acetohexamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antihyperglycaemics | 57 | 968-81-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.50 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 3.43 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 77.06 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 23, 1964 | FDA | LILLY |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A10BB31 | ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS Sulfonylureas |
| MeSH PA | D007004 | Hypoglycemic Agents |
| CHEBI has role | CHEBI:35526 | antidiabetic |
| CHEBI has role | CHEBI:90415 | insulin secretagogues |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Diabetes mellitus type 2 | indication | 44054006 | DOID:9352 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.63 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sulfonylurea receptor 1, Kir6.2 | Ion channel | BLOCKER | Ki | 4.64 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| 4017503 | VUID |
| N0000145888 | NUI |
| D00219 | KEGG_DRUG |
| 173 | RXNORM |
| C0000992 | UMLSCUI |
| CHEBI:28052 | CHEBI |
| CHEMBL1589 | ChEMBL_ID |
| DB00414 | DRUGBANK_ID |
| D000092 | MESH_DESCRIPTOR_UI |
| 1989 | PUBCHEM_CID |
| 6793 | IUPHAR_LIGAND_ID |
| 1134 | INN_ID |
| QGC8W08I6I | UNII |
| 387210001 | SNOMEDCT_US |
| 39064002 | SNOMEDCT_US |
| 4017503 | VANDF |
| 4123 | MMSL |
| 522 | MMSL |
| 873 | MMSL |
| d00162 | MMSL |
| 000907 | NDDF |
Pharmaceutical products:
None