chlorphenamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	616	132-22-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: chlorphenamine chloropheniramine chlorophenylpyridamine chloroprophenpyridamine chlorpheniramine chlorprophenpyridamine chlorpheniramine maleate chlorpheniramine tannate chlorpheniramine polistirex	A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE. Molecular weight: 274.79 Formula: C16H19ClN2 CLOGP: 3.15 LIPINSKI: 0 HAC: 2 HDO: 0 TPSA: 16.13 ALOGS: -3.72 ROTB: 5 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

chlorphenamine
chloropheniramine
chlorophenylpyridamine
chloroprophenpyridamine
chlorpheniramine
chlorprophenpyridamine
chlorpheniramine maleate
chlorpheniramine tannate
chlorpheniramine polistirex

A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.

Molecular weight: 274.79
Formula: C16H19ClN2
CLOGP: 3.15
LIPINSKI: 0
HAC: 2
HDO: 0
TPSA: 16.13
ALOGS: -3.72
ROTB: 5

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
12	mg	O
12	mg	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	10 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.48 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	41 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	3.30 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	2.50 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.70 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	22 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Aug. 15, 1950	FDA	BAYER HEALTHCARE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	164.57	10.31	460	58934	818873	49726857
Contraindicated product administered	152.30	10.31	5	59389	148953	50396777
Synovitis	111.50	10.31	9	59385	123856	50421874
Drug intolerance	110.17	10.31	60	59334	219044	50326686
Sinusitis	103.26	10.31	435	58959	170123	50375607
Dyspnoea	103.13	10.31	1037	58357	546571	49999159
Glossodynia	94.67	10.31	12	59382	115557	50430173
Chest discomfort	89.92	10.31	276	59118	92446	50453284
Maternal exposure during pregnancy	85.91	10.31	40	59354	159738	50385992
Systemic lupus erythematosus	85.77	10.31	29	59365	140593	50405137
Asthma	83.00	10.31	262	59132	89075	50456655
Treatment failure	82.88	10.31	29	59365	137608	50408122
Joint swelling	78.28	10.31	104	59290	245182	50300548
Therapeutic product effect decreased	76.38	10.31	32	59362	136018	50409712
Pericarditis	75.86	10.31	4	59390	78685	50467045
Arthropathy	61.26	10.31	57	59337	157849	50387881
Cough	61.13	10.31	488	58906	240776	50304954
Rheumatoid arthritis	59.53	10.31	91	59303	202459	50343271
Hepatic enzyme increased	58.92	10.31	45	59349	137335	50408395
Completed suicide	58.12	10.31	42	59352	131847	50413883
Wound	57.60	10.31	26	59368	105768	50439962
General physical health deterioration	55.74	10.31	51	59343	142383	50403347
Anaphylactic reaction	53.39	10.31	162	59232	53893	50491837
Neuropathy peripheral	51.06	10.31	237	59157	96520	50449210
Chest pain	49.91	10.31	367	59027	176515	50369215
Rheumatoid factor positive	46.63	10.31	3	59391	49856	50495874
Neutropenic sepsis	45.92	10.31	69	59325	14078	50531652
Discomfort	45.83	10.31	36	59358	108344	50437386
Toxicity to various agents	44.00	10.31	117	59277	212382	50333348
Eosinophilic colitis	43.10	10.31	13	59381	137	50545593
Infective pulmonary exacerbation of cystic fibrosis	41.82	10.31	49	59345	7860	50537870
Anxiety	41.58	10.31	353	59041	177253	50368477
Diarrhoea	41.55	10.31	942	58452	587534	49958196
Helicobacter infection	41.07	10.31	5	59389	49697	50496033
Flushing	39.75	10.31	170	59224	66845	50478885
Excessive eye blinking	36.07	10.31	19	59375	927	50544803
Drug interaction	34.79	10.31	119	59275	199502	50346228
Upper respiratory tract infection	34.44	10.31	161	59233	65737	50479993
Headache	33.89	10.31	805	58589	505730	50040000
Ejection fraction decreased	32.46	10.31	69	59325	18451	50527279
Swelling face	31.63	10.31	134	59260	52461	50493269
Pneumonia	31.57	10.31	621	58773	377780	50167950
Rhinitis allergic	30.65	10.31	40	59354	7160	50538570
Wheezing	30.54	10.31	149	59245	61898	50483832
Product quality issue	30.01	10.31	92	59302	30766	50514964
Back pain	29.58	10.31	391	59003	219639	50326091
Bronchitis	29.27	10.31	216	59178	103943	50441787
Pulmonary embolism	29.21	10.31	212	59182	101492	50444238
Palpitations	28.89	10.31	200	59194	94306	50451424
Sinusitis fungal	27.87	10.31	18	59376	1288	50544442
Dilatation intrahepatic duct acquired	27.60	10.31	14	59380	631	50545099
Product use issue	27.48	10.31	87	59307	149388	50396342
Nasal congestion	26.78	10.31	125	59269	50995	50494735
Dizziness	26.74	10.31	562	58832	345807	50199923
Deep vein thrombosis	26.60	10.31	162	59232	73142	50472588
Emotional distress	26.53	10.31	84	59310	28579	50517151
Chronic sinusitis	25.94	10.31	34	59360	6111	50539619
Folliculitis	25.87	10.31	7	59387	39218	50506512
Bronchospasm	25.64	10.31	55	59339	14799	50530931
Musculoskeletal stiffness	25.62	10.31	72	59322	128409	50417321
Swelling	25.58	10.31	135	59259	200737	50344993
Chronic obstructive pulmonary disease	25.36	10.31	127	59267	53308	50492422
Gastrooesophageal reflux disease	25.31	10.31	165	59229	76263	50469467
Abdominal discomfort	25.07	10.31	164	59230	231477	50314253
Nausea	25.03	10.31	1038	58356	704360	49841370
Sleep apnoea syndrome	24.95	10.31	73	59321	23795	50521935
