Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, cefalosporanic acid derivatives | 564 | 73384-59-5 |
Dose | Unit | Route |
---|---|---|
2 | g | P |
2 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 400 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 46 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 120.27 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 0 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.12 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.22 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.10 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 7.60 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 21, 1984 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug reaction with eosinophilia and systemic symptoms | 736.10 | 12.38 | 403 | 47480 | 33433 | 63407706 |
Acute generalised exanthematous pustulosis | 405.71 | 12.38 | 188 | 47695 | 10911 | 63430228 |
Toxic epidermal necrolysis | 389.50 | 12.38 | 241 | 47642 | 25093 | 63416046 |
Acute kidney injury | 356.58 | 12.38 | 679 | 47204 | 262736 | 63178403 |
Eosinophilia | 338.50 | 12.38 | 212 | 47671 | 22544 | 63418595 |
Pseudocholelithiasis | 328.64 | 12.38 | 54 | 47829 | 6 | 63441133 |
Rash maculo-papular | 291.37 | 12.38 | 220 | 47663 | 31676 | 63409463 |
Fatigue | 244.07 | 12.38 | 189 | 47694 | 887839 | 62553300 |
Multiple organ dysfunction syndrome | 238.02 | 12.38 | 252 | 47631 | 56500 | 63384639 |
Pain | 214.45 | 12.38 | 149 | 47734 | 740479 | 62700660 |
Jarisch-Herxheimer reaction | 208.79 | 12.38 | 50 | 47833 | 327 | 63440812 |
Off label use | 206.08 | 12.38 | 1027 | 46856 | 673435 | 62767704 |
Joint swelling | 205.64 | 12.38 | 10 | 47873 | 327656 | 63113483 |
Premature delivery | 184.34 | 12.38 | 165 | 47718 | 30116 | 63411023 |
Septic shock | 182.77 | 12.38 | 238 | 47645 | 66391 | 63374748 |
Agranulocytosis | 181.49 | 12.38 | 151 | 47732 | 24983 | 63416156 |
Clostridium difficile colitis | 179.28 | 12.38 | 138 | 47745 | 20431 | 63420708 |
Stevens-Johnson syndrome | 176.23 | 12.38 | 148 | 47735 | 24802 | 63416337 |
Alopecia | 167.53 | 12.38 | 27 | 47856 | 337509 | 63103630 |
Cholestasis | 166.66 | 12.38 | 154 | 47729 | 29280 | 63411859 |
Cholelithiasis | 163.13 | 12.38 | 183 | 47700 | 43742 | 63397397 |
Drug interaction | 159.14 | 12.38 | 455 | 47428 | 228676 | 63212463 |
Rheumatoid arthritis | 158.38 | 12.38 | 8 | 47875 | 253811 | 63187328 |
Arthropathy | 158.23 | 12.38 | 4 | 47879 | 234788 | 63206351 |
Arthralgia | 157.62 | 12.38 | 120 | 47763 | 569590 | 62871549 |
Drug intolerance | 154.72 | 12.38 | 24 | 47859 | 308637 | 63132502 |
Electrocardiogram QT prolonged | 153.01 | 12.38 | 206 | 47677 | 59324 | 63381815 |
Pyrexia | 152.21 | 12.38 | 729 | 47154 | 469749 | 62971390 |
Recalled product administered | 145.03 | 12.38 | 40 | 47843 | 485 | 63440654 |
Haemolytic anaemia | 144.69 | 12.38 | 92 | 47791 | 10033 | 63431106 |
Hepatitis | 139.66 | 12.38 | 161 | 47722 | 39627 | 63401512 |
Clostridium test positive | 138.45 | 12.38 | 61 | 47822 | 3140 | 63437999 |
Abdominal discomfort | 135.96 | 12.38 | 37 | 47846 | 320848 | 63120291 |
Status epilepticus | 134.49 | 12.38 | 103 | 47780 | 15130 | 63426009 |
Factor V inhibition | 127.36 | 12.38 | 29 | 47854 | 147 | 63440992 |
Anaphylactic shock | 126.77 | 12.38 | 120 | 47763 | 23513 | 63417626 |
Tubulointerstitial nephritis | 126.19 | 12.38 | 111 | 47772 | 19792 | 63421347 |
Therapeutic product effect decreased | 120.77 | 12.38 | 6 | 47877 | 193181 | 63247958 |
Glossodynia | 120.67 | 12.38 | 3 | 47880 | 178873 | 63262266 |
Pemphigus | 120.57 | 12.38 | 4 | 47879 | 183722 | 63257417 |
Swelling | 119.97 | 12.38 | 30 | 47853 | 275348 | 63165791 |
Headache | 118.99 | 12.38 | 184 | 47699 | 633057 | 62808082 |
Contraindicated product administered | 113.49 | 12.38 | 15 | 47868 | 217633 | 63223506 |
Hepatocellular injury | 110.17 | 12.38 | 119 | 47764 | 27262 | 63413877 |
Systemic lupus erythematosus | 109.89 | 12.38 | 14 | 47869 | 208904 | 63232235 |
Leukocytosis | 106.60 | 12.38 | 114 | 47769 | 25821 | 63415318 |
Pulmonary function test abnormal | 106.28 | 12.38 | 43 | 47840 | 1787 | 63439352 |
Blood lactic acid increased | 105.28 | 12.38 | 66 | 47817 | 7020 | 63434119 |
Weight increased | 103.29 | 12.38 | 34 | 47849 | 260758 | 63180381 |
Encephalopathy | 102.82 | 12.38 | 136 | 47747 | 38484 | 63402655 |
Exposure during pregnancy | 100.29 | 12.38 | 301 | 47582 | 155246 | 63285893 |
Drug ineffective for unapproved indication | 96.99 | 12.38 | 124 | 47759 | 33939 | 63407200 |
Clostridium difficile infection | 96.56 | 12.38 | 116 | 47767 | 29806 | 63411333 |
Wound | 96.20 | 12.38 | 7 | 47876 | 163256 | 63277883 |
