All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

lutetium (177Lu) chloride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	5682	16434-14-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: lutetium (177Lu) chloride lumark illuzyce	Lutetium (177 Lu) chloride is a radiopharmaceutical precursor, and it is not intended for direct use in patients. It is to be used only for the radiolabelling of carrier molecules that have been specifically developed and authorised for radiolabelling with lutetium (177 Lu) chloride. Molecular weight: 283.29 Formula: Cl3Lu CLOGP: -1.32 LIPINSKI: 0 HAC: 0 HDO: 0 TPSA: ALOGS: -0.86 ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
June 18, 2015	EMA	I.D.B. Radiopharmacy B.V.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	500.84	9.47	1375	174312	1043390	62269945
Pemphigus	476.49	9.47	6	175681	183720	63129615
Hand deformity	382.95	9.47	13	175674	159444	63153891
Systemic lupus erythematosus	380.70	9.47	61	175626	208857	63104478
Contraindicated product administered	332.56	9.47	95	175592	217553	63095782
Glossodynia	326.38	9.47	52	175635	178824	63134511
Cardiac failure congestive	291.99	9.47	730	174957	91703	63221632
Anti-cyclic citrullinated peptide antibody positive	291.98	9.47	6	175681	116206	63197129
Pericarditis	269.81	9.47	26	175661	131553	63181782
Maternal exposure during pregnancy	252.21	9.47	148	175539	219914	63093421
Wound	247.96	9.47	72	175615	163191	63150144
Alopecia	214.97	9.47	378	175309	337158	62976177
Rheumatoid factor positive	213.45	9.47	4	175683	84402	63228933
Duodenal ulcer perforation	206.23	9.47	8	175679	87201	63226134
Discomfort	196.82	9.47	109	175578	167265	63146070
Hypokalaemia	196.28	9.47	683	175004	103121	63210214
Rheumatoid arthritis	195.74	9.47	249	175438	253570	63059765
Therapeutic product effect decreased	190.59	9.47	153	175534	193034	63120301
Helicobacter infection	183.34	9.47	21	175666	92764	63220571
Joint swelling	181.75	9.47	398	175289	327268	62986067
Abdominal discomfort	166.47	9.47	404	175283	320481	62992854
Synovitis	160.67	9.47	168	175519	186750	63126585
Sedation complication	156.09	9.47	192	175495	13630	63299705
Atrial fibrillation	155.88	9.47	688	174999	115948	63197387
Product use issue	154.27	9.47	232	175455	220288	63093047
Pneumonia	153.43	9.47	1933	173754	454834	62858501
Blood potassium decreased	153.19	9.47	351	175336	41675	63271660
Drug intolerance	151.27	9.47	400	175287	308261	63005074
Creatinine renal clearance decreased	150.47	9.47	205	175482	16103	63297232
Infusion related reaction	149.01	9.47	283	175404	245238	63068097
Folliculitis	146.50	9.47	13	175674	70304	63243031
Colitis microscopic	144.98	9.47	153	175534	9186	63304149
Hypervolaemia	144.32	9.47	272	175415	28141	63285194
Blood calcium decreased	144.13	9.47	261	175426	26190	63287145
Arthropathy	141.28	9.47	272	175415	234520	63078815
Toxic anterior segment syndrome	140.01	9.47	77	175610	1694	63311641
Constipation	139.84	9.47	1083	174604	223860	63089475
Oedema peripheral	138.81	9.47	949	174738	188562	63124773
Pulmonary hypertension	137.46	9.47	312	175375	36811	63276524
Swelling	136.33	9.47	355	175332	275023	63038312
Muscle injury	133.68	9.47	13	175674	65332	63248003
Dehydration	130.47	9.47	874	174813	172480	63140855
Hepatic enzyme increased	127.37	9.47	228	175459	202100	63111235
Plasma cell myeloma	126.59	9.47	296	175391	35609	63277726
Hypersensitivity	125.40	9.47	404	175283	292281	63021054
Off label use	119.25	9.47	1243	174444	673219	62640116
Hyperkalaemia	118.77	9.47	375	175312	53828	63259507
Exposure during pregnancy	118.36	9.47	154	175533	155393	63157942
Lower respiratory tract infection	118.13	9.47	115	175572	132192	63181143
Hypotension	118.12	9.47	1213	174474	271391	63041944
Orthostatic hypotension	116.63	9.47	288	175399	35872	63277463
Anaemia	103.55	9.47	1254	174433	292176	63021159
Fall	101.89	9.47	1587	174100	390747	62922588
Rheumatic fever	101.75	9.47	4	175683	43107	63270228
Acute respiratory failure	100.15	9.47	264	175423	34221	63279114
Irritable bowel syndrome	93.50	9.47	56	175631	82356	63230979
Diarrhoea	93.43	9.47	2614	173073	712752	62600583
Bronchitis	93.41	9.47	629	175058	124306	63189029
Hypoxia	93.35	9.47	370	175317	59422	63253913
Rash	92.05	9.47	1051	174636	559820	62753515
Treatment failure	91.41	9.47	266	175421	198777	63114558
Sepsis	90.54	9.47	729	174958	152394	63160941
Arthralgia	86.81	9.47	1085	174602	568625	62744710
Swollen joint count increased	86.28	9.47	3	175684	36051	63277284
Ill-defined disorder	84.06	9.47	62	175625	81693	63231642
Pulmonary arterial hypertension	83.85	9.47	190	175497	22387	63290948
Musculoskeletal stiffness	83.84	9.47	248	175439	184370	63128965
Glaucoma	81.53	9.47	169	175518	18736	63294599
Chronic obstructive pulmonary disease	80.85	9.47	366	175321	62320	63251015
Impaired healing	80.61	9.47	99	175588	102443	63210892
Intentional product use issue	79.65	9.47	145	175542	127747	63185588
Asthenia	78.99	9.47	1495	174192	382109	62931226
Cytokine release syndrome	78.94	9.47	142	175545	14172	63299163
Fluid retention	78.86	9.47	351	175336	59335	63254000
Dyspnoea	78.17	9.47	2387	173300	658926	62654409
Gastrointestinal haemorrhage	77.24	9.47	435	175252	80741	63232594
Right ventricular failure	76.89	9.47	156	175531	17032	63296303
Product residue present	76.11	9.47	73	175614	3906	63309429
Pneumonia aspiration	74.77	9.47	238	175449	34302	63279033
Psoriatic arthropathy	74.45	9.47	86	175601	91434	63221901
Respiratory failure	73.84	9.47	509	175178	101349	63211986
Gastrooesophageal reflux disease	71.76	9.47	482	175205	95157	63218178
Urinary tract infection	71.02	9.47	1077	174610	263607	63049728
Deep vein thrombosis	69.40	9.47	433	175254	83367	63229968
Diverticulitis	69.33	9.47	254	175433	39303	63274032
Balance disorder	69.16	9.47	435	175252	83987	63229348
Sedation	68.69	9.47	250	175437	38559	63274776
Blister	66.74	9.47	164	175523	129650	63183685
Cognitive disorder	64.02	9.47	315	175372	55500	63257835
Macular degeneration	63.18	9.47	179	175508	24197	63289138
Device expulsion	59.62	9.47	12	175675	34910	63278425
Liver injury	58.29	9.47	49	175638	60471	63252864
Drug abuse	58.06	9.47	69	175618	72449	63240886
Pleural effusion	57.93	9.47	449	175238	92761	63220574
Drug hypersensitivity	56.54	9.47	568	175119	310119	63003216
Methaemoglobinaemia	55.52	9.47	49	175638	2354	63310981
Abortion spontaneous	55.04	9.47	31	175656	47164	63266171
Completed suicide	54.98	9.47	212	175475	145461	63167874
Multiple allergies	54.45	9.47	119	175568	13683	63299652
Renal failure	53.96	9.47	530	175157	117122	63196213
International normalised ratio increased	53.95	9.47	263	175424	46162	63267173
Hip arthroplasty	53.17	9.47	33	175654	47613	63265722
Gastrointestinal disorder	52.13	9.47	187	175500	131052	63182283
Gastrointestinal toxicity	50.85	9.47	83	175604	7658	63305677
Acute kidney injury	49.54	9.47	1013	174674	262402	63050933
White blood cell count decreased	49.18	9.47	595	175092	138509	63174826
Suicide attempt	47.67	9.47	59	175628	60859	63252476
Thrombosis	47.15	9.47	324	175363	64431	63248904
Full blood count decreased	45.51	9.47	167	175520	25857	63287478
Death	45.02	9.47	1355	174332	373026	62940309
Pulmonary toxicity	44.92	9.47	88	175599	9367	63303968
Intentional self-injury	43.49	9.47	9	175678	25678	63287657
Dementia	42.97	9.47	132	175555	18662	63294673
Mental status changes	42.95	9.47	220	175467	39379	63273956
Blood cholesterol increased	42.16	9.47	127	175560	93905	63219430
Pulmonary oedema	42.01	9.47	278	175409	54595	63258740
Pain	41.11	9.47	1655	174032	738973	62574362
Platelet count decreased	40.73	9.47	496	175191	115626	63197709
Product use in unapproved indication	40.23	9.47	310	175377	178770	63134565
Multiple drug therapy	40.12	9.47	50	175637	3596	63309739
Depressed level of consciousness	39.66	9.47	301	175386	61777	63251558
Intentional overdose	39.43	9.47	92	175595	74060	63239275
Haemoglobin decreased	38.58	9.47	591	175096	144894	63168441
Electrolyte imbalance	37.81	9.47	132	175555	19944	63293391
Dyspnoea exertional	37.19	9.47	290	175397	60012	63253323
Nasopharyngitis	36.44	9.47	490	175197	253767	63059568
Neuropathy peripheral	35.41	9.47	475	175212	113192	63200143
Cardiomegaly	35.09	9.47	118	175569	17496	63295839
Brain natriuretic peptide increased	34.39	9.47	56	175631	5157	63308178
Cor pulmonale	34.31	9.47	35	175652	2019	63311316
Stomatitis	34.11	9.47	234	175453	138491	63174844
Emphysema	34.08	9.47	86	175601	10852	63302483
Pregnancy	34.05	9.47	31	175656	36805	63276530
Syncope	33.52	9.47	483	175204	116902	63196433
Pulmonary embolism	33.27	9.47	480	175207	116204	63197131
General physical health deterioration	33.05	9.47	377	175310	201025	63112310
Peritonitis bacterial	32.98	9.47	53	175634	4826	63308509
Weight decreased	32.74	9.47	1000	174687	275798	63037537
Chronic sinusitis	32.01	9.47	93	175594	12750	63300585
Drug eruption	31.84	9.47	20	175667	28674	63284661
Blood urea increased	31.77	9.47	151	175536	26228	63287107
Atrial flutter	31.68	9.47	78	175609	9694	63303641
Urticaria	31.43	9.47	300	175387	165502	63147833
Cellulitis	31.36	9.47	356	175331	81602	63231733
Foetal exposure during pregnancy	29.42	9.47	27	175660	31935	63281400
Hiatus hernia	29.28	9.47	128	175559	21466	63291869
Neoplasm malignant	29.04	9.47	161	175526	29700	63283635
Transfusion	28.61	9.47	100	175587	15117	63298218
Ascites	28.60	9.47	202	175485	40526	63272809
Endophthalmitis	28.47	9.47	42	175645	3550	63309785
Grip strength decreased	28.44	9.47	13	175674	22274	63291061