Sputum increased	24.23	10.31	19	59375	1848	50543882
Salpingo-oophorectomy unilateral	23.91	10.31	12	59382	529	50545201
Anosmia	23.57	10.31	26	59368	3905	50541825
Lip swelling	23.36	10.31	73	59321	24663	50521067
Nail infection	23.24	10.31	19	59375	1962	50543768
Nasal polyps	22.88	10.31	21	59373	2533	50543197
Oropharyngeal pain	22.23	10.31	162	59232	77639	50468091
Off label use	21.82	10.31	409	58985	474017	50071713
Diverticulum	21.51	10.31	42	59352	10572	50535158
Tonsillar hypertrophy	21.15	10.31	13	59381	853	50544877
Injury	20.94	10.31	113	59281	48812	50496918
Gallbladder polyp	20.67	10.31	12	59382	709	50545021
Malignant neoplasm progression	20.57	10.31	30	59364	68094	50477636
Hepatocellular injury	20.51	10.31	3	59391	25944	50519786
Condition aggravated	20.27	10.31	237	59157	296821	50248909
Poor quality device used	20.15	10.31	17	59377	1834	50543896
Foetal exposure during pregnancy	19.79	10.31	4	59390	27355	50518375
Swollen tongue	19.64	10.31	76	59318	28554	50517176
Abdominal pain	19.42	10.31	387	59007	235841	50309889
Rhinorrhoea	19.35	10.31	115	59279	51468	50494262
Coma	19.27	10.31	23	59371	56856	50488874
Throat tightness	19.20	10.31	61	59333	20786	50524944
Candida infection	19.14	10.31	66	59328	23457	50522273
Chemical burns of eye	19.11	10.31	6	59388	73	50545657
Muscle spasms	18.93	10.31	228	59166	125325	50420405
Impaired healing	18.93	10.31	33	59361	69753	50475977
Sinus disorder	18.86	10.31	56	59338	18402	50527328
Biliary sepsis	18.85	10.31	12	59382	838	50544892
Arthralgia	18.41	10.31	384	59010	438318	50107412
Victim of chemical submission	18.35	10.31	8	59386	255	50545475
Infusion site erythema	18.26	10.31	35	59359	8692	50537038
Urinary tract infection	18.07	10.31	366	59028	223654	50322076
Red blood cell sedimentation rate increased	18.03	10.31	6	59388	29410	50516320
Therapeutic product effect incomplete	17.71	10.31	52	59342	91463	50454267
Constipation	17.59	10.31	311	59083	185397	50360333
Acute kidney injury	17.53	10.31	177	59217	227881	50317849
Migraine	17.25	10.31	149	59245	75131	50470599
Acute sinusitis	17.09	10.31	21	59373	3539	50542191
Urticaria	16.87	10.31	229	59165	129332	50416398
Hypoxia	16.69	10.31	110	59284	51013	50494717
Diffuse large B-cell lymphoma refractory	16.59	10.31	12	59382	1034	50544696
Infusion site nodule	15.79	10.31	12	59382	1115	50544615
Mobility decreased	15.79	10.31	45	59349	79903	50465827
Hyperkalaemia	15.70	10.31	20	59374	48069	50497661
Erythema	15.62	10.31	250	59144	146164	50399566
Nasal discomfort	15.55	10.31	21	59373	3883	50541847
Administration site extravasation	15.54	10.31	10	59384	711	50545019
Ear infection	15.48	10.31	66	59328	25904	50519826
Drug reaction with eosinophilia and systemic symptoms	15.44	10.31	7	59387	28417	50517313
Pain in jaw	15.27	10.31	87	59307	38341	50507389
Retinal detachment	15.22	10.31	24	59370	5105	50540625
Death	15.08	10.31	280	59114	325099	50220631
Acute respiratory failure	14.79	10.31	70	59324	28712	50517018
Laryngospasm	14.79	10.31	17	59377	2671	50543059
Cholecystitis chronic	14.66	10.31	34	59360	9635	50536095
Panic attack	14.65	10.31	53	59341	19289	50526441
Exposure during pregnancy	14.47	10.31	83	59311	120932	50424798
Acute interstitial pneumonitis	14.32	10.31	9	59385	614	50545116
Genital ulceration	14.22	10.31	8	59386	445	50545285
Premature delivery	14.20	10.31	5	59389	23658	50522072
Sopor	14.18	10.31	3	59391	19876	50525854
Blister	14.14	10.31	52	59342	85366	50460364
Prosopagnosia	14.14	10.31	4	59390	33	50545697
Agranulocytosis	13.79	10.31	4	59390	21417	50524313
Haemodialysis complication	13.60	10.31	6	59388	197	50545533
Blood creatinine increased	13.52	10.31	45	59349	76115	50469615
Mucosal inflammation	13.49	10.31	87	59307	40055	50505675
C-reactive protein increased	13.43	10.31	37	59357	66437	50479293
Delirium	13.41	10.31	15	59379	38177	50507553
Depression	13.24	10.31	270	59124	165153	50380577
Vulvovaginal candidiasis	13.12	10.31	16	59378	2676	50543054
Multiple allergies	13.10	10.31	30	59364	8433	50537297
Product dose omission issue	13.09	10.31	295	59099	183543	50362187
Eosinophilic myocarditis	12.98	10.31	7	59387	358	50545372
Hereditary angioedema	12.86	10.31	23	59371	5419	50540311
Ventricular extrasystoles	12.80	10.31	34	59360	10482	50535248
Feeling hot	12.59	10.31	84	59310	39118	50506612
Pain	12.50	10.31	554	58840	578349	49967381
Lacrimation increased	12.39	10.31	46	59348	16946	50528784
Gastroenteritis viral	12.19	10.31	49	59345	18737	50526993
Nail dystrophy	12.17	10.31	9	59385	802	50544928
Biliary dyskinesia	12.17	10.31	15	59379	2535	50543195
Pancreatitis chronic	12.15	10.31	14	59380	2206	50543524
Terminal ileitis	12.01	10.31	8	59386	603	50545127
Diastolic dysfunction	12.01	10.31	22	59372	5280	50540450
Renal failure	11.77	10.31	75	59319	106558	50439172
Hip arthroplasty	11.77	10.31	11	59383	30418	50515312
Multiple organ dysfunction syndrome	11.75	10.31	26	59368	50311	50495419
Pyrexia	11.74	10.31	552	58842	379651	50166079
Infusion site swelling	11.73	10.31	26	59368	7150	50538580
Ageusia	11.70	10.31	35	59359	11548	50534182
Irritable bowel syndrome	11.66	10.31	27	59367	51414	50494316
Tongue pruritus	11.65	10.31	7	59387	441	50545289
Product prescribing error	11.64	10.31	5	59389	20956	50524774
