chlorphenamine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
616 132-22-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • chlorphenamine
  • chloropheniramine
  • chlorophenylpyridamine
  • chloroprophenpyridamine
  • chlorpheniramine
  • chlorprophenpyridamine
  • chlorpheniramine maleate
  • chlorpheniramine tannate
  • chlorpheniramine polistirex
A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.
  • Molecular weight: 274.79
  • Formula: C16H19ClN2
  • CLOGP: 3.15
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 16.13
  • ALOGS: -3.72
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
12 mg O
12 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.48 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 41 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.70 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 22 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 15, 1950 FDA BAYER HEALTHCARE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 113.75 13.78 80 19348 817165 52512473
Neutropenic sepsis 110.52 13.78 68 19360 14581 53315057
Dilatation intrahepatic duct acquired 101.49 13.78 28 19400 734 53328904
Neutropenia 92.78 13.78 189 19239 158996 53170642
Febrile neutropenia 86.87 13.78 145 19283 104791 53224847
Rheumatoid arthritis 85.54 13.78 8 19420 314523 53015115
Dyspnoea 75.40 13.78 415 19013 585817 52743821
Neuropathy peripheral 71.65 13.78 132 19296 103055 53226583
Anaphylactic reaction 67.19 13.78 94 19334 58232 53271406
Pyrexia 62.52 13.78 301 19127 402892 52926746
Flushing 60.32 13.78 99 19329 70501 53259137
Mucosal inflammation 60.11 13.78 76 19352 42708 53286930
Eosinophilic colitis 58.46 13.78 13 19415 134 53329504
Erythema 53.07 13.78 151 19277 156818 53172820
Ejection fraction decreased 50.15 13.78 48 19380 19800 53309838
Excessive eye blinking 46.56 13.78 16 19412 883 53328755
Diarrhoea 45.48 13.78 385 19043 625161 52704477
Drug intolerance 44.82 13.78 10 19418 205483 53124155
Vomiting 43.81 13.78 320 19108 496819 52832819
Chest discomfort 42.94 13.78 105 19323 99590 53230048
Pain 39.96 13.78 98 19330 588300 52741338
Tachycardia 38.41 13.78 106 19322 108106 53221532
Infusion related reaction 33.76 13.78 129 19299 155828 53173810
Rash 33.05 13.78 276 19152 445915 52883723
Arthropathy 32.67 13.78 6 19422 141447 53188191
Venoocclusive liver disease 31.39 13.78 20 19408 4552 53325086
Biliary sepsis 30.74 13.78 12 19416 952 53328686
Systemic lupus erythematosus 29.65 13.78 5 19423 125409 53204229
Diffuse large B-cell lymphoma refractory 29.46 13.78 12 19416 1064 53328574
Tonsillar hypertrophy 28.34 13.78 11 19417 859 53328779
Victim of chemical submission 27.32 13.78 8 19420 261 53329377
Electrocardiogram QRS complex prolonged 27.26 13.78 20 19408 5722 53323916
Swelling face 26.52 13.78 62 19366 57106 53272532
Cough 26.46 13.78 172 19256 256721 53072917
Constipation 26.32 13.78 142 19286 198270 53131368
Gallbladder polyp 25.99 13.78 10 19418 763 53328875
Exposure to toxic agent 25.96 13.78 13 19415 1867 53327771
Lip swelling 25.76 13.78 40 19388 27161 53302477
Therapeutic product effect decreased 23.85 13.78 8 19420 125647 53203991
Lower respiratory tract infection 23.71 13.78 80 19348 90901 53238737
Abdominal pain 23.17 13.78 166 19262 255737 53073901
Rash maculo-papular 23.11 13.78 40 19388 29709 53299929
Acute interstitial pneumonitis 22.94 13.78 9 19419 723 53328915
Vulvovaginal candidiasis 22.92 13.78 14 19414 2959 53326679
