Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, cefalosporanic acid derivatives | 576 | 38821-53-3 |
Dose | Unit | Route |
---|---|---|
2 | g | O |
2 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 26 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 86 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 190.89 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 94 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.21 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 3.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.95 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 0.85 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 19, 1974 | FDA | APOTHECON |
None
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Foetal monitoring abnormal | 63.25 | 59.87 | 8 | 442 | 186 | 79743752 |
None
Source | Code | Description |
---|---|---|
ATC | J01DB09 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS First-generation cephalosporins |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Acute otitis media | indication | 3110003 | |
Prostatitis | indication | 9713002 | DOID:14654 |
Haemophilus Influenzae Acute Otitis Media | indication | 19021002 | |
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Staphylococcal pneumonia | indication | 22754005 | |
Pneumonia due to Streptococcus | indication | 34020007 | |
Streptococcal tonsillitis | indication | 41582007 | |
Lower respiratory tract infection | indication | 50417007 | |
Upper respiratory infection | indication | 54150009 | |
Klebsiella cystitis | indication | 60867007 | |
Urinary tract infectious disease | indication | 68566005 | |
Haemophilus influenzae pneumonia | indication | 70036007 | |
Tonsillitis | indication | 90176007 | DOID:10456 |
Infection of bone | indication | 111253001 | |
Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
Pneumonia | indication | 233604007 | DOID:552 |
Escherichia coli urinary tract infection | indication | 301011002 | |
Proteus urinary tract infection | indication | 301012009 | |
Streptococcus pyogenes infection | indication | 302809008 | |
Infective otitis media | indication | 312218008 | |
Infectious disorder of joint | indication | 363162000 | |
Pharyngitis | indication | 405737000 | DOID:2275 |
Infection due to Staphylococcus aureus | indication | 406602003 | |
Staphylococcus Acute Otitis Media | indication | 703469002 | |
Enterococcus Urinary Tract Infection | indication | ||
Klebsiella Prostatitis | indication | ||
Prevention of Perioperative Infection | indication | ||
Proteus Prostatitis | indication | ||
Enterococcus Prostatitis | indication | ||
Acute nephropathy | contraindication | 58574008 | |
Pseudomembranous enterocolitis | contraindication | 397683000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.77 | acidic |
pKa2 | 7.56 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Matrix metalloproteinase-9 | Enzyme | IC50 | 5.40 | WOMBAT-PK | |||||
Somatostatin receptor type 4 | GPCR | IC50 | 4.30 | WOMBAT-PK | |||||
Bacterial penicillin-binding protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
Penicillin-binding protein 1A | Enzyme | WOMBAT-PK |
ID | Source |
---|---|
4017745 | VUID |
N0000146111 | NUI |
D00264 | KEGG_DRUG |
2239 | RXNORM |
C0007738 | UMLSCUI |
CHEBI:3547 | CHEBI |
CHEMBL1604 | ChEMBL_ID |
DB01333 | DRUGBANK_ID |
4830 | IUPHAR_LIGAND_ID |
38103 | PUBCHEM_CID |
3082 | MMSL |
4397 | MMSL |
d00053 | MMSL |
002718 | NDDF |
16791000 | SNOMEDCT_US |
387091007 | SNOMEDCT_US |
D002515 | MESH_DESCRIPTOR_UI |
4017745 | VANDF |
F1BC02I72W | UNII |
None