ciclesonide ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids for topical use, acetal derivatives 633 126544-47-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ciclesonide
  • omnaris
  • alvesco
nasal spray approved for seasonal and perennial allergic rhinitis
  • Molecular weight: 540.70
  • Formula: C32H44O7
  • CLOGP: 5.25
  • LIPINSKI: 2
  • HAC: 7
  • HDO: 1
  • TPSA: 99.13
  • ALOGS: -5.54
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.20 mg N
0.16 mg Inhal.aerosol

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.00 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.00 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 1 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.90 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 33.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.04 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 20, 2006 FDA TAKEDA GMBH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 2343.30 18.27 1089 27027 88248 50488760
Wheezing 1329.85 18.27 660 27456 61387 50515621
Obstructive airways disorder 972.62 18.27 355 27761 15297 50561711
Sleep disorder due to a general medical condition 590.28 18.27 202 27914 7169 50569839
Therapeutic product effect incomplete 543.62 18.27 431 27685 91084 50485924
Dyspnoea 484.82 18.27 985 27131 546623 50030385
Cough 443.27 18.27 604 27512 240660 50336348
Full blood count abnormal 433.27 18.27 226 27890 23162 50553846
Productive cough 421.69 18.27 297 27819 52397 50524611
Sputum discoloured 376.06 18.27 172 27944 13223 50563785
Forced expiratory volume decreased 361.82 18.27 123 27993 4271 50572737
Pneumonia viral 305.36 18.27 122 27994 6712 50570296
Chest discomfort 260.18 18.27 288 27828 92434 50484574
Loss of personal independence in daily activities 232.59 18.27 238 27878 69812 50507196
Soft tissue disorder 208.50 18.27 81 28035 4133 50572875
Middle insomnia 186.84 18.27 97 28019 9824 50567184
Breath sounds abnormal 175.50 18.27 86 28030 7706 50569302
Rhinitis 161.61 18.27 83 28033 8218 50568790
Arthritis 158.26 18.27 217 27899 86504 50490504
Herpes zoster 142.72 18.27 186 27930 70600 50506408
Nasal congestion 141.85 18.27 158 27958 50962 50526046
Bronchial wall thickening 139.98 18.27 41 28075 864 50576144
Sleep apnoea syndrome 131.93 18.27 108 28008 23760 50553248
Sputum purulent 116.08 18.27 36 28080 927 50576081
Blood test abnormal 109.89 18.27 72 28044 11247 50565761
Nasopharyngitis 102.44 18.27 286 27830 192641 50384367
Oral pain 97.73 18.27 93 28023 24940 50552068
Nasal polyps 95.00 18.27 40 28076 2514 50574494
Dyspnoea exertional 93.07 18.27 128 27988 51105 50525903
Bronchial neoplasm 91.34 18.27 25 28091 408 50576600
Bronchial haemorrhage 91.29 18.27 26 28090 494 50576514
Diarrhoea 89.48 18.27 118 27998 588358 49988650
Nasal turbinate hypertrophy 89.05 18.27 27 28089 643 50576365
Toxicity to various agents 88.75 18.27 8 28108 212491 50364517
Death 88.69 18.27 35 28081 325344 50251664
Influenza 87.68 18.27 169 27947 89369 50487639
Bronchial disorder 86.33 18.27 30 28086 1112 50575896
Fibromyalgia 85.68 18.27 115 28001 44863 50532145
Heart rate increased 84.62 18.27 153 27963 77097 50499911
Restrictive pulmonary disease 83.52 18.27 31 28085 1393 50575615
Glaucoma 82.54 18.27 69 28047 15617 50561391
Respiratory tract congestion 82.15 18.27 66 28050 14133 50562875
Hyper IgE syndrome 82.08 18.27 23 28093 411 50576597
Crepitations 81.79 18.27 48 28068 6171 50570837
Blood cholesterol increased 80.03 18.27 124 27992 55091 50521917
Asthma-chronic obstructive pulmonary disease overlap syndrome 80.03 18.27 23 28093 452 50576556
Acute kidney injury 79.92 18.27 15 28101 228043 50348965
Bronchiectasis 79.88 18.27 57 28059 10226 50566782
Off label use 78.50 18.27 89 28027 474337 50102671
Idiopathic intracranial hypertension 78.17 18.27 34 28082 2315 50574693
Blood immunoglobulin E increased 78.03 18.27 34 28082 2325 50574683
Bronchial secretion retention 74.54 18.27 29 28087 1484 50575524
Endometrial ablation 74.34 18.27 25 28091 838 50576170
Upper-airway cough syndrome 72.48 18.27 50 28066 8500 50568508
Kyphosis 72.42 18.27 32 28084 2263 50574745
Lung diffusion test abnormal 71.48 18.27 17 28099 152 50576856
Factor V Leiden mutation 69.50 18.27 17 28099 173 50576835
Drug interaction 68.10 18.27 14 28102 199607 50377401
Asthma exercise induced 67.94 18.27 18 28098 258 50576750
Ventricular failure 67.32 18.27 19 28097 349 50576659
Infusion related reaction 66.61 18.27 8 28108 169549 50407459
Pulmonary function test decreased 66.29 18.27 34 28082 3354 50573654
Nicotine dependence 64.53 18.27 21 28095 634 50576374
Bronchitis 62.83 18.27 162 27954 103997 50473011
Total lung capacity increased 62.38 18.27 21 28095 706 50576302
Body temperature decreased 62.26 18.27 60 28056 16335 50560673