Haemoptysis	11.58	10.31	60	59334	25513	50520217
Drug resistance	11.42	10.31	4	59390	18985	50526745
Hiatus hernia	11.23	10.31	47	59347	18297	50527433
Gastrointestinal disorder	11.18	10.31	65	59329	94391	50451339
HER2 positive breast cancer	11.16	10.31	6	59388	305	50545425
Hepatic failure	10.99	10.31	13	59381	32270	50513460
Low turnover osteopathy	10.91	10.31	18	59376	3976	50541754
Dyspnoea at rest	10.73	10.31	17	59377	3630	50542100
Loss of personal independence in daily activities	10.72	10.31	44	59350	70006	50475724
Embolism venous	10.70	10.31	14	59380	2511	50543219
Alopecia	10.69	10.31	213	59181	244834	50300896
Female genital tract fistula	10.66	10.31	17	59377	3649	50542081
Interstitial lung disease	10.44	10.31	30	59364	53146	50492584
Axillary pain	10.42	10.31	11	59383	1573	50544157
Retching	10.39	10.31	36	59358	12826	50532904
Coronary artery disease	10.34	10.31	65	59329	29661	50516069
Gallbladder disorder	10.33	10.31	43	59351	16699	50529031

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sinusitis	63.87	11.23	118	28840	34232	29511337
Lower respiratory tract infection	51.74	11.23	93	28865	26409	29519160
Asthma	42.55	11.23	99	28859	33750	29511819
Painful respiration	41.17	11.23	21	28937	1153	29544416
Upper respiratory tract infection	40.02	11.23	85	28873	27264	29518305
Chest injury	39.96	11.23	22	28936	1411	29544158
Infective pulmonary exacerbation of cystic fibrosis	37.60	11.23	38	28920	6198	29539371
Infusion related reaction	37.39	11.23	111	28847	43775	29501794
Walking aid user	36.64	11.23	21	28937	1456	29544113
General physical health deterioration	34.47	11.23	30	28928	102827	29442742
Dry skin	31.32	11.23	70	28888	23237	29522332
Dyspnoea	31.11	11.23	470	28488	326262	29219307
Drug ineffective	30.77	11.23	219	28739	362951	29182618
Urticaria	30.49	11.23	120	28838	54540	29491029
Bronchitis	30.22	11.23	92	28866	36776	29508793
Cough	28.52	11.23	217	28741	126510	29419059
Flushing	27.27	11.23	76	28882	28916	29516653
Hypoacusis	26.10	11.23	49	28909	14374	29531195
Toxic epidermal necrolysis	26.06	11.23	56	28902	18097	29527472
Feeling cold	25.75	11.23	38	28920	9153	29536416
Failure to anastomose	25.01	11.23	9	28949	206	29545363
Neutropenic sepsis	23.97	11.23	42	28916	11685	29533884
Oropharyngeal blistering	22.66	11.23	8	28950	173	29545396
Hypersomnia	22.61	11.23	39	28919	10715	29534854
Rash	22.01	11.23	283	28675	189536	29356033
Pruritus	21.91	11.23	192	28766	116657	29428912
Lip swelling	21.03	11.23	41	28917	12369	29533200
Personality change	20.50	11.23	24	28934	4614	29540955
Pneumonia	20.26	11.23	432	28526	319740	29225829
Febrile neutropenia	19.80	11.23	182	28776	112058	29433511
Seasonal allergy	18.67	11.23	24	28934	5078	29540491
Nasal congestion	18.26	11.23	50	28908	18829	29526740
Hot flush	18.14	11.23	43	28915	14827	29530742
Oral candidiasis	17.65	11.23	35	28923	10687	29534882
Lactic acidosis	17.62	11.23	4	28954	30243	29515326
Hypoxic-ischaemic encephalopathy	17.02	11.23	21	28937	4263	29541306
Productive cough	16.91	11.23	68	28890	31191	29514378
Cystic fibrosis	16.88	11.23	13	28945	1479	29544090
Chest discomfort	16.71	11.23	89	28869	45894	29499675
Peripheral swelling	16.54	11.23	113	28845	63626	29481943
Off label use	16.50	11.23	202	28756	300598	29244971
Acute kidney injury	16.16	11.23	174	28784	265093	29280476
Malignant neoplasm progression	15.95	11.23	30	28928	73829	29471740
Sputum increased	15.95	11.23	14	28944	1913	29543656
Renal failure	15.91	11.23	61	28897	118538	29427031
HIV associated nephropathy	15.54	11.23	7	28951	291	29545278
Constipation	15.29	11.23	175	28783	113985	29431584
Aortic aneurysm	15.01	11.23	24	28934	6196	29539373
Treatment failure	14.66	11.23	9	28949	36930	29508639
Hypersensitivity	14.45	11.23	95	28863	52808	29492761
Drug hypersensitivity	14.18	11.23	115	28843	68291	29477278
Wheezing	13.94	11.23	67	28891	33173	29512396
Rhinitis allergic	13.78	11.23	15	28943	2665	29542904
Accidental exposure to product by child	13.60	11.23	11	28947	1343	29544226
Lip dry	13.31	11.23	10	28948	1096	29544473
Swelling face	13.27	11.23	47	28911	20303	29525266
Death	13.16	11.23	246	28712	341838	29203731
Drug interaction	13.02	11.23	127	28831	197258	29348311
Rhabdomyolysis	12.87	11.23	25	28933	60783	29484786
Limb mass	12.84	11.23	8	28950	646	29544923
Sputum discoloured	12.76	11.23	23	28935	6540	29539029
Chills	12.75	11.23	116	28842	71184	29474385
Infusion site pain	12.70	11.23	15	28943	2910	29542659
Hyperkalaemia	12.34	11.23	26	28932	61366	29484203
Pyrexia	11.93	11.23	367	28591	287255	29258314
Blood creatinine increased	11.91	11.23	43	28915	85059	29460510
Neutropenic infection	11.84	11.23	10	28948	1297	29544272
Bradycardia foetal	11.54	11.23	6	28952	343	29545226
Fatigue	11.53	11.23	398	28560	316423	29229146
Dyspnoea exertional	11.51	11.23	68	28890	36422	29509147
Therapeutic product effect incomplete	11.39	11.23	13	28945	39292	29506277

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	141.67	9.94	468	70850	839779	63587635
Dyspnoea	115.60	9.94	1257	70061	717417	63709997
Contraindicated product administered	98.46	9.94	5	71313	107824	64319590
Chest discomfort	91.02	9.94	309	71009	115797	64311617
Synovitis	78.14	9.94	9	71309	99081	64328333
General physical health deterioration	75.34	9.94	69	71249	204356	64223058
