 320 34861345
Asthma 24.94 10.52 49 95217 42607 34819058
Hospitalisation 24.91 10.52 76 95190 56826 34804839
Diabetic ketoacidosis 24.87 10.52 9 95257 18023 34843642
Bone cyst 24.79 10.52 26 95240 1574 34860091
Vitreous floaters 24.76 10.52 39 95227 3546 34858119
Yellow fever vaccine-associated viscerotropic disease 24.54 10.52 5 95261 0 34861665
Sensory processing disorder 24.54 10.52 5 95261 0 34861665
Enterococcal infection 24.44 10.52 68 95198 9238 34852427
Radiation inflammation 24.33 10.52 20 95246 885 34860780
Hypertension 24.29 10.52 246 95020 136197 34725468
Anxiety 24.17 10.52 393 94873 99035 34762630
Walking aid user 24.15 10.52 28 95238 1896 34859769
Chronic obstructive pulmonary disease 23.88 10.52 62 95204 48856 34812809
Somnolence 23.86 10.52 191 95075 110925 34750740
Phlebitis infective 23.76 10.52 10 95256 120 34861545
Hypnagogic hallucination 23.55 10.52 8 95258 50 34861615
Rash erythematous 23.51 10.52 132 95134 24845 34836820
Joint ankylosis 23.39 10.52 25 95241 1547 34860118
Gluten sensitivity 22.97 10.52 7 95259 29 34861636
Sopor 22.88 10.52 3 95263 12133 34849532
Pruritus genital 22.67 10.52 29 95237 2175 34859490
Pouchitis 22.29 10.52 17 95249 674 34860991
Cystic fibrosis 22.29 10.52 25 95241 1633 34860032
Geotrichum infection 22.24 10.52 15 95251 489 34861176
Bronchial disorder 22.10 10.52 23 95243 1380 34860285
Lumbosacral plexus injury 21.97 10.52 6 95260 15 34861650
Auditory disorder 21.71 10.52 12 95254 271 34861394
Nosocomial infection 21.46 10.52 21 95245 1170 34860495
Corneal deposits 21.42 10.52 11 95255 213 34861452
Chest injury 21.41 10.52 24 95242 1567 34860098
Necrotising retinitis 21.37 10.52 18 95248 824 34860841
Drug-induced liver injury 21.23 10.52 143 95123 28689 34832976
Acinetobacter infection 21.22 10.52 21 95245 1186 34860479
Urinary tract infection 21.05 10.52 334 94932 83747 34777918
Painful respiration 20.80 10.52 21 95245 1215 34860450
Premature baby 20.74 10.52 14 95252 19619 34842046
Ischaemic stroke 20.68 10.52 12 95254 18238 34843427
Cardio-respiratory arrest 20.67 10.52 79 95187 55194 34806471
Disease progression 20.43 10.52 192 95074 107885 34753780
Obesity 20.36 10.52 5 95261 12873 34848792
Palpitations 20.35 10.52 182 95084 39804 34821861
Visual impairment 20.35 10.52 167 95099 35635 34826030
Pulmonary embolism 20.32 10.52 152 95114 89594 34772071
Prostate cancer 20.32 10.52 49 95217 39600 34822065
Deep vein thrombosis 20.29 10.52 100 95166 65148 34796517
Metastases to liver 20.29 10.52 6 95260 13657 34848008
Nasopharyngitis 20.20 10.52 110 95156 69858 34791807
Anti-cyclic citrullinated peptide antibody positive 20.15 10.52 25 95241 1818 34859847
Enterocutaneous fistula 20.06 10.52 19 95247 1016 34860649
Platelet count decreased 20.02 10.52 219 95047 119498 34742167
Food intolerance 19.93 10.52 22 95244 1412 34860253
Hepatic encephalopathy 19.82 10.52 86 95180 14599 34847066
Right ventricle outflow tract obstruction 19.78 10.52 5 95261 8 34861657
Infusion related reaction 19.74 10.52 76 95190 52981 34808684
Posterior tibial tendon dysfunction 19.63 10.52 4 95262 0 34861665
Yellow fever vaccine-associated neurotropic disease 19.63 10.52 4 95262 0 34861665
Product quality issue 19.59 10.52 11 95255 17024 34844641
Vitamin K deficiency 19.49 10.52 11 95255 259 34861406
Neuropathy peripheral 19.45 10.52 327 94939 82936 34778729
COVID-19 pneumonia 19.45 10.52 11 95255 16956 34844709
Cholestasis 19.45 10.52 133 95133 26815 34834850
Cardiac disorder 19.30 10.52 57 95209 43069 34818596
Organic brain syndrome 19.26 10.52 11 95255 265 34861400
Faciobrachial dystonic seizure 19.24 10.52 7 95259 55 34861610
Pulmonary pain 19.16 10.52 20 95246 1204 34860461
Lip erosion 19.11 10.52 15 95251 621 34861044
Abscess intestinal 19.08 10.52 23 95243 1623 34860042
Orchitis 19.05 10.52 23 95243 1626 34860039
Defaecation urgency 19.05 10.52 29 95237 2560 34859105
Aeromonas infection 18.97 10.52 11 95255 273 34861392
Megacolon 18.91 10.52 24 95242 1786 34859879
Leukocyturia 18.84 10.52 15 95251 634 34861031
Oxidative stress 18.81 10.52 7 95259 59 34861606
Intentional self-injury 18.78 10.52 7 95259 13764 34847901
Neuroleptic malignant syndrome 18.67 10.52 13 95253 17921 34843744
Agranulocytosis 18.66 10.52 120 95146 23701 34837964
Increased viscosity of bronchial secretion 18.66 10.52 10 95256 212 34861453
Incorrect dose administered 18.53 10.52 53 95213 40462 34821203
Treatment noncompliance 18.48 10.52 30 95236 28070 34833595
Systemic candida 18.47 10.52 35 95231 3691 34857974
Nail bed bleeding 18.35 10.52 12 95254 371 34861294
Cerebral infarction 18.35 10.52 29 95237 27426 34834239
Accidental exposure to product 18.33 10.52 6 95260 12796 34848869
Product administration error 18.16 10.52 11 95255 16333 34845332
Aortic aneurysm rupture 18.11 10.52 18 95248 1022 34860643
Clostridial infection 17.89 10.52 34 95232 3593 34858072
Nail bed inflammation 17.77 10.52 9 95257 169 34861496
Muscle injury 17.65 10.52 21 95245 1462 34860203
Respiratory tract infection bacterial 17.63 10.52 23 95243 1759 34859906
Multiple organ dysfunction syndrome 17.63 10.52 300 94966 76266 34785399
Anxiety disorder 17.51 10.52 23 95243 1771 34859894
Plantar fasciitis 17.44 10.52 25 95241 2091 34859574
Gastrointestinal inflammation 17.43 10.52 33 95233 3478 34858187
Musculoskeletal discomfort 17.42 10.52 55 95211 8013 34853652
Dyspnoea exertional 17.41 10.52 60 95206 43219 34818446
Prolapse 17.40 10.52 4 95262 3 34861662
Necrotising scleritis 17.33 10.52 7 95259 75 34861590
Weight bearing difficulty 17.33 10.52 18 95248 1077 34860588
Muscle tightness 17.33 10.52 40 95226 4844 34856821
Trichosporon infection 17.22 10.52 15 95251 719 34860946
Magnesium deficiency 17.17 10.52 7 95259 77 34861588
Cystitis 17.06 10.52 62 95204 9703 34851962
Haematospermia 17.05 10.52 11 95255 332 34861333
Generalised oedema 17.00 10.52 73 95193 12335 34849330
Hyperthyroidism 16.90 10.52 4 95262 10562 34851103
Septic embolus 16.88 10.52 19 95247 1246 34860419
Kounis syndrome 16.85 10.52 27 95239 2491 34859174
Intestinal stenosis 16.82 10.52 25 95241 2161 34859504
Intestinal fistula 16.78 10.52 17 95249 988 34860677
Scleromalacia 16.75 10.52 5 95261 19 34861646
Cholestatic liver injury 16.72 10.52 26 95240 2338 34859327
Mucosal disorder 16.64 10.52 22 95244 1704 34859961
Dermatitis bullous 16.64 10.52 49 95217 6873 34854792
Nephritis allergic 16.53 10.52 12 95254 441 34861224
Joint stiffness 16.49 10.52 66 95200 10807 34850858
Hyperkalaemia 16.44 10.52 116 95150 69273 34792392
Resuscitation 16.35 10.52 20 95246 1433 34860232
Throat tightness 16.27 10.52 55 95211 8303 34853362
Hypogonadism 16.23 10.52 25 95241 2230 34859435
Muscle fatigue 16.22 10.52 20 95246 1445 34860220
Lung consolidation 16.21 10.52 44 95222 5892 34855773
Retinitis viral 16.13 10.52 7 95259 91 34861574
Fat tissue decreased 16.13 10.52 7 95259 91 34861574
Cough 16.13 10.52 300 94966 149840 34711825
Necrotising fasciitis 16.08 10.52 33 95233 3689 34857976
Epistaxis 16.04 10.52 93 95173 58158 34803507
Escherichia urinary tract infection 15.98 10.52 32 95234 3514 34858151
Procalcitonin decreased 15.86 10.52 7 95259 95 34861570
Corneal opacity 15.86 10.52 13 95253 573 34861092
Drug dependence 15.79 10.52 26 95240 24191 34837474
Pharyngeal erythema 15.71 10.52 14 95252 692 34860973
Urinary tract obstruction 15.52 10.52 32 95234 3588 34858077
Catatonia 15.51 10.52 39 95227 4986 34856679
Fluorosis 15.50 10.52 6 95260 57 34861608
Hepatotoxicity 15.48 10.52 106 95160 21379 34840286
Therapeutic product effect incomplete 15.40 10.52 78 95188 50463 34811202
Perirectal abscess 15.39 10.52 21 95245 1677 34859988
Angina bullosa haemorrhagica 15.31 10.52 6 95260 59 34861606
Intestinal intraepithelial lymphocytes increased 15.25 10.52 8 95258 162 34861503
Myocardial ischaemia 15.18 10.52 15 95251 17393 34844272
Flushing 15.13 10.52 42 95224 32378 34829287
Exposure during pregnancy 15.07 10.52 3 95263 8931 34852734
Injection site haemorrhage 15.04 10.52 4 95262 9764 34851901
Ligament injury 14.99 10.52 10 95256 320 34861345
Influenza 14.94 10.52 77 95189 49589 34812076
Oesophageal mucosa erythema 14.89 10.52 5 95261 30 34861635
Cardiac arrest 14.86 10.52 179 95087 95980 34765685
Scoliosis 14.80 10.52 27 95239 2766 34858899
Actinic keratosis 14.69 10.52 36 95230 4531 34857134
Abscess bacterial 14.58 10.52 8 95258 178 34861487
Sensitisation 14.50 10.52 8 95258 180 34861485
Nutritional condition abnormal 14.47 10.52 11 95255 434 34861231
Gingival recession 14.47 10.52 11 95255 434 34861231
Blood cholesterol increased 14.40 10.52 21 95245 20522 34841143
Febrile neutropenia 14.39 10.52 481 94785 136368 34725297
Withdrawal syndrome 14.38 10.52 8 95258 12447 34849218
Blood creatine phosphokinase increased 14.38 10.52 68 95198 44789 34816876
Salivary hypersecretion 14.38 10.52 3 95263 8641 34853024
Skin burning sensation 14.30 10.52 36 95230 4607 34857058
Necrosis 14.23 10.52 41 95225 5682 34855983
Crystal nephropathy 14.21 10.52 11 95255 446 34861219
Gynaecomastia 14.18 10.52 5 95261 10175 34851490
Lymphocyte count decreased 14.09 10.52 25 95241 22597 34839068
Glomerular filtration rate decreased 14.02 10.52 9 95257 12952 34848713
Ejection fraction decreased 14.00 10.52 19 95247 19135 34842530
Mucosal atrophy 13.97 10.52 6 95260 76 34861589
Klebsiella infection 13.93 10.52 53 95213 8478 34853187
Poisoning 13.91 10.52 8 95258 12218 34849447
Roseolovirus test positive 13.90 10.52 6 95260 77 34861588
Sitting disability 13.89 10.52 8 95258 196 34861469