Broncholithiasis 61.83 18.27 15 28101 147 50576861
Hepatic enzyme increased 60.63 18.27 4 28112 137376 50439632
Gastrooesophageal reflux disease 60.32 18.27 132 27984 76296 50500712
Nausea 60.09 18.27 197 27919 705201 49871807
Rhonchi 59.65 18.27 28 28088 2279 50574729
Allergy to animal 59.41 18.27 21 28095 819 50576189
Liver function test abnormal 59.30 18.27 96 28020 44243 50532765
Throat clearing 59.15 18.27 23 28093 1175 50575833
Thrombocytopenia 58.53 18.27 3 28113 127670 50449338
Respiratory disorder 58.25 18.27 79 28037 31108 50545900
Secretion discharge 57.67 18.27 46 28070 9745 50567263
Bacterial disease carrier 56.32 18.27 20 28096 791 50576217
Hypoventilation 56.18 18.27 32 28084 3889 50573119
Blood pressure systolic increased 56.16 18.27 83 28033 35366 50541642
Lymph node calcification 56.11 18.27 15 28101 223 50576785
Neutropenia 55.67 18.27 8 28108 147957 50429051
Respiratory rate increased 55.63 18.27 48 28068 11337 50565671
Pulmonary mass 55.63 18.27 60 28056 18645 50558363
Reversible airways obstruction 55.44 18.27 21 28095 999 50576009
Oropharyngeal pain 55.40 18.27 129 27987 77672 50499336
Arthropathy 54.00 18.27 11 28105 157895 50419113
Rhinitis allergic 53.83 18.27 39 28077 7161 50569847
Secondary immunodeficiency 52.33 18.27 21 28095 1167 50575841
Confusional state 52.26 18.27 19 28097 185909 50391099
Rash 51.98 18.27 103 28013 437368 50139640
Mycobacterium avium complex infection 51.27 18.27 26 28090 2504 50574504
Pneumonia 49.27 18.27 369 27747 378032 50198976
Eosinophil count increased 48.87 18.27 40 28076 8790 50568218
Chronic obstructive pulmonary disease 48.81 18.27 98 28018 53337 50523671
Hypotension 48.53 18.27 36 28080 235433 50341575
Venous pressure jugular increased 47.67 18.27 16 28100 533 50576475
Neurosensory hypoacusis 47.39 18.27 13 28103 214 50576794
Eosinophilia 47.20 18.27 55 28061 18597 50558411
Vomiting 46.95 18.27 118 27998 460640 50116368
Increased bronchial secretion 46.79 18.27 21 28095 1541 50575467
Blood pressure increased 45.60 18.27 170 27946 132962 50444046
Nasal mucosal disorder 44.65 18.27 14 28102 374 50576634
White blood cell count decreased 44.63 18.27 6 28110 116716 50460292
Nasal obstruction 44.55 18.27 18 28098 1018 50575990
Treatment failure 44.22 18.27 11 28105 137626 50439382
Humidity intolerance 43.76 18.27 13 28103 288 50576720
Polycystic ovaries 43.10 18.27 23 28093 2461 50574547
Peak expiratory flow rate decreased 42.73 18.27 15 28101 573 50576435
Rales 42.65 18.27 39 28077 9939 50567069
Alopecia 42.60 18.27 44 28072 245003 50332005
Contraindicated product administered 42.22 18.27 15 28101 148943 50428065
Glossodynia 41.75 18.27 7 28109 115562 50461446
Eczema 41.62 18.27 57 28059 22645 50554363
Therapeutic product effect decreased 41.58 18.27 12 28104 136038 50440970
Urinary tract infection 41.51 18.27 38 28078 223982 50353026
Sensitivity to weather change 41.47 18.27 31 28085 5970 50571038
Rib deformity 41.24 18.27 11 28105 162 50576846
Hand deformity 41.19 18.27 4 28112 100195 50476813
Oropharyngeal discomfort 41.04 18.27 26 28090 3832 50573176
Infection 40.70 18.27 197 27919 172757 50404251
Bronchospasm 39.60 18.27 45 28071 14809 50562199
Neuropathy peripheral 39.41 18.27 4 28112 96753 50480255
Sarcoidosis 39.40 18.27 28 28088 4989 50572019
Forced vital capacity decreased 39.27 18.27 16 28100 925 50576083
Platelet count decreased 38.93 18.27 5 28111 100721 50476287
Sinusitis 38.51 18.27 192 27924 170366 50406642
Granuloma 37.89 18.27 27 28089 4831 50572177
Hypokalaemia 37.55 18.27 3 28113 87989 50489019
Pulmonary function test abnormal 37.29 18.27 17 28099 1294 50575714
Leukopenia 36.61 18.27 101 28015 67427 50509581
Eosinophilic pneumonia chronic 36.43 18.27 10 28106 165 50576843
Respiratory tract inflammation 36.30 18.27 13 28103 527 50576481
Malaise 35.38 18.27 312 27804 335220 50241788
Viral infection 34.86 18.27 61 28055 29925 50547083
Lipohypertrophy 34.69 18.27 13 28103 600 50576408
Rheumatoid arthritis 34.48 18.27 37 28079 202513 50374495
Limb injury 34.37 18.27 49 28067 20201 50556807
Frustration tolerance decreased 34.15 18.27 27 28089 5647 50571361
Breast neoplasm 34.14 18.27 16 28100 1297 50575711
Dysphonia 33.93 18.27 70 28046 38822 50538186
Eosinophilic granulomatosis with polyangiitis 33.63 18.27 18 28098 1937 50575071
Peak expiratory flow rate abnormal 33.20 18.27 8 28108 76 50576932
Seizure 33.18 18.27 12 28104 117862 50459146
Sinus operation 33.12 18.27 17 28099 1679 50575329
Febrile neutropenia 32.97 18.27 7 28109 97660 50479348
Pericarditis 32.71 18.27 3 28113 78686 50498322
Rectal prolapse 32.63 18.27 17 28099 1732 50575276
Illness 32.62 18.27 53 28063 24487 50552521
CFTR gene mutation 32.22 18.27 8 28108 87 50576921
