ceftriaxone ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, cefalosporanic acid derivatives 564 73384-59-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ceftriaxone sodium hydrate
  • ceftriaxone
  • biotrakson
  • rocefin
  • rocephalin
  • rophex
  • ceftriaxone sodium
A broad-spectrum cephalosporin antibiotic and cefotaxime derivative with a very long half-life and high penetrability to meninges, eyes and inner ears.
  • Molecular weight: 554.57
  • Formula: C18H18N8O7S3
  • CLOGP: -1.24
  • LIPINSKI: 2
  • HAC: 15
  • HDO: 4
  • TPSA: 208.98
  • ALOGS: -3.72
  • ROTB: 8

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2 g P
2 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 400 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 46 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 120.27 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 0 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.12 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.22 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.10 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 21, 1984 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 736.10 12.38 403 47480 33433 63407706
Acute generalised exanthematous pustulosis 405.71 12.38 188 47695 10911 63430228
Toxic epidermal necrolysis 389.50 12.38 241 47642 25093 63416046
Acute kidney injury 356.58 12.38 679 47204 262736 63178403
Eosinophilia 338.50 12.38 212 47671 22544 63418595
Pseudocholelithiasis 328.64 12.38 54 47829 6 63441133
Rash maculo-papular 291.37 12.38 220 47663 31676 63409463
Fatigue 244.07 12.38 189 47694 887839 62553300
Multiple organ dysfunction syndrome 238.02 12.38 252 47631 56500 63384639
Pain 214.45 12.38 149 47734 740479 62700660
Jarisch-Herxheimer reaction 208.79 12.38 50 47833 327 63440812
Off label use 206.08 12.38 1027 46856 673435 62767704
Joint swelling 205.64 12.38 10 47873 327656 63113483
Premature delivery 184.34 12.38 165 47718 30116 63411023
Septic shock 182.77 12.38 238 47645 66391 63374748
Agranulocytosis 181.49 12.38 151 47732 24983 63416156
Clostridium difficile colitis 179.28 12.38 138 47745 20431 63420708
Stevens-Johnson syndrome 176.23 12.38 148 47735 24802 63416337
Alopecia 167.53 12.38 27 47856 337509 63103630
Cholestasis 166.66 12.38 154 47729 29280 63411859
Cholelithiasis 163.13 12.38 183 47700 43742 63397397
Drug interaction 159.14 12.38 455 47428 228676 63212463
Rheumatoid arthritis 158.38 12.38 8 47875 253811 63187328
Arthropathy 158.23 12.38 4 47879 234788 63206351
Arthralgia 157.62 12.38 120 47763 569590 62871549
Drug intolerance 154.72 12.38 24 47859 308637 63132502
Electrocardiogram QT prolonged 153.01 12.38 206 47677 59324 63381815
Pyrexia 152.21 12.38 729 47154 469749 62971390
Recalled product administered 145.03 12.38 40 47843 485 63440654
Haemolytic anaemia 144.69 12.38 92 47791 10033 63431106
Hepatitis 139.66 12.38 161 47722 39627 63401512
Clostridium test positive 138.45 12.38 61 47822 3140 63437999
Abdominal discomfort 135.96 12.38 37 47846 320848 63120291
Status epilepticus 134.49 12.38 103 47780 15130 63426009
Factor V inhibition 127.36 12.38 29 47854 147 63440992
Anaphylactic shock 126.77 12.38 120 47763 23513 63417626
Tubulointerstitial nephritis 126.19 12.38 111 47772 19792 63421347
Therapeutic product effect decreased 120.77 12.38 6 47877 193181 63247958
Glossodynia 120.67 12.38 3 47880 178873 63262266
Pemphigus 120.57 12.38 4 47879 183722 63257417
Swelling 119.97 12.38 30 47853 275348 63165791
Headache 118.99 12.38 184 47699 633057 62808082
Contraindicated product administered 113.49 12.38 15 47868 217633 63223506
Hepatocellular injury 110.17 12.38 119 47764 27262 63413877
Systemic lupus erythematosus 109.89 12.38 14 47869 208904 63232235
Leukocytosis 106.60 12.38 114 47769 25821 63415318
Pulmonary function test abnormal 106.28 12.38 43 47840 1787 63439352
Blood lactic acid increased 105.28 12.38 66 47817 7020 63434119
Weight increased 103.29 12.38 34 47849 260758 63180381
Encephalopathy 102.82 12.38 136 47747 38484 63402655
Exposure during pregnancy 100.29 12.38 301 47582 155246 63285893
Drug ineffective for unapproved indication 96.99 12.38 124 47759 33939 63407200
Clostridium difficile infection 96.56 12.38 116 47767 29806 63411333
Wound 96.20 12.38 7 47876 163256 63277883
Chest X-ray abnormal 95.54 12.38 53 47830 4496 63436643
Peripheral swelling 94.75 12.38 41 47842 265901 63175238
Nasopharyngitis 94.13 12.38 37 47846 254220 63186919
Postrenal failure 93.71 12.38 23 47860 169 63440970
Respiratory failure 92.77 12.38 224 47659 101634 63339505
Product dose omission issue 91.98 12.38 31 47852 234282 63206857
Acute respiratory distress syndrome 90.70 12.38 100 47783 23434 63417705
Fall 90.01 12.38 98 47785 392236 63048903
Hepatitis cholestatic 87.24 12.38 58 47825 6820 63434319
Thrombocytopenia 86.80 12.38 281 47602 150876 63290263
Pericarditis 85.84 12.38 3 47880 131576 63309563
Ear pruritus 85.48 12.38 47 47836 3918 63437221
Cardiac arrest 84.78 12.38 204 47679 92341 63348798
Drug-induced liver injury 83.85 12.38 126 47757 40096 63401043
Sepsis 82.86 12.38 279 47604 152844 63288295
Altered state of consciousness 81.72 12.38 98 47785 25132 63416007
Pseudomembranous colitis 81.51 12.38 42 47841 3070 63438069
Transaminases increased 79.73 12.38 108 47775 31259 63409880
Enterococcal infection 75.79 12.38 56 47827 7792 63433347
Pain in extremity 73.59 12.38 85 47798 331401 63109738
Musculoskeletal stiffness 73.18 12.38 24 47859 184594 63256545
Discomfort 71.37 12.38 19 47864 167355 63273784
Neutropenia 71.32 12.38 291 47592 174714 63266425
Anaphylactic reaction 69.66 12.38 154 47729 65946 63375193
Haemophagocytic lymphohistiocytosis 68.83 12.38 60 47823 10567 63430572
Toxic encephalopathy 68.19 12.38 49 47834 6530 63434609
Pleocytosis 67.38 12.38 25 47858 820 63440319
Linear IgA disease 67.14 12.38 29 47854 1422 63439717
Dizziness 67.02 12.38 140 47743 429785 63011354
Contusion 65.96 12.38 16 47867 150028 63291111
Long QT syndrome 65.59 12.38 37 47846 3242 63437897
Injection site pain 65.16 12.38 10 47873 129790 63311349
Insomnia 65.07 12.38 41 47842 215211 63225928
Bronchopulmonary aspergillosis 64.65 12.38 53 47830 8582 63432557
Tachypnoea 62.36 12.38 71 47812 17231 63423908
Dermatitis exfoliative 62.01 12.38 43 47840 5416 63435723
Pneumococcal infection 61.65 12.38 20 47863 435 63440704
Acinetobacter infection 61.54 12.38 28 47855 1555 63439584
Alveolitis 61.32 12.38 34 47849 2881 63438258
Erythema 60.68 12.38 278 47605 175473 63265666
Metabolic acidosis 60.45 12.38 116 47767 44953 63396186
Hypoxia 60.42 12.38 137 47746 59655 63381484
Low birth weight baby 60.30 12.38 47 47836 7082 63434057
Choreoathetosis 58.70 12.38 20 47863 509 63440630
Cholecystitis 58.66 12.38 65 47818 15312 63425827
Nasal polyps 58.11 12.38 43 47840 5996 63435143
Urticaria 57.78 12.38 263 47620 165539 63275600
Helicobacter infection 57.58 12.38 3 47880 92782 63348357
Tachycardia 56.72 12.38 207 47676 117949 63323190
Psoriatic arthropathy 56.66 12.38 3 47880 91517 63349622
Torsade de pointes 53.65 12.38 58 47825 13293 63427846
No adverse event 52.41 12.38 104 47779 41301 63399838
Myasthenia gravis crisis 51.54 12.38 18 47865 494 63440645
Weight decreased 51.25 12.38 81 47802 276717 63164422
Platelet count increased 51.24 12.38 65 47818 17646 63423493
Infusion related reaction 51.23 12.38 66 47817 245455 63195684
Muscle spasms 51.09 12.38 27 47856 156123 63285016
Gait disturbance 49.93 12.38 39 47844 183139 63258000
Vasculitis 49.81 12.38 65 47818 18144 63422995
Influenza B virus test positive 49.54 12.38 15 47868 258 63440881
Pathogen resistance 49.44 12.38 40 47843 6358 63434781
Encephalitis 49.35 12.38 46 47837 8834 63432305
Mobility decreased 49.33 12.38 15 47868 121144 63319995
Dermatitis bullous 49.08 12.38 45 47838 8463 63432676
Renal failure 48.98 12.38 197 47686 117455 63323684
Sinusitis 48.25 12.38 60 47823 226593 63214546
Breath sounds abnormal 48.23 12.38 50 47833 10923 63430216
Symmetrical drug-related intertriginous and flexural exanthema 47.99 12.38 17 47866 487 63440652
Psoriasis 47.75 12.38 5 47878 86952 63354187
Hydronephrosis 47.61 12.38 49 47834 10613 63430526
Product use issue 47.34 12.38 58 47825 220462 63220677
Rash morbilliform 46.97 12.38 30 47853 3295 63437844
Shock 46.77 12.38 72 47811 23391 63417748
Acute respiratory failure 46.54 12.38 89 47794 34396 63406743
Nausea 46.03 12.38 418 47465 854053 62587086
Cholangitis 45.60 12.38 36 47847 5525 63435614
Gastrointestinal disorder 45.49 12.38 21 47862 131218 63309921
Rhinitis allergic 45.47 12.38 50 47833 11677 63429462
Depression 45.07 12.38 49 47834 196443 63244696
Premature baby 44.70 12.38 66 47817 20669 63420470
Lower respiratory tract infection 44.59 12.38 22 47861 132285 63308854
SJS-TEN overlap 44.16 12.38 15 47868 378 63440761
CSF oligoclonal band present 43.90 12.38 15 47868 385 63440754
Stenotrophomonas infection 43.62 12.38 24 47859 2003 63439136
Malaise 43.57 12.38 164 47719 415790 63025349
Pancytopenia 43.33 12.38 166 47717 96767 63344372
Cross sensitivity reaction 42.18 12.38 24 47859 2138 63439001
Ill-defined disorder 41.71 12.38 6 47877 81749 63359390
Migraine 41.70 12.38 13 47870 103333 63337806
Neutrophilia 41.56 12.38 31 47852 4375 63436764
Folliculitis 41.44 12.38 3 47880 70314 63370825
Stress cardiomyopathy 41.42 12.38 43 47840 9407 63431732
Stomatitis 41.12 12.38 27 47856 138698 63302441
Leukopenia 41.03 12.38 140 47743 77150 63363989
Hepatic cytolysis 40.60 12.38 54 47829 15353 63425786
Osteoarthritis 40.29 12.38 11 47872 95332 63345807
Treatment failure 39.99 12.38 55 47828 198988 63242151
Pyuria 39.38 12.38 22 47861 1892 63439247
Pyelonephritis 38.92 12.38 57 47826 17721 63423418
Nosocomial infection 38.76 12.38 21 47862 1700 63439439
Drug resistance 38.37 12.38 65 47818 22868 63418271
Injection site erythema 38.29 12.38 8 47875 83166 63357973
Rash erythematous 38.14 12.38 93 47790 42417 63398722
Guillain-Barre syndrome 38.09 12.38 28 47855 3865 63437274
Maternal exposure during pregnancy 37.97 12.38 290 47593 219772 63221367
Arthritis 37.97 12.38 20 47863 115901 63325238
Hypokalaemia 37.89 12.38 167 47716 103637 63337502
Abdominal pain upper 37.63 12.38 61 47822 206383 63234756
Haemolysis 37.50 12.38 35 47848 6733 63434406
Haemodynamic instability 37.06 12.38 40 47843 9150 63431989
Propofol infusion syndrome 37.00 12.38 17 47866 966 63440173
International normalised ratio increased 36.90 12.38 97 47786 46328 63394811
Fibromyalgia 36.48 12.38 8 47875 80412 63360727
Upper-airway cough syndrome 36.39 12.38 44 47839 11374 63429765
Myopathy toxic 36.19 12.38 14 47869 516 63440623
Hypertension 35.53 12.38 101 47782 279202 63161937
Hepatic enzyme increased 34.84 12.38 62 47821 202266 63238873
Immune reconstitution inflammatory syndrome 34.75 12.38 32 47851 6052 63435087
Impaired healing 34.62 12.38 17 47866 102525 63338614
Respiratory distress 34.52 12.38 78 47805 33873 63407266
Klebsiella infection 34.04 12.38 37 47846 8529 63432610
Angioedema 33.91 12.38 96 47787 47869 63393270
Partial seizures 33.90 12.38 31 47852 5811 63435328
Blood creatinine increased 33.34 12.38 143 47740 87701 63353438
Normal newborn 33.10 12.38 36 47847 8305 63432834
Leukaemoid reaction 32.97 12.38 10 47873 173 63440966
CSF measles antibody positive 32.81 12.38 8 47875 57 63441082
Hepatitis infectious mononucleosis 32.71 12.38 9 47874 108 63441031
