clofedanol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
585 791-35-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clofedanol
  • chlophedianol
  • chlophedianol hydrochloride
  • clofedanol hydrochloride
  • chlophedianol HCl
  • clofedanol HCl
  • Molecular weight: 289.80
  • Formula: C17H20ClNO
  • CLOGP: 3.63
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 23.47
  • ALOGS: -3.67
  • ROTB: 5

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
60 mg O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R05DB10 RESPIRATORY SYSTEM
COUGH AND COLD PREPARATIONS
COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
Other cough suppressants
CHEBI has role CHEBI:51177 anti-tussive

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Vasomotor rhinitis indication 8229003 DOID:4730
Cough indication 49727002
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Rhinitis indication 70076002 DOID:4483
Common cold indication 82272006 DOID:10459
Ocular hypertension contraindication 4210003 DOID:9282
Peptic ulcer contraindication 13200003 DOID:750
Asthenia contraindication 13791008
Myocardial infarction contraindication 22298006 DOID:5844
Ventricular tachycardia contraindication 25569003
Hyperthyroidism contraindication 34486009 DOID:7998
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Acidosis contraindication 51387008
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Arterial thrombosis contraindication 65198009
Arteriosclerotic vascular disease contraindication 72092001
Diabetes mellitus contraindication 73211009 DOID:9351
Chronic idiopathic constipation contraindication 82934008
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Disorder of coronary artery contraindication 414024009
Central nervous system depression contraindication 418072004
Hypertensive urgency contraindication 443482000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.31 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4031610 VUID
N0000185378 NUI
D01389 KEGG_DRUG
511-13-7 SECONDARY_CAS_RN
1014329 RXNORM
C0055904 UMLSCUI
CHEBI:135207 CHEBI
CHEMBL1201313 ChEMBL_ID
CHEMBL1200972 ChEMBL_ID
DB04837 DRUGBANK_ID
C010432 MESH_SUPPLEMENTAL_RECORD_UI
7324 IUPHAR_LIGAND_ID
2795 PUBCHEM_CID
18729 MMSL
26794 MMSL
26837 MMSL
d05347 MMSL
003811 NDDF
003812 NDDF
61398007 SNOMEDCT_US
703416003 SNOMEDCT_US
1135 INN_ID
4031610 VANDF
42C50P12AP UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Chlo Tuss HUMAN OTC DRUG LABEL 3 12830-762 LIQUID 12.50 mg ORAL OTC monograph final 16 sections
Chlo Tuss HUMAN OTC DRUG LABEL 3 12830-762 LIQUID 12.50 mg ORAL OTC monograph final 16 sections
Chlo Hist HUMAN OTC DRUG LABEL 2 12830-864 LIQUID 12.50 mg ORAL OTC monograph final 15 sections
Chlo Hist HUMAN OTC DRUG LABEL 2 12830-864 LIQUID 12.50 mg ORAL OTC monograph final 15 sections
ATUSS DA HUMAN OTC DRUG LABEL 3 15370-140 LIQUID 12.50 mg ORAL OTC MONOGRAPH FINAL 17 sections
Ninjacof HUMAN OTC DRUG LABEL 2 23359-032 SOLUTION 12.50 mg ORAL OTC monograph final 12 sections
Ninjacof-A HUMAN OTC DRUG LABEL 3 23359-033 LIQUID 12.50 mg ORAL OTC monograph final 12 sections
Ninjacof-D HUMAN OTC DRUG LABEL 3 23359-034 LIQUID 12.50 mg ORAL OTC monograph final 15 sections
Ninjacof-D HUMAN OTC DRUG LABEL 3 23359-034 LIQUID 12.50 mg ORAL OTC monograph final 15 sections
Kroger Allergy Relief HUMAN OTC DRUG LABEL 2 30142-773 LIQUID 25 mg ORAL OTC monograph final 16 sections
Clophed HUMAN OTC DRUG LABEL 3 49963-630 LIQUID 12.50 mg ORAL OTC monograph final 14 sections
Chlo Hist HUMAN OTC DRUG LABEL 2 50090-3998 LIQUID 12.50 mg ORAL OTC monograph final 15 sections
Poly Hist PD HUMAN OTC DRUG LABEL 2 50991-222 LIQUID 6.25 mg ORAL OTC monograph final 14 sections
biclora HUMAN OTC DRUG LABEL 2 54868-6381 LIQUID 12.50 mg ORAL OTC monograph final 14 sections
ATUSS DA HUMAN OTC DRUG LABEL 3 58407-252 LIQUID 12.50 mg ORAL OTC monograph final 17 sections
Phenagil CH HUMAN OTC DRUG LABEL 3 58552-323 TABLET 24 mg ORAL OTC monograph final 17 sections
Giltuss Allergy Plus HUMAN OTC DRUG LABEL 3 58552-334 TABLET 24 mg ORAL OTC monograph final 16 sections
Giltuss Allergy Plus HUMAN OTC DRUG LABEL 3 58552-334 TABLET 24 mg ORAL OTC monograph final 16 sections
TEXACLEAR FAST ACTING ALLERGY RELIEF HUMAN OTC DRUG LABEL 2 58809-063 LIQUID 25 mg ORAL OTC monograph final 16 sections
TEXACLEAR FAST ACTING ALLERGY RELIEF HUMAN OTC DRUG LABEL 2 58809-063 LIQUID 25 mg ORAL OTC monograph final 16 sections
TexaClear HUMAN OTC DRUG LABEL 2 58809-186 TABLET 25 mg ORAL OTC monograph final 16 sections
TexaClear HUMAN OTC DRUG LABEL 2 58809-186 TABLET 25 mg ORAL OTC monograph final 16 sections
Dayclear Allergy Relief HUMAN OTC DRUG LABEL 2 58809-211 LIQUID 25 mg ORAL OTC monograph final 17 sections
DAYCLEAR ALLERGY RELIEF HUMAN OTC DRUG LABEL 2 58809-221 TABLET 25 mg ORAL OTC monograph final 16 sections
DAYCLEAR ALLERGY RELIEF CHEWABLES HUMAN OTC DRUG LABEL 2 58809-222 TABLET, CHEWABLE 25 mg ORAL OTC monograph final 14 sections
Childrens DayClear Allergy Cough Chewables HUMAN OTC DRUG LABEL 2 58809-223 TABLET, CHEWABLE 12.50 mg ORAL OTC monograph final 14 sections
Texaclear Fast Acting Allergy Relief HUMAN OTC DRUG LABEL 2 58809-360 LIQUID 25 mg ORAL OTC monograph final 15 sections
Texaclear Fast Acting Allergy Relief HUMAN OTC DRUG LABEL 2 58809-360 LIQUID 25 mg ORAL OTC monograph final 15 sections
TexaClear Kids Allergy HUMAN OTC DRUG LABEL 2 58809-925 LIQUID 12.50 mg ORAL OTC monograph final 14 sections
VANACOF HUMAN OTC DRUG LABEL 3 58809-999 LIQUID 12.50 mg ORAL OTC monograph final 16 sections