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| Stem definition | Drug id | CAS RN |
|---|---|---|
| monoclonal antibodies (humanized origin); cardiovascular | 5760 | 1312299-39-0 |
| Molecule | Description |
|---|---|
|
Synonyms:
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Concizumab is a monoclonal antibody used for the treatment of hemophilia B. It is an anti-tissue factor pathway inhibitor.
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| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 25, 2023 | PMDA | Novo Nordisk Pharma |
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| Source | Code | Description |
|---|---|---|
| ATC | B02BX10 | BLOOD AND BLOOD FORMING ORGANS ANTIHEMORRHAGICS VITAMIN K AND OTHER HEMOSTATICS Other systemic hemostatics |
| FDA EPC | N0000194160 | Tissue Factor Pathway Inhibitor Antagonist |
| FDA MoA | N0000194161 | Tissue Factor Pathway Inhibitor Antagonists |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Prophylactic treatment of hemophilia A and B | indication | 90935002 |
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| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Tissue factor pathway inhibitor | Secreted | BINDING AGENT | Kd | 10.60 | SCIENTIFIC LITERATURE | DRUG LABEL |
| ID | Source |
|---|---|
| CHEMBL4297730 | ChEMBL_ID |
| C574488 | MESH_SUPPLEMENTAL_RECORD_UI |
| 11182 | IUPHAR_LIGAND_ID |
| DB12820 | DRUGBANK_ID |
| 4043679 | VANDF |
| C3494079 | UMLSCUI |
| CHEBI:757182 | CHEBI |
| 9636 | INN_ID |
| 41976 | MMSL |
| d10108 | MMSL |
| 68603V9EAF | UNII |
| 2708333 | RXNORM |
| 1674471000168103 | SNOMEDCT_US |
| D11847 | KEGG_DRUG |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Alhemo | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0169-2080 | INJECTION, SOLUTION | 100 mg | SUBCUTANEOUS | BLA | 28 sections |
| Alhemo | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0169-2081 | INJECTION, SOLUTION | 100 mg | SUBCUTANEOUS | BLA | 28 sections |
| Alhemo | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0169-2084 | INJECTION, SOLUTION | 40 mg | SUBCUTANEOUS | BLA | 28 sections |