Weber tuning fork test abnormal 32.56 12.38 9 47874 110 63441029
Hypertransaminasaemia 32.49 12.38 32 47851 6577 63434562
Cyanosis 32.40 12.38 51 47832 16884 63424255
Hypoaesthesia 32.36 12.38 48 47835 168345 63272794
Oliguria 32.21 12.38 37 47846 9064 63432075
Rubella antibody positive 32.00 12.38 8 47875 64 63441075
Mitochondrial DNA mutation 31.88 12.38 12 47871 410 63440729
Unresponsive to stimuli 31.43 12.38 75 47808 33741 63407398
Lip oedema 31.31 12.38 25 47858 3899 63437240
Enterobacter infection 31.23 12.38 20 47863 2207 63438932
Aspartate aminotransferase increased 30.52 12.38 142 47741 90135 63351004
Intentional overdose 30.51 12.38 9 47874 74143 63366996
Death 30.51 12.38 162 47721 374219 63066920
Hepatic function abnormal 29.92 12.38 78 47805 37064 63404075
Sneezing 29.64 12.38 51 47832 18167 63422972
Neurotoxicity 29.55 12.38 49 47834 16941 63424198
Blood brain barrier defect 29.47 12.38 8 47875 91 63441048
Systemic inflammatory response syndrome 29.10 12.38 28 47855 5593 63435546
Back pain 29.04 12.38 102 47781 264043 63177096
Agitation 28.91 12.38 105 47778 59652 63381487
Dyspepsia 28.80 12.38 21 47862 102175 63338964
Hypotension 28.65 12.38 323 47560 272281 63168858
Sleep disorder 28.34 12.38 13 47870 81553 63359586
Adverse event 28.16 12.38 8 47875 67551 63373588
Gastroenteritis clostridial 27.94 12.38 12 47871 580 63440559
Fibrin D dimer increased 27.83 12.38 26 47857 5008 63436131
Dermatitis exfoliative generalised 27.73 12.38 23 47860 3784 63437355
Blood gases abnormal 27.56 12.38 13 47870 784 63440355
Haemoperitoneum 27.46 12.38 20 47863 2721 63438418
Memory impairment 27.39 12.38 23 47860 104235 63336904
Multiple-drug resistance 27.24 12.38 26 47857 5144 63435995
Alanine aminotransferase increased 27.22 12.38 152 47731 103618 63337521
Feeling abnormal 26.89 12.38 44 47839 148348 63292791
Laryngeal stenosis 26.66 12.38 14 47869 1064 63440075
Bile duct stone 26.45 12.38 22 47861 3634 63437505
Factor V deficiency 26.17 12.38 7 47876 75 63441064
Dry mouth 26.14 12.38 13 47870 77850 63363289
COVID-19 pneumonia 26.09 12.38 42 47841 14167 63426972
Electrolyte imbalance 26.09 12.38 51 47832 20025 63421114
Drug abuse 26.07 12.38 11 47872 72507 63368632
Cholestatic liver injury 26.05 12.38 19 47864 2591 63438548
CSF protein increased 26.05 12.38 11 47872 510 63440629
Pelvic inflammatory disease 26.00 12.38 16 47867 1646 63439493
Gene mutation 25.98 12.38 16 47867 1649 63439490
Autoimmune haemolytic anaemia 25.89 12.38 24 47859 4577 63436562
Face oedema 25.85 12.38 51 47832 20161 63420978
Erythema multiforme 25.81 12.38 35 47848 10134 63431005
Hepatitis acute 25.63 12.38 33 47850 9087 63432052
Balance disorder 25.60 12.38 16 47867 84406 63356733
Escherichia infection 25.22 12.38 39 47844 12715 63428424
Cardiogenic shock 25.08 12.38 47 47836 17885 63423254
Toxic skin eruption 24.92 12.38 39 47844 12846 63428293
Bronchial obstruction 24.84 12.38 15 47868 1492 63439647
Nephropathy toxic 24.63 12.38 33 47850 9446 63431693
Intervertebral discitis 24.56 12.38 20 47863 3208 63437931
Anuria 24.29 12.38 38 47845 12513 63428626
Disseminated intravascular coagulation 24.28 12.38 48 47835 19003 63422136
Blood pressure increased 24.16 12.38 54 47829 162008 63279131
Eosinophilic pneumonia 24.14 12.38 17 47866 2194 63438945
Clostridium colitis 23.93 12.38 16 47867 1898 63439241
Palpitations 23.82 12.38 30 47853 112740 63328399
Therapeutic product effect incomplete 23.68 12.38 36 47847 125020 63316119
Hyporesponsive to stimuli 23.56 12.38 13 47870 1091 63440048
Organic brain syndrome 23.50 12.38 8 47875 203 63440936
Musculoskeletal pain 23.46 12.38 21 47862 92256 63348883
Abdominal wall haematoma 23.39 12.38 19 47864 3036 63438103
Muscle tension dysphonia 23.39 12.38 8 47875 206 63440933
Coombs negative haemolytic anaemia 23.32 12.38 8 47875 208 63440931
Suicidal ideation 23.20 12.38 9 47874 62412 63378727
Renal tubular necrosis 23.04 12.38 36 47847 11842 63429297
Vascular device infection 23.01 12.38 28 47855 7284 63433855
Full blood count abnormal 22.92 12.38 64 47819 31653 63409486
Thunderclap headache 22.79 12.38 8 47875 223 63440916
Lacrimation increased 22.78 12.38 49 47834 20582 63420557
Cholangitis acute 22.63 12.38 10 47873 518 63440621
Anxiety 22.58 12.38 86 47797 217455 63223684
Eye pruritus 22.55 12.38 46 47837 18625 63422514
Encephalitis brain stem 22.47 12.38 7 47876 133 63441006
Blood pressure fluctuation 22.27 12.38 4 47879 46313 63394826
Haemostasis 22.17 12.38 8 47875 242 63440897
Type IV hypersensitivity reaction 22.14 12.38 18 47865 2880 63438259
Jaundice 22.11 12.38 60 47823 29191 63411948
Product use in unapproved indication 21.99 12.38 219 47664 178861 63262278
Pyelonephritis acute 21.95 12.38 22 47861 4619 63436520
Otitis media acute 21.85 12.38 12 47871 998 63440141
Myocardial infarction 21.70 12.38 26 47857 99867 63341272
Multiple sclerosis relapse 21.62 12.38 5 47878 48473 63392666
Hyperbilirubinaemia 21.54 12.38 34 47849 11280 63429859
Haemodialysis 21.51 12.38 30 47853 8917 63432222
Endocarditis 21.40 12.38 24 47859 5726 63435413
Renal papillary necrosis 21.40 12.38 8 47875 268 63440871
Bacteriuria 21.38 12.38 12 47871 1041 63440098
Paraesthesia 21.26 12.38 55 47828 156911 63284228
Hospitalisation 20.87 12.38 20 47863 85061 63356078
Veillonella infection 20.84 12.38 5 47878 33 63441106
Drug eruption 20.84 12.38 58 47825 28636 63412503
Coagulation factor deficiency 20.72 12.38 4 47879 7 63441132
Pneumonia necrotising 20.71 12.38 9 47874 448 63440691
Pancreatitis necrotising 20.66 12.38 14 47869 1698 63439441
Hyperglycaemia 20.62 12.38 74 47809 41793 63399346
Laryngeal mass 20.58 12.38 5 47878 35 63441104
Rhinocerebral mucormycosis 20.56 12.38 9 47874 456 63440683
Morganella infection 20.34 12.38 10 47873 661 63440478
Confabulation 20.25 12.38 8 47875 312 63440827
Meningitis 20.22 12.38 26 47857 7151 63433988
Iris transillumination defect 20.10 12.38 6 47877 98 63441041
Meningism 20.02 12.38 9 47874 486 63440653
Encephalitis autoimmune 19.99 12.38 13 47870 1473 63439666
Cataract 19.96 12.38 9 47874 57044 63384095
Infection 19.87 12.38 97 47786 229076 63212063
Type I hypersensitivity 19.84 12.38 17 47866 2925 63438214
Influenza like illness 19.80 12.38 13 47870 66811 63374328
Myocarditis 19.62 12.38 31 47852 10294 63430845
Foetal death 19.54 12.38 32 47851 10948 63430191
Intravascular haemolysis 19.53 12.38 8 47875 343 63440796
Postpartum sepsis 19.48 12.38 4 47879 11 63441128
Hepatosplenomegaly 19.48 12.38 16 47867 2598 63438541
Eyelid oedema 19.28 12.38 31 47852 10448 63430691
Erythema nodosum 19.27 12.38 21 47862 4854 63436285
Aspergillus infection 19.26 12.38 27 47856 8066 63433073
Bronchopleural fistula 19.21 12.38 7 47876 218 63440921
Transverse sinus thrombosis 18.99 12.38 9 47874 549 63440590
Acquired haemophilia 18.92 12.38 11 47872 1020 63440119
Blood potassium decreased 18.79 12.38 72 47811 41954 63399185
Stress 18.67 12.38 14 47869 67153 63373986
Conjunctival hyperaemia 18.65 12.38 15 47868 2364 63438775
Red blood cell agglutination 18.57 12.38 3 47880 0 63441139
Anti factor V antibody 18.57 12.38 3 47880 0 63441139
Acute hepatic failure 18.51 12.38 42 47841 18285 63422854
Meningitis bacterial 18.49 12.38 12 47871 1355 63439784
Gastric disorder 18.47 12.38 3 47880 37366 63403773
Respiratory acidosis 18.41 12.38 24 47859 6691 63434448
Dry skin 18.35 12.38 10 47873 56877 63384262
Visual impairment 18.32 12.38 22 47861 84424 63356715
Inflammatory marker increased 18.06 12.38 24 47859 6815 63434324
Eosinophilic pneumonia acute 18.04 12.38 8 47875 418 63440721
Mixed liver injury 18.03 12.38 20 47863 4715 63436424
Bronchospasm 17.90 12.38 40 47843 17240 63423899
Bacteraemia 17.79 12.38 40 47843 17308 63423831
Gastrooesophageal reflux disease 17.66 12.38 28 47855 95611 63345528
Hypofibrinogenaemia 17.64 12.38 11 47872 1159 63439980
Injection site pruritus 17.62 12.38 6 47877 45110 63396029
Hyperthyroidism 17.54 12.38 36 47847 14637 63426502
Clostridial infection 17.50 12.38 19 47864 4373 63436766
Lactic acidosis 17.45 12.38 66 47817 38221 63402918
Purpura 17.39 12.38 31 47852 11354 63429785
Cholecystitis acute 17.38 12.38 26 47857 8234 63432905
Herpes zoster 17.35 12.38 22 47861 82440 63358699
Asymptomatic bacteriuria 17.34 12.38 7 47876 289 63440850
Normochromic anaemia 17.30 12.38 7 47876 291 63440848
Cerebral artery stenosis 17.13 12.38 8 47875 472 63440667
Foetal exposure during pregnancy 17.04 12.38 58 47825 31904 63409235
Pseudophaeochromocytoma 17.03 12.38 5 47878 77 63441062
Vision blurred 16.89 12.38 27 47856 91897 63349242
Therapeutic response decreased 16.87 12.38 13 47870 61512 63379627
Unmasking of previously unidentified disease 16.83 12.38 10 47873 966 63440173
Hyperpyrexia 16.78 12.38 17 47866 3615 63437524
Haematoma 16.68 12.38 61 47822 34759 63406380
Septic pulmonary embolism 16.68 12.38 5 47878 83 63441056
Skin test positive 16.68 12.38 9 47874 723 63440416
Nocardiosis 16.65 12.38 13 47870 1963 63439176
Hypoalbuminaemia 16.58 12.38 31 47852 11774 63429365
Antibiotic associated colitis 16.50 12.38 3 47880 3 63441136
Ventricular fibrillation 16.47 12.38 31 47852 11836 63429303
Sciatica 16.43 12.38 3 47880 34321 63406818
Infantile apnoea 16.30 12.38 10 47873 1023 63440116
Hyperlactacidaemia 16.30 12.38 15 47868 2834 63438305
Foetal growth restriction 16.22 12.38 24 47859 7529 63433610
Anaemia 16.21 12.38 311 47572 293119 63148020
Bursitis 16.17 12.38 4 47879 37037 63404102
Relapsing fever 16.11 12.38 6 47877 199 63440940
Device related bacteraemia 16.05 12.38 6 47877 201 63440938
Coagulation factor decreased 16.05 12.38 5 47878 95 63441044
Blood creatine phosphokinase increased 16.03 12.38 55 47828 30375 63410764
Inappropriate schedule of product administration 16.02 12.38 34 47849 103931 63337208
Hyperkalaemia 15.98 12.38 82 47801 54121 63387018
Wound haemorrhage 15.88 12.38 14 47869 2502 63438637
Hypercreatininaemia 15.81 12.38 8 47875 563 63440576
Idiosyncratic drug reaction 15.64 12.38 9 47874 819 63440320
Hyperthermia malignant 15.58 12.38 9 47874 825 63440314
Ear pain 15.57 12.38 4 47879 36114 63405025
Generalised bullous fixed drug eruption 15.53 12.38 5 47878 106 63441033
Toxicity to various agents 15.46 12.38 116 47767 247134 63194005
Anoxia 15.29 12.38 6 47877 230 63440909
Post treatment Lyme disease syndrome 15.28 12.38 3 47880 6 63441133
Fixed eruption 15.21 12.38 10 47873 1154 63439985
Night sweats 15.15 12.38 9 47874 48805 63392334
Pancreatitis acute 15.11 12.38 50 47833 27116 63414023
Adverse drug reaction 15.04 12.38 23 47860 79691 63361448
Arthritis reactive 15.02 12.38 7 47876 411 63440728
Thrombosis 14.99 12.38 16 47867 64739 63376400
Candida test positive 14.98 12.38 9 47874 887 63440252
Septic embolus 14.97 12.38 9 47874 888 63440251
Gamma-glutamyltransferase increased 14.96 12.38 58 47825 33973 63407166
Anticonvulsant drug level below therapeutic 14.96 12.38 8 47875 631 63440508
Cerebral aspergillosis 14.95 12.38 7 47876 415 63440724
Stomatococcal infection 14.95 12.38 5 47878 120 63441019
Brain herniation 14.82 12.38 16 47867 3661 63437478
Pneumonia mycoplasmal 14.71 12.38 9 47874 916 63440223
Vitamin K deficiency 14.68 12.38 7 47876 433 63440706
Ureterolithiasis 14.65 12.38 12 47871 1940 63439199
Generalised oedema 14.61 12.38 35 47848 15783 63425356
Ventricular dysfunction 14.48 12.38 14 47869 2814 63438325
Amniotic cavity infection 14.47 12.38 10 47873 1253 63439886
Central nervous system vasculitis 14.46 12.38 9 47874 945 63440194