Decreased appetite	28.10	9.47	901	174786	250151	63063184
Oedema	27.99	9.47	402	175285	97220	63216115
Joint range of motion decreased	27.99	9.47	29	175658	32399	63280936
Blood alkaline phosphatase increased	27.81	9.47	209	175478	42758	63270577
Cardiac failure	27.55	9.47	372	175315	88770	63224565
Colitis	27.54	9.47	229	175458	48299	63265036
Prothrombin time prolonged	27.54	9.47	73	175614	9491	63303844
Type 2 diabetes mellitus	27.39	9.47	88	175599	63780	63249555
Chest pain	27.37	9.47	787	174900	215172	63098163
Rheumatoid nodule	27.08	9.47	7	175680	17148	63296187
Blood magnesium decreased	26.81	9.47	89	175598	13109	63300226
Clostridium difficile colitis	26.43	9.47	120	175567	20449	63292886
Body height decreased	26.11	9.47	74	175613	10004	63303331
Psoriasis	25.93	9.47	138	175549	86819	63226516
Toxicity to various agents	25.93	9.47	505	175182	246745	63066590
Pulmonary fibrosis	25.79	9.47	44	175643	39765	63273570
Lymphoedema	25.70	9.47	81	175606	11611	63301724
Blood glucose increased	25.66	9.47	349	175338	83407	63229928
Injection site reaction	25.55	9.47	80	175607	58444	63254891
Thyroid disorder	25.43	9.47	96	175591	15066	63298269
Injection site swelling	25.31	9.47	59	175628	47513	63265822
Adverse event	25.04	9.47	99	175588	67460	63245875
Febrile neutropenia	24.75	9.47	463	175224	117986	63195349
Knee arthroplasty	24.44	9.47	73	175614	54133	63259202
Hepatocellular injury	24.19	9.47	24	175663	27357	63285978
Loss of personal independence in daily activities	23.96	9.47	164	175523	97126	63216209
Cardiac arrest	23.77	9.47	374	175313	92171	63221164
Prescribed overdose	23.77	9.47	36	175651	34117	63279218
Paraesthesia oral	23.75	9.47	111	175576	19145	63294190
Inflammation	23.74	9.47	132	175555	82141	63231194
Hypophagia	23.70	9.47	158	175529	31101	63282234
Condition aggravated	23.70	9.47	892	174795	401325	62912010
Haematocrit decreased	23.60	9.47	188	175499	39152	63274183
Skin reaction	23.25	9.47	92	175595	14757	63298578
Blood bilirubin increased	23.11	9.47	179	175508	36961	63276374
Female genital tract fistula	23.10	9.47	59	175628	7500	63305835
Disability	22.95	9.47	11	175676	18336	63294999
Joint injury	22.74	9.47	150	175537	29422	63283913
Coeliac disease	22.69	9.47	4	175683	12793	63300542
Drug tolerance decreased	22.60	9.47	10	175677	17463	63295872
Injection site pain	22.46	9.47	240	175447	129560	63183775
Calcium deficiency	22.38	9.47	21	175666	1093	63312242
Drug reaction with eosinophilia and systemic symptoms	22.29	9.47	37	175650	33799	63279536
Laboratory test abnormal	22.23	9.47	139	175548	26773	63286562
Oxygen consumption increased	22.02	9.47	39	175648	3845	63309490
Blood immunoglobulin M increased	21.92	9.47	21	175666	1122	63312213
Pneumonia streptococcal	21.82	9.47	26	175661	1785	63311550
Hypomagnesaemia	21.64	9.47	145	175542	28592	63284743
Fibromyalgia	21.62	9.47	132	175555	80288	63233047
Blood potassium abnormal	21.57	9.47	31	175656	2559	63310776
Coagulopathy	21.49	9.47	113	175574	20431	63292904
Injection site bruising	21.48	9.47	53	175634	41857	63271478
Hepatitis	21.44	9.47	49	175638	39739	63273596
Gout	21.41	9.47	83	175604	13188	63300147
Product dose omission issue	21.26	9.47	821	174866	233492	63079843
Cholelithiasis	21.17	9.47	200	175487	43725	63269610
Cerebrovascular accident	21.12	9.47	418	175269	107606	63205729
Therapeutic response decreased	21.03	9.47	93	175594	61432	63251903
Diverticulum	21.01	9.47	77	175610	11914	63301421
Atelectasis	21.00	9.47	116	175571	21367	63291968
Acute left ventricular failure	20.71	9.47	20	175667	1079	63312256
Arrhythmia	20.59	9.47	178	175509	37962	63275373
Procedural complication	20.45	9.47	46	175641	5393	63307942
Chronic respiratory failure	20.31	9.47	26	175661	1921	63311414
Wrong technique in product usage process	20.26	9.47	96	175591	62244	63251091
Copper deficiency	20.18	9.47	8	175679	80	63313255
Vaginal flatulence	19.88	9.47	34	175653	3259	63310076
Failure to thrive	19.78	9.47	54	175633	7144	63306191
Blood pressure fluctuation	19.74	9.47	64	175623	46253	63267082
Tonsillar haemorrhage	19.68	9.47	11	175676	250	63313085
Urine chloride decreased	19.59	9.47	8	175679	87	63313248
Unevaluable event	19.56	9.47	223	175464	51163	63262172
Blood loss anaemia	19.45	9.47	62	175625	8939	63304396
Blood potassium increased	19.35	9.47	101	175586	18208	63295127
Tenosynovitis	19.30	9.47	7	175680	13788	63299547
Pneumothorax spontaneous	19.26	9.47	17	175670	817	63312518
Hypovolaemia	19.09	9.47	69	175618	10604	63302731
Facet joint syndrome	19.07	9.47	5	175682	12133	63301202
Sleep apnoea syndrome	19.02	9.47	142	175545	28991	63284344
Metabolic alkalosis	19.01	9.47	32	175655	3029	63310306
Peripheral circulatory failure	18.97	9.47	18	175669	950	63312385
Accidental exposure to product	18.97	9.47	29	175658	27376	63285959
Supraventricular tachycardia	18.90	9.47	84	175603	14187	63299148
Sleep disorder	18.87	9.47	140	175547	81426	63231909
Live birth	18.84	9.47	26	175661	25604	63287731
Foot deformity	18.77	9.47	30	175657	27823	63285512
Generalised oedema	18.65	9.47	90	175597	15728	63297607
Respiratory distress	18.62	9.47	159	175528	33792	63279543
Small intestinal obstruction	18.59	9.47	100	175587	18237	63295098
Oesophageal spasm	18.54	9.47	32	175655	3091	63310244
Adjustment disorder with depressed mood	18.51	9.47	3	175684	10201	63303134
Electrocardiogram T wave peaked	18.47	9.47	10	175677	213	63313122
Seasonal allergy	18.44	9.47	110	175577	20840	63292495
Leukocytosis	18.42	9.47	129	175558	25806	63287529
Hospice care	18.40	9.47	56	175631	7876	63305459
Serotonin syndrome	18.31	9.47	32	175655	28650	63284685
Blood albumin decreased	18.13	9.47	85	175602	14681	63298654
Blood pressure diastolic increased	18.03	9.47	3	175684	10007	63303328
Posterior reversible encephalopathy syndrome	18.02	9.47	13	175674	17332	63296003
Injection site erythema	17.73	9.47	146	175541	83028	63230307
Blood immunoglobulin A decreased	17.70	9.47	20	175667	1297	63312038
Blood cholesterol decreased	17.45	9.47	17	175670	927	63312408
Adverse drug reaction	17.41	9.47	139	175548	79575	63233760
Anterior chamber inflammation	17.38	9.47	11	175676	316	63313019
Skin odour abnormal	16.99	9.47	22	175665	1644	63311691
Electrocardiogram abnormal	16.98	9.47	60	175627	9119	63304216
Bezoar	16.91	9.47	21	175666	1505	63311830
Hyponatraemia	16.80	9.47	417	175270	111483	63201852
Cataract operation	16.77	9.47	43	175644	5479	63307856
Septic shock	16.63	9.47	268	175419	66361	63246974
Therapeutic product effect incomplete	16.48	9.47	245	175442	124811	63188524
Polyneuropathy	16.42	9.47	10	175677	14579	63298756
Metabolic encephalopathy	16.38	9.47	44	175643	5765	63307570
Blood pressure diastolic abnormal	16.32	9.47	10	175677	14532	63298803
Candida infection	16.20	9.47	134	175553	28217	63285118
Proctitis	16.15	9.47	42	175645	5399	63307936
Nail dystrophy	16.03	9.47	17	175670	1026	63312309
Pancytopenia	16.01	9.47	366	175321	96567	63216768
Blood immunoglobulin G increased	15.91	9.47	26	175661	2401	63310934
Pre-eclampsia	15.88	9.47	3	175684	9130	63304205
Oesophageal pain	15.86	9.47	33	175654	3668	63309667
Impaired work ability	15.80	9.47	15	175672	17460	63295875
Lipoedema	15.78	9.47	10	175677	288	63313047
Immune effector cell-associated neurotoxicity syndrome	15.76	9.47	25	175662	2252	63311083
Epilepsy	15.69	9.47	32	175655	27033	63286302
Catheter management	15.67	9.47	29	175658	2958	63310377
Arthritis	15.66	9.47	226	175461	115695	63197640
Disease progression	15.43	9.47	447	175240	122311	63191024
Night sweats	15.38	9.47	76	175611	48738	63264597
Activated partial thromboplastin time prolonged	15.37	9.47	48	175639	6845	63306490
Coma	15.36	9.47	257	175430	64107	63249228
Red blood cell sedimentation rate increased	15.33	9.47	66	175621	43916	63269419
Polymyalgia rheumatica	15.31	9.47	33	175654	3758	63309577
Diastolic dysfunction	15.31	9.47	46	175641	6425	63306910
Drug ineffective for unapproved indication	15.27	9.47	46	175641	34017	63279318
Paracentesis	15.25	9.47	16	175671	954	63312381
Malnutrition	15.22	9.47	83	175604	15215	63298120
Urine sodium decreased	15.10	9.47	8	175679	163	63313172
Infusion site extravasation	15.06	9.47	63	175624	10363	63302972
Necrosis ischaemic	15.00	9.47	15	175672	845	63312490
Suicidal ideation	14.98	9.47	106	175581	62315	63251020
Cardiac failure acute	14.91	9.47	59	175628	9464	63303871
Confusional state	14.85	9.47	520	175167	235860	63077475
Pulmonary pain	14.81	9.47	31	175656	3459	63309876
Blood glucose decreased	14.75	9.47	104	175583	20848	63292487
Lung infiltration	14.75	9.47	79	175608	14384	63298951
Infection	14.66	9.47	503	175184	228670	63084665
Blood chloride decreased	14.66	9.47	41	175646	5501	63307834
Enthesopathy	14.62	9.47	3	175684	8611	63304724
Injury	14.53	9.47	131	175556	73116	63240219
Rectal haemorrhage	14.49	9.47	203	175484	48827	63264508
Headache	14.47	9.47	1533	174154	631708	62681627
Haematotoxicity	14.47	9.47	4	175683	9372	63303963
Thyroxine decreased	14.46	9.47	13	175674	640	63312695
Coronary artery disease	14.41	9.47	145	175542	32232	63281103
Orthopnoea	14.34	9.47	44	175643	6217	63307118
Drug resistance	14.26	9.47	26	175661	22907	63290428
Peptic ulcer	14.22	9.47	36	175651	4551	63308784
Hypercapnia	14.19	9.47	40	175647	5391	63307944
Gastric polyps	14.17	9.47	30	175657	3375	63309960
Device difficult to use	14.08	9.47	9	175678	12787	63300548
Skin candida	14.06	9.47	20	175667	1635	63311700
Schizophrenia	14.01	9.47	5	175682	9947	63303388
