cibenzoline Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
630 53267-01-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cifenline
  • cibenzoline
  • (RS)-Cibenzoline
  • (+/-)-Cibenzoline
  • cibenzoline succinate
  • cifenline succinate
  • Molecular weight: 262.36
  • Formula: C18H18N2
  • CLOGP: 4.13
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 24.39
  • ALOGS: -4.73
  • ROTB: 3

Drug dosage:

None

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 24.78 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 86 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 4.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 8.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.50 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1978 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01BG07 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
ANTIARRHYTHMICS, CLASS I AND III
Other antiarrhythmics, class I and III
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002317 Cardiovascular Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.1 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.06 CHEMBL
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Ion channel IC50 4.33 WOMBAT-PK
ATP-sensitive inward rectifier potassium channel 11 Ion channel WOMBAT-PK

External reference:

IDSource
D01455 KEGG_DRUG
100678-32-8 SECONDARY_CAS_RN
C0055720 UMLSCUI
CHEBI:135083 CHEBI
CHEMBL87045 ChEMBL_ID
CHEMBL2106074 ChEMBL_ID
DB13358 DRUGBANK_ID
C032151 MESH_SUPPLEMENTAL_RECORD_UI
2747 PUBCHEM_CID
4568 INN_ID
Z7489237QT UNII
21099 RXNORM
004286 NDDF
004287 NDDF
719682001 SNOMEDCT_US
735065001 SNOMEDCT_US

Pharmaceutical products:

None