chlorothiazide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| diuretics, chlorothiazide derivatives | 609 | 58-94-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.50 | g | O |
| 0.50 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 4 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.70 mg/mL | Bocci G, Oprea TI, Benet LZ |
| EoM (Fraction excreted unchanged in urine) | 92 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 112.60 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 13 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 4, 1958 | FDA | OAK PHARMS AKORN |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Pulmonary vein stenosis | 35.55 | 27.11 | 5 | 1081 | 83 | 63487853 |
| Rhinovirus infection | 33.91 | 27.11 | 9 | 1077 | 4520 | 63483416 |
| Respiratory failure | 30.71 | 27.11 | 20 | 1066 | 101838 | 63386098 |
| Hypervolaemia | 30.28 | 27.11 | 13 | 1073 | 28400 | 63459536 |
| Hypoxia | 29.13 | 27.11 | 16 | 1070 | 59776 | 63428160 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Respiratory failure | 42.23 | 26.29 | 34 | 1292 | 108538 | 34847067 |
| Hyperparathyroidism secondary | 41.34 | 26.29 | 10 | 1316 | 1558 | 34954047 |
| Pulmonary hypertension | 35.99 | 26.29 | 17 | 1309 | 20907 | 34934698 |
| Respiratory distress | 32.67 | 26.29 | 19 | 1307 | 35646 | 34919959 |
| Serotonin syndrome | 27.68 | 26.29 | 14 | 1312 | 19919 | 34935686 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Respiratory distress | 50.86 | 24.23 | 27 | 2176 | 58312 | 79683873 |
| Respiratory failure | 50.58 | 24.23 | 41 | 2162 | 180870 | 79561315 |
| Hospitalisation | 41.26 | 24.23 | 28 | 2175 | 94208 | 79647977 |
| Hyperparathyroidism secondary | 39.23 | 24.23 | 10 | 2193 | 2650 | 79739535 |
| Pulmonary vein stenosis | 37.11 | 24.23 | 6 | 2197 | 159 | 79742026 |
| Hypoxia | 36.68 | 24.23 | 27 | 2176 | 103216 | 79638969 |
| Pulmonary hypertension | 35.65 | 24.23 | 20 | 2183 | 48060 | 79694125 |
| Pulmonary arterial hypertension | 33.10 | 24.23 | 16 | 2187 | 28350 | 79713835 |
| Rhinovirus infection | 32.29 | 24.23 | 11 | 2192 | 7942 | 79734243 |
| Hypervolaemia | 29.60 | 24.23 | 17 | 2186 | 42673 | 79699512 |
| Catheterisation cardiac | 27.54 | 24.23 | 9 | 2194 | 5719 | 79736466 |
| Tracheitis | 24.63 | 24.23 | 6 | 2197 | 1322 | 79740863 |
| Cardiac operation | 24.61 | 24.23 | 8 | 2195 | 5004 | 79737181 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C03AA04 | CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, THIAZIDES Thiazides, plain |
| ATC | C03AB04 | CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, THIAZIDES Thiazides and potassium in combination |
| ATC | C03AH01 | CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, THIAZIDES Thiazides, combinations with psycholeptics and/or analgesics |
| FDA CS | M0471776 | Thiazides |
| FDA PE | N0000175359 | Increased Diuresis |
| FDA EPC | N0000175419 | Thiazide Diuretic |
| CHEBI has role | CHEBI:35498 | diuretics |
| CHEBI has role | CHEBI:35674 | antihypertensive drugs |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D004232 | Diuretics |
| MeSH PA | D049990 | Membrane Transport Modulators |
| MeSH PA | D045283 | Natriuretic Agents |
| MeSH PA | D049993 | Sodium Chloride Symporter Inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
| Chronic heart failure | indication | 48447003 | |
| Edema | indication | 267038008 | |
| Hypertensive urgency | indication | 443482000 | |
| Edema due to Nephrotic Syndrome | indication | ||
| Edema due to Hepatic Cirrhosis | indication | ||
| Hypertension with Left Ventricular Hypertrophy | indication | ||
| Pulmonary Edema due to Chronic Heart Failure | indication | ||
| Peripheral Edema due to Chronic Heart Failure | indication | ||
| Nephrogenic diabetes insipidus | off-label use | 111395007 | DOID:12387 |
| Calcium renal calculus | off-label use | 427649000 | |
| Anuria | contraindication | 2472002 | DOID:2983 |
| Bronchospasm | contraindication | 4386001 | |
| Suicidal thoughts | contraindication | 6471006 | |
| Psoriasis | contraindication | 9014002 | DOID:8893 |
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Hypercholesterolemia | contraindication | 13644009 | |
| Hyperkalemia | contraindication | 14140009 | |
| Chronic disease of respiratory system | contraindication | 17097001 | |
| Metabolic acidosis, normal anion gap, acidifying salts | contraindication | 18104000 | |
| Jaundice | contraindication | 18165001 | |
| Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
| Secondary angle-closure glaucoma | contraindication | 21571006 | |
| Electroconvulsive therapy | contraindication | 23835007 | |
| Acute vomiting | contraindication | 23971007 | |
| Complete atrioventricular block | contraindication | 27885002 | |
| Hypovolemia | contraindication | 28560003 | |