Asthma	75.12	9.94	254	71064	94971	64332443
Infective pulmonary exacerbation of cystic fibrosis	74.57	9.94	78	71240	11718	64415696
Cough	69.53	9.94	571	70747	301577	64125837
Neutropenic sepsis	65.63	9.94	103	71215	23169	64404245
Drug intolerance	64.02	9.94	68	71250	187924	64239490
Flushing	59.58	9.94	207	71111	78441	64348973
Treatment failure	58.43	9.94	28	71290	116788	64310626
Joint swelling	53.27	9.94	98	71220	215284	64212130
Drug interaction	52.56	9.94	214	71104	361869	64065545
Pemphigus	51.87	9.94	4	71314	60697	64366717
Sinusitis	50.06	9.94	304	71014	145624	64281790
Pericarditis	48.49	9.94	6	71312	62510	64364904
Anaphylactic reaction	47.97	9.94	176	71142	68488	64358926
Upper respiratory tract infection	45.44	9.94	180	71138	72605	64354809
Chest pain	45.43	9.94	429	70889	235551	64191863
Swelling face	45.04	9.94	156	71162	59010	64368404
Acute kidney injury	43.73	9.94	304	71014	448936	63978478
Lip swelling	42.67	9.94	103	71215	31804	64395610
Anxiety	42.34	9.94	375	70943	202274	64225140
Neuropathy peripheral	41.04	9.94	246	71072	117279	64310135
Rheumatoid arthritis	40.39	9.94	75	71243	164219	64263195
Pneumonia	39.04	9.94	850	70468	558726	63868688
Therapeutic product effect decreased	38.94	9.94	42	71276	115309	64312105
Sputum increased	38.41	9.94	32	71286	3603	64423811
Completed suicide	38.23	9.94	124	71194	224290	64203124
Maternal exposure during pregnancy	38.19	9.94	30	71288	95854	64331560
Pulmonary embolism	37.10	9.94	283	71035	146073	64281341
Systemic lupus erythematosus	36.72	9.94	20	71298	77592	64349822
Wheezing	35.03	9.94	179	71139	80400	64347014
Palpitations	34.76	9.94	216	71102	104272	64323142
Product quality issue	32.41	9.94	89	71229	29710	64397704
Constipation	32.03	9.94	391	70927	228946	64198468
Rhinitis allergic	31.96	9.94	42	71276	8036	64419378
Helicobacter infection	31.48	9.94	3	71315	38359	64389055
Urticaria	31.47	9.94	274	71044	147043	64280371
Nasal congestion	31.36	9.94	140	71178	59518	64367896
Eosinophilic colitis	31.30	9.94	13	71305	390	64427024
Hyperkalaemia	30.74	9.94	40	71278	101089	64326325
Gastrooesophageal reflux disease	30.28	9.94	176	71142	82967	64344447
Malignant neoplasm progression	30.03	9.94	49	71269	112822	64314592
Renal failure	29.83	9.94	102	71216	181586	64245828
Hepatic enzyme increased	29.62	9.94	62	71256	129881	64297533
Excessive eye blinking	29.45	9.94	18	71300	1242	64426172
Chest injury	29.05	9.94	23	71295	2410	64425004
Glossodynia	28.72	9.94	18	71300	64678	64362736
Off label use	28.68	9.94	510	70808	632296	63795118
Back pain	28.48	9.94	411	70907	249760	64177654
Rheumatoid factor positive	27.97	9.94	3	71315	34935	64392479
Bronchospasm	27.93	9.94	69	71249	21613	64405801
Sleep apnoea syndrome	27.52	9.94	84	71234	29748	64397666
Lower respiratory tract infection	26.86	9.94	188	71130	94426	64332988
Deep vein thrombosis	26.43	9.94	203	71115	104979	64322435
Febrile neutropenia	25.78	9.94	319	70999	187338	64240076
Drug resistance	25.73	9.94	4	71314	35098	64392316
Arthropathy	25.69	9.94	60	71258	120907	64306507
Plethoric face	25.63	9.94	6	71312	22	64427392
Salpingo-oophorectomy unilateral	25.58	9.94	12	71306	484	64426930
Blood creatinine increased	25.27	9.94	72	71246	135710	64291704
Headache	25.04	9.94	764	70554	528703	63898711
Lactic acidosis	24.72	9.94	19	71299	61391	64366023
Dilatation intrahepatic duct acquired	24.56	9.94	13	71305	681	64426733
Sinusitis fungal	24.49	9.94	18	71300	1688	64425726
Lacrimation increased	24.29	9.94	59	71259	18287	64409127
Emotional distress	24.01	9.94	91	71227	35947	64391467
Interstitial lung disease	23.67	9.94	45	71273	97687	64329727
Sopor	22.63	9.94	3	71315	29658	64397756
Bronchitis	22.56	9.94	201	71117	108542	64318872
Diarrhoea	22.31	9.94	994	70324	721710	63705704
Therapeutic product effect incomplete	22.24	9.94	51	71267	103431	64323983
Hypoxia	22.07	9.94	170	71148	87979	64339435
Oropharyngeal pain	22.04	9.94	171	71147	88696	64338718
C-reactive protein increased	21.87	9.94	45	71273	94864	64332550
Dizziness	21.75	9.94	626	70692	429537	63997877
Dry skin	21.09	9.94	112	71206	51049	64376365
Painful respiration	20.60	9.94	21	71297	3060	64424354
Migraine	20.48	9.94	129	71189	62548	64364866
Ejection fraction decreased	20.39	9.94	74	71244	28633	64398781
Multiple organ dysfunction syndrome	20.20	9.94	52	71266	101361	64326053
Pyrexia	20.09	9.94	781	70537	557863	63869551
Injury	20.04	9.94	118	71200	55874	64371540
Coma	19.80	9.94	42	71276	87573	64339841
Failure to anastomose	19.64	9.94	8	71310	228	64427186
Hypersomnia	19.59	9.94	57	71261	19660	64407754
Tachycardia	19.56	9.94	252	71066	149327	64278087
Nasal polyps	19.45	9.94	22	71296	3607	64423807
Chronic sinusitis	19.36	9.94	29	71289	6263	64421151
Musculoskeletal stiffness	18.99	9.94	71	71247	123135	64304279
Nail infection	18.98	9.94	16	71302	1831	64425583
Hepatic failure	18.88	9.94	20	71298	55374	64372040
Erythema	18.82	9.94	301	71017	186769	64240645
Nausea	18.70	9.94	1054	70264	784746	63642668
Acute sinusitis	18.59	9.94	23	71295	4143	64423271
Throat tightness	18.44	9.94	62	71256	23098	64404316
Delirium	18.44	9.94	30	71288	69164	64358250
Oral candidiasis	18.36	9.94	62	71256	23150	64404264
Chronic obstructive pulmonary disease	18.33	9.94	138	71180	70910	64356504
Hot flush	18.23	9.94	100	71218	46135	64381279