Thrombocytosis 13.85 10.52 33 95233 4079 34857586
Haemorrhoids thrombosed 13.82 10.52 8 95258 198 34861467
Otorrhoea 13.80 10.52 12 95254 574 34861091
Hypotension 13.79 10.52 480 94786 221169 34640496
Blood triglycerides increased 13.79 10.52 11 95255 14148 34847517
Genital pain 13.77 10.52 11 95255 467 34861198
Probiotic therapy 13.75 10.52 7 95259 133 34861532
Eye infection fungal 13.71 10.52 10 95256 370 34861295
Osteolysis 13.70 10.52 28 95238 3120 34858545
Gastrooesophageal reflux disease 13.67 10.52 55 95211 37869 34823796
Thrombosis 13.66 10.52 81 95185 50377 34811288
Interstitial lung disease 13.64 10.52 113 95153 65169 34796496
Blood pressure increased 13.62 10.52 164 95102 87938 34773727
Skin wrinkling 13.60 10.52 10 95256 375 34861290
Ligament disorder 13.56 10.52 7 95259 137 34861528
Glycosylated haemoglobin increased 13.56 10.52 7 95259 11353 34850312
Aortic aneurysm 13.54 10.52 45 95221 6734 34854931
Thrombotic thrombocytopenic purpura 13.53 10.52 29 95237 3341 34858324
Incision site discharge 13.44 10.52 4 95262 15 34861650
Chest X-ray abnormal 13.44 10.52 34 95232 4364 34857301
Toxic encephalopathy 13.43 10.52 38 95228 5211 34856454
International normalised ratio increased 13.39 10.52 192 95074 47135 34814530
Haemoglobin decreased 13.38 10.52 240 95026 120532 34741133
Arteriosclerosis 13.38 10.52 8 95258 11960 34849705
Mental fatigue 13.34 10.52 7 95259 142 34861523
Epididymitis 13.32 10.52 24 95242 2435 34859230
Gallbladder polyp 13.30 10.52 10 95256 388 34861277
Subacute cutaneous lupus erythematosus 13.28 10.52 15 95251 987 34860678
Subdural haematoma 13.24 10.52 22 95244 20399 34841266
Erysipelas 13.23 10.52 36 95230 4827 34856838
Pruritus 13.18 10.52 492 94774 141489 34720176
Fluid retention 13.18 10.52 34 95232 26853 34834812
Left ventricular hypertrophy 13.16 10.52 3 95263 8127 34853538
Underdose 13.05 10.52 11 95255 13769 34847896
Small fibre neuropathy 13.00 10.52 6 95260 91 34861574
Hypophosphataemia 12.85 10.52 7 95259 11019 34850646
Pseudopolyp 12.84 10.52 8 95258 227 34861438
Constipation 12.82 10.52 280 94986 136702 34724963
Cryptitis 12.81 10.52 8 95258 228 34861437
Lactic acidosis 12.81 10.52 50 95216 34722 34826943
Motor dysfunction 12.80 10.52 45 95221 6929 34854736
Glare 12.77 10.52 6 95260 95 34861570
Scrotal pain 12.76 10.52 14 95252 892 34860773
Cervicobrachial syndrome 12.75 10.52 9 95257 316 34861349
Faecal calprotectin increased 12.74 10.52 24 95242 2520 34859145
Arterial angioplasty 12.69 10.52 5 95261 50 34861615
Pulmonary arterial hypertension 12.68 10.52 4 95262 8735 34852930
Cogwheel rigidity 12.68 10.52 17 95249 1335 34860330
Toxic skin eruption 12.65 10.52 63 95203 11322 34850343
Vertebral artery hypoplasia 12.65 10.52 3 95263 3 34861662
Spinal meningeal cyst 12.65 10.52 3 95263 3 34861662
Arthritis gonococcal 12.65 10.52 3 95263 3 34861662
Hepatic cytolysis 12.59 10.52 75 95191 14421 34847244
Pseudomonal sepsis 12.53 10.52 29 95237 3518 34858147
Jaundice 12.29 10.52 137 95129 31745 34829920
Atrioventricular block complete 12.27 10.52 5 95261 9314 34852351
Pulmonary hypertension 12.26 10.52 24 95242 20900 34840765
Urinary retention 12.24 10.52 152 95114 36136 34825529
Peroneal nerve palsy 12.19 10.52 26 95240 2985 34858680
Large intestinal stenosis 12.17 10.52 18 95248 1549 34860116
Myoglobin urine present 12.13 10.52 7 95259 172 34861493
Prescribed overdose 12.07 10.52 7 95259 10640 34851025
General physical health deterioration 12.06 10.52 262 95004 128007 34733658
Cardiogenic shock 12.04 10.52 35 95231 26583 34835082
Aspartate aminotransferase 12.03 10.52 6 95260 109 34861556
Hyperglycaemia 11.99 10.52 61 95205 39419 34822246
Joint instability 11.91 10.52 10 95256 456 34861209
Vertigo positional 11.89 10.52 13 95253 825 34860840
Osteonecrosis of jaw 11.85 10.52 19 95247 17870 34843795
Pruritus allergic 11.80 10.52 8 95258 263 34861402
Muscle discomfort 11.78 10.52 6 95260 114 34861551
Cerebral ischaemia 11.78 10.52 41 95225 6281 34855384
White blood cell count decreased 11.76 10.52 186 95080 95259 34766406
Idiosyncratic drug reaction 11.72 10.52 10 95256 466 34861199
Fear of death 11.70 10.52 11 95255 583 34861082
Pneumonia pseudomonal 11.65 10.52 30 95236 3892 34857773
Mucosal hyperaemia 11.64 10.52 4 95262 26 34861639
Prothrombin time shortened 11.63 10.52 17 95249 1447 34860218
Incorrect route of product administration 11.60 10.52 14 95252 14831 34846834
Device malfunction 11.60 10.52 7 95259 10414 34851251
Hand deformity 11.59 10.52 29 95237 3696 34857969
Dysuria 11.55 10.52 119 95147 27033 34834632
Hepatic amoebiasis 11.52 10.52 5 95261 65 34861600
Anal stenosis 11.51 10.52 7 95259 190 34861475
Hypersensitivity vasculitis 11.49 10.52 27 95239 3308 34858357
Depressed level of consciousness 11.47 10.52 69 95197 42772 34818893
Pseudoporphyria 11.45 10.52 9 95257 373 34861292
Renal abscess 11.43 10.52 8 95258 277 34861388
Psoas abscess 11.42 10.52 11 95255 601 34861064
Microvillous inclusion disease 11.42 10.52 7 95259 193 34861472
Angina unstable 11.41 10.52 9 95257 11644 34850021
Graft versus host disease 11.41 10.52 58 95208 10511 34851154
Retinopathy hypertensive 11.38 10.52 8 95258 279 34861386
Aggression 11.38 10.52 61 95205 38903 34822762
Atelectasis 11.34 10.52 85 95181 17642 34844023
Hyperinsulinaemia 11.32 10.52 5 95261 68 34861597
Eye excision 11.27 10.52 4 95262 29 34861636
Breast inflammation 11.27 10.52 4 95262 29 34861636
Systemic inflammatory response syndrome 11.22 10.52 42 95224 6667 34854998
Muscle contractions involuntary 11.21 10.52 19 95247 1837 34859828
Hypofibrinogenaemia 11.17 10.52 18 95248 1668 34859997
Hyperoxaluria 11.16 10.52 6 95260 128 34861537
Stenotrophomonas test positive 11.14 10.52 8 95258 289 34861376
Pudendal canal syndrome 11.13 10.52 3 95263 7 34861658
Blood catecholamines decreased 11.13 10.52 3 95263 7 34861658
Microbiology test abnormal 11.13 10.52 3 95263 7 34861658
Neuropsychiatric symptoms 11.11 10.52 13 95253 889 34860776
Right ventricular failure 11.11 10.52 5 95261 8779 34852886
Loss of proprioception 11.09 10.52 9 95257 391 34861274
Bacterial disease carrier 11.06 10.52 10 95256 504 34861161
Presyncope 11.05 10.52 22 95244 19037 34842628
Ligament rupture 11.04 10.52 14 95252 1041 34860624
Lower gastrointestinal haemorrhage 11.02 10.52 6 95260 9446 34852219
Bladder spasm 11.00 10.52 13 95253 899 34860766
Wound drainage 10.97 10.52 11 95255 631 34861034
Unmasking of previously unidentified disease 10.97 10.52 13 95253 901 34860764
Cataract subcapsular 10.97 10.52 9 95257 397 34861268
Osteoporosis 10.95 10.52 11 95255 12657 34849008
Disseminated intravascular coagulation 10.94 10.52 99 95167 21717 34839948
Purpura non-thrombocytopenic 10.88 10.52 5 95261 75 34861590
Apoptosis 10.88 10.52 9 95257 402 34861263
Walking disability 10.87 10.52 13 95253 910 34860755
Rash 10.85 10.52 725 94541 222027 34639638
Injection site bruising 10.85 10.52 5 95261 8658 34853007
Hepatic infarction 10.83 10.52 7 95259 212 34861453
Drain placement 10.82 10.52 5 95261 76 34861589
Seizure 10.79 10.52 211 95055 104646 34757019
Irritability 10.78 10.52 33 95233 24657 34837008
Spontaneous haematoma 10.76 10.52 10 95256 522 34861143
Abdominal wall abscess 10.75 10.52 10 95256 523 34861142
Type 2 diabetes mellitus 10.65 10.52 17 95249 16015 34845650
Jaundice cholestatic 10.64 10.52 33 95233 4761 34856904
Glomerulonephritis acute 10.64 10.52 6 95260 141 34861524
Dermatitis exfoliative 10.64 10.52 41 95225 6598 34855067
Yawning 10.60 10.52 10 95256 532 34861133
Sensory disturbance 10.60 10.52 39 95227 6138 34855527
Hepato-lenticular degeneration 10.59 10.52 3 95263 9 34861656
Contusion 10.58 10.52 57 95209 36307 34825358
Herpes zoster meningoencephalitis 10.54 10.52 8 95258 315 34861350
Flavobacterium infection 10.54 10.52 5 95261 81 34861584
Staphylococcal infection 10.53 10.52 136 95130 32624 34829041

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Tendon pain 1159.11 9.48 458 194569 5200 79544161
Tendonitis 855.70 9.48 599 194428 23231 79526130
Drug hypersensitivity 771.49 9.48 2023 193004 296893 79252468
Tendon rupture 546.29 9.48 351 194676 11775 79537586
Drug reaction with eosinophilia and systemic symptoms 482.92 9.48 686 194341 63558 79485803
Pathogen resistance 467.60 9.48 340 194687 14002 79535359
Tendon disorder 439.45 9.48 253 194774 6933 79542428
Toxic epidermal necrolysis 395.57 9.48 516 194511 44065 79505296
Drug interaction 350.71 9.48 1966 193061 413217 79136144
Tubulointerstitial nephritis 288.31 9.48 409 194618 37826 79511535
Completed suicide 277.22 9.48 127 194900 245640 79303721
Clostridium difficile colitis 274.53 9.48 366 194661 31917 79517444
Tendon discomfort 229.84 9.48 73 194954 406 79548955
Clostridium difficile infection 215.55 9.48 380 194647 42305 79507056
Pemphigus 215.47 9.48 6 195021 99576 79449785
Death 210.17 9.48 698 194329 565816 78983545
Tinnitus 195.22 9.48 372 194655 43961 79505400
Myalgia 192.90 9.48 932 194095 184709 79364652
Drug resistance 186.85 9.48 355 194672 41858 79507503
Synovitis 185.93 9.48 68 194959 150666 79398695
Rheumatoid arthritis 175.44 9.48 151 194876 208319 79341042
Stevens-Johnson syndrome 172.89 9.48 329 194698 38837 79510524
Drug abuse 171.40 9.48 92 194935 162599 79386762
Acute kidney injury 168.64 9.48 1976 193051 517428 79031933
Hand deformity 164.52 9.48 28 194999 103891 79445470
Glossodynia 156.81 9.48 31 194996 103306 79446055
Duodenal ulcer perforation 143.19 9.48 4 195023 66207 79483154
Fall 141.05 9.48 663 194364 486966 79062395