Chest X-ray abnormal | 95.54 | 12.38 | 53 | 47830 | 4496 | 63436643 |
Peripheral swelling | 94.75 | 12.38 | 41 | 47842 | 265901 | 63175238 |
Nasopharyngitis | 94.13 | 12.38 | 37 | 47846 | 254220 | 63186919 |
Postrenal failure | 93.71 | 12.38 | 23 | 47860 | 169 | 63440970 |
Respiratory failure | 92.77 | 12.38 | 224 | 47659 | 101634 | 63339505 |
Product dose omission issue | 91.98 | 12.38 | 31 | 47852 | 234282 | 63206857 |
Acute respiratory distress syndrome | 90.70 | 12.38 | 100 | 47783 | 23434 | 63417705 |
Fall | 90.01 | 12.38 | 98 | 47785 | 392236 | 63048903 |
Hepatitis cholestatic | 87.24 | 12.38 | 58 | 47825 | 6820 | 63434319 |
Thrombocytopenia | 86.80 | 12.38 | 281 | 47602 | 150876 | 63290263 |
Pericarditis | 85.84 | 12.38 | 3 | 47880 | 131576 | 63309563 |
Ear pruritus | 85.48 | 12.38 | 47 | 47836 | 3918 | 63437221 |
Cardiac arrest | 84.78 | 12.38 | 204 | 47679 | 92341 | 63348798 |
Drug-induced liver injury | 83.85 | 12.38 | 126 | 47757 | 40096 | 63401043 |
Sepsis | 82.86 | 12.38 | 279 | 47604 | 152844 | 63288295 |
Altered state of consciousness | 81.72 | 12.38 | 98 | 47785 | 25132 | 63416007 |
Pseudomembranous colitis | 81.51 | 12.38 | 42 | 47841 | 3070 | 63438069 |
Transaminases increased | 79.73 | 12.38 | 108 | 47775 | 31259 | 63409880 |
Enterococcal infection | 75.79 | 12.38 | 56 | 47827 | 7792 | 63433347 |
Pain in extremity | 73.59 | 12.38 | 85 | 47798 | 331401 | 63109738 |
Musculoskeletal stiffness | 73.18 | 12.38 | 24 | 47859 | 184594 | 63256545 |
Discomfort | 71.37 | 12.38 | 19 | 47864 | 167355 | 63273784 |
Neutropenia | 71.32 | 12.38 | 291 | 47592 | 174714 | 63266425 |
Anaphylactic reaction | 69.66 | 12.38 | 154 | 47729 | 65946 | 63375193 |
Haemophagocytic lymphohistiocytosis | 68.83 | 12.38 | 60 | 47823 | 10567 | 63430572 |
Toxic encephalopathy | 68.19 | 12.38 | 49 | 47834 | 6530 | 63434609 |
Pleocytosis | 67.38 | 12.38 | 25 | 47858 | 820 | 63440319 |
Linear IgA disease | 67.14 | 12.38 | 29 | 47854 | 1422 | 63439717 |
Dizziness | 67.02 | 12.38 | 140 | 47743 | 429785 | 63011354 |
Contusion | 65.96 | 12.38 | 16 | 47867 | 150028 | 63291111 |
Long QT syndrome | 65.59 | 12.38 | 37 | 47846 | 3242 | 63437897 |
Injection site pain | 65.16 | 12.38 | 10 | 47873 | 129790 | 63311349 |
Insomnia | 65.07 | 12.38 | 41 | 47842 | 215211 | 63225928 |
Bronchopulmonary aspergillosis | 64.65 | 12.38 | 53 | 47830 | 8582 | 63432557 |
Tachypnoea | 62.36 | 12.38 | 71 | 47812 | 17231 | 63423908 |
Dermatitis exfoliative | 62.01 | 12.38 | 43 | 47840 | 5416 | 63435723 |
Pneumococcal infection | 61.65 | 12.38 | 20 | 47863 | 435 | 63440704 |
Acinetobacter infection | 61.54 | 12.38 | 28 | 47855 | 1555 | 63439584 |
Alveolitis | 61.32 | 12.38 | 34 | 47849 | 2881 | 63438258 |
Erythema | 60.68 | 12.38 | 278 | 47605 | 175473 | 63265666 |
Metabolic acidosis | 60.45 | 12.38 | 116 | 47767 | 44953 | 63396186 |
Hypoxia | 60.42 | 12.38 | 137 | 47746 | 59655 | 63381484 |
Low birth weight baby | 60.30 | 12.38 | 47 | 47836 | 7082 | 63434057 |
Choreoathetosis | 58.70 | 12.38 | 20 | 47863 | 509 | 63440630 |
Cholecystitis | 58.66 | 12.38 | 65 | 47818 | 15312 | 63425827 |
Nasal polyps | 58.11 | 12.38 | 43 | 47840 | 5996 | 63435143 |
Urticaria | 57.78 | 12.38 | 263 | 47620 | 165539 | 63275600 |
Helicobacter infection | 57.58 | 12.38 | 3 | 47880 | 92782 | 63348357 |
Tachycardia | 56.72 | 12.38 | 207 | 47676 | 117949 | 63323190 |
Psoriatic arthropathy | 56.66 | 12.38 | 3 | 47880 | 91517 | 63349622 |
Torsade de pointes | 53.65 | 12.38 | 58 | 47825 | 13293 | 63427846 |
No adverse event | 52.41 | 12.38 | 104 | 47779 | 41301 | 63399838 |
Myasthenia gravis crisis | 51.54 | 12.38 | 18 | 47865 | 494 | 63440645 |
Weight decreased | 51.25 | 12.38 | 81 | 47802 | 276717 | 63164422 |
Platelet count increased | 51.24 | 12.38 | 65 | 47818 | 17646 | 63423493 |
Infusion related reaction | 51.23 | 12.38 | 66 | 47817 | 245455 | 63195684 |
Muscle spasms | 51.09 | 12.38 | 27 | 47856 | 156123 | 63285016 |
Gait disturbance | 49.93 | 12.38 | 39 | 47844 | 183139 | 63258000 |
Vasculitis | 49.81 | 12.38 | 65 | 47818 | 18144 | 63422995 |
Influenza B virus test positive | 49.54 | 12.38 | 15 | 47868 | 258 | 63440881 |
Pathogen resistance | 49.44 | 12.38 | 40 | 47843 | 6358 | 63434781 |
Encephalitis | 49.35 | 12.38 | 46 | 47837 | 8834 | 63432305 |
Mobility decreased | 49.33 | 12.38 | 15 | 47868 | 121144 | 63319995 |
Dermatitis bullous | 49.08 | 12.38 | 45 | 47838 | 8463 | 63432676 |
Renal failure | 48.98 | 12.38 | 197 | 47686 | 117455 | 63323684 |
Sinusitis | 48.25 | 12.38 | 60 | 47823 | 226593 | 63214546 |
Breath sounds abnormal | 48.23 | 12.38 | 50 | 47833 | 10923 | 63430216 |
Symmetrical drug-related intertriginous and flexural exanthema | 47.99 | 12.38 | 17 | 47866 | 487 | 63440652 |