Nasal discomfort	17.90	9.94	23	71295	4305	64423109
Poor quality device used	17.83	9.94	16	71302	1991	64425423
Victim of chemical submission	17.80	9.94	8	71310	292	64427122
Gastroenteritis viral	17.68	9.94	55	71263	19674	64407740
Feeling cold	17.64	9.94	62	71256	23616	64403798
Chemical burns of eye	17.57	9.94	6	71312	103	64427311
Rhabdomyolysis	17.54	9.94	48	71270	91678	64335736
Toxicity to various agents	17.37	9.94	290	71028	363223	64064191
Urinary tract infection	17.10	9.94	355	70963	231241	64196173
Cystic fibrosis	17.03	9.94	20	71298	3414	64424000
Pruritus	17.00	9.94	459	70859	311941	64115473
Rhinorrhoea	16.92	9.94	119	71199	59850	64367564
Sinus headache	16.84	9.94	22	71296	4185	64423229
Myelosuppression	16.84	9.94	3	71315	23827	64403587
Product prescribing error	16.81	9.94	9	71309	35260	64392154
Rash macular	16.78	9.94	61	71257	23624	64403790
Fatigue	16.59	9.94	998	70320	747732	63679682
Discomfort	16.47	9.94	41	71277	80837	64346577
Renal impairment	16.45	9.94	85	71233	134932	64292482
Mobility decreased	16.35	9.94	45	71273	85795	64341619
Gallbladder polyp	16.29	9.94	11	71307	901	64426513
Wound	16.18	9.94	38	71280	76439	64350975
Sinus disorder	15.96	9.94	48	71270	16860	64410554
Female genital tract fistula	15.78	9.94	17	71301	2641	64424773
Folliculitis	15.35	9.94	7	71311	30070	64397344
Laryngospasm	15.34	9.94	19	71299	3426	64423988
Condition aggravated	15.31	9.94	305	71013	372121	64055293
Blood pressure fluctuation	15.27	9.94	21	71297	51850	64375564
Vulvovaginal candidiasis	15.13	9.94	15	71303	2115	64425299
Paraesthesia oral	15.06	9.94	40	71278	13091	64414323
Tonsillar hypertrophy	14.90	9.94	12	71306	1289	64426125
Panic attack	14.87	9.94	54	71264	20899	64406515
Insomnia	14.85	9.94	304	71014	197532	64229882
Infusion site erythema	14.83	9.94	27	71291	6846	64420568
Rash	14.83	9.94	634	70684	457915	63969499
Lupus vulgaris	14.79	9.94	5	71313	83	64427331
Pancreatitis chronic	14.74	9.94	19	71299	3567	64423847
HIV associated nephropathy	14.66	9.94	7	71311	294	64427120
Hiatus hernia	14.65	9.94	52	71266	19905	64407509
Bicuspid aortic valve	14.59	9.94	4	71314	31	64427383
Hypoacusis	14.58	9.94	62	71256	25805	64401609
Tubulointerstitial nephritis	14.57	9.94	8	71310	30901	64396513
Genital ulceration	14.56	9.94	9	71309	634	64426780
Impaired healing	14.50	9.94	28	71290	60445	64366969
Prosopagnosia	14.48	9.94	4	71314	32	64427382
Death	14.41	9.94	415	70903	482290	63945124
Feeling hot	14.31	9.94	93	71225	45570	64381844
Oxygen saturation decreased	14.19	9.94	181	71137	106995	64320419
Bradycardia	14.07	9.94	75	71243	118144	64309270
Cellulitis	14.07	9.94	162	71156	93495	64333919
Biliary sepsis	13.92	9.94	12	71306	1416	64425998
Haemorrhoids	13.89	9.94	58	71260	23943	64403471
Pancytopenia	13.88	9.94	97	71221	143212	64284202
Biliary dyskinesia	13.78	9.94	15	71303	2357	64425057
Pulmonary fibrosis	13.70	9.94	8	71310	29870	64397544
Hyperpyrexia	13.66	9.94	22	71296	5055	64422359
Cholecystitis chronic	13.52	9.94	31	71287	9256	64418158
Pain in jaw	13.38	9.94	84	71234	40671	64386743
Swollen tongue	13.38	9.94	75	71243	34879	64392535
Exposure to toxic agent	13.04	9.94	24	71294	6135	64421279
Productive cough	13.03	9.94	131	71187	73072	64354342
Suffocation feeling	12.91	9.94	12	71306	1562	64425852
Walking aid user	12.71	9.94	24	71294	6257	64421157
Extrapyramidal disorder	12.70	9.94	3	71315	19549	64407865
Nail dystrophy	12.63	9.94	9	71309	804	64426610
Administration site extravasation	12.62	9.94	10	71308	1049	64426365
Depression	12.57	9.94	278	71040	183013	64244401
Toxic skin eruption	12.44	9.94	3	71315	19281	64408133
Neutropenia	12.44	9.94	350	70968	239274	64188140
Candida infection	12.42	9.94	68	71250	31351	64396063
Gastrointestinal disorder	12.37	9.94	54	71264	89655	64337759
HER2 positive breast cancer	12.37	9.94	6	71312	261	64427153
Tympanic membrane hyperaemia	12.24	9.94	3	71315	14	64427400
Dyspnoea exertional	12.20	9.94	130	71188	73600	64353814
Sinus operation	12.16	9.94	12	71306	1683	64425731
Red blood cell sedimentation rate increased	12.15	9.94	10	71308	31225	64396189
Muscle spasms	12.03	9.94	221	71097	140802	64286612
Product use issue	11.78	9.94	109	71209	151606	64275808
Loss of personal independence in daily activities	11.66	9.94	41	71277	72413	64355001
Eosinophilia	11.63	9.94	15	71303	38061	64389353
Haemodialysis complication	11.61	9.94	6	71312	299	64427115
Failure of child resistant product closure	11.59	9.94	4	71314	71	64427343
Accidental exposure to product by child	11.55	9.94	14	71304	2471	64424943
Altered state of consciousness	11.50	9.94	15	71303	37887	64389527
Tongue pruritus	11.48	9.94	7	71311	481	64426933
Oropharyngeal blistering	11.48	9.94	8	71310	690	64426724
Septic shock	11.41	9.94	69	71249	105368	64322046
Otitis media	11.35	9.94	21	71297	5392	64422022
Product complaint	11.34	9.94	34	71284	11920	64415494
Retinal detachment	10.93	9.94	26	71292	7950	64419464
Seasonal allergy	10.80	9.94	33	71285	11693	64415721
Mood swings	10.73	9.94	43	71275	17425	64409989
Agranulocytosis	10.73	9.94	16	71302	38213	64389201
Neutropenic infection	10.68	9.94	12	71306	1953	64425461
Toxic epidermal necrolysis	10.63	9.94	74	71244	37092	64390322
Onychalgia	10.53	9.94	8	71310	789	64426625
Vision blurred	10.50	9.94	149	71169	90167	64337247