Panniculitis	13.98	9.47	7	175680	11378	63301957
Blood pressure systolic abnormal	13.95	9.47	10	175677	13376	63299959
Eyelid margin crusting	13.93	9.47	16	175671	1056	63312279
Mental status changes postoperative	13.92	9.47	8	175679	192	63313143
Skin laceration	13.88	9.47	109	175578	22599	63290736
Chronic kidney disease	13.83	9.47	189	175498	45209	63268126
Amyloid arthropathy	13.75	9.47	12	175675	568	63312767
Epistaxis	13.74	9.47	280	175407	72445	63240890
Beta haemolytic streptococcal infection	13.69	9.47	22	175665	2003	63311332
Tricuspid valve incompetence	13.66	9.47	78	175609	14543	63298792
Cataract operation complication	13.65	9.47	7	175680	133	63313202
Mitral valve incompetence	13.65	9.47	97	175590	19497	63293838
Neuroglycopenia	13.62	9.47	11	175676	467	63312868
Poisoning deliberate	13.62	9.47	7	175680	11211	63302124
Haemorrhage	13.61	9.47	241	175446	60781	63252554
Pericardial effusion	13.57	9.47	135	175552	29923	63283412
Sinus disorder	13.47	9.47	115	175572	24438	63288897
Procedural pain	13.44	9.47	104	175583	21465	63291870
Polyuria	13.44	9.47	53	175634	8489	63304846
Clostridium difficile infection	13.32	9.47	134	175553	29788	63283547
Overdose	13.31	9.47	231	175456	114847	63198488
Poisoning	13.30	9.47	11	175676	13689	63299646
Pain in jaw	13.22	9.47	181	175506	43315	63270020
Pulmonary arterial pressure increased	13.06	9.47	30	175657	3565	63309770
Bone erosion	12.99	9.47	18	175669	17699	63295636
Atrioventricular block first degree	12.99	9.47	47	175640	7226	63306109
Incision site pain	12.93	9.47	16	175671	1142	63312193
Cystitis	12.91	9.47	219	175468	54772	63258563
Salpingo-oophorectomy unilateral	12.91	9.47	14	175673	867	63312468
Nodal arrhythmia	12.88	9.47	16	175671	1147	63312188
Pseudomonal bacteraemia	12.85	9.47	19	175668	1609	63311726
Head injury	12.83	9.47	124	175563	27272	63286063
Hydronephrosis	12.81	9.47	61	175626	10601	63302734
Aortic valve disease	12.79	9.47	16	175671	1155	63312180
Blood creatinine increased	12.78	9.47	326	175361	87518	63225817
Feeling abnormal	12.75	9.47	517	175170	147875	63165460
Sinus node dysfunction	12.73	9.47	35	175652	4650	63308685
Transplant rejection	12.69	9.47	7	175680	10773	63302562
Occult blood positive	12.65	9.47	30	175657	3640	63309695
Premature ageing	12.61	9.47	3	175684	3	63313332
Arteriovenous malformation	12.40	9.47	17	175670	1343	63311992
Confusion postoperative	12.39	9.47	8	175679	238	63313097
Red blood cell count decreased	12.30	9.47	169	175518	40476	63272859
Adenocarcinoma	12.28	9.47	26	175661	2924	63310411
Gestational diabetes	12.20	9.47	4	175683	8392	63304943
Post procedural complication	12.17	9.47	85	175602	16989	63296346
Lip dry	12.08	9.47	15	175672	15455	63297880
Acquired diaphragmatic eventration	12.04	9.47	10	175677	442	63312893
Diverticulum intestinal haemorrhagic	12.01	9.47	18	175669	1543	63311792
Anhedonia	11.92	9.47	61	175626	10913	63302422
Myocardial infarction	11.81	9.47	361	175326	99532	63213803
Hypernatraemia	11.80	9.47	47	175640	7562	63305773
Lupus-like syndrome	11.77	9.47	15	175672	15280	63298055
Foetal death	11.71	9.47	8	175679	10972	63302363
Hernia	11.70	9.47	67	175620	12507	63300828
Skin dystrophy	11.66	9.47	5	175682	62	63313273
Gastritis	11.65	9.47	156	175531	37147	63276188
Chronic left ventricular failure	11.64	9.47	10	175677	463	63312872
Arteriosclerosis coronary artery	11.63	9.47	50	175637	8323	63305012
Blood pressure systolic increased	11.62	9.47	80	175607	47317	63266018
Pulse absent	11.60	9.47	37	175650	5337	63307998
Pharyngitis	11.52	9.47	24	175663	20119	63293216
Bursitis	11.48	9.47	58	175629	36983	63276352
Erythema multiforme	11.40	9.47	7	175680	10162	63303173
Anterior chamber disorder	11.29	9.47	6	175681	123	63313212
Lymphopenia	11.20	9.47	21	175666	18306	63295029
Muscle spasms	11.20	9.47	534	175153	155616	63157719
Hereditary angioedema	11.16	9.47	46	175641	7516	63305819
Staphylococcal infection	11.08	9.47	168	175519	41088	63272247
Catheter site haemorrhage	11.00	9.47	26	175661	3149	63310186
Blood sodium decreased	10.98	9.47	109	175578	24143	63289192
Radiculopathy	10.89	9.47	50	175637	8561	63304774
Aspartate aminotransferase increased	10.87	9.47	327	175360	89950	63223385
Lower gastrointestinal haemorrhage	10.87	9.47	47	175640	7843	63305492
Thrombocytopenia	10.86	9.47	517	175170	150640	63162695
Vascular pseudoaneurysm	10.83	9.47	17	175670	1517	63311818
Application site necrosis	10.80	9.47	3	175684	8	63313327
Acne	10.77	9.47	31	175656	23262	63290073
Presyncope	10.76	9.47	121	175566	27664	63285671
Finger deformity	10.72	9.47	4	175683	7741	63305594
Ankylosing spondylitis	10.69	9.47	8	175679	10466	63302869
Chills	10.68	9.47	399	175288	112979	63200356
Biopsy bone abnormal	10.66	9.47	4	175683	34	63313301
Encephalopathy	10.65	9.47	158	175529	38462	63274873
Pulmonary thrombosis	10.61	9.47	50	175637	8652	63304683
Injection site warmth	10.59	9.47	16	175671	15179	63298156
Abortion incomplete complicated	10.54	9.47	3	175684	9	63313326
Deposit eye	10.54	9.47	3	175684	9	63313326
Pollakiuria	10.52	9.47	121	175566	27816	63285519
Blood albumin abnormal	10.52	9.47	10	175677	529	63312806
Cardiac aneurysm	10.52	9.47	13	175674	927	63312408
Hallucination, auditory	10.48	9.47	12	175675	12812	63300523
Colour blindness	10.47	9.47	8	175679	313	63313022
Norovirus infection	10.44	9.47	11	175676	659	63312676
Right atrial pressure increased	10.40	9.47	6	175681	145	63313190
Appetite disorder	10.39	9.47	44	175643	7277	63306058
Hyperlipidaemia	10.39	9.47	91	175596	19480	63293855
Haemorrhagic arteriovenous malformation	10.37	9.47	6	175681	146	63313189
Neonatal infection	10.33	9.47	6	175681	147	63313188
Angioedema	10.31	9.47	84	175603	47881	63265454
Heparin-induced thrombocytopenia	10.31	9.47	32	175655	4550	63308785
Cardiac amyloidosis	10.23	9.47	12	175675	810	63312525
Bladder spasm	10.19	9.47	18	175669	1770	63311565
Ageusia	10.17	9.47	69	175618	13659	63299676
Injection site pruritus	10.16	9.47	78	175609	45038	63268297
Neuroleptic malignant syndrome	10.16	9.47	11	175676	12045	63301290
Micturition disorder	10.14	9.47	22	175665	2516	63310819
Prescribed underdose	10.07	9.47	45	175642	29644	63283691
Product substitution issue	10.07	9.47	18	175669	15978	63297357
Cardiac disorder	10.05	9.47	197	175490	50619	63262716
Oxygen therapy	10.02	9.47	20	175667	2158	63311177
Hyperaldosteronism	9.99	9.47	7	175680	239	63313096
Parkinsonism	9.96	9.47	56	175631	10383	63302952
Nasal congestion	9.94	9.47	245	175442	65415	63247920
Serratia sepsis	9.94	9.47	5	175682	91	63313244
Melaena	9.91	9.47	128	175559	30237	63283098
Ischaemic skin ulcer	9.83	9.47	4	175683	43	63313292
Brain contusion	9.83	9.47	10	175677	575	63312760
Psychomotor hyperactivity	9.82	9.47	9	175678	10654	63302681
Hypoalbuminaemia	9.76	9.47	61	175626	11744	63301591
Haemoptysis	9.76	9.47	122	175565	28604	63284731
Mediastinal mass	9.74	9.47	8	175679	348	63312987
Retinal ischaemia	9.74	9.47	8	175679	348	63312987
Oesophagitis	9.71	9.47	73	175614	14935	63298400
Electrocardiogram U wave present	9.70	9.47	5	175682	96	63313239
Infrapatellar fat pad inflammation	9.65	9.47	6	175681	167	63313168
Thrombotic microangiopathy	9.63	9.47	9	175678	10552	63302783
Blood aldosterone abnormal	9.60	9.47	4	175683	46	63313289
Device related sepsis	9.59	9.47	29	175658	4065	63309270
Carbon dioxide increased	9.59	9.47	15	175672	1335	63312000

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Prostatic specific antigen increased	408.26	10.28	341	102148	14339	34840103
Drug ineffective	257.70	10.28	603	101886	456148	34398294
Metastases to bone	193.82	10.28	206	102283	11764	34842678
Drug abuse	165.68	10.28	43	102446	99053	34755389
Toxic anterior segment syndrome	129.72	10.28	65	102424	1104	34853338
Cardiac failure congestive	118.44	10.28	521	101968	82749	34771693
Hypokalaemia	109.06	10.28	397	102092	57817	34796625
Toxicity to various agents	98.21	10.28	283	102206	200079	34654363
Metastases to liver	90.82	10.28	152	102337	13511	34840931
Haemoglobin decreased	75.65	10.28	609	101880	120163	34734279
Blood potassium decreased	74.18	10.28	163	102326	17752	34836690
Atrial fibrillation	73.87	10.28	612	101877	121781	34732661
Prostate cancer metastatic	73.65	10.28	88	102401	5715	34848727
Appendicolith	71.46	10.28	106	102383	8495	34845947
Drug interaction	66.72	10.28	389	102100	225557	34628885
Asthenia	64.11	10.28	1042	101447	244209	34610233
Suicide attempt	63.40	10.28	18	102471	39098	34815344
Oedema peripheral	62.38	10.28	580	101909	119232	34735210
Treatment failure	61.42	10.28	30	102459	46667	34807775
Therapeutic product effect incomplete	61.30	10.28	36	102453	50505	34803937
Abdominal distension	60.27	10.28	334	102155	58158	34796284
Anaemia	59.35	10.28	987	101502	232348	34622094
Cardiogenic shock	58.06	10.28	191	102298	26427	34828015
Ventricular fibrillation	55.81	10.28	171	102318	22783	34831659
Off label use	54.93	10.28	883	101606	418641	34435801
Foetal exposure during pregnancy	52.40	10.28	23	102466	38078	34816364
Hypervolaemia	51.87	10.28	151	102338	19558	34834884
Spinal cord compression	49.99	10.28	60	102429	3915	34850527
Bone pain	49.27	10.28	153	102336	20533	34833909
Hypotension	48.64	10.28	916	101573	220733	34633709
Metastases to lymph nodes	46.26	10.28	63	102426	4665	34849777
Blood phosphorus increased	46.20	10.28	82	102407	7639	34846803
Appendicitis	44.44	10.28	119	102370	14688	34839754
Fluid retention	44.24	10.28	176	102313	26711	34827731
Dehydration	44.06	10.28	578	101911	129391	34725051
Rheumatoid arthritis	43.93	10.28	29	102460	38209	34816233
