Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, cefalosporanic acid derivatives | 571 | 15686-71-2 |
Dose | Unit | Route |
---|---|---|
2 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 13.50 mg/mL | Bocci G, Oprea TI, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 91 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 192.00 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 90 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.21 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 3.90 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.85 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 0.57 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 4, 1971 | FDA | SHIONOGI INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 1050.88 | 11.05 | 1127 | 38944 | 309560 | 63139391 |
Cross sensitivity reaction | 214.97 | 11.05 | 72 | 39999 | 2090 | 63446861 |
Type IV hypersensitivity reaction | 212.88 | 11.05 | 77 | 39994 | 2821 | 63446130 |
Loss of employment | 136.82 | 11.05 | 52 | 40019 | 2192 | 63446759 |
Cellulitis | 129.31 | 11.05 | 205 | 39866 | 81753 | 63367198 |
Synovitis | 100.60 | 11.05 | 4 | 40067 | 186914 | 63262037 |
Pemphigus | 95.39 | 11.05 | 5 | 40066 | 183721 | 63265230 |
Urinary tract discomfort | 94.47 | 11.05 | 29 | 40042 | 631 | 63448320 |
Oesophageal spasm | 91.55 | 11.05 | 43 | 40028 | 3080 | 63445871 |
Systemic lupus erythematosus | 88.92 | 11.05 | 13 | 40058 | 208905 | 63240046 |
Hand deformity | 87.22 | 11.05 | 3 | 40068 | 159454 | 63289497 |
Alveolar osteitis | 85.60 | 11.05 | 29 | 40042 | 872 | 63448079 |
Urinary tract infection | 82.38 | 11.05 | 358 | 39713 | 264326 | 63184625 |
Glossodynia | 81.27 | 11.05 | 9 | 40062 | 178867 | 63270084 |
Oesophageal pain | 78.83 | 11.05 | 41 | 40030 | 3660 | 63445291 |
Tunnel vision | 77.10 | 11.05 | 29 | 40042 | 1187 | 63447764 |
Animal scratch | 76.27 | 11.05 | 30 | 40041 | 1388 | 63447563 |
Infusion related reaction | 75.90 | 11.05 | 30 | 40041 | 245491 | 63203460 |
Arthropathy | 70.45 | 11.05 | 30 | 40041 | 234762 | 63214189 |
Pericarditis | 70.16 | 11.05 | 3 | 40068 | 131576 | 63317375 |
Drug ineffective | 69.84 | 11.05 | 382 | 39689 | 1044383 | 62404568 |
Bladder pain | 68.34 | 11.05 | 32 | 40039 | 2276 | 63446675 |
Joint swelling | 66.83 | 11.05 | 65 | 40006 | 327601 | 63121350 |
Lymphoedema | 62.88 | 11.05 | 55 | 40016 | 11637 | 63437314 |
Rash maculo-papular | 60.52 | 11.05 | 87 | 39984 | 31809 | 63417142 |
Bronchopulmonary aspergillosis allergic | 59.81 | 11.05 | 29 | 40042 | 2229 | 63446722 |
Sinus pain | 59.25 | 11.05 | 33 | 40038 | 3377 | 63445574 |
Wound complication | 56.36 | 11.05 | 33 | 40038 | 3714 | 63445237 |
Ear congestion | 54.32 | 11.05 | 29 | 40042 | 2730 | 63446221 |
Polymyalgia rheumatica | 50.81 | 11.05 | 31 | 40040 | 3760 | 63445191 |
Wound secretion | 50.04 | 11.05 | 33 | 40038 | 4581 | 63444370 |
Hepatic steatosis | 49.58 | 11.05 | 75 | 39996 | 28694 | 63420257 |
Paranasal sinus discomfort | 49.17 | 11.05 | 32 | 40039 | 4344 | 63444607 |
Limb injury | 47.62 | 11.05 | 69 | 40002 | 25408 | 63423543 |
Cystitis | 47.12 | 11.05 | 106 | 39965 | 54885 | 63394066 |
Alopecia | 46.55 | 11.05 | 89 | 39982 | 337447 | 63111504 |
Treatment failure | 46 | 11.05 | 35 | 40036 | 199008 | 63249943 |
Emotional distress | 44.01 | 11.05 | 76 | 39995 | 32473 | 63416478 |
Toxicity to various agents | 43.82 | 11.05 | 55 | 40016 | 247195 | 63201756 |
General physical health deterioration | 43.33 | 11.05 | 38 | 40033 | 201364 | 63247587 |
Rash | 42.47 | 11.05 | 540 | 39531 | 560331 | 62888620 |
Rheumatoid arthritis | 41.40 | 11.05 | 60 | 40011 | 253759 | 63195192 |
Gastric disorder | 40.12 | 11.05 | 79 | 39992 | 37290 | 63411661 |
Bronchitis | 39.55 | 11.05 | 170 | 39901 | 124765 | 63324186 |
Injury | 37.93 | 11.05 | 117 | 39954 | 73130 | 63375821 |
Swollen tongue | 37.88 | 11.05 | 74 | 39997 | 34726 | 63414225 |
Nasal polyps | 37.80 | 11.05 | 31 | 40040 | 6008 | 63442943 |
Urticaria | 36.28 | 11.05 | 203 | 39868 | 165599 | 63283352 |
Opsoclonus myoclonus | 36.24 | 11.05 | 10 | 40061 | 147 | 63448804 |
Cholecystitis chronic | 35.42 | 11.05 | 38 | 40033 | 10323 | 63438628 |
Depression | 34.99 | 11.05 | 228 | 39843 | 196264 | 63252687 |
Acute generalised exanthematous pustulosis | 34.98 | 11.05 | 39 | 40032 | 11060 | 63437891 |
Hepatitis infectious mononucleosis | 34.30 | 11.05 | 9 | 40062 | 108 | 63448843 |
Nephrolithiasis | 33.83 | 11.05 | 79 | 39992 | 41905 | 63407046 |
Dysuria | 32.28 | 11.05 | 68 | 40003 | 33670 | 63415281 |
Discomfort | 32.04 | 11.05 | 35 | 40036 | 167339 | 63281612 |
Hepatic enzyme increased | 31.84 | 11.05 | 49 | 40022 | 202279 | 63246672 |
Swelling face | 31.58 | 11.05 | 100 | 39971 | 63375 | 63385576 |
Chronic kidney disease | 30.83 | 11.05 | 80 | 39991 | 45318 | 63403633 |
