DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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Structure 🔎
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
Scroll
All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
chlorcyclizine 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
diphenylmethyl piperazine derivatives
593
82-93-9
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
chlorcyclizine
chlorcycline
chlorocycline
perazyl
chlorcyclizine hydrochloride
chlorcyclizine HCl
Molecular weight: 300.83
Formula: C18H21ClN2
CLOGP: 4.51
LIPINSKI: 0
HAC: 2
HDO: 0
TPSA: 6.48
ALOGS: -3.85
ROTB: 3
Drug dosage:
Dose
Unit
Route
0.10
g
O
ADMET properties:
None
Approvals:
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Date
Agency
Company
Orphan
None
FDA
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
R06AE04
RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Piperazine derivatives
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Vasomotor rhinitis
indication
8229003
DOID:4730
Cough
indication
49727002
Allergic rhinitis
indication
61582004
Nasal discharge
indication
64531003
Nasal congestion
indication
68235000
Sneezing
indication
76067001
Common cold
indication
82272006
DOID:10459
Seasonal allergic rhinitis
indication
367498001
Allergic conjunctivitis
indication
473460002
DOID:11204
Ocular hypertension
contraindication
4210003
DOID:9282
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
8.19
Basic
pKa2
3.56
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Apoptosis regulator Bcl-2
Cytosolic other
P10415
BCL2_HUMAN
Kd
4.22
CHEMBL
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External reference:
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entries
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ID
Source
003398
NDDF
003399
NDDF
11602
MMSL
1301
INN_ID
14362-31-3
SECONDARY_CAS_RN
2354
RXNORM
2710
PUBCHEM_CID
4018770
VANDF
4019672
VUID
4019672
VANDF
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Pharmaceutical products:
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Product
Category
Ingredients
NDC
Form
Quantity
Route
Marketing
Label
AHIST
HUMAN OTC DRUG LABEL
1
58407-025
TABLET
25 mg
ORAL
OTC monograph final
14 sections
AHIST
HUMAN OTC DRUG LABEL
1
58407-025
TABLET
25 mg
ORAL
OTC monograph final
14 sections
biclora
HUMAN OTC DRUG LABEL
2
54868-6381
LIQUID
12.50 mg
ORAL
OTC monograph final
14 sections
BonineKids
HUMAN OTC DRUG LABEL
1
63736-044
TABLET, CHEWABLE
25 mg
ORAL
OTC monograph final
26 sections
STAHIST AD
HUMAN OTC DRUG LABEL
2
58407-625
TABLET
25 mg
ORAL
OTC monograph final
16 sections
STAHIST AD
HUMAN OTC DRUG LABEL
2
58407-625
TABLET
25 mg
ORAL
OTC monograph final
16 sections
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Structure 🔎
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L1000
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chlorcyclizine