Chemotherapeutic drug level increased 14.36 12.38 5 47878 136 63441003
Constipation 14.32 12.38 105 47778 224838 63216301
Hypertensive heart disease 14.20 12.38 13 47870 2439 63438700
Petechiae 14.20 12.38 32 47851 13865 63427274
Anti-platelet antibody positive 14.18 12.38 4 47879 53 63441086
Hyperthermia 14.07 12.38 25 47858 9131 63432008
Nephritis 13.92 12.38 13 47870 2503 63438636
Drug hypersensitivity 13.81 12.38 319 47564 310368 63130771
Condition aggravated 13.80 12.38 399 47484 401818 63039321
Eye inflammation 13.80 12.38 19 47864 5580 63435559
Orthostatic hypotension 13.80 12.38 5 47878 36155 63404984
Granulomatous dermatitis 13.71 12.38 5 47878 156 63440983
Localised infection 13.71 12.38 3 47880 30207 63410932
Stridor 13.67 12.38 15 47868 3495 63437644
Fluid retention 13.54 12.38 15 47868 59671 63381468
Alpha 1 microglobulin increased 13.48 12.38 4 47879 64 63441075
Apgar score low 13.43 12.38 8 47875 776 63440363
Superior sagittal sinus thrombosis 13.37 12.38 8 47875 783 63440356
Prescribed underdose 13.37 12.38 3 47880 29686 63411453
Dysmetria 13.35 12.38 7 47876 530 63440609
Decreased appetite 13.33 12.38 123 47760 250929 63190210
Joint injury 13.29 12.38 3 47880 29569 63411570
Deafness bilateral 13.28 12.38 10 47873 1432 63439707
Dysphemia 13.24 12.38 13 47870 2662 63438477
Loss of personal independence in daily activities 13.24 12.38 34 47849 97256 63343883
Hemianopia 13.24 12.38 9 47874 1098 63440041
Oropharyngeal discomfort 13.19 12.38 18 47865 5242 63435897
Muscle haemorrhage 13.10 12.38 14 47869 3165 63437974
Sleep apnoea syndrome 13.00 12.38 3 47880 29130 63412009
Cardiac tamponade 12.99 12.38 17 47866 4758 63436381
Splenomegaly 12.90 12.38 27 47856 11130 63430009
Systemic candida 12.87 12.38 14 47869 3231 63437908
Procalcitonin increased 12.86 12.38 9 47874 1150 63439989
Muscle strength abnormal 12.84 12.38 4 47879 76 63441063
Hypoxic-ischaemic encephalopathy 12.82 12.38 16 47867 4271 63436868
Foaming at mouth 12.80 12.38 9 47874 1159 63439980
Peri-implantitis 12.79 12.38 4 47879 77 63441062
Chest discomfort 12.77 12.38 133 47750 109836 63331303
Base excess 12.74 12.38 4 47879 78 63441061
Vaccination complication 12.74 12.38 9 47874 1168 63439971
Normocytic anaemia 12.66 12.38 11 47872 1929 63439210
Dysgeusia 12.64 12.38 10 47873 46700 63394439
Febrile infection 12.59 12.38 10 47873 1547 63439592
Chorioretinitis 12.57 12.38 7 47876 598 63440541
Blood urea increased 12.46 12.38 46 47837 26333 63414806
Leukoencephalopathy 12.45 12.38 16 47867 4397 63436742
Overlap syndrome 12.45 12.38 8 47875 888 63440251
Staphylococcus test positive 12.39 12.38 15 47868 3881 63437258
Microangiopathic haemolytic anaemia 12.38 12.38 7 47876 616 63440523

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 512.53 12.17 1586 51158 417938 34486249
Drug reaction with eosinophilia and systemic symptoms 445.03 12.17 381 52363 32631 34871556
Postrenal failure 291.90 12.17 78 52666 377 34903810
Jarisch-Herxheimer reaction 262.79 12.17 76 52668 515 34903672
Appendicolith 235.18 12.17 152 52592 8449 34895738
Pseudocholelithiasis 225.43 12.17 41 52703 0 34904187
Rash maculo-papular 197.65 12.17 229 52515 28222 34875965
Appendicitis 197.54 12.17 170 52574 14637 34889550
Multiple organ dysfunction syndrome 185.08 12.17 377 52367 76189 34827998
Fatigue 173.17 12.17 183 52561 370470 34533717
Acute generalised exanthematous pustulosis 171.24 12.17 114 52630 6662 34897525
Cardiogenic shock 169.59 12.17 205 52539 26413 34877774
Acute kidney injury 163.03 12.17 896 51848 304092 34600095
Hepatocellular injury 159.68 12.17 182 52562 22029 34882158
Toxic epidermal necrolysis 135.09 12.17 165 52579 21481 34882706
Cholelithiasis 133.27 12.17 162 52582 20986 34883201
Cholestasis 133.13 12.17 183 52561 26765 34877422
Eosinophilia 132.46 12.17 180 52564 26042 34878145
Agranulocytosis 131.83 12.17 171 52573 23650 34880537
Death 129.15 12.17 254 52490 397795 34506392
Hypertransaminasaemia 119.65 12.17 85 52659 5521 34898666
Toxic encephalopathy 117.63 12.17 82 52662 5167 34899020
Drug ineffective for unapproved indication 115.57 12.17 160 52584 23555 34880632
Drug abuse 115.42 12.17 9 52735 99087 34805100
Product dose omission issue 112.54 12.17 22 52722 119689 34784498
Ventricular fibrillation 110.56 12.17 154 52590 22800 34881387
Kounis syndrome 103.91 12.17 58 52686 2460 34901727
Anaphylactic shock 103.51 12.17 124 52620 15817 34888370
Pathogen resistance 101.12 12.17 96 52648 9386 34894801
Pyrexia 100.48 12.17 850 51894 332163 34572024
Dizziness 99.42 12.17 110 52634 218411 34685776
Anaphylactic reaction 93.78 12.17 172 52572 32129 34872058
Hepatitis 92.93 12.17 145 52599 23759 34880428
Clostridium test positive 91.19 12.17 59 52685 3283 34900904
Fall 90.23 12.17 104 52640 202781 34701406
Ascites 89.27 12.17 209 52535 46362 34857825
Blood phosphorus increased 87.77 12.17 81 52663 7640 34896547
Stress 87.35 12.17 161 52583 30186 34874001
Clostridium difficile colitis 87.14 12.17 113 52631 15617 34888570
Drug-induced liver injury 86.84 12.17 156 52588 28676 34875511
Depression 86.83 12.17 20 52724 97078 34807109
Ureterolithiasis 85.45 12.17 49 52695 2190 34901997
Bronchopulmonary aspergillosis 83.87 12.17 107 52637 14552 34889635
Factor V inhibition 81.69 12.17 24 52720 173 34904014
Haemolytic anaemia 80.65 12.17 89 52655 10390 34893797
Recalled product administered 78.95 12.17 30 52714 511 34903676
Long QT syndrome 77.75 12.17 50 52694 2753 34901434
Respiratory failure 76.83 12.17 346 52398 108226 34795961
Weight increased 75.90 12.17 23 52721 93010 34811177
Immune reconstitution inflammatory syndrome 73.73 12.17 78 52666 8681 34895506
Hyponatraemia 71.33 12.17 280 52464 82411 34821776
Condition aggravated 68.95 12.17 511 52233 191685 34712502
Pain 68.40 12.17 128 52616 204547 34699640
Septic shock 67.52 12.17 250 52494 71584 34832603
Haemolysis 62.73 12.17 69 52675 8025 34896162
Alanine aminotransferase increased 58.99 12.17 260 52484 80555 34823632
Tubulointerstitial nephritis 58.56 12.17 110 52634 20914 34883273
Myocardial infarction 58.30 12.17 58 52686 121027 34783160
Insomnia 55.73 12.17 45 52699 103862 34800325
Hydronephrosis 55.25 12.17 73 52671 10273 34893914
Joint swelling 54.20 12.17 12 52732 59878 34844309
Electrocardiogram QT prolonged 53.16 12.17 159 52585 40793 34863394
Stevens-Johnson syndrome 52.51 12.17 98 52646 18541 34885646
Acute respiratory distress syndrome 52.44 12.17 119 52625 25850 34878337
Abdominal discomfort 52.14 12.17 13 52731 59822 34844365
Liver injury 52.00 12.17 86 52658 14792 34889395
Nocardiosis 51.94 12.17 45 52699 3906 34900281
Toxicity to various agents 51.75 12.17 144 52600 200218 34703969
Cerebrovascular accident 51.70 12.17 32 52712 84779 34819408
Arthralgia 50.28 12.17 114 52630 169927 34734260
Blood glucose increased 50.05 12.17 19 52725 66699 34837488
Sepsis 49.37 12.17 424 52320 166137 34738050
Klebsiella infection 48.37 12.17 62 52682 8469 34895718
Hospitalisation 48.37 12.17 13 52731 56889 34847298
Brain abscess 48.13 12.17 39 52705 3086 34901101
Trichosporon infection 47.88 12.17 23 52721 711 34903476
Drug ineffective 47.73 12.17 959 51785 455792 34448395
Anuria 47.51 12.17 68 52676 10317 34893870
Rash morbilliform 46.43 12.17 38 52706 3049 34901138
Inappropriate schedule of product administration 46.30 12.17 18 52726 62278 34841909
Anxiety 46.29 12.17 49 52695 99379 34804808
Mucormycosis 44.91 12.17 50 52694 5892 34898295
Abdominal distension 44.82 12.17 191 52553 58301 34845886
Pain in extremity 44.10 12.17 77 52667 126436 34777751
Disseminated intravascular coagulation 44.08 12.17 100 52644 21716 34882471
Cross sensitivity reaction 43.97 12.17 27 52717 1370 34902817
Asthenia 43.05 12.17 207 52537 245044 34659143
Candida infection 42.44 12.17 87 52657 17628 34886559
Nasopharyngitis 41.81 12.17 27 52717 69941 34834246
Disseminated cryptococcosis 41.63 12.17 26 52718 1360 34902827
Transaminases increased 41.51 12.17 111 52633 26712 34877475
Product use in unapproved indication 41.25 12.17 311 52433 117188 34786999
Ureteral disorder 40.73 12.17 14 52730 176 34904011
Toxic skin eruption 40.04 12.17 66 52678 11319 34892868
Cardiac failure congestive 39.93 12.17 40 52704 83230 34820957
Clostridium difficile infection 39.72 12.17 88 52656 18810 34885377
Muscle spasms 39.56 12.17 33 52711 74968 34829219
Inflammatory marker increased 39.20 12.17 43 52701 4985 34899202
Diarrhoea 38.36 12.17 390 52354 389522 34514665
Feeling abnormal 36.98 12.17 25 52719 63210 34840977
COVID-19 pneumonia 36.78 12.17 80 52664 16887 34887300
Cryptococcal meningoencephalitis 36.77 12.17 12 52732 127 34904060
Portal fibrosis 36.45 12.17 15 52729 318 34903869
Headache 35.38 12.17 169 52575 200466 34703721
Dehydration 35.34 12.17 91 52653 129878 34774309
Bacterial pericarditis 35.33 12.17 10 52734 62 34904125
Thrombocytopenia 34.99 12.17 375 52369 155872 34748315
Cardiac disorder 34.54 12.17 11 52733 43115 34861072
Coronary artery disease 34.20 12.17 15 52729 48290 34855897
Myasthenia gravis 34.06 12.17 47 52697 6893 34897294
Encephalitis 33.80 12.17 48 52696 7229 34896958
Intentional overdose 33.49 12.17 12 52732 43662 34860525
Therapeutic product effect decreased 33.44 12.17 6 52738 34737 34869450
Gait disturbance 33.27 12.17 48 52696 85092 34819095
Liver function test increased 33.10 12.17 70 52674 14495 34889692
Hepatitis fulminant 32.95 12.17 36 52708 4154 34900033
Hepatitis toxic 32.00 12.17 27 52717 2260 34901927
Weight decreased 31.96 12.17 147 52597 176154 34728033
Leukocytosis 31.76 12.17 94 52650 23971 34880216
Drug hypersensitivity 31.61 12.17 219 52525 80310 34823877
Torsade de pointes 31.22 12.17 46 52698 7163 34897024
Hepatitis acute 30.78 12.17 47 52697 7554 34896633
Hepatitis cholestatic 30.58 12.17 48 52696 7899 34896288
Malignant neoplasm progression 30.29 12.17 54 52690 87992 34816195
Myasthenia gravis crisis 30.20 12.17 16 52728 611 34903576
Blood uric acid increased 30.15 12.17 53 52691 9571 34894616
Arthropathy 29.80 12.17 3 52741 26904 34877283
Contusion 29.62 12.17 9 52735 36355 34867832
Flank pain 29.62 12.17 43 52701 6608 34897579
Urticaria 29.61 12.17 178 52566 62199 34841988
Pruritus 29.60 12.17 336 52408 141645 34762542
Choreoathetosis 29.56 12.17 19 52725 1045 34903142
Drug resistance 29.33 12.17 96 52648 25831 34878356
Hypoxia 29.28 12.17 162 52582 54933 34849254
Pseudomembranous colitis 29.26 12.17 28 52716 2763 34901424
Crying 29.22 12.17 40 52704 5822 34898365
Chest pain 29.18 12.17 96 52648 126666 34777521
Alcohol intolerance 29.17 12.17 14 52730 432 34903755
Hyperferritinaemia 29.11 12.17 14 52730 434 34903753
Malignant mesenteric neoplasm 29.08 12.17 8 52736 44 34904143
Sphincter of Oddi dysfunction 29.07 12.17 10 52734 126 34904061
Prostate cancer 28.57 12.17 12 52732 39637 34864550
Crystalluria 28.16 12.17 14 52730 467 34903720
Peripheral swelling 28.12 12.17 45 52699 76496 34827691
Malaise 28.02 12.17 165 52579 185660 34718527
Hepatic enzyme increased 27.93 12.17 125 52619 38955 34865232
Escherichia infection 27.92 12.17 47 52697 8198 34895989
Suicidal ideation 27.88 12.17 13 52731 40375 34863812
Mycotic endophthalmitis 27.86 12.17 9 52735 92 34904095
Acute hepatic failure 27.86 12.17 64 52680 14010 34890177
Fixed eruption 27.85 12.17 22 52722 1678 34902509
Respiratory distress 27.72 12.17 117 52627 35548 34868639
Hypertension 27.65 12.17 109 52635 136334 34767853
