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| Stem definition | Drug id | CAS RN |
|---|---|---|
| quinoline derivatives | 607 | 54-05-7 |
| Dose | Unit | Route |
|---|---|---|
| 0.50 | g | O |
| 0.50 | g | P |
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 50 mg/mL | Bocci G, Oprea TI, Benet LZ |
| EoM (Fraction excreted unchanged in urine) | 61 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 46.89 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 80 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 140 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 4.10 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.43 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 570 hours | Lombardo F, Berellini G, Obach RS |
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT2,AKT3,AXL,BRAF,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,MAP3K21,MAP3K7,MAPK10,MAPK7,MET,NTRK2,PDK2,PDK4,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1 | 35 | |||
| kinase-selectivity-class | AXL,EIF2AK3,PDK4 | 3 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 1.472 | High | 0.87 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pld-class | Phospholipidosis risk class (1 = positive, 0 = negative) | 1 | High | 1 | |
| rat-kpuu-brain | Rat brain Kpuu | 0.180 | % | High | 0.87 |
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 31, 1949 | FDA | SANOFI AVENTIS US |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Blood parathyroid hormone decreased | 135.00 | 17.90 | 51 | 10105 | 12165 | 90606126 |
| Panniculitis | 133.60 | 17.90 | 53 | 10103 | 14405 | 90603886 |
| Granuloma skin | 130.50 | 17.90 | 48 | 10108 | 10632 | 90607659 |
| Treatment failure | 125.51 | 17.90 | 162 | 9994 | 303766 | 90314525 |
| Hepatitis | 124.87 | 17.90 | 85 | 10071 | 70654 | 90547637 |
| Rheumatoid nodule | 116.60 | 17.90 | 53 | 10103 | 20113 | 90598178 |
| Skin necrosis | 115.56 | 17.90 | 50 | 10106 | 16891 | 90601400 |
| Breath sounds abnormal | 113.50 | 17.90 | 48 | 10108 | 15338 | 90602953 |
| Necrotising herpetic retinopathy | 108.97 | 17.90 | 18 | 10138 | 121 | 90618170 |
| Basal cell carcinoma | 102.12 | 17.90 | 57 | 10099 | 33332 | 90584959 |
| C-reactive protein increased | 91.41 | 17.90 | 107 | 10049 | 181282 | 90437009 |
| Hypercalcaemia | 84.89 | 17.90 | 51 | 10105 | 34189 | 90584102 |
| Ulcer | 84.18 | 17.90 | 50 | 10106 | 32832 | 90585459 |
| Red blood cell sedimentation rate increased | 81.07 | 17.90 | 70 | 10086 | 82525 | 90535766 |
| Skin ulcer | 80.88 | 17.90 | 57 | 10099 | 50018 | 90568273 |
| Aspartate aminotransferase increased | 79.03 | 17.90 | 76 | 10080 | 102861 | 90515430 |
| Drug eruption | 78.24 | 17.90 | 49 | 10107 | 35358 | 90582933 |
| Arthritis | 74.96 | 17.90 | 93 | 10063 | 167222 | 90451069 |
| Skin neoplasm excision | 72.76 | 17.90 | 20 | 10136 | 1726 | 90616565 |
| Pulmonary fibrosis | 72.57 | 17.90 | 74 | 10082 | 107429 | 90510862 |
| Condition aggravated | 71.06 | 17.90 | 185 | 9971 | 595360 | 90022931 |
| Prescribed underdose | 62.55 | 17.90 | 58 | 10098 | 74961 | 90543330 |
| Rheumatoid factor positive | 57.79 | 17.90 | 83 | 10073 | 171567 | 90446724 |
