Stem definition | Drug id | CAS RN |
---|---|---|
621 | 50-53-3 |
Dose | Unit | Route |
---|---|---|
0.30 | g | O |
0.10 | g | P |
0.30 | g | R |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 50 mg/mL | Bocci G, Oprea TI, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 52.37 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 25 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 10 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 16 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.06 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 11 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 18, 1957 | FDA | GLAXOSMITHKLINE |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuroleptic malignant syndrome | 238.96 | 21.66 | 81 | 8334 | 11975 | 63468632 |
Sopor | 207.75 | 21.66 | 86 | 8329 | 22078 | 63458529 |
Drug abuse | 188.22 | 21.66 | 118 | 8297 | 72400 | 63408207 |
Toxicity to various agents | 172.87 | 21.66 | 187 | 8228 | 247063 | 63233544 |
Electrocardiogram QT prolonged | 139.82 | 21.66 | 91 | 8324 | 59439 | 63421168 |
Catatonia | 133.35 | 21.66 | 41 | 8374 | 4436 | 63476171 |
Overdose | 119.16 | 21.66 | 108 | 8307 | 114970 | 63365637 |
Suicide attempt | 111.85 | 21.66 | 80 | 8335 | 60838 | 63419769 |
Aggression | 97.65 | 21.66 | 52 | 8363 | 23446 | 63457161 |
Intentional self-injury | 93.30 | 21.66 | 52 | 8363 | 25635 | 63454972 |
Coma | 90.34 | 21.66 | 72 | 8343 | 64292 | 63416315 |
Agitation | 86.34 | 21.66 | 68 | 8347 | 59689 | 63420918 |
Mania | 73.85 | 21.66 | 35 | 8380 | 12332 | 63468275 |
Intentional overdose | 67.80 | 21.66 | 65 | 8350 | 74087 | 63406520 |
Psychotic disorder | 66.98 | 21.66 | 42 | 8373 | 25670 | 63454937 |
Mental disorder | 64.18 | 21.66 | 41 | 8374 | 25878 | 63454729 |
Poisoning deliberate | 61.67 | 21.66 | 30 | 8385 | 11188 | 63469419 |
Tardive dyskinesia | 59.93 | 21.66 | 27 | 8388 | 8475 | 63472132 |
Depressed level of consciousness | 59.76 | 21.66 | 56 | 8359 | 62022 | 63418585 |
Delusion | 59.71 | 21.66 | 30 | 8385 | 11987 | 63468620 |
Sedation | 57.84 | 21.66 | 45 | 8370 | 38764 | 63441843 |
Completed suicide | 56.13 | 21.66 | 82 | 8333 | 145591 | 63335016 |
Hallucination, auditory | 55.01 | 21.66 | 29 | 8386 | 12795 | 63467812 |
Psychomotor hyperactivity | 54.10 | 21.66 | 27 | 8388 | 10636 | 63469971 |
Drug interaction | 49.83 | 21.66 | 100 | 8315 | 229031 | 63251576 |
Cardiac arrest | 49.25 | 21.66 | 61 | 8354 | 92484 | 63388123 |
Stereotypy | 46.65 | 21.66 | 11 | 8404 | 431 | 63480176 |
Somnolence | 44.98 | 21.66 | 83 | 8332 | 178602 | 63302005 |
Pneumonia aspiration | 44.96 | 21.66 | 37 | 8378 | 34503 | 63446104 |
Mutism | 44.63 | 21.66 | 14 | 8401 | 1616 | 63478991 |
Wrong patient received product | 44.36 | 21.66 | 15 | 8400 | 2192 | 63478415 |
Behaviour disorder | 42.53 | 21.66 | 16 | 8399 | 3183 | 63477424 |
Hepatocellular injury | 41.33 | 21.66 | 32 | 8383 | 27349 | 63453258 |
Salivary hypersecretion | 40.63 | 21.66 | 20 | 8395 | 7646 | 63472961 |
Torsade de pointes | 40.38 | 21.66 | 24 | 8391 | 13327 | 63467280 |
Arthralgia | 39.87 | 21.66 | 13 | 8402 | 569697 | 62910910 |
Grandiosity | 39.84 | 21.66 | 9 | 8406 | 291 | 63480316 |
Miosis | 38.43 | 21.66 | 19 | 8396 | 7334 | 63473273 |
Pain | 37.94 | 21.66 | 26 | 8389 | 740602 | 62740005 |
Hallucinations, mixed | 36.16 | 21.66 | 16 | 8399 | 4813 | 63475794 |
Hypotonia neonatal | 35.36 | 21.66 | 11 | 8404 | 1235 | 63479372 |
Disorganised speech | 35.20 | 21.66 | 11 | 8404 | 1254 | 63479353 |
Tachycardia | 35.03 | 21.66 | 59 | 8356 | 118097 | 63362510 |
Epileptic encephalopathy | 34.56 | 21.66 | 8 | 8407 | 289 | 63480318 |
Abnormal behaviour | 34.45 | 21.66 | 26 | 8389 | 21400 | 63459207 |
Gaze palsy | 33.94 | 21.66 | 11 | 8404 | 1409 | 63479198 |
Eosinophilic myocarditis | 33.35 | 21.66 | 9 | 8406 | 611 | 63479996 |
Altered state of consciousness | 32.77 | 21.66 | 27 | 8388 | 25203 | 63455404 |
Psychomotor skills impaired | 32.05 | 21.66 | 12 | 8403 | 2356 | 63478251 |
Lactate pyruvate ratio increased | 30.95 | 21.66 | 6 | 8409 | 90 | 63480517 |
Fatigue | 30.73 | 21.66 | 44 | 8371 | 887984 | 62592623 |
Muscle rigidity | 30.48 | 21.66 | 19 | 8396 | 11481 | 63469126 |
Pain in extremity | 30.45 | 21.66 | 4 | 8411 | 331482 | 63149125 |
Premature delivery | 30.44 | 21.66 | 28 | 8387 | 30253 | 63450354 |
Illusion | 28.50 | 21.66 | 9 | 8406 | 1061 | 63479546 |
Extrapyramidal disorder | 27.97 | 21.66 | 19 | 8396 | 13265 | 63467342 |
Dyspnoea | 27.91 | 21.66 | 28 | 8387 | 661285 | 62819322 |
Tremor | 27.84 | 21.66 | 57 | 8358 | 132182 | 63348425 |
Confusional state | 27.42 | 21.66 | 81 | 8334 | 236299 | 63244308 |