Hallucination | 30.68 | 11.05 | 90 | 39981 | 54727 | 63394224 |
Skin laceration | 30.66 | 11.05 | 53 | 40018 | 22655 | 63426296 |
Bronchiectasis | 30.57 | 11.05 | 44 | 40027 | 16098 | 63432853 |
Hypoaesthesia oral | 29.93 | 11.05 | 39 | 40032 | 12994 | 63435957 |
Blood urine present | 29.90 | 11.05 | 42 | 40029 | 15027 | 63433924 |
Calculus urinary | 28.53 | 11.05 | 15 | 40056 | 1369 | 63447582 |
Uterine perforation | 28.25 | 11.05 | 28 | 40043 | 6935 | 63442016 |
Bronchomalacia | 28.21 | 11.05 | 9 | 40062 | 223 | 63448728 |
Sleep apnoea syndrome | 28.20 | 11.05 | 59 | 40012 | 29074 | 63419877 |
Anxiety | 28.17 | 11.05 | 234 | 39837 | 217307 | 63231644 |
Oedema | 27.99 | 11.05 | 129 | 39942 | 97493 | 63351458 |
Muscle injury | 27.93 | 11.05 | 4 | 40067 | 65341 | 63383610 |
Intentional product use issue | 27.65 | 11.05 | 24 | 40047 | 127868 | 63321083 |
Therapeutic product effect incomplete | 27.61 | 11.05 | 23 | 40048 | 125033 | 63323918 |
Diarrhoea | 27.53 | 11.05 | 617 | 39454 | 714749 | 62734202 |
Contraindicated product administered | 26.92 | 11.05 | 61 | 40010 | 217587 | 63231364 |
Pigment nephropathy | 26.42 | 11.05 | 6 | 40065 | 37 | 63448914 |
Hypokinesia | 26.41 | 11.05 | 38 | 40033 | 13898 | 63435053 |
Migraine | 26.33 | 11.05 | 132 | 39939 | 103214 | 63345737 |
Dysphonia | 25.53 | 11.05 | 77 | 39994 | 47537 | 63401414 |
Completed suicide | 25.17 | 11.05 | 33 | 40038 | 145640 | 63303311 |
Procedural pain | 24.87 | 11.05 | 47 | 40024 | 21522 | 63427429 |
Blood iron decreased | 24.83 | 11.05 | 38 | 40033 | 14683 | 63434268 |
Swelling | 24.66 | 11.05 | 90 | 39981 | 275288 | 63173663 |
Familial periodic paralysis | 22.95 | 11.05 | 6 | 40065 | 71 | 63448880 |
Gallbladder disorder | 22.90 | 11.05 | 42 | 40029 | 18800 | 63430151 |
Localised infection | 22.35 | 11.05 | 55 | 40016 | 30155 | 63418796 |
Abdominal pain upper | 22.07 | 11.05 | 213 | 39858 | 206231 | 63242720 |
Rales | 21.73 | 11.05 | 33 | 40038 | 12664 | 63436287 |
Anaphylactic reaction | 21.72 | 11.05 | 91 | 39980 | 66009 | 63382942 |
Deep vein thrombosis | 21.32 | 11.05 | 107 | 39964 | 83693 | 63365258 |
Hypoacusis | 21.18 | 11.05 | 47 | 40024 | 24104 | 63424847 |
Folliculitis | 21.04 | 11.05 | 9 | 40062 | 70308 | 63378643 |
Agitation neonatal | 20.85 | 11.05 | 9 | 40062 | 528 | 63448423 |
Pollakiuria | 20.81 | 11.05 | 51 | 40020 | 27886 | 63421065 |
Wound | 20.80 | 11.05 | 45 | 40026 | 163218 | 63285733 |
Cardiac failure congestive | 20.75 | 11.05 | 114 | 39957 | 92319 | 63356632 |
Myopathy | 20.46 | 11.05 | 30 | 40041 | 11161 | 63437790 |
Idiosyncratic drug reaction | 20.04 | 11.05 | 10 | 40061 | 818 | 63448133 |
Movement disorder | 19.96 | 11.05 | 43 | 40028 | 21618 | 63427333 |
Intentional overdose | 19.89 | 11.05 | 11 | 40060 | 74141 | 63374810 |
Burning sensation | 19.54 | 11.05 | 77 | 39994 | 54330 | 63394621 |
Haematuria | 19.40 | 11.05 | 51 | 40020 | 29106 | 63419845 |
Malaise | 19.29 | 11.05 | 369 | 39702 | 415585 | 63033366 |
Amniotic cavity infection | 18.67 | 11.05 | 11 | 40060 | 1252 | 63447699 |
Immunoglobulins decreased | 18.44 | 11.05 | 11 | 40060 | 1281 | 63447670 |
Irritable bowel syndrome | 18.38 | 11.05 | 15 | 40056 | 82397 | 63366554 |
Bullous haemorrhagic dermatosis | 18.28 | 11.05 | 5 | 40066 | 71 | 63448880 |
Type I hypersensitivity | 18.20 | 11.05 | 15 | 40056 | 2927 | 63446024 |
Ear pain | 18.05 | 11.05 | 57 | 40014 | 36061 | 63412890 |
Implant site haematoma | 17.91 | 11.05 | 5 | 40066 | 77 | 63448874 |
Loss of personal independence in daily activities | 17.89 | 11.05 | 21 | 40050 | 97269 | 63351682 |
Cough | 17.66 | 11.05 | 271 | 39800 | 292472 | 63156479 |
Tinnitus | 17.60 | 11.05 | 56 | 40015 | 35572 | 63413379 |
Mobility decreased | 17.51 | 11.05 | 31 | 40040 | 121128 | 63327823 |
Product dose omission issue | 17.38 | 11.05 | 225 | 39846 | 234088 | 63214863 |
Clostridium test positive | 17.09 | 11.05 | 15 | 40056 | 3186 | 63445765 |
Poor feeding infant | 17.04 | 11.05 | 7 | 40064 | 363 | 63448588 |
Staphylococcal infection | 16.98 | 11.05 | 61 | 40010 | 41195 | 63407756 |
Panic attack | 16.88 | 11.05 | 41 | 40030 | 22290 | 63426661 |
Gastrointestinal disorder | 16.86 | 11.05 | 36 | 40035 | 131203 | 63317748 |
Gastroenteritis bacterial | 16.86 | 11.05 | 7 | 40064 | 373 | 63448578 |
Musculoskeletal stiffness | 16.74 | 11.05 | 60 | 40011 | 184558 | 63264393 |
Anhedonia | 16.67 | 11.05 | 27 | 40044 | 10947 | 63438004 |
Coma | 16.62 | 11.05 | 10 | 40061 | 64354 | 63384597 |
Clostridium difficile infection | 16.62 | 11.05 | 49 | 40022 | 29873 | 63419078 |
Toxic epidermal necrolysis | 16.54 | 11.05 | 44 | 40027 | 25290 | 63423661 |
Drug dependence | 16.47 | 11.05 | 43 | 40028 | 24440 | 63424511 |
Drug ineffective for unapproved indication | 16.33 | 11.05 | 53 | 40018 | 34010 | 63414941 |
