tixagevimab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antiviral, monoclonal antibodies 5683 2420564-02-7

Description:

MoleculeDescription

Molfile

Synonyms:

  • tixagevimab
  • tixagevimab (genetical recombination)
  • AZD8895
  • COV2-2196
  • evusheld
Tixagevimab is a recombinant human IgG1 monoclonal antibody used in combination with cilgavimab for the treatment of COVID-19.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 25, 2022 EMA AstraZeneca AB
Aug. 30, 2022 PMDA AstraZeneca K.K.

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic epidermal necrolysis 45.60 35.88 7 3 21639 34935282

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J06BD03 ANTIINFECTIVES FOR SYSTEMIC USE
IMMUNE SERA AND IMMUNOGLOBULINS
IMMUNOGLOBULINS
Antiviral monoclonal antibodies
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000998 Antiviral Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
COVID-19 indication 840539006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Spike glycoprotein Glycoprotein BINDING AGENT Kd 11.56 DRUG LABEL DRUG LABEL

External reference:

IDSource
CHEMBL4650265 ChEMBL_ID
C000714167 MESH_SUPPLEMENTAL_RECORD_UI
C000714187 MESH_SUPPLEMENTAL_RECORD_UI
C000714168 MESH_SUPPLEMENTAL_RECORD_UI
11330 IUPHAR_LIGAND_ID
DB16394 DRUGBANK_ID
018902 NDDF
4041036 VANDF
C5432264 UMLSCUI
11776 INN_ID
D11993 KEGG_DRUG
2587300 RXNORM
353927 MMSL
40135 MMSL
d09834 MMSL
F0LZ415Z3B UNII

Pharmaceutical products:

None