ciclesonide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids for topical use, acetal derivatives | 633 | 126544-47-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
nasal spray approved for seasonal and perennial allergic rhinitis
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.20 | mg | N |
| 0.16 | mg | Inhal.aerosol |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.00 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 0 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.00 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 1 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 2.90 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 33.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.01 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.04 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 20, 2006 | FDA | TAKEDA GMBH |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Asthma | 2636.93 | 18.19 | 1326 | 34350 | 126235 | 63327111 |
| Wheezing | 1666.62 | 18.19 | 888 | 34788 | 94707 | 63358639 |
| Obstructive airways disorder | 1172.77 | 18.19 | 440 | 35236 | 20259 | 63433087 |
| Sleep disorder due to a general medical condition | 857.15 | 18.19 | 304 | 35372 | 11884 | 63441462 |
| Therapeutic product effect incomplete | 655.17 | 18.19 | 550 | 35126 | 124506 | 63328840 |
| Dyspnoea | 615.82 | 18.19 | 1223 | 34453 | 660090 | 62793256 |
| Full blood count abnormal | 535 | 18.19 | 289 | 35387 | 31428 | 63421918 |
| Cough | 513.33 | 18.19 | 721 | 34955 | 292022 | 63161324 |
| Productive cough | 489.97 | 18.19 | 351 | 35325 | 62857 | 63390489 |
| Sputum discoloured | 435.11 | 18.19 | 203 | 35473 | 16144 | 63437202 |
| Forced expiratory volume decreased | 399.43 | 18.19 | 137 | 35539 | 4831 | 63448515 |
| Loss of personal independence in daily activities | 357.58 | 18.19 | 351 | 35325 | 96939 | 63356407 |
| Chest discomfort | 346.36 | 18.19 | 365 | 35311 | 109604 | 63343742 |
| Pneumonia viral | 289.88 | 18.19 | 123 | 35553 | 7799 | 63445547 |
| Middle insomnia | 284.68 | 18.19 | 140 | 35536 | 12503 | 63440843 |
| Soft tissue disorder | 207.29 | 18.19 | 82 | 35594 | 4340 | 63449006 |
| Nasal polyps | 198.73 | 18.19 | 87 | 35589 | 5952 | 63447394 |
| Rhinitis | 189.91 | 18.19 | 103 | 35573 | 11263 | 63442083 |
| Asthma-chronic obstructive pulmonary disease overlap syndrome | 182.02 | 18.19 | 61 | 35615 | 2000 | 63451346 |
| Bronchial wall thickening | 175.72 | 18.19 | 55 | 35621 | 1444 | 63451902 |
| Breath sounds abnormal | 168.35 | 18.19 | 94 | 35582 | 10879 | 63442467 |
| Bronchial secretion retention | 167.99 | 18.19 | 62 | 35614 | 2711 | 63450635 |
| Bacterial disease carrier | 165.12 | 18.19 | 51 | 35625 | 1280 | 63452066 |
| Total lung capacity increased | 163.72 | 18.19 | 58 | 35618 | 2252 | 63451094 |
| Bronchiectasis | 149.20 | 18.19 | 100 | 35576 | 16042 | 63437304 |
| Nasal congestion | 147.25 | 18.19 | 183 | 35493 | 65477 | 63387869 |
| Lung diffusion test abnormal | 142.08 | 18.19 | 34 | 35642 | 309 | 63453037 |
| Sleep apnoea syndrome | 137.56 | 18.19 | 121 | 35555 | 29012 | 63424334 |
| Blood immunoglobulin E increased | 134.97 | 18.19 | 58 | 35618 | 3791 | 63449555 |
| Sputum purulent | 127.91 | 18.19 | 40 | 35636 | 1047 | 63452299 |
| Herpes zoster | 127.57 | 18.19 | 192 | 35484 | 82270 | 63371076 |
| Restrictive pulmonary disease | 126.95 | 18.19 | 45 | 35631 | 1750 | 63451596 |
| Sarcoidosis | 123.04 | 18.19 | 66 | 35610 | 7056 | 63446290 |
| Rhinitis allergic | 121.42 | 18.19 | 78 | 35598 | 11649 | 63441697 |
| Dyspnoea exertional | 120.91 | 18.19 | 159 | 35517 | 60143 | 63393203 |
| Arthritis | 120.65 | 18.19 | 226 | 35450 | 115695 | 63337651 |
| Eosinophilia | 120.63 | 18.19 | 101 | 35575 | 22655 | 63430691 |
| Gastrooesophageal reflux disease | 115.55 | 18.19 | 199 | 35477 | 95440 | 63357906 |
| Off label use | 114.04 | 18.19 | 127 | 35549 | 674335 | 62779011 |
| Heart rate increased | 111.13 | 18.19 | 194 | 35482 | 94044 | 63359302 |
| Diarrhoea | 111.09 | 18.19 | 144 | 35532 | 715222 | 62738124 |
| Blood test abnormal | 110.04 | 18.19 | 82 | 35594 | 15547 | 63437799 |
| Chronic obstructive pulmonary disease | 108.60 | 18.19 | 154 | 35522 | 62532 | 63390814 |
| Bronchial neoplasm | 105.76 | 18.19 | 29 | 35647 | 471 | 63452875 |
| Bronchial haemorrhage | 105.40 | 18.19 | 30 | 35646 | 562 | 63452784 |
| Bronchial disorder | 105.33 | 18.19 | 36 | 35640 | 1254 | 63452092 |
| Toxicity to various agents | 102.86 | 18.19 | 10 | 35666 | 247240 | 63206106 |
| Nasal turbinate hypertrophy | 102.15 | 18.19 | 31 | 35645 | 732 | 63452614 |
| Death | 101.10 | 18.19 | 42 | 35634 | 374339 | 63079007 |
| Superinfection | 100.43 | 18.19 | 42 | 35634 | 2565 | 63450781 |
| Infusion related reaction | 99.37 | 18.19 | 11 | 35665 | 245510 | 63207836 |
| Hyper IgE syndrome | 96.03 | 18.19 | 27 | 35649 | 483 | 63452863 |
| Acute kidney injury | 94.47 | 18.19 | 17 | 35659 | 263398 | 63189948 |
| Illness | 93.18 | 18.19 | 126 | 35550 | 48933 | 63404413 |
| Bronchospasm | 92.21 | 18.19 | 77 | 35599 | 17203 | 63436143 |
| Oral pain | 90.53 | 18.19 | 95 | 35581 | 28299 | 63425047 |
| Nasopharyngitis | 90.47 | 18.19 | 331 | 35345 | 253926 | 63199420 |
| Crepitations | 89.52 | 18.19 | 56 | 35620 | 7984 | 63445362 |
| Endometrial ablation | 86.98 | 18.19 | 29 | 35647 | 935 | 63452411 |
| Arthropathy | 86.73 | 18.19 | 14 | 35662 | 234778 | 63218568 |
| Throat clearing | 86.62 | 18.19 | 37 | 35639 | 2382 | 63450964 |
| Idiopathic intracranial hypertension | 86.09 | 18.19 | 39 | 35637 | 2892 | 63450454 |
| Upper-airway cough syndrome | 85.10 | 18.19 | 62 | 35614 | 11356 | 63441990 |
| Respiratory tract congestion | 84.04 | 18.19 | 74 | 35602 | 17758 | 63435588 |
| Blood pressure increased | 83.95 | 18.19 | 240 | 35436 | 161822 | 63291524 |
| Drug interaction | 83.88 | 18.19 | 14 | 35662 | 229117 | 63224229 |
| Pulmonary function test decreased | 83.77 | 18.19 | 42 | 35634 | 3905 | 63449441 |
| Secretion discharge | 83.50 | 18.19 | 63 | 35613 | 12168 | 63441178 |
| Influenza | 80.17 | 18.19 | 184 | 35492 | 108538 | 63344808 |
| Rash | 78.86 | 18.19 | 121 | 35555 | 560750 | 62892596 |
| Glaucoma | 78.38 | 18.19 | 73 | 35603 | 18832 | 63434514 |
| Sinus operation | 77.83 | 18.19 | 35 | 35641 | 2551 | 63450795 |
| Contraindicated product administered | 75.99 | 18.19 | 15 | 35661 | 217633 | 63235713 |
| Pneumonia | 75.97 | 18.19 | 477 | 35199 | 456290 | 62997056 |
| Factor V Leiden mutation | 75.87 | 18.19 | 19 | 35657 | 212 | 63453134 |
| Glossodynia | 74.99 | 18.19 | 7 | 35669 | 178869 | 63274477 |
| Asthma exercise induced | 74.54 | 18.19 | 20 | 35656 | 298 | 63453048 |
| Broncholithiasis | 74.16 | 18.19 | 19 | 35657 | 234 | 63453112 |
| Hand deformity | 73.27 | 18.19 | 4 | 35672 | 159453 | 63293893 |
| Confusional state | 73.27 | 18.19 | 21 | 35655 | 236359 | 63216987 |
| Treatment failure | 73.20 | 18.19 | 12 | 35664 | 199031 | 63254315 |
| Rib deformity | 72.31 | 18.19 | 19 | 35657 | 260 | 63453086 |
| Cardiac murmur | 71.82 | 18.19 | 62 | 35614 | 14490 | 63438856 |
| Ventricular failure | 70.81 | 18.19 | 20 | 35656 | 364 | 63452982 |
| Nicotine dependence | 70.44 | 18.19 | 23 | 35653 | 694 | 63452652 |
| Lymph node calcification | 69.04 | 18.19 | 19 | 35657 | 313 | 63453033 |