Emphysema 32.14 18.27 32 28084 9061 50567947
Respiratory tract infection 31.99 18.27 61 28055 31956 50545052
Affective disorder 31.93 18.27 25 28091 5156 50571852
Dehydration 31.79 18.27 23 28093 152426 50424582
Lower respiratory tract infection 31.28 18.27 120 27996 95081 50481927
Croup infectious 30.76 18.27 11 28105 444 50576564
Pancytopenia 30.55 18.27 5 28111 84025 50492983
Disease progression 30.13 18.27 8 28108 95858 50481150
Haemoglobin decreased 29.51 18.27 17 28099 127199 50449809
Granulomatosis with polyangiitis 29.36 18.27 16 28100 1784 50575224
Sepsis 29.11 18.27 19 28097 132906 50444102
Blood creatinine increased 28.91 18.27 4 28112 76156 50500852
Abdominal discomfort 28.78 18.27 53 28063 231588 50345420
Dyslipidaemia 28.76 18.27 25 28091 5963 50571045
Tenderness 28.72 18.27 43 28073 18522 50558486
Renal impairment 28.65 18.27 4 28112 75657 50501351
Respiration abnormal 27.99 18.27 23 28093 5079 50571929
Lower respiratory tract congestion 27.52 18.27 16 28100 2020 50574988
Lung disorder 27.31 18.27 70 28046 44729 50532279
Malignant neoplasm progression 27.27 18.27 3 28113 68121 50508887
Ligament pain 26.73 18.27 8 28108 182 50576826
Ankle fracture 26.62 18.27 38 28078 15684 50561324
Abscess 26.41 18.27 36 28080 14236 50562772
Weight decreased 26.07 18.27 211 27905 221034 50355974
Sinus pain 25.97 18.27 16 28100 2245 50574763
Impaired healing 25.71 18.27 4 28112 69782 50507226
Aspartate aminotransferase increased 25.50 18.27 6 28110 77992 50499016
Sinus congestion 25.49 18.27 35 28081 13936 50563072
Nocturnal dyspnoea 25.25 18.27 12 28104 1004 50576004
Rhinorrhoea 24.89 18.27 74 28042 51509 50525499
FEV1/FVC ratio decreased 24.71 18.27 6 28110 59 50576949
Peripheral swelling 24.58 18.27 197 27919 205739 50371269
Crystal arthropathy 24.54 18.27 8 28108 243 50576765
Oral candidiasis 24.50 18.27 38 28078 16877 50560131
Skin lesion 24.37 18.27 49 28067 26678 50550330
Decreased appetite 24.05 18.27 47 28069 200876 50376132
Hyponatraemia 23.53 18.27 12 28104 96127 50480881
Blister 23.52 18.27 9 28107 85409 50491599
Intentional product use issue 23.09 18.27 7 28109 76911 50500097
Soft tissue swelling 22.65 18.27 11 28105 965 50576043
Exposure to allergen 22.32 18.27 7 28109 187 50576821
Oesophagogastroduodenoscopy 22.03 18.27 6 28110 96 50576912
Pain 21.91 18.27 211 27905 578692 49998316
Pulmonary congestion 21.73 18.27 34 28082 15213 50561795
Sinus tachycardia 21.72 18.27 41 28075 21313 50555695
Pulmonary eosinophilia 21.68 18.27 7 28109 206 50576802
Alanine aminotransferase increased 21.66 18.27 11 28105 88348 50488660
Allergic sinusitis 21.31 18.27 9 28107 570 50576438
Seasonal allergy 21.30 18.27 33 28083 14643 50562365
Osteoporosis 21.29 18.27 64 28052 44815 50532193
Airway remodelling 20.61 18.27 5 28111 49 50576959
Chronic sinusitis 20.57 18.27 21 28095 6124 50570884
Forced expiratory volume 20.45 18.27 4 28112 12 50576996
Respiratory symptom 20.18 18.27 14 28102 2400 50574608
Constipation 20.08 18.27 46 28070 185662 50391346
Angioplasty 20.04 18.27 11 28105 1244 50575764
Asthmatic crisis 19.93 18.27 12 28104 1616 50575392
Eosinophil count abnormal 19.82 18.27 8 28108 451 50576557
Superinfection 19.76 18.27 13 28103 2043 50574965
Total lung capacity decreased 19.75 18.27 11 28105 1280 50575728
Lung diffusion disorder 19.54 18.27 5 28111 62 50576946
Symptom recurrence 19.49 18.27 9 28107 705 50576303
Psoriasis 19.45 18.27 7 28109 68993 50508015
Eosinophilic bronchitis 19.43 18.27 8 28108 475 50576533
Macrocytosis 19.34 18.27 13 28103 2117 50574891
Nonspecific reaction 18.95 18.27 12 28104 1767 50575241
Product dose omission issue 18.71 18.27 47 28069 183791 50393217
Exposure during pregnancy 18.55 18.27 24 28092 120991 50456017
Anti-cyclic citrullinated peptide antibody positive 18.52 18.27 8 28108 70579 50506429
Fluid retention 18.44 18.27 3 28113 50646 50526362
Smoke sensitivity 18.42 18.27 7 28109 336 50576672

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 1616.82 27.32 587 12001 33262 29528677
Wheezing 866.77 27.32 373 12215 32867 29529072
Therapeutic product effect incomplete 618.13 27.32 311 12277 38994 29522945
Obstructive airways disorder 617.78 27.32 216 12372 10800 29551139
Full blood count abnormal 489.69 27.32 198 12390 14815 29547124
Sleep disorder due to a general medical condition 337.37 27.32 101 12487 3045 29558894
Bronchiectasis 319.18 27.32 116 12472 6469 29555470
Pulmonary function test decreased 305.47 27.32 100 12488 4063 29557876
Sputum discoloured 271.76 27.32 103 12485 6460 29555479
Productive cough 252.09 27.32 160 12428 31099 29530840
Asthma-chronic obstructive pulmonary disease overlap syndrome 234.33 27.32 56 12532 687 29561252
Cough 232.15 27.32 277 12311 126450 29435489
Loss of personal independence in daily activities 229.82 27.32 140 12448 25300 29536639