Ascites	42.79	10.28	258	102231	46313	34808129
Dyspnoea	42.76	10.28	1424	101065	375358	34479084
Metastases to spine	40.99	10.28	44	102445	2540	34851902
Spinal muscular atrophy	40.96	10.28	21	102468	375	34854067
Cytokine release syndrome	40.28	10.28	153	102336	22724	34831718
Overdose	39.33	10.28	136	102353	90923	34763519
Hyperkalaemia	38.66	10.28	341	102148	69048	34785394
Intentional product use issue	36.72	10.28	75	102414	59741	34794701
Pathological fracture	36.31	10.28	54	102435	4337	34850105
Intentional overdose	36.02	10.28	45	102444	43629	34810813
Pneumonia	35.78	10.28	1349	101140	361278	34493164
Laboratory test abnormal	35.59	10.28	136	102353	20255	34834187
Methaemoglobinaemia	35.46	10.28	48	102441	3533	34850909
General physical health deterioration	35.30	10.28	550	101939	127719	34726723
Platelet count decreased	34.74	10.28	518	101971	119199	34735243
Right ventricular failure	34.20	10.28	78	102411	8706	34845736
Incision site pain	34.02	10.28	34	102455	1804	34852638
International normalised ratio increased	33.10	10.28	245	102244	47082	34807360
Stress	33.07	10.28	176	102313	30171	34824271
Acute respiratory failure	32.77	10.28	178	102311	30750	34823692
Plasma cell myeloma	31.35	10.28	221	102268	41816	34812626
Product use in unapproved indication	31.14	10.28	209	102280	117290	34737152
Mental status changes	30.65	10.28	204	102285	37879	34816563
Motor neurone disease	30.56	10.28	19	102470	498	34853944
Drug reaction with eosinophilia and systemic symptoms	30.51	10.28	31	102458	32981	34821461
Meningitis aseptic	30.10	10.28	42	102447	3182	34851260
Suicidal ideation	29.90	10.28	45	102444	40343	34814099
Intentional self-injury	29.58	10.28	3	102486	13768	34840674
Sepsis	28.52	10.28	664	101825	165897	34688545
Tachypnoea	28.49	10.28	118	102371	18234	34836208
Hepatocellular injury	28.11	10.28	15	102474	22196	34832246
Diaphragmatic spasm	27.58	10.28	11	102478	105	34854337
Prostate cancer stage IV	27.41	10.28	35	102454	2433	34852009
Metastases to bone marrow	27.40	10.28	18	102471	520	34853922
Cytomegalovirus infection	27.19	10.28	22	102467	26113	34828329
Stoma closure	26.58	10.28	14	102475	265	34854177
Faecal volume decreased	26.37	10.28	11	102478	119	34854323
Metastasis	26.08	10.28	45	102444	4099	34850343
Pulmonary hypertension	26.06	10.28	126	102363	20798	34833644
Cardiac failure	25.36	10.28	392	102097	90856	34763586
Blood urea increased	25.25	10.28	164	102325	30200	34824242
Pneumococcal sepsis	24.76	10.28	23	102466	1114	34853328
Loss of personal independence in daily activities	24.53	10.28	37	102452	33142	34821300
Psoriasis	24.38	10.28	48	102441	38764	34815678
Musculoskeletal stiffness	24.24	10.28	64	102425	46616	34807826
Sedation	24.03	10.28	16	102473	20990	34833452
Pulmonary arterial hypertension	24.00	10.28	68	102421	8671	34845771
Sputum increased	23.82	10.28	32	102457	2338	34852104
Eosinophilia	23.81	10.28	25	102464	26197	34828245
Urticaria	23.78	10.28	98	102391	62279	34792163
Aggression	22.95	10.28	50	102439	38914	34815528
Angioedema	22.81	10.28	47	102442	37327	34817115
Therapeutic product effect decreased	22.67	10.28	42	102447	34701	34819741
Chronic obstructive pulmonary disease	22.56	10.28	231	102258	48687	34805755
Epilepsy	22.48	10.28	18	102471	21477	34832965
Drug-induced liver injury	22.45	10.28	31	102458	28801	34825641
Death	22.30	10.28	1401	101088	396648	34457794
Drug resistance	22.13	10.28	26	102463	25901	34828541
Obstructive airways disorder	21.86	10.28	9	102480	15485	34838957
Ventricular tachycardia	21.76	10.28	143	102346	26436	34828006
Disease complication	21.70	10.28	33	102456	2703	34851739
Increased bronchial secretion	21.40	10.28	27	102462	1854	34852588
Product use issue	21.28	10.28	104	102385	63112	34791330
Fatigue	21.01	10.28	1306	101183	369347	34485095
Drug dependence	20.98	10.28	24	102465	24193	34830249
Glomerular filtration rate	20.90	10.28	9	102480	106	34854336
Blood pressure fluctuation	20.83	10.28	26	102463	25223	34829219
Cataract operation complication	20.71	10.28	10	102479	156	34854286
Osteonecrosis of jaw	20.35	10.28	105	102384	17784	34836658
Lung infiltration	20.05	10.28	83	102406	12822	34841620
C-reactive protein increased	19.99	10.28	86	102403	54012	34800430
Toxic epidermal necrolysis	19.92	10.28	120	102369	21526	34832916
Lymphadenectomy	19.84	10.28	13	102476	374	34854068
Rhinocerebral mucormycosis	19.64	10.28	15	102474	553	34853889
Cardiac disorder	19.58	10.28	203	102286	42923	34811519
Atrial flutter	19.55	10.28	94	102395	15480	34838962
Gastrointestinal haemorrhage	19.11	10.28	365	102124	88112	34766330
Traumatic fracture	19.05	10.28	12	102477	322	34854120
Atelectasis	18.76	10.28	102	102387	17625	34836817
Constipation	18.71	10.28	530	101959	136452	34717990
Therapy partial responder	18.48	10.28	3	102486	9613	34844829
Metastases to soft tissue	18.43	10.28	13	102476	423	34854019
Resuscitation	18.38	10.28	22	102467	1431	34853011
Electrocardiogram T wave amplitude decreased	18.17	10.28	12	102477	350	34854092
Hormone-refractory prostate cancer	18.14	10.28	16	102473	724	34853718
Headache	18.05	10.28	449	102040	200186	34654256
Blood test abnormal	17.95	10.28	53	102436	6918	34847524
Disease progression	17.91	10.28	429	102060	107648	34746794
Hypoxia	17.80	10.28	243	102246	54852	34799590
Therapeutic response decreased	17.77	10.28	37	102452	29276	34825166
Arthralgia	17.70	10.28	372	102117	169669	34684773
Product residue present	17.52	10.28	30	102459	2716	34851726
Scrotal oedema	17.36	10.28	24	102465	1802	34852640
Sopor	17.20	10.28	7	102482	12129	34842313
Serotonin syndrome	17.00	10.28	20	102469	19913	34834529
Transient aphasia	16.95	10.28	12	102477	393	34854049
Ventricular extrasystoles	16.93	10.28	75	102414	11933	34842509
Lower respiratory tract infection bacterial	16.82	10.28	13	102476	488	34853954
Blood alkaline phosphatase increased	16.73	10.28	152	102337	31023	34823419
Oedema	16.56	10.28	206	102283	45535	34808907
Therapeutic product effect prolonged	16.47	10.28	10	102479	251	34854191
Inappropriate schedule of product administration	16.39	10.28	111	102378	62185	34792257
Peri-implantitis	16.28	10.28	8	102481	130	34854312
Polyneuropathy	16.18	10.28	12	102477	14884	34839558
Hepatotoxicity	15.84	10.28	24	102465	21461	34832981
Exercise tolerance decreased	15.82	10.28	42	102447	5156	34849286
Bronchial disorder	15.74	10.28	20	102469	1383	34853059
Product substitution issue	15.71	10.28	5	102484	10090	34844352
Psoriatic arthropathy	15.70	10.28	21	102468	19777	34834665
Bone marrow infiltration	15.60	10.28	9	102480	205	34854237
Psychotic disorder	15.56	10.28	30	102459	24422	34830020
Cancer pain	15.50	10.28	28	102461	2644	34851798
Troponin T increased	15.25	10.28	26	102463	2345	34852097
Post procedural complication	15.22	10.28	70	102419	11318	34843124
Blood uric acid increased	15.03	10.28	62	102427	9562	34844880
Cellulitis	14.90	10.28	228	102261	52723	34801719
Heparin-induced thrombocytopenia	14.85	10.28	43	102446	5552	34848890
Body temperature decreased	14.81	10.28	10	102479	13024	34841418
Depressed mood	14.81	10.28	21	102468	19296	34835146
Haematocrit decreased	14.79	10.28	152	102337	32064	34822378
Insomnia	14.75	10.28	215	102274	103692	34750750
Failure to thrive	14.71	10.28	57	102432	8544	34845898
Blood alkaline phosphatase decreased	14.66	10.28	15	102474	819	34853623
Joint swelling	14.64	10.28	109	102380	59781	34794661
Metabolic disorder	14.48	10.28	36	102453	4247	34850195
Pain in jaw	14.46	10.28	76	102413	12964	34841478
Myasthenia gravis	14.42	10.28	49	102440	6891	34847551
Injection site pain	14.42	10.28	62	102427	38943	34815499
Ischaemic cerebral infarction	14.35	10.28	18	102471	1229	34853213
Hypophosphataemia	14.16	10.28	67	102422	10959	34843483
Diarrhoea	14.06	10.28	1326	101163	388586	34465856
Contraindicated product administered	13.98	10.28	26	102463	21455	34832987
Drug eruption	13.94	10.28	23	102466	19875	34834567
Blood chloride decreased	13.90	10.28	33	102456	3780	34850662
Pruritus	13.79	10.28	314	102175	141667	34712775
Sensory integrative dysfunction	13.64	10.28	5	102484	37	34854405
Type IIa hyperlipidaemia	13.57	10.28	8	102481	190	34854252
Shoshin beriberi	13.54	10.28	6	102483	76	34854366
Rhabdomyolysis	13.54	10.28	131	102358	68032	34786410
Atrial enlargement	13.50	10.28	13	102476	659	34853783
Cardiomyopathy	13.50	10.28	90	102399	16718	34837724
Nikolsky's sign	13.46	10.28	8	102481	193	34854249
Respiratory tract infection bacterial	13.44	10.28	21	102468	1761	34852681
Substance abuse	13.37	10.28	3	102486	7638	34846804
Multiple organ dysfunction syndrome	13.31	10.28	306	102183	76260	34778182
Emotional disorder of childhood	13.31	10.28	5	102484	40	34854402
Red blood cells urine positive	13.20	10.28	21	102468	1788	34852654
Oesophagitis	13.16	10.28	75	102414	13186	34841256
Cor pulmonale	13.13	10.28	14	102475	802	34853640
Urinary tract infection	13.09	10.28	331	102158	83750	34770692
Product preparation error	13.09	10.28	24	102465	2293	34852149
Renal tubular acidosis	13.07	10.28	24	102465	2295	34852147
Anaphylactic reaction	12.78	10.28	50	102439	32251	34822191
Dystonia	12.76	10.28	8	102481	10837	34843605
Atrial septal defect	12.74	10.28	3	102486	7389	34847053
Interstitial lung disease	12.74	10.28	126	102363	65156	34789286
Miosis	12.73	10.28	6	102483	9529	34844913
Drug ineffective for unapproved indication	12.70	10.28	32	102457	23683	34830759
Hyperphosphataemia	12.65	10.28	35	102454	4402	34850040
