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chlorphenamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 616 | 132-22-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 12 | mg | O |
| 12 | mg | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 10 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.48 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 41 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 3.30 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 2.50 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.70 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 22 hours | Lombardo F, Berellini G, Obach RS |
| S (Water solubility) | 3 mg/mL | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 1.549 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.406 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 30.690 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 29.785 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 46.550 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 57.150 | % | High | 1 |
| herg | hERG pIC50 | 5.375 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 5.212 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 12.023 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 50.580 | % | High | 1 |
| kinase-safety-class | ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MET,NTRK2,PDK2,PDK4,PDPK1,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK | 44 | |||
| kinase-selectivity-class | AKT2,AKT3,AXL,EIF2AK3,PDK4,PRKCD,STK33 | 7 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 0.490 | High | 1 | |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 0.306 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 87.498 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 45.070 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 1.038 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 64.380 | % | High | 1 |
| rat-kpuu-brain | Rat brain Kpuu | 1.854 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 84.528 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 75.300 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 51.960 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 950.605 | uM | High | 1 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 15, 1950 | FDA | BAYER HEALTHCARE LLC |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug ineffective | 241.77 | 9.21 | 718 | 95683 | 1383580 | 89148466 |
| Chest discomfort | 143.45 | 9.21 | 396 | 96005 | 137969 | 90394077 |
| Drug intolerance | 136.76 | 9.21 | 165 | 96236 | 447426 | 90084620 |
| Contraindicated product administered | 133.78 | 9.21 | 88 | 96313 | 320051 | 90211995 |
| Dyspnoea | 110.64 | 9.21 | 1425 | 94976 | 879530 | 89652516 |
| Treatment failure | 109.78 | 9.21 | 97 | 96304 | 303831 | 90228215 |
| Cough | 105.69 | 9.21 | 713 | 95688 | 368249 | 90163797 |
| Neuropathy peripheral | 99.17 | 9.21 | 346 | 96055 | 136624 | 90395422 |
| Therapeutic product effect decreased | 90.48 | 9.21 | 97 | 96304 | 277474 | 90254572 |
| Pemphigus | 89.06 | 9.21 | 131 | 96270 | 326733 | 90205313 |
| Maternal exposure during pregnancy | 88.05 | 9.21 | 155 | 96246 | 359908 | 90172138 |
| Synovitis | 78.78 | 9.21 | 144 | 96257 | 329608 | 90202438 |
| Arthropathy | 73.17 | 9.21 | 177 | 96224 | 366065 | 90165981 |
| Glossodynia | 72.08 | 9.21 | 146 | 96255 | 321633 | 90210413 |
| Systemic lupus erythematosus | 69.87 | 9.21 | 178 | 96223 | 361718 | 90170328 |
| Hand deformity | 69.38 | 9.21 | 131 | 96270 | 296231 | 90235815 |
| Sinusitis | 69.14 | 9.21 | 611 | 95790 | 342477 | 90189569 |
| Flushing | 67.93 | 9.21 | 228 | 96173 | 88263 | 90443783 |
| Asthma | 65.71 | 9.21 | 462 | 95939 | 241698 | 90290348 |
| Joint swelling | 59.03 | 9.21 | 305 | 96096 | 502995 | 90029051 |
| Sinusitis fungal | 57.42 | 9.21 | 32 | 96369 | 1932 | 90530114 |
| Anaphylactic reaction | 57.29 | 9.21 | 214 | 96187 | 87310 | 90444736 |
| Anti-cyclic citrullinated peptide antibody positive | 56.66 | 9.21 | 103 | 96298 | 236330 | 90295716 |
| Neutropenic sepsis | 54.55 | 9.21 | 81 | 96320 | 18049 | 90513997 |
| Ejection fraction decreased | 54.25 | 9.21 | 99 | 96302 | 26154 | 90505892 |
| Pericarditis | 53.58 | 9.21 | 131 | 96270 | 270020 | 90262026 |
| Anxiety | 53.54 | 9.21 | 534 | 95867 | 309238 | 90222808 |
| Diarrhoea | 52.83 | 9.21 | 1339 | 95062 | 937851 | 89594195 |
| Nausea | 51.77 | 9.21 | 1545 | 94856 | 1108771 | 89423275 |
| Hepatic enzyme increased | 48.50 | 9.21 | 208 | 96193 | 360528 | 90171518 |
| Off label use | 48.34 | 9.21 | 854 | 95547 | 1101398 | 89430648 |
| Chest pain | 48.18 | 9.21 | 536 | 95865 | 319109 | 90212937 |
| Completed suicide | 48.01 | 9.21 | 50 | 96351 | 145008 | 90387038 |
| Sputum increased | 47.72 | 9.21 | 33 | 96368 | 2924 | 90529122 |
| Back pain | 47.41 | 9.21 | 531 | 95870 | 316644 | 90215402 |
| Salpingo-oophorectomy unilateral | 46.39 | 9.21 | 22 | 96379 | 946 | 90531100 |
| Wound | 45.61 | 9.21 | 167 | 96234 | 302813 | 90229233 |
| Rheumatoid arthritis | 45.21 | 9.21 | 215 | 96186 | 362399 | 90169647 |
| Abdominal discomfort | 44.00 | 9.21 | 312 | 96089 | 477016 | 90055030 |
| Nasal congestion | 42.70 | 9.21 | 189 | 96212 | 83225 | 90448821 |
| Deep vein thrombosis | 42.02 | 9.21 | 201 | 96200 | 91419 | 90440627 |
| Excessive eye blinking | 41.88 | 9.21 | 23 | 96378 | 1349 | 90530697 |
| Infective pulmonary exacerbation of cystic fibrosis | 41.60 | 9.21 | 53 | 96348 | 10226 | 90521820 |
| Diverticulum | 40.66 | 9.21 | 57 | 96344 | 12056 | 90519990 |
| Sleep apnoea syndrome | 38.09 | 9.21 | 96 | 96305 | 31651 | 90500395 |
| Eosinophilic colitis | 37.63 | 9.21 | 13 | 96388 | 241 | 90531805 |
| Pulmonary embolism | 37.47 | 9.21 | 253 | 96148 | 130567 | 90401479 |
| Rheumatoid factor positive | 37.46 | 9.21 | 79 | 96322 | 171571 | 90360475 |
| Therapeutic product effect incomplete | 35.39 | 9.21 | 98 | 96303 | 193798 | 90338248 |
| Throat tightness | 35.21 | 9.21 | 89 | 96312 | 29395 | 90502651 |
| Emotional distress | 35.09 | 9.21 | 102 | 96299 | 36560 | 90495486 |
| Palpitations | 34.82 | 9.21 | 257 | 96144 | 136471 | 90395575 |
| Headache | 34.46 | 9.21 | 1179 | 95222 | 861567 | 89670479 |
| Listless | 34.04 | 9.21 | 28 | 96373 | 3221 | 90528825 |
| Myelosuppression | 33.31 | 9.21 | 8 | 96393 | 53583 | 90478463 |
| Musculoskeletal stiffness | 32.88 | 9.21 | 183 | 96218 | 296349 | 90235697 |
| Swelling face | 32.73 | 9.21 | 172 | 96229 | 81180 | 90450866 |
| Duodenal ulcer perforation | 31.97 | 9.21 | 124 | 96277 | 221164 | 90310882 |
| Vertigo | 31.89 | 9.21 | 153 | 96248 | 69658 | 90462388 |
| Bronchospasm | 31.82 | 9.21 | 69 | 96332 | 20640 | 90511406 |
| Oropharyngeal pain | 31.34 | 9.21 | 220 | 96181 | 114967 | 90417079 |
| Product use issue | 31.18 | 9.21 | 214 | 96187 | 329705 | 90202341 |
| Reduced facial expression | 31.02 | 9.21 | 24 | 96377 | 2529 | 90529517 |
| Candida infection | 30.93 | 9.21 | 93 | 96308 | 33964 | 90498082 |
| Toxicity to various agents | 30.11 | 9.21 | 181 | 96220 | 287665 | 90244381 |
| Gallbladder polyp | 28.88 | 9.21 | 16 | 96385 | 955 | 90531091 |
| Urinary tract infection | 28.82 | 9.21 | 471 | 95930 | 305161 | 90226885 |
| Nail infection | 28.71 | 9.21 | 23 | 96378 | 2549 | 90529497 |
| Diastolic dysfunction | 28.41 | 9.21 | 37 | 96364 | 7296 | 90524750 |
| Chronic obstructive pulmonary disease | 28.27 | 9.21 | 154 | 96247 | 73675 | 90458371 |
| C-reactive protein increased | 27.93 | 9.21 | 99 | 96302 | 181290 | 90350756 |
| Discomfort | 27.92 | 9.21 | 174 | 96227 | 274161 | 90257885 |
| Drug interaction | 27.79 | 9.21 | 176 | 96225 | 276277 | 90255769 |
| Foetal exposure during pregnancy | 27.54 | 9.21 | 6 | 96395 | 42969 | 90489077 |
| Embolism venous | 27.51 | 9.21 | 26 | 96375 | 3594 | 90528452 |
| Hiccups | 27.44 | 9.21 | 24 | 96377 | 3002 | 90529044 |
| Helicobacter infection | 27.38 | 9.21 | 136 | 96265 | 226714 | 90305332 |
| General physical health deterioration | 26.76 | 9.21 | 245 | 96156 | 354870 | 90177176 |
| Dilatation intrahepatic duct acquired | 26.60 | 9.21 | 14 | 96387 | 754 | 90531292 |
| Bronchitis | 26.56 | 9.21 | 264 | 96137 | 152663 | 90379383 |
| Myalgia | 26.50 | 9.21 | 294 | 96107 | 174831 | 90357215 |
| Vulvovaginal candidiasis | 25.87 | 9.21 | 26 | 96375 | 3874 | 90528172 |
| Oxygen saturation decreased | 25.66 | 9.21 | 199 | 96202 | 107284 | 90424762 |
| Dizziness | 25.18 | 9.21 | 812 | 95589 | 588472 | 89943574 |
| Infusion site erythema | 25.08 | 9.21 | 49 | 96352 | 13621 | 90518425 |
| Lip swelling | 24.92 | 9.21 | 94 | 96307 | 38516 | 90493530 |
| Iron deficiency anaemia | 24.76 | 9.21 | 68 | 96333 | 23594 | 90508452 |
| Condition aggravated | 24.54 | 9.21 | 466 | 95935 | 595079 | 89936967 |
| Swelling | 24.37 | 9.21 | 307 | 96094 | 418751 | 90113295 |
| Therapy non-responder | 24.27 | 9.21 | 70 | 96331 | 136634 | 90395412 |
| Emphysema | 24.06 | 9.21 | 45 | 96356 | 12110 | 90519936 |
| Mucosal inflammation | 23.98 | 9.21 | 123 | 96278 | 57502 | 90474544 |
| Arthralgia | 23.90 | 9.21 | 638 | 95763 | 777884 | 89754162 |
| Delusion of replacement | 23.74 | 9.21 | 6 | 96395 | 34 | 90532012 |
| Acute respiratory failure | 23.30 | 9.21 | 99 | 96302 | 42819 | 90489227 |
| Apathy | 23.27 | 9.21 | 42 | 96359 | 10998 | 90521048 |
| Neutropenia | 23.24 | 9.21 | 352 | 96049 | 224552 | 90307494 |
| Hypoxia | 23.16 | 9.21 | 144 | 96257 | 72255 | 90459791 |
| Rhinorrhoea | 22.48 | 9.21 | 166 | 96235 | 88150 | 90443896 |
| Constipation | 22.45 | 9.21 | 421 | 95980 | 279974 | 90252072 |