Nasal congestion 194.19 27.32 113 12475 18766 29543173
Dyspnoea 192.15 27.32 425 12163 326307 29235632
Nasal obstruction 181.24 27.32 43 12545 510 29561429
Chest discomfort 177.78 27.32 151 12437 45832 29516107
Sinus pain 172.57 27.32 42 12546 559 29561380
Forced expiratory volume decreased 172.28 27.32 59 12529 2754 29559185
Breath sounds abnormal 170.91 27.32 70 12518 5387 29556552
Respiratory disorder 154.66 27.32 94 12494 16889 29545050
Eosinophil count abnormal 152.63 27.32 33 12555 248 29561691
Mycobacterium avium complex infection 117.48 27.32 42 12546 2227 29559712
Bronchial hyperreactivity 116.25 27.32 37 12551 1369 29560570
Dust allergy 109.49 27.32 28 12560 461 29561478
Nasal polyps 100.17 27.32 35 12553 1734 29560205
Eosinophil count increased 97.25 27.32 52 12536 7317 29554622
Lung consolidation 94.15 27.32 45 12543 4998 29556941
Dyspnoea exertional 89.22 27.32 93 12495 36397 29525542
Congenital hiatus hernia 87.75 27.32 23 12565 419 29561520
Vital capacity decreased 87.44 27.32 22 12566 338 29561601
Acute kidney injury 86.89 27.32 7 12581 265260 29296679
Osteopenia 86.46 27.32 40 12548 4128 29557811
Throat irritation 86.09 27.32 51 12537 8734 29553205
Seasonal allergy 84.65 27.32 42 12546 5060 29556879
Conjunctivitis allergic 83.41 27.32 24 12564 626 29561313
Influenza 82.02 27.32 95 12493 41786 29520153
Pulmonary mass 79.06 27.32 52 12536 10696 29551243
Emphysema 78.91 27.32 48 12540 8623 29553316
Spirometry abnormal 76.68 27.32 20 12568 357 29561582
Upper-airway cough syndrome 75.60 27.32 33 12555 2970 29558969
Mycotic allergy 73.50 27.32 18 12570 246 29561693
Pulmonary function test abnormal 73.07 27.32 29 12559 2053 29559886
Sinusitis 72.47 27.32 81 12507 34269 29527670
Blood immunoglobulin E increased 71.42 27.32 28 12560 1919 29560020
Mite allergy 70.23 27.32 18 12570 299 29561640
Eosinophil count 63.21 27.32 14 12574 119 29561820
Airway remodelling 61.82 27.32 14 12574 133 29561806
Vocal cord dysfunction 60.46 27.32 14 12574 148 29561791
Toxicity to various agents 58.45 27.32 4 12584 173657 29388282
Decreased activity 56.81 27.32 29 12559 3709 29558230
Lower respiratory tract infection 56.75 27.32 63 12525 26439 29535500
Death 55.68 27.32 39 12549 342045 29219894
Eye disorder 55.42 27.32 37 12551 7797 29554142
Middle insomnia 52.96 27.32 32 12556 5676 29556263
Rhinorrhoea 52.83 27.32 55 12533 21464 29540475
Suffocation feeling 52.07 27.32 16 12572 526 29561413
Pleural thickening 51.40 27.32 14 12574 297 29561642
Sensitivity to weather change 50.62 27.32 20 12568 1399 29560540
Hypoxia 50.55 27.32 80 12508 47299 29514640
Gastrooesophageal reflux disease 44.92 27.32 61 12527 31435 29530504
Nasopharyngitis 44.44 27.32 86 12502 59579 29502360
Infective exacerbation of chronic obstructive airways disease 44.37 27.32 19 12569 1631 29560308
Adrenal suppression 43.98 27.32 14 12574 518 29561421
Bronchial wall thickening 41.67 27.32 16 12572 1036 29560903
Drug interaction 41.67 27.32 16 12572 197369 29364570
Sputum increased 41.54 27.32 19 12569 1908 29560031
Bronchitis 40.35 27.32 63 12525 36805 29525134
Kidney infection 40.24 27.32 25 12563 4658 29557281
Respiratory symptom 39.68 27.32 15 12573 931 29561008
Inspiratory capacity abnormal 39.32 27.32 9 12579 90 29561849
Oesophageal polyp 39.15 27.32 8 12580 44 29561895
Respiratory rate increased 38.58 27.32 31 12557 8677 29553262
Oesophageal carcinoma 38.38 27.32 24 12564 4523 29557416
Thrombocytopenia 37.94 27.32 6 12582 134817 29427122
Respiratory tract congestion 37.63 27.32 25 12563 5224 29556715
Bronchial obstruction 37.35 27.32 16 12572 1375 29560564
Chronic sinusitis 37.29 27.32 17 12571 1694 29560245
Chronic obstructive pulmonary disease 36.76 27.32 64 12524 40891 29521048
Diarrhoea 35.86 27.32 54 12534 332644 29229295
Glaucoma 35.15 27.32 25 12563 5832 29556107
Eczema 35.12 27.32 36 12552 13790 29548149
Panic reaction 34.89 27.32 15 12573 1300 29560639
Eye swelling 34.54 27.32 29 12559 8628 29553311
Eye pruritus 34.40 27.32 22 12566 4310 29557629
Ocular discomfort 34.37 27.32 16 12572 1673 29560266
Anaemia 33.82 27.32 22 12566 200929 29361010
Platelet count decreased 33.53 27.32 3 12585 104669 29457270
Neutropenia 32.58 27.32 8 12580 131703 29430236
Peak expiratory flow rate decreased 32.10 27.32 8 12580 118 29561821
Gingival disorder 31.73 27.32 14 12574 1292 29560647
Arteriosclerosis coronary artery 31.36 27.32 30 12558 10575 29551364
Body temperature decreased 31.22 27.32 30 12558 10634 29551305
Sneezing 29.19 27.32 20 12568 4394 29557545
Diaphragmatic disorder 28.71 27.32 12 12576 970 29560969
Pneumonitis 28.04 27.32 46 12542 27998 29533941
Eosinophilic granulomatosis with polyangiitis 27.80 27.32 13 12575 1373 29560566
Rhinitis 27.76 27.32 20 12568 4758 29557181