| Kyphosis | 68.96 | 18.19 | 32 | 35644 | 2508 | 63450838 |
| Thrombocytopenia | 68.81 | 18.19 | 4 | 35672 | 151153 | 63302193 |
| Reversible airways obstruction | 68.70 | 18.19 | 29 | 35647 | 1813 | 63451533 |
| Rhonchi | 68.53 | 18.19 | 32 | 35644 | 2544 | 63450802 |
| Neutropenia | 67.93 | 18.19 | 9 | 35667 | 174996 | 63278350 |
| Nasal obstruction | 67.06 | 18.19 | 28 | 35648 | 1703 | 63451643 |
| Dysphonia | 66.77 | 18.19 | 106 | 35570 | 47508 | 63405838 |
| Body temperature decreased | 64.80 | 18.19 | 68 | 35608 | 20251 | 63433095 |
| Respiratory disorder | 64.71 | 18.19 | 94 | 35582 | 38988 | 63414358 |
| Therapeutic product effect decreased | 63.99 | 18.19 | 15 | 35661 | 193172 | 63260174 |
| Eosinophil count increased | 63.13 | 18.19 | 51 | 35625 | 10877 | 63442469 |
| Bronchitis | 61.75 | 18.19 | 182 | 35494 | 124753 | 63328593 |
| Allergy to animal | 61.54 | 18.19 | 24 | 35652 | 1222 | 63452124 |
| Pericarditis | 61.39 | 18.19 | 3 | 35673 | 131576 | 63321770 |
| Forced vital capacity decreased | 61.24 | 18.19 | 23 | 35653 | 1056 | 63452290 |
| Alopecia | 59.70 | 18.19 | 61 | 35615 | 337475 | 63115871 |
| Cryopyrin associated periodic syndrome | 58.54 | 18.19 | 17 | 35659 | 343 | 63453003 |
| Nausea | 58.30 | 18.19 | 265 | 35411 | 854206 | 62599140 |
| Hypoventilation | 57.73 | 18.19 | 35 | 35641 | 4719 | 63448627 |
| Secondary immunodeficiency | 55.70 | 18.19 | 23 | 35653 | 1360 | 63451986 |
| Hypomania | 55.58 | 18.19 | 38 | 35638 | 6292 | 63447054 |
| Pulmonary mass | 55.52 | 18.19 | 66 | 35610 | 22530 | 63430816 |
| Mycobacterium avium complex infection | 54.41 | 18.19 | 29 | 35647 | 3059 | 63450287 |
| White blood cell count decreased | 54.35 | 18.19 | 7 | 35669 | 139097 | 63314249 |
| Liver function test abnormal | 53.93 | 18.19 | 97 | 35579 | 48084 | 63405262 |
| Increased bronchial secretion | 53.46 | 18.19 | 24 | 35652 | 1742 | 63451604 |
| Oropharyngeal pain | 51.89 | 18.19 | 143 | 35533 | 94344 | 63359002 |
| Hypotension | 50.81 | 18.19 | 47 | 35629 | 272557 | 63180789 |
| Rheumatoid arthritis | 50.66 | 18.19 | 41 | 35635 | 253778 | 63199568 |
| Jaundice cholestatic | 50.60 | 18.19 | 38 | 35638 | 7286 | 63446060 |
| Respiratory rate increased | 49.57 | 18.19 | 49 | 35627 | 13599 | 63439747 |
| Fibromyalgia | 49.52 | 18.19 | 127 | 35549 | 80293 | 63373053 |
| Lung neoplasm malignant | 49.32 | 18.19 | 58 | 35618 | 19575 | 63433771 |
| Urinary tract infection | 48.90 | 18.19 | 46 | 35630 | 264638 | 63188708 |
| Oropharyngeal discomfort | 47.19 | 18.19 | 32 | 35644 | 5228 | 63448118 |
| Neurosensory hypoacusis | 47.08 | 18.19 | 13 | 35663 | 217 | 63453129 |
| Rales | 46.88 | 18.19 | 46 | 35630 | 12651 | 63440695 |
| Venous pressure jugular increased | 46.71 | 18.19 | 16 | 35660 | 561 | 63452785 |
| Hypokalaemia | 46.47 | 18.19 | 3 | 35673 | 103801 | 63349545 |
| Intentional product use issue | 46.36 | 18.19 | 8 | 35668 | 127884 | 63325462 |
| Abdominal discomfort | 46.18 | 18.19 | 68 | 35608 | 320817 | 63132529 |
| Scoliosis | 45.96 | 18.19 | 37 | 35639 | 7851 | 63445495 |
| Nasal mucosal disorder | 45.89 | 18.19 | 15 | 35661 | 454 | 63452892 |
| Sinusitis | 45.51 | 18.19 | 249 | 35427 | 226404 | 63226942 |
| Viral infection | 45.39 | 18.19 | 76 | 35600 | 35587 | 63417759 |
| Blister | 45.17 | 18.19 | 9 | 35667 | 129805 | 63323541 |
| Blood pressure systolic increased | 45.06 | 18.19 | 89 | 35587 | 47308 | 63406038 |
| Platelet count decreased | 44.98 | 18.19 | 6 | 35670 | 116116 | 63337230 |
| Polycystic ovaries | 44.46 | 18.19 | 29 | 35647 | 4442 | 63448904 |
| Psychotic disorder | 44.25 | 18.19 | 63 | 35613 | 25649 | 63427697 |
| Disease progression | 43.80 | 18.19 | 8 | 35668 | 122750 | 63330596 |
| Vocal cord dysfunction | 43.36 | 18.19 | 15 | 35661 | 542 | 63452804 |
| Impaired healing | 42.99 | 18.19 | 4 | 35672 | 102538 | 63350808 |
| Schizophrenia | 42.35 | 18.19 | 39 | 35637 | 9913 | 63443433 |
| Granuloma | 42.29 | 18.19 | 31 | 35645 | 5730 | 63447616 |
| Respiratory tract inflammation | 42.17 | 18.19 | 15 | 35661 | 589 | 63452757 |
| Nonspecific reaction | 41.73 | 18.19 | 22 | 35654 | 2270 | 63451076 |
| Peak expiratory flow rate decreased | 41.58 | 18.19 | 15 | 35661 | 614 | 63452732 |
| Eczema | 41.35 | 18.19 | 69 | 35607 | 32222 | 63421124 |
| Dehydration | 41.29 | 18.19 | 23 | 35653 | 173331 | 63280015 |
| Humidity intolerance | 41.25 | 18.19 | 13 | 35663 | 349 | 63452997 |
| Affective disorder | 40.50 | 18.19 | 31 | 35645 | 6115 | 63447231 |
| Sensitivity to weather change | 40.17 | 18.19 | 33 | 35643 | 7204 | 63446142 |
| Blood cholesterol increased | 39.96 | 18.19 | 130 | 35546 | 93902 | 63359444 |
| Eosinophilic pneumonia chronic | 39.64 | 18.19 | 11 | 35665 | 187 | 63453159 |
| CFTR gene mutation | 39.58 | 18.19 | 10 | 35666 | 116 | 63453230 |
| Muscle tension dysphonia | 38.80 | 18.19 | 11 | 35665 | 203 | 63453143 |
| Airway remodelling | 38.41 | 18.19 | 9 | 35667 | 74 | 63453272 |
| Febrile neutropenia | 37.65 | 18.19 | 10 | 35666 | 118439 | 63334907 |
| Pancytopenia | 37.56 | 18.19 | 5 | 35671 | 96928 | 63356418 |
| Atelectasis | 37.51 | 18.19 | 53 | 35623 | 21430 | 63431916 |
| Limb injury | 37.49 | 18.19 | 58 | 35618 | 25419 | 63427927 |
| Malaise | 37.25 | 18.19 | 377 | 35299 | 415577 | 63037769 |
| Psoriatic arthropathy | 37.24 | 18.19 | 4 | 35672 | 91516 | 63361830 |
| Seizure | 37.17 | 18.19 | 14 | 35662 | 132620 | 63320726 |
| Skin lesion | 37.15 | 18.19 | 64 | 35612 | 30657 | 63422689 |
| Anti-cyclic citrullinated peptide antibody positive | 36.58 | 18.19 | 10 | 35666 | 116202 | 63337144 |
| Decreased appetite | 36.30 | 18.19 | 53 | 35623 | 250999 | 63202347 |
| Discomfort | 35.99 | 18.19 | 25 | 35651 | 167349 | 63285997 |
| Dyslipidaemia | 35.47 | 18.19 | 31 | 35645 | 7362 | 63445984 |
| Blood creatinine increased | 35.34 | 18.19 | 4 | 35672 | 87840 | 63365506 |
| Malignant neoplasm progression | 34.97 | 18.19 | 3 | 35673 | 82118 | 63371228 |
| Vomiting | 34.86 | 18.19 | 179 | 35497 | 559438 | 62893908 |
| FEV1/FVC ratio decreased | 34.82 | 18.19 | 9 | 35667 | 115 | 63453231 |
| Chest X-ray abnormal | 34.57 | 18.19 | 25 | 35651 | 4524 | 63448822 |
| Pulmonary function test abnormal | 34.56 | 18.19 | 18 | 35658 | 1812 | 63451534 |
| Gastrointestinal haemorrhage | 34.48 | 18.19 | 3 | 35673 | 81173 | 63372173 |
| Eosinophilic granulomatosis with polyangiitis | 34.22 | 18.19 | 19 | 35657 | 2173 | 63451173 |
| Respiratory tract infection | 33.68 | 18.19 | 73 | 35603 | 41410 | 63411936 |
| Lipohypertrophy | 33.52 | 18.19 | 13 | 35663 | 652 | 63452694 |
| Abscess | 33.46 | 18.19 | 44 | 35632 | 16624 | 63436722 |
| Sepsis | 32.75 | 18.19 | 23 | 35653 | 153100 | 63300246 |
| Breast neoplasm | 32.65 | 18.19 | 16 | 35660 | 1416 | 63451930 |
| Rib fracture | 32.63 | 18.19 | 51 | 35625 | 22546 | 63430800 |
| Haemoglobin decreased | 32.26 | 18.19 | 21 | 35655 | 145464 | 63307882 |
| Sinus disorder | 32.15 | 18.19 | 53 | 35623 | 24500 | 63428846 |
| Emphysema | 32.04 | 18.19 | 35 | 35641 | 10903 | 63442443 |
| Aspartate aminotransferase increased | 31.95 | 18.19 | 6 | 35670 | 90271 | 63363075 |
| Asthmatic crisis | 31.87 | 18.19 | 17 | 35659 | 1796 | 63451550 |
| Peak expiratory flow rate abnormal | 31.34 | 18.19 | 8 | 35668 | 97 | 63453249 |
