asfotase alfa 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
enzymes	5049	1174277-80-5

Description:

Molecule	Description
Synonyms: asfotase alpha asfotase alfa ALXN1215 ENB-0040 alkaline phosphatase strensiq ALXN-1215	An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

asfotase alpha
asfotase alfa
ALXN1215
ENB-0040
alkaline phosphatase
strensiq
ALXN-1215

An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Aug. 28, 2015	EMA	Alexion Europe SAS
Oct. 23, 2015	FDA	ALEXION PHARM

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Injection site reaction	84.13	36.32	28	550	58496	63429948
Injection site pain	78.95	36.32	33	545	129767	63358677
Injection site erythema	67.26	36.32	26	552	83148	63405296

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FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	A16AB13	ALIMENTARY TRACT AND METABOLISM OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS Enzymes
FDA CS	M0000712	Alkaline Phosphatase
FDA EPC	N0000191865	Tissue-nonspecific Alkaline Phosphatase

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Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypophosphatasia	indication	190859005	DOID:14213

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
016528	NDDF
11363176	PUBCHEM_CID
1720259	RXNORM
236660	MMSL
31258	MMSL
4035009	VANDF
57056007	SNOMEDCT_US
715255009	SNOMEDCT_US
715617005	SNOMEDCT_US
9269	INN_ID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
STRENSIQ	HUMAN PRESCRIPTION DRUG LABEL	1	25682-010	SOLUTION	18 mg	SUBCUTANEOUS	BLA	31 sections
STRENSIQ	HUMAN PRESCRIPTION DRUG LABEL	1	25682-010	SOLUTION	18 mg	SUBCUTANEOUS	BLA	31 sections
STRENSIQ	HUMAN PRESCRIPTION DRUG LABEL	1	25682-013	SOLUTION	28 mg	SUBCUTANEOUS	BLA	31 sections
STRENSIQ	HUMAN PRESCRIPTION DRUG LABEL	1	25682-013	SOLUTION	28 mg	SUBCUTANEOUS	BLA	31 sections
STRENSIQ	HUMAN PRESCRIPTION DRUG LABEL	1	25682-016	SOLUTION	40 mg	SUBCUTANEOUS	BLA	31 sections
STRENSIQ	HUMAN PRESCRIPTION DRUG LABEL	1	25682-016	SOLUTION	40 mg	SUBCUTANEOUS	BLA	31 sections
STRENSIQ	HUMAN PRESCRIPTION DRUG LABEL	1	25682-019	SOLUTION	80 mg	SUBCUTANEOUS	BLA	31 sections
STRENSIQ	HUMAN PRESCRIPTION DRUG LABEL	1	25682-019	SOLUTION	80 mg	SUBCUTANEOUS	BLA	31 sections

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