Oropharyngeal pain 22.55 13.78 73 19355 81195 53248443
Genital ulceration 22.52 13.78 8 19420 487 53329151
Accidental overdose 22.34 13.78 33 19395 21446 53308192
Drug abuse 22.06 13.78 63 19365 65463 53264175
Dyspnoea at rest 21.76 13.78 15 19413 3892 53325746
Electrocardiogram QT prolonged 21.75 13.78 57 19371 56346 53273292
Throat tightness 21.50 13.78 33 19395 22183 53307455
Musculoskeletal stiffness 21.49 13.78 9 19419 123359 53206279
Treatment failure 21.37 13.78 10 19418 128393 53201245
Hyperpyrexia 21.22 13.78 14 19414 3380 53326258
Laryngospasm 20.49 13.78 13 19415 2937 53326701
Terminal ileitis 20.47 13.78 8 19420 636 53329002
Chemical burns of eye 20.23 13.78 5 19423 84 53329554
Hypokalaemia 20.18 13.78 79 19349 96438 53233200
Eosinophilic myocarditis 20.12 13.78 7 19421 401 53329237
Nystagmus 19.98 13.78 17 19411 6019 53323619
Chest pain 19.96 13.78 128 19300 190057 53139581
Nausea 19.72 13.78 385 19043 755706 52573932
Arthralgia 19.60 13.78 88 19340 439695 52889943
Swollen tongue 19.36 13.78 38 19390 31042 53298596
Neutrophil count decreased 19.32 13.78 50 19378 49048 53280590
Joint swelling 19.27 13.78 35 19393 234603 53095035
Hepatic enzyme increased 19.26 13.78 11 19417 126184 53203454
Feeling hot 19.20 13.78 45 19383 41499 53288139
Nail infection 18.93 13.78 11 19417 2123 53327515
Prosopagnosia 18.68 13.78 4 19424 34 53329604
Back pain 18.40 13.78 147 19281 234100 53095538
Onychalgia 18.23 13.78 8 19420 853 53328785
Cytomegalovirus test positive 18.09 13.78 12 19416 2923 53326715
Pancreatitis chronic 17.61 13.78 11 19417 2419 53327219
Presyncope 17.51 13.78 33 19395 26161 53303477
Agitation 17.49 13.78 54 19374 58572 53271066
Petechiae 17.27 13.78 23 19405 13582 53316056
Hepatotoxicity 17.26 13.78 34 19394 27846 53301792
Wound 17.07 13.78 6 19422 91551 53238087
Retinal detachment 17.03 13.78 15 19413 5560 53324078
HER2 positive breast cancer 16.88 13.78 6 19422 366 53329272
Venoocclusive disease 16.68 13.78 10 19418 2045 53327593
Macroglossia 16.60 13.78 7 19421 677 53328961
Administration site extravasation 16.18 13.78 7 19421 721 53328917
Depressed level of consciousness 16.11 13.78 50 19378 54378 53275260
Maternal exposure during pregnancy 15.88 13.78 20 19408 155619 53174019
Pruritus 15.81 13.78 170 19258 293662 53035976
Tympanic membrane hyperaemia 15.22 13.78 3 19425 16 53329622
Bronchospasm 15.15 13.78 24 19404 16574 53313064
Wheezing 14.93 13.78 55 19373 65220 53264418
Overdose 14.87 13.78 78 19350 107658 53221980
Rash macular 14.86 13.78 27 19401 20820 53308818
Haemodialysis complication 14.82 13.78 5 19423 261 53329377
Abdominal discomfort 14.79 13.78 37 19391 221025 53108613
Weight increased 14.67 13.78 33 19395 204534 53125104
Dysaesthesia 14.62 13.78 12 19416 4043 53325595
Fall 14.62 13.78 74 19354 358366 52971272
Suffocation feeling 14.61 13.78 8 19420 1379 53328259
Renal failure 14.57 13.78 13 19415 118439 53211199
Hypersensitivity 14.31 13.78 128 19300 210537 53119101
Stevens-Johnson syndrome 14.05 13.78 29 19399 24553 53305085
Candida test positive 14.03 13.78 7 19421 997 53328641
Culture stool positive 13.96 13.78 5 19423 312 53329326

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Lower respiratory tract infection 109.62 14.99 91 12594 29152 32471689
Febrile neutropenia 95.79 14.99 169 12516 119397 32381444
Drug abuse 95.50 14.99 136 12549 80107 32420734
Infusion related reaction 85.56 14.99 97 12588 45502 32455339