Pericarditis 137.30 9.48 42 194985 104194 79445167
Rash maculo-papular 132.51 9.48 368 194659 55710 79493651
Rheumatoid factor positive 131.74 9.48 3 195024 59836 79489525
Fistula 130.98 9.48 160 194867 12780 79536581
Maternal exposure during pregnancy 130.07 9.48 87 194940 136451 79412910
Intentional overdose 128.64 9.48 49 194978 105911 79443450
Helicobacter infection 126.69 9.48 12 195015 69692 79479669
Dysbiosis 123.11 9.48 60 194967 1159 79548202
Joint noise 122.28 9.48 91 194936 3883 79545478
Anti-cyclic citrullinated peptide antibody positive 119.90 9.48 28 194999 83115 79466246
Panic attack 118.92 9.48 213 194814 24003 79525358
Infusion related reaction 117.83 9.48 241 194786 229996 79319365
Paraesthesia 114.41 9.48 781 194246 175542 79373819
Systemic lupus erythematosus 112.98 9.48 79 194948 121070 79428291
Anxiety 110.66 9.48 1009 194018 247503 79301858
Contraindicated product administered 105.75 9.48 138 194889 157400 79391961
Torsade de pointes 105.44 9.48 178 194849 19134 79530227
Hyperacusis 104.21 9.48 66 194961 2157 79547204
Pseudomembranous colitis 104.10 9.48 94 194933 5280 79544081
Tendon injury 103.02 9.48 64 194963 2021 79547340
Anal fistula 101.47 9.48 104 194923 6840 79542521
Choroiditis 99.07 9.48 54 194973 1327 79548034
Eosinophilia 97.83 9.48 288 194739 45057 79504304
Wound 96.66 9.48 85 194942 116094 79433267
Acute generalised exanthematous pustulosis 94.15 9.48 159 194868 17095 79532266
Toxicity to various agents 94.07 9.48 624 194403 420916 79128445
Anal fissure 90.83 9.48 103 194924 7600 79541761
Muscle atrophy 90.39 9.48 124 194903 11108 79538253
Arthropathy 90.08 9.48 186 194841 176925 79372436
Injection site pain 86.86 9.48 114 194913 129724 79419637
Drug intolerance 86.70 9.48 342 194685 263777 79285584
Pyrexia 85.89 9.48 2219 192808 676490 78872871
Septic shock 85.09 9.48 553 194474 122248 79427113
Nasopharyngitis 84.45 9.48 327 194700 253554 79295807
Geotrichum infection 83.50 9.48 43 194984 938 79548423
Connective tissue disorder 83.36 9.48 48 194979 1315 79548046
Total lung capacity increased 83.00 9.48 58 194969 2240 79547121
Discomfort 81.29 9.48 113 194914 125504 79423857
Colitis 78.18 9.48 371 194656 72936 79476425
Product dose omission issue 77.19 9.48 327 194700 247210 79302151
Burning sensation 77.16 9.48 316 194711 58316 79491045
Multiple organ dysfunction syndrome 76.41 9.48 530 194497 119716 79429645
Alopecia 76.29 9.48 299 194728 231056 79318305
Suicide attempt 76.10 9.48 55 194972 82877 79466484
Early retirement 75.92 9.48 16 195011 5 79549356
Photosensitivity reaction 74.82 9.48 162 194865 20965 79528396
Pseudomonas infection 73.71 9.48 160 194867 20743 79528618
Folliculitis 73.49 9.48 22 195005 55358 79494003
Anal abscess 71.87 9.48 101 194926 9254 79540107
Candida infection 70.64 9.48 230 194797 37984 79511377
Abdominal pain 69.83 9.48 1339 193688 388230 79161131
Clostridium test positive 68.91 9.48 82 194945 6372 79542989
Impaired work ability 68.66 9.48 150 194877 19531 79529830
Factor V inhibition 68.21 9.48 28 194999 353 79549008
Henoch-Schonlein purpura 68.02 9.48 55 194972 2655 79546706
Dermatitis exfoliative 66.13 9.48 105 194922 10724 79538637
Hepatitis cholestatic 65.67 9.48 120 194907 13732 79535629
Dysplastic naevus 65.28 9.48 31 194996 564 79548797
Muscle twitching 65.02 9.48 169 194858 24595 79524766
Coma 64.66 9.48 91 194936 100558 79448803
Osteoporosis 62.45 9.48 27 195000 54085 79495276
Eye pain 62.24 9.48 218 194809 37360 79512001
Loss of employment 61.77 9.48 51 194976 2536 79546825
Linear IgA disease 61.09 9.48 55 194972 3077 79546284
Therapeutic product effect incomplete 60.62 9.48 163 194864 141482 79407879
Food intolerance 60.57 9.48 60 194967 3788 79545573
Neuropathy peripheral 60.44 9.48 569 194458 140736 79408625
Fixed eruption 59.85 9.48 53 194974 2901 79546460
Asthma-chronic obstructive pulmonary disease overlap syndrome 59.77 9.48 55 194972 3166 79546195
Joint swelling 59.06 9.48 438 194589 288208 79261153
Peripheral swelling 58.63 9.48 402 194625 269215 79280146
Vanishing bile duct syndrome 57.60 9.48 42 194985 1736 79547625
Cerebrovascular accident 56.91 9.48 192 194835 155100 79394261
Psoriatic arthropathy 56.90 9.48 64 194963 77935 79471426
Photodermatosis 56.44 9.48 33 194994 931 79548430
Nephritis allergic 56.44 9.48 30 194997 700 79548661
Muscle injury 56.41 9.48 24 195003 48537 79500824
Therapeutic product effect decreased 55.79 9.48 209 194818 163654 79385707
Malignant neoplasm progression 55.59 9.48 160 194867 135830 79413531
Impaired healing 55.56 9.48 80 194947 87575 79461786
Trimethylaminuria 55.10 9.48 20 195007 176 79549185
Injection site erythema 55.07 9.48 66 194961 78131 79471230
Exposure during pregnancy 55.04 9.48 102 194925 101030 79448331
Cross sensitivity reaction 54.97 9.48 56 194971 3656 79545705
Rash morbilliform 54.24 9.48 71 194956 6079 79543282
Solar lentigo 54.02 9.48 34 194993 1099 79548262
Renal tubular necrosis 53.97 9.48 159 194868 24880 79524481
Weight increased 53.88 9.48 427 194600 276959 79272402
Skin candida 53.75 9.48 43 194984 2044 79547317
Spinal muscular atrophy 53.61 9.48 24 195003 379 79548982
Abscess 53.60 9.48 150 194877 22801 79526560
Type 2 diabetes mellitus 53.57 9.48 37 194990 57085 79492276
Infective pulmonary exacerbation of cystic fibrosis 53.10 9.48 105 194922 12746 79536615
Neuralgia 53.00 9.48 191 194836 33193 79516168
Hepatic enzyme increased 52.82 9.48 248 194779 182362 79366999
Aspergillus infection 52.62 9.48 133 194894 19028 79530333
Injection site reaction 52.03 9.48 35 194992 54750 79494611
Hyperfibrinolysis 52.02 9.48 13 195014 23 79549338
COVID-19 51.81 9.48 204 194823 157470 79391891
Pulmonary pain 51.37 9.48 59 194968 4414 79544947
Muscle rupture 51.19 9.48 54 194973 3673 79545688
Myocardial infarction 50.40 9.48 255 194772 183874 79365487
Segmental diverticular colitis 49.83 9.48 18 195009 156 79549205
Psoriasis 49.07 9.48 90 194937 89497 79459864
Cardio-respiratory arrest 48.62 9.48 122 194905 108388 79440973
Rectal abscess 48.55 9.48 41 194986 2104 79547257
Pedal pulse abnormal 47.92 9.48 18 195009 176 79549185
Tracheobronchomegaly 47.58 9.48 11 195016 11 79549350
Vulvovaginal burning sensation 47.47 9.48 36 194991 1581 79547780
Cholecystitis chronic 47.19 9.48 86 194941 9820 79539541
Leukocytosis 47.11 9.48 221 194806 43234 79506127
Motor neurone disease 47.04 9.48 25 195002 583 79548778
Megacolon 46.87 9.48 50 194977 3445 79545916
Prescribed overdose 46.84 9.48 17 195010 37866 79511495
Treatment failure 46.72 9.48 236 194791 170250 79379111
Weight bearing difficulty 46.63 9.48 48 194979 3173 79546188
Vitreous floaters 46.59 9.48 72 194955 7184 79542177
Cardiac failure congestive 46.30 9.48 185 194842 142217 79407144
Cystic fibrosis 45.95 9.48 52 194975 3828 79545533
Toxic skin eruption 45.63 9.48 139 194888 22154 79527207
Sphingomonas paucimobilis infection 45.59 9.48 15 195012 95 79549266
Overdose 45.51 9.48 264 194763 183942 79365419
Escherichia infection 45.31 9.48 121 194906 17896 79531465
Sinusitis 45.25 9.48 286 194741 195215 79354146
Enterococcal infection 44.37 9.48 110 194917 15550 79533811
Accidental exposure to product 44.27 9.48 11 195016 31311 79518050
Musculoskeletal injury 43.89 9.48 17 195010 182 79549179
Device expulsion 43.12 9.48 6 195021 25855 79523506
Disturbance in attention 42.96 9.48 241 194786 50560 79498801
Infective aneurysm 42.51 9.48 28 194999 980 79548381
Blood cholesterol increased 42.47 9.48 88 194939 83632 79465729
Plantar fasciitis 42.05 9.48 47 194980 3413 79545948
Stomatitis 42.03 9.48 200 194827 146557 79402804
Therapeutic response decreased 41.41 9.48 62 194965 66791 79482570
Injection site swelling 41.01 9.48 33 194994 47099 79502262
Hip arthroplasty 41.01 9.48 18 195009 35738 79513623
Wrong technique in product usage process 40.65 9.48 74 194953 73801 79475560
Oesophageal spasm 40.39 9.48 46 194981 3410 79545951
Abnormal palmar/plantar creases 40.13 9.48 8 195019 0 79549361
Adverse event 40.12 9.48 53 194974 60161 79489200
Increased bronchial secretion 40.10 9.48 45 194982 3282 79546079
Sensory processing disorder 39.98 9.48 9 195018 7 79549354
Product administration error 39.87 9.48 14 195013 31832 79517529
Trichoglossia 39.75 9.48 23 195004 636 79548725
Fat tissue decreased 39.63 9.48 14 195013 113 79549248
Ligament pain 39.63 9.48 17 195010 241 79549120
Incorrect route of product administration 39.41 9.48 18 195009 34911 79514450
Febrile neutropenia 39.30 9.48 788 194239 230211 79319150
Injection site bruising 39.20 9.48 26 195001 40976 79508385
Acute myocardial infarction 39.06 9.48 81 194946 76955 79472406
Intraocular pressure increased 38.99 9.48 76 194951 9129 79540232
Drug-induced liver injury 38.83 9.48 286 194741 65831 79483530
Swelling 38.27 9.48 342 194685 216369 79332992
Penis injury 38.20 9.48 14 195013 127 79549234
Pouchitis 38.17 9.48 26 195001 963 79548398
Skin injury 37.56 9.48 44 194983 3362 79545999
Diarrhoea 37.31 9.48 2564 192463 877925 78671436
Muscle contractions involuntary 37.21 9.48 46 194981 3719 79545642
Stoma closure 36.68 9.48 17 195010 292 79549069
Lower respiratory tract infection bacterial 36.58 9.48 25 195002 931 79548430
Nervous system disorder 36.32 9.48 146 194881 26710 79522651
Abdominal pain lower 36.20 9.48 164 194863 31618 79517743
Cholestatic liver injury 35.98 9.48 52 194975 4889 79544472
Bradycardia 35.81 9.48 190 194837 135367 79413994
Product substitution issue 35.48 9.48 4 195023 20252 79529109
Nasal polyps 35.40 9.48 64 194963 7263 79542098