Pathogen resistance	12.60	10.28	6	102483	9476	34844966
Encephalitis	12.45	10.28	3	102486	7274	34847168
Femur fracture	12.42	10.28	52	102437	8072	34846370
Disturbance in attention	12.41	10.28	37	102452	25908	34828534
Endophthalmitis	12.40	10.28	30	102459	3478	34850964
Copper deficiency	12.40	10.28	4	102485	19	34854423
Blood glucose increased	12.34	10.28	269	102220	66449	34787993
Unevaluable event	12.32	10.28	148	102341	32442	34822000
Neuroleptic malignant syndrome	12.31	10.28	21	102468	17913	34836529
Pemphigoid	12.28	10.28	5	102484	8661	34845781
Asthma	12.24	10.28	74	102415	42582	34811860
Product prescribing error	12.23	10.28	31	102458	22896	34831546
Gastrointestinal vascular malformation haemorrhagic	12.19	10.28	12	102477	625	34853817
Deep vein thrombosis	12.04	10.28	263	102226	64985	34789457
Right ventricular dysfunction	12.01	10.28	16	102473	1160	34853282
Prothrombin time prolonged	11.97	10.28	57	102432	9349	34845093
Metabolic acidosis	11.91	10.28	77	102412	43603	34810839
Red blood cell sedimentation rate increased	11.87	10.28	6	102483	9156	34845286
Chest X-ray abnormal	11.86	10.28	34	102455	4364	34850078
Generalised tonic-clonic seizure	11.79	10.28	28	102461	21146	34833296
Cholestasis	11.79	10.28	40	102449	26908	34827534
Peripheral vascular disorder	11.76	10.28	37	102452	4999	34849443
Metabolic alkalosis	11.76	10.28	18	102471	1483	34852959
Respiratory failure	11.63	10.28	408	102081	108164	34746278
Face oedema	11.60	10.28	10	102479	11506	34842936
Pancytopenia	11.58	10.28	363	102126	94794	34759648
Anaphylactic shock	11.57	10.28	18	102471	15923	34838519
Agitation	11.53	10.28	110	102379	57289	34797153
Delusion	11.52	10.28	12	102477	12623	34841819
Hepatitis	11.50	10.28	34	102455	23870	34830572
Lymphocyte count decreased	11.48	10.28	109	102380	22513	34831929
Seizure	11.31	10.28	228	102261	104629	34749813
Lower respiratory tract infection	11.26	10.28	51	102438	31586	34822856
Bone marrow failure	11.13	10.28	133	102356	29120	34825322
Chronic left ventricular failure	11.13	10.28	11	102478	576	34853866
Full blood count abnormal	11.04	10.28	93	102396	18575	34835867
Oropharyngeal pain	11.02	10.28	60	102429	35425	34819017
Chronic respiratory failure	11.00	10.28	17	102472	1412	34853030
Thrombotic microangiopathy	10.99	10.28	9	102480	10621	34843821
Cardiac pacemaker evaluation	10.92	10.28	6	102483	124	34854318
Metastases to lung	10.80	10.28	55	102434	9265	34845177
Ileus	10.74	10.28	84	102405	16415	34838027
Lung consolidation	10.69	10.28	40	102449	5896	34848546
Dyskinesia	10.69	10.28	32	102457	22381	34832061
Catheterisation cardiac	10.68	10.28	24	102465	2653	34851789
Rash maculo-papular	10.65	10.28	45	102444	28406	34826036
Post transplant lymphoproliferative disorder	10.58	10.28	3	102486	6525	34847917
Cortical visual impairment	10.54	10.28	4	102485	33	34854409
Bacteraemia	10.51	10.28	96	102393	19621	34834821
Depressed level of consciousness	10.45	10.28	78	102411	42763	34811679
Tendonitis	10.40	10.28	7	102482	9133	34845309
Arrhythmia supraventricular	10.40	10.28	16	102473	1324	34853118
Drug chemical incompatibility	10.37	10.28	3	102486	9	34854433
Blood creatine phosphokinase increased	10.32	10.28	83	102406	44774	34809668
Radiation inflammation	10.31	10.28	13	102476	892	34853550

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	565.99	9.34	1368	220245	1079545	78443230
Cardiac failure congestive	305.17	9.34	980	220633	141422	79381353
Hypokalaemia	261.70	9.34	938	220675	143102	79379673
Prostatic specific antigen increased	255.78	9.34	220	221393	10166	79512609
Pemphigus	244.17	9.34	7	221606	99575	79423200
Hand deformity	238.80	9.34	12	221601	103907	79418868
Toxic anterior segment syndrome	234.20	9.34	126	221487	2638	79520137
Anti-cyclic citrullinated peptide antibody positive	207.01	9.34	5	221608	83138	79439637
Systemic lupus erythematosus	195.37	9.34	48	221565	121101	79401674
Drug abuse	191.19	9.34	107	221506	162584	79360191
Pericarditis	187.33	9.34	32	221581	104204	79418571
Atrial fibrillation	186.78	9.34	1061	220552	196825	79325950
Hypervolaemia	181.15	9.34	380	221233	42310	79480465
Contraindicated product administered	169.30	9.34	115	221498	157423	79365352
Joint swelling	167.38	9.34	344	221269	288302	79234473
Rheumatoid arthritis	163.78	9.34	203	221410	208267	79314508
Blood potassium decreased	160.26	9.34	381	221232	46131	79476644
Oedema peripheral	150.36	9.34	1207	220406	251081	79271694
Rheumatoid factor positive	147.45	9.34	4	221609	59835	79462940
Hypotension	145.53	9.34	1865	219748	438452	79084323
Duodenal ulcer perforation	144.95	9.34	10	221603	66201	79456574
Therapeutic product effect decreased	144.66	9.34	145	221468	163718	79359057
Sedation complication	142.45	9.34	196	221417	15473	79507302
Creatinine renal clearance decreased	141.13	9.34	216	221397	18786	79503989
Helicobacter infection	140.41	9.34	15	221598	69689	79453086
Wound	139.99	9.34	74	221539	116105	79406670
Hyperkalaemia	139.55	9.34	659	220954	113739	79409036
Pulmonary hypertension	138.57	9.34	368	221245	47712	79475063
Glossodynia	136.52	9.34	58	221555	103279	79419496
Blood calcium decreased	133.56	9.34	282	221331	31537	79491238
Pneumonia	133.05	9.34	2573	219040	657673	78865102
Maternal exposure during pregnancy	128.52	9.34	114	221499	136424	79386351
Anaemia	121.08	9.34	1821	219792	443194	79079581
Acute respiratory failure	120.44	9.34	402	221211	59139	79463636
Colitis microscopic	120.14	9.34	149	221464	10619	79512156
Cytokine release syndrome	117.71	9.34	289	221324	35709	79487066
Constipation	116.06	9.34	1250	220363	281800	79240975
Synovitis	113.99	9.34	151	221462	150583	79372192
Dehydration	112.14	9.34	1118	220495	247069	79275706
Musculoskeletal stiffness	110.61	9.34	198	221415	174810	79347965
Off label use	109.51	9.34	1819	219794	905396	78617379
Drug intolerance	109.48	9.34	372	221241	263747	79259028
Sleep disorder due to general medical condition, insomnia type	106.98	9.34	3	221610	43553	79479222
Dyspnoea	105.40	9.34	3120	218493	853905	78668870
Sepsis	105.00	9.34	1178	220435	268250	79254525
Intentional product use issue	104.54	9.34	163	221450	151949	79370826
Muscle injury	101.62	9.34	9	221604	48552	79474223
Arthralgia	100.94	9.34	1059	220554	570744	78952031
Fluid retention	100.85	9.34	423	221190	69386	79453389
Hypersensitivity	100.30	9.34	382	221231	261857	79260918
Right ventricular failure	98.33	9.34	208	221405	23289	79499486
Toxicity to various agents	97.60	9.34	728	220885	420812	79101963
Hypoxia	96.94	9.34	553	221060	102690	79420085
Discomfort	95.83	9.34	125	221488	125492	79397283
Alopecia	95.77	9.34	326	221287	231029	79291746
Hepatic enzyme increased	95.64	9.34	230	221383	182380	79340395
Pulmonary arterial hypertension	94.09	9.34	229	221384	28137	79494638
Folliculitis	93.13	9.34	20	221593	55360	79467415
Infusion related reaction	92.89	9.34	328	221285	229909	79292866
Arthropathy	92.81	9.34	223	221390	176888	79345887
Plasma cell myeloma	92.53	9.34	342	221271	52917	79469858
Treatment failure	92.27	9.34	211	221402	170275	79352500
Methaemoglobinaemia	89.43	9.34	93	221520	5464	79517311
Product use issue	85.92	9.34	297	221316	209525	79313250
Suicide attempt	85.82	9.34	63	221550	82869	79439906
Chronic obstructive pulmonary disease	83.14	9.34	462	221151	84957	79437818
Lower respiratory tract infection	82.71	9.34	145	221468	129075	79393700
Bronchitis	82.67	9.34	634	220979	130010	79392765
Orthostatic hypotension	81.65	9.34	341	221272	55823	79466952
Glaucoma	81.61	9.34	174	221439	19587	79503188
Asthenia	80.58	9.34	1925	219688	509764	79013011
Haemoglobin decreased	79.73	9.34	956	220657	221163	79301612
Abdominal discomfort	75.54	9.34	399	221214	250328	79272447
Gastrointestinal haemorrhage	74.88	9.34	682	220931	147037	79375738
Appendicolith	74.79	9.34	105	221508	8446	79514329
International normalised ratio increased	74.47	9.34	446	221167	84275	79438500
Ascites	73.08	9.34	408	221205	75154	79447621
Fall	71.22	9.34	1816	219797	485813	79036962
Product use in unapproved indication	67.02	9.34	414	221199	249945	79272830
Intentional self-injury	65.23	9.34	7	221606	32412	79490363
Impaired healing	65.04	9.34	89	221524	87566	79435209
Irritable bowel syndrome	64.77	9.34	47	221566	62194	79460581
Respiratory failure	63.74	9.34	776	220837	180135	79342640
Sopor	61.86	9.34	9	221604	33001	79489774
Rheumatic fever	60.47	9.34	5	221608	28520	79494255
Exposure during pregnancy	59.84	9.34	119	221494	101013	79421762
Platelet count decreased	59.32	9.34	813	220800	193851	79328924
Rash	59.07	9.34	1193	220420	577165	78945610
Cardiogenic shock	58.99	9.34	252	221361	41662	79481113
Intentional overdose	58.24	9.34	130	221483	105830	79416945
Psoriatic arthropathy	58.07	9.34	79	221534	77920	79444855
Mental status changes	57.89	9.34	351	221262	66608	79456167
Diarrhoea	55.51	9.34	2983	218630	877506	78645269
Urinary tract infection	55.43	9.34	1071	220542	273441	79249334
Ventricular fibrillation	54.60	9.34	204	221409	31722	79491053
Diverticulitis	53.36	9.34	261	221352	45675	79477100
Abdominal distension	53.00	9.34	537	221076	119113	79403662
Drug interaction	52.99	9.34	823	220790	414360	79108415
Deep vein thrombosis	52.28	9.34	540	221073	120379	79402396
Drug reaction with eosinophilia and systemic symptoms	52.06	9.34	61	221552	64183	79458592
Swollen joint count increased	51.56	9.34	3	221610	22924	79499851
Drug hypersensitivity	51.24	9.34	557	221056	298359	79224416
Atrial flutter	51.03	9.34	154	221459	21471	79501304
Balance disorder	50.88	9.34	458	221155	98399	79424376