Hyper IgE syndrome 27.56 12.17 8 52736 55 34904132
Blood pressure fluctuation 27.48 12.17 3 52741 25246 34878941
Corynebacterium infection 27.45 12.17 15 52729 610 34903577
Tachypnoea 27.44 12.17 75 52669 18277 34885910
Wrong technique in product usage process 27.40 12.17 10 52734 35976 34868211
Procalcitonin increased 27.28 12.17 22 52722 1729 34902458
Hepatomegaly 27.23 12.17 53 52691 10343 34893844
Cerebral cyst 27.04 12.17 12 52732 308 34903879
Cheilitis 27.01 12.17 25 52719 2366 34901821
Neuropathy peripheral 26.94 12.17 53 52691 83210 34820977
Memory impairment 26.87 12.17 16 52728 43302 34860885
Intervertebral discitis 26.85 12.17 24 52720 2171 34902016
Device related sepsis 26.84 12.17 28 52716 3065 34901122
Jaundice 26.68 12.17 107 52637 31775 34872412
Enterobacter infection 26.66 12.17 25 52719 2405 34901782
Dry gangrene 26.36 12.17 13 52731 426 34903761
Back pain 26.16 12.17 95 52649 121694 34782493
Syncope 25.65 12.17 63 52681 91388 34812799
Janeway lesion 25.49 12.17 6 52738 15 34904172
Blood pressure increased 25.25 12.17 60 52684 88042 34816145
Balance disorder 25.24 12.17 15 52729 40639 34863548
Cyanosis 25.22 12.17 58 52686 12706 34891481
Drug effective for unapproved indication 25.21 12.17 25 52719 2577 34901610
Drug interaction 24.99 12.17 479 52265 225467 34678720
Vascular purpura 24.90 12.17 21 52723 1757 34902430
Hyperphosphataemia 24.76 12.17 32 52712 4405 34899782
Abdominal pain 24.73 12.17 365 52379 163253 34740934
Aspartate aminotransferase increased 24.66 12.17 181 52563 67602 34836585
Hepatic function abnormal 24.61 12.17 132 52612 44231 34859956
Vision blurred 24.51 12.17 20 52724 45943 34858244
Type IV hypersensitivity reaction 24.45 12.17 19 52725 1415 34902772
Jejunal ulcer perforation 24.40 12.17 8 52736 86 34904101
Metastases to stomach 24.40 12.17 8 52736 86 34904101
Haemodynamic instability 24.28 12.17 48 52696 9475 34894712
General physical health deterioration 24.27 12.17 298 52446 127971 34776216
Shock 24.25 12.17 86 52658 24093 34880094
Serum sickness-like reaction 24.09 12.17 9 52735 146 34904041
Transient ischaemic attack 24.05 12.17 6 52738 27607 34876580
Allergy test positive 24.00 12.17 8 52736 91 34904096
Loss of personal independence in daily activities 23.97 12.17 10 52734 33169 34871018
Incorrect dose administered 23.70 12.17 16 52728 40499 34863688
Drug dependence 23.70 12.17 4 52740 24213 34879974
Pleocytosis 23.56 12.17 13 52731 539 34903648
Aspergillus infection 23.46 12.17 55 52689 12199 34891988
Analgesic therapy 23.32 12.17 16 52728 982 34903205
Endocarditis 23.24 12.17 38 52706 6473 34897714
Drug eruption 22.80 12.17 74 52670 19824 34884363
Dermatitis exfoliative generalised 22.70 12.17 28 52716 3679 34900508
Systemic candida 22.58 12.17 28 52716 3698 34900489
No adverse event 22.53 12.17 81 52663 22846 34881341
Oliguria 22.29 12.17 43 52701 8337 34895850
Omental necrosis 22.28 12.17 6 52738 30 34904157
Cataract 22.21 12.17 6 52738 26180 34878007
Acute respiratory failure 22.15 12.17 99 52645 30829 34873358
Coagulopathy 22.14 12.17 73 52671 19716 34884471
Injection site pain 22.03 12.17 16 52728 38989 34865198
Procalcitonin abnormal 22.02 12.17 11 52733 371 34903816
Infective chondritis 22.01 12.17 5 52739 10 34904177
Blood alkaline phosphatase increased 21.74 12.17 99 52645 31076 34873111
Dry skin 21.70 12.17 10 52734 31277 34872910
Overdose 21.61 12.17 68 52676 90991 34813196
Encephalopathy 21.61 12.17 108 52636 35211 34868976
Hepatic cytolysis 21.43 12.17 59 52685 14437 34889750
Drug therapy 21.39 12.17 16 52728 1125 34903062
Bacterial parotitis 21.37 12.17 6 52738 36 34904151
Intracranial pressure increased 21.26 12.17 28 52716 3927 34900260
Cryptococcosis 21.17 12.17 22 52722 2397 34901790
Erectile dysfunction 21.13 12.17 3 52741 20634 34883553
Malabsorption from administration site 20.97 12.17 7 52737 80 34904107
Eastern Cooperative Oncology Group performance status 20.96 12.17 6 52738 39 34904148
Tissue infiltration 20.89 12.17 7 52737 81 34904106
Coagulation factor decreased 20.66 12.17 7 52737 84 34904103
Dyspnoea 20.65 12.17 423 52321 376359 34527828
Psoriasis 20.55 12.17 17 52727 38795 34865392
Red blood cell schistocytes present 20.10 12.17 9 52735 236 34903951
Liver transplant failure 20.08 12.17 7 52737 92 34904095
Orthostatic hypotension 20.07 12.17 7 52737 25912 34878275
Stenotrophomonas infection 19.94 12.17 20 52724 2090 34902097
Splenomegaly 19.89 12.17 59 52685 15058 34889129
Neurotoxicity 19.76 12.17 66 52678 17944 34886243
Muscle abscess 19.56 12.17 12 52732 608 34903579
Antinuclear antibody negative 19.47 12.17 5 52739 20 34904167
Antimicrobial susceptibility test resistant 19.31 12.17 10 52734 364 34903823
Amnesia 19.20 12.17 8 52736 26555 34877632
Hypoaesthesia 19.11 12.17 40 52704 61404 34842783
Neutropenia 18.92 12.17 337 52407 156441 34747746
Pulmonary physical examination abnormal 18.91 12.17 5 52739 23 34904164
Shock haemorrhagic 18.60 12.17 48 52696 11306 34892881
Neoplasm progression 18.56 12.17 6 52738 23294 34880893
Sleep apnoea syndrome 18.52 12.17 4 52740 20317 34883870
Faeces pale 18.48 12.17 16 52728 1387 34902800
Vanishing bile duct syndrome 18.48 12.17 14 52730 1004 34903183
Erythema 18.43 12.17 210 52534 88570 34815617
Gastrooesophageal reflux disease 18.42 12.17 18 52726 37906 34866281
Sleep disorder therapy 18.42 12.17 14 52730 1009 34903178
Bile duct stone 18.31 12.17 21 52723 2556 34901631
Arteriospasm coronary 18.26 12.17 24 52720 3358 34900829
Contraindicated product administered 18.07 12.17 5 52739 21476 34882711
Antibiotic level below therapeutic 18.02 12.17 6 52738 68 34904119
Low birth weight baby 17.97 12.17 38 52706 7867 34896320
Vitamin A deficiency 17.95 12.17 5 52739 29 34904158
Basal cell carcinoma 17.65 12.17 4 52740 19654 34884533
Unevaluable event 17.60 12.17 14 52730 32576 34871611
Interleukin-2 receptor increased 17.57 12.17 7 52737 136 34904051
Influenza 17.49 12.17 30 52714 49636 34854551
Haemophagocytic lymphohistiocytosis 17.42 12.17 51 52693 12922 34891265
Suicide attempt 17.39 12.17 20 52724 39096 34865091
Peritoneal dialysis 17.34 12.17 11 52733 591 34903596
Decreased appetite 17.30 12.17 164 52580 166228 34737959
Abdominal compartment syndrome 17.06 12.17 13 52731 940 34903247
White blood cell count decreased 17.02 12.17 80 52664 95365 34808822
Irritability 16.96 12.17 8 52736 24682 34879505
Altered state of consciousness 16.94 12.17 74 52670 22819 34881368
Musculoskeletal pain 16.92 12.17 14 52730 31949 34872238
Gamma-glutamyltransferase increased 16.91 12.17 88 52656 29143 34875044
Hyperamylasaemia 16.89 12.17 11 52733 619 34903568
Cardiac ventricular thrombosis 16.86 12.17 14 52730 1146 34903041
Osteomyelitis fungal 16.72 12.17 8 52736 245 34903942
Erythema nodosum 16.57 12.17 15 52729 1379 34902808
ADAMTS13 activity decreased 16.55 12.17 6 52738 89 34904098
Infective spondylitis 16.54 12.17 8 52736 251 34903936
Bronchopleural fistula 16.54 12.17 10 52734 493 34903694
Calculus urinary 16.45 12.17 15 52729 1392 34902795
Renal papillary necrosis 16.32 12.17 7 52737 165 34904022
Morganella infection 16.20 12.17 10 52734 512 34903675
Cerebellar syndrome 16.20 12.17 19 52725 2369 34901818
Mobility decreased 16.19 12.17 13 52731 30115 34874072
Face oedema 16.17 12.17 46 52698 11470 34892717
Prothrombin time ratio decreased 16.16 12.17 9 52735 380 34903807
Dysgeusia 16.13 12.17 10 52734 26487 34877700
Encephalomalacia 16.02 12.17 12 52732 846 34903341
Hypofibrinogenaemia 15.97 12.17 16 52728 1670 34902517
Palmar-plantar erythrodysaesthesia syndrome 15.94 12.17 3 52741 16792 34887395
Cholecystitis acute 15.87 12.17 32 52712 6407 34897780
Erythema multiforme 15.67 12.17 38 52706 8611 34895576
Carotid artery insufficiency 15.58 12.17 4 52740 16 34904171
Arterial angioplasty 15.58 12.17 5 52739 50 34904137
Chondrocalcinosis 15.56 12.17 9 52735 409 34903778
Disturbance in attention 15.51 12.17 10 52734 25935 34878252
Type IIa hyperlipidaemia 15.38 12.17 7 52737 191 34903996
Herpes zoster reactivation 15.36 12.17 8 52736 295 34903892
Human T-cell lymphotropic virus type I infection 15.20 12.17 4 52740 18 34904169
Palpitations 15.17 12.17 23 52721 39963 34864224
Alopecia 15.09 12.17 9 52735 24346 34879841
Fungaemia 15.09 12.17 19 52725 2549 34901638
Epileptic encephalopathy 15.05 12.17 7 52737 201 34903986
Vomiting 15.02 12.17 484 52260 247137 34657050
Discomfort 14.86 12.17 5 52739 18933 34885254
Tuberculosis of genitourinary system 14.86 12.17 4 52740 20 34904167
Asthma 14.81 12.17 26 52718 42630 34861557
Iron deficiency 14.79 12.17 28 52716 5353 34898834
Influenza like illness 14.76 12.17 12 52732 27622 34876565
Rash 14.73 12.17 440 52304 222312 34681875
Red blood cell sedimentation rate decreased 14.68 12.17 5 52739 61 34904126
Pancytopenia 14.64 12.17 213 52531 94944 34809243
Glucose-6-phosphate dehydrogenase deficiency 14.55 12.17 6 52738 128 34904059
Full blood count abnormal 14.53 12.17 5 52739 18663 34885524
Cholangitis 14.50 12.17 37 52707 8652 34895535
Dyspnoea exertional 14.47 12.17 27 52717 43252 34860935
Delusion of parasitosis 14.42 12.17 3 52741 3 34904184
Pneumonia bacterial 14.37 12.17 45 52699 11827 34892360
Heart rate decreased 14.36 12.17 16 52728 31729 34872458
Henoch-Schonlein purpura 14.34 12.17 15 52729 1647 34902540
Drug withdrawal syndrome 14.29 12.17 6 52738 19828 34884359
Strongyloidiasis 14.27 12.17 19 52725 2692 34901495
Incorrect route of product administration 14.20 12.17 52 52692 14793 34889394
Premature baby 14.17 12.17 63 52681 19570 34884617
Coagulation factor V level decreased 14.09 12.17 7 52737 233 34903954
Delirium 14.06 12.17 114 52630 43877 34860310
Hypercreatininaemia 14.05 12.17 9 52735 492 34903695
Therapeutic product effect incomplete 14.02 12.17 35 52709 50506 34853681
Listeriosis 14.00 12.17 12 52732 1026 34903161
Fluid retention 13.96 12.17 12 52732 26875 34877312
Psychotic disorder 13.85 12.17 10 52734 24442 34879745
Gait inability 13.84 12.17 7 52737 20751 34883436
Metastases to heart 13.70 12.17 6 52738 149 34904038
Meningitis candida 13.68 12.17 5 52739 76 34904111
Status epilepticus 13.63 12.17 46 52698 12568 34891619
Colitis ulcerative 13.61 12.17 4 52740 16516 34887671
Ocular icterus 13.50 12.17 19 52725 2838 34901349
Meningitis bacterial 13.49 12.17 13 52731 1294 34902893
Osteonecrosis 13.43 12.17 3 52741 14887 34889300
Bronchial haemorrhage 13.42 12.17 10 52734 699 34903488
Purpura 13.34 12.17 40 52704 10271 34893916
PO2 decreased 13.16 12.17 14 52730 1567 34902620
Cell death 13.15 12.17 17 52727 2340 34901847
Tremor 13.14 12.17 72 52672 82515 34821672
Adverse event 13.14 12.17 6 52738 18871 34885316
COVID-19 treatment 13.12 12.17 7 52737 271 34903916
Administration site reaction 13.11 12.17 5 52739 86 34904101
Dyspepsia 13.11 12.17 22 52722 36710 34867477
Empyema 13.09 12.17 20 52724 3216 34900971
Migraine 13.06 12.17 5 52739 17473 34886714
Rash erythematous 12.96 12.17 73 52671 24904 34879283
Neuroborreliosis 12.94 12.17 4 52740 35 34904152
Flatulence 12.90 12.17 8 52736 21190 34882997
Enterococcal infection 12.90 12.17 37 52707 9269 34894918
Hypocoagulable state 12.89 12.17 11 52733 935 34903252
Injection site erythema 12.83 12.17 4 52740 15895 34888292
Cardiac arrest 12.78 12.17 210 52534 95949 34808238
Hyperthermia 12.72 12.17 40 52704 10537 34893650
Pollakiuria 12.58 12.17 7 52737 19667 34884520
Surgery 12.48 12.17 3 52741 14154 34890033
Urticarial vasculitis 12.46 12.17 4 52740 40 34904147