Dysarthria | 27.41 | 21.66 | 31 | 8384 | 42680 | 63437927 |
Blood citric acid increased | 26.91 | 21.66 | 5 | 8410 | 59 | 63480548 |
Anger | 26.67 | 21.66 | 18 | 8397 | 12438 | 63468169 |
Cardio-respiratory arrest | 26.38 | 21.66 | 36 | 8379 | 59923 | 63420684 |
Swelling | 26.07 | 21.66 | 3 | 8412 | 275375 | 63205232 |
Onychophagia | 25.98 | 21.66 | 5 | 8410 | 72 | 63480535 |
Newborn persistent pulmonary hypertension | 25.60 | 21.66 | 6 | 8409 | 229 | 63480378 |
Hypothermia | 25.26 | 21.66 | 18 | 8397 | 13563 | 63467044 |
Abdominal discomfort | 24.86 | 21.66 | 6 | 8409 | 320879 | 63159728 |
Myocarditis | 24.72 | 21.66 | 16 | 8399 | 10309 | 63470298 |
Otospondylomegaepiphyseal dysplasia | 24.68 | 21.66 | 5 | 8410 | 95 | 63480512 |
Blood creatine phosphokinase increased | 24.67 | 21.66 | 25 | 8390 | 30405 | 63450202 |
Schizoaffective disorder | 24.11 | 21.66 | 11 | 8404 | 3551 | 63477056 |
Drug intolerance | 23.47 | 21.66 | 6 | 8409 | 308655 | 63171952 |
Drug use disorder | 23.46 | 21.66 | 12 | 8403 | 4972 | 63475635 |
Hepatic cytolysis | 23.23 | 21.66 | 18 | 8397 | 15389 | 63465218 |
Alopecia | 23.05 | 21.66 | 8 | 8407 | 337528 | 63143079 |
Mitochondrial enzyme deficiency | 22.93 | 21.66 | 4 | 8411 | 32 | 63480575 |
Bradyphrenia | 22.29 | 21.66 | 13 | 8402 | 6967 | 63473640 |
Seizure | 22.04 | 21.66 | 52 | 8363 | 132582 | 63348025 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuroleptic malignant syndrome | 325.63 | 17.78 | 143 | 10865 | 17791 | 34928132 |
Emotional poverty | 163.93 | 17.78 | 38 | 10970 | 560 | 34945363 |
Psychotic disorder | 156.81 | 17.78 | 97 | 10911 | 24355 | 34921568 |
Extrapyramidal disorder | 153.96 | 17.78 | 77 | 10931 | 12803 | 34933120 |
Delusion of grandeur | 116.03 | 17.78 | 33 | 10975 | 1127 | 34944796 |
Catatonia | 114.06 | 17.78 | 47 | 10961 | 4978 | 34940945 |
Decreased eye contact | 102.12 | 17.78 | 25 | 10983 | 470 | 34945453 |
Oppositional defiant disorder | 99.55 | 17.78 | 25 | 10983 | 524 | 34945399 |
Psychomotor hyperactivity | 98.96 | 17.78 | 52 | 10956 | 9570 | 34936353 |
Aggression | 93.98 | 17.78 | 86 | 10922 | 38878 | 34907045 |
Sedation | 90.30 | 17.78 | 65 | 10943 | 20941 | 34924982 |
Hallucination, auditory | 85.93 | 17.78 | 51 | 10957 | 11866 | 34934057 |
Suicide attempt | 84.09 | 17.78 | 81 | 10927 | 39035 | 34906888 |
Bruxism | 82.81 | 17.78 | 28 | 10980 | 1707 | 34944216 |
Affective disorder | 79.77 | 17.78 | 35 | 10973 | 4325 | 34941598 |
Tardive dyskinesia | 79.29 | 17.78 | 38 | 10970 | 5752 | 34940171 |
Homicidal ideation | 74.43 | 17.78 | 29 | 10979 | 2653 | 34943270 |
Neutrophil count increased | 71.28 | 17.78 | 52 | 10956 | 17094 | 34928829 |
Rhinalgia | 70.64 | 17.78 | 22 | 10986 | 1031 | 34944892 |
Foetal disorder | 67.13 | 17.78 | 20 | 10988 | 806 | 34945117 |
Parkinsonism | 67.09 | 17.78 | 38 | 10970 | 8100 | 34937823 |
Drug withdrawal syndrome neonatal | 59.63 | 17.78 | 27 | 10981 | 3592 | 34942331 |
Foetal exposure during pregnancy | 58.66 | 17.78 | 66 | 10942 | 38035 | 34907888 |
Neutropenia neonatal | 56.82 | 17.78 | 17 | 10991 | 695 | 34945228 |
Dyskinesia | 55.04 | 17.78 | 50 | 10958 | 22363 | 34923560 |
Lymphocyte count abnormal | 51.97 | 17.78 | 18 | 10990 | 1180 | 34944743 |
Priapism | 51.37 | 17.78 | 27 | 10981 | 4967 | 34940956 |
Intentional self-injury | 51.05 | 17.78 | 39 | 10969 | 13732 | 34932191 |
Choreoathetosis | 46.20 | 17.78 | 16 | 10992 | 1048 | 34944875 |
Trismus | 45.54 | 17.78 | 20 | 10988 | 2475 | 34943448 |
Overdose | 45.29 | 17.78 | 93 | 10915 | 90966 | 34854957 |
Hyperkinesia | 45.14 | 17.78 | 18 | 10990 | 1750 | 34944173 |
Salivary hypersecretion | 44.75 | 17.78 | 30 | 10978 | 8614 | 34937309 |
Schizophrenia | 44.68 | 17.78 | 30 | 10978 | 8636 | 34937287 |
Crying | 44.65 | 17.78 | 26 | 10982 | 5836 | 34940087 |
Sopor | 44.18 | 17.78 | 34 | 10974 | 12102 | 34933821 |
Dystonia | 43.05 | 17.78 | 32 | 10976 | 10813 | 34935110 |
Arthralgia | 39.28 | 17.78 | 4 | 11004 | 170037 | 34775886 |
Agitation | 38.97 | 17.78 | 67 | 10941 | 57332 | 34888591 |
Neutropenia | 38.90 | 17.78 | 123 | 10885 | 156655 | 34789268 |
Irritability | 38.37 | 17.78 | 43 | 10965 | 24647 | 34921276 |
Coordination abnormal | 38.30 | 17.78 | 26 | 10982 | 7618 | 34938305 |
Nasal discomfort | 36.17 | 17.78 | 15 | 10993 | 1613 | 34944310 |
Congenital cerebrovascular anomaly | 35.80 | 17.78 | 6 | 11002 | 12 | 34945911 |
Suicidal ideation | 35.44 | 17.78 | 53 | 10955 | 40335 | 34905588 |
Dextrocardia | 34.75 | 17.78 | 8 | 11000 | 114 | 34945809 |
SARS-CoV-2 test positive | 34.14 | 17.78 | 22 | 10986 | 5911 | 34940012 |
Speech disorder | 33.69 | 17.78 | 41 | 10967 | 25645 | 34920278 |