| Feeling hot | 22.41 | 9.21 | 151 | 96250 | 77857 | 90454189 |
| Respiratory symptom | 22.27 | 9.21 | 25 | 96376 | 4227 | 90527819 |
| Premature delivery | 21.82 | 9.21 | 7 | 96394 | 38755 | 90493291 |
| Tricuspid valve incompetence | 21.56 | 9.21 | 52 | 96349 | 16679 | 90515367 |
| Nasal discomfort | 21.50 | 9.21 | 28 | 96373 | 5520 | 90526526 |
| Tonsillar hypertrophy | 21.11 | 9.21 | 14 | 96387 | 1158 | 90530888 |
| Band sensation | 21.10 | 9.21 | 14 | 96387 | 1159 | 90530887 |
| Pneumonia | 21.07 | 9.21 | 854 | 95547 | 637205 | 89894841 |
| Foreign body | 21.06 | 9.21 | 19 | 96382 | 2475 | 90529571 |
| Lacrimation increased | 21.00 | 9.21 | 70 | 96331 | 26992 | 90505054 |
| Acute kidney injury | 20.82 | 9.21 | 229 | 96172 | 320158 | 90211888 |
| Acute sinusitis | 20.54 | 9.21 | 24 | 96377 | 4237 | 90527809 |
| Necrotic lymphadenopathy | 20.50 | 9.21 | 7 | 96394 | 125 | 90531921 |
| Poor quality device used | 20.42 | 9.21 | 18 | 96383 | 2275 | 90529771 |
| Agranulocytosis | 20.28 | 9.21 | 6 | 96395 | 34996 | 90497050 |
| Seasonal allergy | 20.15 | 9.21 | 62 | 96339 | 22921 | 90509125 |
| Retinal detachment | 19.84 | 9.21 | 30 | 96371 | 6792 | 90525254 |
| Red blood cell sedimentation rate increased | 19.75 | 9.21 | 36 | 96365 | 82559 | 90449487 |
| Hip arthroplasty | 19.33 | 9.21 | 32 | 96369 | 76176 | 90455870 |
| Upper respiratory tract infection | 19.21 | 9.21 | 215 | 96186 | 128103 | 90403943 |
| Chemical burns of eye | 19.19 | 9.21 | 6 | 96395 | 80 | 90531966 |
| Hiatus hernia | 19.15 | 9.21 | 65 | 96336 | 25296 | 90506750 |
| Blister infected | 19.14 | 9.21 | 12 | 96389 | 901 | 90531145 |
| Hepatocellular injury | 18.64 | 9.21 | 4 | 96397 | 28954 | 90503092 |
| Muscle injury | 18.51 | 9.21 | 111 | 96290 | 176543 | 90355503 |
| Vascular compression | 18.43 | 9.21 | 8 | 96393 | 279 | 90531767 |
| Hyperlipidaemia | 18.43 | 9.21 | 60 | 96341 | 22856 | 90509190 |
| Catheter site bruise | 18.41 | 9.21 | 10 | 96391 | 574 | 90531472 |
| Alopecia | 18.40 | 9.21 | 394 | 96007 | 494677 | 90037369 |
| Sinus disorder | 18.34 | 9.21 | 79 | 96322 | 34368 | 90497678 |
| Rhinitis allergic | 18.33 | 9.21 | 49 | 96352 | 16736 | 90515310 |
| Biliary sepsis | 18.30 | 9.21 | 12 | 96389 | 974 | 90531072 |
| Liver injury | 17.96 | 9.21 | 107 | 96294 | 170460 | 90361586 |
| Atrial fibrillation | 17.85 | 9.21 | 219 | 96182 | 133392 | 90398654 |
| Diverticulitis | 17.80 | 9.21 | 95 | 96306 | 45092 | 90486954 |
| Rheumatic fever | 17.78 | 9.21 | 93 | 96308 | 153028 | 90379018 |
| Drug reaction with eosinophilia and systemic symptoms | 17.50 | 9.21 | 12 | 96389 | 42746 | 90489300 |
| Psoriatic arthropathy | 17.42 | 9.21 | 157 | 96244 | 228178 | 90303868 |
| C-reactive protein abnormal | 17.39 | 9.21 | 73 | 96328 | 127356 | 90404690 |
| Malignant neoplasm progression | 17.35 | 9.21 | 57 | 96344 | 106813 | 90425233 |
| Head discomfort | 17.15 | 9.21 | 47 | 96354 | 16286 | 90515760 |
| Multi-organ disorder | 17.10 | 9.21 | 16 | 96385 | 2184 | 90529862 |
| Pain in jaw | 16.98 | 9.21 | 98 | 96303 | 47887 | 90484159 |
| Adverse event | 16.82 | 9.21 | 66 | 96335 | 117352 | 90414694 |
| Tachycardia | 16.76 | 9.21 | 248 | 96153 | 157425 | 90374621 |
| Sopor | 16.71 | 9.21 | 3 | 96398 | 24641 | 90507405 |
| Polyglandular disorder | 16.61 | 9.21 | 7 | 96394 | 227 | 90531819 |
| Cholecystitis chronic | 16.56 | 9.21 | 34 | 96367 | 9792 | 90522254 |
| Muscle spasms | 16.45 | 9.21 | 367 | 96034 | 251516 | 90280530 |
| Nasal polyps | 16.43 | 9.21 | 36 | 96365 | 10844 | 90521202 |
| Flatulence | 16.32 | 9.21 | 87 | 96314 | 41280 | 90490766 |
| Infusion site nodule | 16.30 | 9.21 | 14 | 96387 | 1709 | 90530337 |
| Drug resistance | 16.28 | 9.21 | 6 | 96395 | 30443 | 90501603 |
| Erythema | 16.25 | 9.21 | 338 | 96063 | 228908 | 90303138 |
| Lethargy | 16.25 | 9.21 | 119 | 96282 | 63020 | 90469026 |
| Rhinitis | 16.24 | 9.21 | 41 | 96360 | 13531 | 90518515 |
| Drug tolerance decreased | 16.08 | 9.21 | 7 | 96394 | 32123 | 90499923 |
| Hysterectomy | 16.01 | 9.21 | 37 | 96364 | 11547 | 90520499 |
| Infusion site swelling | 15.72 | 9.21 | 37 | 96364 | 11683 | 90520363 |
| Mood swings | 15.58 | 9.21 | 53 | 96348 | 20649 | 90511397 |
| Vestibular neuronitis | 15.50 | 9.21 | 10 | 96391 | 789 | 90531257 |
| Folliculitis | 15.37 | 9.21 | 141 | 96260 | 204212 | 90327834 |
| Acute interstitial pneumonitis | 15.28 | 9.21 | 10 | 96391 | 809 | 90531237 |
| Panic attack | 15.24 | 9.21 | 62 | 96339 | 26303 | 90505743 |
| Mobility decreased | 15.19 | 9.21 | 182 | 96219 | 250552 | 90281494 |
| Prescription drug used without a prescription | 15.14 | 9.21 | 18 | 96383 | 3237 | 90528809 |
| Macular degeneration | 15.09 | 9.21 | 11 | 96390 | 37959 | 90494087 |
| Product dose omission issue | 14.88 | 9.21 | 411 | 95990 | 291276 | 90240770 |
| Ventricular extrasystoles | 14.79 | 9.21 | 39 | 96362 | 13211 | 90518835 |
| Confusional arousal | 14.74 | 9.21 | 7 | 96394 | 302 | 90531744 |
| Presyncope | 14.74 | 9.21 | 70 | 96331 | 31735 | 90500311 |
| Infusion site pruritus | 14.60 | 9.21 | 26 | 96375 | 6739 | 90525307 |
| Essential hypertension | 14.57 | 9.21 | 25 | 96376 | 6290 | 90525756 |
| Impaired healing | 14.57 | 9.21 | 169 | 96232 | 234030 | 90298016 |
| Pain | 14.55 | 9.21 | 890 | 95511 | 995451 | 89536595 |
| Abdominal pain | 14.53 | 9.21 | 536 | 95865 | 395185 | 90136861 |
| Retching | 14.37 | 9.21 | 49 | 96352 | 19110 | 90512936 |
| Prescribed underdose | 14.37 | 9.21 | 37 | 96364 | 74982 | 90457064 |
| Nasal turbinate hypertrophy | 14.21 | 9.21 | 10 | 96391 | 911 | 90531135 |
| Sinus tachycardia | 14.13 | 9.21 | 64 | 96337 | 28449 | 90503597 |
| Lactic acidosis | 13.94 | 9.21 | 20 | 96381 | 50443 | 90481603 |
| Swollen joint count increased | 13.79 | 9.21 | 66 | 96335 | 111140 | 90420906 |
| Intentional product use issue | 13.69 | 9.21 | 156 | 96245 | 216736 | 90315310 |
| Hypervolaemia | 13.68 | 9.21 | 70 | 96331 | 32687 | 90499359 |
| Neuralgia | 13.64 | 9.21 | 68 | 96333 | 31432 | 90500614 |
| Terminal ileitis | 13.57 | 9.21 | 11 | 96390 | 1239 | 90530807 |
| Vision blurred | 13.54 | 9.21 | 178 | 96223 | 110115 | 90421931 |
| Tubulointerstitial nephritis | 13.54 | 9.21 | 5 | 96396 | 25338 | 90506708 |
| Inflammation | 13.53 | 9.21 | 123 | 96278 | 178469 | 90353577 |
| Haemodialysis complication | 13.52 | 9.21 | 6 | 96395 | 221 | 90531825 |
| Drug ineffective for unapproved indication | 13.45 | 9.21 | 32 | 96369 | 66612 | 90465434 |
| Multiple allergies | 13.41 | 9.21 | 41 | 96360 | 15105 | 90516941 |
| Oedema peripheral | 13.32 | 9.21 | 364 | 96037 | 257551 | 90274495 |
| Pyrexia | 13.29 | 9.21 | 843 | 95558 | 659642 | 89872404 |
| Blister | 13.28 | 9.21 | 191 | 96210 | 254807 | 90277239 |
| Transient ischaemic attack | 13.26 | 9.21 | 85 | 96316 | 43091 | 90488955 |
| Hyperkalaemia | 13.26 | 9.21 | 31 | 96370 | 64933 | 90467113 |
| Swollen tongue | 13.22 | 9.21 | 89 | 96312 | 45867 | 90486179 |
| Laryngospasm | 13.20 | 9.21 | 17 | 96384 | 3316 | 90528730 |
| Irritable bowel syndrome | 13.18 | 9.21 | 149 | 96252 | 207299 | 90324747 |
| Drug hypersensitivity | 13.14 | 9.21 | 384 | 96017 | 463225 | 90068821 |
| Biliary dyskinesia | 13.13 | 9.21 | 15 | 96386 | 2584 | 90529462 |
| Anhedonia | 13.12 | 9.21 | 34 | 96367 | 11397 | 90520649 |
| Anosmia | 13.11 | 9.21 | 31 | 96370 | 9817 | 90522229 |
| Cyanosis | 13.08 | 9.21 | 48 | 96353 | 19407 | 90512639 |
| Knee arthroplasty | 13.07 | 9.21 | 45 | 96356 | 83137 | 90448909 |
| Ageusia | 12.84 | 9.21 | 42 | 96359 | 16034 | 90516012 |
| Obstructive airways disorder | 12.77 | 9.21 | 58 | 96343 | 25811 | 90506235 |
| Axillary pain | 12.76 | 9.21 | 14 | 96387 | 2307 | 90529739 |
| Disease recurrence | 12.74 | 9.21 | 76 | 96325 | 37577 | 90494469 |
| Cholestasis | 12.59 | 9.21 | 12 | 96389 | 36287 | 90495759 |
| Peripheral pulse decreased | 12.55 | 9.21 | 4 | 96397 | 57 | 90531989 |
| Dyspnoea at rest | 12.44 | 9.21 | 20 | 96381 | 4771 | 90527275 |
| Sleep disorder due to general medical condition, insomnia type | 12.38 | 9.21 | 83 | 96318 | 128611 | 90403435 |
| Therapy partial responder | 12.38 | 9.21 | 4 | 96397 | 22039 | 90510007 |
| Coma | 12.30 | 9.21 | 38 | 96363 | 72594 | 90459452 |
| Chronic hepatitis | 12.27 | 9.21 | 10 | 96391 | 1135 | 90530911 |
| Bronchial haemorrhage | 12.25 | 9.21 | 8 | 96393 | 645 | 90531401 |
| Chronic sinusitis | 12.23 | 9.21 | 54 | 96347 | 23748 | 90508298 |
| Incorrect dose administered | 12.16 | 9.21 | 133 | 96268 | 78797 | 90453249 |
| Poor peripheral circulation | 12.13 | 9.21 | 18 | 96383 | 4007 | 90528039 |
| Type 2 diabetes mellitus | 12.13 | 9.21 | 148 | 96253 | 203096 | 90328950 |
| Gastrooesophageal reflux disease | 12.03 | 9.21 | 246 | 96155 | 166091 | 90365955 |
| Diffuse large B-cell lymphoma refractory | 11.94 | 9.21 | 12 | 96389 | 1788 | 90530258 |
| Neutropenic infection | 11.89 | 9.21 | 12 | 96389 | 1797 | 90530249 |
| Premature baby | 11.73 | 9.21 | 6 | 96395 | 25071 | 90506975 |
| Administration site extravasation | 11.65 | 9.21 | 10 | 96391 | 1220 | 90530826 |
| Pulmonary fibrosis | 11.55 | 9.21 | 67 | 96334 | 107436 | 90424610 |
| Tinnitus | 11.53 | 9.21 | 82 | 96319 | 43020 | 90489026 |
| Sedation | 11.51 | 9.21 | 21 | 96380 | 48150 | 90483896 |
| Low turnover osteopathy | 11.49 | 9.21 | 18 | 96383 | 4200 | 90527846 |
| Pelvic fracture | 11.48 | 9.21 | 39 | 96362 | 15180 | 90516866 |
| Coronary artery disease | 11.46 | 9.21 | 68 | 96333 | 33555 | 90498491 |
| Cellulitis | 11.46 | 9.21 | 148 | 96253 | 91189 | 90440857 |