Psoriasis | 47.75 | 12.38 | 5 | 47878 | 86952 | 63354187 |
Hydronephrosis | 47.61 | 12.38 | 49 | 47834 | 10613 | 63430526 |
Product use issue | 47.34 | 12.38 | 58 | 47825 | 220462 | 63220677 |
Rash morbilliform | 46.97 | 12.38 | 30 | 47853 | 3295 | 63437844 |
Shock | 46.77 | 12.38 | 72 | 47811 | 23391 | 63417748 |
Acute respiratory failure | 46.54 | 12.38 | 89 | 47794 | 34396 | 63406743 |
Nausea | 46.03 | 12.38 | 418 | 47465 | 854053 | 62587086 |
Cholangitis | 45.60 | 12.38 | 36 | 47847 | 5525 | 63435614 |
Gastrointestinal disorder | 45.49 | 12.38 | 21 | 47862 | 131218 | 63309921 |
Rhinitis allergic | 45.47 | 12.38 | 50 | 47833 | 11677 | 63429462 |
Depression | 45.07 | 12.38 | 49 | 47834 | 196443 | 63244696 |
Premature baby | 44.70 | 12.38 | 66 | 47817 | 20669 | 63420470 |
Lower respiratory tract infection | 44.59 | 12.38 | 22 | 47861 | 132285 | 63308854 |
SJS-TEN overlap | 44.16 | 12.38 | 15 | 47868 | 378 | 63440761 |
CSF oligoclonal band present | 43.90 | 12.38 | 15 | 47868 | 385 | 63440754 |
Stenotrophomonas infection | 43.62 | 12.38 | 24 | 47859 | 2003 | 63439136 |
Malaise | 43.57 | 12.38 | 164 | 47719 | 415790 | 63025349 |
Pancytopenia | 43.33 | 12.38 | 166 | 47717 | 96767 | 63344372 |
Cross sensitivity reaction | 42.18 | 12.38 | 24 | 47859 | 2138 | 63439001 |
Ill-defined disorder | 41.71 | 12.38 | 6 | 47877 | 81749 | 63359390 |
Migraine | 41.70 | 12.38 | 13 | 47870 | 103333 | 63337806 |
Neutrophilia | 41.56 | 12.38 | 31 | 47852 | 4375 | 63436764 |
Folliculitis | 41.44 | 12.38 | 3 | 47880 | 70314 | 63370825 |
Stress cardiomyopathy | 41.42 | 12.38 | 43 | 47840 | 9407 | 63431732 |
Stomatitis | 41.12 | 12.38 | 27 | 47856 | 138698 | 63302441 |
Leukopenia | 41.03 | 12.38 | 140 | 47743 | 77150 | 63363989 |
Hepatic cytolysis | 40.60 | 12.38 | 54 | 47829 | 15353 | 63425786 |
Osteoarthritis | 40.29 | 12.38 | 11 | 47872 | 95332 | 63345807 |
Treatment failure | 39.99 | 12.38 | 55 | 47828 | 198988 | 63242151 |
Pyuria | 39.38 | 12.38 | 22 | 47861 | 1892 | 63439247 |
Pyelonephritis | 38.92 | 12.38 | 57 | 47826 | 17721 | 63423418 |
Nosocomial infection | 38.76 | 12.38 | 21 | 47862 | 1700 | 63439439 |
Drug resistance | 38.37 | 12.38 | 65 | 47818 | 22868 | 63418271 |
Injection site erythema | 38.29 | 12.38 | 8 | 47875 | 83166 | 63357973 |
Rash erythematous | 38.14 | 12.38 | 93 | 47790 | 42417 | 63398722 |
Guillain-Barre syndrome | 38.09 | 12.38 | 28 | 47855 | 3865 | 63437274 |
Arthritis | 37.97 | 12.38 | 20 | 47863 | 115901 | 63325238 |
Maternal exposure during pregnancy | 37.97 | 12.38 | 290 | 47593 | 219772 | 63221367 |
Hypokalaemia | 37.89 | 12.38 | 167 | 47716 | 103637 | 63337502 |
Abdominal pain upper | 37.63 | 12.38 | 61 | 47822 | 206383 | 63234756 |
Haemolysis | 37.50 | 12.38 | 35 | 47848 | 6733 | 63434406 |
Haemodynamic instability | 37.06 | 12.38 | 40 | 47843 | 9150 | 63431989 |
Propofol infusion syndrome | 37.00 | 12.38 | 17 | 47866 | 966 | 63440173 |
International normalised ratio increased | 36.90 | 12.38 | 97 | 47786 | 46328 | 63394811 |
Fibromyalgia | 36.48 | 12.38 | 8 | 47875 | 80412 | 63360727 |
Upper-airway cough syndrome | 36.39 | 12.38 | 44 | 47839 | 11374 | 63429765 |
Myopathy toxic | 36.19 | 12.38 | 14 | 47869 | 516 | 63440623 |
Hypertension | 35.53 | 12.38 | 101 | 47782 | 279202 | 63161937 |
Hepatic enzyme increased | 34.84 | 12.38 | 62 | 47821 | 202266 | 63238873 |
Immune reconstitution inflammatory syndrome | 34.75 | 12.38 | 32 | 47851 | 6052 | 63435087 |
Impaired healing | 34.62 | 12.38 | 17 | 47866 | 102525 | 63338614 |
Respiratory distress | 34.52 | 12.38 | 78 | 47805 | 33873 | 63407266 |
Klebsiella infection | 34.04 | 12.38 | 37 | 47846 | 8529 | 63432610 |
Angioedema | 33.91 | 12.38 | 96 | 47787 | 47869 | 63393270 |
Partial seizures | 33.90 | 12.38 | 31 | 47852 | 5811 | 63435328 |
Blood creatinine increased | 33.34 | 12.38 | 143 | 47740 | 87701 | 63353438 |
Normal newborn | 33.10 | 12.38 | 36 | 47847 | 8305 | 63432834 |
Leukaemoid reaction | 32.97 | 12.38 | 10 | 47873 | 173 | 63440966 |
CSF measles antibody positive | 32.81 | 12.38 | 8 | 47875 | 57 | 63441082 |
Hepatitis infectious mononucleosis | 32.71 | 12.38 | 9 | 47874 | 108 | 63441031 |
Weber tuning fork test abnormal | 32.56 | 12.38 | 9 | 47874 | 110 | 63441029 |
Hypertransaminasaemia | 32.49 | 12.38 | 32 | 47851 | 6577 | 63434562 |
Cyanosis | 32.40 | 12.38 | 51 | 47832 | 16884 | 63424255 |
Hypoaesthesia | 32.36 | 12.38 | 48 | 47835 | 168345 | 63272794 |
Oliguria | 32.21 | 12.38 | 37 | 47846 | 9064 | 63432075 |
Rubella antibody positive | 32.00 | 12.38 | 8 | 47875 | 64 | 63441075 |
Mitochondrial DNA mutation | 31.88 | 12.38 | 12 | 47871 | 410 | 63440729 |
Unresponsive to stimuli | 31.43 | 12.38 | 75 | 47808 | 33741 | 63407398 |