Antisocial personality disorder | 33.55 | 17.78 | 7 | 11001 | 61 | 34945862 |
Cerebral amyloid angiopathy | 33.54 | 17.78 | 8 | 11000 | 134 | 34945789 |
Foetal alcohol syndrome | 33.38 | 17.78 | 8 | 11000 | 137 | 34945786 |
Dyspnoea | 33.30 | 17.78 | 42 | 10966 | 376740 | 34569183 |
Blood creatine phosphokinase increased | 32.61 | 17.78 | 54 | 10954 | 44803 | 34901120 |
Affect lability | 32.53 | 17.78 | 18 | 10990 | 3665 | 34942258 |
Seizure | 32.41 | 17.78 | 89 | 10919 | 104768 | 34841155 |
Therapy non-responder | 32.40 | 17.78 | 50 | 10958 | 39096 | 34906827 |
Lymphocyte count decreased | 31.12 | 17.78 | 37 | 10971 | 22585 | 34923338 |
Poor feeding infant | 30.97 | 17.78 | 10 | 10998 | 527 | 34945396 |
Insomnia | 30.93 | 17.78 | 87 | 10921 | 103820 | 34842103 |
Pain | 30.76 | 17.78 | 13 | 10995 | 204662 | 34741261 |
Drug resistance | 30.20 | 17.78 | 39 | 10969 | 25888 | 34920035 |
Premature baby | 30.18 | 17.78 | 34 | 10974 | 19599 | 34926324 |
Intestinal obstruction | 29.23 | 17.78 | 36 | 10972 | 22786 | 34923137 |
Pain in extremity | 29.14 | 17.78 | 3 | 11005 | 126510 | 34819413 |
Treatment noncompliance | 27.74 | 17.78 | 39 | 10969 | 28061 | 34917862 |
Streptococcal infection | 27.57 | 17.78 | 18 | 10990 | 4943 | 34940980 |
Leukopenia | 27.53 | 17.78 | 61 | 10947 | 62795 | 34883128 |
Somnolence | 27.36 | 17.78 | 87 | 10921 | 111029 | 34834894 |
Floppy iris syndrome | 27.17 | 17.78 | 8 | 11000 | 309 | 34945614 |
Myocarditis | 26.88 | 17.78 | 27 | 10981 | 13655 | 34932268 |
Tachycardia | 26.23 | 17.78 | 72 | 10936 | 84700 | 34861223 |
Mood altered | 26.04 | 17.78 | 22 | 10986 | 8930 | 34936993 |
Depressed mood | 25.60 | 17.78 | 31 | 10977 | 19286 | 34926637 |
Spasmodic dysphonia | 25.07 | 17.78 | 7 | 11001 | 223 | 34945700 |
Drug withdrawal syndrome | 24.94 | 17.78 | 31 | 10977 | 19803 | 34926120 |
Respiratory depression | 24.74 | 17.78 | 28 | 10980 | 16217 | 34929706 |
Antipsychotic drug level increased | 23.90 | 17.78 | 15 | 10993 | 3850 | 34942073 |
Hiccups | 23.78 | 17.78 | 22 | 10986 | 10060 | 34935863 |
Mental impairment | 23.34 | 17.78 | 22 | 10986 | 10300 | 34935623 |
Electrocardiogram QT prolonged | 22.94 | 17.78 | 44 | 10964 | 40908 | 34905015 |
Mania | 22.91 | 17.78 | 21 | 10987 | 9490 | 34936433 |
Long QT syndrome | 22.86 | 17.78 | 13 | 10995 | 2790 | 34943133 |
Sleep disorder | 22.83 | 17.78 | 38 | 10970 | 31650 | 34914273 |
Treatment failure | 22.37 | 17.78 | 47 | 10961 | 46650 | 34899273 |
Pneumonia aspiration | 22.23 | 17.78 | 44 | 10964 | 41859 | 34904064 |
Drug interaction | 22.16 | 17.78 | 134 | 10874 | 225812 | 34720111 |
Low birth weight baby | 22.12 | 17.78 | 19 | 10989 | 7886 | 34938037 |
Acanthosis nigricans | 22.00 | 17.78 | 6 | 11002 | 175 | 34945748 |
Agranulocytosis | 21.95 | 17.78 | 32 | 10976 | 23789 | 34922134 |
Faecaloma | 21.64 | 17.78 | 16 | 10992 | 5361 | 34940562 |
Portal tract inflammation | 21.42 | 17.78 | 5 | 11003 | 76 | 34945847 |
Poor quality sleep | 21.40 | 17.78 | 19 | 10989 | 8237 | 34937686 |
Pruritus | 21.34 | 17.78 | 9 | 10999 | 141972 | 34803951 |
Neuroblastoma | 21.29 | 17.78 | 6 | 11002 | 198 | 34945725 |
Faecal vomiting | 20.57 | 17.78 | 7 | 11001 | 435 | 34945488 |
Drug screen false positive | 20.54 | 17.78 | 8 | 11000 | 731 | 34945192 |
Toxicity to various agents | 19.74 | 17.78 | 119 | 10889 | 200243 | 34745680 |
Delirium | 19.60 | 17.78 | 43 | 10965 | 43948 | 34901975 |
Electroconvulsive therapy | 19.59 | 17.78 | 4 | 11004 | 31 | 34945892 |
Unmasking of previously unidentified disease | 18.89 | 17.78 | 8 | 11000 | 906 | 34945017 |
Pulmonary valve incompetence | 18.85 | 17.78 | 8 | 11000 | 911 | 34945012 |
Intentional overdose | 18.68 | 17.78 | 42 | 10966 | 43632 | 34902291 |
Incorrect dose administered | 18.50 | 17.78 | 40 | 10968 | 40475 | 34905448 |
Poisoning deliberate | 18.27 | 17.78 | 17 | 10991 | 7827 | 34938096 |
Drug abuse | 17.83 | 17.78 | 70 | 10938 | 99026 | 34846897 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuroleptic malignant syndrome | 557.23 | 17.68 | 214 | 17223 | 27345 | 79699606 |
Catatonia | 239.53 | 17.68 | 85 | 17352 | 8671 | 79718280 |
Sopor | 222.08 | 17.68 | 119 | 17318 | 32891 | 79694060 |
Extrapyramidal disorder | 190.70 | 17.68 | 95 | 17342 | 22584 | 79704367 |
Psychotic disorder | 189.24 | 17.68 | 116 | 17321 | 41286 | 79685665 |
Aggression | 176.69 | 17.68 | 120 | 17317 | 50838 | 79676113 |
Suicide attempt | 175.04 | 17.68 | 145 | 17292 | 82787 | 79644164 |
Psychomotor hyperactivity | 160.90 | 17.68 | 77 | 17360 | 16772 | 79710179 |
Overdose | 150.36 | 17.68 | 193 | 17244 | 184013 | 79542938 |
Drug abuse | 149.65 | 17.68 | 181 | 17256 | 162510 | 79564441 |