| Gastrointestinal disorder | 11.44 | 9.21 | 198 | 96203 | 256489 | 90275557 |
| Gastroenteritis viral | 11.40 | 9.21 | 63 | 96338 | 30292 | 90501754 |
| Victim of chemical submission | 11.35 | 9.21 | 8 | 96393 | 731 | 90531315 |
| Autoimmune haemolytic anaemia | 11.30 | 9.21 | 21 | 96380 | 5624 | 90526422 |
| Product use in unapproved indication | 11.23 | 9.21 | 272 | 96129 | 335964 | 90196082 |
| Bronchial neoplasm | 11.20 | 9.21 | 7 | 96394 | 523 | 90531523 |
| Toxic encephalopathy | 11.17 | 9.21 | 27 | 96374 | 8672 | 90523374 |
| Blood cholesterol increased | 11.12 | 9.21 | 155 | 96246 | 207857 | 90324189 |
| Haemorrhoids | 11.11 | 9.21 | 57 | 96344 | 26645 | 90505401 |
| Oral pain | 11.08 | 9.21 | 66 | 96335 | 32617 | 90499429 |
| Nail dystrophy | 11.05 | 9.21 | 10 | 96391 | 1308 | 90530738 |
| Abnormal sensation in eye | 11.03 | 9.21 | 12 | 96389 | 1959 | 90530087 |
| Prosopagnosia | 11.03 | 9.21 | 4 | 96397 | 86 | 90531960 |
| Anaemia folate deficiency | 11.01 | 9.21 | 7 | 96394 | 539 | 90531507 |
| Gallbladder disorder | 11.00 | 9.21 | 46 | 96355 | 19757 | 90512289 |
| Necrotising colitis | 10.92 | 9.21 | 10 | 96391 | 1328 | 90530718 |
| Periorbital oedema | 10.84 | 9.21 | 23 | 96378 | 6776 | 90525270 |
| Irritability | 10.83 | 9.21 | 70 | 96331 | 35592 | 90496454 |
| Impaired quality of life | 10.77 | 9.21 | 51 | 96350 | 23093 | 90508953 |
| Depression | 10.75 | 9.21 | 406 | 95995 | 300195 | 90231851 |
| Cytomegalovirus test positive | 10.74 | 9.21 | 16 | 96385 | 3575 | 90528471 |
| Epilepsy | 10.66 | 9.21 | 48 | 96353 | 82158 | 90449888 |
| Pulmonary function test decreased | 10.65 | 9.21 | 18 | 96383 | 4476 | 90527570 |
| Viral infection | 10.62 | 9.21 | 78 | 96323 | 41336 | 90490710 |
| Product quality issue | 10.58 | 9.21 | 130 | 96271 | 79195 | 90452851 |
| Nasal herpes | 10.55 | 9.21 | 8 | 96393 | 818 | 90531228 |
| Faeces hard | 10.50 | 9.21 | 15 | 96386 | 3227 | 90528819 |
| Catheter site haemorrhage | 10.48 | 9.21 | 16 | 96385 | 3652 | 90528394 |
| Pancreatitis chronic | 10.48 | 9.21 | 14 | 96387 | 2829 | 90529217 |
| Sinus headache | 10.44 | 9.21 | 22 | 96379 | 6454 | 90525592 |
| Eosinophilia | 10.41 | 9.21 | 9 | 96392 | 28524 | 90503522 |
| Cardiac failure congestive | 10.39 | 9.21 | 155 | 96246 | 98539 | 90433507 |
| Adverse drug reaction | 10.37 | 9.21 | 77 | 96324 | 116624 | 90415422 |
| Wheezing | 10.37 | 9.21 | 329 | 96072 | 237751 | 90294295 |
| Food allergy | 10.33 | 9.21 | 54 | 96347 | 25424 | 90506622 |
| Appendicitis | 10.31 | 9.21 | 29 | 96372 | 10202 | 90521844 |
| Urticaria | 10.15 | 9.21 | 418 | 95983 | 312316 | 90219730 |
| Aerophagia | 10.12 | 9.21 | 3 | 96398 | 33 | 90532013 |
| Stomatitis | 10.07 | 9.21 | 219 | 96182 | 274479 | 90257567 |
| Escherichia urinary tract infection | 10.07 | 9.21 | 35 | 96366 | 13780 | 90518266 |
| Exercise test abnormal | 10.04 | 9.21 | 4 | 96397 | 112 | 90531934 |
| Polyneuropathy | 10.02 | 9.21 | 4 | 96397 | 19337 | 90512709 |
| Hyperhidrosis | 9.99 | 9.21 | 202 | 96199 | 136103 | 90395943 |
| Rhonchi | 9.97 | 9.21 | 14 | 96387 | 2964 | 90529082 |
| Plantar fasciitis | 9.97 | 9.21 | 17 | 96384 | 4257 | 90527789 |
| Body mass index increased | 9.97 | 9.21 | 10 | 96391 | 1487 | 90530559 |
| Blood magnesium decreased | 9.96 | 9.21 | 38 | 96363 | 15655 | 90516391 |
| Hypoacusis | 9.93 | 9.21 | 57 | 96344 | 27793 | 90504253 |
| Blood pressure fluctuation | 9.92 | 9.21 | 26 | 96375 | 52387 | 90479659 |
| Vitamin D deficiency | 9.92 | 9.21 | 41 | 96360 | 17515 | 90514531 |
| Nystagmus | 9.90 | 9.21 | 23 | 96378 | 7204 | 90524842 |
| Hyperpyrexia | 9.89 | 9.21 | 18 | 96383 | 4743 | 90527303 |
| Hereditary angioedema | 9.89 | 9.21 | 27 | 96374 | 9338 | 90522708 |
| Haemoptysis | 9.87 | 9.21 | 65 | 96336 | 33255 | 90498791 |
| Joint stiffness | 9.86 | 9.21 | 46 | 96355 | 77996 | 90454050 |
| Transferrin saturation decreased | 9.86 | 9.21 | 8 | 96393 | 903 | 90531143 |
| Intentional self-injury | 9.83 | 9.21 | 10 | 96391 | 29324 | 90502722 |
| Febrile neutropenia | 9.80 | 9.21 | 229 | 96172 | 158120 | 90373926 |
| Grip strength decreased | 9.78 | 9.21 | 58 | 96343 | 92518 | 90439528 |
| Pulmonary hypertension | 9.74 | 9.21 | 78 | 96323 | 42445 | 90489601 |
| Infusion site bruising | 9.69 | 9.21 | 17 | 96384 | 4355 | 90527691 |
| Actinic elastosis | 9.67 | 9.21 | 3 | 96398 | 39 | 90532007 |
| Urinary retention | 9.63 | 9.21 | 71 | 96330 | 37673 | 90494373 |
| Therapeutic response decreased | 9.59 | 9.21 | 56 | 96345 | 89673 | 90442373 |
| Obstructive defaecation | 9.57 | 9.21 | 5 | 96396 | 265 | 90531781 |
| Eosinophilic myocarditis | 9.57 | 9.21 | 7 | 96394 | 678 | 90531368 |
| Dermatitis contact | 9.53 | 9.21 | 34 | 96367 | 13561 | 90518485 |
| Osteopenia | 9.50 | 9.21 | 49 | 96352 | 22953 | 90509093 |
| Intervertebral disc degeneration | 9.49 | 9.21 | 40 | 96361 | 17234 | 90514812 |
| Endocrine disorder | 9.49 | 9.21 | 8 | 96393 | 952 | 90531094 |
| Hypoaesthesia eye | 9.48 | 9.21 | 6 | 96395 | 458 | 90531588 |
| Immobile | 9.47 | 9.21 | 21 | 96380 | 6377 | 90525669 |
| Exposure during pregnancy | 9.35 | 9.21 | 188 | 96213 | 238222 | 90293824 |
| Tidal volume decreased | 9.33 | 9.21 | 3 | 96398 | 44 | 90532002 |
| Stoma site dermatitis | 9.30 | 9.21 | 5 | 96396 | 281 | 90531765 |
| Urethral stenosis | 9.25 | 9.21 | 5 | 96396 | 284 | 90531762 |
| Anal incontinence | 9.25 | 9.21 | 38 | 96363 | 16192 | 90515854 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Delusion of grandeur | 110.50 | 11.26 | 50 | 44917 | 1946 | 42574422 |
| Rhinalgia | 101.47 | 11.26 | 46 | 44921 | 1798 | 42574570 |
| Lower respiratory tract infection | 96.05 | 11.26 | 163 | 44804 | 41043 | 42535325 |
| Drug ineffective | 86.94 | 11.26 | 357 | 44610 | 629840 | 41946528 |
| Lymphocyte count abnormal | 85.11 | 11.26 | 43 | 44924 | 2144 | 42574224 |
| Affective disorder | 79.41 | 11.26 | 59 | 44908 | 5901 | 42570467 |
| Upper respiratory tract infection | 57.22 | 11.26 | 133 | 44834 | 42040 | 42534328 |
| Schizophrenia | 50.56 | 11.26 | 59 | 44908 | 10491 | 42565877 |
| Asthma | 49.94 | 11.26 | 162 | 44805 | 62152 | 42514216 |
| Sinusitis | 48.36 | 11.26 | 134 | 44833 | 47158 | 42529210 |
| SARS-CoV-2 test positive | 46.09 | 11.26 | 50 | 44917 | 8210 | 42568158 |
| Drug therapy | 38.03 | 11.26 | 40 | 44927 | 6340 | 42570028 |
| Analgesic therapy | 37.29 | 11.26 | 40 | 44927 | 6484 | 42569884 |
| Sleep disorder therapy | 37.19 | 11.26 | 41 | 44926 | 6853 | 42569515 |
| Painful respiration | 36.66 | 11.26 | 21 | 44946 | 1348 | 42575020 |
| Hyperphosphataemia | 36.51 | 11.26 | 56 | 44911 | 12948 | 42563420 |
| Urticaria | 35.10 | 11.26 | 163 | 44804 | 73873 | 42502495 |
| Neuralgia | 34.90 | 11.26 | 81 | 44886 | 25566 | 42550802 |
| Dyspepsia | 34.48 | 11.26 | 109 | 44858 | 41243 | 42535125 |
| Cellulitis | 34.06 | 11.26 | 142 | 44825 | 61443 | 42514925 |
| Acute kidney injury | 33.76 | 11.26 | 238 | 44729 | 367099 | 42209269 |
| Chest injury | 33.55 | 11.26 | 22 | 44945 | 1800 | 42574568 |
| Infective pulmonary exacerbation of cystic fibrosis | 33.01 | 11.26 | 41 | 44926 | 7777 | 42568591 |
| Hypophosphataemia | 31.69 | 11.26 | 69 | 44898 | 20876 | 42555492 |
| Constipation | 31.58 | 11.26 | 285 | 44682 | 162006 | 42414362 |
| Bronchopulmonary aspergillosis allergic | 31.36 | 11.26 | 31 | 44936 | 4567 | 42571801 |
| Drug interaction | 31.36 | 11.26 | 160 | 44807 | 266839 | 42309529 |
| Alopecia | 29.96 | 11.26 | 83 | 44884 | 29193 | 42547175 |
| Anticoagulant therapy | 29.87 | 11.26 | 30 | 44937 | 4505 | 42571863 |
| Flushing | 29.42 | 11.26 | 96 | 44871 | 36932 | 42539436 |
| Lactic acidosis | 29.33 | 11.26 | 6 | 44961 | 45255 | 42531113 |
| Dyspnoea | 29.03 | 11.26 | 640 | 44327 | 441981 | 42134387 |
| Antacid therapy | 28.88 | 11.26 | 30 | 44937 | 4687 | 42571681 |
| Treatment failure | 28.86 | 11.26 | 15 | 44952 | 62609 | 42513759 |
| Drug hypersensitivity | 28.48 | 11.26 | 191 | 44776 | 99198 | 42477170 |
| Extrapyramidal disorder | 28.25 | 11.26 | 57 | 44910 | 16355 | 42560013 |
| Infusion related reaction | 28.17 | 11.26 | 133 | 44834 | 60673 | 42515695 |
| Lip swelling | 27.95 | 11.26 | 62 | 44905 | 18991 | 42557377 |
| Myasthenia gravis | 27.72 | 11.26 | 56 | 44911 | 16081 | 42560287 |
| Neutropenic sepsis | 26.99 | 11.26 | 55 | 44912 | 15891 | 42560477 |
| Renal failure | 26.83 | 11.26 | 71 | 44896 | 143655 | 42432713 |
| Stress | 26.07 | 11.26 | 104 | 44863 | 44108 | 42532260 |
| Therapeutic product effect incomplete | 25.94 | 11.26 | 22 | 44945 | 70917 | 42505451 |
| Drug resistance | 25.68 | 11.26 | 3 | 44964 | 34245 | 42542123 |
| Congenital hiatus hernia | 25.46 | 11.26 | 32 | 44935 | 6142 | 42570226 |
| Hallucination, auditory | 24.84 | 11.26 | 51 | 44916 | 14813 | 42561555 |
| Gout | 24.35 | 11.26 | 75 | 44892 | 27980 | 42548388 |
| Fatigue | 24.29 | 11.26 | 616 | 44351 | 435025 | 42141343 |
| Walking aid user | 24.26 | 11.26 | 21 | 44946 | 2612 | 42573756 |
| Failure to anastomose | 24.11 | 11.26 | 9 | 44958 | 212 | 42576156 |
| Pleuritic pain | 23.51 | 11.26 | 33 | 44934 | 7044 | 42569324 |
| Myelosuppression | 23.05 | 11.26 | 7 | 44960 | 40454 | 42535914 |
| Cough | 23 | 11.26 | 288 | 44679 | 177815 | 42398553 |
| Death | 22.81 | 11.26 | 355 | 44612 | 470830 | 42105538 |
| Neutrophil count increased | 21.11 | 11.26 | 57 | 44910 | 19747 | 42556621 |
| Pyrexia | 21.02 | 11.26 | 554 | 44413 | 393488 | 42182880 |
| Chronic obstructive pulmonary disease | 20.99 | 11.26 | 126 | 44841 | 62988 | 42513380 |