Lip oedema | 31.31 | 12.38 | 25 | 47858 | 3899 | 63437240 |
Enterobacter infection | 31.23 | 12.38 | 20 | 47863 | 2207 | 63438932 |
Aspartate aminotransferase increased | 30.52 | 12.38 | 142 | 47741 | 90135 | 63351004 |
Intentional overdose | 30.51 | 12.38 | 9 | 47874 | 74143 | 63366996 |
Death | 30.51 | 12.38 | 162 | 47721 | 374219 | 63066920 |
Hepatic function abnormal | 29.92 | 12.38 | 78 | 47805 | 37064 | 63404075 |
Sneezing | 29.64 | 12.38 | 51 | 47832 | 18167 | 63422972 |
Neurotoxicity | 29.55 | 12.38 | 49 | 47834 | 16941 | 63424198 |
Blood brain barrier defect | 29.47 | 12.38 | 8 | 47875 | 91 | 63441048 |
Systemic inflammatory response syndrome | 29.10 | 12.38 | 28 | 47855 | 5593 | 63435546 |
Back pain | 29.04 | 12.38 | 102 | 47781 | 264043 | 63177096 |
Agitation | 28.91 | 12.38 | 105 | 47778 | 59652 | 63381487 |
Dyspepsia | 28.80 | 12.38 | 21 | 47862 | 102175 | 63338964 |
Hypotension | 28.65 | 12.38 | 323 | 47560 | 272281 | 63168858 |
Sleep disorder | 28.34 | 12.38 | 13 | 47870 | 81553 | 63359586 |
Adverse event | 28.16 | 12.38 | 8 | 47875 | 67551 | 63373588 |
Gastroenteritis clostridial | 27.94 | 12.38 | 12 | 47871 | 580 | 63440559 |
Fibrin D dimer increased | 27.83 | 12.38 | 26 | 47857 | 5008 | 63436131 |
Dermatitis exfoliative generalised | 27.73 | 12.38 | 23 | 47860 | 3784 | 63437355 |
Blood gases abnormal | 27.56 | 12.38 | 13 | 47870 | 784 | 63440355 |
Haemoperitoneum | 27.46 | 12.38 | 20 | 47863 | 2721 | 63438418 |
Memory impairment | 27.39 | 12.38 | 23 | 47860 | 104235 | 63336904 |
Multiple-drug resistance | 27.24 | 12.38 | 26 | 47857 | 5144 | 63435995 |
Alanine aminotransferase increased | 27.22 | 12.38 | 152 | 47731 | 103618 | 63337521 |
Feeling abnormal | 26.89 | 12.38 | 44 | 47839 | 148348 | 63292791 |
Laryngeal stenosis | 26.66 | 12.38 | 14 | 47869 | 1064 | 63440075 |
Bile duct stone | 26.45 | 12.38 | 22 | 47861 | 3634 | 63437505 |
Factor V deficiency | 26.17 | 12.38 | 7 | 47876 | 75 | 63441064 |
Dry mouth | 26.14 | 12.38 | 13 | 47870 | 77850 | 63363289 |
COVID-19 pneumonia | 26.09 | 12.38 | 42 | 47841 | 14167 | 63426972 |
Electrolyte imbalance | 26.09 | 12.38 | 51 | 47832 | 20025 | 63421114 |
Drug abuse | 26.07 | 12.38 | 11 | 47872 | 72507 | 63368632 |
Cholestatic liver injury | 26.05 | 12.38 | 19 | 47864 | 2591 | 63438548 |
CSF protein increased | 26.05 | 12.38 | 11 | 47872 | 510 | 63440629 |
Pelvic inflammatory disease | 26.00 | 12.38 | 16 | 47867 | 1646 | 63439493 |
Gene mutation | 25.98 | 12.38 | 16 | 47867 | 1649 | 63439490 |
Autoimmune haemolytic anaemia | 25.89 | 12.38 | 24 | 47859 | 4577 | 63436562 |
Face oedema | 25.85 | 12.38 | 51 | 47832 | 20161 | 63420978 |
Erythema multiforme | 25.81 | 12.38 | 35 | 47848 | 10134 | 63431005 |
Hepatitis acute | 25.63 | 12.38 | 33 | 47850 | 9087 | 63432052 |
Balance disorder | 25.60 | 12.38 | 16 | 47867 | 84406 | 63356733 |
Escherichia infection | 25.22 | 12.38 | 39 | 47844 | 12715 | 63428424 |
Cardiogenic shock | 25.08 | 12.38 | 47 | 47836 | 17885 | 63423254 |
Toxic skin eruption | 24.92 | 12.38 | 39 | 47844 | 12846 | 63428293 |
Bronchial obstruction | 24.84 | 12.38 | 15 | 47868 | 1492 | 63439647 |
Nephropathy toxic | 24.63 | 12.38 | 33 | 47850 | 9446 | 63431693 |
Intervertebral discitis | 24.56 | 12.38 | 20 | 47863 | 3208 | 63437931 |
Anuria | 24.29 | 12.38 | 38 | 47845 | 12513 | 63428626 |
Disseminated intravascular coagulation | 24.28 | 12.38 | 48 | 47835 | 19003 | 63422136 |
Blood pressure increased | 24.16 | 12.38 | 54 | 47829 | 162008 | 63279131 |
Eosinophilic pneumonia | 24.14 | 12.38 | 17 | 47866 | 2194 | 63438945 |
Clostridium colitis | 23.93 | 12.38 | 16 | 47867 | 1898 | 63439241 |
Palpitations | 23.82 | 12.38 | 30 | 47853 | 112740 | 63328399 |
Therapeutic product effect incomplete | 23.68 | 12.38 | 36 | 47847 | 125020 | 63316119 |
Hyporesponsive to stimuli | 23.56 | 12.38 | 13 | 47870 | 1091 | 63440048 |
Organic brain syndrome | 23.50 | 12.38 | 8 | 47875 | 203 | 63440936 |
Musculoskeletal pain | 23.46 | 12.38 | 21 | 47862 | 92256 | 63348883 |
Abdominal wall haematoma | 23.39 | 12.38 | 19 | 47864 | 3036 | 63438103 |
Muscle tension dysphonia | 23.39 | 12.38 | 8 | 47875 | 206 | 63440933 |
Coombs negative haemolytic anaemia | 23.32 | 12.38 | 8 | 47875 | 208 | 63440931 |
Suicidal ideation | 23.20 | 12.38 | 9 | 47874 | 62412 | 63378727 |
Renal tubular necrosis | 23.04 | 12.38 | 36 | 47847 | 11842 | 63429297 |
Vascular device infection | 23.01 | 12.38 | 28 | 47855 | 7284 | 63433855 |
Full blood count abnormal | 22.92 | 12.38 | 64 | 47819 | 31653 | 63409486 |
Thunderclap headache | 22.79 | 12.38 | 8 | 47875 | 223 | 63440916 |
Lacrimation increased | 22.78 | 12.38 | 49 | 47834 | 20582 | 63420557 |
Cholangitis acute | 22.63 | 12.38 | 10 | 47873 | 518 | 63440621 |