| Acute cerebrovascular insufficiency | contraindication | 29322000 | |
| Obstruction of bile duct | contraindication | 30144000 | |
| Parkinsonism | contraindication | 32798002 | |
| Dehydration | contraindication | 34095006 | |
| Depressive disorder | contraindication | 35489007 | |
| Hyperuricemia | contraindication | 35885006 | DOID:1920 |
| Sick sinus syndrome | contraindication | 36083008 | DOID:13884 |
| Acute hepatitis | contraindication | 37871000 | |
| Immunosuppression | contraindication | 38013005 | |
| Anaphylaxis | contraindication | 39579001 | |
| Angioedema | contraindication | 41291007 | DOID:1558 |
| Hypokalemia | contraindication | 43339004 | |
| Diabetes mellitus type 2 | contraindication | 44054006 | DOID:9352 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Low blood pressure | contraindication | 45007003 | |
| Diabetes mellitus type 1 | contraindication | 46635009 | DOID:9744 |
| Sinus bradycardia | contraindication | 49710005 | |
| Cough | contraindication | 49727002 | |
| Acidosis | contraindication | 51387008 | |
| Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
| Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
| Sympathectomy | contraindication | 57071006 | |
| Acute nephropathy | contraindication | 58574008 | |
| Hepatic failure | contraindication | 59927004 | |
| Aortic valve stenosis | contraindication | 60573004 | DOID:1712 |
| Chronic bronchitis | contraindication | 63480004 | DOID:6132 |
| Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
| Hypercalcemia | contraindication | 66931009 | DOID:12678 |
| Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
| Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
| Hypochloremic alkalosis | contraindication | 70134007 | |
| Hepatic coma | contraindication | 72836002 | DOID:12550 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Wolff-Parkinson-White pattern | contraindication | 74390002 | DOID:384 |
| Transplantation | contraindication | 77465005 | |
| Chronic idiopathic constipation | contraindication | 82934008 | |
| Hereditary angioneurotic edema | contraindication | 82966003 | DOID:14735 |
| Oliguria | contraindication | 83128009 | |
| Epilepsy | contraindication | 84757009 | DOID:1826 |
| Megaloblastic anemia due to folate deficiency | contraindication | 85649008 | DOID:14026 |
| Pulmonary emphysema | contraindication | 87433001 | |
| Cardiogenic shock | contraindication | 89138009 | |
| Hyponatremia | contraindication | 89627008 | |
| Gout | contraindication | 90560007 | DOID:13189 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Myasthenia gravis | contraindication | 91637004 | DOID:437 |
| Kidney stone | contraindication | 95570007 | |
| Disorder of connective tissue | contraindication | 105969002 | DOID:65 |
| Diabetic renal disease | contraindication | 127013003 | |
| Disorder of muscle | contraindication | 129565002 | DOID:423 |
| Liver function tests abnormal | contraindication | 166603001 | |
| Hypomagnesemia | contraindication | 190855004 | |
| Angina pectoris | contraindication | 194828000 | |
| Partial atrioventricular block | contraindication | 195039008 | |
| Second degree atrioventricular block | contraindication | 195042002 | |
| Decompensated cardiac failure | contraindication | 195111005 | |
| Asthma | contraindication | 195967001 | DOID:2841 |
| Acute hepatic failure | contraindication | 197270009 | |
| Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
| Impaired renal function disorder | contraindication | 197663003 | |
| Cerebrovascular accident | contraindication | 230690007 | |
| Hypertrophic cardiomyopathy | contraindication | 233873004 | DOID:11984 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Hypoglycemic disorder | contraindication | 237630007 | |
| Disorder of electrolytes | contraindication | 237840007 | |
| Lupus erythematosus and erythema multiforme-like syndrome | contraindication | 238926009 | |
| Rhabdomyolysis | contraindication | 240131006 | |
| Raynaud's phenomenon | contraindication | 266261006 | |
| Calculus in biliary tract | contraindication | 266474003 | |
| Anemia | contraindication | 271737000 | DOID:2355 |
| Neonatal hyperbilirubinemia | contraindication | 281610001 | |
| Pregnancy, function | contraindication | 289908002 | |
| Renal artery stenosis | contraindication | 302233006 | |
| Pheochromocytoma | contraindication | 302835009 | |
| Hypertriglyceridemia | contraindication | 302870006 | |
| Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
| Bone marrow depression | contraindication | 307762000 | |
| Severe chronic obstructive pulmonary disease | contraindication | 313299006 | |
| Right ventricular failure | contraindication | 367363000 | |
| Surgical procedure | contraindication | 387713003 | |
| Peripheral arterial occlusive disease | contraindication | 399957001 | |