| Central nervous system lymphoma | 56.29 | 17.90 | 17 | 10139 | 2048 | 90616243 |
| Off label use | 54.22 | 17.90 | 255 | 9901 | 1101997 | 89516294 |
| Alanine aminotransferase increased | 53.32 | 17.90 | 66 | 10090 | 118272 | 90500019 |
| Drug tolerance decreased | 52.86 | 17.90 | 37 | 10119 | 32093 | 90586198 |
| Jaw clicking | 50.36 | 17.90 | 9 | 10147 | 101 | 90618190 |
| Dermatitis | 49.70 | 17.90 | 31 | 10125 | 22189 | 90596102 |
| Weber tuning fork test abnormal | 49.65 | 17.90 | 9 | 10147 | 110 | 90618181 |
| Deafness | 49.33 | 17.90 | 31 | 10125 | 22483 | 90595808 |
| Atrioventricular block complete | 48.06 | 17.90 | 23 | 10133 | 9788 | 90608503 |
| Inflammation | 46.92 | 17.90 | 77 | 10079 | 178515 | 90439776 |
| Neoplasm skin | 45.43 | 17.90 | 16 | 10140 | 3126 | 90615165 |
| Retinal toxicity | 44.39 | 17.90 | 13 | 10143 | 1409 | 90616882 |
| Synovitis | 43.96 | 17.90 | 107 | 10049 | 329645 | 90288646 |
| Rash pruritic | 42.18 | 17.90 | 49 | 10107 | 82165 | 90536126 |
| Musculoskeletal stiffness | 41.43 | 17.90 | 98 | 10058 | 296434 | 90321857 |
| Therapeutic product effect incomplete | 41.04 | 17.90 | 76 | 10080 | 193820 | 90424471 |
| Drug ineffective | 38.88 | 17.90 | 276 | 9880 | 1384022 | 89234269 |
| Drug intolerance | 37.75 | 17.90 | 123 | 10033 | 447468 | 90170823 |
| Loss of personal independence in daily activities | 37.53 | 17.90 | 60 | 10096 | 136045 | 90482246 |
| Hepatitis viral | 34.43 | 17.90 | 9 | 10147 | 641 | 90617650 |
| Hepatic enzyme increased | 33.95 | 17.90 | 103 | 10053 | 360633 | 90257658 |
| Amaurosis | 32.25 | 17.90 | 9 | 10147 | 821 | 90617470 |
| Varicella zoster virus infection | 31.62 | 17.90 | 13 | 10143 | 3864 | 90614427 |
| Cutaneous leishmaniasis | 30.67 | 17.90 | 6 | 10150 | 113 | 90618178 |
| Secondary adrenocortical insufficiency | 30.47 | 17.90 | 11 | 10145 | 2307 | 90615984 |
| Hypersensitivity | 29.77 | 17.90 | 115 | 10041 | 454562 | 90163729 |
| Maculopathy | 29.63 | 17.90 | 11 | 10145 | 2495 | 90615796 |
| Therapeutic response decreased | 28.15 | 17.90 | 42 | 10114 | 89687 | 90528604 |
| Drug tolerance | 28.00 | 17.90 | 20 | 10136 | 17896 | 90600395 |
| Petechiae | 27.94 | 17.90 | 19 | 10137 | 15722 | 90602569 |
| Attention deficit hyperactivity disorder | 27.38 | 17.90 | 12 | 10144 | 4172 | 90614119 |
| Disseminated tuberculosis | 26.70 | 17.90 | 11 | 10145 | 3288 | 90615003 |
| Acquired pigmented retinopathy | 26.60 | 17.90 | 4 | 10152 | 13 | 90618278 |
| Ventricular hypertrophy | 26.41 | 17.90 | 11 | 10145 | 3380 | 90614911 |
| Erythema | 25.96 | 17.90 | 70 | 10086 | 229176 | 90389115 |
| Ocular toxicity | 25.68 | 17.90 | 8 | 10148 | 1069 | 90617222 |
| Muscle contracture | 25.29 | 17.90 | 9 | 10147 | 1812 | 90616479 |
| Interferon gamma release assay positive | 25.04 | 17.90 | 5 | 10151 | 105 | 90618186 |
| Contraindicated product administered | 24.32 | 17.90 | 85 | 10071 | 320054 | 90298237 |
| Insomnia | 24.01 | 17.90 | 87 | 10069 | 333387 | 90284904 |
| Diarrhoea | 23.95 | 17.90 | 43 | 10113 | 939147 | 89679144 |
| Rheumatoid arthritis | 23.94 | 17.90 | 92 | 10064 | 362522 | 90255769 |
| Mucocutaneous leishmaniasis | 23.41 | 17.90 | 6 | 10150 | 395 | 90617896 |