Restrictive pulmonary disease 27.44 27.32 12 12576 1084 29560855

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 3231.33 18.87 1389 34363 93836 64369144
Wheezing 1755.60 18.87 866 34886 79713 64383267
Obstructive airways disorder 1310.11 18.87 490 35262 22695 64440285
Full blood count abnormal 789.78 18.87 367 35385 29390 64433590
Therapeutic product effect incomplete 776.92 18.87 560 35192 102922 64360058
Cough 620.96 18.87 798 34954 301350 64161630
Productive cough 620.66 18.87 427 35325 72776 64390204
Sputum discoloured 580.97 18.87 254 35498 17602 64445378
Sleep disorder due to a general medical condition 576.30 18.87 204 35548 8030 64454950
Dyspnoea 491.91 18.87 1165 34587 717509 63745471
Forced expiratory volume decreased 483.85 18.87 171 35581 6696 64456284
Chest discomfort 382.13 18.87 392 35360 115714 64347266
Breath sounds abnormal 312.66 18.87 145 35607 11524 64451456
Pulmonary function test decreased 284.24 18.87 114 35638 6347 64456633
Loss of personal independence in daily activities 281.57 18.87 268 35484 72186 64390794
Nasal congestion 281.36 18.87 246 35506 59412 64403568
Bronchiectasis 271.66 18.87 140 35612 14000 64448980
Asthma-chronic obstructive pulmonary disease overlap syndrome 237.71 18.87 65 35687 1060 64461920
Middle insomnia 237.33 18.87 124 35628 12753 64450227
Pneumonia viral 190.44 18.87 91 35661 7731 64455249
Acute kidney injury 176.81 18.87 21 35731 449219 64013761
Influenza 170.33 18.87 250 35502 106281 64356699
Dyspnoea exertional 165.22 18.87 204 35548 73526 64389454
Nasopharyngitis 164.14 18.87 346 35406 195727 64267253
Toxicity to various agents 161.98 18.87 10 35742 363503 64099477
Bronchial wall thickening 151.67 18.87 52 35700 1855 64461125
Respiratory disorder 146.72 18.87 137 35615 35974 64427006
Nasal obstruction 143.93 18.87 46 35706 1313 64461667
Nasal polyps 142.40 18.87 59 35693 3570 64459410
Upper-airway cough syndrome 137.89 18.87 76 35676 8694 64454286
Blood test abnormal 132.39 18.87 85 35667 12858 64450122
Glaucoma 128.07 18.87 91 35661 16257 64446723
Rhinitis 123.42 18.87 76 35676 10689 64452291
Blood immunoglobulin E increased 122.72 18.87 54 35698 3790 64459190
Sinus pain 121.94 18.87 48 35704 2541 64460439
Respiratory tract congestion 119.81 18.87 87 35665 16078 64446902
Drug interaction 116.02 18.87 29 35723 362054 64100926
Death 115.50 18.87 62 35690 482643 63980337
Soft tissue disorder 111.03 18.87 48 35704 3228 64459752
Bronchitis 110.21 18.87 208 35544 108535 64354445
Seasonal allergy 107.71 18.87 72 35680 11654 64451326
Gastrooesophageal reflux disease 106.16 18.87 176 35576 82967 64380013
Eosinophil count abnormal 105.81 18.87 30 35722 562 64462418
Restrictive pulmonary disease 104.87 18.87 41 35711 2131 64460849
Bronchial hyperreactivity 102.49 18.87 42 35710 2470 64460510
Arthritis 102.45 18.87 174 35578 83640 64379340
Heart rate increased 101.55 18.87 190 35562 98485 64364495
Diarrhoea 101.20 18.87 153 35599 722551 63740429
Sleep apnoea syndrome 98.40 18.87 101 35651 29731 64433249
Eosinophil count increased 97.93 18.87 73 35679 14039 64448941
Nasal turbinate hypertrophy 93.19 18.87 27 35725 548 64462432
Thrombocytopenia 91.63 18.87 9 35743 223792 64239188
Respiratory rate increased 91.20 18.87 78 35674 18253 64444727
Crepitations 91.04 18.87 56 35696 7859 64455121
Bronchial neoplasm 90.83 18.87 25 35727 418 64462562
Neutropenia 87.52 18.87 14 35738 239610 64223370
Pulmonary function test abnormal 86.86 18.87 40 35712 3124 64459856
Lower respiratory tract infection 86.13 18.87 173 35579 94441 64368539
Sinusitis 85.34 18.87 224 35528 145704 64317276
Dust allergy 84.86 18.87 29 35723 1024 64461956
Spirometry abnormal 84.34 18.87 25 35727 551 64462429
Body temperature decreased 84.10 18.87 87 35665 25841 64437139
Chronic obstructive pulmonary disease 82.23 18.87 144 35608 70904 64392076
Sensitivity to weather change 81.06 18.87 49 35703 6665 64456315
Hyper IgE syndrome 79.14 18.87 23 35729 472 64462508
Congenital hiatus hernia 78.21 18.87 22 35730 400 64462580
Hypoventilation 78.15 18.87 46 35706 5960 64457020
Rhonchi 77.39 18.87 38 35714 3425 64459555
Sputum purulent 76.81 18.87 28 35724 1198 64461782
Endometrial ablation 76.22 18.87 25 35727 776 64462204
Emphysema 74.38 18.87 62 35690 14007 64448973
Blood pressure systolic increased 73.15 18.87 112 35640 49341 64413639
Confusional state 72.61 18.87 27 35725 261117 64201863
Secretion discharge 72.29 18.87 57 35695 11907 64451073
Idiopathic intracranial hypertension 71.86 18.87 33 35719 2560 64460420
Bronchial disorder 71.71 18.87 31 35721 2084 64460896
Platelet count decreased 70.63 18.87 6 35746 167705 64295275
Bronchial haemorrhage 69.53 18.87 26 35726 1196 64461784
Herpes zoster 68.74 18.87 142 35610 79045 64383935
