clofedanol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	585	791-35-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: clofedanol chlophedianol chlophedianol hydrochloride clofedanol hydrochloride chlophedianol HCl clofedanol HCl	Molecular weight: 289.80 Formula: C17H20ClNO CLOGP: 3.63 LIPINSKI: 0 HAC: 2 HDO: 1 TPSA: 23.47 ALOGS: -3.67 ROTB: 5 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

clofedanol
chlophedianol
chlophedianol hydrochloride
clofedanol hydrochloride
chlophedianol HCl
clofedanol HCl

Molecular weight: 289.80
Formula: C17H20ClNO
CLOGP: 3.63
LIPINSKI: 0
HAC: 2
HDO: 1
TPSA: 23.47
ALOGS: -3.67
ROTB: 5

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
60	mg	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R05DB10	RESPIRATORY SYSTEM COUGH AND COLD PREPARATIONS COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS Other cough suppressants
CHEBI has role	CHEBI:51177	anti-tussive

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Vasomotor rhinitis	indication	8229003	DOID:4730
Cough	indication	49727002
Allergic rhinitis	indication	61582004
Nasal discharge	indication	64531003
Nasal congestion	indication	68235000
Rhinitis	indication	70076002	DOID:4483
Common cold	indication	82272006	DOID:10459
Ocular hypertension	contraindication	4210003	DOID:9282
Peptic ulcer	contraindication	13200003	DOID:750
Asthenia	contraindication	13791008
Myocardial infarction	contraindication	22298006	DOID:5844
Ventricular tachycardia	contraindication	25569003
Hyperthyroidism	contraindication	34486009	DOID:7998
Acute hepatitis	contraindication	37871000
Hypertensive disorder	contraindication	38341003	DOID:10763
Chronic heart failure	contraindication	48447003
Bradycardia	contraindication	48867003
Acidosis	contraindication	51387008
Coronary arteriosclerosis	contraindication	53741008	DOID:3393
Arterial thrombosis	contraindication	65198009
Arteriosclerotic vascular disease	contraindication	72092001
Diabetes mellitus	contraindication	73211009	DOID:9351
Chronic idiopathic constipation	contraindication	82934008
Partial atrioventricular block	contraindication	195039008
Acute pancreatitis	contraindication	197456007	DOID:2913
Bladder outflow obstruction	contraindication	236645006
Benign prostatic hyperplasia	contraindication	266569009
Retention of urine	contraindication	267064002
Hypoxia	contraindication	389086002
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Disorder of coronary artery	contraindication	414024009
Central nervous system depression	contraindication	418072004
Hypertensive urgency	contraindication	443482000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.31	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4031610	VUID
N0000185378	NUI
D01389	KEGG_DRUG
511-13-7	SECONDARY_CAS_RN
1014329	RXNORM
C0055904	UMLSCUI
CHEBI:135207	CHEBI
CHEMBL1201313	ChEMBL_ID
CHEMBL1200972	ChEMBL_ID
DB04837	DRUGBANK_ID
C010432	MESH_SUPPLEMENTAL_RECORD_UI
7324	IUPHAR_LIGAND_ID
2795	PUBCHEM_CID
18729	MMSL
26794	MMSL
26837	MMSL
d05347	MMSL
003811	NDDF
003812	NDDF
61398007	SNOMEDCT_US
703416003	SNOMEDCT_US
1135	INN_ID
4031610	VANDF