Chills | 16.32 | 11.05 | 125 | 39946 | 113253 | 63335698 |
Delirium | 15.88 | 11.05 | 6 | 40065 | 50535 | 63398416 |
Pruritus | 15.85 | 11.05 | 318 | 39753 | 361135 | 63087816 |
Fluid retention | 15.74 | 11.05 | 77 | 39994 | 59609 | 63389342 |
Nasopharyngitis | 15.72 | 11.05 | 95 | 39976 | 254162 | 63194789 |
Sinus disorder | 15.38 | 11.05 | 42 | 40029 | 24511 | 63424440 |
C-reactive protein abnormal | 15.30 | 11.05 | 5 | 40066 | 46091 | 63402860 |
Vanishing bile duct syndrome | 15.28 | 11.05 | 8 | 40063 | 724 | 63448227 |
Skin infection | 15.24 | 11.05 | 31 | 40040 | 14971 | 63433980 |
Drug abuse | 15.20 | 11.05 | 14 | 40057 | 72504 | 63376447 |
Type 2 diabetes mellitus | 15.04 | 11.05 | 11 | 40060 | 63857 | 63385094 |
Lactic acidosis | 14.91 | 11.05 | 3 | 40068 | 38284 | 63410667 |
C-reactive protein increased | 14.82 | 11.05 | 23 | 40048 | 94684 | 63354267 |
Complement factor C4 increased | 14.71 | 11.05 | 5 | 40066 | 152 | 63448799 |
Multiple lentigines syndrome | 14.67 | 11.05 | 5 | 40066 | 153 | 63448798 |
Foetal heart rate decreased | 14.64 | 11.05 | 5 | 40066 | 154 | 63448797 |
Influenza | 14.62 | 11.05 | 118 | 39953 | 108604 | 63340347 |
Abscess drainage | 14.51 | 11.05 | 7 | 40064 | 532 | 63448419 |
Overdose | 14.42 | 11.05 | 32 | 40039 | 115046 | 63333905 |
Purpura senile | 14.22 | 11.05 | 7 | 40064 | 556 | 63448395 |
Joint injury | 14.17 | 11.05 | 46 | 40025 | 29526 | 63419425 |
Feeling cold | 14.11 | 11.05 | 40 | 40031 | 23848 | 63425103 |
Off label use | 13.94 | 11.05 | 322 | 39749 | 674140 | 62774811 |
Pyelonephritis | 13.83 | 11.05 | 33 | 40038 | 17745 | 63431206 |
Clostridium difficile colitis | 13.71 | 11.05 | 36 | 40035 | 20533 | 63428418 |
Morbid thoughts | 13.55 | 11.05 | 7 | 40064 | 616 | 63448335 |
Umbilical cord around neck | 13.50 | 11.05 | 5 | 40066 | 196 | 63448755 |
Angioedema | 13.46 | 11.05 | 63 | 40008 | 47902 | 63401049 |
Fall | 13.36 | 11.05 | 333 | 39738 | 392001 | 63056950 |
Skin cancer | 13.19 | 11.05 | 25 | 40046 | 11470 | 63437481 |
Breast abscess | 13.01 | 11.05 | 10 | 40061 | 1766 | 63447185 |
Developmental hip dysplasia | 12.94 | 11.05 | 9 | 40062 | 1363 | 63447588 |
Liposuction | 12.88 | 11.05 | 3 | 40068 | 21 | 63448930 |
Implant site infection | 12.85 | 11.05 | 8 | 40063 | 1006 | 63447945 |
Condition aggravated | 12.74 | 11.05 | 178 | 39893 | 402039 | 63046912 |
Ill-defined disorder | 12.66 | 11.05 | 20 | 40051 | 81735 | 63367216 |
Hidradenitis | 12.59 | 11.05 | 12 | 40059 | 2834 | 63446117 |
Sleep disorder | 12.58 | 11.05 | 20 | 40051 | 81546 | 63367405 |
Rhabdomyolysis | 12.56 | 11.05 | 6 | 40065 | 43945 | 63405006 |
Ureteric obstruction | 12.55 | 11.05 | 10 | 40061 | 1860 | 63447091 |
Appetite disorder | 12.49 | 11.05 | 19 | 40052 | 7302 | 63441649 |
Retroperitoneal haematoma | 12.35 | 11.05 | 12 | 40059 | 2901 | 63446050 |
Therapy non-responder | 12.30 | 11.05 | 18 | 40053 | 75883 | 63373068 |
Scar | 12.29 | 11.05 | 27 | 40044 | 13755 | 63435196 |
Helicobacter duodenal ulcer | 12.22 | 11.05 | 3 | 40068 | 27 | 63448924 |
Maternal exposure during pregnancy | 12.19 | 11.05 | 85 | 39986 | 219977 | 63228974 |
Illness | 12.02 | 11.05 | 62 | 40009 | 48997 | 63399954 |
Lip swelling | 12.00 | 11.05 | 45 | 40026 | 31018 | 63417933 |
Malignant neoplasm progression | 11.87 | 11.05 | 21 | 40050 | 82100 | 63366851 |
Psoriatic arthropathy | 11.84 | 11.05 | 25 | 40046 | 91495 | 63357456 |
Ecthyma | 11.59 | 11.05 | 5 | 40066 | 293 | 63448658 |
Meconium in amniotic fluid | 11.57 | 11.05 | 5 | 40066 | 294 | 63448657 |
Incorrect dose administered | 11.53 | 11.05 | 71 | 40000 | 59897 | 63389054 |
Muscle haemorrhage | 11.47 | 11.05 | 12 | 40059 | 3167 | 63445784 |
Wrist fracture | 11.42 | 11.05 | 26 | 40045 | 13561 | 63435390 |
Vision blurred | 11.41 | 11.05 | 98 | 39973 | 91826 | 63357125 |
Arthritis infective | 11.32 | 11.05 | 17 | 40054 | 6461 | 63442490 |
Tarsal tunnel syndrome | 11.21 | 11.05 | 6 | 40065 | 568 | 63448383 |
Dysarthria | 11.19 | 11.05 | 55 | 40016 | 42656 | 63406295 |
Osteomyelitis | 11.16 | 11.05 | 39 | 40032 | 25981 | 63422970 |
Full blood count decreased | 11.16 | 11.05 | 39 | 40032 | 25985 | 63422966 |
Cholelithiasis | 11.11 | 11.05 | 56 | 40015 | 43869 | 63405082 |
Diabetic retinal oedema | 11.07 | 11.05 | 5 | 40066 | 327 | 63448624 |
Product odour abnormal | 11.06 | 11.05 | 8 | 40063 | 1288 | 63447663 |
Febrile neutropenia | 11.06 | 11.05 | 38 | 40033 | 118411 | 63330540 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 137.60 | 12.83 | 180 | 16429 | 80349 | 34859973 |
Cellulitis | 89.79 | 12.83 | 118 | 16491 | 52833 | 34887489 |
Rash | 74.87 | 12.83 | 254 | 16355 | 222498 | 34717824 |
Clostridium test positive | 59.78 | 12.83 | 30 | 16579 | 3312 | 34937010 |
Pruritus | 37.53 | 12.83 | 150 | 16459 | 141831 | 34798491 |