Neutropenic sepsis 75.29 14.99 52 12633 12647 32488194
Toxicity to various agents 68.20 14.99 187 12498 177854 32322987
Painful respiration 57.37 14.99 21 12664 1301 32499540
Urticaria 55.22 14.99 90 12595 59524 32441317
Walking aid user 54.09 14.99 21 12664 1531 32499310
Chest injury 53.94 14.99 21 12664 1543 32499298
Toxic epidermal necrolysis 51.36 14.99 51 12634 20542 32480299
Pruritus 49.01 14.99 135 12550 128567 32372274
Lip swelling 47.76 14.99 41 12644 13724 32487117
Flushing 44.92 14.99 58 12627 31069 32469772
Rash 43.51 14.99 179 12506 209154 32291687
Tachycardia 40.61 14.99 93 12592 78995 32421846
Pyrexia 40.27 14.99 237 12448 319731 32181110
Hypersomnia 36.25 14.99 33 12652 11928 32488913
Dry skin 33.64 14.99 45 12640 24933 32475908
Oral candidiasis 32.25 14.99 31 12654 11996 32488845
Aortic aneurysm 31.78 14.99 24 12661 6695 32494146
Failure to anastomose 31.51 14.99 9 12676 250 32500591
Oropharyngeal blistering 29.12 14.99 8 12677 192 32500649
Feeling cold 29.01 14.99 27 12658 10037 32490804
Neutropenia 25.94 14.99 117 12568 142058 32358783
Respiratory arrest 24.54 14.99 42 12643 28866 32471975
Limb mass 23.61 14.99 9 12676 624 32500217
General physical health deterioration 23.21 14.99 8 12677 115251 32385590
Chills 23.11 14.99 75 12610 78009 32422832
Transient aphasia 23.07 14.99 6 12679 116 32500725
Pneumonitis 22.01 14.99 41 12644 30093 32470748
Hypersensitivity 21.35 14.99 60 12625 57698 32443143
Anaplastic astrocytoma 21.20 14.99 6 12679 161 32500680
Malaise 20.76 14.99 129 12556 177009 32323832
Ingrowing nail 20.28 14.99 9 12676 919 32499922
HIV associated nephropathy 20.19 14.99 7 12678 370 32500471
Hypoxic-ischaemic encephalopathy 20.05 14.99 16 12669 4838 32496003
Erythema 19.56 14.99 74 12611 83031 32417810
Anaphylactic reaction 19.52 14.99 39 12646 30133 32470708
Hot flush 19.27 14.99 27 12658 15619 32485222
Exposure to toxic agent 18.91 14.99 9 12676 1079 32499762
Drug ineffective 18.49 14.99 82 12603 383395 32117446
Accidental exposure to product by child 18.30 14.99 10 12675 1601 32499240
Swelling face 18.19 14.99 32 12653 22473 32478368
Lip dry 17.91 14.99 9 12676 1215 32499626
Serotonin syndrome 17.86 14.99 29 12656 19088 32481753
Rash macular 17.83 14.99 22 12663 11248 32489593
Hypoacusis 17.80 14.99 26 12659 15615 32485226
Eyelid oedema 16.83 14.99 15 12670 5274 32495567
Bradycardia foetal 16.67 14.99 6 12679 354 32500487
Accidental overdose 16.28 14.99 28 12657 19311 32481530
Oxygen saturation decreased 15.88 14.99 48 12637 48051 32452790
Dermatitis exfoliative 15.58 14.99 17 12668 7627 32493214
Rash erythematous 15.55 14.99 31 12654 23908 32476933
Gait disturbance 15.47 14.99 6 12679 80402 32420439
Drug hypersensitivity 15.36 14.99 63 12622 73337 32427504
Second primary malignancy 15.14 14.99 16 12669 6925 32493916

Pharmacologic Action:

SourceCodeDescription
ATC R06AB04 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Substituted alkylamines
ATC R06AB54 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Substituted alkylamines
FDA MoA N0000000190 Histamine H1 Receptor Antagonists
FDA EPC N0000175587 Histamine-1 Receptor Antagonist
MeSH PA D018926 Anti-Allergic Agents
MeSH PA D000982 Antipruritics
MeSH PA D003879 Dermatologic Agents
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D018377 Neurotransmitter Agents
CHEBI has role CHEBI:35469 thymoanaleptics
CHEBI has role CHEBI:37955 H1-receptor blockers
CHEBI has role CHEBI:37956 histamine receptor blocker