Emotional poverty | 147.07 | 17.68 | 35 | 17402 | 852 | 79726099 |
Toxicity to various agents | 143.89 | 17.68 | 297 | 17140 | 421243 | 79305708 |
Tardive dyskinesia | 141.06 | 17.68 | 61 | 17376 | 10510 | 79716441 |
Sedation | 131.38 | 17.68 | 101 | 17336 | 51794 | 79675157 |
Hallucination, auditory | 129.12 | 17.68 | 71 | 17366 | 20622 | 79706329 |
Delusion of grandeur | 121.05 | 17.68 | 33 | 17404 | 1399 | 79725552 |
Intentional self-injury | 118.70 | 17.68 | 79 | 17358 | 32340 | 79694611 |
Oppositional defiant disorder | 111.08 | 17.68 | 25 | 17412 | 472 | 79726479 |
Electrocardiogram QT prolonged | 104.03 | 17.68 | 113 | 17324 | 90273 | 79636678 |
Agitation | 103.33 | 17.68 | 118 | 17319 | 99597 | 79627354 |
Decreased eye contact | 102.22 | 17.68 | 26 | 17411 | 839 | 79726112 |
Salivary hypersecretion | 86.52 | 17.68 | 48 | 17389 | 14176 | 79712775 |
Coma | 82.85 | 17.68 | 106 | 17331 | 100543 | 79626408 |
Arthralgia | 76.48 | 17.68 | 16 | 17421 | 571787 | 79155164 |
Somnolence | 76.19 | 17.68 | 164 | 17273 | 238817 | 79488134 |
Intentional overdose | 75.52 | 17.68 | 104 | 17333 | 105856 | 79621095 |
Pain | 75.29 | 17.68 | 30 | 17407 | 703772 | 79023179 |
Homicidal ideation | 73.91 | 17.68 | 28 | 17409 | 3429 | 79723522 |
Mania | 70.48 | 17.68 | 46 | 17391 | 18214 | 79708737 |
Affective disorder | 70.35 | 17.68 | 35 | 17402 | 8284 | 79718667 |
Bruxism | 69.77 | 17.68 | 28 | 17409 | 3998 | 79722953 |
Neutrophil count increased | 69.56 | 17.68 | 55 | 17382 | 29341 | 79697610 |
Parkinsonism | 69.50 | 17.68 | 44 | 17393 | 16540 | 79710411 |
Pneumonia aspiration | 68.92 | 17.68 | 79 | 17358 | 66888 | 79660063 |
Drug interaction | 66.00 | 17.68 | 220 | 17217 | 414963 | 79311988 |
Completed suicide | 65.37 | 17.68 | 157 | 17280 | 245610 | 79481341 |
Blood creatine phosphokinase increased | 64.72 | 17.68 | 76 | 17361 | 66014 | 79660937 |
Poisoning deliberate | 64.40 | 17.68 | 44 | 17393 | 18784 | 79708167 |
Dyskinesia | 62.31 | 17.68 | 62 | 17375 | 44711 | 79682240 |
Dyspnoea | 61.86 | 17.68 | 58 | 17379 | 856967 | 78869984 |
Rhinalgia | 61.02 | 17.68 | 22 | 17415 | 2345 | 79724606 |
Priapism | 60.11 | 17.68 | 26 | 17411 | 4479 | 79722472 |
Seizure | 58.33 | 17.68 | 128 | 17309 | 188706 | 79538245 |
Dystonia | 57.10 | 17.68 | 43 | 17394 | 21356 | 79705595 |
Pain in extremity | 55.84 | 17.68 | 7 | 17430 | 364531 | 79362420 |
Lymphocyte count abnormal | 54.39 | 17.68 | 18 | 17419 | 1485 | 79725466 |
Tachycardia | 50.97 | 17.68 | 117 | 17320 | 177651 | 79549300 |
Choreoathetosis | 49.69 | 17.68 | 17 | 17420 | 1553 | 79725398 |
Altered state of consciousness | 49.01 | 17.68 | 54 | 17383 | 43768 | 79683183 |
Muscle rigidity | 48.76 | 17.68 | 38 | 17399 | 19844 | 79707107 |
Joint swelling | 48.18 | 17.68 | 4 | 17433 | 288642 | 79438309 |
Myocarditis | 47.88 | 17.68 | 39 | 17398 | 21694 | 79705257 |
Delusion | 47.86 | 17.68 | 38 | 17399 | 20385 | 79706566 |
Respiratory depression | 45.52 | 17.68 | 42 | 17395 | 27588 | 79699363 |
Hyperkinesia | 43.93 | 17.68 | 18 | 17419 | 2711 | 79724240 |
Trismus | 43.28 | 17.68 | 22 | 17415 | 5445 | 79721506 |
Mutism | 42.85 | 17.68 | 17 | 17420 | 2355 | 79724596 |
Depressed level of consciousness | 41.21 | 17.68 | 75 | 17362 | 96577 | 79630374 |
Suicidal ideation | 38.77 | 17.68 | 64 | 17373 | 76276 | 79650675 |
Delirium | 37.78 | 17.68 | 67 | 17370 | 84560 | 79642391 |
Treatment noncompliance | 36.75 | 17.68 | 51 | 17386 | 52217 | 79674734 |
Neutropenia | 36.69 | 17.68 | 142 | 17295 | 287568 | 79439383 |
Infusion related reaction | 36.28 | 17.68 | 4 | 17433 | 230233 | 79496718 |
Lymphocyte count decreased | 36.07 | 17.68 | 48 | 17389 | 47241 | 79679710 |
Antipsychotic drug level increased | 35.94 | 17.68 | 20 | 17417 | 5937 | 79721014 |
Hallucinations, mixed | 35.82 | 17.68 | 21 | 17416 | 6878 | 79720073 |
Mental disorder | 35.74 | 17.68 | 39 | 17398 | 31263 | 79695688 |
Hypersensitivity | 35.69 | 17.68 | 7 | 17430 | 262232 | 79464719 |
Antisocial personality disorder | 35.51 | 17.68 | 7 | 17430 | 67 | 79726884 |
Affect lability | 35.43 | 17.68 | 25 | 17412 | 11234 | 79715717 |
Psychomotor retardation | 35.24 | 17.68 | 20 | 17417 | 6164 | 79720787 |
Torsade de pointes | 35.04 | 17.68 | 31 | 17406 | 19281 | 79707670 |
Irritability | 34.88 | 17.68 | 44 | 17393 | 41100 | 79685851 |
Leukopenia | 33.72 | 17.68 | 77 | 17360 | 116436 | 79610515 |
Grandiosity | 33.69 | 17.68 | 10 | 17427 | 577 | 79726374 |
Peripheral swelling | 33.11 | 17.68 | 9 | 17428 | 269608 | 79457343 |
Mood altered | 33.09 | 17.68 | 29 | 17408 | 17818 | 79709133 |
Stereotypy | 32.93 | 17.68 | 11 | 17426 | 934 | 79726017 |