| Oral mucosa erosion | 23.13 | 17.90 | 8 | 10148 | 1481 | 90616810 |
| Carcinoembryonic antigen increased | 23.05 | 17.90 | 9 | 10147 | 2341 | 90615950 |
| Type V hyperlipidaemia | 22.88 | 17.90 | 7 | 10149 | 881 | 90617410 |
| Pneumonia | 22.50 | 17.90 | 135 | 10021 | 637924 | 89980367 |
| Areflexia | 22.37 | 17.90 | 10 | 10146 | 3643 | 90614648 |
| Drug ineffective for unapproved indication | 22.06 | 17.90 | 32 | 10124 | 66612 | 90551679 |
| Gastrointestinal disorder | 22.00 | 17.90 | 71 | 10085 | 256616 | 90361675 |
| Toxic encephalopathy | 21.66 | 17.90 | 13 | 10143 | 8686 | 90609605 |
| Cinchonism | 21.00 | 17.90 | 3 | 10153 | 6 | 90618285 |
| Cardiotoxicity | 20.82 | 17.90 | 14 | 10142 | 11375 | 90606916 |
| Nerve degeneration | 20.78 | 17.90 | 4 | 10152 | 69 | 90618222 |
| Hypertension | 20.26 | 17.90 | 103 | 10053 | 457429 | 90160862 |
| Dyslipidaemia | 19.87 | 17.90 | 13 | 10143 | 10094 | 90608197 |
| Restrictive cardiomyopathy | 19.50 | 17.90 | 5 | 10151 | 330 | 90617961 |
| Hepatic pain | 19.36 | 17.90 | 9 | 10147 | 3586 | 90614705 |
| Constipation | 19.21 | 17.90 | 4 | 10152 | 280391 | 90337900 |
| Product use issue | 18.81 | 17.90 | 80 | 10076 | 329839 | 90288452 |
| Therapeutic product effect decreased | 17.96 | 17.90 | 70 | 10086 | 277501 | 90340790 |
| Glomerulonephritis chronic | 17.93 | 17.90 | 4 | 10152 | 145 | 90618146 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Off label use | 210.98 | 28.35 | 198 | 1828 | 638137 | 41981172 |
| Maculopathy | 42.84 | 28.35 | 10 | 2016 | 1065 | 42618244 |
| Pneumococcal infection | 37.77 | 28.35 | 8 | 2018 | 546 | 42618763 |
| Dry gangrene | 32.74 | 28.35 | 7 | 2019 | 500 | 42618809 |
| Malaria | 32.19 | 28.35 | 6 | 2020 | 212 | 42619097 |
| Rales | 28.89 | 28.35 | 13 | 2013 | 11387 | 42607922 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Off label use | 171.65 | 17.93 | 436 | 11062 | 1499749 | 109078052 |
| Blood parathyroid hormone decreased | 135.28 | 17.93 | 51 | 11447 | 13038 | 110564763 |
| Granuloma skin | 131.42 | 17.93 | 48 | 11450 | 11235 | 110566566 |
| Panniculitis | 130.11 | 17.93 | 52 | 11446 | 15530 | 110562271 |
| Rheumatoid nodule | 120.07 | 17.93 | 53 | 11445 | 20243 | 110557558 |
| Treatment failure | 118.67 | 17.93 | 145 | 11353 | 277089 | 110300712 |
| Hepatitis | 107.71 | 17.93 | 83 | 11415 | 89971 | 110487830 |
| Skin necrosis | 107.69 | 17.93 | 50 | 11448 | 21462 | 110556339 |
| Necrotising herpetic retinopathy | 104.23 | 17.93 | 18 | 11480 | 177 | 110577624 |
| Breath sounds abnormal | 93.93 | 17.93 | 48 | 11450 | 25356 | 110552445 |
| Basal cell carcinoma | 85.03 | 17.93 | 55 | 11443 | 45215 | 110532586 |
| C-reactive protein increased | 83.63 | 17.93 | 108 | 11390 | 217811 | 110359990 |
| Pulmonary fibrosis | 76.65 | 17.93 | 72 | 11426 | 101970 | 110475831 |
| Red blood cell sedimentation rate increased | 76.24 | 17.93 | 64 | 11434 | 78238 | 110499563 |
| Ulcer | 75.16 | 17.93 | 50 | 11448 | 43066 | 110534735 |
| Hypercalcaemia | 73.93 | 17.93 | 51 | 11447 | 46606 | 110531195 |
| Prescribed underdose | 73.42 | 17.93 | 58 | 11440 | 65116 | 110512685 |