Thrombocytopenia 35.37 9.48 874 194153 264385 79284976
Intentional product misuse 35.31 9.48 117 194910 95048 79454313
Chronic fatigue syndrome 35.22 9.48 28 194999 1319 79548042
Nasal oedema 35.06 9.48 31 194996 1693 79547668
Depersonalisation/derealisation disorder 34.95 9.48 32 194995 1830 79547531
Fistula discharge 34.83 9.48 28 194999 1340 79548021
Emotional distress 34.72 9.48 191 194836 39778 79509583
Diastasis recti abdominis 34.66 9.48 9 195018 20 79549341
Hypertension 34.62 9.48 585 194442 330407 79218954
Hallucination 34.54 9.48 341 194686 85404 79463957
Acinetobacter infection 34.23 9.48 38 194989 2739 79546622
Dermatitis bullous 34.15 9.48 94 194933 14151 79535210
Calcium ionised decreased 34.12 9.48 20 195007 567 79548794
Abdominal abscess 34.11 9.48 62 194965 7065 79542296
Urinary tract infection 33.82 9.48 895 194132 273617 79275744
Cutaneous vasculitis 33.58 9.48 67 194960 8185 79541176
Depressed level of consciousness 33.06 9.48 123 194904 96529 79452832
Staphylococcal infection 33.01 9.48 250 194777 58045 79491316
Aortic valve prolapse 32.83 9.48 8 195019 12 79549349
Yellow fever 32.62 9.48 7 195020 3 79549358
Oesophageal pain 32.58 9.48 46 194981 4233 79545128
Female genital tract fistula 32.52 9.48 55 194972 5920 79543441
Hepatic encephalopathy 32.38 9.48 131 194896 24035 79525326
Lung consolidation 32.13 9.48 69 194958 8878 79540483
Live birth 32.09 9.48 4 195023 18740 79530621
Ill-defined disorder 31.95 9.48 71 194956 65804 79483557
Prostatitis 31.74 9.48 45 194982 4157 79545204
Contusion 31.73 9.48 223 194804 148553 79400808
Procedural anxiety 31.63 9.48 21 195006 745 79548616
Pregnancy 31.62 9.48 13 195014 26838 79522523
Factor V deficiency 31.55 9.48 11 195016 85 79549276
Crystal nephropathy 31.28 9.48 27 195000 1428 79547933
Diverticulitis 31.27 9.48 206 194821 45730 79503631
Klebsiella infection 31.23 9.48 97 194930 15623 79533738
Palpitations 30.98 9.48 458 194569 126152 79423209
Multiple sclerosis relapse 30.96 9.48 41 194986 46492 79502869
Escherichia urinary tract infection 30.96 9.48 89 194938 13736 79535625
Lymphoedema 30.85 9.48 83 194944 12330 79537031
Mobility decreased 30.75 9.48 174 194853 122001 79427360
Muscle tightness 30.74 9.48 85 194942 12829 79536532
Paraesthesia oral 30.71 9.48 115 194912 20356 79529005
Undersensing 30.28 9.48 7 195020 7 79549354
Mineral deficiency 30.17 9.48 9 195018 39 79549322
Poisoning 30.14 9.48 12 195015 25260 79524101
Sputum increased 29.94 9.48 46 194981 4567 79544794
Pulmonary arterial hypertension 29.91 9.48 16 195011 28350 79521011
Sepsis 29.69 9.48 866 194161 268562 79280799
Haematospermia 29.42 9.48 14 195013 256 79549105
Abdominal discomfort 29.27 9.48 434 194593 250293 79299068
Fungaemia 28.70 9.48 45 194982 4546 79544815
Cystitis 28.66 9.48 224 194803 52508 79496853
Hyphaema 28.49 9.48 21 195006 883 79548478
Visual acuity reduced 28.45 9.48 145 194882 29324 79520037
Non-consummation 28.34 9.48 9 195018 50 79549311
Anorectal ulcer 28.34 9.48 9 195018 50 79549311
Visual impairment 28.19 9.48 347 194680 91784 79457577
Pneumococcal sepsis 28.19 9.48 27 195000 1635 79547726
Drug dependence 28.08 9.48 35 194992 40734 79508627
Neutropenia 28.04 9.48 911 194116 286799 79262562
Rash erythematous 27.95 9.48 239 194788 57530 79491831
Drug ineffective 27.94 9.48 2271 192756 1078642 78470719
Hepatic cytolysis 27.92 9.48 136 194891 27015 79522346
Flushing 27.85 9.48 116 194911 88152 79461209
Penile haemorrhage 27.85 9.48 17 195010 520 79548841
Pancreatic enzyme abnormality 27.82 9.48 11 195016 125 79549236
Acute hepatic failure 27.57 9.48 146 194881 29967 79519394
Pulmonary hypertension 27.50 9.48 47 194980 48033 79501328
Somnolence 27.44 9.48 415 194612 238566 79310795
Sarcoidosis 27.36 9.48 62 194965 8273 79541088
Oliguria 27.34 9.48 95 194932 16214 79533147
Blood glucose increased 27.21 9.48 167 194860 114808 79434553
Bladder pain 27.13 9.48 31 194996 2306 79547055
Phlebitis 27.13 9.48 64 194963 8766 79540595
Hypotony of eye 26.96 9.48 13 195014 245 79549116
Dysuria 26.90 9.48 215 194812 50736 79498625
Osteonecrosis of jaw 26.85 9.48 40 194987 43186 79506175
Intentional self-injury 26.61 9.48 24 195003 32395 79516966
Cholestasis 26.49 9.48 218 194809 51891 79497470
Skin burning sensation 26.46 9.48 82 194945 13190 79536171
Sopor 26.43 9.48 25 195002 32985 79516376
Corneal deposits 26.43 9.48 16 195011 482 79548879
Mucosal inflammation 26.39 9.48 292 194735 75288 79474073
Polyneuropathy 26.30 9.48 123 194904 24028 79525333
Off label use 26.26 9.48 1888 193139 905327 78644034
Foot deformity 26.25 9.48 13 195014 24061 79525300
Radiation inflammation 26.24 9.48 20 195007 885 79548476
Corneal opacity 26.23 9.48 21 195006 999 79548362
Pudendal canal syndrome 25.95 9.48 6 195021 6 79549355
Hypoaesthesia 25.73 9.48 597 194430 178755 79370606
Rhinitis allergic 25.58 9.48 77 194950 12192 79537169
Lymphocyte count decreased 25.45 9.48 48 194979 47241 79502120
Cardiac failure 25.34 9.48 249 194778 154593 79394768
Sedation complication 25.29 9.48 4 195023 15665 79533696
Moraxella test positive 25.22 9.48 7 195020 22 79549339
Hypotension 25.20 9.48 853 194174 439464 79109897
Lividity 25.19 9.48 15 195012 438 79548923
Right ventricular failure 25.15 9.48 13 195014 23484 79525877
Yellow fever vaccine-associated viscerotropic disease 25.08 9.48 5 195022 0 79549361
Right ventricle outflow tract obstruction 25.08 9.48 5 195022 0 79549361
Cholelithiasis 25.02 9.48 217 194810 52447 79496914
Night sweats 24.93 9.48 215 194812 51880 79497481
Feeding intolerance 24.92 9.48 19 195008 841 79548520
Femur fracture 24.76 9.48 35 194992 38617 79510744
Abscess intestinal 24.63 9.48 32 194995 2719 79546642
Nerve injury 24.56 9.48 64 194963 9328 79540033
Sciatica 24.51 9.48 27 195000 33195 79516166
Injection site pruritus 24.49 9.48 41 194986 42242 79507119
Symmetrical drug-related intertriginous and flexural exanthema 24.42 9.48 19 195008 867 79548494
Osteonecrosis 24.38 9.48 24 195003 31071 79518290
Trichosporon infection 24.34 9.48 20 195007 988 79548373
Device malfunction 24.28 9.48 11 195016 21437 79527924
Amyloid arthropathy 24.19 9.48 16 195011 564 79548797
Systemic inflammatory response syndrome 23.94 9.48 72 194955 11393 79537968
Mitochondrial cytopathy 23.91 9.48 14 195013 396 79548965
Thrombotic thrombocytopenic purpura 23.86 9.48 50 194977 6326 79543035
Meningitis candida 23.82 9.48 10 195017 134 79549227
Pyelonephritis 23.81 9.48 106 194921 20282 79529079
Flank pain 23.81 9.48 104 194923 19740 79529621
Transient ischaemic attack 23.79 9.48 59 194968 52636 79496725
Sensory disturbance 23.71 9.48 86 194941 14991 79534370
Transmission of an infectious agent via product 23.68 9.48 11 195016 190 79549171
Aortic aneurysm 23.58 9.48 59 194968 8387 79540974
Fracture 23.43 9.48 12 195015 21789 79527572
Hallucinations, mixed 23.41 9.48 52 194975 6847 79542514
Injection site warmth 23.40 9.48 4 195023 14803 79534558
Ectropion 23.35 9.48 14 195013 414 79548947
Coronary artery disease 23.26 9.48 82 194945 65392 79483969
Breast cancer 23.26 9.48 29 194998 33752 79515609
Bacterial colitis 23.18 9.48 9 195018 97 79549264
Collagen disorder 23.09 9.48 12 195015 267 79549094
Erythema 23.05 9.48 712 194315 222578 79326783
Injection site hyperaesthesia 23.04 9.48 8 195019 61 79549300
Gastrointestinal infection 23.02 9.48 71 194956 11390 79537971
Potentiating drug interaction 22.96 9.48 60 194967 8759 79540602
Prescribed underdose 22.88 9.48 23 195004 29491 79519870
Depression 22.84 9.48 693 194334 216097 79333264
Clostridial infection 22.78 9.48 46 194981 5668 79543693
Loss of personal independence in daily activities 22.74 9.48 152 194875 102428 79446933
Lumbosacral plexus injury 22.62 9.48 6 195021 15 79549346
Lip dry 22.61 9.48 5 195022 15413 79533948
Urosepsis 22.60 9.48 126 194901 26369 79522992
Ependymoma 22.60 9.48 8 195019 65 79549296
Single functional kidney 22.54 9.48 12 195015 281 79549080
Chest injury 22.48 9.48 31 194996 2790 79546571
Product quality issue 22.48 9.48 30 194997 33910 79515451
Nosocomial infection 22.39 9.48 31 194996 2801 79546560
Stenotrophomonas infection 22.24 9.48 36 194991 3737 79545624
Diaphragmatic rupture 22.22 9.48 11 195016 220 79549141
Catatonia 22.21 9.48 59 194968 8697 79540664
Asthma 22.20 9.48 217 194810 134878 79414483
Toxic encephalopathy 22.18 9.48 70 194957 11370 79537991
Agranulocytosis 22.15 9.48 187 194840 44843 79504518
Aortic aneurysm rupture 21.89 9.48 21 195006 1274 79548087
Injection site mass 21.85 9.48 11 195016 20173 79529188
Septic embolus 21.80 9.48 26 195001 2025 79547336
Angina pectoris 21.77 9.48 60 194967 51672 79497689
Hyperkalaemia 21.77 9.48 177 194850 114221 79435140
Electrocardiogram QT prolonged 21.73 9.48 326 194701 90060 79459301
Tendon necrosis 21.63 9.48 5 195022 5 79549356
Long QT syndrome 21.47 9.48 46 194981 5909 79543452
Confabulation 21.41 9.48 14 195013 484 79548877
Gastrointestinal inflammation 21.38 9.48 53 194974 7491 79541870
Hypomania 21.38 9.48 53 194974 7491 79541870
Orchitis 21.27 9.48 21 195006 1320 79548041
Underdose 21.26 9.48 30 194997 33121 79516240
Documented hypersensitivity to administered product 21.23 9.48 18 195009 929 79548432
Ischaemic stroke 21.23 9.48 30 194997 33101 79516260
Staphylococcal scalded skin syndrome 21.23 9.48 13 195014 400 79548961
Road traffic accident 21.22 9.48 47 194980 43617 79505744
Thrombocytosis 21.18 9.48 57 194970 8469 79540892
Vulvovaginal pruritus 21.08 9.48 29 194998 2604 79546757
Idiosyncratic drug reaction 21.06 9.48 21 195006 1336 79548025
