ceruletide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| peptides and glycopeptides | 579 | 17650-98-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A specific decapeptide obtained from the skin of Hila caerulea, an Australian amphibian. Caerulein is similar in action and composition to CHOLECYSTOKININ. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA | PHARMACIA AND UPJOHN |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | V04CC04 | VARIOUS DIAGNOSTIC AGENTS OTHER DIAGNOSTIC AGENTS Tests for bile duct patency |
| CHEBI has role | CHEBI:33295 | diagnostic aid |
| CHEBI has role | CHEBI:55324 | gastrointestinal drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Diagnostic aid | indication | 2949005 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.49 | acidic |
| pKa2 | 4.09 | acidic |
| pKa3 | 12.02 | acidic |
| pKa4 | 12.56 | acidic |
| pKa5 | 12.62 | acidic |
| pKa6 | 13.04 | acidic |
| pKa7 | 13.18 | acidic |
| pKa8 | 13.27 | acidic |
| pKa9 | 13.31 | acidic |
| pKa10 | 13.66 | acidic |
| pKa11 | 13.8 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Cholecystokinin receptor type A | GPCR | AGONIST | DRUGBANK | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D03442 | KEGG_DRUG |
| 71247-25-1 | SECONDARY_CAS_RN |
| 20024 | RXNORM |
| C0006639 | UMLSCUI |
| CHEBI:59219 | CHEBI |
| CHEMBL1201355 | ChEMBL_ID |
| CHEMBL1200755 | ChEMBL_ID |
| D002108 | MESH_DESCRIPTOR_UI |
| DB00403 | DRUGBANK_ID |
| C032637 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7589 | IUPHAR_LIGAND_ID |
| 3351 | INN_ID |
| 888Y08971B | UNII |
| 16129675 | PUBCHEM_CID |
| 001218 | NDDF |
| 004709 | NDDF |
Pharmaceutical products:
None