| Skin ulcer | 72.47 | 17.93 | 57 | 11441 | 63588 | 110514213 |
| Arthritis | 72.16 | 17.93 | 88 | 11410 | 167498 | 110410303 |
| Rheumatoid factor positive | 71.61 | 17.93 | 78 | 11420 | 131562 | 110446239 |
| Skin neoplasm excision | 70.98 | 17.93 | 20 | 11478 | 2038 | 110575763 |
| Drug eruption | 65.32 | 17.93 | 50 | 11448 | 53609 | 110524192 |
| Maculopathy | 63.37 | 17.93 | 20 | 11478 | 3007 | 110574794 |
| Drug tolerance decreased | 60.59 | 17.93 | 37 | 11461 | 27503 | 110550298 |
| Aspartate aminotransferase increased | 59.35 | 17.93 | 78 | 11420 | 159858 | 110417943 |
| Condition aggravated | 59.15 | 17.93 | 189 | 11309 | 734647 | 109843154 |
| Atrioventricular block complete | 57.47 | 17.93 | 32 | 11466 | 20050 | 110557751 |
| Jaw clicking | 51.53 | 17.93 | 9 | 11489 | 95 | 110577706 |
| Central nervous system lymphoma | 51.05 | 17.93 | 17 | 11481 | 3027 | 110574774 |
| Weber tuning fork test abnormal | 50.32 | 17.93 | 9 | 11489 | 110 | 110577691 |
| Inflammation | 48.04 | 17.93 | 78 | 11420 | 193160 | 110384641 |
| Deafness | 46.60 | 17.93 | 31 | 11467 | 26678 | 110551123 |
| Neoplasm skin | 46.29 | 17.93 | 16 | 11482 | 3188 | 110574613 |
| Dermatitis | 45.44 | 17.93 | 31 | 11467 | 27806 | 110549995 |
| Synovitis | 43.32 | 17.93 | 91 | 11407 | 274001 | 110303800 |
| Acquired pigmented retinopathy | 41.81 | 17.93 | 6 | 11492 | 14 | 110577787 |
| Drug ineffective | 41.16 | 17.93 | 284 | 11214 | 1520256 | 109057545 |
| Alanine aminotransferase increased | 40.11 | 17.93 | 70 | 11428 | 183703 | 110394098 |
| Therapeutic product effect incomplete | 38.54 | 17.93 | 77 | 11421 | 223728 | 110354073 |
| Rash pruritic | 38.18 | 17.93 | 49 | 11449 | 98020 | 110479781 |
| Loss of personal independence in daily activities | 37.88 | 17.93 | 61 | 11437 | 149959 | 110427842 |
| Musculoskeletal stiffness | 34.29 | 17.93 | 84 | 11414 | 279738 | 110298063 |
| Hypersensitivity | 33.38 | 17.93 | 105 | 11393 | 403893 | 110173908 |
| Drug intolerance | 32.99 | 17.93 | 105 | 11393 | 406407 | 110171394 |
| Hepatic enzyme increased | 32.82 | 17.93 | 90 | 11408 | 320802 | 110256999 |
| Contraindicated product administered | 31.99 | 17.93 | 76 | 11422 | 248191 | 110329610 |
| Restrictive cardiomyopathy | 30.73 | 17.93 | 9 | 11489 | 1052 | 110576749 |
| Cardiotoxicity | 30.43 | 17.93 | 20 | 11478 | 16861 | 110560940 |
| Insomnia | 29.12 | 17.93 | 93 | 11405 | 360497 | 110217304 |
| Drug tolerance | 28.33 | 17.93 | 19 | 11479 | 16566 | 110561235 |
| Hepatitis viral | 27.81 | 17.93 | 9 | 11489 | 1466 | 110576335 |
| Arthropathy | 27.77 | 17.93 | 79 | 11419 | 287443 | 110290358 |
| Joint swelling | 27.76 | 17.93 | 105 | 11393 | 442740 | 110135061 |
| Plasmodium vivax infection | 27.68 | 17.93 | 4 | 11494 | 10 | 110577791 |
| Attention deficit hyperactivity disorder | 27.43 | 17.93 | 12 | 11486 | 4479 | 110573322 |
| Amaurosis | 27.15 | 17.93 | 9 | 11489 | 1580 | 110576221 |
| Therapeutic product effect decreased | 26.45 | 17.93 | 70 | 11428 | 244246 | 110333555 |
| Varicella zoster virus infection | 26.37 | 17.93 | 13 | 11485 | 6355 | 110571446 |
| Therapeutic response decreased | 25.39 | 17.93 | 40 | 11458 | 96459 | 110481342 |