Gastrooesophageal reflux disease	50.64	9.34	477	221136	103769	79419006
White blood cell count decreased	49.70	9.34	767	220846	187521	79335254
Blood urea increased	49.55	9.34	267	221346	48523	79474252
Psoriasis	49.16	9.34	110	221503	89477	79433298
Ill-defined disorder	48.75	9.34	67	221546	65808	79456967
Death	48.41	9.34	1979	219634	564535	78958240
Completed suicide	48.34	9.34	443	221170	245324	79277451
Hepatocellular injury	48.15	9.34	37	221576	47556	79475219
Therapeutic product effect incomplete	46.29	9.34	219	221394	141426	79381349
Dyspnoea exertional	45.63	9.34	405	221208	86668	79436107
Prostate cancer metastatic	45.59	9.34	56	221557	3951	79518824
Pleural effusion	45.19	9.34	609	221004	144653	79378122
Incision site pain	44.89	9.34	47	221566	2783	79519992
Drug eruption	44.65	9.34	34	221579	43901	79478874
Blood pressure fluctuation	44.19	9.34	74	221539	67071	79455704
Appendicitis	43.47	9.34	142	221471	20652	79502123
Urticaria	43.17	9.34	319	221294	184882	79337893
Oedema	43.00	9.34	515	221098	119065	79403710
Device expulsion	42.16	9.34	10	221603	25851	79496924
Cardiac failure	42.11	9.34	634	220979	154208	79368567
Spinal muscular atrophy	41.68	9.34	21	221592	382	79522393
Cognitive disorder	40.72	9.34	333	221280	69593	79453182
Pneumonia aspiration	40.68	9.34	322	221291	66645	79456130
Overdose	40.25	9.34	323	221290	183883	79338892
Nasopharyngitis	38.87	9.34	485	221128	253396	79269379
Blister	38.30	9.34	186	221427	119290	79403485
Blood phosphorus increased	38.08	9.34	87	221526	10260	79512515
Injection site pain	37.75	9.34	209	221404	129629	79393146
Cellulitis	37.61	9.34	466	221147	108594	79414181
Therapeutic response decreased	37.57	9.34	81	221532	66772	79456003
Cor pulmonale	36.58	9.34	38	221575	2230	79520545
Atelectasis	36.55	9.34	182	221431	32075	79490700
Multiple allergies	36.36	9.34	86	221527	10374	79512401
Swelling	36.24	9.34	406	221207	216305	79306470
Sedation	35.73	9.34	257	221356	51638	79471137
Multiple drug therapy	35.55	9.34	50	221563	4028	79518747
Endophthalmitis	35.54	9.34	64	221549	6364	79516411
Blood alkaline phosphatase increased	35.38	9.34	300	221313	63364	79459411
Cataract operation complication	35.04	9.34	17	221596	284	79522491
Pregnancy	33.99	9.34	16	221597	26835	79495940
Hepatitis	33.45	9.34	65	221548	55662	79467113
Suicidal ideation	33.33	9.34	105	221508	76235	79446540
Gastrointestinal disorder	33.23	9.34	201	221412	122004	79400771
Ventricular tachycardia	33.23	9.34	215	221398	41720	79481055
Inappropriate schedule of product administration	33.17	9.34	226	221387	133402	79389373
Macular degeneration	33.08	9.34	87	221526	11209	79511566
Transfusion	32.97	9.34	132	221481	21198	79501577
Pulmonary oedema	32.57	9.34	382	221231	87872	79434903
Full blood count decreased	32.31	9.34	154	221459	26665	79496110
Sputum increased	32.25	9.34	51	221562	4562	79518213
Thrombosis	31.92	9.34	366	221247	83734	79439041
Injection site swelling	31.89	9.34	51	221562	47081	79475694
Lymphoedema	31.77	9.34	91	221522	12322	79510453
Metastases to bone	31.44	9.34	143	221470	24284	79498491
Injection site reaction	31.10	9.34	66	221547	54719	79468056
Diaphragmatic spasm	31.04	9.34	12	221601	111	79522664
Cytomegalovirus infection	30.93	9.34	44	221569	42600	79480175
Chronic respiratory failure	30.84	9.34	40	221573	2982	79519793
Electrolyte imbalance	30.01	9.34	167	221446	30714	79492061
Cardiac arrest	29.95	9.34	657	220956	171439	79351336
Injection site erythema	29.79	9.34	114	221499	78083	79444692
Laboratory test abnormal	29.51	9.34	155	221458	27893	79494882
Grip strength decreased	29.31	9.34	12	221601	21857	79500918
Serotonin syndrome	29.28	9.34	50	221563	44977	79477798
Blood bilirubin increased	29.19	9.34	297	221316	65935	79456840
Chronic sinusitis	29.09	9.34	91	221522	12935	79509840
Product residue present	28.84	9.34	42	221571	3494	79519281
Cardiomegaly	28.67	9.34	147	221466	26205	79496570
Motor neurone disease	28.67	9.34	19	221594	589	79522186
Failure to thrive	28.56	9.34	85	221528	11759	79511016
Abortion spontaneous	28.52	9.34	24	221589	29483	79493292
Tachypnoea	28.29	9.34	169	221444	31894	79490881
Prothrombin time prolonged	28.08	9.34	107	221506	16792	79505983
Epilepsy	27.85	9.34	44	221569	40816	79481959
Metabolic alkalosis	27.82	9.34	47	221566	4442	79518333
Syncope	27.80	9.34	674	220939	178775	79344000
Emphysema	27.74	9.34	104	221509	16196	79506579
Loss of personal independence in daily activities	27.74	9.34	169	221444	102411	79420364
Angioedema	27.60	9.34	113	221500	75922	79446853
Blood glucose increased	27.56	9.34	461	221152	114514	79408261
Female genital tract fistula	27.48	9.34	55	221558	5920	79516855
Rhinocerebral mucormycosis	27.25	9.34	23	221590	1035	79521740
Drug ineffective for unapproved indication	27.23	9.34	64	221549	51174	79471601
Lung infiltration	27.19	9.34	131	221482	22781	79499994
Hip arthroplasty	26.83	9.34	36	221577	35720	79487055
Blood pressure diastolic abnormal	26.62	9.34	10	221603	19192	79503583
Clostridium difficile colitis	26.49	9.34	167	221446	32116	79490659
Dementia	26.44	9.34	137	221476	24522	79498253
Drug resistance	26.43	9.34	48	221565	42165	79480610
Blood magnesium decreased	26.17	9.34	103	221510	16409	79506366
Post procedural complication	25.98	9.34	133	221480	23696	79499079
Renal failure	25.97	9.34	737	220876	200231	79322544
Stoma closure	25.94	9.34	14	221599	295	79522480
Chest pain	25.86	9.34	994	220619	281310	79241465
Unevaluable event	25.83	9.34	252	221361	55333	79467442
Copper deficiency	25.71	9.34	11	221602	135	79522640
Tenosynovitis	25.38	9.34	6	221607	15548	79507227
Stomatitis	25.30	9.34	273	221340	146484	79376291
Aggression	25.24	9.34	66	221547	50892	79471883
Drug-induced liver injury	24.79	9.34	97	221516	66020	79456755
Haematocrit decreased	24.70	9.34	270	221343	61042	79461733
Vaginal flatulence	24.60	9.34	33	221580	2542	79520233
Joint range of motion decreased	24.47	9.34	34	221579	33248	79489527
Injection site bruising	24.46	9.34	48	221565	40954	79481821
Blood potassium increased	24.37	9.34	152	221461	29123	79493652
Polyneuropathy	24.14	9.34	19	221594	24132	79498643
Calcium deficiency	24.10	9.34	20	221593	879	79521896
Febrile neutropenia	23.99	9.34	825	220788	230174	79292601
Wrong technique in product usage process	23.67	9.34	115	221498	73760	79449015
Pneumococcal sepsis	23.55	9.34	26	221587	1636	79521139
Pulmonary fibrosis	23.52	9.34	55	221558	44057	79478718
Brain natriuretic peptide increased	23.52	9.34	66	221547	8834	79513941
Blood loss anaemia	23.23	9.34	95	221518	15403	79507372
Oxygen consumption increased	23.10	9.34	46	221567	4933	79517842
Pulmonary embolism	22.87	9.34	632	220981	171022	79351753
Pulmonary pain	22.80	9.34	43	221570	4430	79518345
Exercise tolerance decreased	22.74	9.34	66	221547	9005	79513770
Poisoning	22.70	9.34	22	221591	25250	79497525
Rheumatoid nodule	22.68	9.34	10	221603	17428	79505347
Thrombotic microangiopathy	22.63	9.34	14	221599	20155	79502620
Faecal volume decreased	22.61	9.34	11	221602	185	79522590
Right ventricular dysfunction	22.52	9.34	32	221581	2603	79520172
Depressed mood	22.36	9.34	65	221548	48415	79474360
Miosis	22.27	9.34	8	221605	15781	79506994
Blood pressure systolic abnormal	22.26	9.34	10	221603	17237	79505538
Cardiac disorder	22.24	9.34	280	221333	65477	79457298
Toxic epidermal necrolysis	22.14	9.34	205	221408	44376	79478399
Heparin-induced thrombocytopenia	21.96	9.34	68	221545	9614	79513161
Urine chloride decreased	21.83	9.34	9	221604	100	79522675
Pain in jaw	21.82	9.34	210	221403	45941	79476834
Interstitial lung disease	21.67	9.34	204	221409	112396	79410379
Red blood cell sedimentation rate increased	21.63	9.34	61	221552	45881	79476894
Blood pressure systolic increased	21.62	9.34	104	221509	66882	79455893
Electrocardiogram abnormal	21.55	9.34	98	221515	16639	79506136
Atrial enlargement	21.53	9.34	20	221593	1023	79521752
C-reactive protein abnormal	21.48	9.34	66	221547	48301	79474474
Product substitution issue	21.46	9.34	15	221598	20241	79502534
Disturbance in attention	21.39	9.34	71	221542	50730	79472045
Ankylosing spondylitis	21.37	9.34	4	221609	12201	79510574
Facet joint syndrome	21.37	9.34	3	221610	11299	79511476
Arthritis	21.32	9.34	210	221403	114670	79408105
Coagulopathy	21.25	9.34	172	221441	35834	79486941
Acute kidney injury	21.22	9.34	1697	219916	517707	79005068
Blood pressure diastolic increased	21.14	9.34	7	221606	14535	79508240
Hospice care	21.13	9.34	70	221543	10254	79512521
Generalised oedema	20.94	9.34	125	221488	23584	79499191
Catheter management	20.93	9.34	37	221576	3626	79519149
Adverse drug reaction	20.90	9.34	104	221509	66288	79456487
Cardiac failure acute	20.88	9.34	106	221507	18823	79503952
Electrocardiogram T wave amplitude decreased	20.76	9.34	17	221596	733	79522042
Neuroleptic malignant syndrome	20.42	9.34	28	221585	27531	79495244
Sleep apnoea syndrome	20.32	9.34	172	221441	36306	79486469
Immune effector cell-associated neurotoxicity syndrome	20.24	9.34	48	221565	5800	79516975
Posterior reversible encephalopathy syndrome	20.19	9.34	26	221587	26255	79496520
Accidental exposure to product	20.16	9.34	35	221578	31287	79491488
Malnutrition	20.11	9.34	119	221494	22383	79500392
Hiatus hernia	20.01	9.34	122	221491	23190	79499585
Liver injury	20.01	9.34	85	221528	56529	79466246
Hyponatraemia	19.95	9.34	641	220972	177207	79345568
Headache	19.85	9.34	1556	220057	652216	78870559
Inflammation	19.73	9.34	166	221447	93587	79429188
Peritonitis bacterial	19.70	9.34	65	221548	9502	79513273