Kyphosis 68.04 18.87 31 35721 2362 64460618
Lung diffusion test abnormal 67.12 18.87 16 35736 145 64462835
Bronchial secretion retention 66.42 18.87 31 35721 2496 64460484
Conjunctivitis allergic 66.30 18.87 24 35728 1006 64461974
Pulmonary mass 66.30 18.87 74 35678 23942 64439038
Airway remodelling 65.70 18.87 16 35736 160 64462820
Rhinitis allergic 65.66 18.87 46 35706 8032 64454948
Peak expiratory flow rate decreased 65.45 18.87 21 35731 607 64462373
Rhinorrhoea 64.84 18.87 118 35634 59851 64403129
Mycobacterium avium complex infection 64.30 18.87 35 35717 3905 64459075
Hypotension 64.16 18.87 70 35682 380904 64082076
White blood cell count decreased 62.90 18.87 7 35745 157830 64305150
Broncholithiasis 62.72 18.87 15 35737 138 64462842
Blood pressure increased 61.65 18.87 223 35529 172329 64290651
Infusion related reaction 61.42 18.87 9 35743 164458 64298522
Ventricular failure 61.13 18.87 19 35733 494 64462486
Eosinophilic granulomatosis with polyangiitis 59.59 18.87 30 35722 2852 64460128
Mite allergy 58.61 18.87 20 35732 703 64462277
Pneumonia 57.92 18.87 517 35235 559059 63903921
Vomiting 57.42 18.87 139 35613 550978 63912002
Eosinophilia 57.39 18.87 87 35665 37989 64424991
Eosinophil count 55.87 18.87 13 35739 105 64462875
Lung consolidation 55.77 18.87 41 35711 7717 64455263
Allergy to animal 55.46 18.87 21 35731 1000 64461980
Eczema 55.20 18.87 75 35677 29645 64433335
Total lung capacity increased 55.11 18.87 19 35733 689 64462291
Drug abuse 55.01 18.87 5 35747 132369 64330611
Gastrointestinal haemorrhage 54.98 18.87 5 35747 132307 64330673
Overdose 54.60 18.87 11 35741 159555 64303425
Oropharyngeal pain 54.57 18.87 139 35613 88728 64374252
Malaise 54.55 18.87 391 35361 395856 64067124
Dehydration 54.48 18.87 26 35726 216737 64246243
Sepsis 54.36 18.87 30 35722 230311 64232669
Nausea 53.07 18.87 240 35512 785560 63677420
Nicotine dependence 52.52 18.87 19 35733 795 64462185
Mycotic allergy 52.31 18.87 20 35732 978 64462002
Lymph node calcification 51.79 18.87 15 35737 304 64462676
Vocal cord dysfunction 51.73 18.87 16 35736 409 64462571
Fibromyalgia 51.54 18.87 80 35672 35651 64427329
Haemoglobin decreased 51.20 18.87 22 35730 195041 64267939
Rales 51.01 18.87 52 35700 15177 64447803
Pancytopenia 50.91 18.87 9 35743 143300 64319680
Neuropathy peripheral 50.04 18.87 4 35748 117521 64345459
Throat clearing 49.96 18.87 21 35731 1317 64461663
Eosinophilic pneumonia chronic 49.80 18.87 15 35737 350 64462630
Febrile neutropenia 49.52 18.87 21 35731 187636 64275344
Respiratory symptom 49.49 18.87 27 35725 3026 64459954
Bacterial disease carrier 48.73 18.87 19 35733 980 64462000
Aspartate aminotransferase increased 48.52 18.87 5 35747 119783 64343197
Increased bronchial secretion 48.48 18.87 26 35726 2816 64460164
Disease progression 47.99 18.87 10 35742 141670 64321310
Weight decreased 47.75 18.87 296 35456 285443 64177537
Rash 47.45 18.87 116 35636 458433 64004547
Blood creatinine increased 47.21 18.87 9 35743 135773 64327207
Chronic sinusitis 46.92 18.87 34 35718 6258 64456722
Viral infection 46.75 18.87 77 35675 36063 64426917
Hypersensitivity 46.64 18.87 224 35528 196228 64266752
Illness 46.37 18.87 59 35693 21879 64441101
Polycystic ovaries 46.23 18.87 23 35729 2132 64460848
Dysphonia 46.05 18.87 88 35664 46294 64416686
Malignant neoplasm progression 44.98 18.87 5 35747 112866 64350114
Hypokalaemia 44.75 18.87 7 35745 121896 64341084
Alanine aminotransferase increased 44.71 18.87 11 35741 139020 64323960
Cardiac arrest 44.38 18.87 15 35737 154049 64308931
Vital capacity decreased 43.99 18.87 18 35734 1054 64461926
Neurosensory hypoacusis 42.98 18.87 12 35740 212 64462768
Off label use 42.81 18.87 193 35559 632613 63830367
Throat irritation 42.73 18.87 70 35682 32641 64430339
Nasal mucosal disorder 42.23 18.87 13 35739 327 64462653
Bronchospasm 42.22 18.87 56 35696 21626 64441354
Humidity intolerance 42.04 18.87 13 35739 332 64462648
Lower respiratory tract congestion 42.03 18.87 24 35728 2937 64460043
Seizure 41.95 18.87 20 35732 166872 64296108
Bronchial obstruction 41.29 18.87 22 35730 2352 64460628
Forced vital capacity decreased 41.10 18.87 19 35733 1497 64461483
Hyponatraemia 40.10 18.87 16 35736 148323 64314657
Reversible airways obstruction 39.63 18.87 17 35735 1121 64461859
Blood cholesterol increased 39.07 18.87 86 35666 49980 64413000
Decreased activity 38.69 18.87 32 35720 7148 64455832
Respiratory tract inflammation 38.45 18.87 15 35737 775 64462205
Infective exacerbation of chronic obstructive airways disease 37.97 18.87 21 35731 2417 64460563
Renal impairment 37.42 18.87 14 35738 135003 64327977
Asthenia 37.04 18.87 118 35634 427926 64035054
Eye pruritus 36.65 18.87 40 35712 12619 64450361
Sinus operation 36.09 18.87 18 35734 1677 64461303
