All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

cianidanol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	629	154-23-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: cianidanol catechin catechinic acid catechuic acid cyanidanol cyanidol dexcyanidanol	An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms. Molecular weight: 290.27 Formula: C15H14O6 CLOGP: 0.53 LIPINSKI: 0 HAC: 6 HDO: 5 TPSA: 110.38 ALOGS: -2.65 ROTB: 1

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AURKB,AURKC,AXL,BMX,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK19,CDK2,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FGFR1,FLT1,FLT3,FLT4,GRK2,GRK3,GSK3B,IRAK1,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K1,MAP3K10,MAP3K14,MAP3K2,MAP3K21,MAP3K3,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK10,MAPK12,MAPK14,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MELK,MTOR,NTRK1,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM1,PIM2,PIM3,PLK1,PRKCD,PRKDC,PTK2,SGK1,SIK2,SIK3,STK10,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70	92
kinase-selectivity-class	ACVR2B,AXL,BMX,CDK9,DYRK1B,EIF2AK3,GRK2,MAP2K6,MAP3K14,MAPK7,MAPK8,PIK3CB,PIK3CD,PLK2,PRKDC,SIK2,STK33,TEK,TGFBR1	19
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:22586	antioxidants
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:25212	metabolites
CHEBI has role	CHEBI:63726	neuroprotective agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Condyloma acuminatum	indication	240542006	DOID:11168
Poisoning by digitalis glycoside	contraindication	12876009
Constipation	contraindication	14760008	DOID:2089
Sarcoidosis	contraindication	31541009	DOID:11335
Hypercalcemia	contraindication	66931009	DOID:12678
Hypercalciuria	contraindication	71938000
Kidney disease	contraindication	90708001	DOID:557
Kidney stone	contraindication	95570007
Open wound	contraindication	125643001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	6.74	acidic
pKa2	9.15	acidic
pKa3	11.44	acidic
pKa4	12.17	acidic
pKa5	13.78	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Beta-secretase 1	Enzyme	P56817	BACE1_HUMAN		IC50	4.52		CHEMBL
Prostaglandin G/H synthase 2	Enzyme	P35354	PGH2_HUMAN		IC50	4.03		CHEMBL
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN		IC50	4.44		CHEMBL
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN		Ki	5.74		CHEMBL
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN		Ki	5.62		CHEMBL
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN		Ki	5.31		CHEMBL
Carbonic anhydrase 9	Enzyme	Q16790	CAH9_HUMAN		Ki	5.30		CHEMBL
Carbonic anhydrase 12	Enzyme	O43570	CAH12_HUMAN		Ki	5.33		CHEMBL
Prothrombin	Enzyme	P00734	THRB_HUMAN		Kd	4.31		CHEMBL
Melatonin receptor type 1A	GPCR	P48039	MTR1A_HUMAN		IC50	4.59		CHEMBL
Melatonin receptor type 1B	GPCR	P49286	MTR1B_HUMAN		IC50	4.33		CHEMBL
Mast/stem cell growth factor receptor Kit	Kinase	P10721	KIT_HUMAN		IC50	4.80		CHEMBL
Carbonic anhydrase 5A, mitochondrial	Enzyme	P35218	CAH5A_HUMAN		Ki	5.38		CHEMBL
Carbonic anhydrase 5B, mitochondrial	Enzyme	Q9Y2D0	CAH5B_HUMAN		Ki	5.40		CHEMBL
Carbonic anhydrase 7	Enzyme	P43166	CAH7_HUMAN		Ki	6.35		CHEMBL
72 kDa type IV collagenase	Enzyme	P08253	MMP2_HUMAN		IC50	4.65		CHEMBL
Carbonic anhydrase 3	Enzyme	P07451	CAH3_HUMAN		Ki	5.45		CHEMBL
Stromelysin-1	Enzyme	P08254	MMP3_HUMAN		IC50	4.47		CHEMBL
Carbonic anhydrase 6	Enzyme	P23280	CAH6_HUMAN		Ki	5.31		CHEMBL
Carbonic anhydrase 14	Enzyme	Q9ULX7	CAH14_HUMAN		Ki	4.94		CHEMBL
Matrix metalloproteinase-9	Enzyme	P14780	MMP9_HUMAN		IC50	4.50		CHEMBL
Macrophage metalloelastase	Enzyme	P39900	MMP12_HUMAN		IC50	5.24		CHEMBL
Collagenase 3	Enzyme	P45452	MMP13_HUMAN		IC50	4.46		CHEMBL
Carbonic anhydrase 13	Enzyme	Q8N1Q1	CAH13_HUMAN		Ki	4.98		CHEMBL
Amyloid beta A4 protein	Membrane other	P05067	A4_HUMAN		IC50	4.48		CHEMBL
Sclerostin	Glycoprotein	Q9BQB4	SOST_HUMAN		Kd	5.80		CHEMBL
Pyruvate kinase PKM	Enzyme	P14618	KPYM_HUMAN		IC50	5.94		CHEMBL
Prostaglandin G/H synthase 1	Enzyme		PGH1_SHEEP		Kd	4.39		CHEMBL
Polyphenol oxidase 2	Enzyme		PPO2_AGABI		Ki	5.07		CHEMBL
Carbonic anhydrase 15	Enzyme		CAH15_MOUSE		Ki	5.11		CHEMBL
Prostaglandin G/H synthase 1	Enzyme		PGH1_BOVIN		IC50	4.10		CHEMBL
Arginase	Enzyme		O96394_LEIAM		Ki	6.22		CHEMBL
P-glycoprotein 3	Transporter		MDR1A_MOUSE		Kd	4.43		CHEMBL
Dihydroorotate dehydrogenase	Enzyme		Q4QEW7_LEIMA		IC50	4.01		CHEMBL

External reference:

ID	Source
4028923	VUID
N0000179809	NUI
D00200	KEGG_DRUG
1367177	RXNORM
C0007404	UMLSCUI
CHEBI:15600	CHEBI
CHEMBL311498	ChEMBL_ID
DB14086	DRUGBANK_ID
CHEMBL206452	ChEMBL_ID
9064	PUBCHEM_CID
4804	INN_ID
8R1V1STN48	UNII
008593	NDDF
423247009	SNOMEDCT_US
423717008	SNOMEDCT_US
D002392	MESH_DESCRIPTOR_UI
KXN	PDB_CHEM_ID
13091	IUPHAR_LIGAND_ID
4028923	VANDF
8R1V1STN48	INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Slim 2	HUMAN OTC DRUG LABEL	1	60314-1001	POWDER	0.45 g	ORAL	unapproved drug other	8 sections