| Hyponatraemia | 31.04 | 18.19 | 12 | 35664 | 111888 | 63341458 |
| Lung disorder | 31.02 | 18.19 | 91 | 35585 | 62170 | 63391176 |
| Granulomatosis with polyangiitis | 30.96 | 18.19 | 18 | 35658 | 2247 | 63451099 |
| Frustration tolerance decreased | 30.94 | 18.19 | 28 | 35648 | 6960 | 63446386 |
| Rectal prolapse | 30.44 | 18.19 | 17 | 35659 | 1966 | 63451380 |
| Neuropathy peripheral | 30.21 | 18.19 | 13 | 35663 | 113654 | 63339692 |
| Angioplasty | 30.09 | 18.19 | 15 | 35661 | 1377 | 63451969 |
| Hepatic enzyme increased | 29.94 | 18.19 | 42 | 35634 | 202286 | 63251060 |
| Crystal arthropathy | 29.89 | 18.19 | 10 | 35666 | 326 | 63453020 |
| Ankle fracture | 29.63 | 18.19 | 43 | 35633 | 17812 | 63435534 |
| Maternal exposure during pregnancy | 29.38 | 18.19 | 49 | 35627 | 220013 | 63233333 |
| Alanine aminotransferase increased | 29.00 | 18.19 | 11 | 35665 | 103759 | 63349587 |
| Renal impairment | 28.96 | 18.19 | 7 | 35669 | 88348 | 63364998 |
| Exposure during pregnancy | 28.74 | 18.19 | 27 | 35649 | 155520 | 63297826 |
| Croup infectious | 28.66 | 18.19 | 11 | 35665 | 536 | 63452810 |
| Leukopenia | 28.57 | 18.19 | 102 | 35574 | 77188 | 63376158 |
| Lower respiratory tract infection | 28.32 | 18.19 | 148 | 35528 | 132159 | 63321187 |
| Psoriasis | 28.29 | 18.19 | 7 | 35669 | 86950 | 63366396 |
| Pulmonary congestion | 27.53 | 18.19 | 41 | 35635 | 17377 | 63435969 |
| Constipation | 27.41 | 18.19 | 53 | 35623 | 224890 | 63228456 |
| Seasonal allergy | 27.13 | 18.19 | 45 | 35631 | 20905 | 63432441 |
| Respiration abnormal | 27.02 | 18.19 | 25 | 35651 | 6392 | 63446954 |
| Pain | 26.28 | 18.19 | 278 | 35398 | 740350 | 62712996 |
| Exposure to allergen | 26.13 | 18.19 | 9 | 35667 | 321 | 63453025 |
| Chronic sinusitis | 25.93 | 18.19 | 34 | 35642 | 12809 | 63440537 |
| Ligament pain | 25.52 | 18.19 | 8 | 35668 | 211 | 63453135 |
| Forced expiratory volume | 25.50 | 18.19 | 5 | 35671 | 15 | 63453331 |
| Weight decreased | 25.27 | 18.19 | 252 | 35424 | 276546 | 63176800 |
| Sinus congestion | 24.92 | 18.19 | 40 | 35636 | 18083 | 63435263 |
| Fear of disease | 24.84 | 18.19 | 13 | 35663 | 1321 | 63452025 |
| Tenderness | 24.68 | 18.19 | 45 | 35631 | 22533 | 63430813 |
| Eosinophil count abnormal | 24.43 | 18.19 | 10 | 35666 | 578 | 63452768 |
| Sinus pain | 24.24 | 18.19 | 18 | 35658 | 3392 | 63449954 |
| Lung diffusion disorder | 23.79 | 18.19 | 6 | 35670 | 69 | 63453277 |
| Rhinorrhoea | 23.77 | 18.19 | 86 | 35590 | 65491 | 63387855 |
| Stress | 23.43 | 18.19 | 87 | 35589 | 67080 | 63386266 |
| Drug abuse | 23.27 | 18.19 | 6 | 35670 | 72512 | 63380834 |
| Deep vein thrombosis | 23.22 | 18.19 | 9 | 35667 | 83791 | 63369555 |
| Nocturnal dyspnoea | 23 | 18.19 | 12 | 35664 | 1212 | 63452134 |
| Choking | 22.87 | 18.19 | 28 | 35648 | 9851 | 63443495 |
| Soft tissue swelling | 22.82 | 18.19 | 12 | 35664 | 1232 | 63452114 |
| Lung diffusion test decreased | 22.78 | 18.19 | 10 | 35666 | 688 | 63452658 |
| Swelling | 22.71 | 18.19 | 79 | 35597 | 275299 | 63178047 |
| Cholelithiasis | 22.64 | 18.19 | 65 | 35611 | 43860 | 63409486 |
| Impaired quality of life | 22.59 | 18.19 | 33 | 35643 | 13750 | 63439596 |
| Paranasal sinus inflammation | 22.57 | 18.19 | 9 | 35667 | 486 | 63452860 |
| Infection | 22.56 | 18.19 | 212 | 35464 | 228961 | 63224385 |
| Aphonia | 22.45 | 18.19 | 28 | 35648 | 10035 | 63443311 |
| Sinus tachycardia | 22.38 | 18.19 | 45 | 35631 | 24223 | 63429123 |
| Lower respiratory tract congestion | 22.25 | 18.19 | 16 | 35660 | 2870 | 63450476 |
| Depressed level of consciousness | 22.23 | 18.19 | 4 | 35672 | 62074 | 63391272 |
| Forearm fracture | 22.11 | 18.19 | 9 | 35667 | 513 | 63452833 |
| Musculoskeletal stiffness | 22.05 | 18.19 | 44 | 35632 | 184574 | 63268772 |
| Oedema | 21.76 | 18.19 | 14 | 35662 | 97608 | 63355738 |
| Intentional product misuse | 21.66 | 18.19 | 4 | 35672 | 60913 | 63392433 |
| Eosinophilic bronchitis | 21.30 | 18.19 | 9 | 35667 | 564 | 63452782 |
| Therapy non-responder | 21.28 | 18.19 | 8 | 35668 | 75893 | 63377453 |
| Allergic sinusitis | 21.08 | 18.19 | 11 | 35665 | 1111 | 63452235 |
| Adverse event | 20.91 | 18.19 | 6 | 35670 | 67553 | 63385793 |
| Fibromuscular dysplasia | 20.72 | 18.19 | 7 | 35669 | 235 | 63453111 |
| Osteoporosis | 20.61 | 18.19 | 75 | 35601 | 57263 | 63396083 |
| Pancreatitis relapsing | 20.25 | 18.19 | 10 | 35666 | 900 | 63452446 |
| Blood glucose increased | 20.09 | 18.19 | 11 | 35665 | 83745 | 63369601 |
| Lip pruritus | 19.87 | 18.19 | 10 | 35666 | 937 | 63452409 |
| Respiratory failure | 19.62 | 18.19 | 17 | 35659 | 101841 | 63351505 |
| Smoke sensitivity | 19.62 | 18.19 | 8 | 35668 | 458 | 63452888 |
| Lung hyperinflation | 19.60 | 18.19 | 11 | 35665 | 1284 | 63452062 |
| Multiple organ dysfunction syndrome | 19.60 | 18.19 | 4 | 35672 | 56748 | 63396598 |
| Pleural rub | 19.48 | 18.19 | 5 | 35671 | 62 | 63453284 |
| Cognitive disorder | 19.14 | 18.19 | 4 | 35672 | 55811 | 63397535 |
| Fluid retention | 19.03 | 18.19 | 5 | 35671 | 59681 | 63393665 |
| Overdose | 18.97 | 18.19 | 22 | 35654 | 115056 | 63338290 |
| Total lung capacity decreased | 18.92 | 18.19 | 13 | 35663 | 2170 | 63451176 |
| Oesophagogastroduodenoscopy | 18.90 | 18.19 | 6 | 35670 | 165 | 63453181 |
| Animal scratch | 18.67 | 18.19 | 11 | 35665 | 1407 | 63451939 |
| Laryngeal stenosis | 18.65 | 18.19 | 10 | 35666 | 1068 | 63452278 |
| Suicidal ideation | 18.49 | 18.19 | 6 | 35670 | 62415 | 63390931 |
| Myalgia | 18.33 | 18.19 | 143 | 35533 | 146386 | 63306960 |
| Blood immunoglobulin E decreased | 18.30 | 18.19 | 5 | 35671 | 80 | 63453266 |
| Forced expiratory volume abnormal | 18.25 | 18.19 | 5 | 35671 | 81 | 63453265 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Asthma | 1981.80 | 26.01 | 744 | 15668 | 41912 | 34898607 |
| Wheezing | 1140.42 | 26.01 | 497 | 15915 | 40905 | 34899614 |
| Therapeutic product effect incomplete | 806.78 | 26.01 | 417 | 15995 | 50124 | 34890395 |
| Obstructive airways disorder | 781.13 | 26.01 | 288 | 16124 | 15206 | 34925313 |
| Full blood count abnormal | 666.34 | 26.01 | 270 | 16142 | 18398 | 34922121 |
| Sleep disorder due to a general medical condition | 532.80 | 26.01 | 165 | 16247 | 5056 | 34935463 |
| Bronchiectasis | 420.28 | 26.01 | 162 | 16250 | 9639 | 34930880 |
| Loss of personal independence in daily activities | 366.13 | 26.01 | 215 | 16197 | 32964 | 34907555 |
| Productive cough | 350.24 | 26.01 | 219 | 16193 | 37594 | 34902925 |
| Pulmonary function test decreased | 304.89 | 26.01 | 107 | 16305 | 4868 | 34935651 |
| Sputum discoloured | 281.82 | 26.01 | 114 | 16298 | 7698 | 34932821 |
| Dyspnoea | 265.61 | 26.01 | 559 | 15853 | 376223 | 34564296 |
| Cough | 256.65 | 26.01 | 333 | 16079 | 149807 | 34790712 |
| Asthma-chronic obstructive pulmonary disease overlap syndrome | 253.93 | 26.01 | 68 | 16344 | 1219 | 34939300 |
| Breath sounds abnormal | 233.10 | 26.01 | 96 | 16316 | 6785 | 34933734 |
| Nasal congestion | 232.28 | 26.01 | 141 | 16271 | 22916 | 34917603 |
| Chest discomfort | 207.26 | 26.01 | 185 | 16227 | 54345 | 34886174 |
| Respiratory disorder | 186.81 | 26.01 | 115 | 16297 | 19149 | 34921370 |
| Nasal obstruction | 183.02 | 26.01 | 46 | 16366 | 634 | 34939885 |