Clostridium difficile infection | 36.55 | 12.83 | 45 | 16564 | 18853 | 34921469 |
Drug abuse | 35.88 | 12.83 | 3 | 16606 | 99093 | 34841229 |
Drug interaction | 33.28 | 12.83 | 35 | 16574 | 225911 | 34714411 |
Pulmonary vasculitis | 33.19 | 12.83 | 12 | 16597 | 587 | 34939735 |
Venolymphatic malformation | 30.47 | 12.83 | 6 | 16603 | 23 | 34940299 |
Urticaria | 30.16 | 12.83 | 81 | 16528 | 62296 | 34878026 |
Autoimmune hepatitis | 29.72 | 12.83 | 21 | 16588 | 4339 | 34935983 |
Localised infection | 29.47 | 12.83 | 39 | 16570 | 17548 | 34922774 |
Urinary tract infection | 29.10 | 12.83 | 97 | 16512 | 83984 | 34856338 |
Skin infection | 28.55 | 12.83 | 26 | 16583 | 7711 | 34932611 |
Neuritis | 28.02 | 12.83 | 12 | 16597 | 922 | 34939400 |
Erythema | 27.74 | 12.83 | 99 | 16510 | 88681 | 34851641 |
Drug tolerance decreased | 27.58 | 12.83 | 15 | 16594 | 1952 | 34938370 |
Sleep disorder due to a general medical condition | 26.35 | 12.83 | 21 | 16588 | 5200 | 34935122 |
Skin laceration | 26.17 | 12.83 | 31 | 16578 | 12478 | 34927844 |
Circumoral oedema | 24.79 | 12.83 | 6 | 16603 | 69 | 34940253 |
Biliary sepsis | 24.41 | 12.83 | 10 | 16599 | 687 | 34939635 |
Rash pruritic | 24.41 | 12.83 | 45 | 16564 | 26896 | 34913426 |
Toxicity to various agents | 24.30 | 12.83 | 36 | 16573 | 200326 | 34739996 |
Cross sensitivity reaction | 23.41 | 12.83 | 12 | 16597 | 1385 | 34938937 |
Joint swelling | 23.35 | 12.83 | 72 | 16537 | 59818 | 34880504 |
Renal hypoplasia | 23.08 | 12.83 | 6 | 16603 | 94 | 34940228 |
Gut fermentation syndrome | 22.95 | 12.83 | 4 | 16605 | 6 | 34940316 |
Limb injury | 22.87 | 12.83 | 28 | 16581 | 11661 | 34928661 |
Clostridium difficile colitis | 22.03 | 12.83 | 32 | 16577 | 15698 | 34924624 |
Stevens-Johnson syndrome | 21.98 | 12.83 | 35 | 16574 | 18604 | 34921718 |
Respiratory symptom | 20.57 | 12.83 | 12 | 16597 | 1785 | 34938537 |
Type IV hypersensitivity reaction | 20.28 | 12.83 | 11 | 16598 | 1423 | 34938899 |
General physical health deterioration | 19.85 | 12.83 | 19 | 16590 | 128250 | 34812072 |
Kounis syndrome | 19.21 | 12.83 | 13 | 16596 | 2505 | 34937817 |
Skin lesion | 19.04 | 12.83 | 36 | 16573 | 21925 | 34918397 |
Rheumatoid factor negative | 18.86 | 12.83 | 9 | 16600 | 890 | 34939432 |
Haemorrhoids thrombosed | 18.79 | 12.83 | 6 | 16603 | 200 | 34940122 |
Middle ear effusion | 18.32 | 12.83 | 8 | 16601 | 644 | 34939678 |
Primary biliary cholangitis | 18.27 | 12.83 | 6 | 16603 | 219 | 34940103 |
Alveolar osteitis | 18.23 | 12.83 | 5 | 16604 | 97 | 34940225 |
Skin ulcer | 17.53 | 12.83 | 35 | 16574 | 22181 | 34918141 |
Renal injury | 17.49 | 12.83 | 24 | 16585 | 11171 | 34929151 |
Peripheral swelling | 17.18 | 12.83 | 77 | 16532 | 76464 | 34863858 |
Urinary tract discomfort | 17.11 | 12.83 | 5 | 16604 | 123 | 34940199 |
Lip haemorrhage | 17.05 | 12.83 | 8 | 16601 | 762 | 34939560 |
Retinal degeneration | 16.71 | 12.83 | 7 | 16602 | 509 | 34939813 |
Paradoxical pain | 16.66 | 12.83 | 3 | 16606 | 6 | 34940316 |
Swollen tongue | 16.64 | 12.83 | 27 | 16582 | 14578 | 34925744 |
Drug-induced liver injury | 16.58 | 12.83 | 40 | 16569 | 28792 | 34911530 |
Skin necrosis | 16.56 | 12.83 | 17 | 16592 | 5836 | 34934486 |
Tubulointerstitial nephritis | 16.44 | 12.83 | 33 | 16576 | 20991 | 34919331 |
Fungal skin infection | 16.38 | 12.83 | 12 | 16597 | 2622 | 34937700 |
Mucormycosis | 16.35 | 12.83 | 17 | 16592 | 5925 | 34934397 |
Polyomavirus-associated nephropathy | 16.35 | 12.83 | 14 | 16595 | 3830 | 34936492 |
Treatment failure | 16.25 | 12.83 | 54 | 16555 | 46643 | 34893679 |
Arthropathy | 16.20 | 12.83 | 38 | 16571 | 26869 | 34913453 |
Hypersensitivity vasculitis | 15.95 | 12.83 | 13 | 16596 | 3322 | 34937000 |
Perineal abscess | 15.50 | 12.83 | 6 | 16603 | 355 | 34939967 |
Factor V inhibition | 14.99 | 12.83 | 5 | 16604 | 192 | 34940130 |
Neovascular age-related macular degeneration | 14.74 | 12.83 | 5 | 16604 | 202 | 34940120 |
Skin cancer | 14.49 | 12.83 | 21 | 16588 | 10276 | 34930046 |
Urethral injury | 14.33 | 12.83 | 4 | 16605 | 83 | 34940239 |
Animal scratch | 14.21 | 12.83 | 5 | 16604 | 226 | 34940096 |
Renal tubular necrosis | 13.96 | 12.83 | 26 | 16583 | 15654 | 34924668 |
Swelling | 13.87 | 12.83 | 48 | 16561 | 42318 | 34898004 |
Therapy interrupted | 13.84 | 12.83 | 24 | 16585 | 13673 | 34926649 |
Allergy test positive | 13.82 | 12.83 | 4 | 16605 | 95 | 34940227 |
Reversible airways obstruction | 13.74 | 12.83 | 6 | 16603 | 483 | 34939839 |
Angioedema | 13.70 | 12.83 | 44 | 16565 | 37330 | 34902992 |
Herpes simplex | 13.70 | 12.83 | 15 | 16594 | 5544 | 34934778 |
Neurological symptom | 13.40 | 12.83 | 13 | 16596 | 4172 | 34936150 |
Acute hepatic failure | 13.37 | 12.83 | 24 | 16585 | 14050 | 34926272 |
Pyogenic granuloma | 13.28 | 12.83 | 5 | 16604 | 274 | 34940048 |