Haematuria 20.94 9.48 259 194768 68577 79480784
Jaundice cholestatic 20.92 9.48 68 194959 11216 79538145
Walking disability 20.88 9.48 26 195001 2117 79547244
Tooth disorder 20.85 9.48 20 195007 26213 79523148
Auditory disorder 20.73 9.48 14 195013 511 79548850
COVID-19 pneumonia 20.68 9.48 24 195003 28825 79520536
Pulmonary eosinophilia 20.66 9.48 16 195011 725 79548636
Herpes zoster 20.59 9.48 138 194889 92945 79456416
Bone marrow granuloma 20.50 9.48 6 195021 24 79549337
Excessive eye blinking 20.49 9.48 23 195004 1678 79547683
Hyperinsulinaemia 20.34 9.48 10 195017 197 79549164
Myosclerosis 20.29 9.48 10 195017 198 79549163
Acute febrile neutrophilic dermatosis 20.23 9.48 35 194992 3837 79545524
Drug level increased 20.22 9.48 166 194861 39485 79509876
Sleep disorder due to a general medical condition 20.20 9.48 5 195022 14272 79535089
Scleromalacia 20.09 9.48 7 195020 54 79549307
Tendon laxity 20.06 9.48 4 195023 0 79549361
Yellow fever vaccine-associated neurotropic disease 20.06 9.48 4 195023 0 79549361
Renal vein compression 20.06 9.48 4 195023 0 79549361
Posterior tibial tendon dysfunction 20.06 9.48 4 195023 0 79549361
Osteoarthritis 20.04 9.48 128 194899 87181 79462180
Hypophosphataemia 19.89 9.48 12 195015 19901 79529460
Disease progression 19.86 9.48 324 194703 184038 79365323
Diabetic ketoacidosis 19.84 9.48 33 194994 34089 79515272
Drug ineffective for unapproved indication 19.78 9.48 202 194825 51036 79498325
Inappropriate antidiuretic hormone secretion 19.76 9.48 121 194906 26192 79523169
Aeromonas infection 19.75 9.48 12 195015 364 79548997
Influenza 19.73 9.48 212 194815 129394 79419967
Hepatitis infectious mononucleosis 19.72 9.48 9 195018 149 79549212
Intestinal stenosis 19.70 9.48 34 194993 3720 79545641
Post infection glomerulonephritis 19.70 9.48 8 195019 98 79549263
Rectal tube insertion 19.61 9.48 5 195022 10 79549351
Haemorrhagic vasculitis 19.55 9.48 8 195019 100 79549261
Ligament disorder 19.54 9.48 12 195015 371 79548990
Neoplasm progression 19.54 9.48 63 194964 51619 79497742
Bronchiectasis 19.45 9.48 107 194920 22279 79527082
Headache 19.45 9.48 1357 193670 652415 78896946
Myoclonus 19.41 9.48 125 194902 27535 79521826
Dyspnoea 19.37 9.48 1819 193208 855206 78694155
Chronic gastrointestinal bleeding 19.36 9.48 13 195014 470 79548891
Bronchial disorder 19.31 9.48 27 195000 2462 79546899
Sudden death 19.29 9.48 16 195011 22495 79526866
Uveitis 19.28 9.48 87 194940 16743 79532618
Leukocyturia 19.23 9.48 24 195003 1959 79547402
Cerebral infarction 19.20 9.48 53 194974 45623 79503738
Basal cell carcinoma 19.20 9.48 39 194988 37336 79512025
Faciobrachial dystonic seizure 19.15 9.48 7 195020 63 79549298
Fear of death 19.13 9.48 21 195006 1495 79547866
Staphylococcal sepsis 19.08 9.48 79 194948 14647 79534714
Myopathy 19.03 9.48 100 194927 20463 79528898
Graft versus host disease 18.99 9.48 80 194947 14946 79534415
Pyelonephritis fungal 18.98 9.48 10 195017 229 79549132
Joint ankylosis 18.96 9.48 25 195002 2155 79547206
Pancytopenia 18.86 9.48 535 194492 165210 79384151
Dyslexia 18.82 9.48 10 195017 233 79549128
Hospitalisation 18.76 9.48 144 194883 94092 79455269
Troponin increased 18.69 9.48 12 195015 19243 79530118
Limb immobilisation 18.68 9.48 7 195020 68 79549293
Bacterial endophthalmitis 18.60 9.48 9 195018 171 79549190
Chemical burns of eye 18.55 9.48 8 195019 115 79549246
Face oedema 18.44 9.48 125 194902 28011 79521350
Histamine intolerance 18.37 9.48 6 195021 37 79549324
Respiratory tract infection bacterial 18.35 9.48 24 195003 2053 79547308
Cardiac arrest 18.35 9.48 303 194724 171793 79377568
Pneumonia pseudomonal 18.33 9.48 43 194984 5868 79543493
Renal injury 18.28 9.48 86 194941 16841 79532520
Vaccination site reaction 18.18 9.48 8 195019 121 79549240
Epididymitis 18.15 9.48 23 195004 1907 79547454
Rash 18.13 9.48 1646 193381 576712 78972649
Jaundice 18.12 9.48 205 194822 53144 79496217
Food allergy 18.10 9.48 63 194964 10761 79538600
Anuria 18.08 9.48 100 194927 20863 79528498
Frequent bowel movements 18.04 9.48 129 194898 29410 79519951
Small fibre neuropathy 17.92 9.48 13 195014 533 79548828
Hypercholesterolaemia 17.90 9.48 18 195009 23077 79526284
Bladder hypertrophy 17.88 9.48 14 195013 645 79548716
Spinal fracture 17.87 9.48 11 195016 18043 79531318
Hypersensitivity vasculitis 17.83 9.48 47 194980 6896 79542465
Hyperpathia 17.83 9.48 4 195023 3 79549358
Anhedonia 17.81 9.48 78 194949 14820 79534541
Pruritus genital 17.75 9.48 36 194991 4450 79544911
Irritable bowel syndrome 17.70 9.48 85 194942 62156 79487205
Corynebacterium infection 17.69 9.48 19 195008 1319 79548042
Intestinal dilatation 17.63 9.48 27 195000 2673 79546688
Mouth ulceration 17.61 9.48 157 194870 38237 79511124
C-reactive protein abnormal 17.57 9.48 60 194967 48307 79501054
Muscular weakness 17.52 9.48 516 194511 160213 79389148
Ischaemic cerebral infarction 17.47 9.48 26 195001 2509 79546852
Deafness bilateral 17.40 9.48 24 195003 2161 79547200
Biliary dyskinesia 17.40 9.48 26 195001 2519 79546842
Nail bed bleeding 17.38 9.48 14 195013 672 79548689
Generalised tonic-clonic seizure 17.37 9.48 174 194853 43736 79505625
Restlessness 17.33 9.48 182 194845 46310 79503051
Product use issue 17.29 9.48 386 194641 209436 79339925
Exercise tolerance decreased 17.12 9.48 55 194972 9016 79540345
Anal paraesthesia 17.08 9.48 5 195022 20 79549341
Necrotising retinitis 17.03 9.48 18 195009 1227 79548134
Lip erosion 16.95 9.48 20 195007 1540 79547821
Diabetes mellitus 16.95 9.48 117 194910 78273 79471088
Diabetic macroangiopathy 16.92 9.48 8 195019 144 79549217
Thermal burn 16.92 9.48 47 194980 7113 79542248
Metastases to liver 16.82 9.48 27 195000 28287 79521074
Panic reaction 16.78 9.48 36 194991 4629 79544732
SARS-CoV-2 test positive 16.78 9.48 4 195023 11712 79537649
Skin oedema 16.77 9.48 21 195006 1720 79547641
Head injury 16.74 9.48 42 194985 37327 79512034
Bacteriuria 16.72 9.48 18 195009 1253 79548108
Red blood cell count decreased 16.68 9.48 78 194949 57435 79491926
Therapy partial responder 16.67 9.48 11 195016 17386 79531975
Gastroenteritis staphylococcal 16.61 9.48 10 195017 298 79549063
Atrioventricular block complete 16.61 9.48 10 195017 16600 79532761
Hypogonadism 16.59 9.48 21 195006 1739 79547622
Dermatitis exfoliative generalised 16.59 9.48 47 194980 7194 79542167
Intestinal fistula 16.57 9.48 19 195008 1419 79547942
Proctalgia 16.54 9.48 58 194969 9943 79539418
Necrosis 16.53 9.48 56 194971 9437 79539924
May-Thurner syndrome 16.52 9.48 5 195022 23 79549338
Anorectal disorder 16.50 9.48 24 195003 2269 79547092
Sedation 16.49 9.48 68 194959 51827 79497534
International normalised ratio increased 16.44 9.48 295 194732 84426 79464935
Enterocutaneous fistula 16.31 9.48 22 195005 1939 79547422
Bursitis 16.28 9.48 40 194987 35804 79513557
Procalcitonin decreased 16.27 9.48 7 195020 100 79549261
Post transplant lymphoproliferative disorder 16.25 9.48 4 195023 11460 79537901
General physical health deterioration 16.24 9.48 531 194496 274707 79274654
Oxygen saturation decreased 16.24 9.48 220 194807 128827 79420534
Vulvovaginal swelling 16.23 9.48 11 195016 404 79548957
Infusion site streaking 16.04 9.48 12 195015 516 79548845
Gluten sensitivity 16.04 9.48 11 195016 412 79548949
Bladder trabeculation 16.04 9.48 6 195021 58 79549303
Joint range of motion decreased 16.03 9.48 36 194991 33246 79516115
Swelling face 16.03 9.48 254 194773 70958 79478403
Subdural haematoma 15.97 9.48 33 194994 31401 79517960
Necrotising scleritis 15.95 9.48 9 195018 237 79549124
Gastroenteritis pseudomonas 15.94 9.48 6 195021 59 79549302
Acute psychosis 15.90 9.48 33 194994 4147 79545214
Leukopenia 15.83 9.48 385 194642 116128 79433233
Systemic candida 15.83 9.48 44 194983 6662 79542699
Cardiac disorder 15.82 9.48 95 194932 65662 79483699
Therapy non-responder 15.70 9.48 147 194880 92158 79457203
Blood pressure increased 15.70 9.48 395 194632 210965 79338396
Intestinal intraepithelial lymphocytes increased 15.64 9.48 8 195019 172 79549189
Withdrawal syndrome 15.59 9.48 26 195001 26828 79522533
Knee arthroplasty 15.47 9.48 54 194973 43194 79506167
Dysaesthesia 15.44 9.48 40 194987 5808 79543553
Adverse drug reaction 15.41 9.48 97 194930 66295 79483066
Cytokine release syndrome 15.40 9.48 145 194882 35853 79513508
Adverse reaction 15.39 9.48 54 194973 9260 79540101
Idiopathic intracranial hypertension 15.38 9.48 28 194999 3194 79546167
Product contamination microbial 15.35 9.48 15 195012 931 79548430
Prothrombin time shortened 15.34 9.48 28 194999 3200 79546161
White blood cell count decreased 15.33 9.48 347 194680 187941 79361420
Mucosal hyperaemia 15.27 9.48 6 195021 67 79549294
Tongue geographic 15.27 9.48 6 195021 67 79549294
Hypoglossal nerve paresis 15.22 9.48 7 195020 118 79549243
Gastrointestinal scarring 15.18 9.48 10 195017 350 79549011
Tachypnoea 15.17 9.48 132 194895 31931 79517430
Lymphadenectomy 15.13 9.48 17 195010 1242 79548119
Intrauterine infection 15.11 9.48 6 195021 69 79549292
C-reactive protein decreased 15.11 9.48 25 195002 2643 79546718
Swollen tongue 15.10 9.48 165 194862 42405 79506956
Device related infection 15.10 9.48 139 194888 34155 79515206
Injury 15.09 9.48 270 194757 77226 79472135
Neurotransmitter level altered 15.08 9.48 4 195023 10 79549351
Injection site joint erythema 15.05 9.48 3 195024 0 79549361
Inflammatory marker increased 15.02 9.48 59 194968 10681 79538680
Respiratory arrest 15.00 9.48 81 194946 57469 79491892
Proctitis 14.98 9.48 42 194985 6390 79542971
