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2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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Structure 🔎
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
cinnarizine 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
antihistaminics/cerebral (or peripheral) vasodilators
654
298-57-7
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
cinnarizin
cinnarizine
cinaperazine
cinarizine
cinnipirine
A piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces PARKINSONIAN DISORDERS.
Molecular weight: 368.52
Formula: C26H28N2
CLOGP: 6.05
LIPINSKI: 1
HAC: 2
HDO: 0
TPSA: 6.48
ALOGS: -5.33
ROTB: 6
Drug dosage:
Dose
Unit
Route
90
mg
O
90
mg
O
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Vestibular migraine
70.36
36.13
10
870
225
63487917
Therapeutic response changed
55.44
36.13
10
870
1035
63487107
Medication overuse headache
44.38
36.13
8
872
824
63487318
Endometrial cancer
44.21
36.13
10
870
3215
63484927
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FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Medication overuse headache
63.72
32.22
11
1075
901
79742401
Vestibular migraine
41.54
32.22
6
1080
154
79743148
Portal tract inflammation
34.71
32.22
5
1081
126
79743176
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
N07CA02
NERVOUS SYSTEM
OTHER NERVOUS SYSTEM DRUGS
ANTIVERTIGO PREPARATIONS
Antivertigo preparations
ATC
N07CA52
NERVOUS SYSTEM
OTHER NERVOUS SYSTEM DRUGS
ANTIVERTIGO PREPARATIONS
Antivertigo preparations
CHEBI has role
CHEBI:37955
H1 receptor antagonists
CHEBI has role
CHEBI:37956
antihistamines
CHEBI has role
CHEBI:38215
calcium channel blockers
CHEBI has role
CHEBI:48876
muscarinic antagonists
CHEBI has role
CHEBI:50857
anti-allergic drugs
CHEBI has role
CHEBI:50919
antiemetico
CHEBI has role
CHEBI:176497
geroprotectors
MeSH PA
D002121
Calcium Channel Blockers
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Motion sickness
indication
37031009
DOID:2951
Vertigo
indication
399153001
Nausea
indication
422587007
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
7.42
Basic
pKa2
3.42
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Mu-type opioid receptor
GPCR
P35372
OPRM_HUMAN
Ki
6.04
DRUG MATRIX
D(2) dopamine receptor
GPCR
P14416
DRD2_HUMAN
Ki
6.59
DRUG MATRIX
Alpha-2A adrenergic receptor
GPCR
P08913
ADA2A_HUMAN
Ki
6.78
DRUG MATRIX
Sigma non-opioid intracellular receptor 1
Membrane receptor
Q99720
SGMR1_HUMAN
Ki
7.77
DRUG MATRIX
Sodium-dependent serotonin transporter
Transporter
P31645
SC6A4_HUMAN
Ki
6.24
DRUG MATRIX
Sodium-dependent noradrenaline transporter
Transporter
P23975
SC6A2_HUMAN
Ki
5.55
DRUG MATRIX
5-hydroxytryptamine receptor 1A
GPCR
P08908
5HT1A_HUMAN
Ki
6.21
DRUG MATRIX
5-hydroxytryptamine receptor 2A
GPCR
P28223
5HT2A_HUMAN
Ki
6.99
DRUG MATRIX
5-hydroxytryptamine receptor 2B
GPCR
P41595
5HT2B_HUMAN
Ki
6.33
DRUG MATRIX
Alpha-2B adrenergic receptor
GPCR
P18089
ADA2B_HUMAN
Ki
5.99
DRUG MATRIX
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External reference:
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ID
Source
N90
PDB_CHEM_ID
003951
NDDF
1021
INN_ID
1547484
PUBCHEM_CID
2549
RXNORM
349958007
SNOMEDCT_US
395955001
SNOMEDCT_US
3DI2E1X18L
UNII
9072
IUPHAR_LIGAND_ID
C0008803
UMLSCUI
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Pharmaceutical products:
None
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cinnarizine