Headache | 32.84 | 17.68 | 58 | 17379 | 653714 | 79073237 |
Schizophrenia | 32.53 | 17.68 | 27 | 17410 | 15413 | 79711538 |
Coordination abnormal | 31.83 | 17.68 | 28 | 17409 | 17284 | 79709667 |
Agranulocytosis | 31.75 | 17.68 | 44 | 17393 | 44986 | 79681965 |
Pruritus | 31.69 | 17.68 | 24 | 17413 | 394624 | 79332327 |
Congenital cerebrovascular anomaly | 31.65 | 17.68 | 5 | 17432 | 10 | 79726941 |
Abdominal discomfort | 31.49 | 17.68 | 8 | 17429 | 250719 | 79476232 |
Swelling | 31.19 | 17.68 | 5 | 17432 | 216706 | 79510245 |
Abnormal behaviour | 30.95 | 17.68 | 39 | 17398 | 36382 | 79690569 |
Drug resistance | 30.90 | 17.68 | 42 | 17395 | 42171 | 79684780 |
Speech disorder | 30.87 | 17.68 | 48 | 17389 | 54397 | 79672554 |
Schizoaffective disorder | 30.62 | 17.68 | 13 | 17424 | 2139 | 79724812 |
Cerebral amyloid angiopathy | 29.34 | 17.68 | 8 | 17429 | 339 | 79726612 |
Hepatic enzyme increased | 29.20 | 17.68 | 3 | 17434 | 182607 | 79544344 |
Confusional state | 29.08 | 17.68 | 142 | 17295 | 317855 | 79409096 |
Floppy iris syndrome | 28.99 | 17.68 | 8 | 17429 | 355 | 79726596 |
Lactate pyruvate ratio increased | 28.68 | 17.68 | 6 | 17431 | 79 | 79726872 |
Drug intolerance | 28.57 | 17.68 | 11 | 17426 | 264108 | 79462843 |
Rhabdomyolysis | 28.57 | 17.68 | 67 | 17370 | 103064 | 79623887 |
SARS-CoV-2 test positive | 27.88 | 17.68 | 22 | 17415 | 11694 | 79715257 |
Back pain | 27.79 | 17.68 | 16 | 17421 | 304164 | 79422787 |
Intentional product misuse | 27.65 | 17.68 | 63 | 17374 | 95102 | 79631849 |
Akathisia | 27.55 | 17.68 | 23 | 17414 | 13236 | 79713715 |
Bradyphrenia | 27.54 | 17.68 | 21 | 17416 | 10619 | 79716332 |
Disorganised speech | 27.53 | 17.68 | 12 | 17425 | 2105 | 79724846 |
Electroconvulsive therapy | 27.31 | 17.68 | 6 | 17431 | 101 | 79726850 |
Hepatocellular injury | 27.03 | 17.68 | 42 | 17395 | 47551 | 79679400 |
Crying | 26.81 | 17.68 | 29 | 17408 | 23014 | 79703937 |
Rash | 26.66 | 17.68 | 54 | 17383 | 578304 | 79148647 |
Epileptic encephalopathy | 26.52 | 17.68 | 8 | 17429 | 488 | 79726463 |
Wrong patient received product | 26.49 | 17.68 | 15 | 17422 | 4603 | 79722348 |
Restlessness | 26.37 | 17.68 | 41 | 17396 | 46451 | 79680500 |
Hyperprolactinaemia | 26.32 | 17.68 | 15 | 17422 | 4661 | 79722290 |
Spasmodic dysphonia | 26.29 | 17.68 | 7 | 17430 | 271 | 79726680 |
Blood folate decreased | 25.97 | 17.68 | 10 | 17427 | 1279 | 79725672 |
Encephalopathy | 25.86 | 17.68 | 50 | 17387 | 67347 | 79659604 |
Cardiac arrest | 25.32 | 17.68 | 89 | 17348 | 172007 | 79554944 |
Behaviour disorder | 24.59 | 17.68 | 16 | 17421 | 6297 | 79720654 |
Blood citric acid increased | 24.41 | 17.68 | 5 | 17432 | 59 | 79726892 |
Cardio-respiratory arrest | 24.28 | 17.68 | 65 | 17372 | 108445 | 79618506 |
Streptococcal infection | 24.12 | 17.68 | 18 | 17419 | 8812 | 79718139 |
Nasal discomfort | 24.10 | 17.68 | 15 | 17422 | 5468 | 79721483 |
Cough | 23.89 | 17.68 | 27 | 17410 | 366762 | 79360189 |
Incorrect dose administered | 23.68 | 17.68 | 52 | 17385 | 76578 | 79650373 |
Acanthosis nigricans | 23.46 | 17.68 | 6 | 17431 | 198 | 79726753 |
Tremor | 23.35 | 17.68 | 86 | 17351 | 169997 | 79556954 |
Hypertension | 23.08 | 17.68 | 23 | 17414 | 330969 | 79395982 |
Long QT syndrome | 22.97 | 17.68 | 15 | 17422 | 5940 | 79721011 |
Hepatic cytolysis | 22.95 | 17.68 | 29 | 17408 | 27122 | 79699829 |
Eosinophilic myocarditis | 22.92 | 17.68 | 9 | 17428 | 1213 | 79725738 |
Drug-induced liver injury | 22.90 | 17.68 | 47 | 17390 | 66070 | 79660881 |
Myoclonus | 22.52 | 17.68 | 29 | 17408 | 27631 | 79699320 |
Nasopharyngitis | 22.28 | 17.68 | 14 | 17423 | 253867 | 79473084 |
Miosis | 22.21 | 17.68 | 22 | 17415 | 15767 | 79711184 |
Onychophagia | 21.71 | 17.68 | 5 | 17432 | 105 | 79726846 |
Abortion | 21.68 | 17.68 | 9 | 17428 | 1401 | 79725550 |
Status epilepticus | 21.57 | 17.68 | 27 | 17410 | 25014 | 79701937 |
Anticholinergic syndrome | 21.45 | 17.68 | 12 | 17425 | 3599 | 79723352 |
Parkinsonian gait | 21.43 | 17.68 | 8 | 17429 | 940 | 79726011 |
Sinusitis | 21.38 | 17.68 | 8 | 17429 | 195493 | 79531458 |
Fatigue | 21.32 | 17.68 | 118 | 17319 | 929609 | 78797342 |
Dysarthria | 21.02 | 17.68 | 46 | 17391 | 67576 | 79659375 |
Hallucination | 20.86 | 17.68 | 53 | 17384 | 85692 | 79641259 |
Portal tract inflammation | 20.84 | 17.68 | 5 | 17432 | 126 | 79726825 |
Drug screen false positive | 20.21 | 17.68 | 8 | 17429 | 1101 | 79725850 |
Withdrawal syndrome | 20.08 | 17.68 | 27 | 17410 | 26827 | 79700124 |
Torticollis | 20.05 | 17.68 | 10 | 17427 | 2377 | 79724574 |
Faecaloma | 19.86 | 17.68 | 18 | 17419 | 11546 | 79715405 |
Illusion | 19.85 | 17.68 | 9 | 17428 | 1732 | 79725219 |