Plantar fascial fibromatosis 14.89 9.48 5 195022 34 79549327
Anal skin tags 14.85 9.48 11 195016 466 79548895
Rash macular 14.74 9.48 121 194906 28778 79520583
Anxiety disorder 14.70 9.48 32 194995 4155 79545206
Liver function test increased 14.68 9.48 49 194978 39724 79509637
Immunodeficiency 14.66 9.48 19 195008 21749 79527612
Enterobiasis 14.65 9.48 5 195022 36 79549325
Factor XIII Inhibition 14.65 9.48 5 195022 36 79549325
Oral candidiasis 14.55 9.48 123 194904 29505 79519856
Chronic kidney disease 14.53 9.48 235 194792 65919 79483442
Botulism 14.43 9.48 10 195017 381 79548980
Neurotoxicity 14.42 9.48 132 194895 32386 79516975
Fusarium infection 14.40 9.48 20 195007 1812 79547549
Skin test positive 14.36 9.48 16 195011 1158 79548203
Lupus-like syndrome 14.34 9.48 8 195019 13849 79535512
Disease complication 14.33 9.48 35 194992 4902 79544459
Renal cancer 14.27 9.48 6 195021 12220 79537141
Hepatotoxicity 14.26 9.48 190 194837 51162 79498199
Vulvovaginal pain 14.25 9.48 22 195005 2193 79547168
Rectal tenesmus 14.25 9.48 19 195008 1656 79547705
Ankylosing spondylitis 14.22 9.48 6 195021 12199 79537162
Kounis syndrome 14.22 9.48 32 194995 4250 79545111
Coeliac disease 14.19 9.48 5 195022 11346 79538015
Stomatococcal infection 14.16 9.48 9 195018 296 79549065
Retinitis viral 14.14 9.48 7 195020 140 79549221
Blood creatine increased 14.09 9.48 53 194974 9402 79539959
Rhabdomyolysis 14.08 9.48 341 194686 102790 79446571
Pseudomonal sepsis 14.07 9.48 40 194987 6134 79543227
Pain in extremity 14.05 9.48 1054 193973 363484 79185877
Peripheral venous disease 14.01 9.48 11 195016 15898 79533463
Myelosuppression 13.96 9.48 51 194976 40245 79509116
Treatment noncompliance 13.94 9.48 73 194954 52195 79497166
Incorrect dose administered 13.93 9.48 120 194907 76510 79472851
Deficiency of bile secretion 13.88 9.48 5 195022 43 79549318
Epilepsy 13.87 9.48 157 194870 40703 79508658
Endocarditis 13.85 9.48 57 194970 10540 79538821
Eye infection fungal 13.84 9.48 11 195016 518 79548843
Glycosylated haemoglobin increased 13.83 9.48 16 195011 19244 79530117
Drain placement 13.79 9.48 7 195020 148 79549213
Cataract 13.79 9.48 92 194935 62028 79487333
Accidental overdose 13.78 9.48 50 194977 39531 79509830
Activated partial thromboplastin time prolonged 13.73 9.48 70 194957 14158 79535203
Faecal calprotectin increased 13.72 9.48 37 194990 5504 79543857
Myocardial ischaemia 13.65 9.48 26 195001 25493 79523868
Hypersensitivity 13.62 9.48 514 194513 261725 79287636
Gastric cancer 13.58 9.48 4 195023 10175 79539186
Probiotic therapy 13.58 9.48 7 195020 153 79549208
Seroconversion test positive 13.58 9.48 5 195022 46 79549315
Carcinoembryonic antigen 13.56 9.48 6 195021 92 79549269
Fungal infection 13.54 9.48 159 194868 41589 79507772
Scrotal oedema 13.52 9.48 18 195009 1567 79547794
Fatigue 13.49 9.48 2032 192995 927695 78621666
Enterocolonic fistula 13.42 9.48 7 195020 157 79549204
Carbohydrate antigen 15-3 13.39 9.48 6 195021 95 79549266
Metabolic disorder 13.33 9.48 51 194976 9119 79540242
Vaginal infection 13.31 9.48 38 194989 5842 79543519
Pyuria 13.27 9.48 22 195005 2330 79547031
Bovine tuberculosis 13.26 9.48 7 195020 161 79549200
Arterial angioplasty 13.21 9.48 5 195022 50 79549311
Osteolysis 13.17 9.48 32 194995 4466 79544895
Rhinalgia 13.16 9.48 22 195005 2345 79547016
Anorectal discomfort 13.14 9.48 28 194999 3583 79545778
Neutropenic sepsis 13.11 9.48 112 194915 26952 79522409
Vaginal flatulence 13.09 9.48 23 195004 2552 79546809
Increased viscosity of bronchial secretion 13.05 9.48 11 195016 563 79548798
Type IV hypersensitivity reaction 13.00 9.48 30 194997 4051 79545310
Exfoliative rash 12.99 9.48 29 194998 3830 79545531
Loss of consciousness 12.98 9.48 312 194715 167631 79381730
Aeromonas test positive 12.98 9.48 3 195024 3 79549358
Arthritis gonococcal 12.98 9.48 3 195024 3 79549358
Vertebral artery hypoplasia 12.98 9.48 3 195024 3 79549358
Eyelid oedema 12.97 9.48 67 194960 13620 79535741
Peritoneal adhesions 12.92 9.48 9 195018 346 79549015
Needle issue 12.88 9.48 8 195019 13060 79536301
Peripheral nerve injury 12.88 9.48 12 195015 702 79548659
Gastrointestinal pain 12.87 9.48 53 194974 9802 79539559
Grip strength decreased 12.86 9.48 21 195006 21848 79527513
Haemolytic anaemia 12.79 9.48 81 194946 17739 79531622
Visual snow syndrome 12.79 9.48 5 195022 55 79549306
Clostridium colitis 12.71 9.48 24 195003 2815 79546546
Infrequent bowel movements 12.71 9.48 18 195009 1661 79547700
Pelvic fracture 12.70 9.48 7 195020 12197 79537164
Psoas abscess 12.68 9.48 14 195013 1003 79548358
Angina unstable 12.68 9.48 13 195014 16514 79532847
Axonal neuropathy 12.66 9.48 20 195007 2034 79547327
Arthralgia 12.66 9.48 1590 193437 570213 78979148
Respiratory tract oedema 12.61 9.48 13 195014 861 79548500
Enterovesical fistula 12.59 9.48 15 195012 1167 79548194
Purple glove syndrome 12.56 9.48 8 195019 264 79549097
Acid base balance abnormal 12.54 9.48 9 195018 363 79548998
Haemorrhage urinary tract 12.54 9.48 22 195005 2439 79546922
Tremor 12.52 9.48 522 194505 169561 79379800
Organic brain syndrome 12.52 9.48 10 195017 474 79548887
Device issue 12.51 9.48 30 194997 27078 79522283
Facet joint syndrome 12.48 9.48 6 195021 11296 79538065
Glare 12.45 9.48 6 195021 113 79549248
Nervousness 12.45 9.48 41 194986 33374 79515987
Autonomic neuropathy 12.44 9.48 19 195008 1876 79547485
Lactic acidosis 12.42 9.48 111 194916 70248 79479113
Osteopenia 12.40 9.48 16 195011 18348 79531013
Performance status decreased 12.40 9.48 38 194989 6075 79543286
Stenotrophomonas test positive 12.34 9.48 9 195018 372 79548989
Drug level below therapeutic 12.33 9.48 52 194975 9718 79539643
Arthritis 12.33 9.48 202 194825 114678 79434683
Dehydration 12.30 9.48 733 194294 247454 79301907
Colorectal cancer 12.29 9.48 3 195024 8644 79540717
Left ventricular hypertrophy 12.26 9.48 6 195021 11185 79538176
Faecal volume decreased 12.25 9.48 7 195020 189 79549172
Herpes zoster meningoencephalitis 12.23 9.48 12 195015 749 79548612
Product storage error 12.18 9.48 13 195014 16213 79533148
Organ failure 12.14 9.48 29 194998 4004 79545357
Muscle discomfort 12.12 9.48 8 195019 281 79549080
Pulmonary fibrosis 12.11 9.48 61 194966 44051 79505310
Vision blurred 12.09 9.48 342 194685 105556 79443805
Gastrointestinal haemorrhage 12.09 9.48 272 194755 147447 79401914
Product complaint 12.05 9.48 9 195018 13340 79536021
Cardiac murmur 12.03 9.48 73 194954 15751 79533610
Cerebellar syndrome 12.00 9.48 35 194992 5445 79543916
Clostridium bacteraemia 11.99 9.48 9 195018 389 79548972
Ligament rupture 11.99 9.48 26 195001 3368 79545993
Pain 11.99 9.48 1523 193504 702279 78847082
Neuropsychiatric symptoms 11.96 9.48 16 195011 1399 79547962
Renal pain 11.94 9.48 46 194981 8250 79541111
Overgrowth bacterial 11.92 9.48 7 195020 199 79549162
Progressive multifocal leukoencephalopathy 11.91 9.48 20 195007 20580 79528781
Colour blindness acquired 11.90 9.48 6 195021 125 79549236
Cryptitis 11.90 9.48 8 195019 290 79549071
Tonsillar haemorrhage 11.90 9.48 8 195019 290 79549071
Apoptosis 11.89 9.48 10 195017 510 79548851
Therapeutic response unexpected 11.87 9.48 19 195008 19927 79529434
Renal abscess 11.86 9.48 14 195013 1079 79548282
Abortion spontaneous 11.84 9.48 35 194992 29472 79519889
Skin exfoliation 11.83 9.48 195 194832 54905 79494456
Mitochondrial enzyme deficiency 11.81 9.48 4 195023 28 79549333
Basophil count abnormal 11.81 9.48 4 195023 28 79549333
Bone cyst 11.79 9.48 26 195001 3407 79545954
Penile blister 11.78 9.48 5 195022 69 79549292
Rhinorrhoea 11.75 9.48 124 194903 75950 79473411
Throat tightness 11.73 9.48 112 194915 27795 79521566
Vascular access site pain 11.73 9.48 6 195021 129 79549232
Groin pain 11.69 9.48 63 194964 13017 79536344
Painful respiration 11.68 9.48 26 195001 3427 79545934
Full blood count abnormal 11.67 9.48 55 194972 40419 79508942
Device leakage 11.63 9.48 6 195021 10850 79538511
Periorbital oedema 11.62 9.48 46 194981 8356 79541005
Cognitive disorder 11.62 9.48 112 194915 69814 79479547
Inflammation 11.62 9.48 306 194721 93447 79455914
Resuscitation 11.62 9.48 21 195006 2383 79546978
Prostate cancer 11.59 9.48 42 194985 33226 79516135
Colonic fistula 11.56 9.48 11 195016 661 79548700
Bacteraemia 11.54 9.48 127 194900 32697 79516664
Peripheral arterial occlusive disease 11.48 9.48 3 195024 8255 79541106
Ototoxicity 11.47 9.48 25 195002 3249 79546112
Miosis 11.46 9.48 13 195014 15776 79533585
Microbiology test abnormal 11.45 9.48 3 195024 7 79549354
Musculoskeletal stiffness 11.45 9.48 333 194694 174675 79374686
Tooth fracture 11.45 9.48 7 195020 11523 79537838
Palmar-plantar erythrodysaesthesia syndrome 11.44 9.48 42 194985 33092 79516269
Bundle branch block left 11.42 9.48 7 195020 11506 79537855
Creatinine renal clearance decreased 11.40 9.48 18 195009 18984 79530377
Penile oedema 11.40 9.48 8 195019 311 79549050
Large intestinal stenosis 11.40 9.48 23 195004 2833 79546528
Burning mouth syndrome 11.36 9.48 10 195017 543 79548818
Microvillous inclusion disease 11.35 9.48 7 195020 218 79549143
Complex regional pain syndrome 11.34 9.48 19 195008 2029 79547332
Mucous stools 11.33 9.48 33 194994 5129 79544232
Rash papular 11.31 9.48 92 194935 21824 79527537
Lower limb fracture 11.27 9.48 25 195002 23190 79526171
Candida osteomyelitis 11.25 9.48 4 195023 33 79549328
Injection site haemorrhage 11.23 9.48 33 194994 27837 79521524
Gastrointestinal disorder 11.18 9.48 221 194806 121984 79427377
Chromaturia 11.16 9.48 104 194923 25642 79523719