Anxiety | 22.58 | 12.38 | 86 | 47797 | 217455 | 63223684 |
Eye pruritus | 22.55 | 12.38 | 46 | 47837 | 18625 | 63422514 |
Encephalitis brain stem | 22.47 | 12.38 | 7 | 47876 | 133 | 63441006 |
Blood pressure fluctuation | 22.27 | 12.38 | 4 | 47879 | 46313 | 63394826 |
Haemostasis | 22.17 | 12.38 | 8 | 47875 | 242 | 63440897 |
Type IV hypersensitivity reaction | 22.14 | 12.38 | 18 | 47865 | 2880 | 63438259 |
Jaundice | 22.11 | 12.38 | 60 | 47823 | 29191 | 63411948 |
Product use in unapproved indication | 21.99 | 12.38 | 219 | 47664 | 178861 | 63262278 |
Pyelonephritis acute | 21.95 | 12.38 | 22 | 47861 | 4619 | 63436520 |
Otitis media acute | 21.85 | 12.38 | 12 | 47871 | 998 | 63440141 |
Myocardial infarction | 21.70 | 12.38 | 26 | 47857 | 99867 | 63341272 |
Multiple sclerosis relapse | 21.62 | 12.38 | 5 | 47878 | 48473 | 63392666 |
Hyperbilirubinaemia | 21.54 | 12.38 | 34 | 47849 | 11280 | 63429859 |
Haemodialysis | 21.51 | 12.38 | 30 | 47853 | 8917 | 63432222 |
Endocarditis | 21.40 | 12.38 | 24 | 47859 | 5726 | 63435413 |
Renal papillary necrosis | 21.40 | 12.38 | 8 | 47875 | 268 | 63440871 |
Bacteriuria | 21.38 | 12.38 | 12 | 47871 | 1041 | 63440098 |
Paraesthesia | 21.26 | 12.38 | 55 | 47828 | 156911 | 63284228 |
Hospitalisation | 20.87 | 12.38 | 20 | 47863 | 85061 | 63356078 |
Veillonella infection | 20.84 | 12.38 | 5 | 47878 | 33 | 63441106 |
Drug eruption | 20.84 | 12.38 | 58 | 47825 | 28636 | 63412503 |
Coagulation factor deficiency | 20.72 | 12.38 | 4 | 47879 | 7 | 63441132 |
Pneumonia necrotising | 20.71 | 12.38 | 9 | 47874 | 448 | 63440691 |
Pancreatitis necrotising | 20.66 | 12.38 | 14 | 47869 | 1698 | 63439441 |
Hyperglycaemia | 20.62 | 12.38 | 74 | 47809 | 41793 | 63399346 |
Laryngeal mass | 20.58 | 12.38 | 5 | 47878 | 35 | 63441104 |
Rhinocerebral mucormycosis | 20.56 | 12.38 | 9 | 47874 | 456 | 63440683 |
Morganella infection | 20.34 | 12.38 | 10 | 47873 | 661 | 63440478 |
Confabulation | 20.25 | 12.38 | 8 | 47875 | 312 | 63440827 |
Meningitis | 20.22 | 12.38 | 26 | 47857 | 7151 | 63433988 |
Iris transillumination defect | 20.10 | 12.38 | 6 | 47877 | 98 | 63441041 |
Meningism | 20.02 | 12.38 | 9 | 47874 | 486 | 63440653 |
Encephalitis autoimmune | 19.99 | 12.38 | 13 | 47870 | 1473 | 63439666 |
Cataract | 19.96 | 12.38 | 9 | 47874 | 57044 | 63384095 |
Infection | 19.87 | 12.38 | 97 | 47786 | 229076 | 63212063 |
Type I hypersensitivity | 19.84 | 12.38 | 17 | 47866 | 2925 | 63438214 |
Influenza like illness | 19.80 | 12.38 | 13 | 47870 | 66811 | 63374328 |
Myocarditis | 19.62 | 12.38 | 31 | 47852 | 10294 | 63430845 |
Foetal death | 19.54 | 12.38 | 32 | 47851 | 10948 | 63430191 |
Intravascular haemolysis | 19.53 | 12.38 | 8 | 47875 | 343 | 63440796 |
Postpartum sepsis | 19.48 | 12.38 | 4 | 47879 | 11 | 63441128 |
Hepatosplenomegaly | 19.48 | 12.38 | 16 | 47867 | 2598 | 63438541 |
Eyelid oedema | 19.28 | 12.38 | 31 | 47852 | 10448 | 63430691 |
Erythema nodosum | 19.27 | 12.38 | 21 | 47862 | 4854 | 63436285 |
Aspergillus infection | 19.26 | 12.38 | 27 | 47856 | 8066 | 63433073 |
Bronchopleural fistula | 19.21 | 12.38 | 7 | 47876 | 218 | 63440921 |
Transverse sinus thrombosis | 18.99 | 12.38 | 9 | 47874 | 549 | 63440590 |
Acquired haemophilia | 18.92 | 12.38 | 11 | 47872 | 1020 | 63440119 |
Blood potassium decreased | 18.79 | 12.38 | 72 | 47811 | 41954 | 63399185 |
Stress | 18.67 | 12.38 | 14 | 47869 | 67153 | 63373986 |
Conjunctival hyperaemia | 18.65 | 12.38 | 15 | 47868 | 2364 | 63438775 |
Red blood cell agglutination | 18.57 | 12.38 | 3 | 47880 | 0 | 63441139 |
Anti factor V antibody | 18.57 | 12.38 | 3 | 47880 | 0 | 63441139 |
Acute hepatic failure | 18.51 | 12.38 | 42 | 47841 | 18285 | 63422854 |
Meningitis bacterial | 18.49 | 12.38 | 12 | 47871 | 1355 | 63439784 |
Gastric disorder | 18.47 | 12.38 | 3 | 47880 | 37366 | 63403773 |
Respiratory acidosis | 18.41 | 12.38 | 24 | 47859 | 6691 | 63434448 |
Dry skin | 18.35 | 12.38 | 10 | 47873 | 56877 | 63384262 |
Visual impairment | 18.32 | 12.38 | 22 | 47861 | 84424 | 63356715 |
Inflammatory marker increased | 18.06 | 12.38 | 24 | 47859 | 6815 | 63434324 |
Eosinophilic pneumonia acute | 18.04 | 12.38 | 8 | 47875 | 418 | 63440721 |
Mixed liver injury | 18.03 | 12.38 | 20 | 47863 | 4715 | 63436424 |
Bronchospasm | 17.90 | 12.38 | 40 | 47843 | 17240 | 63423899 |
Bacteraemia | 17.79 | 12.38 | 40 | 47843 | 17308 | 63423831 |
Gastrooesophageal reflux disease | 17.66 | 12.38 | 28 | 47855 | 95611 | 63345528 |
Hypofibrinogenaemia | 17.64 | 12.38 | 11 | 47872 | 1159 | 63439980 |
Injection site pruritus | 17.62 | 12.38 | 6 | 47877 | 45110 | 63396029 |
Hyperthyroidism | 17.54 | 12.38 | 36 | 47847 | 14637 | 63426502 |