Chorioretinitis 12.40 12.17 8 52736 443 34903744
Fibrous dysplasia of bone 12.35 12.17 3 52741 9 34904178
Head injury 12.29 12.17 6 52738 18154 34886033
Ischaemic limb pain 12.29 12.17 4 52740 42 34904145
Ureteric obstruction 12.27 12.17 12 52732 1216 34902971
Haematuria traumatic 12.27 12.17 6 52738 193 34903994
Visual impairment 12.27 12.17 22 52722 35780 34868407
Urinary tract infection fungal 12.24 12.17 8 52736 453 34903734
SJS-TEN overlap 12.20 12.17 7 52737 313 34903874
Lower respiratory tract infection 12.19 12.17 18 52726 31619 34872568

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 1098.89 11.22 774 93837 63470 79586307
Off label use 719.09 11.22 2529 92082 904686 78745091
Pseudocholelithiasis 532.68 11.22 94 94517 7 79649770
Acute generalised exanthematous pustulosis 486.39 11.22 285 94326 16969 79632808
Acute kidney injury 471.99 11.22 1519 93092 517885 79131892
Rash maculo-papular 441.52 11.22 431 94180 55647 79594130
Eosinophilia 427.06 11.22 385 94226 44960 79604817
Multiple organ dysfunction syndrome 423.05 11.22 612 93999 119634 79530143
Toxic epidermal necrolysis 405.12 11.22 371 94240 44210 79605567
Fatigue 391.57 11.22 319 94292 929408 78720369
Postrenal failure 388.12 11.22 101 94510 576 79649201
Jarisch-Herxheimer reaction 376.06 11.22 106 94505 851 79648926
Pain 297.66 11.22 240 94371 703562 78946215
Agranulocytosis 295.92 11.22 314 94297 44716 79605061
Cholelithiasis 285.39 11.22 332 94279 52332 79597445
Cholestasis 278.21 11.22 326 94285 51783 79597994
Completed suicide 270.87 11.22 4 94607 245763 79404014
Appendicolith 266.99 11.22 151 94460 8400 79641377
Joint swelling 266.20 11.22 20 94591 288626 79361151
Clostridium test positive 265.90 11.22 137 94474 6317 79643460
Clostridium difficile colitis 246.34 11.22 244 94367 32039 79617738
Hepatocellular injury 238.00 11.22 288 94323 47305 79602472
Hepatitis 233.88 11.22 309 94302 55418 79594359
Septic shock 226.73 11.22 470 94141 122331 79527446
Arthralgia 215.19 11.22 217 94394 571586 79078191
Haemolytic anaemia 214.02 11.22 174 94437 17646 79632131
Pyrexia 210.92 11.22 1451 93160 677258 78972519
Anaphylactic shock 210.34 11.22 236 94375 35760 79614017
Rheumatoid arthritis 202.39 11.22 11 94600 208459 79441318
Drug ineffective for unapproved indication 195.09 11.22 271 94340 50967 79598810
Cardiogenic shock 194.03 11.22 244 94367 41670 79608107
Appendicitis 192.65 11.22 175 94436 20619 79629158
Factor V inhibition 190.48 11.22 51 94560 330 79649447
Electrocardiogram QT prolonged 188.44 11.22 364 94247 90022 79559755
Arthropathy 186.66 11.22 5 94606 177106 79472671
Respiratory failure 182.77 11.22 550 94061 180361 79469416
Fall 181.15 11.22 187 94424 487442 79162335
Toxic encephalopathy 179.64 11.22 131 94480 11309 79638468
Weight increased 177.90 11.22 54 94557 277332 79372445
Abdominal discomfort 177.56 11.22 40 94571 250687 79399090
Headache 175.22 11.22 318 94293 653454 78996323
Dizziness 174.85 11.22 221 94390 526220 79123557
Alopecia 171.89 11.22 33 94578 231322 79418455
Synovitis 163.74 11.22 3 94608 150731 79499046
Product dose omission issue 159.06 11.22 48 94563 247489 79402288
Stevens-Johnson syndrome 157.91 11.22 213 94398 38953 79610824
Drug-induced liver injury 156.21 11.22 281 94330 65836 79583941
Therapeutic product effect decreased 154.92 11.22 10 94601 163853 79485924
Bronchopulmonary aspergillosis 152.73 11.22 159 94452 22135 79627642
Nasopharyngitis 151.31 11.22 56 94555 253825 79395952
Tubulointerstitial nephritis 149.70 11.22 205 94406 38030 79611747
Drug interaction 145.78 11.22 916 93695 414267 79235510
Pain in extremity 141.96 11.22 134 94477 364404 79285373
Drug intolerance 140.26 11.22 69 94542 264050 79385727
Pathogen resistance 139.36 11.22 124 94487 14218 79635559
Peripheral swelling 139.35 11.22 73 94538 269544 79380233
Sepsis 138.77 11.22 660 93951 268768 79381009
Ventricular fibrillation 138.53 11.22 180 94431 31746 79618031
Long QT syndrome 136.03 11.22 86 94525 5869 79643908
Hypertransaminasaemia 136 11.22 113 94498 11811 79637966
Premature delivery 130.54 11.22 150 94461 23317 79626460
Drug abuse 127.84 11.22 20 94591 162671 79487106
Contraindicated product administered 126.93 11.22 18 94593 157520 79492257
Acute respiratory distress syndrome 120.73 11.22 200 94411 43867 79605910
Leukocytosis 118.75 11.22 197 94414 43258 79606519
Insomnia 117.21 11.22 73 94538 245097 79404680
Contusion 115.29 11.22 19 94592 148757 79501020
Anaphylactic reaction 114.87 11.22 285 94326 83458 79566319
Status epilepticus 114.64 11.22 145 94466 24896 79624881
Clostridium difficile infection 111.97 11.22 190 94421 42495 79607282
Depression 111.55 11.22 59 94552 216731 79433046
Immune reconstitution inflammatory syndrome 110.01 11.22 107 94504 13734 79636043
Hydronephrosis 108.10 11.22 118 94493 17336 79632441
Thrombocytopenia 107.55 11.22 608 94003 264651 79385126
Transaminases increased 106.11 11.22 207 94404 51536 79598241
Ureterolithiasis 101.72 11.22 61 94550 3787 79645990
Glossodynia 101.68 11.22 5 94606 103332 79546445
Kounis syndrome 100.72 11.22 63 94548 4219 79645558
Hepatitis cholestatic 100.68 11.22 102 94509 13750 79636027
Pseudomembranous colitis 99.35 11.22 68 94543 5306 79644471
Wound 99.11 11.22 11 94600 116168 79533609
Haemolysis 98.01 11.22 97 94514 12715 79637062
Malaise 97.19 11.22 280 94331 489589 79160188
Encephalopathy 96.28 11.22 233 94378 67164 79582613
Pemphigus 94.33 11.22 6 94605 99576 79550201
Injection site pain 93.31 11.22 20 94591 129818 79519959
Systemic lupus erythematosus 92.70 11.22 16 94595 121133 79528644
Sinusitis 92.34 11.22 59 94552 195442 79454335
Death 89.78 11.22 357 94254 566157 79083620
Muscle spasms 87.76 11.22 49 94562 174681 79475096
Ascites 87.09 11.22 241 94370 75321 79574456
Discomfort 86.97 11.22 21 94590 125596 79524181
Blood phosphorus increased 86.03 11.22 82 94529 10265 79639512
Tachypnoea 84.46 11.22 143 94468 31920 79617857
Rash morbilliform 82.29 11.22 64 94547 6086 79643691
Gait disturbance 82.20 11.22 75 94536 207431 79442346
Pleocytosis 81.62 11.22 38 94573 1401 79648376
Klebsiella infection 79.98 11.22 96 94515 15624 79634153
Encephalitis 79.83 11.22 93 94518 14667 79635110
Musculoskeletal stiffness 79.69 11.22 55 94556 174953 79474824
Toxicity to various agents 78.51 11.22 248 94363 421292 79228485
Choreoathetosis 78.46 11.22 38 94573 1532 79648245
Cross sensitivity reaction 78.33 11.22 51 94560 3661 79646116
Neutropenia 76.75 11.22 594 94017 287116 79362661
Exposure during pregnancy 76.55 11.22 279 94332 100853 79548924
Mobility decreased 76.09 11.22 25 94586 122150 79527627
Alanine aminotransferase increased 75.57 11.22 387 94224 162183 79487594
Hypoxia 74.94 11.22 281 94330 102962 79546815
Swelling 74.91 11.22 88 94523 216623 79433154
Drug ineffective 74.79 11.22 1741 92870 1079172 78570605
Nocardiosis 73.61 11.22 58 94553 5621 79644156
Cardiac arrest 73.37 11.22 400 94211 171696 79478081
Drug resistance 72.53 11.22 157 94454 42056 79607721
Disseminated intravascular coagulation 71.79 11.22 142 94469 35700 79614077
Anxiety 70.80 11.22 116 94495 248396 79401381
Altered state of consciousness 70.79 11.22 159 94452 43663 79606114
Weight decreased 70.40 11.22 203 94408 354995 79294782
Hypertension 69.44 11.22 184 94427 330808 79318969
Enterococcal infection 69.03 11.22 89 94522 15571 79634206
Infusion related reaction 68.88 11.22 104 94507 230133 79419644
Anuria 68.27 11.22 103 94508 20860 79628917
Toxic skin eruption 67.63 11.22 106 94505 22187 79627590
Intentional overdose 67.19 11.22 21 94590 105939 79543838
Respiratory distress 67.15 11.22 186 94425 58153 79591624
Urticaria 66.92 11.22 412 94199 184789 79464988
Lower respiratory tract infection 66.69 11.22 35 94576 129185 79520592
Product use in unapproved indication 66.26 11.22 516 94095 249843 79399934
Hypoaesthesia 66.19 11.22 69 94542 179283 79470494
Pneumococcal infection 66.08 11.22 29 94582 929 79648848
Brain abscess 65.25 11.22 51 94560 4885 79644892
Haemophagocytic lymphohistiocytosis 65.10 11.22 103 94508 21734 79628043
Ear pruritus 64.33 11.22 47 94564 4068 79645709
Migraine 63.84 11.22 13 94598 87480 79562297
Torsade de pointes 63.05 11.22 95 94516 19217 79630560
Myasthenia gravis crisis 61.96 11.22 29 94582 1082 79648695
Musculoskeletal pain 61.90 11.22 22 94589 102332 79547445
Trichosporon infection 61.49 11.22 28 94583 980 79648797
Myocardial infarction 61.27 11.22 77 94534 184052 79465725
Helicobacter infection 60.99 11.22 6 94605 69698 79580079
Mucormycosis 60.89 11.22 62 94549 8407 79641370
Erythema 60.62 11.22 463 94148 222827 79426950
Injection site erythema 60.54 11.22 10 94601 78187 79571590
COVID-19 pneumonia 59.85 11.22 116 94495 28733 79621044
Condition aggravated 59.65 11.22 879 93732 500245 79149532
Abdominal pain upper 59.62 11.22 109 94502 223710 79426067
Inappropriate schedule of product administration 59.50 11.22 43 94568 133585 79516192
Shock 59.47 11.22 148 94463 43400 79606377
Feeling abnormal 59.02 11.22 61 94550 159138 79490639
Hyponatraemia 58.90 11.22 387 94224 177461 79472316
Pericarditis 58.75 11.22 25 94586 104211 79545566
Blood pressure fluctuation 58.18 11.22 6 94605 67139 79582638
Stomatitis 58.15 11.22 53 94558 146704 79503073
Osteoarthritis 57.74 11.22 16 94595 87293 79562484
Pulmonary function test abnormal 57.35 11.22 44 94567 4100 79645677
Hepatic cytolysis 57.34 11.22 110 94501 27041 79622736
Back pain 57.26 11.22 178 94433 304002 79345775
Chest X-ray abnormal 57.20 11.22 58 94553 7825 79641952
Blood pressure increased 57.13 11.22 102 94509 211258 79438519
Ill-defined disorder 56.78 11.22 6 94605 65869 79583908
Stenotrophomonas infection 56.52 11.22 42 94569 3731 79646046
Linear IgA disease 56.41 11.22 39 94572 3093 79646684
Haemodynamic instability 56.03 11.22 85 94526 17297 79632480
Blood lactic acid increased 55.50 11.22 72 94539 12672 79637105
Cholangitis 55.36 11.22 72 94539 12704 79637073
Balance disorder 55.26 11.22 24 94587 98833 79550944
Fibromyalgia 55.10 11.22 6 94605 64334 79585443
Psoriatic arthropathy 54.06 11.22 13 94598 77986 79571791
Enterobacter infection 53.62 11.22 44 94567 4518 79645259
Nausea 52.50 11.22 810 93801 956386 78693391
Inflammatory marker increased 52.05 11.22 64 94547 10676 79639101
Cyanosis 51.93 11.22 101 94510 25081 79624696
Psoriasis 51.27 11.22 21 94590 89566 79560211
Folliculitis 50.53 11.22 4 94607 55376 79594401
Dermatitis exfoliative generalised 50.23 11.22 52 94559 7189 79642588
Hepatitis acute 50.09 11.22 76 94535 15466 79634311
Injection site reaction 49.87 11.22 4 94607 54781 79594996
Memory impairment 49.69 11.22 36 94575 111698 79538079
Escherichia infection 49.64 11.22 82 94529 17935 79631842
Hospitalisation 49.40 11.22 25 94586 94211 79555566
Dermatitis bullous 49.27 11.22 72 94539 14173 79635604
Hepatic function abnormal 48.97 11.22 194 94417 72913 79576864
Arthritis 48.55 11.22 39 94572 114841 79534936
Jaundice 48.06 11.22 156 94455 53193 79596584
Endocarditis 47.93 11.22 61 94550 10536 79639241
Intervertebral discitis 47.41 11.22 42 94569 4786 79644991
Pancytopenia 47.41 11.22 348 94263 165397 79484380
Oliguria 47.34 11.22 76 94535 16233 79633544
Dyspepsia 47.06 11.22 36 94575 108651 79541126
Neurotoxicity 47.05 11.22 113 94498 32405 79617372
Dermatitis exfoliative 46.88 11.22 61 94550 10768 79639009
Palpitations 46.38 11.22 49 94562 126561 79523216
Symmetrical drug-related intertriginous and flexural exanthema 45.96 11.22 22 94589 864 79648913