Injection site urticaria 11.13 9.48 9 195018 12817 79536544
Hyperchlorhydria 11.13 9.48 19 195008 2060 79547301
Joint instability 11.09 9.48 16 195011 1502 79547859
Arrhythmia 11.07 9.48 211 194816 61061 79488300
Hepatic steatosis 11.05 9.48 141 194886 37597 79511764
Burnout syndrome 11.03 9.48 8 195019 328 79549033
Parosmia 11.02 9.48 40 194987 6974 79542387
Pruritus 10.98 9.48 1114 193913 393534 79155827
Blood bilirubin increased 10.93 9.48 225 194802 66007 79483354
Urine odour abnormal 10.92 9.48 37 194990 6236 79543125
Roseola 10.91 9.48 3 195024 9 79549352
Respiratory tract inflammation 10.91 9.48 12 195015 856 79548505
Internal haemorrhage 10.86 9.48 4 195023 8829 79540532
Malignant melanoma 10.85 9.48 12 195015 14729 79534632
Penile erythema 10.84 9.48 6 195021 152 79549209
Actinic keratosis 10.84 9.48 36 194991 6006 79543355
Calculus bladder 10.82 9.48 15 195012 1357 79548004
Encephalopathy 10.81 9.48 228 194799 67169 79482192
Injection site rash 10.78 9.48 17 195010 17937 79531424
Cardiac failure chronic 10.72 9.48 7 195020 11128 79538233
Tongue disorder 10.71 9.48 11 195016 13964 79535397
Sense of oppression 10.71 9.48 16 195011 1550 79547811
Nephropathy toxic 10.69 9.48 86 194941 20333 79529028
Tongue coated 10.68 9.48 15 195012 1374 79547987
Metatarsal excision 10.67 9.48 3 195024 10 79549351
Orchitis noninfective 10.67 9.48 3 195024 10 79549351
Occupational exposure to air contaminants 10.63 9.48 6 195021 158 79549203
Joint injury 10.63 9.48 40 194987 31295 79518066
Hypercreatininaemia 10.62 9.48 13 195014 1040 79548321
Hypoxia 10.60 9.48 183 194844 103060 79446301
Procalcitonin increased 10.59 9.48 23 195004 2983 79546378
Glomerular filtration rate decreased 10.58 9.48 25 195002 22677 79526684
Keratitis bacterial 10.57 9.48 6 195021 160 79549201
Colonic abscess 10.51 9.48 15 195012 1394 79547967
Product dose omission in error 10.50 9.48 3 195024 7785 79541576
Epicondylitis 10.49 9.48 19 195008 2159 79547202
Herpes simplex colitis 10.48 9.48 4 195023 41 79549320
Multiple-drug resistance 10.44 9.48 46 194981 8762 79540599
Petechiae 10.43 9.48 86 194941 20479 79528882
Lip swelling 10.40 9.48 149 194878 40762 79508599
Prolapse 10.40 9.48 4 195023 42 79549319
Urinary tract infection pseudomonal 10.39 9.48 17 195010 1781 79547580
Pleural neoplasm 10.38 9.48 8 195019 360 79549001
Culture stool positive 10.37 9.48 10 195017 611 79548750
Bladder cancer 10.35 9.48 20 195007 19506 79529855
Perineal pain 10.34 9.48 13 195014 1069 79548292
Diabetes mellitus inadequate control 10.31 9.48 28 194999 24236 79525125
Dyslipidaemia 10.30 9.48 8 195019 11625 79537736
Hypoacusis 10.30 9.48 116 194911 30034 79519327
Biopsy colon abnormal 10.29 9.48 5 195022 96 79549265
Paranasal sinus discomfort 10.28 9.48 29 194998 4427 79544934
Gynaecomastia 10.28 9.48 3 195024 7678 79541683
Papilloma 10.26 9.48 8 195019 366 79548995
Infective exacerbation of bronchiectasis 10.25 9.48 11 195016 763 79548598
Aural polyp 10.24 9.48 5 195022 97 79549264
Incision site discharge 10.23 9.48 4 195023 44 79549317
Flavobacterium infection 10.19 9.48 5 195022 98 79549263
Cholecystitis acute 10.19 9.48 62 194965 13389 79535972
Urethral pain 10.16 9.48 9 195018 493 79548868
Rebound acid hypersecretion 10.15 9.48 5 195022 99 79549262
Neuroleptic malignant syndrome 10.14 9.48 34 194993 27525 79521836
Left ventricular dysfunction 10.12 9.48 20 195007 19341 79530020
Candida test positive 10.11 9.48 13 195014 1093 79548268
Urethral stenosis 10.11 9.48 13 195014 1093 79548268
Distal intestinal obstruction syndrome 10.10 9.48 11 195016 776 79548585
Peritonitis 10.10 9.48 109 194918 27927 79521434
Subacute cutaneous lupus erythematosus 10.07 9.48 25 195002 3536 79545825
Convulsive threshold lowered 10.06 9.48 12 195015 935 79548426
Presyncope 10.04 9.48 59 194968 40995 79508366
Cardiac discomfort 10.03 9.48 14 195013 1274 79548087
Diarrhoea haemorrhagic 10.03 9.48 61 194966 13173 79536188
Pseudomonas test positive 10.02 9.48 17 195010 1835 79547526
Infection 9.99 9.48 486 194541 241226 79308135
White blood cells urine 9.99 9.48 9 195018 504 79548857
Angiopathy 9.98 9.48 39 194988 7043 79542318
Administration site swelling 9.96 9.48 9 195018 506 79548855
Testicular pain 9.93 9.48 18 195009 2047 79547314
Injection site streaking 9.92 9.48 4 195023 48 79549313
Blood calcium decreased 9.92 9.48 42 194985 31777 79517584
Lung disorder 9.89 9.48 138 194889 80419 79468942
Aphthous ulcer 9.88 9.48 73 194954 16816 79532545
Vipoma 9.88 9.48 3 195024 14 79549347
Finger deformity 9.86 9.48 3 195024 7471 79541890
Ligament injury 9.85 9.48 13 195014 1122 79548239
Sitting disability 9.84 9.48 8 195019 389 79548972
Hepatic amoebiasis 9.84 9.48 5 195022 106 79549255
Genital pain 9.79 9.48 11 195016 803 79548558
Platelet count decreased 9.78 9.48 383 194644 194281 79355080
Genital paraesthesia 9.78 9.48 4 195023 50 79549311
Adjustment disorder with depressed mood 9.76 9.48 5 195022 9081 79540280
Vulvovaginal candidiasis 9.74 9.48 20 195007 2494 79546867
Labelled drug-drug interaction medication error 9.73 9.48 107 194920 27543 79521818
Onychomycosis 9.73 9.48 4 195023 8257 79541104
Lower respiratory tract infection 9.72 9.48 241 194786 128979 79420382
Suspected suicide 9.72 9.48 7 195020 10569 79538792
Blood catecholamines decreased 9.71 9.48 3 195024 15 79549346
Gallbladder rupture 9.71 9.48 12 195015 970 79548391
Altered state of consciousness 9.67 9.48 65 194962 43757 79505604
Chills 9.67 9.48 482 194545 159752 79389609
Gallbladder polyp 9.63 9.48 12 195015 978 79548383
Post procedural infection 9.62 9.48 54 194973 11330 79538031
Irritability 9.61 9.48 60 194967 41084 79508277
Interstitial lung disease 9.60 9.48 206 194821 112394 79436967
Glomerulonephritis acute 9.59 9.48 7 195020 290 79549071
Vaginal abscess 9.58 9.48 8 195019 404 79548957
Wound drainage 9.57 9.48 13 195014 1153 79548208
Intentional product use issue 9.56 9.48 291 194736 151821 79397540
Akathisia 9.54 9.48 11 195016 13248 79536113
Hypercalcaemia 9.52 9.48 55 194972 38375 79510986
Increased tendency to bruise 9.52 9.48 7 195020 10457 79538904

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01MA02 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
QUINOLONE ANTIBACTERIALS
Fluoroquinolones
ATC J01RA10 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
COMBINATIONS OF ANTIBACTERIALS
Combinations of antibacterials
ATC J01RA11 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
COMBINATIONS OF ANTIBACTERIALS
Combinations of antibacterials
ATC J01RA12 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
COMBINATIONS OF ANTIBACTERIALS
Combinations of antibacterials
ATC S01AE03 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Fluoroquinolones
ATC S02AA15 SENSORY ORGANS
OTOLOGICALS
ANTIINFECTIVES
Antiinfectives
ATC S03AA07 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
ANTIINFECTIVES
Antiinfectives
FDA CS M0023650 Quinolones
FDA CS M0372253 Fluoroquinolones
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D065609 Cytochrome P-450 CYP1A2 Inhibitors
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D059005 Topoisomerase II Inhibitors
MeSH PA D059003 Topoisomerase Inhibitors
FDA EPC N0000175937 Quinolone Antimicrobial
FDA MoA N0000182138 Cytochrome P450 1A2 Inhibitors
FDA EPC N0000193223 Fluoroquinolone Antibacterial
CHEBI has role CHEBI:35441 antiinfective agents
CHEBI has role CHEBI:36047 antibacterial drugs
CHEBI has role CHEBI:50750 inhibitors of type II topoisomerase
CHEBI has role CHEBI:53559 topoisomerase IV inhibitors
CHEBI has role CHEBI:33281 antibiotics
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:59517 DNA synthesis inhibitors
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Otitis externa indication 3135009
Typhoid fever indication 4834000 DOID:13258
Septicemia due to Escherichia coli indication 9323009
Prostatitis indication 9713002 DOID:14654
Infection due to Pseudomonas aeruginosa indication 11218009
Enteric campylobacteriosis indication 18081009
Infectious diarrheal disease indication 19213003 DOID:13250
Infection of skin AND/OR subcutaneous tissue indication 19824006
Acute gonococcal cervicitis indication 20943002 DOID:10615
Acute gonococcal urethritis indication 29864006
Acute bacterial peritonitis indication 31860008
Pneumonia due to Streptococcus indication 34020007
Shigellosis indication 36188001
Cystitis indication 38822007 DOID:1679
Pneumonia due to Pseudomonas indication 41381004
Lower respiratory tract infection indication 50417007
Pneumonia due to Escherichia coli indication 51530003
Bacterial pneumonia indication 53084003 DOID:874
Klebsiella cystitis indication 60867007
Acute maxillary sinusitis indication 68272006 DOID:2050
Haemophilus influenzae pneumonia indication 70036007
Infection due to Escherichia coli indication 71057007
Rhinoscleroma indication 72409005 DOID:11336
Abdominal abscess indication 75100008
Acute bacterial sinusitis indication 75498004
Infective otitis externa indication 86981007 DOID:9463
Infection of bone indication 111253001
Infectious disease of abdomen indication 128070006
Bacterial conjunctivitis indication 128350005 DOID:9700
Infection due to Enterobacteriaceae indication 128945009
Bacterial infection due to Klebsiella pneumoniae indication 186435004
Acute Moraxella catarrhalis bronchitis indication 195722003
Proteus pneumonia indication 195888009
Malignant otitis externa due to Pseudomonas aeruginosa indication 232230009
Acute bacterial bronchitis indication 233598009
