chloral hydrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 586 | 302-17-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A hypnotic and sedative used in the treatment of INSOMNIA.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1 | g | O |
| 1 | g | R |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 8300 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 86.37 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 1, 1840 | YEAR INTRODUCED |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hypomania | 396.83 | 117.50 | 72 | 1168 | 4433 | 50599451 |
| Jaundice cholestatic | 381.35 | 117.50 | 71 | 1169 | 5040 | 50598844 |
| Schizophrenia | 361.19 | 117.50 | 72 | 1168 | 7325 | 50596559 |
| Psychotic disorder | 268.84 | 117.50 | 69 | 1171 | 21743 | 50582141 |
| Hepatotoxicity | 267.82 | 117.50 | 72 | 1168 | 27154 | 50576730 |
| Blood bilirubin increased | 256.22 | 117.50 | 72 | 1168 | 31966 | 50571918 |
| Cholelithiasis | 244.12 | 117.50 | 72 | 1168 | 37901 | 50565983 |
| Hepatic enzyme increased | 156.96 | 117.50 | 73 | 1167 | 137307 | 50466577 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Necrotising enterocolitis neonatal | 56.16 | 51.25 | 8 | 365 | 203 | 29573951 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hypomania | 371.59 | 62.63 | 71 | 1557 | 5583 | 64491521 |
| Jaundice cholestatic | 341.31 | 62.63 | 71 | 1557 | 8599 | 64488505 |
| Schizophrenia | 328.98 | 62.63 | 72 | 1556 | 11096 | 64486008 |
| Psychotic disorder | 243.72 | 62.63 | 71 | 1557 | 34507 | 64462597 |
| Hepatotoxicity | 237.88 | 62.63 | 72 | 1556 | 39890 | 64457214 |
| Cholelithiasis | 228.66 | 62.63 | 72 | 1556 | 45434 | 64451670 |
| Blood bilirubin increased | 208.10 | 62.63 | 71 | 1557 | 57482 | 64439622 |
| Hepatic enzyme increased | 161.45 | 62.63 | 74 | 1554 | 129869 | 64367235 |
| Condition aggravated | 91.50 | 62.63 | 75 | 1553 | 372351 | 64124753 |
| Vomiting | 71.68 | 62.63 | 78 | 1550 | 551039 | 63946065 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N05CC01 | NERVOUS SYSTEM PSYCHOLEPTICS HYPNOTICS AND SEDATIVES Aldehydes and derivatives |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D006993 | Hypnotics and Sedatives |
| CHEBI has role | CHEBI:35703 | Xenobiotic |
| CHEBI has role | CHEBI:35717 | hypnotics |
| CHEBI has role | CHEBI:38869 | general anaesthetic |
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| General anesthesia | indication | 50697003 | |
| Insomnia | indication | 193462001 | |
| Sedation | off-label use | 72641008 | |
| Proctitis | contraindication | 3951002 | DOID:3127 |
| Gastritis | contraindication | 4556007 | DOID:4029 |
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Esophagitis | contraindication | 16761005 | DOID:11963 |
| Inflammatory bowel disease | contraindication | 24526004 | DOID:0050589 |
| Acute nephropathy | contraindication | 58574008 | |
| Hepatic failure | contraindication | 59927004 | |
| Substance abuse | contraindication | 66214007 | |
| Acute disease of cardiovascular system | contraindication | 128487001 | |
| Acute intermittent porphyria | contraindication | 234422006 | DOID:3890 |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cattle | General anesthesia | Indication |
| Cattle | Sedation | Indication |
| Horses | General anesthesia | Indication |
| Horses | Sedation | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Chloropent | Zoetis Inc. | 3 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.9 | acidic |
| pKa2 | 13.19 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4017726 | VUID |
| N0000146094 | NUI |
| D00265 | KEGG_DRUG |
| 2344 | RXNORM |
| 4017726 | VANDF |
| C0008161 | UMLSCUI |
| CHEBI:28142 | CHEBI |
| CHEMBL455917 | ChEMBL_ID |
| DB01563 | DRUGBANK_ID |
| D002697 | MESH_DESCRIPTOR_UI |
| 2707 | PUBCHEM_CID |
| 418M5916WG | UNII |
| 3870 | MMSL |
| 4404 | MMSL |
| d00147 | MMSL |
| 001427 | NDDF |
| 273948005 | SNOMEDCT_US |
| 28748001 | SNOMEDCT_US |
Pharmaceutical products:
None