cyclacillin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, 6-aminopenicillanic acid derivatives 632 3485-14-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ciclacillin
  • cyclacillin
  • aminocyclohexylpenicillin
  • ciclacillum
A cyclohexylamido analog of PENICILLANIC ACID.
  • Molecular weight: 341.43
  • Formula: C15H23N3O4S
  • CLOGP: -0.82
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 112.73
  • ALOGS: -2.26
  • ROTB: 3

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 97.53 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Sept. 13, 1979 FDA WYETH AYERST

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:36047 antibacterial drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Infection of skin AND/OR subcutaneous tissue indication 19824006
Bronchitis indication 32398004 DOID:6132
Urinary tract infectious disease indication 68566005
Infective otitis media indication 312218008
Pharyngitis indication 405737000 DOID:2275
Sinusitis off-label use 36971009
Cholangitis off-label use 82403002 DOID:9446
Kidney disease contraindication 90708001 DOID:557
Infectious mononucleosis contraindication 271558008 DOID:8568
Pseudomembranous enterocolitis contraindication 397683000




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.79 acidic
pKa2 8.58 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Bacterial penicillin-binding protein Enzyme INHIBITOR CHEMBL CHEMBL
Penicillin-binding protein 1A Enzyme WOMBAT-PK

External reference:

IDSource
4018054 VUID
N0000146395 NUI
D01334 KEGG_DRUG
2968 RXNORM
4018054 VANDF
CHEBI:31444 CHEBI
CHEMBL1200356 ChEMBL_ID
4817 IUPHAR_LIGAND_ID
2764 INN_ID
DB01000 DRUGBANK_ID
72ZJ154X86 UNII
002696 NDDF
387382002 SNOMEDCT_US
69331001 SNOMEDCT_US
C0010523 UMLSCUI
D003493 MESH_DESCRIPTOR_UI
19003 PUBCHEM_CID

Pharmaceutical products:

None