Mean platelet volume increased | 13.28 | 12.83 | 6 | 16603 | 524 | 34939798 |
Multiple allergies | 12.90 | 12.83 | 11 | 16598 | 2992 | 34937330 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 784.76 | 10.70 | 915 | 45442 | 298001 | 79400030 |
Type IV hypersensitivity reaction | 232.44 | 10.70 | 88 | 46269 | 3993 | 79694038 |
Cross sensitivity reaction | 225.81 | 10.70 | 84 | 46273 | 3628 | 79694403 |
Cellulitis | 170.74 | 10.70 | 260 | 46097 | 108800 | 79589231 |
Loss of employment | 130.24 | 10.70 | 51 | 46306 | 2536 | 79695495 |
Rash | 107.26 | 10.70 | 637 | 45720 | 577721 | 79120310 |
Oesophageal spasm | 96.93 | 10.70 | 45 | 46312 | 3411 | 79694620 |
Oesophageal pain | 90.71 | 10.70 | 46 | 46311 | 4233 | 79693798 |
Urinary tract discomfort | 85.17 | 10.70 | 27 | 46330 | 714 | 79697317 |
Urinary tract infection | 83.29 | 10.70 | 348 | 46009 | 274164 | 79423867 |
Alveolar osteitis | 81.68 | 10.70 | 27 | 46330 | 818 | 79697213 |
Animal scratch | 70.49 | 10.70 | 28 | 46329 | 1446 | 79696585 |
Synovitis | 68.38 | 10.70 | 5 | 46352 | 150729 | 79547302 |
Clostridium test positive | 68.10 | 10.70 | 44 | 46313 | 6410 | 79691621 |
Toxicity to various agents | 67.19 | 10.70 | 88 | 46269 | 421452 | 79276579 |
Tunnel vision | 65.24 | 10.70 | 27 | 46330 | 1551 | 79696480 |
Bladder pain | 64.21 | 10.70 | 30 | 46327 | 2307 | 79695724 |
Lymphoedema | 63.95 | 10.70 | 55 | 46302 | 12358 | 79685673 |
Urticaria | 62.68 | 10.70 | 243 | 46114 | 184958 | 79513073 |
Rash maculo-papular | 60.14 | 10.70 | 113 | 46244 | 55965 | 79642066 |
Drug abuse | 57.88 | 10.70 | 12 | 46345 | 162679 | 79535352 |
Swollen tongue | 57.59 | 10.70 | 95 | 46262 | 42475 | 79655556 |
Limb injury | 57.28 | 10.70 | 78 | 46279 | 29450 | 79668581 |
Sinus pain | 53.55 | 10.70 | 31 | 46326 | 3711 | 79694320 |
Infusion related reaction | 52.00 | 10.70 | 35 | 46322 | 230202 | 79467829 |
General physical health deterioration | 50.82 | 10.70 | 51 | 46306 | 275187 | 79422844 |
Ear congestion | 49.41 | 10.70 | 27 | 46330 | 2892 | 79695139 |
Pericarditis | 48.61 | 10.70 | 3 | 46354 | 104233 | 79593798 |
Clostridium difficile infection | 48.26 | 10.70 | 88 | 46269 | 42597 | 79655434 |
Bronchopulmonary aspergillosis allergic | 48.21 | 10.70 | 27 | 46330 | 3034 | 79694997 |
Cystitis | 46.60 | 10.70 | 98 | 46259 | 52634 | 79645397 |
Bronchitis | 46.30 | 10.70 | 174 | 46183 | 130470 | 79567561 |
Paranasal sinus discomfort | 46.08 | 10.70 | 30 | 46327 | 4426 | 79693605 |
Wound secretion | 45.98 | 10.70 | 34 | 46323 | 6154 | 79691877 |
Hand deformity | 45.59 | 10.70 | 4 | 46353 | 103915 | 79594116 |
Wound complication | 45.33 | 10.70 | 31 | 46326 | 4962 | 79693069 |
Skin laceration | 45.20 | 10.70 | 69 | 46288 | 28893 | 79669138 |
Pruritus | 45.04 | 10.70 | 387 | 45970 | 394261 | 79303770 |
Polymyalgia rheumatica | 43.17 | 10.70 | 29 | 46328 | 4508 | 79693523 |
Systemic lupus erythematosus | 39.04 | 10.70 | 11 | 46346 | 121138 | 79576893 |
Pemphigus | 38.32 | 10.70 | 6 | 46351 | 99576 | 79598455 |
Oedema | 38.09 | 10.70 | 154 | 46203 | 119426 | 79578605 |
Swelling face | 37.97 | 10.70 | 109 | 46248 | 71103 | 79626928 |
Acute generalised exanthematous pustulosis | 37.20 | 10.70 | 48 | 46309 | 17206 | 79680825 |
Emotional distress | 36.15 | 10.70 | 75 | 46282 | 39894 | 79658137 |
Cholecystitis chronic | 35.75 | 10.70 | 36 | 46321 | 9870 | 79688161 |
Nasal polyps | 34.80 | 10.70 | 31 | 46326 | 7296 | 79690735 |
Gastric disorder | 34.75 | 10.70 | 71 | 46286 | 37362 | 79660669 |
Injury | 34.19 | 10.70 | 111 | 46246 | 77385 | 79620646 |
Sleep apnoea syndrome | 33.64 | 10.70 | 69 | 46288 | 36409 | 79661622 |
Opsoclonus myoclonus | 33.20 | 10.70 | 10 | 46347 | 222 | 79697809 |
Migraine | 33.06 | 10.70 | 119 | 46238 | 87374 | 79610657 |
Uterine perforation | 32.61 | 10.70 | 28 | 46329 | 6275 | 79691756 |
Hepatitis infectious mononucleosis | 32.36 | 10.70 | 9 | 46348 | 149 | 79697882 |
Skin infection | 30.65 | 10.70 | 45 | 46312 | 18200 | 79679831 |
Localised infection | 29.96 | 10.70 | 67 | 46290 | 37508 | 79660523 |
Drug interaction | 29.22 | 10.70 | 133 | 46224 | 415050 | 79282981 |
Glossodynia | 28.77 | 10.70 | 12 | 46345 | 103325 | 79594706 |
Hepatic steatosis | 28.65 | 10.70 | 66 | 46291 | 37672 | 79660359 |
Completed suicide | 28.35 | 10.70 | 63 | 46294 | 245704 | 79452327 |
Drug ineffective | 28.13 | 10.70 | 451 | 45906 | 1080462 | 78617569 |
Pulmonary vasculitis | 28.05 | 10.70 | 12 | 46345 | 749 | 79697282 |
Nephrolithiasis | 27.86 | 10.70 | 81 | 46276 | 53210 | 79644821 |
Depression | 27.58 | 10.70 | 218 | 46139 | 216572 | 79481459 |
Anxiety | 26.90 | 10.70 | 241 | 46116 | 248271 | 79449760 |
Anaphylactic reaction | 26.78 | 10.70 | 108 | 46249 | 83635 | 79614396 |
Angioedema | 26.70 | 10.70 | 101 | 46256 | 75934 | 79622097 |