Bile duct stone 45.91 11.22 44 94567 5545 79644232
Cataract 45.80 11.22 9 94602 62111 79587666
Leukopenia 45.78 11.22 265 94346 116248 79533529
C-reactive protein abnormal 45.55 11.22 3 94608 48364 79601413
Aspartate aminotransferase increased 45.47 11.22 301 94310 138340 79511437
Candida infection 45.13 11.22 123 94488 38091 79611686
Renal failure 45.00 11.22 399 94212 200569 79449208
Type 2 diabetes mellitus 44.90 11.22 7 94604 57115 79592662
Acute respiratory failure 44.82 11.22 164 94447 59377 79590400
Myasthenia gravis 44.12 11.22 58 94553 10341 79639436
Acinetobacter infection 44.05 11.22 32 94579 2745 79647032
Aspergillus infection 43.41 11.22 80 94531 19081 79630696
Type IV hypersensitivity reaction 43.09 11.22 37 94574 4044 79645733
Fixed eruption 42.28 11.22 32 94579 2922 79646855
Metabolic acidosis 42.26 11.22 202 94409 82327 79567450
Cholecystitis 42.09 11.22 86 94525 22126 79627651
Drug eruption 41.88 11.22 131 94480 43804 79605973
Acute hepatic failure 41.81 11.22 103 94508 30010 79619767
Platelet count increased 41.57 11.22 86 94525 22320 79627457
Nosocomial infection 41.25 11.22 31 94580 2801 79646976
Gastrooesophageal reflux disease 40.88 11.22 38 94573 104208 79545569
Asthenia 40.85 11.22 399 94212 511290 79138487
Disseminated cryptococcosis 40.68 11.22 26 94585 1808 79647969
Blood glucose increased 40.45 11.22 46 94565 114929 79534848
Road traffic accident 40.27 11.22 3 94608 43661 79606116
SJS-TEN overlap 39.84 11.22 19 94592 740 79649037
Gastrointestinal disorder 39.71 11.22 52 94559 122153 79527624
Hepatitis fulminant 39.68 11.22 46 94565 7216 79642561
International normalised ratio increased 39.56 11.22 202 94409 84519 79565258
Therapeutic product effect incomplete 39.49 11.22 67 94544 141578 79508199
Suicidal ideation 38.90 11.22 21 94590 76319 79573458
Vision blurred 38.76 11.22 41 94570 105857 79543920
Hypofibrinogenaemia 38.60 11.22 26 94585 1976 79647801
Liver function test increased 38.29 11.22 119 94492 39654 79610123
Influenza B virus test positive 37.95 11.22 15 94596 367 79649410
Procalcitonin increased 37.46 11.22 30 94581 2976 79646801
Cardiac failure congestive 37.32 11.22 70 94541 142332 79507445
Diarrhoea 37.15 11.22 780 93831 879709 78770068
Bacterial pericarditis 37.05 11.22 10 94601 67 79649710
Hepatomegaly 36.86 11.22 74 94537 18800 79630977
CSF oligoclonal band present 36.53 11.22 15 94596 406 79649371
Unresponsive to stimuli 36.52 11.22 147 94464 55641 79594136
No adverse event 36.47 11.22 112 94499 37080 79612697
Alveolitis 36.42 11.22 34 94577 4146 79645631
Adverse event 36.31 11.22 13 94598 60201 79589576
Renal papillary necrosis 36.23 11.22 15 94596 415 79649362
Systemic candida 35.84 11.22 42 94569 6664 79643113
Tachycardia 35.79 11.22 345 94266 177423 79472354
Hepatitis toxic 35.77 11.22 37 94574 5110 79644667
Bronchopleural fistula 35.65 11.22 17 94594 662 79649115
Morganella infection 35.44 11.22 20 94591 1107 79648670
Erythema multiforme 35.43 11.22 70 94541 17581 79632196
Splenomegaly 35.43 11.22 77 94534 20677 79629100
Loss of personal independence in daily activities 35.05 11.22 42 94569 102538 79547239
Chest pain 34.56 11.22 195 94416 282109 79367668
Alcohol intolerance 34.49 11.22 15 94596 470 79649307
Nasal polyps 34.44 11.22 43 94568 7284 79642493
Injection site swelling 34.39 11.22 7 94604 47125 79602652
Cerebrovascular accident 34.32 11.22 84 94527 155208 79494569
Impaired healing 34.31 11.22 32 94579 87623 79562154
Dry skin 34.22 11.22 19 94592 67976 79581801
Orthostatic hypotension 34.08 11.22 12 94599 56152 79593625
Wrong technique in product usage process 33.90 11.22 23 94588 73852 79575925
Coagulation factor decreased 33.78 11.22 12 94599 216 79649561
Partial seizures 33.43 11.22 47 94564 8931 79640846
Erythema nodosum 33.01 11.22 36 94575 5281 79644496
Crystalluria 32.98 11.22 18 94593 933 79648844
Cryptococcal meningoencephalitis 32.24 11.22 12 94599 248 79649529
Rash erythematous 32.22 11.22 145 94466 57624 79592153
Ureteral disorder 32.09 11.22 15 94596 558 79649219
Influenza like illness 32.01 11.22 23 94588 71684 79578093
Renal tubular necrosis 32.00 11.22 83 94528 24956 79624821
Blood uric acid increased 31.81 11.22 57 94554 13303 79636474
Multiple sclerosis relapse 31.77 11.22 8 94603 46525 79603252
Fluid retention 31.68 11.22 22 94589 69787 79579990
Neutrophilia 31.67 11.22 43 94568 7908 79641869
Hip arthroplasty 31.48 11.22 3 94608 35753 79614024
Drug effective for unapproved indication 31.10 11.22 37 94574 5964 79643813
Product use issue 30.79 11.22 136 94475 209686 79440091
Decreased appetite 30.78 11.22 259 94352 342159 79307618
Coronary artery disease 30.56 11.22 20 94591 65454 79584323
Gamma-glutamyltransferase increased 30.31 11.22 137 94474 54543 79595234
Cholecystitis acute 30.27 11.22 56 94555 13395 79636382
Oropharyngeal pain 30.23 11.22 52 94559 109301 79540476
Intracranial pressure increased 30.15 11.22 43 94568 8279 79641498
Muscle injury 30.11 11.22 10 94601 48551 79601226
Rhinitis allergic 30.05 11.22 53 94558 12216 79637561
Autoimmune haemolytic anaemia 29.92 11.22 43 94568 8337 79641440
Malignant mesenteric neoplasm 29.72 11.22 8 94603 53 79649724
Purpura 29.48 11.22 69 94542 19458 79630319
Hyperphosphataemia 29.30 11.22 37 94574 6339 79643438
Blood pressure systolic increased 29.24 11.22 22 94589 66964 79582813
CSF measles antibody positive 29.21 11.22 8 94603 57 79649720
Visual impairment 29.12 11.22 40 94571 92091 79557686
Vasculitis 28.85 11.22 80 94531 25022 79624755
Herpes zoster 28.84 11.22 41 94570 93042 79556735
Rubella antibody positive 28.74 11.22 8 94603 61 79649716
Sciatica 28.70 11.22 3 94608 33219 79616558
Anti factor V antibody 28.69 11.22 5 94606 0 79649777
Hypercreatininaemia 28.63 11.22 17 94594 1036 79648741
Weber tuning fork test abnormal 28.54 11.22 9 94602 110 79649667
Gastric disorder 28.50 11.22 5 94606 37428 79612349
Pyuria 28.31 11.22 23 94588 2329 79647448
Cholestatic liver injury 28.18 11.22 32 94579 4909 79644868
Neoplasm progression 28.17 11.22 13 94598 51669 79598108
Organic brain syndrome 28.13 11.22 13 94598 471 79649306
Angioedema 27.97 11.22 170 94441 75865 79573912
Portal fibrosis 27.96 11.22 14 94597 607 79649170
Transient ischaemic attack 27.58 11.22 14 94597 52681 79597096
Procalcitonin abnormal 27.53 11.22 12 94599 378 79649399
Sleep apnoea syndrome 27.50 11.22 5 94606 36473 79613304
Nephropathy toxic 27.46 11.22 69 94542 20350 79629427
Systemic inflammatory response syndrome 27.41 11.22 49 94562 11416 79638361
Propofol infusion syndrome 27.32 11.22 21 94590 1962 79647815
Liver injury 27.14 11.22 136 94475 56478 79593299
Coagulopathy 26.94 11.22 99 94512 35907 79613870
Janeway lesion 26.93 11.22 6 94605 15 79649762
Face oedema 26.91 11.22 84 94527 28052 79621725
Device related sepsis 26.78 11.22 35 94576 6205 79643572
Neck pain 26.71 11.22 30 94581 75387 79574390
Analgesic therapy 26.68 11.22 16 94595 993 79648784
Empyema 26.63 11.22 29 94582 4247 79645530
Flank pain 26.63 11.22 67 94544 19777 79630000
Vascular purpura 26.61 11.22 25 94586 3073 79646704
Maternal exposure during pregnancy 26.50 11.22 263 94348 136275 79513502
Nervousness 26.48 11.22 4 94607 33411 79616366
Hyperthermia 26.43 11.22 63 94548 17974 79631803
Cerebral cyst 26.43 11.22 12 94599 417 79649360
Peritoneal dialysis 26.41 11.22 15 94596 841 79648936
Mitochondrial DNA mutation 26.33 11.22 12 94599 421 79649356
Sphincter of Oddi dysfunction 26.33 11.22 12 94599 421 79649356
Hepatitis infectious mononucleosis 26.03 11.22 9 94602 149 79649628
Hip fracture 26.01 11.22 3 94608 30758 79619019
Hepatosplenomegaly 25.98 11.22 34 94577 6035 79643742
Injection site pruritus 25.71 11.22 9 94602 42274 79607503
Pneumonia mycoplasmal 25.67 11.22 18 94593 1460 79648317
Stress 25.58 11.22 172 94439 79440 79570337
Muscle abscess 25.57 11.22 16 94595 1072 79648705
Blood creatinine increased 25.56 11.22 289 94322 154768 79495009
Multiple-drug resistance 25.50 11.22 41 94570 8767 79641010
Pyelonephritis 25.46 11.22 67 94544 20321 79629456
Encephalitis brain stem 25.44 11.22 10 94601 241 79649536
COVID-19 treatment 25.39 11.22 12 94599 458 79649319
Meningitis bacterial 25.31 11.22 23 94588 2709 79647068
Leukaemoid reaction 25.28 11.22 11 94600 345 79649432
Neuropathy peripheral 24.95 11.22 85 94526 141220 79508557
Corynebacterium infection 24.90 11.22 17 94594 1321 79648456
Gait inability 24.89 11.22 20 94591 58897 79590880
Normal newborn 24.83 11.22 36 94575 7036 79642741
Serum sickness-like reaction 24.78 11.22 13 94598 622 79649155
Amnesia 24.70 11.22 23 94588 63034 79586743
Dysgeusia 24.67 11.22 19 94592 57158 79592619
Vascular device infection 24.67 11.22 44 94567 10232 79639545
Localised infection 24.63 11.22 7 94604 37568 79612209
Cheilitis 24.56 11.22 31 94580 5310 79644467
Blood alkaline phosphatase increased 24.47 11.22 144 94467 63520 79586257
Hypokalaemia 24.44 11.22 270 94341 143770 79506007
Basal cell carcinoma 24.43 11.22 7 94604 37368 79612409
Joint stiffness 24.30 11.22 9 94602 40821 79608956
Joint injury 24.27 11.22 4 94607 31331 79618446
Type I hypersensitivity 24.26 11.22 28 94583 4370 79645407
Suicide attempt 24.26 11.22 38 94573 82894 79566883
Drug therapy 24.12 11.22 16 94595 1185 79648592
Sedation 24.02 11.22 16 94595 51879 79597898
Haemostasis 24.00 11.22 11 94600 391 79649386
Mycotic endophthalmitis 23.87 11.22 9 94602 193 79649584
Chorioretinitis 23.70 11.22 15 94596 1025 79648752
Jejunal ulcer perforation 23.68 11.22 8 94603 123 79649654
Breath sounds abnormal 23.61 11.22 56 94555 15928 79633849
Pneumonia bacterial 23.60 11.22 63 94548 19268 79630509
Granulomatous dermatitis 23.51 11.22 11 94600 410 79649367
Ureteric obstruction 23.49 11.22 22 94589 2694 79647083
Lip oedema 23.42 11.22 33 94578 6283 79643494
Brain herniation 23.35 11.22 36 94575 7427 79642350
Hyperbilirubinaemia 23.27 11.22 73 94538 24445 79625332
Intentional self-injury 23.27 11.22 5 94606 32414 79617363
Staphylococcal infection 23.15 11.22 133 94478 58162 79591615
Pruritus 22.99 11.22 622 93989 394026 79255751
Myopathy toxic 22.96 11.22 15 94596 1083 79648694
Hyperferritinaemia 22.93 11.22 13 94598 726 79649051
Bursitis 22.90 11.22 7 94604 35837 79613940
Influenza 22.86 11.22 78 94533 129528 79520249
Cholangitis acute 22.83 11.22 17 94594 1515 79648262
Lymphadenopathy 22.82 11.22 124 94487 53123 79596654
Heart rate decreased 22.76 11.22 30 94581 70286 79579491
Dyspnoea exertional 22.64 11.22 43 94568 87030 79562747
Drug dependence 22.61 11.22 10 94601 40759 79609018
Otitis media acute 22.57 11.22 16 94595 1321 79648456
Infection 22.54 11.22 181 94430 241531 79408246
Blood brain barrier defect 22.52 11.22 8 94603 144 79649633
Pancreatitis acute 22.27 11.22 117 94494 49487 79600290
Bacterial parotitis 22.13 11.22 6 94605 41 79649736
Interleukin-2 receptor increased 22.01 11.22 9 94602 241 79649536
Pelvic inflammatory disease 21.99 11.22 16 94595 1376 79648401
Factor V deficiency 21.94 11.22 7 94604 89 79649688
Rash 21.68 11.22 865 93746 577493 79072284
Pain in jaw 21.67 11.22 14 94597 46137 79603640
Surgery 21.67 11.22 6 94605 32760 79617017
Omental necrosis 21.64 11.22 6 94605 45 79649732
Mixed liver injury 21.57 11.22 35 94576 7543 79642234
Acquired haemophilia 21.56 11.22 18 94593 1893 79647884
Paraesthesia 21.45 11.22 122 94489 176201 79473576
Sleep disorder therapy 21.44 11.22 14 94597 1010 79648767
Calculus urinary 21.41 11.22 20 94591 2440 79647337