Clostridial infection | 17.50 | 12.38 | 19 | 47864 | 4373 | 63436766 |
Lactic acidosis | 17.45 | 12.38 | 66 | 47817 | 38221 | 63402918 |
Purpura | 17.39 | 12.38 | 31 | 47852 | 11354 | 63429785 |
Cholecystitis acute | 17.38 | 12.38 | 26 | 47857 | 8234 | 63432905 |
Herpes zoster | 17.35 | 12.38 | 22 | 47861 | 82440 | 63358699 |
Asymptomatic bacteriuria | 17.34 | 12.38 | 7 | 47876 | 289 | 63440850 |
Normochromic anaemia | 17.30 | 12.38 | 7 | 47876 | 291 | 63440848 |
Cerebral artery stenosis | 17.13 | 12.38 | 8 | 47875 | 472 | 63440667 |
Foetal exposure during pregnancy | 17.04 | 12.38 | 58 | 47825 | 31904 | 63409235 |
Pseudophaeochromocytoma | 17.03 | 12.38 | 5 | 47878 | 77 | 63441062 |
Vision blurred | 16.89 | 12.38 | 27 | 47856 | 91897 | 63349242 |
Therapeutic response decreased | 16.87 | 12.38 | 13 | 47870 | 61512 | 63379627 |
Unmasking of previously unidentified disease | 16.83 | 12.38 | 10 | 47873 | 966 | 63440173 |
Hyperpyrexia | 16.78 | 12.38 | 17 | 47866 | 3615 | 63437524 |
Haematoma | 16.68 | 12.38 | 61 | 47822 | 34759 | 63406380 |
Septic pulmonary embolism | 16.68 | 12.38 | 5 | 47878 | 83 | 63441056 |
Skin test positive | 16.68 | 12.38 | 9 | 47874 | 723 | 63440416 |
Nocardiosis | 16.65 | 12.38 | 13 | 47870 | 1963 | 63439176 |
Hypoalbuminaemia | 16.58 | 12.38 | 31 | 47852 | 11774 | 63429365 |
Antibiotic associated colitis | 16.50 | 12.38 | 3 | 47880 | 3 | 63441136 |
Ventricular fibrillation | 16.47 | 12.38 | 31 | 47852 | 11836 | 63429303 |
Sciatica | 16.43 | 12.38 | 3 | 47880 | 34321 | 63406818 |
Infantile apnoea | 16.30 | 12.38 | 10 | 47873 | 1023 | 63440116 |
Hyperlactacidaemia | 16.30 | 12.38 | 15 | 47868 | 2834 | 63438305 |
Foetal growth restriction | 16.22 | 12.38 | 24 | 47859 | 7529 | 63433610 |
Anaemia | 16.21 | 12.38 | 311 | 47572 | 293119 | 63148020 |
Bursitis | 16.17 | 12.38 | 4 | 47879 | 37037 | 63404102 |
Relapsing fever | 16.11 | 12.38 | 6 | 47877 | 199 | 63440940 |
Device related bacteraemia | 16.05 | 12.38 | 6 | 47877 | 201 | 63440938 |
Coagulation factor decreased | 16.05 | 12.38 | 5 | 47878 | 95 | 63441044 |
Blood creatine phosphokinase increased | 16.03 | 12.38 | 55 | 47828 | 30375 | 63410764 |
Inappropriate schedule of product administration | 16.02 | 12.38 | 34 | 47849 | 103931 | 63337208 |
Hyperkalaemia | 15.98 | 12.38 | 82 | 47801 | 54121 | 63387018 |
Wound haemorrhage | 15.88 | 12.38 | 14 | 47869 | 2502 | 63438637 |
Hypercreatininaemia | 15.81 | 12.38 | 8 | 47875 | 563 | 63440576 |
Idiosyncratic drug reaction | 15.64 | 12.38 | 9 | 47874 | 819 | 63440320 |
Hyperthermia malignant | 15.58 | 12.38 | 9 | 47874 | 825 | 63440314 |
Ear pain | 15.57 | 12.38 | 4 | 47879 | 36114 | 63405025 |
Generalised bullous fixed drug eruption | 15.53 | 12.38 | 5 | 47878 | 106 | 63441033 |
Toxicity to various agents | 15.46 | 12.38 | 116 | 47767 | 247134 | 63194005 |
Anoxia | 15.29 | 12.38 | 6 | 47877 | 230 | 63440909 |
Post treatment Lyme disease syndrome | 15.28 | 12.38 | 3 | 47880 | 6 | 63441133 |
Fixed eruption | 15.21 | 12.38 | 10 | 47873 | 1154 | 63439985 |
Night sweats | 15.15 | 12.38 | 9 | 47874 | 48805 | 63392334 |
Pancreatitis acute | 15.11 | 12.38 | 50 | 47833 | 27116 | 63414023 |
Adverse drug reaction | 15.04 | 12.38 | 23 | 47860 | 79691 | 63361448 |
Arthritis reactive | 15.02 | 12.38 | 7 | 47876 | 411 | 63440728 |
Thrombosis | 14.99 | 12.38 | 16 | 47867 | 64739 | 63376400 |
Candida test positive | 14.98 | 12.38 | 9 | 47874 | 887 | 63440252 |
Septic embolus | 14.97 | 12.38 | 9 | 47874 | 888 | 63440251 |
Gamma-glutamyltransferase increased | 14.96 | 12.38 | 58 | 47825 | 33973 | 63407166 |
Anticonvulsant drug level below therapeutic | 14.96 | 12.38 | 8 | 47875 | 631 | 63440508 |
Cerebral aspergillosis | 14.95 | 12.38 | 7 | 47876 | 415 | 63440724 |
Stomatococcal infection | 14.95 | 12.38 | 5 | 47878 | 120 | 63441019 |
Brain herniation | 14.82 | 12.38 | 16 | 47867 | 3661 | 63437478 |
Pneumonia mycoplasmal | 14.71 | 12.38 | 9 | 47874 | 916 | 63440223 |
Vitamin K deficiency | 14.68 | 12.38 | 7 | 47876 | 433 | 63440706 |
Ureterolithiasis | 14.65 | 12.38 | 12 | 47871 | 1940 | 63439199 |
Generalised oedema | 14.61 | 12.38 | 35 | 47848 | 15783 | 63425356 |
Ventricular dysfunction | 14.48 | 12.38 | 14 | 47869 | 2814 | 63438325 |
Amniotic cavity infection | 14.47 | 12.38 | 10 | 47873 | 1253 | 63439886 |
Central nervous system vasculitis | 14.46 | 12.38 | 9 | 47874 | 945 | 63440194 |
Chemotherapeutic drug level increased | 14.36 | 12.38 | 5 | 47878 | 136 | 63441003 |
Constipation | 14.32 | 12.38 | 105 | 47778 | 224838 | 63216301 |
Petechiae | 14.20 | 12.38 | 32 | 47851 | 13865 | 63427274 |
Hypertensive heart disease | 14.20 | 12.38 | 13 | 47870 | 2439 | 63438700 |