Intentional product use issue | 26.03 | 10.70 | 30 | 46327 | 152082 | 79545949 |
Pigment nephropathy | 25.66 | 10.70 | 6 | 46351 | 47 | 79697984 |
Hypoaesthesia oral | 25.43 | 10.70 | 36 | 46321 | 14088 | 79683943 |
Lactic acidosis | 25.41 | 10.70 | 5 | 46352 | 70354 | 79627677 |
Diarrhoea | 25.32 | 10.70 | 680 | 45677 | 879809 | 78818222 |
Chronic kidney disease | 25.01 | 10.70 | 90 | 46267 | 66064 | 79631967 |
Hepatic function abnormal | 24.77 | 10.70 | 6 | 46351 | 73101 | 79624930 |
Calculus urinary | 24.07 | 10.70 | 16 | 46341 | 2444 | 79695587 |
Clostridium difficile colitis | 24.01 | 10.70 | 56 | 46301 | 32227 | 79665804 |
Thrombocytopenia | 23.79 | 10.70 | 77 | 46280 | 265182 | 79432849 |
Gallbladder disorder | 23.30 | 10.70 | 41 | 46316 | 19299 | 79678732 |
Alopecia | 22.28 | 10.70 | 65 | 46292 | 231290 | 79466741 |
Coma | 21.78 | 10.70 | 16 | 46341 | 100633 | 79597398 |
Pollakiuria | 21.74 | 10.70 | 59 | 46298 | 37258 | 79660773 |
Blood urine present | 21.70 | 10.70 | 42 | 46315 | 21255 | 79676776 |
Procedural pain | 21.68 | 10.70 | 44 | 46313 | 23040 | 79674991 |
Type I hypersensitivity | 21.67 | 10.70 | 19 | 46338 | 4379 | 79693652 |
Deep vein thrombosis | 21.51 | 10.70 | 132 | 46225 | 120787 | 79577244 |
Erythema | 21.39 | 10.70 | 211 | 46146 | 223079 | 79474952 |
Gut fermentation syndrome | 21.09 | 10.70 | 4 | 46353 | 9 | 79698022 |
Febrile neutropenia | 20.75 | 10.70 | 67 | 46290 | 230932 | 79467099 |
Neutropenia | 20.32 | 10.70 | 92 | 46265 | 287618 | 79410413 |
Rhabdomyolysis | 20.31 | 10.70 | 18 | 46339 | 103113 | 79594918 |
Blood iron decreased | 20.28 | 10.70 | 34 | 46323 | 15400 | 79682631 |
Ear pain | 20.19 | 10.70 | 53 | 46304 | 32816 | 79665215 |
Stevens-Johnson syndrome | 19.96 | 10.70 | 59 | 46298 | 39107 | 79658924 |
Off label use | 19.59 | 10.70 | 391 | 45966 | 906824 | 78791207 |
Anaemia | 19.59 | 10.70 | 165 | 46192 | 444850 | 79253181 |
Dysphonia | 19.52 | 10.70 | 75 | 46282 | 56797 | 79641234 |
Intentional overdose | 19.12 | 10.70 | 20 | 46337 | 105940 | 79592091 |
Tinnitus | 19.10 | 10.70 | 63 | 46294 | 44270 | 79653761 |
Implant site haematoma | 18.70 | 10.70 | 6 | 46351 | 165 | 79697866 |
Hypokinesia | 18.70 | 10.70 | 37 | 46320 | 19023 | 79679008 |
Neuritis | 18.58 | 10.70 | 12 | 46345 | 1746 | 79696285 |
Familial periodic paralysis | 18.57 | 10.70 | 6 | 46351 | 169 | 79697862 |
Autoimmune hepatitis | 18.28 | 10.70 | 28 | 46329 | 11755 | 79686276 |
Skin cancer | 18.27 | 10.70 | 32 | 46325 | 15008 | 79683023 |
Burning sensation | 18.25 | 10.70 | 75 | 46282 | 58557 | 79639474 |
Dysuria | 18.15 | 10.70 | 68 | 46289 | 50883 | 79647148 |
Genital ulceration | 18.14 | 10.70 | 10 | 46347 | 1090 | 79696941 |
Panic attack | 18.00 | 10.70 | 42 | 46315 | 24174 | 79673857 |
Bronchiectasis | 17.94 | 10.70 | 40 | 46317 | 22346 | 79675685 |
Pemphigoid | 17.85 | 10.70 | 32 | 46325 | 15283 | 79682748 |
Sinus disorder | 17.84 | 10.70 | 40 | 46317 | 22424 | 79675607 |
Middle ear effusion | 17.34 | 10.70 | 13 | 46344 | 2402 | 79695629 |
Bullous haemorrhagic dermatosis | 17.33 | 10.70 | 5 | 46352 | 95 | 79697936 |
Surgery | 17.31 | 10.70 | 50 | 46307 | 32716 | 79665315 |
Hypoacusis | 16.90 | 10.70 | 47 | 46310 | 30103 | 79667928 |
Drug reaction with eosinophilia and systemic symptoms | 16.81 | 10.70 | 78 | 46279 | 64166 | 79633865 |
Lip swelling | 16.62 | 10.70 | 57 | 46300 | 40854 | 79657177 |
Therapeutic product effect incomplete | 16.58 | 10.70 | 36 | 46321 | 141609 | 79556422 |
Haemorrhoids thrombosed | 16.40 | 10.70 | 6 | 46351 | 247 | 79697784 |
Drug-induced liver injury | 16.37 | 10.70 | 79 | 46278 | 66038 | 79631993 |
Gastroenteritis bacterial | 16.29 | 10.70 | 7 | 46350 | 442 | 79697589 |
Product odour abnormal | 16.28 | 10.70 | 10 | 46347 | 1334 | 79696697 |
Product dose omission issue | 16.10 | 10.70 | 217 | 46140 | 247320 | 79450711 |
Skin ulcer | 15.87 | 10.70 | 68 | 46289 | 54082 | 79643949 |
Abdominal pain upper | 15.30 | 10.70 | 198 | 46159 | 223621 | 79474410 |
Tarsal tunnel syndrome | 15.10 | 10.70 | 7 | 46350 | 529 | 79697502 |
Cardiogenic shock | 15.09 | 10.70 | 3 | 46354 | 41911 | 79656120 |
Circumoral oedema | 15.01 | 10.70 | 6 | 46351 | 315 | 79697716 |
Therapy cessation | 14.97 | 10.70 | 52 | 46305 | 37510 | 79660521 |
Fungal skin infection | 14.94 | 10.70 | 18 | 46339 | 6018 | 79692013 |
Complement factor C4 increased | 14.92 | 10.70 | 5 | 46352 | 158 | 79697873 |
Hallucination | 14.87 | 10.70 | 93 | 46264 | 85652 | 79612379 |
Movement disorder | 14.79 | 10.70 | 42 | 46315 | 27217 | 79670814 |
Arthropathy | 14.79 | 10.70 | 53 | 46304 | 177058 | 79520973 |
Biliary sepsis | 14.59 | 10.70 | 10 | 46347 | 1607 | 79696424 |
Rash pruritic | 14.55 | 10.70 | 81 | 46276 | 71548 | 79626483 |
Paradoxical pain | 14.53 | 10.70 | 3 | 46354 | 12 | 79698019 |