| Forced expiratory volume decreased | 181.44 | 26.01 | 65 | 16347 | 3138 | 34937381 |
| Dust allergy | 174.63 | 26.01 | 47 | 16365 | 859 | 34939660 |
| Sinus pain | 170.20 | 26.01 | 44 | 16368 | 683 | 34939836 |
| Nasal polyps | 161.65 | 26.01 | 56 | 16356 | 2447 | 34938072 |
| Eosinophil count abnormal | 156.63 | 26.01 | 35 | 16377 | 279 | 34940240 |
| Bronchial hyperreactivity | 153.36 | 26.01 | 49 | 16363 | 1660 | 34938859 |
| Congenital hiatus hernia | 149.66 | 26.01 | 41 | 16371 | 803 | 34939716 |
| Mite allergy | 147.54 | 26.01 | 39 | 16373 | 663 | 34939856 |
| Spirometry abnormal | 141.62 | 26.01 | 38 | 16374 | 686 | 34939833 |
| Conjunctivitis allergic | 140.75 | 26.01 | 42 | 16370 | 1128 | 34939391 |
| Eosinophil count increased | 139.83 | 26.01 | 72 | 16340 | 8500 | 34932019 |
| Mycotic allergy | 138.46 | 26.01 | 36 | 16376 | 572 | 34939947 |
| Dyspnoea exertional | 119.12 | 26.01 | 123 | 16289 | 43156 | 34897363 |
| Mycobacterium avium complex infection | 116.50 | 26.01 | 44 | 16368 | 2467 | 34938052 |
| Blood immunoglobulin E increased | 108.74 | 26.01 | 42 | 16370 | 2504 | 34938015 |
| Adrenal suppression | 108.11 | 26.01 | 30 | 16382 | 617 | 34939902 |
| Acute kidney injury | 107.12 | 26.01 | 10 | 16402 | 304978 | 34635541 |
| Influenza | 101.85 | 26.01 | 121 | 16291 | 49545 | 34890974 |
| Seasonal allergy | 100.10 | 26.01 | 53 | 16359 | 6622 | 34933897 |
| Lung consolidation | 97.21 | 26.01 | 50 | 16362 | 5886 | 34934633 |
| Pulmonary function test abnormal | 93.77 | 26.01 | 38 | 16374 | 2572 | 34937947 |
| Eye disorder | 85.05 | 26.01 | 54 | 16358 | 9474 | 34931045 |
| Rhinorrhoea | 83.62 | 26.01 | 80 | 16332 | 25588 | 34914931 |
| Gingival disorder | 83.54 | 26.01 | 30 | 16382 | 1457 | 34939062 |
| Vital capacity decreased | 83.44 | 26.01 | 22 | 16390 | 370 | 34940149 |
| Osteopenia | 82.76 | 26.01 | 42 | 16370 | 4807 | 34935712 |
| Sinusitis | 80.17 | 26.01 | 98 | 16314 | 41304 | 34899215 |
| Emphysema | 80.12 | 26.01 | 52 | 16360 | 9473 | 34931046 |
| Throat irritation | 79.87 | 26.01 | 54 | 16358 | 10531 | 34929988 |
| Airway remodelling | 78.63 | 26.01 | 19 | 16393 | 220 | 34940299 |
| Lower respiratory tract infection | 78.28 | 26.01 | 85 | 16327 | 31552 | 34908967 |
| Chronic sinusitis | 77.84 | 26.01 | 32 | 16380 | 2247 | 34938272 |
| Malignant melanoma in situ | 75.55 | 26.01 | 29 | 16383 | 1699 | 34938820 |
| Hypoxia | 75.31 | 26.01 | 110 | 16302 | 54985 | 34885534 |
| Toxicity to various agents | 74.64 | 26.01 | 5 | 16407 | 200357 | 34740162 |
| Chronic obstructive pulmonary disease | 73.23 | 26.01 | 102 | 16310 | 48816 | 34891703 |
| Upper-airway cough syndrome | 73.18 | 26.01 | 35 | 16377 | 3523 | 34936996 |
| Pulmonary mass | 70.60 | 26.01 | 54 | 16358 | 12758 | 34927761 |
| Eosinophil count | 70.27 | 26.01 | 16 | 16396 | 140 | 34940379 |
| Vocal cord dysfunction | 67.81 | 26.01 | 16 | 16396 | 166 | 34940353 |
| Gastrooesophageal reflux disease | 67.39 | 26.01 | 86 | 16326 | 37838 | 34902681 |
| Death | 66.38 | 26.01 | 54 | 16358 | 397995 | 34542524 |
| Nodule | 64.25 | 26.01 | 40 | 16372 | 6779 | 34933740 |
| Eczema | 62.97 | 26.01 | 59 | 16353 | 18377 | 34922142 |
| Oral disorder | 58.83 | 26.01 | 32 | 16380 | 4217 | 34936302 |
| Skin irritation | 58.40 | 26.01 | 35 | 16377 | 5542 | 34934977 |
| Decreased activity | 57.87 | 26.01 | 32 | 16380 | 4355 | 34936164 |
| Suffocation feeling | 57.24 | 26.01 | 18 | 16394 | 578 | 34939941 |
| Drug interaction | 56.39 | 26.01 | 18 | 16394 | 225928 | 34714591 |
| Eosinophilic granulomatosis with polyangiitis | 54.89 | 26.01 | 24 | 16388 | 1963 | 34938556 |
| Normochromic normocytic anaemia | 53.09 | 26.01 | 30 | 16382 | 4257 | 34936262 |
| Thrombocytopenia | 52.47 | 26.01 | 6 | 16406 | 156241 | 34784278 |
| Middle insomnia | 52.02 | 26.01 | 35 | 16377 | 6767 | 34933752 |
| Pleural thickening | 51.47 | 26.01 | 15 | 16397 | 370 | 34940149 |
| Inspiratory capacity abnormal | 51.26 | 26.01 | 12 | 16400 | 120 | 34940399 |
| Diaphragmatic disorder | 50.79 | 26.01 | 20 | 16392 | 1255 | 34939264 |
| Arteriosclerosis coronary artery | 50.60 | 26.01 | 44 | 16368 | 12441 | 34928078 |
| Diarrhoea | 50.15 | 26.01 | 66 | 16346 | 389846 | 34550673 |
| Sensitivity to weather change | 49.38 | 26.01 | 21 | 16391 | 1605 | 34938914 |
| Atopy | 48.22 | 26.01 | 13 | 16399 | 239 | 34940280 |
| Neutropenia | 47.98 | 26.01 | 8 | 16404 | 156770 | 34783749 |
| Oesophageal polyp | 47.50 | 26.01 | 10 | 16402 | 58 | 34940461 |
| Respiratory symptom | 47.36 | 26.01 | 21 | 16391 | 1776 | 34938743 |
| Bronchial obstruction | 46.21 | 26.01 | 20 | 16392 | 1596 | 34938923 |
| Bronchitis | 45.06 | 26.01 | 75 | 16337 | 41888 | 34898631 |
| Sneezing | 45.02 | 26.01 | 29 | 16383 | 5213 | 34935306 |
| Sputum increased | 44.78 | 26.01 | 22 | 16390 | 2348 | 34938171 |
| Glaucoma | 44.51 | 26.01 | 32 | 16380 | 6880 | 34933639 |
| Platelet count decreased | 44.50 | 26.01 | 3 | 16409 | 119714 | 34820805 |
| Ocular discomfort | 43.91 | 26.01 | 21 | 16391 | 2113 | 34938406 |
| Anaemia | 43.56 | 26.01 | 28 | 16384 | 233307 | 34707212 |
| Respiratory tract congestion | 43.18 | 26.01 | 30 | 16382 | 6109 | 34934410 |
| Benign prostatic hyperplasia | 43.12 | 26.01 | 43 | 16369 | 14452 | 34926067 |
| Bronchial wall thickening | 42.65 | 26.01 | 18 | 16394 | 1350 | 34939169 |
| Pneumonitis | 42.48 | 26.01 | 65 | 16347 | 33813 | 34906706 |
| Eosinophilia | 41.20 | 26.01 | 56 | 16356 | 26166 | 34914353 |
| Asthenia | 41.11 | 26.01 | 33 | 16379 | 245218 | 34695301 |
| Nasopharyngitis | 41.01 | 26.01 | 97 | 16315 | 69871 | 34870648 |
| Adrenal insufficiency | 40.55 | 26.01 | 41 | 16371 | 14006 | 34926513 |
| Infective exacerbation of chronic obstructive airways disease | 40.49 | 26.01 | 19 | 16393 | 1832 | 34938687 |
| Rhinitis | 40.03 | 26.01 | 29 | 16383 | 6309 | 34934210 |
| Micturition urgency | 39.27 | 26.01 | 29 | 16383 | 6496 | 34934023 |
| Joint injury | 38.53 | 26.01 | 33 | 16379 | 9140 | 34931379 |
| Respiratory rate increased | 38.35 | 26.01 | 34 | 16378 | 9860 | 34930659 |
| Illness | 38.16 | 26.01 | 39 | 16373 | 13490 | 34927029 |
| Panic reaction | 38.11 | 26.01 | 17 | 16395 | 1458 | 34939061 |
| Restrictive pulmonary disease | 38.06 | 26.01 | 16 | 16396 | 1188 | 34939331 |
| Eye swelling | 36.08 | 26.01 | 33 | 16379 | 9962 | 34930557 |
| Peak expiratory flow rate decreased | 35.41 | 26.01 | 9 | 16403 | 130 | 34940389 |
| Kidney infection | 34.79 | 26.01 | 25 | 16387 | 5369 | 34935150 |
| Constipation | 33.97 | 26.01 | 11 | 16401 | 136971 | 34803548 |
| Vascular shunt | 33.64 | 26.01 | 7 | 16405 | 38 | 34940481 |
| Blood test abnormal | 33.27 | 26.01 | 27 | 16385 | 6944 | 34933575 |
| Central nervous system mass | 33.15 | 26.01 | 9 | 16403 | 170 | 34940349 |
| Wall motion score index abnormal | 33.00 | 26.01 | 9 | 16403 | 173 | 34940346 |
| Hypercholesterolaemia | 31.77 | 26.01 | 29 | 16383 | 8733 | 34931786 |
| Eye pruritus | 31.57 | 26.01 | 27 | 16385 | 7462 | 34933057 |
| Sepsis | 31.03 | 26.01 | 20 | 16392 | 166541 | 34773978 |
| Malignant neoplasm progression | 30.51 | 26.01 | 3 | 16409 | 88043 | 34852476 |
| Disease progression | 29.93 | 26.01 | 7 | 16405 | 108070 | 34832449 |
| Haemoglobin decreased | 29.42 | 26.01 | 10 | 16402 | 120762 | 34819757 |