Poisoning | 19.80 | 17.68 | 26 | 17411 | 25246 | 79701705 |
Echolalia | 19.73 | 17.68 | 6 | 17431 | 376 | 79726575 |
Myalgia | 19.63 | 17.68 | 8 | 17429 | 185633 | 79541318 |
Depressed mood | 18.63 | 17.68 | 36 | 17401 | 48444 | 79678507 |
Influenza | 18.62 | 17.68 | 3 | 17434 | 129603 | 79597348 |
Psychiatric symptom | 18.46 | 17.68 | 14 | 17423 | 7021 | 79719930 |
Unmasking of previously unidentified disease | 18.42 | 17.68 | 9 | 17428 | 2048 | 79724903 |
Chest discomfort | 18.12 | 17.68 | 4 | 17433 | 138040 | 79588911 |
Persecutory delusion | 18.05 | 17.68 | 12 | 17425 | 4897 | 79722054 |
Urticaria | 17.99 | 17.68 | 9 | 17428 | 185192 | 79541759 |
Gaze palsy | 17.89 | 17.68 | 10 | 17427 | 2995 | 79723956 |
None
Source | Code | Description |
---|---|---|
ATC | N05AA01 | NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Phenothiazines with aliphatic side-chain |
FDA CS | M0016525 | Phenothiazines |
CHEBI has role | CHEBI:37930 | phenothiazine antipsychotic drugs |
CHEBI has role | CHEBI:48561 | dopaminergic antagonists |
CHEBI has role | CHEBI:50919 | antiemetico |
CHEBI has role | CHEBI:76779 | post-proline endopeptidase inhibitors |
CHEBI has role | CHEBI:149553 | anticoronaviral drug |
MeSH PA | D000932 | Antiemetics |
MeSH PA | D014150 | Antipsychotic Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D015259 | Dopamine Agents |
MeSH PA | D018492 | Dopamine Antagonists |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D014149 | Tranquilizing Agents |
FDA EPC | N0000175746 | Phenothiazine |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Nausea and vomiting | indication | 16932000 | |
Disruptive behavior disorder | indication | 54319003 | |
Schizophrenia | indication | 58214004 | DOID:5419 |
Psychotic disorder | indication | 69322001 | |
Bipolar affective disorder, current episode manic | indication | 191618007 | |
Acute intermittent porphyria | indication | 234422006 | DOID:3890 |
Pre-Op Apprehension | indication | ||
Tetanus Adjunct Treatment | indication | ||
Intractable Hiccups | indication | ||
Alcoholism | contraindication | 7200002 | |
Organophosphate poisoning | contraindication | 8260003 | |
Weight gain finding | contraindication | 8943002 | |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Senile dementia | contraindication | 15662003 | |
Chronic disease of respiratory system | contraindication | 17097001 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Orthostatic hypotension | contraindication | 28651003 | |
Torsades de pointes | contraindication | 31722008 | |
Parkinsonism | contraindication | 32798002 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Chronic heart failure | contraindication | 48447003 | |
Bradycardia | contraindication | 48867003 | |
Extrapyramidal disease | contraindication | 76349003 | |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Leukopenia | contraindication | 84828003 | DOID:615 |
Stupor | contraindication | 89458003 | |
Tardive dyskinesia | contraindication | 102449007 | |
Prolonged QT interval | contraindication | 111975006 | |
Acute disease of cardiovascular system | contraindication | 128487001 | |
Angina pectoris | contraindication | 194828000 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Metabolic syndrome X | contraindication | 237602007 | DOID:14221 |
Hyperprolactinemia | contraindication | 237662005 | DOID:12700 |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Coma | contraindication | 371632003 | |
At risk for aspiration | contraindication | 371736008 | |
Visual impairment | contraindication | 397540003 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Obesity | contraindication | 414916001 | DOID:9970 |
Congenital long QT syndrome | contraindication | 442917000 | |
Carcinoma of female breast | contraindication | 447782002 | |
Smokes tobacco daily | contraindication | 449868002 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.04 | Basic |
pKa2 | 2.21 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor | GPCR | ANTAGONIST | Ki | 8.15 | WOMBAT-PK | CHEMBL | |||
D(3) dopamine receptor | GPCR | ANTAGONIST | Ki | 8.54 | WOMBAT-PK | ||||
Mu-type opioid receptor | GPCR | Ki | 5.23 | DRUG MATRIX | |||||
D(1A) dopamine receptor | GPCR | Ki | 7.19 | WOMBAT-PK | |||||
Alpha-2A adrenergic receptor | GPCR | Ki | 6.20 | WOMBAT-PK | |||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.72 | DRUG MATRIX | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.83 | WOMBAT-PK | |||||
Multidrug resistance protein 1 | Transporter | Ki | 6.22 | CHEMBL | |||||