| Oropharyngeal blistering | 20.84 | 11.26 | 8 | 44959 | 204 | 42576164 |
| Hyperkalaemia | 20.74 | 11.26 | 33 | 44934 | 80425 | 42495943 |
| Off label use | 20.59 | 11.26 | 515 | 44452 | 637820 | 41938548 |
| Dry mouth | 20.53 | 11.26 | 90 | 44877 | 39789 | 42536579 |
| Troponin increased | 20.46 | 11.26 | 55 | 44912 | 19007 | 42557361 |
| Blood calcium increased | 20.42 | 11.26 | 34 | 44933 | 8420 | 42567948 |
| Interstitial lung disease | 20.39 | 11.26 | 32 | 44935 | 78430 | 42497938 |
| Ear infection | 20.31 | 11.26 | 43 | 44924 | 12761 | 42563607 |
| Hyperlipidaemia | 20.07 | 11.26 | 59 | 44908 | 21457 | 42554911 |
| Swelling | 19.82 | 11.26 | 112 | 44855 | 54773 | 42521595 |
| Personality change | 19.50 | 11.26 | 27 | 44940 | 5692 | 42570676 |
| Sleep disorder | 19.30 | 11.26 | 101 | 44866 | 47994 | 42528374 |
| Pulmonary embolism | 19.29 | 11.26 | 202 | 44765 | 119410 | 42456958 |
| Incorrect route of product administration | 19.29 | 11.26 | 63 | 44904 | 24242 | 42552126 |
| Bronchitis | 18.85 | 11.26 | 99 | 44868 | 47102 | 42529266 |
| Hypersomnia | 18.62 | 11.26 | 45 | 44922 | 14573 | 42561795 |
| Hypoacusis | 18.13 | 11.26 | 52 | 44915 | 18650 | 42557718 |
| Feeling cold | 17.68 | 11.26 | 41 | 44926 | 12932 | 42563436 |
| Neutropenic infection | 17.38 | 11.26 | 15 | 44952 | 1858 | 42574510 |
| Contraindicated product administered | 17.12 | 11.26 | 3 | 44964 | 25269 | 42551099 |
| Pneumonia | 16.68 | 11.26 | 572 | 44395 | 421577 | 42154791 |
| Neuropathy peripheral | 16.41 | 11.26 | 172 | 44795 | 101681 | 42474687 |
| Malignant neoplasm progression | 16.35 | 11.26 | 59 | 44908 | 108341 | 42468027 |
| Abnormal behaviour | 16.22 | 11.26 | 63 | 44904 | 26388 | 42549980 |
| Benign prostatic hyperplasia | 16.20 | 11.26 | 54 | 44913 | 20998 | 42555370 |
| Drug ineffective for unapproved indication | 16.05 | 11.26 | 15 | 44952 | 46148 | 42530220 |
| Intentional product misuse | 15.98 | 11.26 | 116 | 44851 | 61784 | 42514584 |
| Renal impairment | 15.97 | 11.26 | 61 | 44906 | 110167 | 42466201 |
| Toxic epidermal necrolysis | 15.83 | 11.26 | 63 | 44904 | 26687 | 42549681 |
| Tonsillitis | 15.75 | 11.26 | 17 | 44950 | 2774 | 42573594 |
| Rhabdomyolysis | 15.75 | 11.26 | 37 | 44930 | 77982 | 42498386 |
| Bronchospasm | 15.70 | 11.26 | 39 | 44928 | 12846 | 42563522 |
| Nasal congestion | 15.51 | 11.26 | 67 | 44900 | 29434 | 42546934 |
| Nasal discomfort | 15.36 | 11.26 | 13 | 44954 | 1569 | 42574799 |
| Febrile neutropenia | 15.27 | 11.26 | 278 | 44689 | 185425 | 42390943 |
| Lymphocyte count decreased | 15.27 | 11.26 | 64 | 44903 | 27745 | 42548623 |
| Activated partial thromboplastin time prolonged | 15.21 | 11.26 | 44 | 44923 | 15859 | 42560509 |
| Bacterial infection | 15.18 | 11.26 | 64 | 44903 | 27815 | 42548553 |
| Chills | 14.76 | 11.26 | 158 | 44809 | 93908 | 42482460 |
| Coma | 14.73 | 11.26 | 21 | 44946 | 53533 | 42522835 |
| Bradycardia | 14.63 | 11.26 | 44 | 44923 | 85440 | 42490928 |
| Foetal exposure during pregnancy | 14.62 | 11.26 | 17 | 44950 | 47294 | 42529074 |
| Rheumatoid arthritis | 14.51 | 11.26 | 14 | 44953 | 42426 | 42533942 |
| Rhinitis allergic | 14.41 | 11.26 | 19 | 44948 | 3823 | 42572545 |
| Cystic fibrosis | 14.28 | 11.26 | 14 | 44953 | 2041 | 42574327 |
| Incorrect dose administered | 14.09 | 11.26 | 100 | 44867 | 52874 | 42523494 |
| Tremor | 13.92 | 11.26 | 160 | 44807 | 96769 | 42479599 |
| Oral candidiasis | 13.91 | 11.26 | 40 | 44927 | 14365 | 42562003 |
| HIV associated nephropathy | 13.89 | 11.26 | 7 | 44960 | 347 | 42576021 |
| Seasonal allergy | 13.89 | 11.26 | 28 | 44939 | 8027 | 42568341 |
| Aspiration | 13.87 | 11.26 | 46 | 44921 | 17840 | 42558528 |
| Blood test abnormal | 13.61 | 11.26 | 37 | 44930 | 12869 | 42563499 |
| Hyponatraemia | 13.48 | 11.26 | 165 | 44802 | 101297 | 42475071 |
| Lethargy | 13.35 | 11.26 | 90 | 44877 | 46800 | 42529568 |
| Swelling face | 13.29 | 11.26 | 61 | 44906 | 27493 | 42548875 |
| Dyspnoea paroxysmal nocturnal | 13.10 | 11.26 | 12 | 44955 | 1608 | 42574760 |
| Breath sounds abnormal | 13.08 | 11.26 | 35 | 44932 | 12058 | 42564310 |
| Pancreatitis acute | 12.77 | 11.26 | 10 | 44957 | 33554 | 42542814 |
| Sputum discoloured | 12.70 | 11.26 | 31 | 44936 | 10101 | 42566267 |
| Hypoxic-ischaemic encephalopathy | 12.67 | 11.26 | 21 | 44946 | 5181 | 42571187 |
| Limb mass | 12.63 | 11.26 | 9 | 44958 | 843 | 42575525 |
| Micturition urgency | 12.44 | 11.26 | 34 | 44933 | 11864 | 42564504 |
| Blood phosphorus increased | 12.31 | 11.26 | 35 | 44932 | 12490 | 42563878 |
| Dry skin | 12.14 | 11.26 | 90 | 44877 | 48248 | 42528120 |
| Wheezing | 12.10 | 11.26 | 99 | 44868 | 54682 | 42521686 |
| Cardiovascular disorder | 11.85 | 11.26 | 36 | 44931 | 13329 | 42563039 |
| Ulcer | 11.62 | 11.26 | 41 | 44926 | 16400 | 42559968 |
| Sinus disorder | 11.59 | 11.26 | 26 | 44941 | 8024 | 42568344 |
| Rhinorrhoea | 11.56 | 11.26 | 65 | 44902 | 31729 | 42544639 |
| Accidental exposure to product by child | 11.50 | 11.26 | 11 | 44956 | 1556 | 42574812 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug ineffective | 258.39 | 9.46 | 804 | 117419 | 1519736 | 108951340 |
| Chest discomfort | 119.34 | 9.46 | 433 | 117790 | 173415 | 110297661 |
| Dyspnoea | 117.90 | 9.46 | 1746 | 116477 | 1105126 | 109365950 |
| Neuropathy peripheral | 116.76 | 9.46 | 439 | 117784 | 178838 | 110292238 |
| Delusion of grandeur | 103.92 | 9.46 | 50 | 118173 | 2210 | 110468866 |
| Contraindicated product administered | 99.63 | 9.46 | 72 | 118151 | 248195 | 110222881 |
| Cough | 97.07 | 9.46 | 833 | 117390 | 460808 | 110010268 |
| Treatment failure | 94.60 | 9.46 | 94 | 118129 | 277140 | 110193936 |
| Flushing | 88.73 | 9.46 | 280 | 117943 | 104456 | 110366620 |
| Rhinalgia | 80.54 | 9.46 | 51 | 118172 | 3878 | 110467198 |
| Lymphocyte count abnormal | 77.56 | 9.46 | 42 | 118181 | 2384 | 110468692 |
| Neutropenic sepsis | 69.60 | 9.46 | 121 | 118102 | 30625 | 110440451 |
| Infective pulmonary exacerbation of cystic fibrosis | 68.89 | 9.46 | 82 | 118141 | 14689 | 110456387 |
| Drug intolerance | 67.07 | 9.46 | 217 | 118006 | 406295 | 110064781 |
| Therapeutic product effect decreased | 64.33 | 9.46 | 101 | 118122 | 244215 | 110226861 |
| Asthma | 64.23 | 9.46 | 473 | 117750 | 249818 | 110221258 |
| Synovitis | 62.50 | 9.46 | 124 | 118099 | 273968 | 110197108 |
| Myelosuppression | 61.25 | 9.46 | 13 | 118210 | 94327 | 110376749 |
| Pulmonary embolism | 60.07 | 9.46 | 414 | 117809 | 214060 | 110257016 |
| Drug interaction | 59.84 | 9.46 | 303 | 117920 | 499880 | 109971196 |
| Acute kidney injury | 59.10 | 9.46 | 417 | 117806 | 635013 | 109836063 |
| Off label use | 58.19 | 9.46 | 1194 | 117029 | 1498991 | 108972085 |
| Joint swelling | 54.83 | 9.46 | 265 | 117958 | 442580 | 110028496 |
| Nausea | 54.59 | 9.46 | 1716 | 116507 | 1233974 | 109237102 |
| Therapeutic product effect incomplete | 52.98 | 9.46 | 99 | 118124 | 223706 | 110247370 |
| Sputum increased | 52.73 | 9.46 | 46 | 118177 | 5705 | 110465371 |
| Constipation | 51.93 | 9.46 | 598 | 117625 | 357188 | 110113888 |
| Affective disorder | 51.76 | 9.46 | 62 | 118161 | 11179 | 110459897 |
| Salpingo-oophorectomy unilateral | 49.50 | 9.46 | 22 | 118201 | 809 | 110470267 |
| Lip swelling | 49.06 | 9.46 | 142 | 118081 | 50525 | 110420551 |
| Anaphylactic reaction | 47.70 | 9.46 | 245 | 117978 | 114055 | 110357021 |
| Chest pain | 47.64 | 9.46 | 613 | 117610 | 375762 | 110095314 |
| Anti-cyclic citrullinated peptide antibody positive | 47.17 | 9.46 | 76 | 118147 | 181908 | 110289168 |
| Drug therapy | 47.06 | 9.46 | 48 | 118175 | 7243 | 110463833 |
| Upper respiratory tract infection | 47.04 | 9.46 | 270 | 117953 | 131058 | 110340018 |
| Arthropathy | 46.35 | 9.46 | 155 | 118068 | 287367 | 110183709 |
| Hand deformity | 46.32 | 9.46 | 103 | 118120 | 218403 | 110252673 |
| Neuralgia | 46.11 | 9.46 | 135 | 118088 | 48343 | 110422733 |
| Analgesic therapy | 45.29 | 9.46 | 47 | 118176 | 7237 | 110463839 |
| Sinusitis fungal | 45.28 | 9.46 | 31 | 118192 | 2689 | 110468387 |
| Maternal exposure during pregnancy | 44.89 | 9.46 | 132 | 118091 | 254751 | 110216325 |
| Sleep disorder therapy | 44.30 | 9.46 | 47 | 118176 | 7424 | 110463652 |
| Swelling face | 43.59 | 9.46 | 205 | 118018 | 92116 | 110378960 |
| Back pain | 42.71 | 9.46 | 594 | 117629 | 370402 | 110100674 |
| Rheumatoid arthritis | 42.71 | 9.46 | 170 | 118053 | 299443 | 110171633 |
| Lactic acidosis | 42.62 | 9.46 | 23 | 118200 | 92788 | 110378288 |
| Chronic obstructive pulmonary disease | 41.46 | 9.46 | 228 | 117995 | 108930 | 110362146 |
| Cellulitis | 41.22 | 9.46 | 253 | 117970 | 125763 | 110345313 |
| Nasal congestion | 40.54 | 9.46 | 210 | 118013 | 98072 | 110373004 |
| Pericarditis | 38.20 | 9.46 | 114 | 118109 | 219000 | 110252076 |
| Hyperlipidaemia | 38.17 | 9.46 | 104 | 118119 | 35744 | 110435332 |
| Pemphigus | 37.87 | 9.46 | 111 | 118112 | 214459 | 110256617 |
| Anticoagulant therapy | 37.74 | 9.46 | 37 | 118186 | 5324 | 110465752 |
| Bronchospasm | 37.62 | 9.46 | 93 | 118130 | 30146 | 110440930 |
| Drug ineffective for unapproved indication | 37.25 | 9.46 | 33 | 118190 | 102805 | 110368271 |
| Antacid therapy | 37.03 | 9.46 | 37 | 118186 | 5447 | 110465629 |
| Anxiety | 36.72 | 9.46 | 545 | 117678 | 344533 | 110126543 |
| Hyperphosphataemia | 36.47 | 9.46 | 64 | 118159 | 16317 | 110454759 |
| Hepatic enzyme increased | 36.31 | 9.46 | 198 | 118025 | 320694 | 110150382 |
| Deep vein thrombosis | 36.22 | 9.46 | 265 | 117958 | 139622 | 110331454 |