| Stridor | 29.41 | 26.01 | 17 | 16395 | 2517 | 34938002 |
| Upper respiratory tract congestion | 29.31 | 26.01 | 12 | 16400 | 833 | 34939686 |
| Nausea | 28.94 | 26.01 | 74 | 16338 | 339834 | 34600685 |
| White blood cell count decreased | 28.89 | 26.01 | 5 | 16407 | 95440 | 34845079 |
| Pancytopenia | 28.77 | 26.01 | 5 | 16407 | 95152 | 34845367 |
| Blood creatinine increased | 28.70 | 26.01 | 5 | 16407 | 94971 | 34845548 |
| Oropharyngeal pain | 28.60 | 26.01 | 56 | 16356 | 35429 | 34905090 |
| Systolic dysfunction | 28.36 | 26.01 | 17 | 16395 | 2691 | 34937828 |
| Cardiac septal defect | 28.02 | 26.01 | 9 | 16403 | 310 | 34940209 |
| Dehydration | 27.99 | 26.01 | 13 | 16399 | 129956 | 34810563 |
| Confusional state | 27.27 | 26.01 | 17 | 16395 | 144143 | 34796376 |
| Hypoventilation | 27.15 | 26.01 | 18 | 16394 | 3396 | 34937123 |
| Hypohidrosis | 26.90 | 26.01 | 8 | 16404 | 212 | 34940307 |
| Vomiting | 26.84 | 26.01 | 47 | 16365 | 247574 | 34692945 |
| Renal failure | 26.69 | 26.01 | 14 | 16398 | 130543 | 34809976 |
| Lip swelling | 26.26 | 26.01 | 35 | 16377 | 16045 | 34924474 |
| Myocardial infarction | 26.24 | 26.01 | 12 | 16400 | 121073 | 34819446 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Asthma | 3740.60 | 19.06 | 1730 | 44285 | 133365 | 79565008 |
| Wheezing | 2245.62 | 19.06 | 1168 | 44847 | 115496 | 79582877 |
| Obstructive airways disorder | 1666.04 | 19.06 | 641 | 45374 | 30818 | 79667555 |
| Full blood count abnormal | 1036.27 | 19.06 | 493 | 45522 | 39981 | 79658392 |
| Therapeutic product effect incomplete | 1008.01 | 19.06 | 754 | 45261 | 140891 | 79557482 |
| Sleep disorder due to a general medical condition | 897.17 | 19.06 | 330 | 45685 | 13947 | 79684426 |
| Productive cough | 781.06 | 19.06 | 537 | 45478 | 87794 | 79610579 |
| Cough | 704.74 | 19.06 | 957 | 45058 | 365832 | 79332541 |
| Sputum discoloured | 656.23 | 19.06 | 297 | 45718 | 21446 | 79676927 |
| Dyspnoea | 649.87 | 19.06 | 1482 | 44533 | 855543 | 78842830 |
| Forced expiratory volume decreased | 525.67 | 19.06 | 190 | 45825 | 7624 | 79690749 |
| Chest discomfort | 481.67 | 19.06 | 490 | 45525 | 137554 | 79560819 |
| Loss of personal independence in daily activities | 463.59 | 19.06 | 420 | 45595 | 102160 | 79596213 |
| Bronchiectasis | 394.53 | 19.06 | 212 | 45803 | 22174 | 79676199 |
| Breath sounds abnormal | 358.42 | 19.06 | 178 | 45837 | 15806 | 79682567 |
| Asthma-chronic obstructive pulmonary disease overlap syndrome | 357.26 | 19.06 | 114 | 45901 | 3107 | 79695266 |
| Middle insomnia | 334.04 | 19.06 | 170 | 45845 | 15899 | 79682474 |
| Nasal congestion | 315.75 | 19.06 | 298 | 45717 | 76254 | 79622119 |
| Pulmonary function test decreased | 314.55 | 19.06 | 130 | 45885 | 7507 | 79690866 |
| Nasal polyps | 272.54 | 19.06 | 116 | 45899 | 7211 | 79691162 |
| Dyspnoea exertional | 226.40 | 19.06 | 265 | 45750 | 86808 | 79611565 |
| Acute kidney injury | 210.97 | 19.06 | 26 | 45989 | 519378 | 79178995 |
| Blood immunoglobulin E increased | 205.20 | 19.06 | 89 | 45926 | 5793 | 79692580 |
| Toxicity to various agents | 195.72 | 19.06 | 12 | 46003 | 421528 | 79276845 |
| Gastrooesophageal reflux disease | 188.56 | 19.06 | 265 | 45750 | 103981 | 79594392 |
| Chronic obstructive pulmonary disease | 183.27 | 19.06 | 236 | 45779 | 85183 | 79613190 |
| Influenza | 179.67 | 19.06 | 291 | 45724 | 129315 | 79569058 |
| Pneumonia viral | 176.21 | 19.06 | 92 | 45923 | 9066 | 79689307 |
| Nasal obstruction | 173.62 | 19.06 | 60 | 45955 | 2104 | 79696269 |
| Bronchial wall thickening | 161.94 | 19.06 | 60 | 45955 | 2581 | 79695792 |
| Bronchial secretion retention | 159.37 | 19.06 | 67 | 45948 | 4037 | 79694336 |
| Rhinitis | 157.10 | 19.06 | 101 | 45914 | 14706 | 79683667 |
| Restrictive pulmonary disease | 155.62 | 19.06 | 58 | 45957 | 2537 | 79695836 |
| Total lung capacity increased | 154.98 | 19.06 | 56 | 45959 | 2242 | 79696131 |
| Bacterial disease carrier | 152.23 | 19.06 | 50 | 45965 | 1496 | 79696877 |
| Respiratory disorder | 150.28 | 19.06 | 156 | 45859 | 44700 | 79653673 |
| Upper-airway cough syndrome | 149.98 | 19.06 | 90 | 45925 | 11603 | 79686770 |
| Nasopharyngitis | 148.98 | 19.06 | 400 | 45615 | 253481 | 79444892 |
| Drug interaction | 145.66 | 19.06 | 31 | 45984 | 415152 | 79283221 |
| Illness | 145.58 | 19.06 | 156 | 45859 | 46355 | 79652018 |
| Spirometry abnormal | 144.75 | 19.06 | 43 | 45972 | 916 | 79697457 |
| Dust allergy | 144.52 | 19.06 | 48 | 45967 | 1488 | 79696885 |
| Eosinophil count increased | 143.85 | 19.06 | 101 | 45914 | 17004 | 79681369 |
| Death | 139.25 | 19.06 | 77 | 45938 | 566437 | 79131936 |
| Blood test abnormal | 138.40 | 19.06 | 100 | 45915 | 17610 | 79680763 |
| Congenital hiatus hernia | 137.79 | 19.06 | 40 | 45975 | 784 | 79697589 |
| Eosinophilia | 136.52 | 19.06 | 149 | 45866 | 45196 | 79653177 |
| Bronchial hyperreactivity | 136.28 | 19.06 | 55 | 45960 | 2985 | 79695388 |
| Rhinitis allergic | 135.90 | 19.06 | 86 | 45929 | 12183 | 79686190 |
| Diarrhoea | 135.29 | 19.06 | 187 | 45828 | 880302 | 78818071 |
| Lung diffusion test abnormal | 131.84 | 19.06 | 33 | 45982 | 357 | 79698016 |
| Mite allergy | 130.11 | 19.06 | 42 | 45973 | 1188 | 79697185 |
| Respiratory tract congestion | 129.93 | 19.06 | 101 | 45914 | 19853 | 79678520 |
| Conjunctivitis allergic | 127.65 | 19.06 | 45 | 45970 | 1675 | 79696698 |
| Glaucoma | 126.45 | 19.06 | 99 | 45916 | 19662 | 79678711 |
| Seasonal allergy | 124.48 | 19.06 | 91 | 45924 | 16315 | 79682058 |
| Heart rate increased | 119.49 | 19.06 | 234 | 45781 | 120490 | 79577883 |
| Sinus pain | 118.82 | 19.06 | 53 | 45962 | 3689 | 79694684 |
| Thrombocytopenia | 116.00 | 19.06 | 10 | 46005 | 265249 | 79433124 |
| Neutropenia | 115.21 | 19.06 | 15 | 46000 | 287695 | 79410678 |
| Bronchitis | 111.29 | 19.06 | 238 | 45777 | 130406 | 79567967 |
| Eosinophil count abnormal | 110.43 | 19.06 | 33 | 45982 | 718 | 79697655 |
| Soft tissue disorder | 109.10 | 19.06 | 49 | 45966 | 3466 | 79694907 |
| Mycotic allergy | 106.13 | 19.06 | 38 | 45977 | 1481 | 79696892 |
| Bronchial neoplasm | 104.54 | 19.06 | 29 | 45986 | 479 | 79697894 |
| Pulmonary function test abnormal | 104.43 | 19.06 | 50 | 45965 | 4094 | 79694279 |
| Nasal turbinate hypertrophy | 103.32 | 19.06 | 31 | 45984 | 684 | 79697689 |
| Sarcoidosis | 101.35 | 19.06 | 62 | 45953 | 8273 | 79690100 |
| Airway remodelling | 100.00 | 19.06 | 25 | 45990 | 269 | 79698104 |
| Sleep apnoea syndrome | 99.73 | 19.06 | 114 | 45901 | 36364 | 79662009 |
| Sinusitis | 98.87 | 19.06 | 292 | 45723 | 195209 | 79503164 |
| Crepitations | 95.70 | 19.06 | 64 | 45951 | 9953 | 79688420 |
| Secretion discharge | 95.55 | 19.06 | 75 | 45940 | 14947 | 79683426 |
| Vocal cord dysfunction | 94.67 | 19.06 | 28 | 45987 | 587 | 79697786 |
| Confusional state | 94.12 | 19.06 | 33 | 45982 | 317964 | 79380409 |
| Lower respiratory tract infection | 93.92 | 19.06 | 221 | 45794 | 128999 | 79569374 |
| Hyper IgE syndrome | 92.30 | 19.06 | 27 | 45988 | 544 | 79697829 |
| Infusion related reaction | 92.16 | 19.06 | 12 | 46003 | 230225 | 79468148 |
| Bronchospasm | 91.53 | 19.06 | 91 | 45924 | 24768 | 79673605 |
| Bronchial disorder | 91.21 | 19.06 | 39 | 45976 | 2450 | 79695923 |