Metabolic encephalopathy	19.60	9.34	63	221550	9084	79513691
Blood parathyroid hormone decreased	19.45	9.34	3	221610	10533	79512242
Pathological fracture	19.43	9.34	69	221544	10468	79512307
Hypomagnesaemia	19.09	9.34	207	221406	46704	79476071
Disability	19.05	9.34	12	221601	17108	79505667
Impaired work ability	19.03	9.34	16	221597	19665	79503110
Hypophagia	18.84	9.34	201	221412	45166	79477609
Resuscitation	18.81	9.34	28	221585	2376	79520399
Electrocardiogram T wave peaked	18.80	9.34	18	221595	957	79521818
Hypovolaemia	18.77	9.34	98	221515	17593	79505182
Small intestinal obstruction	18.74	9.34	135	221478	27137	79495638
Catheterisation cardiac	18.73	9.34	46	221567	5682	79517093
Hallucination, auditory	18.60	9.34	18	221595	20675	79502100
Oesophageal spasm	18.59	9.34	34	221579	3422	79519353
Thyroid disorder	18.55	9.34	83	221530	13996	79508779
Glomerular filtration rate	18.51	9.34	9	221604	151	79522624
Fibromyalgia	18.46	9.34	104	221509	64236	79458539
Live birth	18.42	9.34	15	221598	18729	79504046
Infection	18.39	9.34	521	221092	241191	79281584
Anhedonia	18.27	9.34	86	221527	14812	79507963
Hypophosphataemia	18.24	9.34	106	221507	19807	79502968
Hypernatraemia	18.15	9.34	84	221529	14367	79508408
Blood chloride decreased	18.15	9.34	57	221556	8120	79514655
Oesophageal pain	18.04	9.34	38	221575	4241	79518534
Chronic left ventricular failure	18.02	9.34	18	221595	1008	79521767
Alkalosis	18.01	9.34	14	221599	560	79522215
Gout	17.87	9.34	124	221489	24625	79498150
Scrotal oedema	17.79	9.34	22	221591	1563	79521212
Oesophagitis	17.72	9.34	122	221491	24167	79498608
Blood creatinine increased	17.69	9.34	560	221053	154497	79368278
Metastases to liver	17.66	9.34	137	221476	28177	79494598
Ileus	17.58	9.34	129	221484	26082	79496693
Radiculopathy	17.32	9.34	59	221554	8765	79514010
Blood albumin decreased	17.23	9.34	121	221492	24122	79498653
Respiratory distress	17.08	9.34	242	221371	58097	79464678
Blood immunoglobulin M increased	17.03	9.34	20	221593	1346	79521429
Arrhythmia supraventricular	16.96	9.34	25	221588	2102	79520673
Agranulocytosis	16.92	9.34	66	221547	44964	79477811
Bacteraemia	16.84	9.34	152	221461	32672	79490103
Pemphigoid	16.68	9.34	11	221602	15304	79507471
Psychotic disorder	16.66	9.34	59	221554	41343	79481432
Pulmonary arterial pressure increased	16.43	9.34	38	221575	4517	79518258
Pruritus	16.41	9.34	913	220700	393735	79129040
Nail dystrophy	16.39	9.34	17	221596	996	79521779
Peripheral circulatory failure	16.36	9.34	18	221595	1128	79521647
Mania	16.28	9.34	16	221597	18244	79504531
Paraesthesia oral	16.24	9.34	105	221508	20366	79502409
Panniculitis	16.24	9.34	7	221606	12364	79510411
Asthma	16.12	9.34	271	221342	134824	79387951
Anaphylactic shock	16.07	9.34	49	221564	35947	79486828
Urine sodium decreased	16.05	9.34	10	221603	278	79522497
Cholelithiasis	16.04	9.34	220	221393	52444	79470331
Pulse absent	16.00	9.34	63	221550	10040	79512735
Rash maculo-papular	15.90	9.34	91	221522	55987	79466788
Post transplant lymphoproliferative disorder	15.84	9.34	6	221607	11458	79511317
Multiple organ dysfunction syndrome	15.81	9.34	442	221171	119804	79402971
Haematotoxicity	15.78	9.34	12	221601	15507	79507268
Sleep disorder	15.73	9.34	157	221456	85520	79437255
Transient aphasia	15.70	9.34	12	221601	468	79522307
Catheter site infection	15.67	9.34	48	221565	6747	79516028
Lip dry	15.58	9.34	12	221601	15406	79507369
Metastases to spine	15.52	9.34	36	221577	4288	79518487
Hospitalisation	15.52	9.34	357	221256	93879	79428896
Disease complication	15.47	9.34	39	221574	4898	79517877
Substance abuse	15.42	9.34	5	221608	10521	79512254
Obstructive airways disorder	15.39	9.34	41	221572	31418	79491357
Acute left ventricular failure	15.36	9.34	22	221591	1802	79520973
Prescribed overdose	15.23	9.34	54	221559	37829	79484946
Metastases to soft tissue	15.20	9.34	13	221600	596	79522179
Multiple-drug resistance	15.18	9.34	3	221610	8805	79513970
Transplant rejection	15.17	9.34	19	221594	19418	79503357
Mitral valve incompetence	15.03	9.34	133	221480	28432	79494343
Hallucination, visual	15.01	9.34	44	221569	32685	79490090
Tendonitis	15.00	9.34	27	221586	23803	79498972
Extrapyramidal disorder	14.91	9.34	25	221588	22654	79500121
Blood potassium abnormal	14.75	9.34	29	221584	3081	79519694
Pneumonia staphylococcal	14.75	9.34	38	221575	4836	79517939
Gastric cancer	14.62	9.34	5	221608	10174	79512601
Procedural pain	14.57	9.34	112	221501	22972	79499803
Activated partial thromboplastin time prolonged	14.54	9.34	78	221535	14150	79508625
Foot deformity	14.52	9.34	28	221585	24046	79498729
Arteriovenous malformation	14.48	9.34	21	221592	1740	79521035
Blood immunoglobulin A decreased	14.46	9.34	19	221594	1434	79521341
Paraesthesia	14.46	9.34	376	221237	175947	79346828
Aspartate aminotransferase increased	14.35	9.34	495	221118	138146	79384629
Cerebrovascular accident	14.25	9.34	547	221066	154745	79368030
Condition aggravated	14.22	9.34	1199	220414	499925	79022850
Type IIa hyperlipidaemia	14.14	9.34	9	221604	260	79522515
Hydronephrosis	14.14	9.34	90	221523	17364	79505411
Diverticulum	14.11	9.34	80	221533	14816	79507959
Body height decreased	13.99	9.34	54	221559	8526	79514249
Hormone-refractory prostate cancer	13.95	9.34	11	221602	449	79522326
Erythema	13.92	9.34	494	221119	222796	79299979
Shoshin beriberi	13.85	9.34	6	221607	76	79522699
Hernia	13.84	9.34	88	221525	16971	79505804
Tricuspid valve incompetence	13.79	9.34	98	221515	19614	79503161
Cardiac pacemaker evaluation	13.76	9.34	7	221606	130	79522645
Colitis	13.76	9.34	283	221330	73024	79449751
Eosinophilia	13.72	9.34	72	221541	45273	79477502
Ischaemic cerebral infarction	13.71	9.34	25	221588	2510	79520265
Amyloid arthropathy	13.70	9.34	12	221601	568	79522207
Lung consolidation	13.53	9.34	55	221558	8892	79513883
Pharyngitis	13.51	9.34	26	221587	22349	79500426
Face oedema	13.51	9.34	37	221576	28099	79494676
Salpingo-oophorectomy unilateral	13.50	9.34	14	221599	820	79521955
Blood uric acid increased	13.49	9.34	73	221540	13287	79509488
Body temperature decreased	13.48	9.34	45	221568	32100	79490675
Night sweats	13.48	9.34	87	221526	52008	79470767
Depressed level of consciousness	13.48	9.34	358	221255	96294	79426481
Hyperlipidaemia	13.47	9.34	121	221492	25972	79496803
Right atrial pressure increased	13.47	9.34	9	221604	283	79522492
Neuroglycopenia	13.46	9.34	11	221602	473	79522302
Pathogen resistance	13.45	9.34	12	221601	14330	79508445
Disease progression	13.45	9.34	634	220979	183728	79339047
Oesophageal carcinoma	13.43	9.34	7	221606	11077	79511698
Increased bronchial secretion	13.40	9.34	29	221584	3298	79519477
Lymphadenectomy	13.37	9.34	17	221596	1242	79521533
Bone erosion	13.36	9.34	18	221595	17829	79504946
Vertigo	13.36	9.34	125	221488	68957	79453818
Peri-implantitis	13.29	9.34	8	221605	209	79522566
Cataract operation	13.26	9.34	38	221575	5147	79517628
Drug tolerance decreased	13.24	9.34	10	221603	12968	79509807
Gastric polyps	13.23	9.34	31	221582	3716	79519059
Ventricular extrasystoles	13.23	9.34	97	221516	19607	79503168
Respiratory tract infection bacterial	13.21	9.34	22	221591	2055	79520720
Throat tightness	13.18	9.34	37	221576	27870	79494905
Skin candida	13.13	9.34	22	221591	2065	79520710
Abdominal pain	13.11	9.34	1255	220358	388314	79134461
Skin reaction	13.11	9.34	83	221530	15985	79506790
Altered state of consciousness	13.03	9.34	70	221543	43752	79479023
Erythema multiforme	13.01	9.34	18	221595	17633	79505142
Pneumothorax spontaneous	12.93	9.34	18	221595	1436	79521339
Therapeutic response shortened	12.92	9.34	15	221598	15848	79506927
Dystonia	12.81	9.34	25	221588	21374	79501401
Cor pulmonale chronic	12.75	9.34	9	221604	310	79522465
Skin odour abnormal	12.72	9.34	22	221591	2119	79520656
Anterior chamber disorder	12.66	9.34	7	221606	155	79522620
Peripheral vascular disorder	12.65	9.34	50	221563	7980	79514795
Proctitis	12.62	9.34	43	221570	6389	79516386
Candida infection	12.62	9.34	162	221451	38052	79484723
Device related infection	12.45	9.34	148	221465	34146	79488629
Poor quality sleep	12.38	9.34	28	221585	22694	79500081
Lower gastrointestinal haemorrhage	12.36	9.34	82	221531	16043	79506732
Cardioactive drug level increased	12.36	9.34	30	221583	3679	79519096
Deposit eye	12.33	9.34	5	221608	53	79522722
Left ventricular failure	12.26	9.34	56	221557	9525	79513250
Epistaxis	12.26	9.34	401	221212	111114	79411661
Paranoia	12.25	9.34	22	221591	19410	79503365
Supraventricular tachycardia	12.22	9.34	101	221512	21169	79501606
Blood pressure diastolic decreased	12.20	9.34	43	221570	30173	79492602
Thrombocytopenia	12.19	9.34	875	220738	264384	79258391
Transplant evaluation	12.19	9.34	19	221594	1678	79521097
Cardiomyopathy	12.19	9.34	128	221485	28646	79494129
Familial periodic paralysis	12.15	9.34	7	221606	168	79522607
Acne	12.15	9.34	37	221576	27153	79495622
Pancytopenia	12.10	9.34	570	221043	165175	79357600
Heart rate variability increased	12.09	9.34	5	221608	56	79522719
Vasculitis	12.06	9.34	33	221580	25069	79497706
Injection site warmth	12.06	9.34	14	221599	14793	79507982
Cancer pain	12.04	9.34	37	221576	5208	79517567
Necrosis ischaemic	12.03	9.34	15	221598	1075	79521700
Apathy	12.00	9.34	11	221602	12966	79509809
Asphyxia	12.00	9.34	9	221604	11711	79511064
Pneumocystis jirovecii pneumonia	11.99	9.34	48	221565	32460	79490315
Blood cholesterol decreased	11.96	9.34	19	221594	1706	79521069
Chills	11.90	9.34	552	221061	159682	79363093
Skin necrosis	11.84	9.34	20	221593	18067	79504708