Osteoporosis 35.96 18.87 75 35677 42005 64420975
Respiratory tract infection 35.94 18.87 70 35682 37337 64425643
Sneezing 35.41 18.87 43 35709 15208 64447772
Sinus congestion 34.99 18.87 43 35709 15396 64447584
Venous pressure jugular increased 34.77 18.87 16 35736 1247 64461733
Rib deformity 34.66 18.87 9 35743 119 64462861
Frustration tolerance decreased 34.48 18.87 28 35724 6097 64456883
Arthropathy 34.45 18.87 12 35740 120955 64342025
Limb injury 34.42 18.87 53 35699 23452 64439528
Oesophageal carcinoma 33.94 18.87 25 35727 4718 64458262
Infection 33.70 18.87 196 35556 184684 64278296
Rectal prolapse 32.88 18.87 17 35735 1709 64461271
Eosinophilic bronchitis 32.87 18.87 11 35741 364 64462616
Septic shock 32.64 18.87 9 35743 105428 64357552
Sputum increased 32.61 18.87 22 35730 3613 64459367
Inspiratory capacity abnormal 32.58 18.87 8 35744 83 64462897
Treatment failure 32.56 18.87 12 35740 116804 64346176
Oral pain 32.15 18.87 56 35696 27437 64435543
Weight increased 31.91 18.87 215 35537 213133 64249847
Therapeutic product effect decreased 31.90 18.87 12 35740 115339 64347641
Bradycardia 31.54 18.87 13 35739 118206 64344774
Depressed level of consciousness 31.47 18.87 4 35748 81432 64381548
Suffocation feeling 31.42 18.87 16 35736 1558 64461422
Oropharyngeal discomfort 31.33 18.87 25 35727 5310 64457670
Nocturnal dyspnoea 30.81 18.87 15 35737 1327 64461653
Oral candidiasis 30.76 18.87 50 35702 23162 64439818
Deep vein thrombosis 30.71 18.87 10 35742 105172 64357808
Secondary immunodeficiency 30.63 18.87 19 35733 2705 64460275
Oesophageal polyp 30.60 18.87 7 35745 52 64462928
Hepatic enzyme increased 30.53 18.87 17 35735 129926 64333054
Granuloma 30.49 18.87 27 35725 6614 64456366
Pneumonitis 30.09 18.87 78 35674 50287 64412693
Intentional product use issue 29.78 18.87 8 35744 95356 64367624
Pulmonary congestion 29.71 18.87 50 35702 23830 64439150
Respiration abnormal 29.64 18.87 26 35726 6289 64456691
Neutrophil count decreased 29.33 18.87 4 35748 77192 64385788
Hyperkalaemia 28.85 18.87 10 35742 101119 64361861
Renal failure 28.78 18.87 35 35717 181653 64281327
Affective disorder 28.72 18.87 26 35726 6554 64456426
Constipation 28.72 18.87 52 35700 229285 64233695
Urinary tract infection 28.57 18.87 53 35699 231543 64231437
Eye disorder 28.26 18.87 43 35709 18826 64444154
CFTR gene mutation 28.22 18.87 7 35745 76 64462904
Lipohypertrophy 28.14 18.87 12 35740 780 64462200
Peak expiratory flow rate abnormal 28.06 18.87 7 35745 78 64462902
Croup infectious 28.05 18.87 11 35741 576 64462404
Anaemia 27.69 18.87 112 35640 378568 64084412
Lung disorder 27.46 18.87 85 35667 60615 64402365
Cardiac failure 27.42 18.87 20 35732 132353 64330627
Multiple organ dysfunction syndrome 27.30 18.87 11 35741 101402 64361578
Total lung capacity decreased 27.28 18.87 15 35737 1707 64461273
Breast neoplasm 27.24 18.87 12 35740 844 64462136
Exposure to allergen 26.46 18.87 8 35744 189 64462791
Sarcoidosis 26.27 18.87 24 35728 6122 64456858
Ligament pain 26.23 18.87 8 35744 195 64462785
Coma 26.16 18.87 8 35744 87607 64375373
International normalised ratio increased 25.96 18.87 6 35746 79161 64383819
Rheumatoid arthritis 25.65 18.87 32 35720 164262 64298718
Ankle fracture 25.63 18.87 36 35716 14674 64448306
Contraindicated product administered 25.48 18.87 14 35738 107815 64355165
Hand deformity 24.46 18.87 3 35749 62768 64400212
Granulomatosis with polyangiitis 24.38 18.87 15 35737 2105 64460875
Asthmatic crisis 24.30 18.87 14 35738 1742 64461238
Diaphragmatic disorder 24.18 18.87 13 35739 1415 64461565
Ocular discomfort 24.04 18.87 19 35733 3980 64459000
Decreased appetite 23.98 18.87 78 35674 281211 64181769
Stress 23.97 18.87 81 35671 60453 64402527
Allergic sinusitis 23.00 18.87 9 35743 469 64462511
Oesophagogastroduodenoscopy 22.78 18.87 7 35745 175 64462805
Intentional product misuse 22.70 18.87 6 35746 72289 64390691
Osteopenia 22.69 18.87 35 35717 15505 64447475
Central nervous system mass 22.34 18.87 6 35746 91 64462889
Wall motion score index abnormal 21.99 18.87 6 35746 97 64462883
Sinus disorder 21.83 18.87 36 35716 16872 64446108
Ascites 21.78 18.87 4 35748 61997 64400983
Increased upper airway secretion 21.73 18.87 17 35735 3510 64459470
Rhabdomyolysis 21.54 18.87 12 35740 91714 64371266
Soft tissue swelling 21.41 18.87 11 35741 1091 64461889
Hypohidrosis 21.05 18.87 7 35745 227 64462753
Loss of consciousness 21.03 18.87 31 35721 148334 64314646
Lung opacity 20.97 18.87 16 35736 3183 64459797
Hepatic function abnormal 20.84 18.87 5 35747 64308 64398672
Hepatic failure 20.74 18.87 3 35749 55391 64407589
Type 2 diabetes mellitus 20.64 18.87 53 35699 33967 64429013
Pleural effusion 20.44 18.87 24 35728 126535 64336445
FEV1/FVC ratio decreased 20.43 18.87 6 35746 128 64462852