| Cinchonism | 25.05 | 17.93 | 4 | 11494 | 23 | 110577778 |
| Electrocardiogram QT prolonged | 24.40 | 17.93 | 42 | 11456 | 108918 | 110468883 |
| Secondary adrenocortical insufficiency | 24.36 | 17.93 | 11 | 11487 | 4423 | 110573378 |
| Cutaneous leishmaniasis | 23.95 | 17.93 | 6 | 11492 | 389 | 110577412 |
| Diarrhoea | 23.85 | 17.93 | 52 | 11446 | 1139453 | 109438348 |
| Drug ineffective for unapproved indication | 23.51 | 17.93 | 40 | 11458 | 102798 | 110475003 |
| Malaria | 23.48 | 17.93 | 6 | 11492 | 421 | 110577380 |
| Hypertension | 23.43 | 17.93 | 110 | 11388 | 509974 | 110067827 |
| Oral mucosa erosion | 23.35 | 17.93 | 9 | 11489 | 2439 | 110575362 |
| Disseminated tuberculosis | 22.80 | 17.93 | 11 | 11487 | 5135 | 110572666 |
| Petechiae | 22.56 | 17.93 | 19 | 11479 | 23298 | 110554503 |
| Constipation | 22.21 | 17.93 | 5 | 11493 | 357781 | 110220020 |
| Mucocutaneous leishmaniasis | 22.19 | 17.93 | 6 | 11492 | 525 | 110577276 |
| Muscle contracture | 22.15 | 17.93 | 9 | 11489 | 2799 | 110575002 |
| Pneumococcal infection | 22.15 | 17.93 | 8 | 11490 | 1811 | 110575990 |
| Dry gangrene | 22.15 | 17.93 | 7 | 11491 | 1057 | 110576744 |
| Carcinoembryonic antigen increased | 22.10 | 17.93 | 9 | 11489 | 2815 | 110574986 |
| Product use issue | 21.27 | 17.93 | 76 | 11422 | 311619 | 110266182 |
| Product use in unapproved indication | 20.92 | 17.93 | 97 | 11401 | 447280 | 110130521 |
| Anaemia | 20.66 | 17.93 | 16 | 11482 | 547070 | 110030731 |
| Death | 20.04 | 17.93 | 26 | 11472 | 698843 | 109878958 |
| Areflexia | 19.95 | 17.93 | 11 | 11487 | 6758 | 110571043 |
| Type V hyperlipidaemia | 19.87 | 17.93 | 7 | 11491 | 1475 | 110576326 |
| Ventricular hypertrophy | 19.54 | 17.93 | 11 | 11487 | 7034 | 110570767 |
| Gastrointestinal disorder | 19.14 | 17.93 | 62 | 11436 | 241890 | 110335911 |
| Retinal toxicity | 19.10 | 17.93 | 7 | 11491 | 1652 | 110576149 |
| Erythema | 18.98 | 17.93 | 70 | 11428 | 291377 | 110286424 |
| Hypotension | 18.93 | 17.93 | 16 | 11482 | 523833 | 110053968 |
None
| Source | Code | Description |
|---|---|---|
| ATC | P01BA01 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTIPROTOZOALS ANTIMALARIALS Aminoquinolines |
| ATC | P01BB52 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTIPROTOZOALS ANTIMALARIALS Biguanides |
| FDA EPC | N0000175482 | Antimalarial |
| CHEBI has role | CHEBI:22587 | antiviral agent |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:35842 | antirheumatic drug |
| CHEBI has role | CHEBI:38068 | antimalarial |
| CHEBI has role | CHEBI:50177 | dermatologic drug |
| CHEBI has role | CHEBI:64946 | anti-HIV agent |
| CHEBI has role | CHEBI:75835 | anti-anaemic agent |
| CHEBI has role | CHEBI:88230 | autophagy inhibitor |
| CHEBI has role | CHEBI:149553 | anticoronaviral agent |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D000871 | Anthelmintics |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
| MeSH PA | D000962 | Antimalarials |
| MeSH PA | D000969 | Antinematodal Agents |
| MeSH PA | D000977 | Antiparasitic Agents |
| MeSH PA | D000981 | Antiprotozoal Agents |