| Peripheral vascular disease | contraindication | 400047006 | |
| Severe diarrhea | contraindication | 409587002 | |
| Autoimmune hemolytic anemia | contraindication | 413603009 | DOID:718 |
| Disorder of coronary artery | contraindication | 414024009 | |
| Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
| Myocardial infarction in recovery phase | contraindication | 418044006 | |
| Porphyria | contraindication | 418470004 | |
| Intraoperative floppy iris syndrome | contraindication | 418801006 | |
| Poor metabolizer due to cytochrome p450 CYP2D6 variant | contraindication | 423629005 | |
| Slow acetylator due to N-acetyltransferase enzyme variant | contraindication | 425079005 | |
| Azotemia | contraindication | 445009001 | |
| Smokes tobacco daily | contraindication | 449868002 | |
| Acute exacerbation of asthma | contraindication | 708038006 | |
| Severe Cerebrovascular Disease | contraindication | ||
| Hemodialysis with High-Flux Membrane | contraindication | ||
| Head and Neck Angioedema | contraindication | ||
| First Degree Atrioventricular Heart Block | contraindication | ||
| Intestinal Angioedema | contraindication | ||
| Severe Aortic Valve Stenosis | contraindication |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Dogs | Congestive heart failure | Indication |
| Dogs | Renal edema | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Diuril Tablet | Boehringer lngelheim Animal Health USA Inc. | 1 |
| Diuril | Boehringer lngelheim Animal Health USA Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.53 | acidic |
| pKa2 | 9.74 | acidic |
| pKa3 | 4.58 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Solute carrier family 12 member 3 | Transporter | INHIBITOR | A2 | 5.43 | WOMBAT-PK | CHEMBL | |||
| Carbonic anhydrase 2 | Enzyme | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| 4017731 | VUID |
| N0000146099 | NUI |
| D00519 | KEGG_DRUG |
| 7085-44-1 | SECONDARY_CAS_RN |
| 2396 | RXNORM |
| 4017731 | VANDF |
| 4017732 | VANDF |
| C0008273 | UMLSCUI |
| CHEBI:3640 | CHEBI |
| CHEMBL842 | ChEMBL_ID |
| DB00880 | DRUGBANK_ID |
| CHEMBL1200616 | ChEMBL_ID |
| D002740 | MESH_DESCRIPTOR_UI |
| 2720 | PUBCHEM_CID |
| 4835 | IUPHAR_LIGAND_ID |
| 636 | INN_ID |
| 77W477J15H | UNII |
| 169210 | MMSL |
| 3950 | MMSL |
| 4419 | MMSL |
| 4420 | MMSL |
| d00190 | MMSL |
| 002292 | NDDF |
| 002293 | NDDF |
| 372782002 | SNOMEDCT_US |
| 5786005 | SNOMEDCT_US |
| 8252004 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Chlorothiazide Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0517-1820 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 24 sections |
| Chlorothiazide Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-419 | INJECTION | 500 mg | INTRAVENOUS | NDA authorized generic | 25 sections |
| Chlorothiazide Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-419 | INJECTION | 500 mg | INTRAVENOUS | NDA authorized generic | 25 sections |
| chlorothiazide sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-305 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 25 sections |
| chlorothiazide sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-305 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 25 sections |
| CHLOROTHIAZIDE SODIUM | Human Prescription Drug Label | 1 | 47335-330 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 21 sections |
| Chlorothiazide | Human Prescription Drug Label | 1 | 63323-658 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 13 sections |
| Chlorothiazide | Human Prescription Drug Label | 1 | 63323-658 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 13 sections |
| Chlorothiazide | Human Prescription Drug Label | 1 | 63323-658 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 13 sections |
| Chlorothiazide | Human Prescription Drug Label | 1 | 63323-658 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 13 sections |
| Chlorothiazide | Human Prescription Drug Label | 1 | 63323-658 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 13 sections |
| Chlorothiazide | Human Prescription Drug Label | 1 | 63323-658 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 13 sections |
| DIURIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65649-311 | SUSPENSION | 250 mg | ORAL | NDA | 23 sections |
| DIURIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65649-311 | SUSPENSION | 250 mg | ORAL | NDA | 23 sections |
| Sodium Diuril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 76478-711 | INJECTION | 0.50 mg | INTRAVENOUS | NDA | 24 sections |
| Sodium Diuril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 76478-711 | INJECTION | 0.50 mg | INTRAVENOUS | NDA | 24 sections |
| Sodium Diuril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 76478-711 | INJECTION | 0.50 mg | INTRAVENOUS | NDA | 24 sections |