CHEBI has role CHEBI:50857 anti-allergic agents
CHEBI has role CHEBI:50949 serotonin reuptake inhibitor
CHEBI has role CHEBI:59683 anti-itching drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Dermatographic urticaria indication 7632005 DOID:743
Vasomotor rhinitis indication 8229003 DOID:4730
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Sneezing indication 76067001
Common cold indication 82272006 DOID:10459
Urticaria indication 126485001
Influenza-like symptoms indication 315642008
Seasonal allergic rhinitis indication 367498001
Itching of skin indication 418363000
Allergic conjunctivitis indication 473460002 DOID:11204
Brain damage contraindication 2470005
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Goiter contraindication 3716002 DOID:12176
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Asthenia contraindication 13791008
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Constipation contraindication 14760008 DOID:2089
Disorder of autonomic nervous system contraindication 15241006
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Hashimoto thyroiditis contraindication 21983002
Myocardial infarction contraindication 22298006 DOID:5844
Glaucoma contraindication 23986001 DOID:1686
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Ventricular tachycardia contraindication 25569003
Acute tuberculosis contraindication 25629007
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Hypercapnia contraindication 29596007
Bronchitis contraindication 32398004 DOID:6132
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Hypovolemic shock contraindication 39419009
Disorder of gallbladder contraindication 39621005 DOID:0060262
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Acidosis contraindication 51387008
Gastrointestinal perforation contraindication 51875005
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Paralytic ileus contraindication 55525008 DOID:8442
Peptic reflux disease contraindication 57643001
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Psychotic disorder contraindication 69322001
Poisoning by acetaminophen contraindication 70273001
Agoraphobia contraindication 70691001 DOID:593
Arteriosclerotic vascular disease contraindication 72092001
Diabetes mellitus contraindication 73211009 DOID:9351
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Gastrointestinal hemorrhage contraindication 74474003
Urethral stricture contraindication 76618002
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Cor pulmonale contraindication 83291003 DOID:8515
Hiatal hernia contraindication 84089009 DOID:12642
Epilepsy contraindication 84757009 DOID:1826
Pulmonary emphysema contraindication 87433001
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Myasthenia gravis contraindication 91637004 DOID:437
Dermatitis herpetiformis contraindication 111196000 DOID:8505
Anemia due to enzyme deficiency contraindication 111577008
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
von Willebrand disorder contraindication 128105004 DOID:12531
Seizure disorder contraindication 128613002
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Drug-induced psychosis contraindication 191483003 DOID:1742
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Coronary artery bypass graft contraindication 232717009
Myocardial dysfunction contraindication 233928007
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Morbid obesity contraindication 238136002 DOID:11981