| MeSH PA | D005369 | Filaricides |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018501 | Antirheumatic Agents |
| MeSH PA | D018689 | Sensory System Agents |
| MeSH PA | D018712 | Analgesics, Non-Narcotic |
| MeSH PA | D000563 | Amebicides |
| CHEBI has role | CHEBI:38070 | anti-arrhythmia drug |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Ovale malaria | indication | 19341001 | DOID:12919 |
| Vivax malaria | indication | 27052006 | DOID:12978 |
| Quartan malaria | indication | 27618009 | DOID:14324 |
| Systemic lupus erythematosus | indication | 55464009 | DOID:9074 |
| Falciparum malaria | indication | 62676009 | DOID:14067 |
| Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
| Discoid lupus erythematosus | indication | 200938002 | |
| Plasmodium Malariae Malaria Prevention | indication | ||
| Plasmodium Ovale Malaria Prevention | indication | ||
| Malaria Prevention | indication | ||
| Plasmodium Falciparum Malaria Prevention | indication | ||
| Vasculitis of the skin | off-label use | 53312001 | |
| Porphyria cutanea tarda | off-label use | 61860000 | DOID:3132 |
| Q fever endocarditis | off-label use | 95890006 | |
| Coronavirus infection | off-label use | 186747009 | |
| Polymorphic light eruption | off-label use | 238525001 | |
| Juvenile rheumatoid arthritis | off-label use | 410795001 | |
| Hypercalcemia associated with Sarcoidosis | off-label use | ||
| Alcoholism | contraindication | 7200002 | |
| Psoriasis | contraindication | 9014002 | DOID:8893 |
| Visual field defect | contraindication | 12184005 | |
| Retinal disorder | contraindication | 29555009 | DOID:5679 |
| Leukopenia | contraindication | 84828003 | DOID:615 |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
| Hearing disorder | contraindication | 128540005 | |
| Seizure disorder | contraindication | 128613002 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Anemia | contraindication | 271737000 | DOID:2355 |
| Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
| Disorder of macula of retina | contraindication | 312999006 | |
| Disorder of eye | contraindication | 371405004 | DOID:5614 |
| Visual impairment | contraindication | 397540003 | |
| Porphyria | contraindication | 418470004 |
| Species | Use | Relation |
|---|---|---|
| Dogs | Euthanasia | Indication |
| Product | Applicant | Ingredients |
|---|---|---|
| Tributame Euthanasia Solution | Cronus Pharma Specialities India Private Limited | 3 |
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.19 | Basic |
| pKa2 | 7.83 | Basic |
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor | GPCR | Ki | 5.36 | CHEMBL | |||||
| Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 7.10 | CHEMBL | |||||
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.60 | WOMBAT-PK | |||||
| Alpha-2B adrenergic receptor | GPCR | Ki | 4.50 | CHEMBL | |||||
| Muscarinic acetylcholine receptor M1 | GPCR | Ki | 5.04 | CHEMBL | |||||
| Muscarinic acetylcholine receptor M2 | GPCR | Ki | 5.33 | CHEMBL | |||||
| Muscarinic acetylcholine receptor M3 | GPCR | Ki | 5.48 | CHEMBL | |||||
| Muscarinic acetylcholine receptor M4 | GPCR | Ki | 5.24 | CHEMBL | |||||
| Muscarinic acetylcholine receptor M5 | GPCR | Ki | 4.66 | CHEMBL | |||||