| Completed suicide | 36.16 | 9.46 | 135 | 118088 | 242246 | 110228830 |
| Diarrhoea | 35.48 | 9.46 | 1522 | 116701 | 1137983 | 109333093 |
| Ejection fraction decreased | 35.26 | 9.46 | 110 | 118113 | 40770 | 110430306 |
| Excessive eye blinking | 35.19 | 9.46 | 23 | 118200 | 1847 | 110469229 |
| Glossodynia | 34.87 | 9.46 | 121 | 118102 | 221883 | 110249193 |
| Drug resistance | 34.16 | 9.46 | 9 | 118214 | 56365 | 110414711 |
| C-reactive protein increased | 34.08 | 9.46 | 119 | 118104 | 217800 | 110253276 |
| Hyperkalaemia | 33.99 | 9.46 | 58 | 118165 | 135738 | 110335338 |
| Nasal discomfort | 33.35 | 9.46 | 37 | 118186 | 6144 | 110464932 |
| Renal failure | 32.63 | 9.46 | 128 | 118095 | 226446 | 110244630 |
| Neutropenia | 32.51 | 9.46 | 572 | 117651 | 374048 | 110097028 |
| Sleep apnoea syndrome | 32.31 | 9.46 | 106 | 118117 | 40341 | 110430735 |
| Palpitations | 32.18 | 9.46 | 285 | 117938 | 158927 | 110312149 |
| Sinusitis | 32.12 | 9.46 | 470 | 117753 | 296218 | 110174858 |
| Pneumonia | 31.89 | 9.46 | 1191 | 117032 | 875523 | 109595553 |
| SARS-CoV-2 test positive | 31.21 | 9.46 | 61 | 118162 | 16874 | 110454202 |
| Lower respiratory tract infection | 31.17 | 9.46 | 397 | 117826 | 242709 | 110228367 |
| Systemic lupus erythematosus | 30.98 | 9.46 | 153 | 118070 | 254185 | 110216891 |
| Lacrimation increased | 30.21 | 9.46 | 87 | 118136 | 30863 | 110440213 |
| Neutropenic infection | 29.84 | 9.46 | 26 | 118197 | 3219 | 110467857 |
| Listless | 29.64 | 9.46 | 30 | 118193 | 4485 | 110466591 |
| Lethargy | 29.43 | 9.46 | 186 | 118037 | 93390 | 110377686 |
| Oxygen saturation decreased | 29.18 | 9.46 | 276 | 117947 | 156706 | 110314370 |
| Throat tightness | 28.78 | 9.46 | 90 | 118133 | 33399 | 110437677 |
| Pyrexia | 28.40 | 9.46 | 1202 | 117021 | 897063 | 109574013 |
| Sopor | 28.37 | 9.46 | 3 | 118220 | 36543 | 110434533 |
| Oropharyngeal pain | 28.29 | 9.46 | 244 | 117979 | 135032 | 110336044 |
| General physical health deterioration | 27.99 | 9.46 | 305 | 117918 | 424990 | 110046086 |
| Duodenal ulcer perforation | 27.81 | 9.46 | 97 | 118126 | 177603 | 110293473 |
| Mucosal inflammation | 27.74 | 9.46 | 187 | 118036 | 95954 | 110375122 |
| Emotional distress | 27.67 | 9.46 | 108 | 118115 | 44739 | 110426337 |
| Fatigue | 27.58 | 9.46 | 1575 | 116648 | 1214383 | 109256693 |
| Incorrect dose administered | 26.63 | 9.46 | 196 | 118027 | 103445 | 110367631 |
| Congenital hiatus hernia | 26.35 | 9.46 | 33 | 118190 | 6226 | 110464850 |
| Eosinophilic colitis | 25.91 | 9.46 | 13 | 118210 | 630 | 110470446 |
| Myasthenia gravis | 25.54 | 9.46 | 65 | 118158 | 21446 | 110449630 |
| Interstitial lung disease | 25.37 | 9.46 | 71 | 118152 | 139263 | 110331813 |
| Respiratory symptom | 25.35 | 9.46 | 52 | 118171 | 14893 | 110456183 |
| Hypoacusis | 25.27 | 9.46 | 89 | 118134 | 35102 | 110435974 |
| Blood pressure fluctuation | 24.78 | 9.46 | 26 | 118197 | 74798 | 110396278 |
| Helicobacter infection | 24.77 | 9.46 | 105 | 118118 | 181772 | 110289304 |
| Arthralgia | 24.32 | 9.46 | 641 | 117582 | 778991 | 109692085 |
| Gout | 24.16 | 9.46 | 90 | 118133 | 36476 | 110434600 |
| Stress | 24.15 | 9.46 | 194 | 118029 | 105154 | 110365922 |
| Rheumatoid factor positive | 24.03 | 9.46 | 67 | 118156 | 131573 | 110339503 |
| Hypophosphataemia | 23.90 | 9.46 | 84 | 118139 | 33098 | 110437978 |
| Plethoric face | 23.86 | 9.46 | 6 | 118217 | 33 | 110471043 |
| Therapy non-responder | 23.86 | 9.46 | 87 | 118136 | 157220 | 110313856 |
| Condition aggravated | 23.76 | 9.46 | 601 | 117622 | 734235 | 109736841 |
| Vulvovaginal candidiasis | 23.74 | 9.46 | 23 | 118200 | 3262 | 110467814 |
| Neuroleptic malignant syndrome | 23.58 | 9.46 | 4 | 118219 | 34055 | 110437021 |
| Urticaria | 23.56 | 9.46 | 475 | 117748 | 318382 | 110152694 |
| Febrile neutropenia | 23.44 | 9.46 | 472 | 117751 | 316295 | 110154781 |
| Urinary tract infection | 23.10 | 9.46 | 483 | 117740 | 325799 | 110145277 |
| Malignant neoplasm progression | 23.03 | 9.46 | 102 | 118121 | 174465 | 110296611 |
| Coma | 23.02 | 9.46 | 58 | 118165 | 117811 | 110353265 |
| Chest injury | 23.02 | 9.46 | 23 | 118200 | 3386 | 110467690 |
| Nail infection | 23.01 | 9.46 | 20 | 118203 | 2468 | 110468608 |
| Rhinorrhoea | 22.96 | 9.46 | 188 | 118035 | 102478 | 110368598 |
| Schizophrenia | 22.92 | 9.46 | 63 | 118160 | 21763 | 110449313 |
| Product use issue | 22.77 | 9.46 | 218 | 118005 | 311477 | 110159599 |
| Feeling hot | 22.67 | 9.46 | 171 | 118052 | 90935 | 110380141 |
| Hiatus hernia | 22.63 | 9.46 | 73 | 118150 | 27533 | 110443543 |
| Dilatation intrahepatic duct acquired | 22.60 | 9.46 | 13 | 118210 | 830 | 110470246 |
| Gallbladder polyp | 22.21 | 9.46 | 15 | 118208 | 1272 | 110469804 |
| Mood swings | 22.14 | 9.46 | 64 | 118159 | 22748 | 110448328 |
| Band sensation | 22.11 | 9.46 | 14 | 118209 | 1064 | 110470012 |
| Hypersomnia | 21.93 | 9.46 | 73 | 118150 | 27988 | 110443088 |
| Feeling cold | 21.91 | 9.46 | 83 | 118140 | 33904 | 110437172 |
| Erythema | 21.81 | 9.46 | 435 | 117788 | 291012 | 110180064 |
| Reduced facial expression | 21.70 | 9.46 | 23 | 118200 | 3628 | 110467448 |
| Myalgia | 21.63 | 9.46 | 346 | 117877 | 222035 | 110249041 |
| Headache | 21.54 | 9.46 | 1151 | 117072 | 881226 | 109589850 |
| Renal impairment | 21.46 | 9.46 | 116 | 118107 | 188329 | 110282747 |
| Tachycardia | 21.44 | 9.46 | 351 | 117872 | 226294 | 110244782 |
| Catheter site bruise | 21.06 | 9.46 | 11 | 118212 | 580 | 110470496 |
| Diastolic dysfunction | 20.85 | 9.46 | 43 | 118180 | 12361 | 110458715 |
| Toxicity to various agents | 20.77 | 9.46 | 375 | 117848 | 480180 | 109990896 |
| Infusion site erythema | 20.74 | 9.46 | 42 | 118181 | 11917 | 110459159 |
| Appendicitis | 20.45 | 9.46 | 72 | 118151 | 28392 | 110442684 |
| Coronary artery disease | 20.41 | 9.46 | 139 | 118084 | 71551 | 110399525 |
| Embolism venous | 20.38 | 9.46 | 26 | 118197 | 4997 | 110466079 |
| Necrotic lymphadenopathy | 20.38 | 9.46 | 8 | 118215 | 214 | 110470862 |
| Hypoxia | 20.36 | 9.46 | 220 | 118003 | 129295 | 110341781 |
| Blood calcium increased | 19.87 | 9.46 | 53 | 118170 | 17987 | 110453089 |
| Agranulocytosis | 19.85 | 9.46 | 22 | 118201 | 61738 | 110409338 |
| Foreign body | 19.84 | 9.46 | 20 | 118203 | 2975 | 110468101 |
| Bradycardia | 19.84 | 9.46 | 92 | 118131 | 155425 | 110315651 |
| Failure to anastomose | 19.71 | 9.46 | 8 | 118215 | 234 | 110470842 |
| Sinus tachycardia | 19.70 | 9.46 | 97 | 118126 | 44396 | 110426680 |
| Seizure | 19.62 | 9.46 | 339 | 117884 | 220846 | 110250230 |
| Toxic skin eruption | 19.57 | 9.46 | 3 | 118220 | 27512 | 110443564 |
| Painful respiration | 19.48 | 9.46 | 22 | 118201 | 3725 | 110467351 |
| Rhinitis allergic | 19.08 | 9.46 | 52 | 118171 | 17870 | 110453206 |
| Abdominal discomfort | 19.08 | 9.46 | 301 | 117922 | 393557 | 110077519 |
| Product dose omission issue | 18.91 | 9.46 | 464 | 117759 | 321318 | 110149758 |
| Bronchopulmonary aspergillosis allergic | 18.86 | 9.46 | 33 | 118190 | 8393 | 110462683 |
| Transient ischaemic attack | 18.78 | 9.46 | 125 | 118098 | 63857 | 110407219 |
| Cholestasis | 18.61 | 9.46 | 25 | 118198 | 64493 | 110406583 |
| Eosinophilia | 18.23 | 9.46 | 21 | 118202 | 57915 | 110413161 |
| C-reactive protein abnormal | 18.20 | 9.46 | 74 | 118149 | 129621 | 110341455 |
| Oedema peripheral | 18.16 | 9.46 | 470 | 117753 | 328190 | 110142886 |
| Acute sinusitis | 18.11 | 9.46 | 25 | 118198 | 5186 | 110465890 |
| Hyperhidrosis | 18.06 | 9.46 | 291 | 117932 | 187007 | 110284069 |
| Rhabdomyolysis | 17.99 | 9.46 | 67 | 118156 | 120334 | 110350742 |
| Confusional arousal | 17.98 | 9.46 | 7 | 118216 | 183 | 110470893 |
| Blood pressure diastolic abnormal | 17.94 | 9.46 | 3 | 118220 | 25812 | 110445264 |
| Wound | 17.53 | 9.46 | 163 | 118060 | 234274 | 110236802 |
| Gastroenteritis viral | 17.51 | 9.46 | 73 | 118150 | 31153 | 110439923 |
| Haemorrhoids | 17.42 | 9.46 | 80 | 118143 | 35592 | 110435484 |
| Nasal turbinate hypertrophy | 17.41 | 9.46 | 11 | 118212 | 833 | 110470243 |
| Red blood cell sedimentation rate increased | 17.34 | 9.46 | 36 | 118187 | 78266 | 110392810 |
| Activated partial thromboplastin time prolonged | 17.31 | 9.46 | 58 | 118165 | 22310 | 110448766 |
| Bicuspid aortic valve | 17.27 | 9.46 | 5 | 118218 | 50 | 110471026 |
| Chemical burns of eye | 17.20 | 9.46 | 6 | 118217 | 114 | 110470962 |
| Hysterectomy | 17.16 | 9.46 | 31 | 118192 | 8083 | 110462993 |
| Rhinitis | 17.04 | 9.46 | 58 | 118165 | 22487 | 110448589 |
| Blood phosphorus increased | 16.99 | 9.46 | 47 | 118176 | 16293 | 110454783 |
| Cardiac failure | 16.97 | 9.46 | 124 | 118099 | 187502 | 110283574 |
| Poor quality device used | 16.95 | 9.46 | 18 | 118205 | 2845 | 110468231 |
| Pancytopenia | 16.88 | 9.46 | 143 | 118080 | 209470 | 110261606 |
| Sinus headache | 16.70 | 9.46 | 26 | 118197 | 6006 | 110465070 |
| Bronchitis | 16.68 | 9.46 | 248 | 117975 | 156784 | 110314292 |
| Diverticulum | 16.48 | 9.46 | 45 | 118178 | 15481 | 110455595 |
| Hot flush | 16.46 | 9.46 | 124 | 118099 | 65912 | 110405164 |
| Pleuritic pain | 16.37 | 9.46 | 46 | 118177 | 16094 | 110454982 |
| Dizziness | 16.27 | 9.46 | 907 | 117316 | 697286 | 109773790 |
| Polyglandular disorder | 16.23 | 9.46 | 7 | 118216 | 239 | 110470837 |
| COVID-19 | 16.13 | 9.46 | 359 | 117864 | 244701 | 110226375 |
| Blood pressure systolic increased | 16.08 | 9.46 | 41 | 118182 | 82950 | 110388126 |
| Inflammation | 15.93 | 9.46 | 131 | 118092 | 193107 | 110277969 |