Tubulointerstitial nephritis | 14.43 | 10.70 | 52 | 46305 | 38183 | 79659848 |
Oral pain | 14.43 | 10.70 | 46 | 46311 | 31752 | 79666279 |
Diabetic retinal oedema | 14.36 | 10.70 | 6 | 46351 | 353 | 79697678 |
Appetite disorder | 14.34 | 10.70 | 20 | 46337 | 7719 | 79690312 |
Haematuria | 14.09 | 10.70 | 78 | 46279 | 68758 | 79629273 |
Multiple lentigines syndrome | 13.92 | 10.70 | 5 | 46352 | 195 | 79697836 |
Toxic epidermal necrolysis | 13.85 | 10.70 | 57 | 46300 | 44524 | 79653507 |
Abscess drainage | 13.77 | 10.70 | 7 | 46350 | 647 | 79697384 |
Multiple organ dysfunction syndrome | 13.71 | 10.70 | 31 | 46326 | 120215 | 79577816 |
Idiosyncratic drug reaction | 13.70 | 10.70 | 9 | 46348 | 1348 | 79696683 |
Actinic keratosis | 13.32 | 10.70 | 17 | 46340 | 6025 | 79692006 |
Arthritis infective | 13.32 | 10.70 | 20 | 46337 | 8251 | 79689780 |
Chills | 13.25 | 10.70 | 147 | 46210 | 160087 | 79537944 |
Malignant neoplasm progression | 13.24 | 10.70 | 38 | 46319 | 135952 | 79562079 |
Hepatic enzyme increased | 13.12 | 10.70 | 58 | 46299 | 182552 | 79515479 |
Discomfort | 13.05 | 10.70 | 34 | 46323 | 125583 | 79572448 |
Fluid retention | 12.91 | 10.70 | 77 | 46280 | 69732 | 79628299 |
C-reactive protein abnormal | 12.85 | 10.70 | 6 | 46351 | 48361 | 79649670 |
Hidradenitis | 12.74 | 10.70 | 12 | 46345 | 3032 | 79694999 |
Kounis syndrome | 12.67 | 10.70 | 14 | 46343 | 4268 | 79693763 |
Blood creatine phosphokinase increased | 12.46 | 10.70 | 12 | 46345 | 66078 | 79631953 |
Morbid thoughts | 12.43 | 10.70 | 7 | 46350 | 795 | 79697236 |
Rheumatoid factor negative | 12.38 | 10.70 | 8 | 46349 | 1165 | 79696866 |
Helicobacter duodenal ulcer | 12.27 | 10.70 | 3 | 46354 | 29 | 79698002 |
Lip haemorrhage | 12.25 | 10.70 | 8 | 46349 | 1186 | 79696845 |
Tinea infection | 12.18 | 10.70 | 8 | 46349 | 1197 | 79696834 |
Joint injury | 12.16 | 10.70 | 43 | 46314 | 31292 | 79666739 |
Purpura senile | 12.12 | 10.70 | 6 | 46351 | 524 | 79697507 |
Skin induration | 12.04 | 10.70 | 14 | 46343 | 4511 | 79693520 |
Vulvovaginal mycotic infection | 11.94 | 10.70 | 14 | 46343 | 4552 | 79693479 |
Ureteric obstruction | 11.93 | 10.70 | 11 | 46346 | 2705 | 79695326 |
Staphylococcal infection | 11.89 | 10.70 | 66 | 46291 | 58229 | 79639802 |
Drug ineffective for unapproved indication | 11.82 | 10.70 | 60 | 46297 | 51178 | 79646853 |
Sleep disorder | 11.57 | 10.70 | 20 | 46337 | 85657 | 79612374 |
Wrist fracture | 11.53 | 10.70 | 23 | 46334 | 11898 | 79686133 |
Vanishing bile duct syndrome | 11.51 | 10.70 | 9 | 46348 | 1769 | 79696262 |
Agranulocytosis | 11.34 | 10.70 | 6 | 46351 | 45024 | 79653007 |
Hepatotoxicity | 11.32 | 10.70 | 8 | 46349 | 51344 | 79646687 |
Interstitial lung disease | 11.30 | 10.70 | 31 | 46326 | 112569 | 79585462 |
Gastrointestinal disorder | 11.28 | 10.70 | 35 | 46322 | 122170 | 79575861 |
Bone marrow failure | 11.22 | 10.70 | 8 | 46349 | 51099 | 79646932 |
Renal tubular necrosis | 11.16 | 10.70 | 36 | 46321 | 25003 | 79673028 |
Renal injury | 11.13 | 10.70 | 28 | 46329 | 16899 | 79681132 |
Back pain | 11.12 | 10.70 | 243 | 46114 | 303937 | 79394094 |
Polyomavirus-associated nephropathy | 11.12 | 10.70 | 15 | 46342 | 5612 | 79692419 |
Pancytopenia | 11.10 | 10.70 | 54 | 46303 | 165691 | 79532340 |
Illness | 11.10 | 10.70 | 55 | 46302 | 46456 | 79651575 |
Drug dependence | 11.04 | 10.70 | 50 | 46307 | 40719 | 79657312 |
Factor V inhibition | 10.81 | 10.70 | 5 | 46352 | 376 | 79697655 |
Breast abscess | 10.77 | 10.70 | 8 | 46349 | 1458 | 79696573 |
None
Source | Code | Description |
---|---|---|
ATC | J01DB01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS First-generation cephalosporins |
FDA CS | M0003827 | Cephalosporins |
FDA EPC | N0000175488 | Cephalosporin Antibacterial |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Acute otitis media | indication | 3110003 | |
Prostatitis | indication | 9713002 | DOID:14654 |
Haemophilus Influenzae Acute Otitis Media | indication | 19021002 | |
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Pneumonia due to Streptococcus | indication | 34020007 | |
Streptococcal tonsillitis | indication | 41582007 | |
Klebsiella cystitis | indication | 60867007 | |
Infection of bone | indication | 111253001 | |
Escherichia coli urinary tract infection | indication | 301011002 | |
Proteus urinary tract infection | indication | 301012009 | |
Streptococcus pyogenes infection | indication | 302809008 | |
Bacterial urinary infection | indication | 312124009 | |
Infective otitis media | indication | 312218008 | |
Infectious disorder of joint | indication | 363162000 | |
Infection due to Staphylococcus aureus | indication | 406602003 | |
Osteomyelitis due to Staphylococcus aureus | indication | 428783003 | |
Staphylococcus Acute Otitis Media | indication | 703469002 | |