Hyperpyrexia 21.37 11.22 31 94580 6061 79643716
Muscular weakness 21.33 11.22 108 94503 160621 79489156
Tooth disorder 21.11 11.22 3 94608 26230 79623547
Abdominal distension 21.09 11.22 226 94385 119424 79530353
Eastern Cooperative Oncology Group performance status 21.09 11.22 6 94605 50 79649727
Bronchospasm 20.88 11.22 71 94540 24788 79624989
Fibrin D dimer increased 20.70 11.22 37 94574 8617 79641160
Antinuclear antibody negative 20.67 11.22 5 94606 20 79649757
Laryngeal stenosis 20.66 11.22 14 94597 1074 79648703
Encephalitis autoimmune 20.64 11.22 19 94592 2275 79647502
Cardiac ventricular thrombosis 20.63 11.22 17 94594 1756 79648021
Generalised bullous fixed drug eruption 20.58 11.22 8 94603 187 79649590
Cryptococcosis 20.56 11.22 23 94588 3470 79646307
Vitamin K deficiency 20.44 11.22 12 94599 716 79649061
Gastroenteritis clostridial 20.20 11.22 13 94598 915 79648862
Strongyloidiasis 20.15 11.22 24 94587 3874 79645903
Pulmonary physical examination abnormal 20.10 11.22 5 94606 23 79649754
Liver transplant failure 20.02 11.22 7 94604 120 79649657
Hyperamylasaemia 20.00 11.22 14 94597 1133 79648644
Ear pain 19.98 11.22 7 94604 32862 79616915
Hypoalbuminaemia 19.83 11.22 63 94548 21234 79628543
Stress cardiomyopathy 19.71 11.22 42 94569 11124 79638653
Blood gases abnormal 19.64 11.22 14 94597 1166 79648611
Upper-airway cough syndrome 19.52 11.22 43 94568 11650 79638127
Cerebellar syndrome 19.39 11.22 28 94583 5452 79644325
CSF protein increased 19.01 11.22 14 94597 1226 79648551
Encephalomalacia 19.00 11.22 14 94597 1227 79648550
Infective chondritis 19.00 11.22 5 94606 30 79649747
Hyperlactacidaemia 18.94 11.22 28 94583 5567 79644210
Pneumothorax 18.83 11.22 75 94536 28248 79621529
Lymphopenia 18.80 11.22 79 94532 30478 79619299
Dehydration 18.73 11.22 196 94415 247991 79401786
Urinary tract infection fungal 18.70 11.22 13 94598 1040 79648737
Flatulence 18.68 11.22 14 94597 42710 79607067
Normocytic anaemia 18.68 11.22 24 94587 4183 79645594
Injury 18.67 11.22 40 94571 77456 79572321
Hypernatraemia 18.57 11.22 48 94563 14403 79635374
Vanishing bile duct syndrome 18.53 11.22 16 94595 1762 79648015
Endocarditis bacterial 18.50 11.22 15 94596 1514 79648263
Iris transillumination defect 18.49 11.22 7 94604 152 79649625
Antibiotic level below therapeutic 18.48 11.22 6 94605 81 79649696
Petechiae 18.39 11.22 60 94551 20505 79629272
Macule 18.32 11.22 20 94591 2937 79646840
Coombs negative haemolytic anaemia 18.26 11.22 9 94602 377 79649400
Antibiotic associated colitis 18.25 11.22 4 94607 9 79649768
Hypertriglyceridaemia 18.13 11.22 44 94567 12696 79637081
Sneezing 18.12 11.22 58 94553 19625 79630152
Hypovolaemic shock 18.12 11.22 43 94568 12233 79637544
Type IIa hyperlipidaemia 18.09 11.22 8 94603 261 79649516
Cell death 18.09 11.22 25 94586 4674 79645103
Head injury 18.01 11.22 11 94600 37358 79612419
Bone marrow failure 17.99 11.22 113 94498 50994 79598783
Postpartum sepsis 17.95 11.22 4 94607 10 79649767
Pneumonia pneumococcal 17.88 11.22 23 94588 4014 79645763
Syncope 17.84 11.22 132 94479 179317 79470460
Malabsorption from administration site 17.83 11.22 7 94604 168 79649609
Prothrombin time ratio decreased 17.80 11.22 12 94599 913 79648864
Hypocoagulable state 17.74 11.22 17 94594 2142 79647635
Relapsing fever 17.65 11.22 9 94602 406 79649371
Overdose 17.60 11.22 137 94474 184069 79465708
Depressed mood 17.48 11.22 19 94592 48461 79601316
Metastases to stomach 17.46 11.22 8 94603 284 79649493
Skin test positive 17.43 11.22 13 94598 1161 79648616
Blood pressure diastolic decreased 17.42 11.22 7 94604 30209 79619568
Pneumococcal sepsis 17.41 11.22 15 94596 1647 79648130
Pyelonephritis acute 17.39 11.22 28 94583 5995 79643782
Osteomyelitis fungal 17.31 11.22 8 94603 290 79649487
Bacteraemia 17.27 11.22 81 94530 32743 79617034
Renal impairment 17.24 11.22 273 94338 157510 79492267
Megacolon 17.22 11.22 21 94590 3474 79646303
Red blood cell agglutination 17.21 11.22 3 94608 0 79649777
Joint range of motion decreased 17.18 11.22 9 94602 33273 79616504
Veillonella infection 17.13 11.22 5 94606 46 79649731
Prescribed overdose 17.11 11.22 12 94599 37871 79611906
Sinus disorder 17.10 11.22 3 94608 22461 79627316
Hypersensitivity vasculitis 17.02 11.22 30 94581 6913 79642864
Pneumonia necrotising 16.92 11.22 13 94598 1214 79648563
Accidental exposure to product 16.88 11.22 8 94603 31314 79618463
Injection site haemorrhage 16.83 11.22 6 94605 27864 79621913
Arterial angioplasty 16.76 11.22 5 94606 50 79649727
Dysstasia 16.71 11.22 6 94605 27740 79622037
Osteonecrosis of jaw 16.65 11.22 16 94595 43210 79606567
Cardiac disorder 16.63 11.22 33 94578 65724 79584053
Pollakiuria 16.61 11.22 12 94599 37305 79612472
Tracheobronchitis 16.60 11.22 16 94595 2030 79647747
Foot fracture 16.59 11.22 3 94608 21978 79627799
Carotid artery insufficiency 16.53 11.22 4 94607 16 79649761
Bacteriuria 16.51 11.22 13 94598 1258 79648519
Incorrect dose administered 16.49 11.22 42 94569 76588 79573189
Haemorrhoids 16.39 11.22 7 94604 29121 79620656
Dry eye 16.28 11.22 12 94599 36919 79612858
Foetal death 16.26 11.22 32 94579 8012 79641765
Henoch-Schonlein purpura 16.22 11.22 18 94593 2692 79647085
Guillain-Barre syndrome 16.15 11.22 34 94577 8931 79640846
Septic pulmonary embolism 16.12 11.22 6 94605 124 79649653
Obesity 16.03 11.22 11 94600 35114 79614663
Eosinophilic pneumonia acute 15.95 11.22 12 94599 1086 79648691
Abdominal wall haematoma 15.95 11.22 24 94587 4849 79644928
Delirium 15.92 11.22 162 94449 84465 79565312
Abdominal compartment syndrome 15.90 11.22 14 94597 1583 79648194
Bone pain 15.87 11.22 26 94585 55716 79594061
Lower limb fracture 15.83 11.22 4 94607 23211 79626566
Meningitis aseptic 15.78 11.22 29 94582 6899 79642878
Eosinophilic pneumonia 15.76 11.22 25 94586 5285 79644492
Shock haemorrhagic 15.72 11.22 56 94555 20004 79629773
Blood cholesterol increased 15.72 11.22 49 94562 83671 79566106
Procedural pain 15.70 11.22 4 94607 23080 79626697
Therapeutic response decreased 15.69 11.22 35 94576 66818 79582959
Device related bacteraemia 15.69 11.22 10 94601 692 79649085
Palmar-plantar erythrodysaesthesia syndrome 15.63 11.22 10 94601 33124 79616653
Pulmonary necrosis 15.58 11.22 9 94602 521 79649256
Neuroborreliosis 15.56 11.22 6 94605 137 79649640
Meningism 15.53 11.22 10 94601 704 79649073
Hepatic failure 15.52 11.22 125 94486 61087 79588690
Red blood cell sedimentation rate increased 15.49 11.22 19 94592 45923 79603854
Allergy test positive 15.36 11.22 10 94601 718 79649059
Central nervous system vasculitis 15.35 11.22 13 94598 1395 79648382
Antimicrobial susceptibility test resistant 15.30 11.22 8 94603 380 79649397
Heart rate irregular 15.23 11.22 10 94601 32669 79617108
Limb injury 15.22 11.22 8 94603 29520 79620257
Metastases to bone 15.20 11.22 5 94606 24422 79625355
Endotracheal intubation 15.18 11.22 23 94588 4674 79645103
Ocular icterus 15.11 11.22 25 94586 5475 79644302
Feeling hot 15.09 11.22 30 94581 59704 79590073
Lung consolidation 15.05 11.22 33 94578 8914 79640863
Laryngeal mass 15.04 11.22 5 94606 73 79649704
Malignant neoplasm progression 15.01 11.22 97 94514 135893 79513884
Thunderclap headache 14.98 11.22 8 94603 397 79649380
Multiple sclerosis 14.89 11.22 4 94607 22278 79627499
Drug hypersensitivity 14.88 11.22 462 94149 298454 79351323
Sleep disorder 14.81 11.22 52 94559 85625 79564152
Septic embolus 14.72 11.22 15 94596 2036 79647741
Red blood cell schistocytes present 14.70 11.22 9 94602 580 79649197
Blood fibrinogen increased 14.66 11.22 14 94597 1756 79648021
Gene mutation 14.65 11.22 17 94594 2669 79647108
Diabetes insipidus 14.65 11.22 24 94587 5213 79644564
Meningitis 14.62 11.22 34 94577 9548 79640229
Pneumonia staphylococcal 14.54 11.22 23 94588 4851 79644926
Haemodialysis 14.48 11.22 51 94560 18117 79631660
Grip strength decreased 14.47 11.22 4 94607 21865 79627912
Oral pain 14.45 11.22 10 94601 31788 79617989
Muscle tension dysphonia 14.42 11.22 6 94605 168 79649609
Hypothyroidism 14.40 11.22 25 94586 52367 79597410
Eye pain 14.37 11.22 14 94597 37564 79612213
Hot flush 14.35 11.22 27 94584 54850 79594927
Amniotic cavity infection 14.20 11.22 10 94601 817 79648960
Epistaxis 14.19 11.22 76 94535 111439 79538338
Fungaemia 14.16 11.22 22 94589 4569 79645208
Localised oedema 14.14 11.22 30 94581 7922 79641855
Nephritis 14.14 11.22 21 94590 4193 79645584
Rhinocerebral mucormycosis 14.13 11.22 11 94600 1047 79648730
Vitamin A deficiency 14.13 11.22 5 94606 89 79649688
Psychotic disorder 14.09 11.22 17 94594 41385 79608392
Embolia cutis medicamentosa 14.06 11.22 9 94602 627 79649150
Dysmetria 14.01 11.22 11 94600 1060 79648717
Lymphocyte transformation test positive 13.99 11.22 4 94607 34 79649743
Unevaluable event 13.97 11.22 28 94583 55557 79594220
Rash pustular 13.95 11.22 37 94574 11274 79638503
Post treatment Lyme disease syndrome 13.93 11.22 3 94608 6 79649771
Illness 13.90 11.22 21 94590 46490 79603287
Pancreatitis necrotising 13.87 11.22 20 94591 3888 79645889
ADAMTS13 activity decreased 13.85 11.22 6 94605 186 79649591
Myalgia 13.84 11.22 147 94464 185494 79464283
Prescribed underdose 13.79 11.22 9 94602 29505 79620272
Cardiac valve abscess 13.78 11.22 4 94607 36 79649741
Glycosylated haemoglobin increased 13.76 11.22 3 94608 19257 79630520
Fungal peritonitis 13.75 11.22 11 94600 1089 79648688
Necrosis 13.74 11.22 33 94578 9460 79640317
Idiosyncratic drug reaction 13.72 11.22 12 94599 1345 79648432
Haematuria traumatic 13.71 11.22 6 94605 191 79649586
Transverse sinus thrombosis 13.70 11.22 9 94602 656 79649121
Hypotension 13.67 11.22 646 93965 439671 79210106
Pseudomonas infection 13.61 11.22 55 94556 20848 79628929
Listeriosis 13.56 11.22 15 94596 2235 79647542
Pseudophaeochromocytoma 13.54 11.22 5 94606 101 79649676
Tubulointerstitial nephritis and uveitis syndrome 13.48 11.22 7 94604 328 79649449
Agitation 13.45 11.22 179 94432 99536 79550241
Confabulation 13.44 11.22 8 94603 490 79649287
POEMS syndrome 13.41 11.22 4 94607 40 79649737
Staphylococcus test positive 13.37 11.22 26 94585 6455 79643322
Panic attack 13.34 11.22 6 94605 24210 79625567
Tooth infection 13.32 11.22 3 94608 18829 79630948
PO2 decreased 13.31 11.22 17 94594 2946 79646831
Infective spondylitis 13.20 11.22 8 94603 506 79649271
Prostate cancer 13.19 11.22 12 94599 33256 79616521
Respiratory acidosis 13.17 11.22 36 94575 11164 79638613
Intentional product misuse 13.16 11.22 63 94548 95102 79554675
Clostridial infection 13.12 11.22 24 94587 5690 79644087
Lung abscess 13.10 11.22 20 94591 4092 79645685
Hemianopia 13.06 11.22 13 94598 1715 79648062
Histoplasmosis disseminated 13.01 11.22 15 94596 2338 79647439
Anoxia 12.99 11.22 7 94604 354 79649423
Ischaemic limb pain 12.98 11.22 4 94607 45 79649732
Osteoporosis 12.97 11.22 28 94583 54084 79595693
Multisystem inflammatory syndrome in children 12.90 11.22 4 94607 46 79649731
White blood cell count decreased 12.89 11.22 152 94459 188136 79461641
Acidosis 12.87 11.22 52 94559 19710 79630067
Blood lactate dehydrogenase increased 12.80 11.22 85 94526 39085 79610692
Pneumonia streptococcal 12.73 11.22 16 94595 2729 79647048
Bronchial obstruction 12.62 11.22 16 94595 2752 79647025
Dry gangrene 12.60 11.22 10 94601 979 79648798
Toxic shock syndrome 12.53 11.22 11 94600 1238 79648539
Pleural effusion 12.52 11.22 242 94369 145020 79504757
Hepatic necrosis 12.50 11.22 31 94580 9069 79640708