| Bronchopulmonary aspergillosis | 15.90 | 9.46 | 6 | 118217 | 29857 | 110441219 |
| Wheezing | 15.89 | 9.46 | 371 | 117852 | 254859 | 110216217 |
| Acute respiratory failure | 15.86 | 9.46 | 136 | 118087 | 75124 | 110395952 |
| Therapy partial responder | 15.86 | 9.46 | 10 | 118213 | 37051 | 110434025 |
| Appendicolith | 15.82 | 9.46 | 42 | 118181 | 14213 | 110456863 |
| Vertigo | 15.77 | 9.46 | 152 | 118071 | 86718 | 110384358 |
| Discomfort | 15.75 | 9.46 | 150 | 118073 | 214557 | 110256519 |
| Haemophagocytic lymphohistiocytosis | 15.73 | 9.46 | 7 | 118216 | 31552 | 110439524 |
| Product prescribing error | 15.73 | 9.46 | 19 | 118204 | 51312 | 110419764 |
| Hip arthroplasty | 15.72 | 9.46 | 22 | 118201 | 55791 | 110415285 |
| Tubulointerstitial nephritis | 15.69 | 9.46 | 21 | 118202 | 54263 | 110416813 |
| Troponin increased | 15.47 | 9.46 | 68 | 118155 | 29698 | 110441378 |
| Biliary sepsis | 15.42 | 9.46 | 14 | 118209 | 1829 | 110469247 |
| Shock haemorrhagic | 15.32 | 9.46 | 5 | 118218 | 27242 | 110443834 |
| Apathy | 15.23 | 9.46 | 45 | 118178 | 16194 | 110454882 |
| Dyspnoea exertional | 15.10 | 9.46 | 174 | 118049 | 103886 | 110367190 |
| Impaired healing | 15.04 | 9.46 | 136 | 118087 | 196581 | 110274495 |
| Sinus disorder | 14.95 | 9.46 | 72 | 118151 | 32656 | 110438420 |
| Premature delivery | 14.95 | 9.46 | 7 | 118216 | 30625 | 110440451 |
| Tonsillar hypertrophy | 14.82 | 9.46 | 14 | 118209 | 1924 | 110469152 |
| Psoriatic arthropathy | 14.63 | 9.46 | 137 | 118086 | 196624 | 110274452 |
| Polyneuropathy | 14.60 | 9.46 | 8 | 118215 | 32004 | 110439072 |
| Head discomfort | 14.47 | 9.46 | 49 | 118174 | 18951 | 110452125 |
| Chills | 14.43 | 9.46 | 285 | 117938 | 190295 | 110280781 |
| Retching | 14.30 | 9.46 | 55 | 118168 | 22627 | 110448449 |
| Vision blurred | 14.18 | 9.46 | 205 | 118018 | 128817 | 110342259 |
| Epilepsy | 14.17 | 9.46 | 57 | 118166 | 100152 | 110370924 |
| Rash macular | 14.15 | 9.46 | 80 | 118143 | 38606 | 110432470 |
| Iron deficiency anaemia | 14.11 | 9.46 | 69 | 118154 | 31490 | 110439586 |
| Cystic fibrosis | 13.96 | 9.46 | 21 | 118202 | 4710 | 110466366 |
| Biliary dyskinesia | 13.95 | 9.46 | 15 | 118208 | 2406 | 110468670 |
| Suffocation feeling | 13.92 | 9.46 | 14 | 118209 | 2077 | 110468999 |
| Nephropathy toxic | 13.85 | 9.46 | 6 | 118217 | 27472 | 110443604 |
| Pulmonary fibrosis | 13.84 | 9.46 | 59 | 118164 | 101983 | 110369093 |
| Mobility decreased | 13.77 | 9.46 | 175 | 118048 | 237247 | 110233829 |
| Cholecystitis chronic | 13.75 | 9.46 | 31 | 118192 | 9469 | 110461607 |
| Bronchial neoplasm | 13.66 | 9.46 | 8 | 118215 | 528 | 110470548 |
| HIV associated nephropathy | 13.65 | 9.46 | 7 | 118216 | 355 | 110470721 |
| Blister infected | 13.57 | 9.46 | 11 | 118212 | 1233 | 110469843 |
| Intentional self-injury | 13.56 | 9.46 | 12 | 118211 | 37417 | 110433659 |
| Dyspnoea paroxysmal nocturnal | 13.54 | 9.46 | 15 | 118208 | 2487 | 110468589 |
| Pancreatitis chronic | 13.43 | 9.46 | 20 | 118203 | 4445 | 110466631 |
| Seasonal allergy | 13.41 | 9.46 | 49 | 118174 | 19673 | 110451403 |
| Intentional product misuse | 13.38 | 9.46 | 208 | 118015 | 132696 | 110338380 |
| Periorbital oedema | 13.37 | 9.46 | 32 | 118191 | 10160 | 110460916 |
| Bone pain | 13.36 | 9.46 | 117 | 118106 | 65016 | 110406060 |
| Vascular compression | 13.23 | 9.46 | 9 | 118214 | 772 | 110470304 |
| Altered state of consciousness | 13.18 | 9.46 | 26 | 118197 | 57600 | 110413476 |
| Musculoskeletal stiffness | 13.16 | 9.46 | 215 | 118008 | 279607 | 110191469 |
| Micturition urgency | 13.14 | 9.46 | 48 | 118175 | 19272 | 110451804 |
| Candida infection | 13.03 | 9.46 | 92 | 118131 | 47917 | 110423159 |
| Inappropriate schedule of product administration | 12.99 | 9.46 | 147 | 118076 | 203490 | 110267586 |
| Transplant rejection | 12.97 | 9.46 | 5 | 118218 | 24562 | 110446514 |
| Bacterial infection | 12.95 | 9.46 | 89 | 118134 | 45947 | 110425129 |
| Multi-organ disorder | 12.94 | 9.46 | 17 | 118206 | 3364 | 110467712 |
| Poor peripheral circulation | 12.91 | 9.46 | 19 | 118204 | 4178 | 110466898 |
| Neutrophil count increased | 12.90 | 9.46 | 72 | 118151 | 34580 | 110436496 |
| Presyncope | 12.87 | 9.46 | 93 | 118130 | 48794 | 110422282 |
| Pelvic infection | 12.77 | 9.46 | 7 | 118216 | 407 | 110470669 |
| Muscle injury | 12.76 | 9.46 | 93 | 118130 | 140714 | 110330362 |
| Hallucination, auditory | 12.74 | 9.46 | 59 | 118164 | 26338 | 110444738 |
| Loss of personal independence in daily activities | 12.69 | 9.46 | 101 | 118122 | 149919 | 110321157 |
| Blood uric acid increased | 12.60 | 9.46 | 51 | 118172 | 21478 | 110449598 |
| Tremor | 12.60 | 9.46 | 294 | 117929 | 201938 | 110269138 |
| Gastrooesophageal reflux disease | 12.59 | 9.46 | 266 | 117957 | 179710 | 110291366 |
| Umbilical hernia | 12.59 | 9.46 | 25 | 118198 | 6997 | 110464079 |
| Blood pressure diastolic decreased | 12.42 | 9.46 | 12 | 118211 | 35873 | 110435203 |
| Drug tolerance decreased | 12.39 | 9.46 | 7 | 118216 | 27533 | 110443543 |
| Liver injury | 12.38 | 9.46 | 102 | 118121 | 150311 | 110320765 |
| Delusion of replacement | 12.37 | 9.46 | 6 | 118217 | 270 | 110470806 |
| Therapeutic response decreased | 12.36 | 9.46 | 57 | 118166 | 96442 | 110374634 |
| Oral candidiasis | 12.28 | 9.46 | 86 | 118137 | 44674 | 110426402 |
| Creatinine renal clearance decreased | 12.27 | 9.46 | 4 | 118219 | 21811 | 110449265 |
| Ureteric haemorrhage | 12.26 | 9.46 | 5 | 118218 | 148 | 110470928 |
| Tympanic membrane hyperaemia | 12.17 | 9.46 | 3 | 118220 | 15 | 110471061 |
| Peripheral pulse decreased | 12.16 | 9.46 | 4 | 118219 | 63 | 110471013 |
| Benign prostatic hyperplasia | 12.14 | 9.46 | 45 | 118178 | 18189 | 110452887 |
| Rheumatic fever | 12.07 | 9.46 | 79 | 118144 | 122500 | 110348576 |
| Failure of child resistant product closure | 11.93 | 9.46 | 4 | 118219 | 67 | 110471009 |
| Vomiting | 11.90 | 9.46 | 1129 | 117094 | 909546 | 109561530 |
| Cyanosis | 11.88 | 9.46 | 63 | 118160 | 29678 | 110441398 |
| Hypervolaemia | 11.84 | 9.46 | 92 | 118131 | 49368 | 110421708 |
| Nasal polyps | 11.83 | 9.46 | 36 | 118187 | 13164 | 110457912 |
| Adverse event | 11.83 | 9.46 | 68 | 118155 | 108741 | 110362335 |
| Intentional product use issue | 11.82 | 9.46 | 190 | 118033 | 247716 | 110223360 |
| Grip strength decreased | 11.72 | 9.46 | 45 | 118178 | 80129 | 110390947 |
| Emphysema | 11.72 | 9.46 | 47 | 118176 | 19709 | 110451367 |
| Vestibular neuronitis | 11.63 | 9.46 | 9 | 118214 | 944 | 110470132 |
| Nail dystrophy | 11.62 | 9.46 | 10 | 118213 | 1218 | 110469858 |
| Retinal detachment | 11.61 | 9.46 | 32 | 118191 | 11068 | 110460008 |
| Pain in jaw | 11.59 | 9.46 | 94 | 118129 | 51083 | 110419993 |
| Otitis media | 11.50 | 9.46 | 25 | 118198 | 7451 | 110463625 |
| Drug reaction with eosinophilia and systemic symptoms | 11.42 | 9.46 | 47 | 118176 | 82048 | 110389028 |
| Laryngospasm | 11.39 | 9.46 | 19 | 118204 | 4649 | 110466427 |
| Hyperpyrexia | 11.31 | 9.46 | 26 | 118197 | 8043 | 110463033 |
| Abnormal behaviour | 11.30 | 9.46 | 76 | 118147 | 38963 | 110432113 |
| Death | 11.18 | 9.46 | 622 | 117601 | 698247 | 109772829 |
| Knee arthroplasty | 11.16 | 9.46 | 34 | 118189 | 64914 | 110406162 |
| Nasal herpes | 11.08 | 9.46 | 8 | 118215 | 755 | 110470321 |
| Iron deficiency | 11.00 | 9.46 | 44 | 118179 | 18432 | 110452644 |
| Posterior reversible encephalopathy syndrome | 10.95 | 9.46 | 12 | 118211 | 33849 | 110437227 |
| Diverticulitis | 10.90 | 9.46 | 96 | 118127 | 53426 | 110417650 |
| Pulmonary alveolar haemorrhage | 10.81 | 9.46 | 4 | 118219 | 20146 | 110450930 |
| Haemodialysis complication | 10.73 | 9.46 | 6 | 118217 | 363 | 110470713 |
| Folliculitis | 10.71 | 9.46 | 121 | 118102 | 167532 | 110303544 |
| Intentional product misuse to child | 10.70 | 9.46 | 5 | 118218 | 207 | 110470869 |
| Essential hypertension | 10.69 | 9.46 | 25 | 118198 | 7822 | 110463254 |
| Swollen tongue | 10.66 | 9.46 | 105 | 118118 | 60257 | 110410819 |
| Accidental exposure to product by child | 10.60 | 9.46 | 15 | 118208 | 3183 | 110467893 |
| Prosopagnosia | 10.60 | 9.46 | 4 | 118219 | 96 | 110470980 |
| Prescribed underdose | 10.58 | 9.46 | 35 | 118188 | 65139 | 110405937 |
| Bronchial haemorrhage | 10.57 | 9.46 | 10 | 118213 | 1377 | 110469699 |
| Bone erosion | 10.54 | 9.46 | 21 | 118202 | 46350 | 110424726 |
| Infusion site mass | 10.47 | 9.46 | 11 | 118212 | 1717 | 110469359 |
| Infusion site pruritus | 10.42 | 9.46 | 19 | 118204 | 4989 | 110466087 |
| Irritability | 10.39 | 9.46 | 87 | 118136 | 47722 | 110423354 |
| Cystic fibrosis related diabetes | 10.37 | 9.46 | 5 | 118218 | 222 | 110470854 |
| Sepsis | 10.29 | 9.46 | 438 | 117785 | 326908 | 110144168 |
| Blister | 10.27 | 9.46 | 176 | 118047 | 227200 | 110243876 |
| Exposure during pregnancy | 10.24 | 9.46 | 122 | 118101 | 167302 | 110303774 |
| Gait disturbance | 10.22 | 9.46 | 223 | 118000 | 277985 | 110193091 |
| Product quality issue | 10.22 | 9.46 | 127 | 118096 | 77172 | 110393904 |
| Therapy interrupted | 10.13 | 9.46 | 24 | 118199 | 49798 | 110421278 |
| Optic disc drusen | 10.11 | 9.46 | 3 | 118220 | 33 | 110471043 |
| International normalised ratio increased | 10.10 | 9.46 | 53 | 118170 | 86719 | 110384357 |
| Victim of chemical submission | 10.07 | 9.46 | 8 | 118215 | 871 | 110470205 |
| Panic attack | 10.03 | 9.46 | 59 | 118164 | 28881 | 110442195 |
| Faeces hard | 9.99 | 9.46 | 17 | 118206 | 4229 | 110466847 |
| Abnormal sensation in eye | 9.97 | 9.46 | 12 | 118211 | 2174 | 110468902 |