| Blood pressure increased | 88.74 | 19.06 | 296 | 45719 | 211064 | 79487309 |
| Endometrial ablation | 88.40 | 19.06 | 29 | 45986 | 864 | 79697509 |
| Platelet count decreased | 86.02 | 19.06 | 7 | 46008 | 194657 | 79503716 |
| Eosinophilic granulomatosis with polyangiitis | 85.71 | 19.06 | 42 | 45973 | 3618 | 79694755 |
| Respiratory rate increased | 85.00 | 19.06 | 82 | 45933 | 21518 | 79676855 |
| Rhonchi | 84.73 | 19.06 | 43 | 45972 | 3993 | 79694380 |
| Pneumonia | 83.94 | 19.06 | 659 | 45356 | 659587 | 79038786 |
| Hypoventilation | 83.43 | 19.06 | 52 | 45963 | 7172 | 79691201 |
| Dysphonia | 83.26 | 19.06 | 131 | 45884 | 56741 | 79641632 |
| Rhinorrhoea | 82.06 | 19.06 | 153 | 45862 | 75921 | 79622452 |
| Bronchial haemorrhage | 80.97 | 19.06 | 30 | 45985 | 1290 | 79697083 |
| Sputum purulent | 80.34 | 19.06 | 30 | 45985 | 1319 | 79697054 |
| Off label use | 80.20 | 19.06 | 263 | 45752 | 906952 | 78791421 |
| White blood cell count decreased | 79.89 | 19.06 | 8 | 46007 | 188280 | 79510093 |
| Throat clearing | 79.21 | 19.06 | 36 | 45979 | 2618 | 79695755 |
| Body temperature decreased | 78.79 | 19.06 | 95 | 45920 | 32050 | 79666323 |
| Idiopathic intracranial hypertension | 78.54 | 19.06 | 38 | 45977 | 3184 | 79695189 |
| Sensitivity to weather change | 78.29 | 19.06 | 52 | 45963 | 7995 | 79690378 |
| Emphysema | 77.95 | 19.06 | 69 | 45946 | 16231 | 79682142 |
| Sinus operation | 77.73 | 19.06 | 35 | 45980 | 2490 | 79695883 |
| Superinfection | 76.87 | 19.06 | 43 | 45972 | 4859 | 79693514 |
| Chronic sinusitis | 76.37 | 19.06 | 62 | 45953 | 12964 | 79685409 |
| Hypotension | 75.22 | 19.06 | 86 | 45929 | 440231 | 79258142 |
| Broncholithiasis | 74.49 | 19.06 | 19 | 45996 | 223 | 79698150 |
| Drug abuse | 74.30 | 19.06 | 5 | 46010 | 162686 | 79535687 |
| Rash | 72.52 | 19.06 | 140 | 45875 | 578218 | 79120155 |
| Overdose | 70.44 | 19.06 | 11 | 46004 | 184195 | 79514178 |
| Cardiac murmur | 69.79 | 19.06 | 64 | 45951 | 15760 | 79682613 |
| Dehydration | 69.66 | 19.06 | 28 | 45987 | 248159 | 79450214 |
| Disease progression | 68.29 | 19.06 | 12 | 46003 | 184350 | 79514023 |
| Arthritis | 67.24 | 19.06 | 181 | 45834 | 114699 | 79583674 |
| Peak expiratory flow rate decreased | 66.89 | 19.06 | 22 | 45993 | 661 | 79697712 |
| Mycobacterium avium complex infection | 65.80 | 19.06 | 38 | 45977 | 4562 | 79693811 |
| Rib deformity | 65.34 | 19.06 | 17 | 45998 | 217 | 79698156 |
| Febrile neutropenia | 64.92 | 19.06 | 26 | 45989 | 230973 | 79467400 |
| Lymph node calcification | 64.35 | 19.06 | 19 | 45996 | 396 | 79697977 |
| Lung consolidation | 64.21 | 19.06 | 48 | 45967 | 8899 | 79689474 |
| Kyphosis | 63.37 | 19.06 | 31 | 45984 | 2660 | 79695713 |
| Ventricular failure | 63.37 | 19.06 | 20 | 45995 | 525 | 79697848 |
| Eosinophil count | 63.23 | 19.06 | 15 | 46000 | 127 | 79698246 |
| Pancytopenia | 63.14 | 19.06 | 10 | 46005 | 165735 | 79532638 |
| Neuropathy peripheral | 62.64 | 19.06 | 5 | 46010 | 141300 | 79557073 |
| Nausea | 62.19 | 19.06 | 313 | 45702 | 956883 | 78741490 |
| Pulmonary mass | 61.87 | 19.06 | 80 | 45935 | 28954 | 79669419 |
| Sepsis | 61.31 | 19.06 | 40 | 45975 | 269388 | 79428985 |
| Aspartate aminotransferase increased | 61.20 | 19.06 | 5 | 46010 | 138636 | 79559737 |
| Allergy to animal | 60.96 | 19.06 | 25 | 45990 | 1414 | 79696959 |
| Gastrointestinal haemorrhage | 60.81 | 19.06 | 7 | 46008 | 147712 | 79550661 |
| Viral infection | 60.09 | 19.06 | 97 | 45918 | 42919 | 79655454 |
| Increased bronchial secretion | 59.96 | 19.06 | 32 | 45983 | 3295 | 79695078 |
| Blood creatinine increased | 59.87 | 19.06 | 9 | 46006 | 155048 | 79543325 |
| Malignant neoplasm progression | 59.76 | 19.06 | 5 | 46010 | 135985 | 79562388 |
| Forced vital capacity decreased | 59.57 | 19.06 | 26 | 45989 | 1717 | 79696656 |
| Alanine aminotransferase increased | 59.31 | 19.06 | 11 | 46004 | 162559 | 79535814 |
| Malaise | 58.87 | 19.06 | 483 | 45532 | 489386 | 79208987 |
| Hypokalaemia | 58.86 | 19.06 | 7 | 46008 | 144033 | 79554340 |
| Intentional product use issue | 58.34 | 19.06 | 9 | 46006 | 152103 | 79546270 |
| Haemoglobin decreased | 57.69 | 19.06 | 28 | 45987 | 222091 | 79476282 |
| Reversible airways obstruction | 57.10 | 19.06 | 27 | 45988 | 2149 | 79696224 |
| Malignant melanoma in situ | 57.01 | 19.06 | 28 | 45987 | 2424 | 79695949 |
| Oropharyngeal pain | 56.82 | 19.06 | 165 | 45850 | 109188 | 79589185 |
| Arthropathy | 56.61 | 19.06 | 16 | 45999 | 177095 | 79521278 |
| Cryopyrin associated periodic syndrome | 56.37 | 19.06 | 17 | 45998 | 382 | 79697991 |
| Nicotine dependence | 56.01 | 19.06 | 21 | 45994 | 934 | 79697439 |
| Herpes zoster | 55.82 | 19.06 | 148 | 45867 | 92935 | 79605438 |
| Eczema | 55.60 | 19.06 | 91 | 45924 | 40727 | 79657646 |
| Hyponatraemia | 55.14 | 19.06 | 17 | 45998 | 177831 | 79520542 |
| Bronchial obstruction | 53.80 | 19.06 | 28 | 45987 | 2740 | 79695633 |
| Blood pressure systolic increased | 53.54 | 19.06 | 119 | 45896 | 66867 | 79631506 |
| Therapeutic product effect decreased | 52.01 | 19.06 | 15 | 46000 | 163848 | 79534525 |
| Eosinophilic pneumonia chronic | 52.00 | 19.06 | 17 | 45998 | 501 | 79697872 |
| Respiratory symptom | 51.60 | 19.06 | 33 | 45982 | 4758 | 79693615 |
| Vomiting | 51.42 | 19.06 | 204 | 45811 | 665624 | 79032749 |
| Sinus disorder | 51.19 | 19.06 | 64 | 45951 | 22400 | 79675973 |
| Contraindicated product administered | 50.78 | 19.06 | 14 | 46001 | 157524 | 79540849 |
| Rales | 50.47 | 19.06 | 60 | 45955 | 19941 | 79678432 |
| Treatment failure | 49.87 | 19.06 | 18 | 45997 | 170468 | 79527905 |
| Cardiac arrest | 48.95 | 19.06 | 19 | 45996 | 172077 | 79526296 |
| Seizure | 48.73 | 19.06 | 24 | 45991 | 188810 | 79509563 |
| Hypomania | 48.70 | 19.06 | 38 | 45977 | 7506 | 79690867 |
| Nasal mucosal disorder | 48.60 | 19.06 | 15 | 46000 | 365 | 79698008 |
| Polycystic ovaries | 48.23 | 19.06 | 29 | 45986 | 3750 | 79694623 |
| Hand deformity | 48.01 | 19.06 | 3 | 46012 | 103916 | 79594457 |
| Scoliosis | 46.89 | 19.06 | 37 | 45978 | 7427 | 79690946 |
| Renal impairment | 45.58 | 19.06 | 17 | 45998 | 157766 | 79540607 |
| Eye disorder | 44.49 | 19.06 | 61 | 45954 | 23351 | 79675022 |
| Inspiratory capacity abnormal | 44.46 | 19.06 | 11 | 46004 | 113 | 79698260 |
| Constipation | 44.37 | 19.06 | 59 | 45956 | 282991 | 79415382 |
| Diaphragmatic disorder | 43.74 | 19.06 | 21 | 45994 | 1729 | 79696644 |
| Respiratory tract inflammation | 43.42 | 19.06 | 17 | 45998 | 851 | 79697522 |
| Atopy | 42.40 | 19.06 | 14 | 46001 | 426 | 79697947 |
| Neurosensory hypoacusis | 42.19 | 19.06 | 12 | 46003 | 218 | 79698155 |
| Decreased activity | 41.96 | 19.06 | 37 | 45978 | 8657 | 79689716 |
| Weight decreased | 41.94 | 19.06 | 349 | 45666 | 354849 | 79343524 |
| Benign prostatic hyperplasia | 41.81 | 19.06 | 42 | 45973 | 11570 | 79686803 |
| Depressed level of consciousness | 41.26 | 19.06 | 4 | 46011 | 96648 | 79601725 |
| Urinary tract infection | 41.24 | 19.06 | 59 | 45956 | 274453 | 79423920 |
| Suffocation feeling | 41.06 | 19.06 | 20 | 45995 | 1700 | 79696673 |
| Asthmatic crisis | 41.03 | 19.06 | 21 | 45994 | 1985 | 79696388 |
| Rheumatoid arthritis | 40.94 | 19.06 | 36 | 45979 | 208434 | 79489939 |
| Deep vein thrombosis | 40.39 | 19.06 | 10 | 46005 | 120909 | 79577464 |