Bronchopulmonary aspergillosis	10.45	9.94	4	71314	19081	64408333
Intentional self-injury	10.45	9.94	10	71308	29034	64398380
Vomiting	10.43	9.94	725	70593	550392	63877022
Hyperhidrosis	10.39	9.94	195	71123	124725	64302689
Anosmia	10.37	9.94	18	71300	4399	64423015
Vulvovaginal pain	10.20	9.94	11	71307	1711	64425703
Eye pruritus	10.18	9.94	34	71284	12625	64414789
Cyanosis	10.18	9.94	50	71268	22105	64405309
Product dose omission issue	9.97	9.94	284	71034	194463	64232951
Dyspepsia	9.95	9.94	134	71184	80178	64347236

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R06AB04	RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Substituted alkylamines
ATC	R06AB54	RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Substituted alkylamines
FDA MoA	N0000000190	Histamine H1 Receptor Antagonists
FDA EPC	N0000175587	Histamine-1 Receptor Antagonist
MeSH PA	D018926	Anti-Allergic Agents
MeSH PA	D000982	Antipruritics
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D018494	Histamine Agents
MeSH PA	D006633	Histamine Antagonists
MeSH PA	D006634	Histamine H1 Antagonists
MeSH PA	D018377	Neurotransmitter Agents
CHEBI has role	CHEBI:35469	antidepressants
CHEBI has role	CHEBI:37955	H1 receptor antagonists
CHEBI has role	CHEBI:37956	antihistamines
CHEBI has role	CHEBI:50857	anti-allergic drugs
CHEBI has role	CHEBI:50949	SSRI
CHEBI has role	CHEBI:59683	antipruritic drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Dermatographic urticaria	indication	7632005	DOID:743
Vasomotor rhinitis	indication	8229003	DOID:4730
Allergic rhinitis	indication	61582004
Nasal discharge	indication	64531003
Nasal congestion	indication	68235000
Sneezing	indication	76067001
Common cold	indication	82272006	DOID:10459
Urticaria	indication	126485001
Influenza-like symptoms	indication	315642008
Seasonal allergic rhinitis	indication	367498001
Itching of skin	indication	418363000
Allergic conjunctivitis	indication	473460002	DOID:11204
Brain damage	contraindication	2470005
Necrotizing enterocolitis in fetus OR newborn	contraindication	2707005
Goiter	contraindication	3716002	DOID:12176
Ocular hypertension	contraindication	4210003	DOID:9282
Gastritis	contraindication	4556007	DOID:4029
Tachyarrhythmia	contraindication	6285003
Suicidal thoughts	contraindication	6471006
Dependent drug abuse	contraindication	6525002
Urinary tract obstruction	contraindication	7163005	DOID:5200
Alcoholism	contraindication	7200002
Alcohol withdrawal delirium	contraindication	8635005
Peptic ulcer	contraindication	13200003	DOID:750
Chronic obstructive lung disease	contraindication	13645005	DOID:3083
Asthenia	contraindication	13791008
Hyperkalemia	contraindication	14140009
Severe chronic ulcerative colitis	contraindication	14311001
Constipation	contraindication	14760008	DOID:2089
Disorder of autonomic nervous system	contraindication	15241006
Chronic disease of respiratory system	contraindication	17097001
Mood swings	contraindication	18963009
Hashimoto thyroiditis	contraindication	21983002
Myocardial infarction	contraindication	22298006	DOID:5844
Glaucoma	contraindication	23986001	DOID:1686
Inflammatory bowel disease	contraindication	24526004	DOID:0050589
Ventricular tachycardia	contraindication	25569003
Acute tuberculosis	contraindication	25629007
Alcohol intoxication	contraindication	25702006
Shock	contraindication	27942005
Toxic megacolon	contraindication	28536002	DOID:1770
Atony of colon	contraindication	29479008
Hypercapnia	contraindication	29596007
Bronchitis	contraindication	32398004	DOID:6132
Dehydration	contraindication	34095006
Hyperthyroidism	contraindication	34486009	DOID:7998
Acute hepatitis	contraindication	37871000
Hypertensive disorder	contraindication	38341003	DOID:10763
Hypovolemic shock	contraindication	39419009
Disorder of gallbladder	contraindication	39621005	DOID:0060262
Gastrointestinal ulcer	contraindication	40845000
Hypothyroidism	contraindication	40930008	DOID:1459
Complete trisomy 21 syndrome	contraindication	41040004	DOID:14250
Body fluid retention	contraindication	43498006
Conduction disorder of the heart	contraindication	44808001
Low blood pressure	contraindication	45007003
Achalasia of esophagus	contraindication	45564002	DOID:9164
Chronic heart failure	contraindication	48447003
Bradycardia	contraindication	48867003
Disorder of cardiovascular system	contraindication	49601007	DOID:1287
Acidosis	contraindication	51387008
Gastrointestinal perforation	contraindication	51875005
Vitamin K deficiency	contraindication	52675005	DOID:11249
Nasal polyp	contraindication	52756005
Coronary arteriosclerosis	contraindication	53741008	DOID:3393
Paralytic ileus	contraindication	55525008	DOID:8442
Peptic reflux disease	contraindication	57643001
Acute nephropathy	contraindication	58574008
Hepatic failure	contraindication	59927004
Ulcerative colitis	contraindication	64766004	DOID:8577
Blood coagulation disorder	contraindication	64779008	DOID:1247
Arterial thrombosis	contraindication	65198009
Drug AND/OR toxin-induced diarrhea	contraindication	65979008
Substance abuse	contraindication	66214007
Benign intracranial hypertension	contraindication	68267002	DOID:11459
Psychotic disorder	contraindication	69322001
Poisoning by acetaminophen	contraindication	70273001
