foscarbidopa 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
dopamine receptor agonists, dopamine derivatives, used as antiparkinsonism/prolactin inhibitors 5725 1907685-81-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • foscarbidopa
  • foscarbidopa hydrate
  • ABBV-951
Foscarbidopa and foslevodopa combination (ABBV-951) was aproved by PMDA for the treatment of motor fluctuations in patients with advanced Parkinson’s disease. Foscarbidopa and foslevodopa are prodrugs of carbidopa and levodopa, respectively. They have higher solubility than their parent compounds, which allows them to be administered as a continuous subcutaneous infusion.
  • Molecular weight: 306.21
  • Formula: C10H15N2O7P
  • CLOGP:
  • LIPINSKI: 1
  • HAC: 9
  • HDO: 6
  • TPSA: 162.34
  • ALOGS:
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 23, 2022 PMDA AbbVie GK

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Parkinson's disease indication 49049000 DOID:14330




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
CHEBI:192512 CHEBI
CHEMBL4802240 ChEMBL_ID
DB16171 DRUGBANK_ID
C5238148 UMLSCUI
CHEMBL4594379 ChEMBL_ID
11007 INN_ID
121288738 PUBCHEM_CID
D12057 KEGG_DRUG
5NT8HCA4OO UNII

Pharmaceutical products:

None