| Atelectasis | 40.05 | 19.06 | 69 | 45946 | 32188 | 79666185 |
| Sneezing | 40.02 | 19.06 | 53 | 45962 | 19630 | 79678743 |
| Glossodynia | 39.88 | 19.06 | 6 | 46009 | 103331 | 79595042 |
| Anaemia | 39.85 | 19.06 | 128 | 45887 | 444887 | 79253486 |
| Blister | 39.67 | 19.06 | 10 | 46005 | 119466 | 79578907 |
| Humidity intolerance | 39.42 | 19.06 | 13 | 46002 | 394 | 79697979 |
| Nonspecific reaction | 39.13 | 19.06 | 22 | 45993 | 2510 | 79695863 |
| Respiratory tract infection | 38.34 | 19.06 | 86 | 45929 | 48603 | 79649770 |
| Oesophageal polyp | 38.28 | 19.06 | 9 | 46006 | 73 | 79698300 |
| Multiple organ dysfunction syndrome | 38.16 | 19.06 | 11 | 46004 | 120235 | 79578138 |
| Pneumonitis | 37.73 | 19.06 | 98 | 45917 | 60762 | 79637611 |
| Throat irritation | 37.63 | 19.06 | 77 | 45938 | 40869 | 79657504 |
| Neutrophil count decreased | 37.33 | 19.06 | 5 | 46010 | 93954 | 79604419 |
| Eosinophilic bronchitis | 37.00 | 19.06 | 13 | 46002 | 479 | 79697894 |
| Lower respiratory tract congestion | 36.89 | 19.06 | 25 | 45990 | 3972 | 79694401 |
| Sputum increased | 35.92 | 19.06 | 26 | 45989 | 4587 | 79693786 |
| Septic shock | 35.85 | 19.06 | 13 | 46002 | 122788 | 79575585 |
| Oropharyngeal discomfort | 35.59 | 19.06 | 31 | 45984 | 7135 | 79691238 |
| Jaundice cholestatic | 35.56 | 19.06 | 38 | 45977 | 11246 | 79687127 |
| CFTR gene mutation | 35.33 | 19.06 | 9 | 46006 | 105 | 79698268 |
| Hyperkalaemia | 35.33 | 19.06 | 11 | 46004 | 114387 | 79583986 |
| Bradycardia | 35.31 | 19.06 | 17 | 45998 | 135540 | 79562833 |
| Cardiac failure | 35.18 | 19.06 | 23 | 45992 | 154819 | 79543554 |
| Limb injury | 35.14 | 19.06 | 62 | 45953 | 29466 | 79668907 |
| Sinus congestion | 35.07 | 19.06 | 50 | 45965 | 19846 | 79678527 |
| Pulmonary congestion | 35.00 | 19.06 | 59 | 45956 | 27041 | 79671332 |
| Decreased appetite | 34.62 | 19.06 | 93 | 45922 | 342325 | 79356048 |
| Infective exacerbation of chronic obstructive airways disease | 34.59 | 19.06 | 21 | 45994 | 2763 | 79695610 |
| Weight increased | 34.59 | 19.06 | 276 | 45739 | 277110 | 79421263 |
| Vital capacity decreased | 34.24 | 19.06 | 18 | 45997 | 1798 | 79696575 |
| Normochromic normocytic anaemia | 33.58 | 19.06 | 31 | 45984 | 7696 | 79690677 |
| Intentional product misuse | 33.52 | 19.06 | 7 | 46008 | 95158 | 79603215 |
| Affective disorder | 33.51 | 19.06 | 32 | 45983 | 8287 | 79690086 |
| Venous pressure jugular increased | 33.25 | 19.06 | 16 | 45999 | 1324 | 79697049 |
| Arteriosclerosis coronary artery | 33.22 | 19.06 | 46 | 45969 | 17770 | 79680603 |
| Asthenia | 32.70 | 19.06 | 168 | 45847 | 511521 | 79186852 |
| Lung neoplasm malignant | 32.62 | 19.06 | 58 | 45957 | 27734 | 79670639 |
| Renal failure | 32.40 | 19.06 | 41 | 45974 | 200927 | 79497446 |
| Osteoporosis | 32.39 | 19.06 | 86 | 45929 | 54026 | 79644347 |
| Impaired healing | 31.81 | 19.06 | 6 | 46009 | 87649 | 79610724 |
| Secondary immunodeficiency | 31.70 | 19.06 | 21 | 45994 | 3213 | 79695160 |
| Granuloma | 31.70 | 19.06 | 31 | 45984 | 8266 | 79690107 |
| Muscle tension dysphonia | 31.56 | 19.06 | 9 | 46006 | 165 | 79698208 |
| Wall motion score index abnormal | 31.16 | 19.06 | 9 | 46006 | 173 | 79698200 |
| Stress | 31.16 | 19.06 | 109 | 45906 | 79503 | 79618870 |
| Central nervous system mass | 31.12 | 19.06 | 9 | 46006 | 174 | 79698199 |
| Hypersensitivity | 31.10 | 19.06 | 258 | 45757 | 261981 | 79436392 |
| Abdominal discomfort | 31.07 | 19.06 | 61 | 45954 | 250666 | 79447707 |
| Coma | 30.51 | 19.06 | 10 | 46005 | 100639 | 79597734 |
| Frustration tolerance decreased | 30.49 | 19.06 | 29 | 45986 | 7473 | 79690900 |
| Ascites | 30.06 | 19.06 | 4 | 46011 | 75558 | 79622815 |
| Rib fracture | 29.86 | 19.06 | 56 | 45959 | 27891 | 79670482 |
| Cognitive disorder | 29.57 | 19.06 | 3 | 46012 | 69923 | 79628450 |
| Eye pruritus | 29.56 | 19.06 | 47 | 45968 | 20523 | 79677850 |
| Vascular shunt | 29.54 | 19.06 | 7 | 46008 | 59 | 79698314 |
| Exposure to allergen | 29.48 | 19.06 | 10 | 46005 | 331 | 79698042 |
| Helicobacter infection | 29.45 | 19.06 | 3 | 46012 | 69701 | 79628672 |
| Chest X-ray abnormal | 29.28 | 19.06 | 29 | 45986 | 7854 | 79690519 |
| FEV1/FVC ratio decreased | 29.01 | 19.06 | 9 | 46006 | 223 | 79698150 |
| Transient ischaemic attack | 28.80 | 19.06 | 81 | 45934 | 52614 | 79645759 |
| Fibromyalgia | 28.65 | 19.06 | 92 | 45923 | 64248 | 79634125 |
| Rectal prolapse | 28.54 | 19.06 | 17 | 45998 | 2161 | 79696212 |
| International normalised ratio increased | 28.30 | 19.06 | 7 | 46008 | 84714 | 79613659 |
| Angioplasty | 28.28 | 19.06 | 16 | 45999 | 1847 | 79696526 |
| Respiration abnormal | 27.73 | 19.06 | 28 | 45987 | 7760 | 79690613 |
| Nocturnal dyspnoea | 27.52 | 19.06 | 15 | 46000 | 1611 | 79696762 |
| Ankle fracture | 27.52 | 19.06 | 41 | 45974 | 16928 | 79681445 |
| Pleural effusion | 27.42 | 19.06 | 26 | 45989 | 145236 | 79553137 |
| Alopecia | 27.21 | 19.06 | 58 | 45957 | 231297 | 79467076 |
| Oral pain | 27.12 | 19.06 | 58 | 45957 | 31740 | 79666633 |
| Rhabdomyolysis | 26.76 | 19.06 | 13 | 46002 | 103118 | 79595255 |
| Agitation | 26.75 | 19.06 | 12 | 46003 | 99703 | 79598670 |
| Hepatic function abnormal | 26.54 | 19.06 | 5 | 46010 | 73102 | 79625271 |
| Lipohypertrophy | 26.41 | 19.06 | 12 | 46003 | 872 | 79697501 |
| Total lung capacity decreased | 26.41 | 19.06 | 18 | 45997 | 2887 | 79695486 |
| Lung disorder | 26.27 | 19.06 | 104 | 45911 | 80453 | 79617920 |
| Peak expiratory flow rate abnormal | 26.24 | 19.06 | 7 | 46008 | 99 | 79698274 |
| Schizophrenia | 26.04 | 19.06 | 38 | 45977 | 15402 | 79682971 |
| Breast neoplasm | 25.80 | 19.06 | 12 | 46003 | 920 | 79697453 |
| Ocular discomfort | 25.65 | 19.06 | 22 | 45993 | 4961 | 79693412 |
| Cardiac septal defect | 25.58 | 19.06 | 9 | 46006 | 333 | 79698040 |
| Hypercholesterolaemia | 25.58 | 19.06 | 47 | 45968 | 23048 | 79675325 |
| Skin lesion | 25.55 | 19.06 | 67 | 45948 | 41777 | 79656596 |
| Loss of consciousness | 25.30 | 19.06 | 36 | 45979 | 167907 | 79530466 |
| Psoriasis | 25.29 | 19.06 | 10 | 46005 | 89577 | 79608796 |
| Psoriatic arthropathy | 25.00 | 19.06 | 7 | 46008 | 77992 | 79620381 |
| Psychotic disorder | 24.98 | 19.06 | 66 | 45949 | 41336 | 79657037 |
| Croup infectious | 24.94 | 19.06 | 11 | 46004 | 745 | 79697628 |
| Hepatic failure | 24.94 | 19.06 | 3 | 46012 | 61209 | 79637164 |
| Therapy non-responder | 24.93 | 19.06 | 11 | 46004 | 92294 | 79606079 |
| Fear of disease | 24.91 | 19.06 | 13 | 46002 | 1279 | 79697094 |
| Infection | 24.61 | 19.06 | 230 | 45785 | 241482 | 79456891 |
| Nodule | 24.47 | 19.06 | 46 | 45969 | 22948 | 79675425 |
| Granulomatosis with polyangiitis | 24.25 | 19.06 | 17 | 45998 | 2853 | 79695520 |
| Oral candidiasis | 24.08 | 19.06 | 53 | 45962 | 29575 | 79668798 |
| Ligament pain | 24.02 | 19.06 | 8 | 46007 | 250 | 79698123 |
| Blood alkaline phosphatase increased | 23.88 | 19.06 | 4 | 46011 | 63660 | 79634713 |
| Choking | 23.70 | 19.06 | 32 | 45983 | 12069 | 79686304 |
| Allergic sinusitis | 23.50 | 19.06 | 11 | 46004 | 856 | 79697517 |
| Irritable bowel syndrome | 23.15 | 19.06 | 4 | 46011 | 62237 | 79636136 |
| Obstruction | 23.01 | 19.06 | 20 | 45995 | 4590 | 79693783 |
| Respiratory arrest | 23.01 | 19.06 | 3 | 46012 | 57547 | 79640826 |