| Septic shock | 9.94 | 9.46 | 114 | 118109 | 157414 | 110313662 |
| Infusion site swelling | 9.87 | 9.46 | 28 | 118195 | 9849 | 110461227 |
| Aplastic anaemia | 9.81 | 9.46 | 7 | 118216 | 24301 | 110446775 |
| Thrombotic microangiopathy | 9.80 | 9.46 | 10 | 118213 | 29139 | 110441937 |
| Reading disorder | 9.78 | 9.46 | 9 | 118214 | 1196 | 110469880 |
| Ventricular extrasystoles | 9.77 | 9.46 | 49 | 118174 | 22592 | 110448484 |
| Oropharyngeal blistering | 9.73 | 9.46 | 8 | 118215 | 915 | 110470161 |
| Pulmonary hypertension | 9.72 | 9.46 | 96 | 118127 | 55124 | 110415952 |
| Obstructive defaecation | 9.69 | 9.46 | 5 | 118218 | 257 | 110470819 |
| Deafness permanent | 9.67 | 9.46 | 8 | 118215 | 923 | 110470153 |
| Joint stiffness | 9.67 | 9.46 | 38 | 118185 | 67205 | 110403871 |
| Acute hepatic failure | 9.66 | 9.46 | 15 | 118208 | 36453 | 110434623 |
| Posterior tibial nerve injury | 9.65 | 9.46 | 3 | 118220 | 39 | 110471037 |
| Hiccups | 9.63 | 9.46 | 33 | 118190 | 12836 | 110458240 |
| Endometrial ablation | 9.54 | 9.46 | 8 | 118215 | 940 | 110470136 |
| Irritable bowel syndrome | 9.54 | 9.46 | 121 | 118102 | 164094 | 110306982 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R06AB04 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Substituted alkylamines |
| ATC | R06AB54 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Substituted alkylamines |
| FDA MoA | N0000000190 | Histamine H1 Receptor Antagonists |
| CHEBI has role | CHEBI:35480 | analgesic |
| CHEBI has role | CHEBI:51177 | antitussive |
| CHEBI has role | CHEBI:77715 | nasal decongestant |
| MeSH PA | D000982 | Antipruritics |
| MeSH PA | D003879 | Dermatologic Agents |
| MeSH PA | D006633 | Histamine Antagonists |
| MeSH PA | D006634 | Histamine H1 Antagonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018926 | Anti-Allergic Agents |
| FDA EPC | N0000175587 | Histamine-1 Receptor Antagonist |
| CHEBI has role | CHEBI:35469 | antidepressant |
| CHEBI has role | CHEBI:37955 | H<small><sub>1</sub></small>-receptor antagonist |
| CHEBI has role | CHEBI:37956 | histamine antagonist |
| CHEBI has role | CHEBI:50857 | anti-allergic agent |
| CHEBI has role | CHEBI:50949 | serotonin uptake inhibitor |
| CHEBI has role | CHEBI:59683 | antipruritic drug |
| CHEBI has role | CHEBI:22587 | antiviral agent |
| CHEBI has role | CHEBI:64951 | anti-HBV agent |
Related Drugs by ATC class:
R06AB Substituted alkylamines 6 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Dermatographic urticaria | indication | 7632005 | DOID:743 |
| Vasomotor rhinitis | indication | 8229003 | DOID:4730 |
| Allergic rhinitis | indication | 61582004 | |
| Nasal discharge | indication | 64531003 | |
| Nasal congestion | indication | 68235000 | |
| Sneezing | indication | 76067001 | |
| Common cold | indication | 82272006 | DOID:10459 |
| Urticaria | indication | 126485001 | |
| Influenza-like symptoms | indication | 315642008 | |
| Seasonal allergic rhinitis | indication | 367498001 | |
| Itching of skin | indication | 418363000 | |
| Allergic conjunctivitis | indication | 473460002 | DOID:11204 |
| Brain damage | contraindication | 2470005 | |
| Necrotizing enterocolitis in fetus OR newborn | contraindication | 2707005 | |
| Goiter | contraindication | 3716002 | DOID:12176 |
| Ocular hypertension | contraindication | 4210003 | DOID:9282 |
| Gastritis | contraindication | 4556007 | DOID:4029 |
| Tachyarrhythmia | contraindication | 6285003 | |
| Suicidal thoughts | contraindication | 6471006 | |
| Dependent drug abuse | contraindication | 6525002 | |
| Urinary tract obstruction | contraindication | 7163005 | DOID:5200 |
| Alcoholism | contraindication | 7200002 | |
| Alcohol withdrawal delirium | contraindication | 8635005 | |
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
| Asthenia | contraindication | 13791008 | |
| Hyperkalemia | contraindication | 14140009 | |
| Severe chronic ulcerative colitis | contraindication | 14311001 | |
| Constipation | contraindication | 14760008 | DOID:2089 |
| Disorder of autonomic nervous system | contraindication | 15241006 | |
| Chronic disease of respiratory system | contraindication | 17097001 | |
| Mood swings | contraindication | 18963009 | |
| Hashimoto thyroiditis | contraindication | 21983002 | |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Glaucoma | contraindication | 23986001 | DOID:1686 |
| Inflammatory bowel disease | contraindication | 24526004 | DOID:0050589 |
| Ventricular tachycardia | contraindication | 25569003 | |
| Acute tuberculosis | contraindication | 25629007 | |
| Alcohol intoxication | contraindication | 25702006 | |
| Shock | contraindication | 27942005 | |
| Toxic megacolon | contraindication | 28536002 | DOID:1770 |
| Atony of colon | contraindication | 29479008 | |
| Hypercapnia | contraindication | 29596007 | |
| Bronchitis | contraindication | 32398004 | DOID:6132 |
| Dehydration | contraindication | 34095006 | |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Acute hepatitis | contraindication | 37871000 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Hypovolemic shock | contraindication | 39419009 | |
| Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
| Gastrointestinal ulcer | contraindication | 40845000 | |
| Hypothyroidism | contraindication | 40930008 | DOID:1459 |
| Complete trisomy 21 syndrome | contraindication | 41040004 | DOID:14250 |
| Body fluid retention | contraindication | 43498006 | |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Low blood pressure | contraindication | 45007003 | |
| Achalasia of esophagus | contraindication | 45564002 | DOID:9164 |
| Chronic heart failure | contraindication | 48447003 | |
| Bradycardia | contraindication | 48867003 | |
| Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
| Acidosis | contraindication | 51387008 | |
| Gastrointestinal perforation | contraindication | 51875005 | |
| Vitamin K deficiency | contraindication | 52675005 | DOID:11249 |
| Nasal polyp | contraindication | 52756005 | |
| Coronary arteriosclerosis | contraindication | 53741008 | DOID:3393 |
| Paralytic ileus | contraindication | 55525008 | DOID:8442 |
| Peptic reflux disease | contraindication | 57643001 | |
| Acute nephropathy | contraindication | 58574008 | |
| Hepatic failure | contraindication | 59927004 | |
| Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Arterial thrombosis | contraindication | 65198009 | |
| Drug AND/OR toxin-induced diarrhea | contraindication | 65979008 | |
| Substance abuse | contraindication | 66214007 | |
| Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
| Psychotic disorder | contraindication | 69322001 | |
| Poisoning by acetaminophen | contraindication | 70273001 | |
| Agoraphobia | contraindication | 70691001 | DOID:593 |
| Arteriosclerotic vascular disease | contraindication | 72092001 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Factor II deficiency | contraindication | 73975000 | |
| Reye's syndrome | contraindication | 74351001 | DOID:14525 |
| Gastrointestinal hemorrhage | contraindication | 74474003 | |
| Urethral stricture | contraindication | 76618002 | |
| Thrombotic thrombocytopenic purpura | contraindication | 78129009 | DOID:10772 |
| Spastic paralysis | contraindication | 78403003 | |
| Disturbance of salivary secretion | contraindication | 78948009 | |
| Decreased respiratory function | contraindication | 80954004 | |
| Injury of head | contraindication | 82271004 | |
| Chronic idiopathic constipation | contraindication | 82934008 | |
| Cor pulmonale | contraindication | 83291003 | DOID:8515 |
| Hiatal hernia | contraindication | 84089009 | DOID:12642 |
| Epilepsy | contraindication | 84757009 | DOID:1826 |
| Pulmonary emphysema | contraindication | 87433001 | |
| Gout | contraindication | 90560007 | DOID:13189 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Thyrotoxicosis | contraindication | 90739004 | DOID:7997 |
| Hemophilia | contraindication | 90935002 | |
| Myasthenia gravis | contraindication | 91637004 | DOID:437 |
| Dermatitis herpetiformis | contraindication | 111196000 | DOID:8505 |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| Acute abdominal pain | contraindication | 116290004 | |
| Procedure on urinary system | contraindication | 118677009 | |
| Gastrointestinal obstruction | contraindication | 126765001 | |
| Neoplasm of brain | contraindication | 126952004 | DOID:1319 |
| von Willebrand disorder | contraindication | 128105004 | DOID:12531 |
| Seizure disorder | contraindication | 128613002 | |
| Autonomic dysreflexia | contraindication | 129618003 | |
| Bleeding | contraindication | 131148009 | |
| Drug-induced psychosis | contraindication | 191483003 | DOID:1742 |
| Obsessive-compulsive disorder | contraindication | 191736004 | DOID:10933 |
| Insomnia | contraindication | 193462001 | |
| Partial atrioventricular block | contraindication | 195039008 | |
| Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
| Impaired renal function disorder | contraindication | 197663003 | |
| Coronary artery bypass graft | contraindication | 232717009 | |
| Myocardial dysfunction | contraindication | 233928007 | |
| Gastroesophageal reflux disease | contraindication | 235595009 | DOID:8534 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Bladder outflow obstruction | contraindication | 236645006 | |
| Morbid obesity | contraindication | 238136002 | DOID:11981 |
| Hypocomplementemic urticarial vasculitis | contraindication | 239945009 | |