| Alpha-2C adrenergic receptor | GPCR | Ki | 5 | CHEMBL | |||||
| Ribosyldihydronicotinamide dehydrogenase [quinone] | Enzyme | IC50 | 5.82 | CHEMBL | |||||
| Serine/threonine-protein kinase mTOR | Kinase | IC50 | 6.57 | CHEMBL | |||||
| C-X-C chemokine receptor type 4 | GPCR | EC50 | 5.19 | CHEMBL | |||||
| Beta-secretase 1 | Enzyme | IC50 | 5.16 | CHEMBL | |||||
| Major prion protein | Surface antigen | EC50 | 5.40 | CHEMBL | |||||
| Amyloid beta A4 protein | Membrane other | IC50 | 5.16 | CHEMBL | |||||
| Transmembrane protein 97 | Enzyme | Ki | 6.30 | CHEMBL | |||||
| Nuclear receptor subfamily 4 group A member 2 | Nuclear other | EC50 | 4.33 | CHEMBL | |||||
| Histidine-rich protein PFHRP-II | Cytosolic other | IC50 | 6.40 | CHEMBL | |||||
| Riboflavin-binding protein | Secreted | Kd | 5.68 | CHEMBL | |||||
| Dihydrofolate reductase | Enzyme | IC50 | 7.52 | CHEMBL | |||||
| Replicase polyprotein 1ab | Enzyme | IC50 | 5.14 | CHEMBL | |||||
| Spike glycoprotein | Glycoprotein | IC50 | 6.80 | CHEMBL | |||||
| Cysteine proteinase falcipain 2a | Enzyme | IC50 | 7.70 | CHEMBL | |||||
| NACHT, LRR and PYD domains-containing protein 3 | Cytosolic other | IC50 | 4.06 | CHEMBL | |||||
| Cysteine proteinase falcipain 2a | Enzyme | IC50 | 6.70 | CHEMBL |
| ID | Source |
|---|---|
| D02125 | KEGG_DRUG |
| 132-73-0 | SECONDARY_CAS_RN |
| 50-63-5 | SECONDARY_CAS_RN |
| 203119 | RXNORM |
| C0008269 | UMLSCUI |
| CHEBI:3638 | CHEBI |
| CLQ | PDB_CHEM_ID |
| CHEMBL76 | ChEMBL_ID |
| CHEMBL2095223 | ChEMBL_ID |
| CHEMBL58510 | ChEMBL_ID |
| DB00608 | DRUGBANK_ID |
| CHEMBL4297165 | ChEMBL_ID |
| D002738 | MESH_DESCRIPTOR_UI |
| 2719 | PUBCHEM_CID |
| 5535 | IUPHAR_LIGAND_ID |
| 386 | INN_ID |
| 3545-67-3 | SECONDARY_CAS_RN |
| 886U3H6UFF | UNII |
| 3949 | MMSL |
| 4417 | MMSL |
| 4418 | MMSL |
| d00035 | MMSL |
| 002938 | NDDF |
| 002939 | NDDF |
| 002940 | NDDF |
| 004124 | NDDF |
| 14728000 | SNOMEDCT_US |
| 373468005 | SNOMEDCT_US |
| 395937005 | SNOMEDCT_US |
| 53136009 | SNOMEDCT_US |
| 60266005 | SNOMEDCT_US |
| 4018227 | VANDF |
| 4018228 | VANDF |
| 4019675 | VANDF |
| C023676 | MESH_SUPPLEMENTAL_RECORD_UI |
| 886U3H6UFF | INXIGHT DRUGS |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Chloroquine Phosphate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-2790 | TABLET | 250 mg | ORAL | ANDA | 20 sections |
| Chloroquine Phosphate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-7010 | TABLET | 500 mg | ORAL | ANDA | 20 sections |
| Chloroquine Phosphate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-850 | TABLET, COATED | 500 mg | ORAL | ANDA | 22 sections |
| Chloroquine Phosphate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-047 | TABLET | 500 mg | ORAL | ANDA | 20 sections |
| CHLOROQUINE PHOSPHATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62135-717 | TABLET, COATED | 500 mg | ORAL | ANDA | 12 sections |
| Chloroquine Phosphate | Human Prescription Drug Label | 1 | 64980-177 | TABLET | 250 mg | ORAL | ANDA | 14 sections |
| Chloroquine Phosphate | Human Prescription Drug Label | 1 | 64980-178 | TABLET | 500 mg | ORAL | ANDA | 15 sections |