DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
Scroll
All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
buclizine 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
diphenylmethyl piperazine derivatives
416
82-95-1
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
buclizine
buclifen
histabuticine
histabutizine
histabutyzine
hitabutyzyne
buclizine hydrochloride
buclizine HCl
Molecular weight: 433.04
Formula: C28H33ClN2
CLOGP: 8.06
LIPINSKI: 1
HAC: 2
HDO: 0
TPSA: 6.48
ALOGS: -6.25
ROTB: 6
Status: OFM
Legend:
OFP - off patent
OFM - off market
ONP - on patent
Drug dosage:
Dose
Unit
Route
50
mg
O
ADMET properties:
None
Approvals:
Show
10
25
50
100
entries
Search:
Date
Agency
Company
Orphan
None
FDA
STUART PHARMS
Showing 1 to 1 of 1 entries
Previous
1
Next
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
Show
10
25
50
100
entries
Search:
Source
Code
Description
ATC
R06AE01
RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Piperazine derivatives
ATC
R06AE51
RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Piperazine derivatives
CHEBI has role
CHEBI:35488
central nervous system depressants
CHEBI has role
CHEBI:36333
local anesthetics
CHEBI has role
CHEBI:37956
antihistamines
CHEBI has role
CHEBI:48873
acetylcholine receptor antagonist
CHEBI has role
CHEBI:50919
antiemetico
MeSH PA
D018494
Histamine Agents
MeSH PA
D006633
Histamine Antagonists
MeSH PA
D018377
Neurotransmitter Agents
Showing 1 to 10 of 10 entries
Previous
1
Next
Drug Use
| Suggest Off label Use Form|
|View source of the data|
Show
10
25
50
100
entries
Search:
Disease
Relation
SNOMED_ID
DOID
Motion sickness
indication
37031009
DOID:2951
Showing 1 to 1 of 1 entries
Previous
1
Next
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
Show
10
25
50
100
entries
Search:
Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
7.15
Basic
pKa2
3.15
Basic
Showing 1 to 2 of 2 entries
Previous
1
Next
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
Show
10
25
50
100
entries
Search:
Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Histamine H1 receptor
GPCR
P35367
HRH1_HUMAN
ANTAGONIST
CHEMBL
CHEMBL
Showing 1 to 1 of 1 entries
Previous
1
Next
External reference:
Show
10
25
50
100
entries
Search:
ID
Source
003404
NDDF
004801
NDDF
0C94V6X681
UNII
129-74-8
SECONDARY_CAS_RN
1956002
SNOMEDCT_US
291
INN_ID
387344005
SNOMEDCT_US
4018463
VANDF
4019642
VUID
4019642
VANDF
Showing 1 to 10 of 23 entries
Previous
1
2
3
Next
Pharmaceutical products:
None
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
buclizine