ceruletide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
peptides and glycopeptides 579 17650-98-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ceruletide diethylamine
  • caerulein diethylamine salt
  • caerulein compd. with N-ethylethanamine
  • ceruletide
  • caerulein
A specific decapeptide obtained from the skin of Hila caerulea, an Australian amphibian. Caerulein is similar in action and composition to CHOLECYSTOKININ. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction.
  • Molecular weight: 1352.41
  • Formula: C58H73N13O21S2
  • CLOGP: -5.64
  • LIPINSKI: 3
  • HAC: 34
  • HDO: 17
  • TPSA: 551.40
  • ALOGS: -5.07
  • ROTB: 38

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC V04CC04 VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Tests for bile duct patency
CHEBI has role CHEBI:33295 diagnostic aid
CHEBI has role CHEBI:55324 gastrointestinal agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Diagnostic aid indication 2949005

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.49 acidic
pKa2 4.09 acidic
pKa3 12.02 acidic
pKa4 12.56 acidic
pKa5 12.62 acidic
pKa6 13.04 acidic
pKa7 13.18 acidic
pKa8 13.27 acidic
pKa9 13.31 acidic
pKa10 13.66 acidic
pKa11 13.8 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cholecystokinin receptor type A GPCR AGONIST DRUGBANK CHEMBL

External reference:

IDSource
D03442 KEGG_DRUG
71247-25-1 SECONDARY_CAS_RN
C0006639 UMLSCUI
CHEBI:59219 CHEBI
CHEMBL1201355 ChEMBL_ID
CHEMBL1200755 ChEMBL_ID
DB00403 DRUGBANK_ID
D002108 MESH_DESCRIPTOR_UI
C032637 MESH_SUPPLEMENTAL_RECORD_UI
16129675 PUBCHEM_CID
7589 IUPHAR_LIGAND_ID
3351 INN_ID
888Y08971B UNII
20024 RXNORM
001218 NDDF
004709 NDDF

Pharmaceutical products:

None