Stem definition | Drug id | CAS RN |
---|---|---|
58 | 546-88-3 |
Dose | Unit | Route |
---|---|---|
0.75 | g | O |
Property | Value | Reference |
---|---|---|
BA (Bioavailability) | 55 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
May 31, 1983 | FDA | MISSION PHARMA |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | G04BX03 | GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS UROLOGICALS Other urologicals |
FDA MoA | N0000175087 | Urease Inhibitors |
MeSH PA | D004791 | Enzyme Inhibitors |
FDA EPC | N0000175611 | Urease Inhibitor |
CHEBI has role | CHEBI:50635 | urea amidohydrolase inhibitor |
CHEBI has role | CHEBI:84735 | algal metabolites |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Urinary tract infectious disease | indication | 68566005 | |
Struvite Renal Calculi | indication | ||
Alcoholism | contraindication | 7200002 | |
Acute nephropathy | contraindication | 58574008 | |
Hemolytic anemia | contraindication | 61261009 | DOID:583 |
Phlebitis | contraindication | 61599003 | DOID:864 |
Leukopenia | contraindication | 84828003 | DOID:615 |
Anemia | contraindication | 271737000 | DOID:2355 |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.38 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Carbonic anhydrase 2 | Enzyme | IC50 | 4.33 | CHEMBL | |||||
Bacterial urease | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
Urease | Enzyme | IC50 | 4.76 | CHEMBL | |||||
Urease subunit beta | Enzyme | IC50 | 4.76 | CHEMBL |
ID | Source |
---|---|
4RZ82L2GY5 | UNII |
4018901 | VUID |
N0000147195 | NUI |
D00220 | KEGG_DRUG |
16728 | RXNORM |
C0050451 | UMLSCUI |
CHEBI:27777 | CHEBI |
HAE | PDB_CHEM_ID |
CHEMBL734 | ChEMBL_ID |
1990 | PUBCHEM_CID |
DB00551 | DRUGBANK_ID |
5491 | INN_ID |
C006358 | MESH_SUPPLEMENTAL_RECORD_UI |
387426003 | SNOMEDCT_US |
74819009 | SNOMEDCT_US |
4018901 | VANDF |
4124 | MMSL |
d01433 | MMSL |
001242 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Lithostat | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0178-0500 | TABLET | 250 mg | ORAL | NDA | 18 sections |
Lithostat | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0178-0500 | TABLET | 250 mg | ORAL | NDA | 18 sections |