pimitespib 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| heat shock protein (HSP) 90 inhibitors (other than –mycin) | 5686 | 1260533-36-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Pimitespib is an oral small molecule inhibitor of the alpha and beta isoforms of heat shock protein 90 (HSP90).
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| June 20, 2022 | PMDA | TAIHO PHARMACEUTICAL CO., LTD |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Gastrointestinal stromal tumor | indication | 420120006 | DOID:9253 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Heat shock protein HSP 90-alpha | Cytosolic other | INHIBITOR | Ki | 7.46 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Heat shock protein HSP 90-beta | Cytosolic other | INHIBITOR | Ki | 7.67 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| CHEMBL3661115 | ChEMBL_ID |
| C000596495 | MESH_SUPPLEMENTAL_RECORD_UI |
| 12284 | IUPHAR_LIGAND_ID |
| DB14876 | DRUGBANK_ID |
| C5418185 | UMLSCUI |
| 11079 | INN_ID |
| D11920 | KEGG_DRUG |
| 67501411 | PUBCHEM_CID |
| PLO044MUDZ | UNII |
Pharmaceutical products:
None