| Pyloric obstruction | contraindication | 244815007 | |
| Benign prostatic hyperplasia | contraindication | 266569009 | |
| Retention of urine | contraindication | 267064002 | |
| Anemia | contraindication | 271737000 | DOID:2355 |
| Drowsy | contraindication | 271782001 | |
| Exacerbation of asthma | contraindication | 281239006 | |
| Pregnancy, function | contraindication | 289908002 | |
| Lesion of brain | contraindication | 301766008 | |
| Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
| Panic disorder | contraindication | 371631005 | DOID:594 |
| Coma | contraindication | 371632003 | |
| Primary adrenocortical insufficiency | contraindication | 373662000 | |
| Operation on gastrointestinal tract | contraindication | 386621005 | |
| Hypoxia | contraindication | 389086002 | |
| Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
| Cardiovascular event risk | contraindication | 395112001 | |
| Pseudomembranous enterocolitis | contraindication | 397683000 | |
| Gastric ulcer | contraindication | 397825006 | DOID:10808 |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Chronic lung disease | contraindication | 413839001 | |
| Chronic myocardial ischemia | contraindication | 413844008 | DOID:3393 |
| Disorder of coronary artery | contraindication | 414024009 | |
| Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
| Myocardial infarction in recovery phase | contraindication | 418044006 | |
| Central nervous system depression | contraindication | 418072004 | |
| Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant | contraindication | 422681000 | |
| Fever greater than 100.4 Fahrenheit | contraindication | 426000000 | |
| Dysfunction of sphincter of Oddi | contraindication | 430887001 | |
| Hypertensive urgency | contraindication | 443482000 | |
| Acute erosive gastritis | contraindication | 444926003 | |
| Smokes tobacco daily | contraindication | 449868002 | |
| Acute exacerbation of asthma | contraindication | 708038006 | |
| Acute Thromboembolic Stroke | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.47 | Basic |
| pKa2 | 4.14 | Basic |
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 8MG;54.3MG | TUXARIN ER | MAINPOINTE | N206323 | June 22, 2015 | RX | TABLET, EXTENDED RELEASE | ORAL | 9066942 | Jan. 3, 2032 | TREATMENT OF COUGH AND SYMPTOMS ASSOCIATED WITH UPPER RESPIRATORY ALLERGIES OR A COMMON COLD WITH CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE ORALLY ADMINISTERED EXTENDED RELEASE TABLETS |
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Histamine H1 receptor | GPCR | ANTAGONIST | Ki | 8.15 | WOMBAT-PK | CHEMBL | |||
| Sodium-dependent serotonin transporter | Transporter | Kd | 7.82 | WOMBAT-PK | |||||
| 5-hydroxytryptamine receptor 2B | GPCR | Ki | 5.17 | PDSP | |||||
| Histamine H4 receptor | GPCR | Ki | 6.67 | WOMBAT-PK | |||||
| Cytochrome P450 2D6 | Enzyme | Ki | 4.97 | WOMBAT-PK | |||||
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | IC50 | 5 | CHEMBL | |||||
| Lethal(3)malignant brain tumor-like protein 1 | Nuclear other | IC50 | 4.39 | CHEMBL | |||||
| Lethal(3)malignant brain tumor-like protein 3 | Nuclear other | IC50 | 4.38 | CHEMBL | |||||
| MBT domain-containing protein 1 | Nuclear other | IC50 | 4.47 | CHEMBL | |||||
| Sodium-dependent noradrenaline transporter | Transporter | Kd | 5.84 | SCIENTIFIC LITERATURE | |||||
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.96 | CHEMBL | |||||
| Sodium-dependent dopamine transporter | Transporter | Kd | 5.98 | SCIENTIFIC LITERATURE | |||||
| Histamine H1 receptor | GPCR | IC50 | 8.06 | CHEMBL | |||||
| Histamine H1 receptor | GPCR | Ki | 8.70 | CHEMBL | |||||
| Chloroquine resistance transporter | Transporter | IC50 | 4.27 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4017865 | VUID |
| N0000146218 | NUI |
| D00665 | KEGG_DRUG |
| 113-92-8 | SECONDARY_CAS_RN |
| 1405-56-7 | SECONDARY_CAS_RN |
| 142429 | RXNORM |
| C0008281 | UMLSCUI |
| CHEBI:52010 | CHEBI |
| CHEMBL505 | ChEMBL_ID |
| CHEMBL1659 | ChEMBL_ID |
| DB01114 | DRUGBANK_ID |
| 2725 | PUBCHEM_CID |
| 32347 | MMSL |
| 32562 | MMSL |
| 3966 | MMSL |
| 4425 | MMSL |
| 4426 | MMSL |
| 4427 | MMSL |
| 4751 | MMSL |
| 93262 | MMSL |
| d00191 | MMSL |
| 003391 | NDDF |
| 003392 | NDDF |
| 004430 | NDDF |
| 004431 | NDDF |
| 372914003 | SNOMEDCT_US |
| 438256006 | SNOMEDCT_US |
| 85737002 | SNOMEDCT_US |
| 9944001 | SNOMEDCT_US |
| D002744 | MESH_DESCRIPTOR_UI |
| CHEMBL1201659 | ChEMBL_ID |
| 6976 | IUPHAR_LIGAND_ID |
| 104 | INN_ID |
| 4017864 | VANDF |
| 4017865 | VANDF |
| 4018446 | VANDF |
| 4019408 | VANDF |
| 3U6IO1965U | UNII |
| 3U6IO1965U | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Childrens Robitussin Nighttime Cough Long-Acting DM | HUMAN OTC DRUG LABEL | 2 | 0031-8692 | SOLUTION | 2 mg | ORAL | OTC Monograph Drug | 17 sections |
| CHILDRENS ROBITUSSIN COUGH AND COLD LONG-ACTING | HUMAN OTC DRUG LABEL | 2 | 0031-8693 | LIQUID | 2 mg | ORAL | OTC Monograph Drug | 17 sections |
| Theraflu-D Flu Relief Max Strength plus Nasal Decongestant Nighttime | HUMAN OTC DRUG LABEL | 4 | 0067-0114 | SYRUP | 4 mg | ORAL | OTC Monograph Drug | 17 sections |
| Theraflu Flu Relief Max Strength Nighttime | HUMAN OTC DRUG LABEL | 3 | 0067-7922 | POWDER | 4 mg | ORAL | OTC Monograph Drug | 16 sections |
| Theraflu Flu Relief Max Strength Nighttime | HUMAN OTC DRUG LABEL | 3 | 0067-8205 | SYRUP | 4 mg | ORAL | OTC Monograph Drug | 17 sections |
| FLONASE Headache and Allergy Relief | HUMAN OTC DRUG LABEL | 3 | 0135-0578 | TABLET | 2 mg | ORAL | OTC Monograph Drug | 17 sections |
| Panadol Cold and Flu Night | HUMAN OTC DRUG LABEL | 3 | 0135-7034 | TABLET | 2 mg | ORAL | OTC Monograph Drug | 16 sections |
| Alka-Seltzer Plus Severe Cold PowerFast FizzOrange Zest | HUMAN OTC DRUG LABEL | 3 | 0280-0020 | TABLET, EFFERVESCENT | 2 mg | ORAL | OTC Monograph Drug | 17 sections |
| Alka-Seltzer Plus Severe Cold and Cough PowerFast Fizz | HUMAN OTC DRUG LABEL | 4 | 0280-0023 | TABLET, EFFERVESCENT | 2 mg | ORAL | OTC Monograph Drug | 16 sections |
| ANTIFLU | HUMAN OTC DRUG LABEL | 3 | 0280-0044 | TABLET, COATED | 2 mg | ORAL | Export only | 2 sections |
| Antiflupowder | HUMAN OTC DRUG LABEL | 3 | 0280-0045 | POWDER, FOR SOLUTION | 4 mg | ORAL | Export only | 1 sections |
| Antiflu Kids | HUMAN OTC DRUG LABEL | 3 | 0280-0046 | POWDER, FOR SOLUTION | 1 mg | ORAL | Export only | 2 sections |
| Alka-Seltzer Plus Maximum Strength Sinus Congestion and Pain PowerFast Fizz | HUMAN OTC DRUG LABEL | 4 | 0280-0055 | TABLET, EFFERVESCENT | 2 mg | ORAL | OTC Monograph Drug | 15 sections |
| Alka-Seltzer Plus Cold Sparkling Original PowerFast Fizz | HUMAN OTC DRUG LABEL | 3 | 0280-0060 | TABLET, EFFERVESCENT | 2 mg | ORAL | OTC Monograph Drug | 15 sections |
| Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz | HUMAN OTC DRUG LABEL | 4 | 0280-0088 | TABLET, EFFERVESCENT | 2 mg | ORAL | OTC Monograph Drug | 15 sections |
| Alka-Seltzer Plus Maximum Strength Cold and Cough Power Max Gels | HUMAN OTC DRUG LABEL | 4 | 0280-0092 | CAPSULE, LIQUID FILLED | 2 mg | ORAL | OTC Monograph Drug | 16 sections |
| Alka-Seltzer Plus Severe Cold Night PowerFast Fizz | HUMAN OTC DRUG LABEL | 4 | 0280-0121 | TABLET, EFFERVESCENT | 2 mg | ORAL | OTC Monograph Drug | 16 sections |
| Alka-Seltzer Plus Cold and Flu FizzyChews | HUMAN OTC DRUG LABEL | 3 | 0280-0151 | TABLET, CHEWABLE | 2 mg | ORAL | OTC Monograph Drug | 16 sections |
| Alka-Seltzer Plus Cold Medicine Sparkling Original | HUMAN OTC DRUG LABEL | 3 | 0280-1400 | TABLET, EFFERVESCENT | 2 mg | ORAL | OTC Monograph Drug | 17 sections |
| Alka-Seltzer Plus Cold Orange Zest | HUMAN OTC DRUG LABEL | 3 | 0280-1510 | TABLET, EFFERVESCENT | 2 mg | ORAL | OTC Monograph Drug | 17 sections |
| Alka-Seltzer Plus Cold Sparkling Original | HUMAN OTC DRUG LABEL | 3 | 0280-1520 | TABLET, EFFERVESCENT | 2 mg | ORAL | OTC Monograph Drug | 17 sections |
| Alka-Seltzer Plus Cold and Cough | HUMAN OTC DRUG LABEL | 4 | 0280-1555 | TABLET, EFFERVESCENT | 2 mg | ORAL | OTC Monograph Drug | 16 sections |
| Alka-Seltzer Plus Severe Cold and Flu | HUMAN OTC DRUG LABEL | 4 | 0280-1560 | TABLET, EFFERVESCENT | 2 mg | ORAL | OTC monograph final | 17 sections |
| Alka-Seltzer Plus Maximum Strength Cold and Cough Liquid Gels | HUMAN OTC DRUG LABEL | 4 | 0280-1570 | CAPSULE, LIQUID FILLED | 2 mg | ORAL | OTC Monograph Drug | 16 sections |
| Alka Seltzer Cold Cold and Congestion Severe Night Fast Dissolve | HUMAN OTC DRUG LABEL | 4 | 0280-8265 | TABLET, EFFERVESCENT | 2 mg | ORAL | OTC Monograph Drug | 16 sections |
| ALKA SELTZER COLD Cold and Headache Maximum Strength Fast DissolveOrange | HUMAN OTC DRUG LABEL | 3 | 0280-8266 | TABLET, EFFERVESCENT | 2 mg | ORAL | OTC Monograph Drug | 17 sections |
| ALKA SELTZER COLD Cold and Cough Maximum Strength Fast Dissolve | HUMAN OTC DRUG LABEL | 4 | 0280-8267 | TABLET, EFFERVESCENT | 2 mg | ORAL | OTC Monograph Drug | 16 sections |
| ALKA SELTZER COLD Cold Flu and Congestion Severe Fast Dissolve | HUMAN OTC DRUG LABEL | 4 | 0280-8268 | TABLET, EFFERVESCENT | 2 mg | ORAL | OTC Monograph Drug | 15 sections |
| ALKA SELTZER COLD Cold and Flu Severe Fast Chewables | HUMAN OTC DRUG LABEL | 3 | 0280-8269 | TABLET, CHEWABLE | 2 mg | ORAL | OTC Monograph Drug | 15 sections |
| ALKA SELTZER COLD Cold and Headache Maximum Strength Fast Dissolve | HUMAN OTC DRUG LABEL | 3 | 0280-8270 | TABLET, EFFERVESCENT | 2 mg | ORAL | OTC Monograph Drug | 14 sections |