42C50P12AP	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Chlo Tuss	HUMAN OTC DRUG LABEL	3	12830-762	LIQUID	12.50 mg	ORAL	OTC monograph final	16 sections
Chlo Tuss	HUMAN OTC DRUG LABEL	3	12830-762	LIQUID	12.50 mg	ORAL	OTC monograph final	16 sections
Chlo Hist	HUMAN OTC DRUG LABEL	2	12830-864	LIQUID	12.50 mg	ORAL	OTC monograph final	15 sections
Chlo Hist	HUMAN OTC DRUG LABEL	2	12830-864	LIQUID	12.50 mg	ORAL	OTC monograph final	15 sections
ATUSS DA	HUMAN OTC DRUG LABEL	3	15370-140	LIQUID	12.50 mg	ORAL	OTC MONOGRAPH FINAL	17 sections
Ninjacof	HUMAN OTC DRUG LABEL	2	23359-032	SOLUTION	12.50 mg	ORAL	OTC monograph final	12 sections
Ninjacof-A	HUMAN OTC DRUG LABEL	3	23359-033	LIQUID	12.50 mg	ORAL	OTC monograph final	12 sections
Ninjacof-D	HUMAN OTC DRUG LABEL	3	23359-034	LIQUID	12.50 mg	ORAL	OTC monograph final	15 sections
Ninjacof-D	HUMAN OTC DRUG LABEL	3	23359-034	LIQUID	12.50 mg	ORAL	OTC monograph final	15 sections
Kroger Allergy Relief	HUMAN OTC DRUG LABEL	2	30142-773	LIQUID	25 mg	ORAL	OTC monograph final	16 sections
Clophed	HUMAN OTC DRUG LABEL	3	49963-630	LIQUID	12.50 mg	ORAL	OTC monograph final	14 sections
Chlo Hist	HUMAN OTC DRUG LABEL	2	50090-3998	LIQUID	12.50 mg	ORAL	OTC monograph final	15 sections
Poly Hist PD	HUMAN OTC DRUG LABEL	2	50991-222	LIQUID	6.25 mg	ORAL	OTC monograph final	14 sections
biclora	HUMAN OTC DRUG LABEL	2	54868-6381	LIQUID	12.50 mg	ORAL	OTC monograph final	14 sections
ATUSS DA	HUMAN OTC DRUG LABEL	3	58407-252	LIQUID	12.50 mg	ORAL	OTC monograph final	17 sections
Phenagil CH	HUMAN OTC DRUG LABEL	3	58552-323	TABLET	24 mg	ORAL	OTC monograph final	17 sections
Giltuss Allergy Plus	HUMAN OTC DRUG LABEL	3	58552-334	TABLET	24 mg	ORAL	OTC monograph final	16 sections
Giltuss Allergy Plus	HUMAN OTC DRUG LABEL	3	58552-334	TABLET	24 mg	ORAL	OTC monograph final	16 sections
TEXACLEAR FAST ACTING ALLERGY RELIEF	HUMAN OTC DRUG LABEL	2	58809-063	LIQUID	25 mg	ORAL	OTC monograph final	16 sections
TEXACLEAR FAST ACTING ALLERGY RELIEF	HUMAN OTC DRUG LABEL	2	58809-063	LIQUID	25 mg	ORAL	OTC monograph final	16 sections
TexaClear	HUMAN OTC DRUG LABEL	2	58809-186	TABLET	25 mg	ORAL	OTC monograph final	16 sections
TexaClear	HUMAN OTC DRUG LABEL	2	58809-186	TABLET	25 mg	ORAL	OTC monograph final	16 sections
Dayclear Allergy Relief	HUMAN OTC DRUG LABEL	2	58809-211	LIQUID	25 mg	ORAL	OTC monograph final	17 sections
DAYCLEAR ALLERGY RELIEF	HUMAN OTC DRUG LABEL	2	58809-221	TABLET	25 mg	ORAL	OTC monograph final	16 sections
DAYCLEAR ALLERGY RELIEF CHEWABLES	HUMAN OTC DRUG LABEL	2	58809-222	TABLET, CHEWABLE	25 mg	ORAL	OTC monograph final	14 sections
Childrens DayClear Allergy Cough Chewables	HUMAN OTC DRUG LABEL	2	58809-223	TABLET, CHEWABLE	12.50 mg	ORAL	OTC monograph final	14 sections
Texaclear Fast Acting Allergy Relief	HUMAN OTC DRUG LABEL	2	58809-360	LIQUID	25 mg	ORAL	OTC monograph final	15 sections
Texaclear Fast Acting Allergy Relief	HUMAN OTC DRUG LABEL	2	58809-360	LIQUID	25 mg	ORAL	OTC monograph final	15 sections
TexaClear Kids Allergy	HUMAN OTC DRUG LABEL	2	58809-925	LIQUID	12.50 mg	ORAL	OTC monograph final	14 sections
VANACOF	HUMAN OTC DRUG LABEL	3	58809-999	LIQUID	12.50 mg	ORAL	OTC monograph final	16 sections