| Drug-induced liver injury | 23.00 | 19.06 | 5 | 46010 | 66112 | 79632261 |
| Lung opacity | 22.96 | 19.06 | 21 | 45994 | 5153 | 79693220 |
| Hypohidrosis | 22.92 | 19.06 | 8 | 46007 | 289 | 79698084 |
| Osteopenia | 22.42 | 19.06 | 39 | 45976 | 18325 | 79680048 |
| Medication error | 22.30 | 19.06 | 6 | 46009 | 68636 | 79629737 |
| Respiratory failure | 21.56 | 19.06 | 45 | 45970 | 180866 | 79517507 |
| Pneumonia aspiration | 21.48 | 19.06 | 6 | 46009 | 66961 | 79631412 |
| Forearm fracture | 21.42 | 19.06 | 9 | 46006 | 541 | 79697832 |
| Somnolence | 21.17 | 19.06 | 69 | 45946 | 238912 | 79459461 |
| Electrocardiogram QT prolonged | 21.11 | 19.06 | 13 | 46002 | 90373 | 79608000 |
| Fluid retention | 21.04 | 19.06 | 7 | 46008 | 69802 | 79628571 |
| Suicidal ideation | 20.77 | 19.06 | 9 | 46006 | 76331 | 79622042 |
| Eosinophilic pneumonia | 20.59 | 19.06 | 20 | 45995 | 5290 | 79693083 |
| Soft tissue swelling | 20.41 | 19.06 | 12 | 46003 | 1489 | 79696884 |
| Oesophagogastroduodenoscopy | 20.40 | 19.06 | 7 | 46008 | 240 | 79698133 |
| Fibromuscular dysplasia | 20.37 | 19.06 | 7 | 46008 | 241 | 79698132 |
| Hypoxia | 20.24 | 19.06 | 115 | 45900 | 103128 | 79595245 |
| Dyslipidaemia | 20.15 | 19.06 | 29 | 45986 | 11604 | 79686769 |
| Abdominal pain | 20.04 | 19.06 | 137 | 45878 | 389432 | 79308941 |
| Systolic dysfunction | 20.03 | 19.06 | 17 | 45998 | 3778 | 79694595 |
| Neoplasm progression | 19.94 | 19.06 | 3 | 46012 | 51679 | 79646694 |
| Hepatitis | 19.83 | 19.06 | 4 | 46011 | 55723 | 79642650 |
| Adverse drug reaction | 19.50 | 19.06 | 83 | 45932 | 66309 | 79632064 |
| Forced expiratory flow decreased | 19.33 | 19.06 | 7 | 46008 | 282 | 79698091 |
| Pleural thickening | 19.20 | 19.06 | 15 | 46000 | 2967 | 79695406 |
| Pleural rub | 19.13 | 19.06 | 5 | 46010 | 65 | 79698308 |
| Metabolic acidosis | 19.10 | 19.06 | 12 | 46003 | 82517 | 79615856 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R01AD13 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids |
| ATC | R03BA08 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS Glucocorticoids |
| MeSH PA | D018926 | Anti-Allergic Agents |
| MeSH PA | D005938 | Glucocorticoids |
| MeSH PA | D006728 | Hormones |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Allergic rhinitis | indication | 61582004 | |
| Asthma | indication | 195967001 | DOID:2841 |
| Seasonal allergic rhinitis | indication | 367498001 | |
| Asthma management | indication | 406162001 | |
| Severe chronic obstructive pulmonary disease | off-label use | 313299006 | |
| Mycosis | contraindication | 3218000 | DOID:1564 |
| Ocular hypertension | contraindication | 4210003 | DOID:9282 |
| Inactive tuberculosis | contraindication | 11999007 | |
| Epistaxis | contraindication | 12441001 | |
| Disease caused by parasite | contraindication | 17322007 | |
| Glaucoma | contraindication | 23986001 | DOID:1686 |
| Acute tuberculosis | contraindication | 25629007 | |
| Osteoporosis | contraindication | 64859006 | DOID:11476 |
| Operation on nose | contraindication | 88733004 | |
| Bilateral cataracts | contraindication | 95722004 | |
| Ophthalmic herpes simplex | contraindication | 186542001 | |
| Osteopenia | contraindication | 312894000 | |
| Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
| Nasal Candidiasis | contraindication | ||
| Oropharyngeal Candidiasis | contraindication | ||
| Nasal Trauma | contraindication | ||
| Uncontrolled Bacterial Infections | contraindication | ||
| Nasal Septal Ulcers | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Aservo EquiHaler | Boehringer lngelheim Animal Health USA Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.78 | acidic |
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 0.08MG/INH | ALVESCO | COVIS | N021658 | Jan. 10, 2008 | RX | AEROSOL, METERED | INHALATION | 8371292 | Feb. 1, 2028 | MAINTENANCE TREATMENT OF ASTHMA AS PROPHYLACTIC THERAPY IN ADULT AND ADOLESCENT PATIENTS 12 YEARS OF AGE AND OLDER. PATENT CLAIMS METHOD FOR TREATING A RESPIRATORY DISEASE IN A CHILD |
| 0.16MG/INH | ALVESCO | COVIS | N021658 | Jan. 10, 2008 | RX | AEROSOL, METERED | INHALATION | 8371292 | Feb. 1, 2028 | MAINTENANCE TREATMENT OF ASTHMA AS PROPHYLACTIC THERAPY IN ADULT AND ADOLESCENT PATIENTS 12 YEARS OF AGE AND OLDER. PATENT CLAIMS METHOD FOR TREATING A RESPIRATORY DISEASE IN A CHILD |
| 0.05MG/SPRAY | OMNARIS | COVIS | N022004 | Oct. 20, 2006 | RX | SPRAY, METERED | NASAL | 8371292 | Feb. 1, 2028 | TREATMENT OF NASAL SYMPTOMS ASSOCIATED WITH SEASONAL ALLERGIC RHINITIS IN ADULTS AND CHILDREN 6 YEARS OF AGE AND OLDER. TREATMENT OF NASAL SYMPTOMS ASSOCIATED W PERENNIAL ALLERGIC RHINITIS IN ADULTS AND ADOLESCENTS 12 YEARS OF AGE AND OLDER |
| 0.037MG/INH | ZETONNA | COVIS | N202129 | Jan. 20, 2012 | RX | AEROSOL, METERED | NASAL | 8371292 | Feb. 1, 2028 | TREATMENT OF SYMPTOMS ASSOCIATED WITH SEASONAL AND PERENNIAL ALLERGIC RHINITIS IN ADULTS AND ADOLESCENTS 12 YEARS OF AGE AND OLDER. PATENT CLAIMS METHODS FOR TREATING A RESPIRATORY DISEASE IN A CHILD |
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | Ki | 7.43 | WOMBAT-PK | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4027427 | VUID |
| N0000179737 | NUI |
| D01703 | KEGG_DRUG |
| 274964 | RXNORM |
| 4027427 | VANDF |
| C0907850 | UMLSCUI |
| CHEBI:31397 | CHEBI |
| CHEMBL2040682 | ChEMBL_ID |
| DB01410 | DRUGBANK_ID |
| C120481 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7469 | IUPHAR_LIGAND_ID |
| 6546 | INN_ID |
| S59502J185 | UNII |
| 6918155 | PUBCHEM_CID |
| 132906 | MMSL |
| 19358 | MMSL |
| 89965 | MMSL |
| d05465 | MMSL |
| 008829 | NDDF |
| 416739001 | SNOMEDCT_US |
| 417420004 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Alvesco | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5989 | AEROSOL, METERED | 80 ug | RESPIRATORY (INHALATION) | NDA | 27 sections |
| Alvesco | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5990 | AEROSOL, METERED | 160 ug | RESPIRATORY (INHALATION) | NDA | 27 sections |
| Omnaris | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-6020 | SPRAY | 50 ug | NASAL | NDA | 13 sections |
| Omnaris | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70515-701 | SPRAY | 50 ug | NASAL | NDA | 27 sections |
| Omnaris | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70515-701 | SPRAY | 50 ug | NASAL | NDA | 27 sections |
| Alvesco | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70515-711 | AEROSOL, METERED | 80 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
| Alvesco | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70515-711 | AEROSOL, METERED | 80 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
| Alvesco | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70515-712 | AEROSOL, METERED | 160 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
| Alvesco | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70515-712 | AEROSOL, METERED | 160 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
| Zetonna | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70515-737 | AEROSOL, METERED | 37 ug | NASAL | NDA | 28 sections |
| Zetonna | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70515-737 | AEROSOL, METERED | 37 ug | NASAL | NDA | 28 sections |