Anti-platelet antibody positive | 14.18 | 12.38 | 4 | 47879 | 53 | 63441086 |
Hyperthermia | 14.07 | 12.38 | 25 | 47858 | 9131 | 63432008 |
Nephritis | 13.92 | 12.38 | 13 | 47870 | 2503 | 63438636 |
Drug hypersensitivity | 13.81 | 12.38 | 319 | 47564 | 310368 | 63130771 |
Condition aggravated | 13.80 | 12.38 | 399 | 47484 | 401818 | 63039321 |
Eye inflammation | 13.80 | 12.38 | 19 | 47864 | 5580 | 63435559 |
Orthostatic hypotension | 13.80 | 12.38 | 5 | 47878 | 36155 | 63404984 |
Granulomatous dermatitis | 13.71 | 12.38 | 5 | 47878 | 156 | 63440983 |
Localised infection | 13.71 | 12.38 | 3 | 47880 | 30207 | 63410932 |
Stridor | 13.67 | 12.38 | 15 | 47868 | 3495 | 63437644 |
Fluid retention | 13.54 | 12.38 | 15 | 47868 | 59671 | 63381468 |
Alpha 1 microglobulin increased | 13.48 | 12.38 | 4 | 47879 | 64 | 63441075 |
Apgar score low | 13.43 | 12.38 | 8 | 47875 | 776 | 63440363 |
Prescribed underdose | 13.37 | 12.38 | 3 | 47880 | 29686 | 63411453 |
Superior sagittal sinus thrombosis | 13.37 | 12.38 | 8 | 47875 | 783 | 63440356 |
Dysmetria | 13.35 | 12.38 | 7 | 47876 | 530 | 63440609 |
Decreased appetite | 13.33 | 12.38 | 123 | 47760 | 250929 | 63190210 |
Joint injury | 13.29 | 12.38 | 3 | 47880 | 29569 | 63411570 |
Deafness bilateral | 13.28 | 12.38 | 10 | 47873 | 1432 | 63439707 |
Dysphemia | 13.24 | 12.38 | 13 | 47870 | 2662 | 63438477 |
Loss of personal independence in daily activities | 13.24 | 12.38 | 34 | 47849 | 97256 | 63343883 |
Hemianopia | 13.24 | 12.38 | 9 | 47874 | 1098 | 63440041 |
Oropharyngeal discomfort | 13.19 | 12.38 | 18 | 47865 | 5242 | 63435897 |
Muscle haemorrhage | 13.10 | 12.38 | 14 | 47869 | 3165 | 63437974 |
Sleep apnoea syndrome | 13.00 | 12.38 | 3 | 47880 | 29130 | 63412009 |
Cardiac tamponade | 12.99 | 12.38 | 17 | 47866 | 4758 | 63436381 |
Splenomegaly | 12.90 | 12.38 | 27 | 47856 | 11130 | 63430009 |
Systemic candida | 12.87 | 12.38 | 14 | 47869 | 3231 | 63437908 |
Procalcitonin increased | 12.86 | 12.38 | 9 | 47874 | 1150 | 63439989 |
Muscle strength abnormal | 12.84 | 12.38 | 4 | 47879 | 76 | 63441063 |
Hypoxic-ischaemic encephalopathy | 12.82 | 12.38 | 16 | 47867 | 4271 | 63436868 |
Foaming at mouth | 12.80 | 12.38 | 9 | 47874 | 1159 | 63439980 |
Peri-implantitis | 12.79 | 12.38 | 4 | 47879 | 77 | 63441062 |
Chest discomfort | 12.77 | 12.38 | 133 | 47750 | 109836 | 63331303 |
Base excess | 12.74 | 12.38 | 4 | 47879 | 78 | 63441061 |
Vaccination complication | 12.74 | 12.38 | 9 | 47874 | 1168 | 63439971 |
Normocytic anaemia | 12.66 | 12.38 | 11 | 47872 | 1929 | 63439210 |
Dysgeusia | 12.64 | 12.38 | 10 | 47873 | 46700 | 63394439 |
Febrile infection | 12.59 | 12.38 | 10 | 47873 | 1547 | 63439592 |
Chorioretinitis | 12.57 | 12.38 | 7 | 47876 | 598 | 63440541 |
Blood urea increased | 12.46 | 12.38 | 46 | 47837 | 26333 | 63414806 |
Leukoencephalopathy | 12.45 | 12.38 | 16 | 47867 | 4397 | 63436742 |
Overlap syndrome | 12.45 | 12.38 | 8 | 47875 | 888 | 63440251 |
Staphylococcus test positive | 12.39 | 12.38 | 15 | 47868 | 3881 | 63437258 |
Microangiopathic haemolytic anaemia | 12.38 | 12.38 | 7 | 47876 | 616 | 63440523 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Off label use | 512.53 | 12.17 | 1586 | 51158 | 417938 | 34486249 |
Drug reaction with eosinophilia and systemic symptoms | 445.03 | 12.17 | 381 | 52363 | 32631 | 34871556 |
Postrenal failure | 291.90 | 12.17 | 78 | 52666 | 377 | 34903810 |
Jarisch-Herxheimer reaction | 262.79 | 12.17 | 76 | 52668 | 515 | 34903672 |
Appendicolith | 235.18 | 12.17 | 152 | 52592 | 8449 | 34895738 |
Pseudocholelithiasis | 225.43 | 12.17 | 41 | 52703 | 0 | 34904187 |
Rash maculo-papular | 197.65 | 12.17 | 229 | 52515 | 28222 | 34875965 |
Appendicitis | 197.54 | 12.17 | 170 | 52574 | 14637 | 34889550 |
Multiple organ dysfunction syndrome | 185.08 | 12.17 | 377 | 52367 | 76189 | 34827998 |
Fatigue | 173.17 | 12.17 | 183 | 52561 | 370470 | 34533717 |
Acute generalised exanthematous pustulosis | 171.24 | 12.17 | 114 | 52630 | 6662 | 34897525 |
Cardiogenic shock | 169.59 | 12.17 | 205 | 52539 | 26413 | 34877774 |
Acute kidney injury | 163.03 | 12.17 | 896 | 51848 | 304092 | 34600095 |
Hepatocellular injury | 159.68 | 12.17 | 182 | 52562 | 22029 | 34882158 |
Toxic epidermal necrolysis | 135.09 | 12.17 | 165 | 52579 | 21481 | 34882706 |
Cholelithiasis | 133.27 | 12.17 | 162 | 52582 | 20986 | 34883201 |
Cholestasis | 133.13 | 12.17 | 183 | 52561 | 26765 | 34877422 |
Eosinophilia | 132.46 | 12.17 | 180 | 52564 | 26042 | 34878145 |
Agranulocytosis | 131.83 | 12.17 | 171 | 52573 | 23650 | 34880537 |
Death | 129.15 | 12.17 | 254 | 52490 | 397795 | 34506392 |
Hypertransaminasaemia | 119.65 | 12.17 | 85 | 52659 | 5521 | 34898666 |
Toxic encephalopathy | 117.63 | 12.17 | 82 | 52662 | 5167 | 34899020 |