Agoraphobia	contraindication	70691001	DOID:593
Arteriosclerotic vascular disease	contraindication	72092001
Diabetes mellitus	contraindication	73211009	DOID:9351
Factor II deficiency	contraindication	73975000
Reye's syndrome	contraindication	74351001	DOID:14525
Gastrointestinal hemorrhage	contraindication	74474003
Urethral stricture	contraindication	76618002
Thrombotic thrombocytopenic purpura	contraindication	78129009	DOID:10772
Spastic paralysis	contraindication	78403003
Disturbance of salivary secretion	contraindication	78948009
Decreased respiratory function	contraindication	80954004
Injury of head	contraindication	82271004
Chronic idiopathic constipation	contraindication	82934008
Cor pulmonale	contraindication	83291003	DOID:8515
Hiatal hernia	contraindication	84089009	DOID:12642
Epilepsy	contraindication	84757009	DOID:1826
Pulmonary emphysema	contraindication	87433001
Gout	contraindication	90560007	DOID:13189
Kidney disease	contraindication	90708001	DOID:557
Thyrotoxicosis	contraindication	90739004	DOID:7997
Hemophilia	contraindication	90935002
Myasthenia gravis	contraindication	91637004	DOID:437
Dermatitis herpetiformis	contraindication	111196000	DOID:8505
Anemia due to enzyme deficiency	contraindication	111577008
Acute abdominal pain	contraindication	116290004
Procedure on urinary system	contraindication	118677009
Gastrointestinal obstruction	contraindication	126765001
Neoplasm of brain	contraindication	126952004	DOID:1319
von Willebrand disorder	contraindication	128105004	DOID:12531
Seizure disorder	contraindication	128613002
Autonomic dysreflexia	contraindication	129618003
Bleeding	contraindication	131148009
Drug-induced psychosis	contraindication	191483003	DOID:1742
Obsessive-compulsive disorder	contraindication	191736004	DOID:10933
Insomnia	contraindication	193462001
Partial atrioventricular block	contraindication	195039008
Acute pancreatitis	contraindication	197456007	DOID:2913
Impaired renal function disorder	contraindication	197663003
Coronary artery bypass graft	contraindication	232717009
Myocardial dysfunction	contraindication	233928007
Gastroesophageal reflux disease	contraindication	235595009	DOID:8534
Disease of liver	contraindication	235856003	DOID:409
Bladder outflow obstruction	contraindication	236645006
Morbid obesity	contraindication	238136002	DOID:11981
Hypocomplementemic urticarial vasculitis	contraindication	239945009
Pyloric obstruction	contraindication	244815007
Benign prostatic hyperplasia	contraindication	266569009
Retention of urine	contraindication	267064002
Anemia	contraindication	271737000	DOID:2355
Drowsy	contraindication	271782001
Exacerbation of asthma	contraindication	281239006
Pregnancy, function	contraindication	289908002
Lesion of brain	contraindication	301766008
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Panic disorder	contraindication	371631005	DOID:594
Coma	contraindication	371632003
Primary adrenocortical insufficiency	contraindication	373662000
Operation on gastrointestinal tract	contraindication	386621005
Hypoxia	contraindication	389086002
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Cardiovascular event risk	contraindication	395112001
Pseudomembranous enterocolitis	contraindication	397683000
Gastric ulcer	contraindication	397825006	DOID:10808
Breastfeeding (mother)	contraindication	413712001
Chronic lung disease	contraindication	413839001
Chronic myocardial ischemia	contraindication	413844008	DOID:3393
Disorder of coronary artery	contraindication	414024009
Myocardial ischemia	contraindication	414795007	DOID:3393
Myocardial infarction in recovery phase	contraindication	418044006
Central nervous system depression	contraindication	418072004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant	contraindication	422681000
Fever greater than 100.4 Fahrenheit	contraindication	426000000
Dysfunction of sphincter of Oddi	contraindication	430887001
Hypertensive urgency	contraindication	443482000
Acute erosive gastritis	contraindication	444926003
Smokes tobacco daily	contraindication	449868002
Acute exacerbation of asthma	contraindication	708038006
Acute Thromboembolic Stroke	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.47	Basic
pKa2	4.14	Basic

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
8MG;54.3MG	TUXARIN ER	MAINPOINTE	N206323	June 22, 2015	RX	TABLET, EXTENDED RELEASE	ORAL	9066942	Jan. 3, 2032	TREATMENT OF COUGH AND SYMPTOMS ASSOCIATED WITH UPPER RESPIRATORY ALLERGIES OR A COMMON COLD WITH CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE ORALLY ADMINISTERED EXTENDED RELEASE TABLETS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN	ANTAGONIST	Ki	8.15	WOMBAT-PK	CHEMBL
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Kd	7.82	WOMBAT-PK
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	5.17	PDSP
Histamine H4 receptor	GPCR	Q9H3N8	HRH4_HUMAN		Ki	6.67	WOMBAT-PK
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		Ki	4.97	WOMBAT-PK
Sodium channel alpha subunits; brain (Types I, II, III)	Ion channel	P35498 Q99250 Q9NY46	SCN1A_HUMAN SCN2A_HUMAN SCN3A_HUMAN		IC50	5	CHEMBL
Lethal(3)malignant brain tumor-like protein 1	Unclassified	Q9Y468	LMBL1_HUMAN		IC50	4.39	CHEMBL
