asfotase alfa Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
enzymes 5049 1174277-80-5

Description:

MoleculeDescription

Synonyms:

  • asfotase alpha
  • asfotase alfa
  • ALXN1215
  • ENB-0040
  • alkaline phosphatase
  • strensiq
  • ALXN-1215
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 28, 2015 EMA Alexion Europe SAS
Oct. 23, 2015 FDA ALEXION PHARM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Injection site reaction 57.93 55.97 17 196 47832 46638017

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC A16AB13 ALIMENTARY TRACT AND METABOLISM
OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
Enzymes
FDA CS M0000712 Alkaline Phosphatase
FDA EPC N0000191865 Tissue-nonspecific Alkaline Phosphatase

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypophosphatasia indication 190859005 DOID:14213

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
Z633861EIM UNII
D10595 KEGG_DRUG
4035009 VANDF
C0201850 UMLSCUI
CHEMBL2108311 ChEMBL_ID
DB05768 DRUGBANK_ID
DB09105 DRUGBANK_ID
D000469 MESH_DESCRIPTOR_UI
9269 INN_ID
C570710 MESH_SUPPLEMENTAL_RECORD_UI
11363176 PUBCHEM_CID
1720259 RXNORM
236660 MMSL
31258 MMSL
d08390 MMSL
016528 NDDF
57056007 SNOMEDCT_US
715255009 SNOMEDCT_US
715617005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
STRENSIQ HUMAN PRESCRIPTION DRUG LABEL 1 25682-010 SOLUTION 18 mg SUBCUTANEOUS BLA 31 sections
STRENSIQ HUMAN PRESCRIPTION DRUG LABEL 1 25682-013 SOLUTION 28 mg SUBCUTANEOUS BLA 31 sections
STRENSIQ HUMAN PRESCRIPTION DRUG LABEL 1 25682-016 SOLUTION 40 mg SUBCUTANEOUS BLA 31 sections
STRENSIQ HUMAN PRESCRIPTION DRUG LABEL 1 25682-019 SOLUTION 80 mg SUBCUTANEOUS BLA 31 sections