cloprostenol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| prostaglandins | 5665 | 40665-92-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A synthetic prostaglandin F2alpha analog. The compound has luteolytic effects and is used for the synchronization of estrus in cattle
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D003270 | Contraceptive Agents |
| MeSH PA | D003271 | Contraceptive Agents, Female |
| MeSH PA | D000080066 | Contraceptive Agents, Hormonal |
| MeSH PA | D008186 | Luteolytic Agents |
| MeSH PA | D012102 | Reproductive Control Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cattle | Induction of luteolysis | Indication |
| Cattle | Estrus and ovulation programming interruption of unwanted pregnancies caused by incorrect pairings | Indication |
| Cattle | Treatment of unobserved estrus (undetected) | Indication |
| Cattle | Treatment of mummified fetus | Indication |
| Cattle | Treatment of luteal cysts | Indication |
| Cattle | Pyometra treatment | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Estrumate, Heifex | Intervet Inc. | 1 |
| estroPLAN Injection | Parnell Technologies Pty. Ltd. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP1 subtype | GPCR | IC50 | 6.30 | CHEMBL | |||||
| Prostaglandin E2 receptor EP3 subtype | GPCR | AGONIST | Ki | 8.36 | IUPHAR | ||||
| Prostaglandin E2 receptor EP2 subtype | GPCR | IC50 | 5.43 | CHEMBL | |||||
| Prostaglandin F2-alpha receptor | GPCR | IC50 | 9 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| CHEMBL2220404 | ChEMBL_ID |
| CHEMBL37853 | ChEMBL_ID |
| 1894 | IUPHAR_LIGAND_ID |
| DB11507 | DRUGBANK_ID |
| D003008 | MESH_DESCRIPTOR_UI |
| C0009030 | UMLSCUI |
| CHEMBL2218867 | ChEMBL_ID |
| CHEMBL1520583 | ChEMBL_ID |
| 3793 | INN_ID |
| 763009004 | SNOMEDCT_US |
| 96352000 | SNOMEDCT_US |
| 55028-72-3 | SECONDARY_CAS_RN |
| D07730 | KEGG_DRUG |
| 5311053 | PUBCHEM_CID |
| 204179 | RXNORM |
| 4208238832 | UNII |
Pharmaceutical products:
None