Hepatic function abnormal	11.80	9.34	138	221475	72969	79449806
Mental status changes postoperative	11.79	9.34	7	221606	178	79522597
Occult blood positive	11.78	9.34	44	221569	6839	79515936
Beta haemolytic streptococcal infection	11.75	9.34	21	221592	2076	79520699
International normalised ratio decreased	11.73	9.34	49	221564	8021	79514754
Pickwickian syndrome	11.70	9.34	10	221603	458	79522317
Decreased appetite	11.65	9.34	1104	220509	341314	79181461
Rectal haemorrhage	11.63	9.34	286	221327	76014	79446761
Rhabdomyolysis	11.62	9.34	209	221404	102922	79419853
Psychomotor hyperactivity	11.62	9.34	18	221595	16831	79505944
Encephalopathy	11.62	9.34	257	221356	67140	79455635
Product preparation error	11.61	9.34	39	221574	5754	79517021
Drug chemical incompatibility	11.58	9.34	6	221607	116	79522659
Cortical visual impairment	11.57	9.34	4	221609	26	79522749
Dyskinesia	11.47	9.34	75	221538	44698	79478077
Skin laceration	11.42	9.34	127	221486	28835	79493940
Ischaemic cardiomyopathy	11.40	9.34	47	221566	7648	79515127
Urine albumin/creatinine ratio	11.39	9.34	3	221610	6	79522769
Hepatitis cholestatic	11.38	9.34	13	221600	13839	79508936
N-terminal prohormone brain natriuretic peptide increased	11.35	9.34	34	221579	4721	79518054
Myasthenia gravis	11.31	9.34	58	221555	10341	79512434
Poisoning deliberate	11.27	9.34	22	221591	18806	79503969
Coeliac disease	11.26	9.34	9	221604	11342	79511433
Injection site pruritus	11.25	9.34	70	221543	42213	79480562
Mood swings	11.24	9.34	24	221589	19856	79502919
Drug use disorder	11.19	9.34	5	221608	8646	79514129
COVID-19 pneumonia	11.14	9.34	126	221487	28723	79494052
Pneumonia streptococcal	11.14	9.34	24	221589	2721	79520054
Osteoarthritis	11.13	9.34	173	221440	87136	79435639
Red blood cell count decreased	11.11	9.34	223	221390	57290	79465485
Sinusitis fungal	11.09	9.34	22	221591	2352	79520423
Bronchiectasis	11.08	9.34	29	221584	22357	79500418
Leukocytosis	11.06	9.34	176	221437	43279	79479496
Cardiac amyloidosis	11.05	9.34	19	221594	1821	79520954
Electrocardiogram U wave present	11.01	9.34	6	221607	129	79522646
Diuretic therapy	11.01	9.34	7	221606	202	79522573
Tonsillar haemorrhage	10.97	9.34	8	221605	290	79522485
Inability to afford medication	10.97	9.34	24	221589	2749	79520026
Iatrogenic infection	10.97	9.34	5	221608	72	79522703
Vascular device infection	10.95	9.34	57	221556	10219	79512556
Basal cell carcinoma	10.95	9.34	60	221553	37315	79485460
Blood pressure increased	10.91	9.34	478	221135	210882	79311893
Radiation inflammation	10.87	9.34	13	221600	892	79521883
Movement disorder	10.86	9.34	39	221574	27220	79495555
Diastolic dysfunction	10.86	9.34	59	221554	10752	79512023
Blood immunoglobulin G increased	10.85	9.34	25	221588	2964	79519811
Skin dystrophy	10.85	9.34	5	221608	74	79522701
Sexual dysfunction	10.83	9.34	4	221609	7759	79515016
Nausea	10.82	9.34	2902	218711	954294	78568481
Bursitis	10.80	9.34	57	221556	35787	79486988
Acute hepatic failure	10.77	9.34	45	221568	30068	79492707
Gastritis erosive	10.77	9.34	59	221554	10788	79511987
Conjunctival scar	10.77	9.34	7	221606	210	79522565
Renal tubular acidosis	10.75	9.34	28	221585	3586	79519189
Euphoric mood	10.75	9.34	4	221609	7722	79515053
Hypersensitivity vasculitis	10.71	9.34	3	221610	6940	79515835
Pulmonary arterial wedge pressure increased	10.71	9.34	10	221603	515	79522260
Electrocardiogram ST segment abnormal	10.69	9.34	17	221596	1528	79521247
Anaphylactic reaction	10.65	9.34	166	221447	83577	79439198
Adjustment disorder with depressed mood	10.63	9.34	6	221607	9080	79513695
Confusion postoperative	10.62	9.34	7	221606	215	79522560
Lipoedema	10.62	9.34	7	221606	215	79522560
Supraventricular extrasystoles	10.61	9.34	43	221570	6944	79515831
Acquired diaphragmatic eventration	10.57	9.34	11	221602	647	79522128
Product storage error	10.56	9.34	18	221595	16208	79506567
Hypercapnia	10.54	9.34	51	221562	8884	79513891
Head injury	10.53	9.34	154	221459	37215	79485560
Abortion incomplete complicated	10.53	9.34	3	221610	9	79522766
Sinus disorder	10.51	9.34	102	221511	22362	79500413
Red blood cells urine positive	10.47	9.34	34	221579	4929	79517846
Intestinal polyp	10.44	9.34	20	221593	2084	79520691
Immune-mediated lung disease	10.44	9.34	21	221592	2269	79520506
Right ventricular dilatation	10.42	9.34	19	221594	1907	79520868
Mixed liver injury	10.42	9.34	4	221609	7574	79515201
Lower respiratory tract infection bacterial	10.30	9.34	13	221600	943	79521832
Hyperphosphataemia	10.29	9.34	40	221573	6336	79516439
Spinal cord compression	10.29	9.34	40	221573	6337	79516438
Catheter site scab	10.26	9.34	7	221606	228	79522547
Infusion site haemorrhage	10.24	9.34	28	221585	3692	79519083
Confusional state	10.22	9.34	753	220860	317244	79205531
Troponin T increased	10.19	9.34	27	221586	3495	79519280
Finger deformity	10.18	9.34	4	221609	7470	79515305
Blood sodium decreased	10.16	9.34	139	221474	33116	79489659
Aspiration pleural cavity	10.11	9.34	17	221596	1600	79521175
Renal injury	10.06	9.34	81	221532	16846	79505929
Arrhythmia	10.05	9.34	232	221381	61040	79461735
Aortic aneurysm rupture	10.01	9.34	15	221598	1280	79521495
Hypertransaminasaemia	10.01	9.34	11	221602	11913	79510862
Stress	10.01	9.34	291	221322	79321	79443454
Blood cholesterol increased	9.97	9.34	168	221445	83552	79439223
Blood albumin abnormal	9.95	9.34	11	221602	693	79522082
Therapeutic product effect prolonged	9.88	9.34	10	221603	569	79522206
Drug level increased	9.86	9.34	67	221546	39584	79483191
Hyperaldosteronism	9.84	9.34	9	221604	451	79522324
Knee arthroplasty	9.83	9.34	75	221538	43173	79479602
Clostridium difficile infection	9.80	9.34	170	221443	42515	79480260
Cardiac pacemaker insertion	9.79	9.34	37	221576	5785	79516990
Oxygen therapy	9.76	9.34	23	221590	2767	79520008
Mitral valve disease	9.75	9.34	25	221588	3172	79519603
Analgesic therapy	9.75	9.34	13	221600	996	79521779
Premature delivery	9.74	9.34	33	221580	23434	79499341
Potassium wasting nephropathy	9.72	9.34	6	221607	164	79522611
Cervix carcinoma recurrent	9.68	9.34	3	221610	13	79522762
Pupillary block	9.66	9.34	4	221609	45	79522730
Immune thrombocytopenia	9.65	9.34	22	221591	17783	79504992
Infrapatellar fat pad inflammation	9.63	9.34	6	221607	167	79522608
Hypoalbuminaemia	9.62	9.34	96	221517	21201	79501574
Thyroxine decreased	9.61	9.34	12	221601	861	79521914
Paracentesis	9.58	9.34	15	221598	1330	79521445
Blood aldosterone abnormal	9.58	9.34	4	221609	46	79522729
Generalised tonic-clonic seizure	9.58	9.34	77	221536	43833	79478942
Oropharyngeal pain	9.55	9.34	231	221382	109122	79413653
Paradoxical drug reaction	9.54	9.34	4	221609	7181	79515594
Device difficult to use	9.52	9.34	14	221599	13371	79509404
Nasal flaring	9.50	9.34	3	221610	14	79522761
Pulmonary tuberculosis	9.48	9.34	5	221608	7860	79514915
Adenocarcinoma	9.48	9.34	28	221585	3858	79518917
Labelled drug-drug interaction medication error	9.47	9.34	42	221571	27608	79495167
Drug therapy	9.41	9.34	14	221599	1187	79521588
Arteriosclerosis coronary artery	9.40	9.34	83	221530	17733	79505042

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Radiolabelling of carrier molecules	indication
Pregnancy, function	contraindication	289908002

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
CL	PDB_CHEM_ID
CLO	PDB_CHEM_ID
DB00761	DRUGBANK_ID
DB01164	DRUGBANK_ID
DB08913	DRUGBANK_ID
DB09129	DRUGBANK_ID
DB09316	DRUGBANK_ID
DB09498	DRUGBANK_ID
DB11056	DRUGBANK_ID
DB13569	DRUGBANK_ID
DB13987	DRUGBANK_ID
DB14206	DRUGBANK_ID
DB14533	DRUGBANK_ID
DB14547	DRUGBANK_ID
DB14550	DRUGBANK_ID
2351	INN_ID
D10828	KEGG_DRUG
71587001	PUBCHEM_CID
04M8624OXV	UNII
0EA6JO8O41	UNII
0S9308207L	UNII
0VK51DA1T2	UNII
11521XLD38	UNII
15443PR153	UNII
1JB99PM4G8	UNII
1SW3X68G1K	UNII
1U477369SN	UNII
20278OEG45	UNII
24Q3L637MM	UNII
25O44EQD4O	UNII
2I17MGM5YJ	UNII
2VU35LR5T9	UNII
2VY5D2E2HC	UNII
302HXL12MT	UNII
31JB8MKF8Z	UNII
37CB58V15B	UNII
3I8Y076A0E	UNII
3IGV2Y2378	UNII
3X55YB10CW	UNII
4X6566U3SD	UNII
4Y6GQD4915	UNII
53GH7MZT1R	UNII
53PH22NTYW	UNII
55X405F87A	UNII
58TD96H03I	UNII
5J4QGH7J16	UNII
5R78837D4A	UNII
6417YBA168	UNII
660YQ98I10	UNII
67H76LFL3V	UNII
696BNE976J	UNII
6TY2GU9Q9H	UNII
6YB4901Y90	UNII
73TYF012WF	UNII
779I95MPQK	UNII
7812FUQ8VK	UNII
804HI855F8	UNII
867J5QOF46	UNII
86Q357L16B	UNII
896SQ4TDHW	UNII
8E7IB152RL	UNII
8O3PJE5T7Q	UNII
950AA6B72O	UNII
99U3Q94QT1	UNII
9B6QP3540H	UNII
9D9PY7688B	UNII
9S1BC7865F	UNII
9WXV40ZI4M	UNII
A04B19O2B0	UNII
A71VE6C11B	UNII
B74O00UCWC	UNII
BB0UFP2VO5	UNII
BK26WI342Q	UNII
BQC3E45EYF	UNII
C0LI0UBL38	UNII
C955P95064	UNII
CAR334HOLD	UNII
CET32HKA21	UNII
CNZ9V5JM5H	UNII
E9Q0RQR3BZ	UNII
EKE8PS9J6Z	UNII
ETD2S9X9E7	UNII
EVS87XF13W	UNII
F0Z746KRKQ	UNII
FAE9RL3AWX	UNII
G46PX623OB	UNII
GHS5TFJ9TN	UNII
GNR9HML8BA	UNII
GVD566MM7K	UNII
IO29D13DLW	UNII
J281401KK3	UNII
J2D46N657D	UNII
J6K4F9V3BA	UNII
JD7Y972WU9	UNII
K8863V3I0P	UNII
KKO873WR2Z	UNII
L32HZV95ZE	UNII
LP6WL6W368	UNII
MWB0804EO7	UNII
N14HH19145	UNII
N3SHC5273S	UNII
N9214IR8N7	UNII
OFM21057LP	UNII
OY41894L96	UNII
P484053J2Y	UNII
P7082WY76D	UNII
PE8HIA0TMZ	UNII
Q2A03W637H	UNII
Q32ZN48698	UNII
Q4D88MX3Z8	UNII
Q65224GJ7F	UNII
Q82C221W4H	UNII
QTT17582CB	UNII
QU8E5FKO20	UNII
QVC0N62WQE	UNII
RJ00KV3VTG	UNII
RY8V1UJV23	UNII
S3Y25PHP1W	UNII
TH8E3IE00V	UNII
TIW7SL1DSX	UNII
TN98A27Q17	UNII
U38V3ZVV3V	UNII
U4M5Y13FGM	UNII
VSM6H46OKE	UNII
W3YUG71TU2	UNII
W7R4O3060V	UNII
Z310X5O5RP	UNII
ZL40NE83QQ	UNII
ZNL6IP5PJX	UNII
ZVL325FU75	UNII

Pharmaceutical products:

None