acetohydroxamic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	58	546-88-3

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

acetohydroxamic acid
acetohydroximic acid
acetylhydroxamic acid
N-acetylhydroxylamine
N-hydroxyacetamide
N-Acetyl hydroxyacetamide

urease inhibitor

Molecular weight: 75.07
Formula: C2H5NO2
CLOGP: -1.59
LIPINSKI: 0
HAC: 3
HDO: 2
TPSA: 49.33
ALOGS: 0.83
ROTB: 0

Drug dosage:

Dose	Unit	Route
0.75	g	O

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	55 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
May 31, 1983	FDA	MISSION PHARMA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	G04BX03	GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS UROLOGICALS Other urologicals
FDA MoA	N0000175087	Urease Inhibitors
MeSH PA	D004791	Enzyme Inhibitors
FDA EPC	N0000175611	Urease Inhibitor
CHEBI has role	CHEBI:50635	urea amidohydrolase inhibitor
CHEBI has role	CHEBI:84735	algal metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Urinary tract infectious disease	indication	68566005
Struvite Renal Calculi	indication
Alcoholism	contraindication	7200002
Acute nephropathy	contraindication	58574008
Hemolytic anemia	contraindication	61261009	DOID:583
Phlebitis	contraindication	61599003	DOID:864
Leukopenia	contraindication	84828003	DOID:615
Anemia	contraindication	271737000	DOID:2355
Pregnancy, function	contraindication	289908002
Thrombocytopenic disorder	contraindication	302215000	DOID:1588

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.38	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN		IC50	4.33		CHEMBL
Bacterial urease	Enzyme		URE3_ECOLX URE2_ECOLX URE1_ECOLX	INHIBITOR				CHEMBL	CHEMBL
Urease	Enzyme		UREA_CANEN		IC50	4.76		CHEMBL
Urease subunit beta	Enzyme		Q0PXQ5_HELPX		IC50	4.76		CHEMBL

External reference:

ID	Source
4RZ82L2GY5	UNII
4018901	VUID
N0000147195	NUI
D00220	KEGG_DRUG
16728	RXNORM
C0050451	UMLSCUI
CHEBI:27777	CHEBI
HAE	PDB_CHEM_ID
CHEMBL734	ChEMBL_ID
1990	PUBCHEM_CID
DB00551	DRUGBANK_ID
5491	INN_ID
C006358	MESH_SUPPLEMENTAL_RECORD_UI
387426003	SNOMEDCT_US
74819009	SNOMEDCT_US
4018901	VANDF
4124	MMSL
d01433	MMSL
001242	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Lithostat	HUMAN PRESCRIPTION DRUG LABEL	1	0178-0500	TABLET	250 mg	ORAL	NDA	18 sections
Lithostat	HUMAN PRESCRIPTION DRUG LABEL	1	0178-0500	TABLET	250 mg	ORAL	NDA	18 sections