Lethal(3)malignant brain tumor-like protein 3	Unclassified	Q96JM7	LMBL3_HUMAN		IC50	4.38	CHEMBL
MBT domain-containing protein 1	Unclassified	Q05BQ5	MBTD1_HUMAN		IC50	4.47	CHEMBL
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Kd	5.84	SCIENTIFIC LITERATURE
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		IC50	5.96	CHEMBL
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN		Kd	5.98	SCIENTIFIC LITERATURE
Histamine H1 receptor	GPCR		HRH1_CAVPO		IC50	8.06	CHEMBL
Histamine H1 receptor	GPCR		HRH1_RAT		Ki	8.70	CHEMBL
Chloroquine resistance transporter	Transporter		CRT_PLAFA		IC50	4.27	CHEMBL

External reference:

ID	Source
4017865	VUID
N0000146218	NUI
D00665	KEGG_DRUG
113-92-8	SECONDARY_CAS_RN
1405-56-7	SECONDARY_CAS_RN
142429	RXNORM
4017864	VANDF
4017865	VANDF
4018446	VANDF
4019408	VANDF
C0008281	UMLSCUI
CHEBI:52010	CHEBI
CHEMBL505	ChEMBL_ID
CHEMBL1659	ChEMBL_ID
DB01114	DRUGBANK_ID
6976	IUPHAR_LIGAND_ID
2725	PUBCHEM_CID
32347	MMSL
32562	MMSL
3966	MMSL
4425	MMSL
4426	MMSL
4427	MMSL
4751	MMSL
93262	MMSL
d00191	MMSL
003391	NDDF
003392	NDDF
004430	NDDF
004431	NDDF
372914003	SNOMEDCT_US
438256006	SNOMEDCT_US
85737002	SNOMEDCT_US
9944001	SNOMEDCT_US
D002744	MESH_DESCRIPTOR_UI
CHEMBL1201659	ChEMBL_ID
104	INN_ID
3U6IO1965U	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Childrens Robitussin Nighttime Cough Long-Acting DM	HUMAN OTC DRUG LABEL	2	0031-8692	SOLUTION	2 mg	ORAL	OTC monograph final	17 sections
Childrens Robitussin Nighttime Cough Long-Acting DM	HUMAN OTC DRUG LABEL	2	0031-8692	SOLUTION	2 mg	ORAL	OTC monograph final	17 sections
CHILDRENS ROBITUSSIN COUGH AND COLD LONG-ACTING	HUMAN OTC DRUG LABEL	2	0031-8693	LIQUID	1 mg	ORAL	OTC monograph final	17 sections
TriaminicMulti-Symptom Fever and Cold	HUMAN OTC DRUG LABEL	4	0067-8116	SUSPENSION	1 mg	ORAL	OTC monograph final	15 sections
good sense cold	HUMAN OTC DRUG LABEL	4	0113-0903	SUSPENSION	1 mg	ORAL	OTC monograph final	15 sections
Allergy	HUMAN OTC DRUG LABEL	3	0113-2476	TABLET	2 mg	ORAL	OTC monograph final	15 sections
basic care childrens cold plus flu	HUMAN OTC DRUG LABEL	4	0113-7223	SUSPENSION	1 mg	ORAL	OTC monograph final	15 sections
FLONASEHeadache and Allergy Relief	HUMAN OTC DRUG LABEL	3	0135-0578	TABLET	2 mg	ORAL	OTC monograph final	17 sections
TussiCaps	HUMAN PRESCRIPTION DRUG LABEL	2	0187-0054	CAPSULE, EXTENDED RELEASE	4 mg	ORAL	ANDA	24 sections
TussiCaps	HUMAN PRESCRIPTION DRUG LABEL	2	0187-0108	CAPSULE, EXTENDED RELEASE	8 mg	ORAL	ANDA	24 sections
Alka-Seltzer Plus Severe Cold PowerFast FizzOrange Zest	HUMAN OTC DRUG LABEL	3	0280-0020	TABLET, EFFERVESCENT	2 mg	ORAL	OTC monograph final	17 sections
Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz	HUMAN OTC DRUG LABEL	4	0280-0022	TABLET, EFFERVESCENT	2 mg	ORAL	OTC monograph final	16 sections
Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz	HUMAN OTC DRUG LABEL	4	0280-0022	TABLET, EFFERVESCENT	2 mg	ORAL	OTC monograph final	16 sections
Alka-Seltzer Plus Severe Cold and Cough PowerFast Fizz	HUMAN OTC DRUG LABEL	4	0280-0023	TABLET, EFFERVESCENT	2 mg	ORAL	OTC monograph final	16 sections
Alka-Seltzer Plus Severe Cold and Cough PowerFast Fizz	HUMAN OTC DRUG LABEL	4	0280-0023	TABLET, EFFERVESCENT	2 mg	ORAL	OTC monograph final	16 sections
ANTIFLU	HUMAN OTC DRUG LABEL	3	0280-0044	TABLET, COATED	2 mg	ORAL	Export only	2 sections
Antiflupowder	HUMAN OTC DRUG LABEL	3	0280-0045	POWDER, FOR SOLUTION	4 mg	ORAL	Export only	1 sections
Antiflu Kids	HUMAN OTC DRUG LABEL	3	0280-0046	POWDER, FOR SOLUTION	1 mg	ORAL	Export only	2 sections
Alka-Seltzer Plus Maximum Strength Sinus Congestion and Pain PowerFast Fizz	HUMAN OTC DRUG LABEL	4	0280-0055	TABLET, EFFERVESCENT	2 mg	ORAL	OTC monograph final	15 sections
Alka-Seltzer Plus Cold Sparkling Original PowerFast Fizz	HUMAN OTC DRUG LABEL	3	0280-0060	TABLET, EFFERVESCENT	2 mg	ORAL	OTC monograph final	15 sections
Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz	HUMAN OTC DRUG LABEL	4	0280-0088	TABLET, EFFERVESCENT	2 mg	ORAL	OTC monograph final	16 sections
Alka-Seltzer Plus Maximum Strength Cold and Cough Power Max Gels	HUMAN OTC DRUG LABEL	4	0280-0092	CAPSULE, LIQUID FILLED	2 mg	ORAL	OTC monograph final	17 sections
Alka-Seltzer Plus Cold Medicine Sparkling Original	HUMAN OTC DRUG LABEL	3	0280-1400	TABLET, EFFERVESCENT	2 mg	ORAL	OTC monograph not final	17 sections
Alka-Seltzer Plus Cold Orange Zest	HUMAN OTC DRUG LABEL	3	0280-1510	TABLET, EFFERVESCENT	2 mg	ORAL	OTC monograph final	17 sections
Alka-Seltzer Plus Cold Sparkling Original	HUMAN OTC DRUG LABEL	3	0280-1520	TABLET, EFFERVESCENT	2 mg	ORAL	OTC monograph final	17 sections
Alka-Seltzer Plus Cold and Cough	HUMAN OTC DRUG LABEL	4	0280-1555	TABLET, EFFERVESCENT	2 mg	ORAL	OTC monograph final	16 sections
Alka-Seltzer Plus Severe Cold and Flu	HUMAN OTC DRUG LABEL	4	0280-1560	TABLET, EFFERVESCENT	2 mg	ORAL	OTC monograph final	17 sections
Alka-Seltzer Plus Maximum Strength Cold and Cough	HUMAN OTC DRUG LABEL	4	0280-1570	CAPSULE, LIQUID FILLED	2 mg	ORAL	OTC monograph final	17 sections
Childrens Plus Multi Symptom Cold	HUMAN OTC DRUG LABEL	4	0363-0034	SUSPENSION	1 mg	ORAL	OTC MONOGRAPH FINAL	15 sections
Childrens Plus Multi Symptom Cold	HUMAN OTC DRUG LABEL	4	0363-0034	SUSPENSION	1 mg	ORAL	OTC MONOGRAPH FINAL	15 sections