Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, 6-aminopenicillanic acid derivatives | 632 | 3485-14-1 |
None
Property | Value | Reference |
---|---|---|
MRTD (Maximum Recommended Therapeutic Daily Dose) | 97.53 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 13, 1979 | FDA | WYETH AYERST |
None
None
None
None
Source | Code | Description |
---|---|---|
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Bronchitis | indication | 32398004 | DOID:6132 |
Urinary tract infectious disease | indication | 68566005 | |
Infective otitis media | indication | 312218008 | |
Pharyngitis | indication | 405737000 | DOID:2275 |
Sinusitis | off-label use | 36971009 | |
Cholangitis | off-label use | 82403002 | DOID:9446 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Infectious mononucleosis | contraindication | 271558008 | DOID:8568 |
Pseudomembranous enterocolitis | contraindication | 397683000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.79 | acidic |
pKa2 | 8.58 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Bacterial penicillin-binding protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
Penicillin-binding protein 1A | Enzyme | WOMBAT-PK |
ID | Source |
---|---|
4018054 | VUID |
N0000146395 | NUI |
D01334 | KEGG_DRUG |
2968 | RXNORM |
4018054 | VANDF |
CHEBI:31444 | CHEBI |
CHEMBL1200356 | ChEMBL_ID |
4817 | IUPHAR_LIGAND_ID |
2764 | INN_ID |
DB01000 | DRUGBANK_ID |
72ZJ154X86 | UNII |
002696 | NDDF |
387382002 | SNOMEDCT_US |
69331001 | SNOMEDCT_US |
C0010523 | UMLSCUI |
D003493 | MESH_DESCRIPTOR_UI |
19003 | PUBCHEM_CID |
None