Hypocomplementemic urticarial vasculitis contraindication 239945009
Pyloric obstruction contraindication 244815007
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Drowsy contraindication 271782001
Exacerbation of asthma contraindication 281239006
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Panic disorder contraindication 371631005 DOID:594
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Cardiovascular event risk contraindication 395112001
Pseudomembranous enterocolitis contraindication 397683000
Gastric ulcer contraindication 397825006 DOID:10808
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Central nervous system depression contraindication 418072004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Fever greater than 100.4 Fahrenheit contraindication 426000000
Dysfunction of sphincter of Oddi contraindication 430887001
Hypertensive urgency contraindication 443482000
Acute erosive gastritis contraindication 444926003
Smokes tobacco daily contraindication 449868002
Acute exacerbation of asthma contraindication 708038006
Acute Thromboembolic Stroke contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.47 Basic
pKa2 4.14 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
8MG;54.3MG TUXARIN ER MAINPOINTE N206323 June 22, 2015 RX TABLET, EXTENDED RELEASE ORAL 9066942 Jan. 3, 2032 TREATMENT OF COUGH AND SYMPTOMS ASSOCIATED WITH UPPER RESPIRATORY ALLERGIES OR A COMMON COLD WITH CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE ORALLY ADMINISTERED EXTENDED RELEASE TABLETS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST Ki 8.15 WOMBAT-PK CHEMBL
Sodium-dependent serotonin transporter Transporter Kd 7.82 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 5.17 PDSP
Histamine H4 receptor GPCR Ki 6.67 WOMBAT-PK
Cytochrome P450 2D6 Enzyme Ki 4.97 WOMBAT-PK
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 5 CHEMBL
Lethal(3)malignant brain tumor-like protein 1 Unclassified IC50 4.39 CHEMBL
Lethal(3)malignant brain tumor-like protein 3 Unclassified IC50 4.38 CHEMBL
MBT domain-containing protein 1 Unclassified IC50 4.47 CHEMBL
Sodium-dependent noradrenaline transporter Transporter Kd 5.84 SCIENTIFIC LITERATURE
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.96 CHEMBL
Sodium-dependent dopamine transporter Transporter Kd 5.98 SCIENTIFIC LITERATURE
Histamine H1 receptor GPCR IC50 8.06 CHEMBL
Histamine H1 receptor GPCR Ki 8.70 CHEMBL
Chloroquine resistance transporter Transporter IC50 4.27 CHEMBL

External reference:

IDSource
4017865 VUID
N0000146218 NUI
D00665 KEGG_DRUG
113-92-8 SECONDARY_CAS_RN
C0008281 UMLSCUI
CHEBI:52010 CHEBI
CHEMBL505 ChEMBL_ID
CHEMBL1659 ChEMBL_ID
DB01114 DRUGBANK_ID
6976 IUPHAR_LIGAND_ID
104 INN_ID
3U6IO1965U UNII
2725 PUBCHEM_CID
142429 RXNORM
32347 MMSL
32562 MMSL
3966 MMSL
4425 MMSL
4426 MMSL
4427 MMSL
4751 MMSL
93262 MMSL
d00191 MMSL
003391 NDDF
003392 NDDF
004430 NDDF
004431 NDDF
372914003 SNOMEDCT_US
438256006 SNOMEDCT_US
85737002 SNOMEDCT_US
9944001 SNOMEDCT_US
D002744 MESH_DESCRIPTOR_UI
4017864 VANDF
4017865 VANDF
4018446 VANDF
4019408 VANDF
CHEMBL1201659 ChEMBL_ID

Pharmaceutical products:

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Childrens Robitussin Nighttime Cough Long-Acting DM HUMAN OTC DRUG LABEL 2 0031-8692 SOLUTION 2 mg ORAL OTC monograph final 17 sections
CHILDRENS ROBITUSSIN COUGH AND COLD LONG-ACTING HUMAN OTC DRUG LABEL 2 0031-8693 LIQUID 1 mg ORAL OTC monograph final 17 sections