Moraxella Catarrhalis Acute Otitis Media | indication | 703469002 | |
Klebsiella Prostatitis | indication | ||
Proteus Prostatitis | indication | ||
Streptococcus Osteomyelitis | indication | ||
Bacterial Mastitis | off-label use | ||
Prevention of Bacterial Endocarditis | off-label use | ||
Diabetic Foot Infection Due to Gram-Positive Bacteria | off-label use | ||
Colitis | contraindication | 64226004 | DOID:0060180 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Pseudomembranous enterocolitis | contraindication | 397683000 |
Species | Use | Relation |
---|---|---|
Dogs | Secondary superficial bacterial pyoderma caused by Staphylococcus pseudintermedius | Indication |
Product | Applicant | Ingredients |
---|---|---|
Rilexine Chewable Tablets | Virbac AH Inc. | 1 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.77 | acidic |
pKa2 | 13.53 | acidic |
pKa3 | 7.67 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Solute carrier family 15 member 2 | Transporter | IC50 | 4.38 | WOMBAT-PK | |||||
Bacterial penicillin-binding protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
Penicillin-binding protein 3 | Enzyme | WOMBAT-PK |
ID | Source |
---|---|
4018893 | VUID |
N0000179741 | NUI |
D00263 | KEGG_DRUG |
23325-78-2 | SECONDARY_CAS_RN |
1299782 | RXNORM |
C0007716 | UMLSCUI |
CHEBI:3534 | CHEBI |
CHEMBL1727 | ChEMBL_ID |
CHEMBL1200544 | ChEMBL_ID |
CHEMBL1200366 | ChEMBL_ID |
DB00567 | DRUGBANK_ID |
4832 | IUPHAR_LIGAND_ID |
105879-42-3 | SECONDARY_CAS_RN |
27447 | PUBCHEM_CID |
4393 | MMSL |
d00096 | MMSL |
002716 | NDDF |
002717 | NDDF |
387304003 | SNOMEDCT_US |
54062005 | SNOMEDCT_US |
54887004 | SNOMEDCT_US |
785690001 | SNOMEDCT_US |
D002506 | MESH_DESCRIPTOR_UI |
4018891 | VANDF |
4018893 | VANDF |
2400 | INN_ID |
OBN7UDS42Y | UNII |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2238 | TABLET | 250 mg | ORAL | ANDA | 19 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2238 | TABLET | 250 mg | ORAL | ANDA | 19 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2240 | TABLET | 500 mg | ORAL | ANDA | 19 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2240 | TABLET | 500 mg | ORAL | ANDA | 19 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3145 | CAPSULE | 250 mg | ORAL | ANDA | 23 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3145 | CAPSULE | 250 mg | ORAL | ANDA | 23 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3147 | CAPSULE | 500 mg | ORAL | ANDA | 23 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3147 | CAPSULE | 500 mg | ORAL | ANDA | 23 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4175 | POWDER, FOR SUSPENSION | 125 mg | ORAL | ANDA | 23 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4175 | POWDER, FOR SUSPENSION | 125 mg | ORAL | ANDA | 23 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4177 | POWDER, FOR SUSPENSION | 250 mg | ORAL | ANDA | 23 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4177 | POWDER, FOR SUSPENSION | 250 mg | ORAL | ANDA | 23 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9769 | SUSPENSION | 125 mg | ORAL | ANDA | 24 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9770 | SUSPENSION | 250 mg | ORAL | ANDA | 24 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9897 | CAPSULE | 500 mg | ORAL | ANDA | 23 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9898 | CAPSULE | 250 mg | ORAL | ANDA | 23 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-1243 | CAPSULE | 250 mg | ORAL | ANDA | 19 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-7244 | CAPSULE | 500 mg | ORAL | ANDA | 23 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-004 | CAPSULE | 500 mg | ORAL | ANDA | 23 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-013 | CAPSULE | 500 mg | ORAL | ANDA | 24 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-020 | CAPSULE | 500 mg | ORAL | ANDA | 23 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-021 | CAPSULE | 250 mg | ORAL | ANDA | 24 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-025 | CAPSULE | 500 mg | ORAL | ANDA | 24 sections |
cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-057 | CAPSULE | 500 mg | ORAL | ANDA | 24 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-066 | CAPSULE | 250 mg | ORAL | ANDA | 19 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-082 | CAPSULE | 500 mg | ORAL | ANDA | 21 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-142 | CAPSULE | 250 mg | ORAL | ANDA | 23 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-503 | CAPSULE | 500 mg | ORAL | ANDA | 13 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-529 | CAPSULE | 500 mg | ORAL | ANDA | 22 sections |
Cephalexin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-617 | CAPSULE | 500 mg | ORAL | ANDA | 19 sections |