lusutrombopag Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
5059 1110766-97-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lusutrombopag
  • S-888711
  • S 888711
  • mulpleta
a thrombopoietin receptor agonist
  • Molecular weight: 591.54
  • Formula: C29H32Cl2N2O5S
  • CLOGP: 7.92
  • LIPINSKI: 2
  • HAC: 7
  • HDO: 2
  • TPSA: 97.75
  • ALOGS: -6.61
  • ROTB: 13

  • Status: ONP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 31, 2018 FDA SHIONOGI INC
Feb. 18, 2019 EMA SHIONOGI B.V.
Sept. 28, 2015 PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC B02BX07 BLOOD AND BLOOD FORMING ORGANS
ANTIHEMORRHAGICS
VITAMIN K AND OTHER HEMOSTATICS
Other systemic hemostatics

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Thrombocytopenic disorder indication 302215000 DOID:1588

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.45 acidic
pKa2 7.41 acidic
pKa3 0.94 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
3MG MULPLETA SHIONOGI INC N210923 July 31, 2018 RX TABLET ORAL 7601746 Sept. 5, 2024 TREATMENT OF THROMBOCYTOPENIA IN ADULT PATIENTS WITH CHRONIC LIVER DISEASE WHO ARE SCHEDULED TO UNDERGO A PROCEDURE

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
3MG MULPLETA SHIONOGI INC N210923 July 31, 2018 RX TABLET ORAL July 31, 2023 NEW CHEMICAL ENTITY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Thrombopoietin receptor Membrane receptor AGONIST EC50 7.08 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
6LL5JFU42F UNII
D10476 KEGG_DRUG
4037779 VANDF
C4309207 UMLSCUI
CHEBI:136051 CHEBI
CHEMBL2107831 ChEMBL_ID
49843517 PUBCHEM_CID
DB13125 DRUGBANK_ID
C000611387 MESH_SUPPLEMENTAL_RECORD_UI
10032 IUPHAR_LIGAND_ID
9410 INN_ID
2054984 RXNORM
286900 MMSL
34734 MMSL
d08854 MMSL
017667 NDDF
773263005 SNOMEDCT_US
773265003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Mulpleta HUMAN PRESCRIPTION DRUG LABEL 1 59630-551 TABLET, FILM COATED 3 mg ORAL NDA 26 sections