Hyper IgE syndrome 12.43 11.22 8 94603 563 79649214
Injection site rash 12.42 11.22 3 94608 17951 79631826
Glaucoma 12.37 11.22 4 94607 19757 79630020
Blood potassium decreased 12.35 11.22 96 94515 46416 79603361
Haemoglobinuria 12.29 11.22 9 94602 782 79648995
Haemoperitoneum 12.28 11.22 20 94591 4323 79645454
Heparin-induced thrombocytopenia 12.27 11.22 32 94579 9650 79640127
Haemorrhoids thrombosed 12.27 11.22 6 94605 247 79649530
Body temperature decreased 12.27 11.22 12 94599 32133 79617644
Tuberculosis of genitourinary system 12.25 11.22 4 94607 55 79649722
Pulmonary function test 12.21 11.22 3 94608 13 79649764
Abdominal pain 12.18 11.22 572 94039 388997 79260780
Meningitis candida 12.05 11.22 5 94606 139 79649638
Conjunctival hyperaemia 12.04 11.22 20 94591 4393 79645384
Chondrocalcinosis 12.03 11.22 10 94601 1046 79648731
Neoplasm malignant 11.99 11.22 12 94599 31798 79617979
Femur fracture 11.99 11.22 17 94594 38635 79611142
Arthritis reactive 11.90 11.22 8 94603 606 79649171
Intravascular haemolysis 11.90 11.22 9 94602 821 79648956
Expired product administered 11.85 11.22 26 94585 7025 79642752
Anticonvulsant drug level below therapeutic 11.82 11.22 10 94601 1071 79648706
Osteomyelitis 11.78 11.22 73 94538 32792 79616985
Acne 11.77 11.22 9 94602 27181 79622596
Hyperkalaemia 11.77 11.22 196 94415 114202 79535575
Throat irritation 11.75 11.22 19 94592 40927 79608850
Mechanical urticaria 11.71 11.22 7 94604 432 79649345
Coagulation factor V level decreased 11.70 11.22 8 94603 623 79649154
Urine potassium increased 11.70 11.22 3 94608 16 79649761
Periostosis 11.70 11.22 3 94608 16 79649761
Upper respiratory tract infection 11.67 11.22 62 94549 91106 79558671
Gastrointestinal mucormycosis 11.66 11.22 7 94604 435 79649342
Wound infection 11.65 11.22 7 94604 23984 79625793
Haematochezia 11.56 11.22 59 94552 87586 79562191
Neuralgic amyotrophy 11.50 11.22 6 94605 284 79649493
Normochromic anaemia 11.42 11.22 7 94604 452 79649325
Metastases to heart 11.40 11.22 6 94605 289 79649488
Alpha 1 microglobulin increased 11.36 11.22 4 94607 70 79649707
CD4 lymphocytes increased 11.34 11.22 6 94605 292 79649485
Tenderness 11.34 11.22 7 94604 23635 79626142
Tetany 11.24 11.22 15 94596 2713 79647064

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01DD04 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Third-generation cephalosporins
ATC J01DD54 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Third-generation cephalosporins
ATC J01DD63 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Third-generation cephalosporins
FDA CS M0003827 Cephalosporins
FDA EPC N0000175488 Cephalosporin Antibacterial
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:35625 beta-lactamase inhibitors
CHEBI has role CHEBI:36047 antibacterial drugs
CHEBI has role CHEBI:88188 allergenic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Gonococcal meningitis indication 151004
Streptococcal meningitis indication 4510004 DOID:11574
Septicemia due to Escherichia coli indication 9323009
Bacterial septicemia indication 10001005 DOID:0040085
Staphylococcal meningitis indication 12166008
Gonorrhea indication 15628003 DOID:7551
Infection of skin AND/OR subcutaneous tissue indication 19824006
Acute gonococcal cervicitis indication 20943002 DOID:10615
Staphylococcal pneumonia indication 22754005
Streptococcal septicemia indication 29577008
Acute gonococcal urethritis indication 29864006
Pneumonia due to Streptococcus indication 34020007
Gonorrhea of rectum indication 42746002
Gonococcal infection of joint indication 44743006
Bacterial arthritis indication 48245008
Salmonella septicemia indication 49786009
Lower respiratory tract infection indication 50417007
Pneumococcal meningitis indication 51169003
Pneumonia due to Escherichia coli indication 51530003
Bacterial pneumonia indication 53084003 DOID:874
Klebsiella cystitis indication 60867007
Gonococcal endocarditis indication 61048000
Acute gonococcal endometritis indication 65295003 DOID:7527
Haemophilus influenzae pneumonia indication 70036007
Infection due to Escherichia coli indication 71057007
Bacterial infection due to Serratia indication 71120004
Rhinoscleroma indication 72409005 DOID:11336
Gonorrhea of pharynx indication 74372003
Endometritis indication 78623009 DOID:1002
Bacterial meningitis indication 95883001 DOID:9470
Infection of bone indication 111253001
Staphylococcal septicemia indication 111821004
Female genital tract infection indication 125585007
Infectious disease of abdomen indication 128070006
Infection due to Enterobacteriaceae indication 128945009
Bacterial infection due to Klebsiella pneumoniae indication 186435004
Meningococcal meningitis indication 192644005
Escherichia coli meningitis indication 192655005
Proteus pneumonia indication 195888009
Chancroid indication 266143009 DOID:13778
Escherichia coli urinary tract infection indication 301011002
Proteus urinary tract infection indication 301012009
Streptococcus pyogenes infection indication 302809008
Bacterial urinary infection indication 312124009
Infective otitis media indication 312218008
Infectious disorder of joint indication 363162000
Meningitis due to Klebsiella mobilis indication 420585007
Peptostreptococcus infection indication 135341000119101
Klebsiella Pneumoniae Osteomyelitis indication
Inflammatory Disease of Female Pelvic Organs indication
Proteus Mirabilis Osteomyelitis indication
Peptostreptococcus Peritonitis indication
Enterobacter Pneumonia indication
Proteus Joint Infection indication
Haemophilus Septic Arthritis indication
Skin and Skin Structure Serratia Infection indication
E. Coli Peritonitis indication
Prevention of Perioperative Infection indication
Haemophilus Influenzae Type B Infections indication
Adult Gonococcal Conjunctivitis indication
E. Coli Septic Arthritis indication
Haemophilus Septicemia indication
Disseminated Gonococcal Infection indication
Klebsiella Pneumoniae Peritonitis indication
H. Influenzae Meningitis indication
Prevention of Meningococcal Meningitis indication
Gram-Negative Aerobic Bacillary Pneumonia indication
Skin and Skin Structure Proteus Infection indication
Haemophilus Osteomyelitis indication
Haemophilus Parainfluenzae Pneumonia indication
Enterobacter Osteomyelitis indication
Streptococcal Joint Infection indication
Pelvic Inflammatory Disease with Neisseria Gonorrhea indication
Klebsiella Joint Infection indication
EnterobacterJoint Infection indication
Skin and Skin Structure Morganella Morganii Infection indication
Streptococcus Osteomyelitis indication
E. Coli Joint Infection indication
E. Coli Osteomyelitis indication
Pyrexia of unknown origin off-label use 7520000
Lyme disease off-label use 23502006 DOID:11729
Lyme arthritis off-label use 33937009
Pseudotuberculosis off-label use 36753006
Lyme carditis off-label use 77863005
Infection by Yersinia enterocolitica off-label use 80960004
Ventilator-acquired pneumonia off-label use 429271009
Lyme Disease of the Central Nervous System off-label use
Sexual Transmitted Disease Exposure from Sexual Assault off-label use
Disorder of gallbladder contraindication 39621005 DOID:0060262
Acute nephropathy contraindication 58574008
Hemolytic anemia contraindication 61261009 DOID:583
Disease of liver contraindication 235856003 DOID:409
Neonatal hyperbilirubinemia contraindication 281610001
Pseudomembranous enterocolitis contraindication 397683000




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.65 acidic
pKa2 4.17 acidic
pKa3 13.31 acidic
pKa4 3.29 Basic
pKa5 0.93 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D-amino-acid oxidase Enzyme IC50 5 CHEMBL
Alpha-synuclein Transporter Kd 6.28 CHEMBL
Peptidoglycan synthase FtsI Enzyme INHIBITOR IC50 6.14 WOMBAT-PK CHEMBL
Penicillin-binding protein 1A Enzyme INHIBITOR IC50 6.51 WOMBAT-PK CHEMBL
Penicillin-binding protein 1B Enzyme INHIBITOR IC50 5.74 WOMBAT-PK CHEMBL
Penicillin-binding protein 2 Enzyme INHIBITOR IC50 6.21 WOMBAT-PK CHEMBL

External reference:

IDSource
4019667 VUID
N0000147759 NUI
D00924 KEGG_DRUG
104376-79-6 SECONDARY_CAS_RN
203172 RXNORM
C0007561 UMLSCUI
CHEBI:29007 CHEBI
9F2 PDB_CHEM_ID
CHEMBL1200995 ChEMBL_ID
CHEMBL161 ChEMBL_ID
CHEMBL3183968 ChEMBL_ID
D002443 MESH_DESCRIPTOR_UI
DB01212 DRUGBANK_ID
5326 IUPHAR_LIGAND_ID
4923 INN_ID
75J73V1629 UNII
5479530 PUBCHEM_CID
1314 MMSL
4387 MMSL
69782 MMSL
d00052 MMSL
002734 NDDF
004849 NDDF
19841008 SNOMEDCT_US
33440000 SNOMEDCT_US
372670001 SNOMEDCT_US
4017814 VANDF
4019667 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9678 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 26 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9678 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 26 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9768 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 23 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9856 INJECTION, POWDER, FOR SOLUTION 2 g INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9856 INJECTION, POWDER, FOR SOLUTION 2 g INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9856 INJECTION, POWDER, FOR SOLUTION 2 g INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9857 INJECTION, POWDER, FOR SOLUTION 1 g INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9857 INJECTION, POWDER, FOR SOLUTION 1 g INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9857 INJECTION, POWDER, FOR SOLUTION 1 g INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9858 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9858 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9858 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9859 INJECTION, POWDER, FOR SOLUTION 250 mg INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9859 INJECTION, POWDER, FOR SOLUTION 250 mg INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9859 INJECTION, POWDER, FOR SOLUTION 250 mg INTRAMUSCULAR ANDA 24 sections
CEFTRIAXONE AND DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0264-3153 INJECTION, SOLUTION 1 g INTRAVENOUS NDA 27 sections
CEFTRIAXONE AND DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0264-3155 INJECTION, SOLUTION 2 g INTRAVENOUS NDA 27 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0338-5002 INJECTION, SOLUTION 1 g INTRAVENOUS ANDA 23 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0338-5002 INJECTION, SOLUTION 1 g INTRAVENOUS ANDA 23 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0338-5003 INJECTION, SOLUTION 2 g INTRAVENOUS ANDA 23 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0338-5003 INJECTION, SOLUTION 2 g INTRAVENOUS ANDA 23 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7332 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7332 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7332 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7332 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7333 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 21 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7333 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 21 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7333 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 21 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7333 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 21 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7334 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 25 sections