coumafos 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
insecticides, anthelminthics, pesticides etc., phosphorous derivatives 5667 56-72-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • coumafos
  • coumaphos
  • meldane
  • NSC-8944
  • BAYER-21199
A organothiophosphorus cholinesterase inhibitor that is used as an anthelmintic, insecticide, and as nematocide
  • Molecular weight: 362.76
  • Formula: C14H16ClO5PS
  • CLOGP: 4.53
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 0
  • TPSA: 53.99
  • ALOGS: -5.39
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:22153 acaricides
CHEBI has role CHEBI:33286 agricultural chemicals
CHEBI has role CHEBI:33289 avicides
CHEBI has role CHEBI:35444 antinematodal drugs
CHEBI has role CHEBI:37733 EC 3.1.1.8 inhibitor
MeSH PA D000871 Anthelmintics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000969 Antinematodal Agents
MeSH PA D000977 Antiparasitic Agents
MeSH PA D018678 Cholinergic Agents
MeSH PA D002800 Cholinesterase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D007306 Insecticides
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D010575 Pesticides

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

SpeciesUseRelation
Chickens Control of capillary worms (Capillaria obsignata) Indication
Chickens Control of common round worm, Ascaridia galli Indication
Chickens Control of cecal worm (Heterakis gallinae) Indication

🐶 Veterinary products

ProductApplicantIngredients
Meldane 2 Elanco US Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 1 Enzyme Ki 4.21 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 5.26 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 5.19 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 5.02 CHEMBL
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 5.29 CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme Ki 5.47 CHEMBL
Carbonic anhydrase 7 Enzyme Ki 5.33 CHEMBL
Carbonic anhydrase 3 Enzyme Ki 5.33 CHEMBL
Carbonic anhydrase 6 Enzyme Ki 5.65 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 5.38 CHEMBL
Carbonic anhydrase 13 Enzyme Ki 5.37 CHEMBL

External reference:

IDSource
CHEBI:3903 CHEBI
CHEMBL251680 ChEMBL_ID
DB11390 DRUGBANK_ID
C0010203 UMLSCUI
96128001 SNOMEDCT_US
1705 INN_ID
D07750 KEGG_DRUG
2871 PUBCHEM_CID
D003372 MESH_DESCRIPTOR_UI
L08SZ5Z5JC UNII

Pharmaceutical products:

None