TriaminicMulti-Symptom Fever and Cold HUMAN OTC DRUG LABEL 4 0067-8116 SUSPENSION 1 mg ORAL OTC monograph final 15 sections
good sense cold HUMAN OTC DRUG LABEL 4 0113-0903 SUSPENSION 1 mg ORAL OTC monograph final 15 sections
Allergy HUMAN OTC DRUG LABEL 3 0113-2476 TABLET 2 mg ORAL OTC monograph final 15 sections
basic care childrens cold plus flu HUMAN OTC DRUG LABEL 4 0113-7223 SUSPENSION 1 mg ORAL OTC monograph final 15 sections
TussiCaps HUMAN PRESCRIPTION DRUG LABEL 2 0187-0054 CAPSULE, EXTENDED RELEASE 4 mg ORAL ANDA 24 sections
TussiCaps HUMAN PRESCRIPTION DRUG LABEL 2 0187-0108 CAPSULE, EXTENDED RELEASE 8 mg ORAL ANDA 24 sections
Alka-Seltzer Plus Severe Cold PowerFast FizzOrange Zest HUMAN OTC DRUG LABEL 3 0280-0020 TABLET, EFFERVESCENT 2 mg ORAL OTC monograph final 17 sections
Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz HUMAN OTC DRUG LABEL 4 0280-0022 TABLET, EFFERVESCENT 2 mg ORAL OTC monograph final 16 sections
Alka-Seltzer Plus Severe Cold and Cough PowerFast Fizz HUMAN OTC DRUG LABEL 4 0280-0023 TABLET, EFFERVESCENT 2 mg ORAL OTC monograph final 15 sections
ANTIFLU HUMAN OTC DRUG LABEL 3 0280-0044 TABLET, COATED 2 mg ORAL Export only 2 sections
Antiflupowder HUMAN OTC DRUG LABEL 3 0280-0045 POWDER, FOR SOLUTION 4 mg ORAL Export only 1 sections
Antiflu Kids HUMAN OTC DRUG LABEL 3 0280-0046 POWDER, FOR SOLUTION 1 mg ORAL Export only 2 sections
Alka-Seltzer Plus Maximum Strength Sinus Congestion and Pain PowerFast Fizz HUMAN OTC DRUG LABEL 4 0280-0055 TABLET, EFFERVESCENT 2 mg ORAL OTC monograph final 15 sections
Alka-Seltzer Plus Cold Sparkling Original PowerFast Fizz HUMAN OTC DRUG LABEL 3 0280-0060 TABLET, EFFERVESCENT 2 mg ORAL OTC monograph final 15 sections
Alka-Seltzer Plus Cold Medicine Sparkling Original HUMAN OTC DRUG LABEL 3 0280-1400 TABLET, EFFERVESCENT 2 mg ORAL OTC monograph not final 17 sections
Alka-Seltzer Plus Cold Orange Zest HUMAN OTC DRUG LABEL 3 0280-1510 TABLET, EFFERVESCENT 2 mg ORAL OTC monograph final 17 sections
Alka-Seltzer Plus Cold Sparkling Original HUMAN OTC DRUG LABEL 3 0280-1520 TABLET, EFFERVESCENT 2 mg ORAL OTC monograph final 17 sections
Alka-Seltzer Plus Cold and Cough HUMAN OTC DRUG LABEL 4 0280-1555 TABLET, EFFERVESCENT 2 mg ORAL OTC monograph final 16 sections
Alka-Seltzer Plus Severe Cold and Flu HUMAN OTC DRUG LABEL 4 0280-1560 TABLET, EFFERVESCENT 2 mg ORAL OTC monograph final 17 sections
Alka-Seltzer Plus Maximum Strength Cold and Cough HUMAN OTC DRUG LABEL 4 0280-1570 CAPSULE, LIQUID FILLED 2 mg ORAL OTC monograph final 17 sections
Childrens Plus Multi Symptom Cold HUMAN OTC DRUG LABEL 4 0363-0034 SUSPENSION 1 mg ORAL OTC MONOGRAPH FINAL 15 sections
Wal-phed HUMAN OTC DRUG LABEL 2 0363-0111 TABLET 4 mg ORAL OTC monograph final 16 sections
Childrens Plus Cough and Runny Nose HUMAN OTC DRUG LABEL 3 0363-0297 SUSPENSION 1 mg ORAL OTC MONOGRAPH FINAL 15 sections
Wal-Finate D HUMAN OTC DRUG LABEL 2 0363-0382 TABLET 4 mg ORAL OTC MONOGRAPH FINAL 16 sections
Flu HBP HUMAN OTC DRUG LABEL 3 0363-0461 TABLET, FILM COATED 2 mg ORAL OTC monograph final 16 sections
Wal-Phed PEMaximum Strength HUMAN OTC DRUG LABEL 2 0363-0462 TABLET 4 mg ORAL OTC monograph final 16 sections
Wal-Finate HUMAN OTC DRUG LABEL 1 0363-0491 TABLET 4 mg ORAL OTC monograph final 15 sections
Multi-Symptom Allergy HUMAN OTC DRUG LABEL 3 0363-0559 TABLET 2 mg ORAL OTC monograph final 16 sections