Atopy 20.22 18.87 7 35745 257 64462723
Symptom recurrence 20.18 18.87 10 35742 919 64462061
Agitation 20.12 18.87 12 35740 88355 64374625
Blister 19.88 18.87 10 35742 80957 64382023
Angioplasty 19.57 18.87 12 35740 1673 64461307
Occupational exposure to dust 19.57 18.87 4 35748 16 64462964
Respiratory arrest 19.54 18.87 3 35749 52982 64409998
Nasal oedema 19.41 18.87 10 35742 998 64461982
General physical health deterioration 19.34 18.87 54 35698 204371 64258609
Tenderness 19.21 18.87 37 35715 19565 64443415
Glossodynia 19.15 18.87 6 35746 64690 64398290
Nasal discharge discolouration 19.13 18.87 12 35740 1742 64461238
Blood alkaline phosphatase increased 18.99 18.87 4 35748 56275 64406705
Psoriasis 18.94 18.87 8 35744 71695 64391285

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R01AD13 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC R03BA08 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
Glucocorticoids
MeSH PA D018926 Anti-Allergic Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Allergic rhinitis indication 61582004
Asthma indication 195967001 DOID:2841
Seasonal allergic rhinitis indication 367498001
Asthma management indication 406162001
Severe chronic obstructive pulmonary disease off-label use 313299006
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Inactive tuberculosis contraindication 11999007
Epistaxis contraindication 12441001
Disease caused by parasite contraindication 17322007
Glaucoma contraindication 23986001 DOID:1686
Acute tuberculosis contraindication 25629007
Osteoporosis contraindication 64859006 DOID:11476
Operation on nose contraindication 88733004
Bilateral cataracts contraindication 95722004
Ophthalmic herpes simplex contraindication 186542001
Osteopenia contraindication 312894000
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Nasal Candidiasis contraindication
Oropharyngeal Candidiasis contraindication
Nasal Trauma contraindication
Uncontrolled Bacterial Infections contraindication
Nasal Septal Ulcers contraindication




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Horses Asthma indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Aservo EquiHaler Boehringer lngelheim Animal Health USA Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.78 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.08MG/INH ALVESCO COVIS N021658 Jan. 10, 2008 RX AEROSOL, METERED INHALATION 8371292 Feb. 1, 2028 MAINTENANCE TREATMENT OF ASTHMA AS PROPHYLACTIC THERAPY IN ADULT AND ADOLESCENT PATIENTS 12 YEARS OF AGE AND OLDER. PATENT CLAIMS METHOD FOR TREATING A RESPIRATORY DISEASE IN A CHILD
0.16MG/INH ALVESCO COVIS N021658 Jan. 10, 2008 RX AEROSOL, METERED INHALATION 8371292 Feb. 1, 2028 MAINTENANCE TREATMENT OF ASTHMA AS PROPHYLACTIC THERAPY IN ADULT AND ADOLESCENT PATIENTS 12 YEARS OF AGE AND OLDER. PATENT CLAIMS METHOD FOR TREATING A RESPIRATORY DISEASE IN A CHILD
0.05MG/SPRAY OMNARIS COVIS N022004 Oct. 20, 2006 RX SPRAY, METERED NASAL 8371292 Feb. 1, 2028 TREATMENT OF NASAL SYMPTOMS ASSOCIATED WITH SEASONAL ALLERGIC RHINITIS IN ADULTS AND CHILDREN 6 YEARS OF AGE AND OLDER. TREATMENT OF NASAL SYMPTOMS ASSOCIATED W PERENNIAL ALLERGIC RHINITIS IN ADULTS AND ADOLESCENTS 12 YEARS OF AGE AND OLDER
0.037MG/INH ZETONNA COVIS N202129 Jan. 20, 2012 RX AEROSOL, METERED NASAL 8371292 Feb. 1, 2028 TREATMENT OF SYMPTOMS ASSOCIATED WITH SEASONAL AND PERENNIAL ALLERGIC RHINITIS IN ADULTS AND ADOLESCENTS 12 YEARS OF AGE AND OLDER. PATENT CLAIMS METHODS FOR TREATING A RESPIRATORY DISEASE IN A CHILD

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST Ki 7.43 WOMBAT-PK CHEMBL

External reference:

IDSource
4027427 VUID
N0000179737 NUI
D01703 KEGG_DRUG
274964 RXNORM
4027427 VANDF
C0907850 UMLSCUI
CHEBI:31397 CHEBI
CHEMBL2040682 ChEMBL_ID
DB01410 DRUGBANK_ID
C120481 MESH_SUPPLEMENTAL_RECORD_UI
7469 IUPHAR_LIGAND_ID
6546 INN_ID
S59502J185 UNII
6918155 PUBCHEM_CID
132906 MMSL
19358 MMSL
89965 MMSL
d05465 MMSL
008829 NDDF
416739001 SNOMEDCT_US
417420004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Alvesco HUMAN PRESCRIPTION DRUG LABEL 1 54868-5989 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 27 sections
Alvesco HUMAN PRESCRIPTION DRUG LABEL 1 54868-5990 AEROSOL, METERED 160 ug RESPIRATORY (INHALATION) NDA 27 sections
Omnaris HUMAN PRESCRIPTION DRUG LABEL 1 54868-6020 SPRAY 50 ug NASAL NDA 13 sections
Omnaris HUMAN PRESCRIPTION DRUG LABEL 1 70515-701 SPRAY 50 ug NASAL NDA 27 sections
Alvesco HUMAN PRESCRIPTION DRUG LABEL 1 70515-711 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 26 sections
Alvesco HUMAN PRESCRIPTION DRUG LABEL 1 70515-712 AEROSOL, METERED 160 ug RESPIRATORY (INHALATION) NDA 26 sections
Zetonna HUMAN PRESCRIPTION DRUG LABEL 1 70515-737 AEROSOL, METERED 37 ug NASAL NDA 26 sections