Sodium-dependent serotonin transporter | Transporter | IC50 | 6.92 | CHEMBL | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 7.72 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 6.17 | CHEMBL | |||||
5-hydroxytryptamine receptor 2A | GPCR | ANTAGONIST | Ki | 8.10 | WOMBAT-PK | ||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 7.28 | CHEMBL | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 7.40 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 6 | GPCR | Ki | 7.44 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 7 | GPCR | Ki | 7.41 | WOMBAT-PK | |||||
Alpha-1A adrenergic receptor | GPCR | Ki | 9.55 | PDSP | |||||
D(1B) dopamine receptor | GPCR | Ki | 6.93 | WOMBAT-PK | |||||
Histamine H1 receptor | GPCR | Ki | 8.20 | WOMBAT-PK | |||||
Histamine H2 receptor | GPCR | Ki | 6.76 | PDSP | |||||
Histamine H4 receptor | GPCR | Ki | 6.87 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 7.60 | PDSP | |||||
Muscarinic acetylcholine receptor M2 | GPCR | Ki | 6.75 | PDSP | |||||
Muscarinic acetylcholine receptor M3 | GPCR | Ki | 7.25 | PDSP | |||||
Muscarinic acetylcholine receptor M4 | GPCR | Ki | 7.40 | PDSP | |||||
Muscarinic acetylcholine receptor M5 | GPCR | Ki | 7.38 | PDSP | |||||
Aldehyde oxidase | Enzyme | IC50 | 6.24 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 1B | GPCR | Ki | 5.83 | PDSP | |||||
5-hydroxytryptamine receptor 1D | GPCR | Ki | 6.35 | PDSP | |||||
Alpha-2C adrenergic receptor | GPCR | Ki | 7.10 | WOMBAT-PK | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 5.68 | DRUG MATRIX | |||||
Cytochrome P450 2D6 | Enzyme | Ki | 5.16 | WOMBAT-PK | |||||
D(4) dopamine receptor | GPCR | ANTAGONIST | Ki | 7.69 | WOMBAT-PK | ||||
Alpha-1D adrenergic receptor | GPCR | Ki | 8.71 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 3A | Ion channel | Ki | 6.01 | PDSP | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 9.09 | PDSP | |||||
Kappa-type opioid receptor | GPCR | Ki | 5.35 | DRUG MATRIX | |||||
Calmodulin | Cytosolic other | Kd | 5.91 | CHEMBL | |||||
Delta-type opioid receptor | GPCR | Ki | 5.13 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 5A | GPCR | Ki | 6.93 | PDSP | |||||
5-hydroxytryptamine receptor 1E | GPCR | Ki | 6.46 | PDSP | |||||
Epidermal growth factor receptor | Kinase | IC50 | 4.54 | DRUG MATRIX | |||||
Potassium channel subfamily K member 2 | Ion channel | IC50 | 5.57 | CHEMBL | |||||
Tyrosine-protein kinase Fyn | Kinase | IC50 | 5.06 | DRUG MATRIX | |||||
Receptor tyrosine-protein kinase erbB-2 | Kinase | IC50 | 4.71 | DRUG MATRIX | |||||
Ryanodine receptor 1 | Ion channel | IC50 | 3.57 | WOMBAT-PK | |||||
Major prion protein | Surface antigen | EC50 | 5.70 | CHEMBL | |||||
Solute carrier family 22 member 1 | Transporter | IC50 | 4.57 | CHEMBL | |||||
Substance-K receptor | GPCR | Ki | 5.04 | DRUG MATRIX | |||||
Melanocortin receptor 4 | GPCR | Ki | 4.84 | DRUG MATRIX | |||||
Melanocortin receptor 5 | GPCR | Ki | 5.15 | DRUG MATRIX | |||||
Melanocortin receptor 3 | GPCR | Ki | 4.67 | DRUG MATRIX | |||||
Solute carrier family 22 member 2 | Transporter | IC50 | 4.85 | WOMBAT-PK | |||||
Glutamate [NMDA] receptor | Ion channel | IC50 | 6.22 | CHEMBL | |||||
Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | IC50 | 5.37 | CHEMBL | |||||
FAD-linked sulfhydryl oxidase ALR | Enzyme | AC50 | 5.99 | CHEMBL | |||||
Sphingomyelin phosphodiesterase | Enzyme | IC50 | 4.96 | CHEMBL | |||||
Alpha-2B adrenergic receptor | GPCR | Ki | 7.60 | WOMBAT-PK | |||||
Trypanothione reductase | Enzyme | Ki | 5.49 | CHEMBL | |||||
Arachidonate 15-lipoxygenase | Enzyme | IC50 | 4.80 | DRUG MATRIX | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 8.31 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 1B | GPCR | Ki | 5.74 | DRUG MATRIX | |||||
Membrane-associated progesterone receptor component 1 | Membrane receptor | Ki | 5.78 | DRUG MATRIX | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 8.07 | CHEMBL | |||||
Histamine H1 receptor | GPCR | Ki | 7.30 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | Ki | 8.92 | CHEMBL | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 6.75 | CHEMBL | |||||
5-hydroxytryptamine receptor 7 | GPCR | Ki | 7.68 | CHEMBL | |||||
5-hydroxytryptamine receptor 7 | GPCR | ANTAGONIST | Ki | 5.30 | IUPHAR | ||||
D(1A) dopamine receptor | GPCR | Ki | 7.46 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | IC50 | 7.10 | CHEMBL | |||||
Transient receptor potential cation channel subfamily V member 1 | Ion channel | Ki | 5.89 | CHEMBL | |||||
5-hydroxytryptamine receptor 6 | GPCR | ANTAGONIST | Ki | 8.40 | IUPHAR | ||||
Pleiotropic ABC efflux transporter of multiple drugs | Transporter | IC50 | 5.35 | CHEMBL | |||||