Infective cystitis indication 236620008
Chancroid indication 266143009 DOID:13778
Escherichia coli urinary tract infection indication 301011002
Proteus urinary tract infection indication 301012009
Streptococcus pyogenes infection indication 302809008
Bacterial urinary infection indication 312124009
Infective otitis media indication 312218008
Infectious disorder of joint indication 363162000
Infection due to Staphylococcus aureus indication 406602003
Anthrax indication 409498004 DOID:7427
Acute osteomyelitis indication 409780002
Nosocomial pneumonia indication 425464007
Urinary tract infection caused by Klebsiella indication 369001000119100
Skin and Skin Structure Pseudomonas Aeruginosa Infection indication
Complicated UTI with Pseudomonas Aeruginosa indication
Staphylococcus Epidermidis Urinary Tract Infection indication
Pseudomonas Aeruginosa Joint Infection indication
Complicated Proteus UTI indication
Skin and Skin Structure Providencia Infection indication
Complicated Bacterial Peritonitis indication
Staphylococcus Saprophyticus Urinary Tract Infection indication
Haemophilus Parainfluenzae Pneumonia indication
Enterobacter Pneumonia indication
Skin and Skin Structure Citrobacter Infection indication
Moraxella Catarrhalis Chronic Bronchitis indication
Diarrhea due to E. Coli indication
Klebsiella Nosocomial Pneumonia indication
Citrobacter Urinary Tract Infection indication
Enterococcus Urinary Tract Infection indication
Serratia Joint Infection indication
Skin and Skin Structure Proteus Infection indication
EnterobacterJoint Infection indication
Enterobacter Osteomyelitis indication
Nosocomial Pneumonia due to Haemophilus Influenzae indication
Complicated Bacteroides Peritonitis indication
Complicated E. Coli Peritonitis indication
Morganella Morganii Urinary Tract Infection indication
Bacterial Corneal Ulcer Infection indication
E. Coli Cystitis indication
Staphylococcus Aureus Otitis Externa indication
Staphylococcus Cystitis indication
Chronic Bacterial Prostatitis indication
Pseudomonas Aeruginosa Urinary Tract Infection indication
Gram-Negative Aerobic Bacillary Pneumonia indication
Serratia Osteomyelitis indication
Staphylococcus Epidermidis Skin and Skin Structure Infection indication
Enterococcus Complicated UTI indication
Providencia Urinary Tract Infection indication
Complicated Klebsiella Peritonitis indication
Skin and Skin Structure Serratia Infection indication
Proteus Prostatitis indication
E. Coli Pyelonephritis indication
Skin and Skin Structure Morganella Morganii Infection indication
Serratia Urinary Tract Infection indication
Pseudomonas Aeruginosa Osteomyelitis indication
Inhalational anthrax off-label use 11389007
Traveler's diarrhea off-label use 11840006
Salmonella septicemia off-label use 49786009
Cutaneous anthrax off-label use 84980006 DOID:7426
Gastrointestinal anthrax off-label use 111798006 DOID:13386
Diverticulitis of gastrointestinal tract off-label use 271366000
Ventilator-acquired pneumonia off-label use 429271009
Diabetic Foot Infection off-label use
Prevention of Meningococcal Meningitis off-label use
Achilles tendinitis contraindication 11654001
Lowered convulsive threshold contraindication 19260006
Torsades de pointes contraindication 31722008
Transplantation of heart contraindication 32413006
Tendinitis contraindication 34840004 DOID:971
Hypokalemia contraindication 43339004
Transplant of kidney contraindication 70536003
Epilepsy contraindication 84757009 DOID:1826
Transplant of lung contraindication 88039007
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Prolonged QT interval contraindication 111975006
Superimposed infection contraindication 193198003
Peripheral nerve disease contraindication 302226006
Viral ear infection contraindication 312137007
Pseudomembranous enterocolitis contraindication 397683000
Traumatic rupture of tendon contraindication 415749005
Congenital long QT syndrome contraindication 442917000
Shoulder Tendonitis contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.12 acidic
pKa2 8.54 Basic
pKa3 1.37 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.3%;0.1% CIPRODEX NOVARTIS N021537 July 18, 2003 RX SUSPENSION/DROPS OTIC 8846650 June 4, 2025 TREATMENT OF ACUTE OTITIS MEDIA
6% (60MG/ML) OTIPRIO ALK ABELLO N207986 Dec. 10, 2015 DISCN INJECTABLE, SUSPENSION OTIC 9205048 April 21, 2029 TREATMENT OF PEDIATRIC PATIENTS WITH OTITIS MEDIA WITH EFFUSION UNDERGOING TYMPANOSTOMY TUBE PLACEMENT
6% (60MG/ML) OTIPRIO ALK ABELLO N207986 Dec. 10, 2015 DISCN INJECTABLE, SUSPENSION OTIC 9603796 April 21, 2029 THE TREATMENT OF ACUTE OTITIS EXTERNA IN PATIENTS 6 MONTHS OF AGE AND OLDER DUE TO PSEUDOMONAS AERUGINOSA AND STAPHYLOCOCCUS AUREUS
EQ 0.3% BASE;0.025% OTOVEL LABORATORIOS SALVAT N208251 April 29, 2016 RX SOLUTION/DROPS OTIC 8932610 March 24, 2030 TREATMENT OF ACUTE OTITIS MEDIA
6% (60MG/ML) OTIPRIO ALK ABELLO N207986 Dec. 10, 2015 DISCN INJECTABLE, SUSPENSION OTIC 8318817 April 27, 2030 TREATMENT OF OTIC INFECTION OR INFLAMMATION
6% (60MG/ML) OTIPRIO ALK ABELLO N207986 Dec. 10, 2015 DISCN INJECTABLE, SUSPENSION OTIC 11040004 Nov. 12, 2037 THE TREATMENT OF ACUTE OTITIS EXTERNA IN PATIENTS 6 MONTHS OF AGE AND OLDER DUE TO PSEUDOMONAS AERUGINOSA AND STAPHYLOCOCCUS AUREUS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
DNA topoisomerase II Enzyme EC50 7.52 CHEMBL
DNA gyrase subunit A Enzyme INHIBITOR IC50 5.75 WOMBAT-PK CHEMBL
DNA topoisomerase 4 subunit A Enzyme IC50 5.66 WOMBAT-PK
DNA topoisomerase 4 subunit A Enzyme INHIBITOR IC50 6 WOMBAT-PK
DNA gyrase subunit A Enzyme IC50 6.20 WOMBAT-PK
Histamine H3 receptor GPCR Ki 9.18 CHEMBL
GABA-A receptor; anion channel Ion channel IC50 6.39 CHEMBL
DNA topoisomerase 4 subunit A Enzyme IC50 5.60 WOMBAT-PK
Multidrug resistance protein mdtK Unclassified Kd 4.04 CHEMBL

External reference:

IDSource
4019307 VUID
N0000147503 NUI
D00186 KEGG_DRUG
86393-32-0 SECONDARY_CAS_RN
235851 RXNORM
4019306 VANDF
4019307 VANDF
C0008809 UMLSCUI
CHEBI:100241 CHEBI
CPF PDB_CHEM_ID
CHEMBL8 ChEMBL_ID
DB00537 DRUGBANK_ID
CHEMBL1202 ChEMBL_ID
D002939 MESH_DESCRIPTOR_UI
2764 PUBCHEM_CID
10902 IUPHAR_LIGAND_ID
5446 INN_ID
97867-33-9 SECONDARY_CAS_RN
5E8K9I0O4U UNII
31644 MMSL
4451 MMSL
4452 MMSL
46904 MMSL
76342 MMSL
d00011 MMSL
002882 NDDF
003577 NDDF
004125 NDDF
20450009 SNOMEDCT_US
372840008 SNOMEDCT_US
428384006 SNOMEDCT_US
7577004 SNOMEDCT_US
CHEMBL1077975 ChEMBL_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ciloxan HUMAN PRESCRIPTION DRUG LABEL 1 0065-0656 SOLUTION/ DROPS 3 mg OPHTHALMIC NDA 21 sections
Ciloxan HUMAN PRESCRIPTION DRUG LABEL 1 0065-0656 SOLUTION/ DROPS 3 mg OPHTHALMIC NDA 21 sections
CIPROHC HUMAN PRESCRIPTION DRUG LABEL 2 0065-8531 SUSPENSION 2 mg AURICULAR (OTIC) NDA 16 sections
CIPROHC HUMAN PRESCRIPTION DRUG LABEL 2 0065-8531 SUSPENSION 2 mg AURICULAR (OTIC) NDA 16 sections
CIPRODEX HUMAN PRESCRIPTION DRUG LABEL 2 0078-0799 SUSPENSION/ DROPS 3 mg AURICULAR (OTIC) NDA 28 sections
CIPRODEX HUMAN PRESCRIPTION DRUG LABEL 2 0078-0799 SUSPENSION/ DROPS 3 mg AURICULAR (OTIC) NDA 28 sections
CIPRODEX HUMAN PRESCRIPTION DRUG LABEL 2 0078-0799 SUSPENSION/ DROPS 3 mg AURICULAR (OTIC) NDA 28 sections
CILOXAN HUMAN PRESCRIPTION DRUG LABEL 1 0078-0841 OINTMENT 3 mg OPHTHALMIC NDA 20 sections
CILOXAN HUMAN PRESCRIPTION DRUG LABEL 1 0078-0841 OINTMENT 3 mg OPHTHALMIC NDA 20 sections
CILOXAN HUMAN PRESCRIPTION DRUG LABEL 1 0078-0841 OINTMENT 3 mg OPHTHALMIC NDA 20 sections
CIPROHC HUMAN PRESCRIPTION DRUG LABEL 2 0078-0855 SUSPENSION/ DROPS 2 mg AURICULAR (OTIC) NDA 16 sections
CIPROHC HUMAN PRESCRIPTION DRUG LABEL 2 0078-0855 SUSPENSION/ DROPS 2 mg AURICULAR (OTIC) NDA 16 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9927 TABLET, FILM COATED 250 mg ORAL ANDA 30 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9927 TABLET, FILM COATED 250 mg ORAL ANDA 30 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9928 TABLET, FILM COATED 500 mg ORAL ANDA 30 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9928 TABLET, FILM COATED 500 mg ORAL ANDA 30 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9929 TABLET, FILM COATED 750 mg ORAL ANDA 30 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9929 TABLET, FILM COATED 750 mg ORAL ANDA 30 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0172-5311 TABLET, FILM COATED 250 mg ORAL ANDA 29 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0172-5312 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0172-5313 TABLET, FILM COATED 750 mg ORAL ANDA 29 sections
OTIPRIO HUMAN PRESCRIPTION DRUG LABEL 1 0268-8200 SUSPENSION 60 mg INTRATYMPANIC NDA 26 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0404-7187 SOLUTION/ DROPS 3 mg OPHTHALMIC ANDA 24 sections
Ciprofloxacin in Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0409-2300 INJECTION, SOLUTION 200 mg INTRAVENOUS ANDA 33 sections
Ciprofloxacin in Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0409-3300 INJECTION, SOLUTION 400 mg INTRAVENOUS ANDA 33 sections
CIPROFLOXACIN HUMAN PRESCRIPTION DRUG LABEL 1 0409-4777 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 34 sections
CIPROFLOXACIN HUMAN PRESCRIPTION DRUG LABEL 1 0409-4777 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 34 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0615-8147 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0615-8367 TABLET, FILM COATED 500 mg ORAL ANDA 31 sections
Ciprofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0615-8367 TABLET, FILM COATED 500 mg ORAL ANDA 31 sections