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| Stem definition | Drug id | CAS RN |
|---|---|---|
| enzymes | 5703 | 927883-84-9 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
Olipudase alfa is a recombinant human acid sphingomyelinase that reduces sphingomyelin (SM) accumulation in organs of patients with Acid Sphingomyelinase Deficiency (ASMD).
|
| Dose | Unit | Route |
|---|---|---|
| 15 | mg | P |
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| Date | Agency | Company | Orphan |
|---|---|---|---|
| June 24, 2022 | EMA | GENZYME EUROPE BV | |
| Aug. 31, 2022 | FDA | GENZYME CORP | |
| March 28, 2022 | PMDA | Sanofi K.K. |
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| Source | Code | Description |
|---|---|---|
| ATC | A16AB25 | ALIMENTARY TRACT AND METABOLISM OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS Enzymes |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Niemann-Pick disease, type B | indication | 39390005 | |
| Niemann-Pick disease, type A | indication | 52165006 |
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| ID | Source |
|---|---|
| CHEBI:755825 | CHEBI |
| CHEMBL3707358 | ChEMBL_ID |
| C000608782 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB12835 | DRUGBANK_ID |
| 2054161000122108 | SNOMEDCT_US |
| 4041694 | VANDF |
| 4041695 | VANDF |
| C4278198 | UMLSCUI |
| 9966 | INN_ID |
| D10820 | KEGG_DRUG |
| 361411 | MMSL |
| 40866 | MMSL |
| d09916 | MMSL |
| 019170 | NDDF |
| 6D5766Q4OP | UNII |
| 2610406 | RXNORM |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| XENPOZYME | HUMAN PRESCRIPTION DRUG LABEL | 1 | 58468-0050 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 20 mg | INTRAVENOUS | BLA | 31 sections |
| XENPOZYME | HUMAN PRESCRIPTION DRUG LABEL | 1 | 58468-0051 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 4 mg | INTRAVENOUS | BLA | 31 sections |