Acetylcholine receptor subunit alpha | Ion channel | IC50 | 5.89 | CHEMBL | |||||
Glutamate NMDA receptor | Ion channel | IC50 | 5.89 | CHEMBL | |||||
Muscarinic acetylcholine receptor | GPCR | Ki | 7.22 | CHEMBL | |||||
Dopamine receptor | GPCR | IC50 | 7.60 | CHEMBL | |||||
Dopamine receptor | GPCR | Ki | 7.85 | CHEMBL | |||||
Serotonin 2 (5-HT2) receptor | GPCR | Ki | 9.15 | CHEMBL | |||||
Adenylate cyclase | Enzyme | Ki | 6.93 | CHEMBL | |||||
Calmodulin | Cytosolic other | IC50 | 5.60 | CHEMBL | |||||
Major prion protein | Unclassified | EC50 | 5.70 | CHEMBL | |||||
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Enzyme | IC50 | 4.64 | CHEMBL |
ID | Source |
---|---|
4017861 | VUID |
N0000146214 | NUI |
D00270 | KEGG_DRUG |
69-09-0 | SECONDARY_CAS_RN |
104728 | RXNORM |
4017860 | VANDF |
4017861 | VANDF |
C0008286 | UMLSCUI |
CHEBI:3647 | CHEBI |
Z80 | PDB_CHEM_ID |
CHEMBL71 | ChEMBL_ID |
CHEMBL1713 | ChEMBL_ID |
DB00477 | DRUGBANK_ID |
D002746 | MESH_DESCRIPTOR_UI |
2726 | PUBCHEM_CID |
83 | IUPHAR_LIGAND_ID |
183 | INN_ID |
U42B7VYA4P | UNII |
2140 | MMSL |
4264 | MMSL |
4428 | MMSL |
4429 | MMSL |
71853 | MMSL |
d00064 | MMSL |
001470 | NDDF |
004587 | NDDF |
387258005 | SNOMEDCT_US |
387479008 | SNOMEDCT_US |
47331002 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
CHLORPROMAZINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9836 | INJECTION | 25 mg | INTRAMUSCULAR | ANDA | 12 sections |
CHLORPROMAZINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9836 | INJECTION | 25 mg | INTRAMUSCULAR | ANDA | 12 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2961 | TABLET, COATED | 10 mg | ORAL | ANDA | 14 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2961 | TABLET, COATED | 10 mg | ORAL | ANDA | 14 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2962 | TABLET, COATED | 25 mg | ORAL | ANDA | 14 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2962 | TABLET, COATED | 25 mg | ORAL | ANDA | 14 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2963 | TABLET, COATED | 50 mg | ORAL | ANDA | 14 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2963 | TABLET, COATED | 50 mg | ORAL | ANDA | 14 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2964 | TABLET, COATED | 100 mg | ORAL | ANDA | 14 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2964 | TABLET, COATED | 100 mg | ORAL | ANDA | 14 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2965 | TABLET, COATED | 200 mg | ORAL | ANDA | 14 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2965 | TABLET, COATED | 200 mg | ORAL | ANDA | 14 sections |
Chlorpromazine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-1397 | INJECTION | 25 mg | INTRAMUSCULAR | ANDA | 17 sections |
Chlorpromazine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-1398 | INJECTION | 25 mg | INTRAMUSCULAR | ANDA | 17 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-4027 | CONCENTRATE | 30 mg | ORAL | ANDA | 17 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-4028 | CONCENTRATE | 100 mg | ORAL | ANDA | 17 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5913 | TABLET, SUGAR COATED | 10 mg | ORAL | ANDA | 17 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5914 | TABLET, SUGAR COATED | 25 mg | ORAL | ANDA | 17 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5915 | TABLET, SUGAR COATED | 50 mg | ORAL | ANDA | 17 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5916 | TABLET, SUGAR COATED | 100 mg | ORAL | ANDA | 17 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5917 | TABLET, SUGAR COATED | 200 mg | ORAL | ANDA | 17 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-0300 | TABLET, SUGAR COATED | 10 mg | ORAL | ANDA | 14 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-0300 | TABLET, SUGAR COATED | 10 mg | ORAL | ANDA | 14 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-0301 | TABLET, SUGAR COATED | 25 mg | ORAL | ANDA | 14 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-0301 | TABLET, SUGAR COATED | 25 mg | ORAL | ANDA | 14 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-0302 | TABLET, SUGAR COATED | 50 mg | ORAL | ANDA | 14 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-0302 | TABLET, SUGAR COATED | 50 mg | ORAL | ANDA | 14 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-0303 | TABLET, SUGAR COATED | 100 mg | ORAL | ANDA | 14 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-0303 | TABLET, SUGAR COATED | 100 mg | ORAL | ANDA | 14 sections |
Chlorpromazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-0304 | TABLET, SUGAR COATED | 200 mg | ORAL | ANDA | 14 sections |