Drug ineffective for unapproved indication | 115.57 | 12.17 | 160 | 52584 | 23555 | 34880632 |
Drug abuse | 115.42 | 12.17 | 9 | 52735 | 99087 | 34805100 |
Product dose omission issue | 112.54 | 12.17 | 22 | 52722 | 119689 | 34784498 |
Ventricular fibrillation | 110.56 | 12.17 | 154 | 52590 | 22800 | 34881387 |
Kounis syndrome | 103.91 | 12.17 | 58 | 52686 | 2460 | 34901727 |
Anaphylactic shock | 103.51 | 12.17 | 124 | 52620 | 15817 | 34888370 |
Pathogen resistance | 101.12 | 12.17 | 96 | 52648 | 9386 | 34894801 |
Pyrexia | 100.48 | 12.17 | 850 | 51894 | 332163 | 34572024 |
Dizziness | 99.42 | 12.17 | 110 | 52634 | 218411 | 34685776 |
Anaphylactic reaction | 93.78 | 12.17 | 172 | 52572 | 32129 | 34872058 |
Hepatitis | 92.93 | 12.17 | 145 | 52599 | 23759 | 34880428 |
Clostridium test positive | 91.19 | 12.17 | 59 | 52685 | 3283 | 34900904 |
Fall | 90.23 | 12.17 | 104 | 52640 | 202781 | 34701406 |
Ascites | 89.27 | 12.17 | 209 | 52535 | 46362 | 34857825 |
Blood phosphorus increased | 87.77 | 12.17 | 81 | 52663 | 7640 | 34896547 |
Stress | 87.35 | 12.17 | 161 | 52583 | 30186 | 34874001 |
Clostridium difficile colitis | 87.14 | 12.17 | 113 | 52631 | 15617 | 34888570 |
Drug-induced liver injury | 86.84 | 12.17 | 156 | 52588 | 28676 | 34875511 |
Depression | 86.83 | 12.17 | 20 | 52724 | 97078 | 34807109 |
Ureterolithiasis | 85.45 | 12.17 | 49 | 52695 | 2190 | 34901997 |
Bronchopulmonary aspergillosis | 83.87 | 12.17 | 107 | 52637 | 14552 | 34889635 |
Factor V inhibition | 81.69 | 12.17 | 24 | 52720 | 173 | 34904014 |
Haemolytic anaemia | 80.65 | 12.17 | 89 | 52655 | 10390 | 34893797 |
Recalled product administered | 78.95 | 12.17 | 30 | 52714 | 511 | 34903676 |
Long QT syndrome | 77.75 | 12.17 | 50 | 52694 | 2753 | 34901434 |
Respiratory failure | 76.83 | 12.17 | 346 | 52398 | 108226 | 34795961 |
Weight increased | 75.90 | 12.17 | 23 | 52721 | 93010 | 34811177 |
Immune reconstitution inflammatory syndrome | 73.73 | 12.17 | 78 | 52666 | 8681 | 34895506 |
Hyponatraemia | 71.33 | 12.17 | 280 | 52464 | 82411 | 34821776 |
Condition aggravated | 68.95 | 12.17 | 511 | 52233 | 191685 | 34712502 |
Pain | 68.40 | 12.17 | 128 | 52616 | 204547 | 34699640 |
Septic shock | 67.52 | 12.17 | 250 | 52494 | 71584 | 34832603 |
Haemolysis | 62.73 | 12.17 | 69 | 52675 | 8025 | 34896162 |
Alanine aminotransferase increased | 58.99 | 12.17 | 260 | 52484 | 80555 | 34823632 |
Tubulointerstitial nephritis | 58.56 | 12.17 | 110 | 52634 | 20914 | 34883273 |
Myocardial infarction | 58.30 | 12.17 | 58 | 52686 | 121027 | 34783160 |
Insomnia | 55.73 | 12.17 | 45 | 52699 | 103862 | 34800325 |
Hydronephrosis | 55.25 | 12.17 | 73 | 52671 | 10273 | 34893914 |
Joint swelling | 54.20 | 12.17 | 12 | 52732 | 59878 | 34844309 |
Electrocardiogram QT prolonged | 53.16 | 12.17 | 159 | 52585 | 40793 | 34863394 |
Stevens-Johnson syndrome | 52.51 | 12.17 | 98 | 52646 | 18541 | 34885646 |
Acute respiratory distress syndrome | 52.44 | 12.17 | 119 | 52625 | 25850 | 34878337 |
Abdominal discomfort | 52.14 | 12.17 | 13 | 52731 | 59822 | 34844365 |
Liver injury | 52.00 | 12.17 | 86 | 52658 | 14792 | 34889395 |
Nocardiosis | 51.94 | 12.17 | 45 | 52699 | 3906 | 34900281 |
Toxicity to various agents | 51.75 | 12.17 | 144 | 52600 | 200218 | 34703969 |
Cerebrovascular accident | 51.70 | 12.17 | 32 | 52712 | 84779 | 34819408 |
Arthralgia | 50.28 | 12.17 | 114 | 52630 | 169927 | 34734260 |
Blood glucose increased | 50.05 | 12.17 | 19 | 52725 | 66699 | 34837488 |
Sepsis | 49.37 | 12.17 | 424 | 52320 | 166137 | 34738050 |
Klebsiella infection | 48.37 | 12.17 | 62 | 52682 | 8469 | 34895718 |
Hospitalisation | 48.37 | 12.17 | 13 | 52731 | 56889 | 34847298 |
Brain abscess | 48.13 | 12.17 | 39 | 52705 | 3086 | 34901101 |
Trichosporon infection | 47.88 | 12.17 | 23 | 52721 | 711 | 34903476 |
Drug ineffective | 47.73 | 12.17 | 959 | 51785 | 455792 | 34448395 |
Anuria | 47.51 | 12.17 | 68 | 52676 | 10317 | 34893870 |
Rash morbilliform | 46.43 | 12.17 | 38 | 52706 | 3049 | 34901138 |
Inappropriate schedule of product administration | 46.30 | 12.17 | 18 | 52726 | 62278 | 34841909 |
Anxiety | 46.29 | 12.17 | 49 | 52695 | 99379 | 34804808 |
Mucormycosis | 44.91 | 12.17 | 50 | 52694 | 5892 | 34898295 |
Abdominal distension | 44.82 | 12.17 | 191 | 52553 | 58301 | 34845886 |
Pain in extremity | 44.10 | 12.17 | 77 | 52667 | 126436 | 34777751 |
Disseminated intravascular coagulation | 44.08 | 12.17 | 100 | 52644 | 21716 | 34882471 |
Cross sensitivity reaction | 43.97 | 12.17 | 27 | 52717 | 1370 | 34902817 |
Asthenia | 43.05 | 12.17 | 207 | 52537 | 245044 | 34659143 |
Candida infection | 42.44 | 12.17 | 87 | 52657 | 17628 | 34886559 |
Nasopharyngitis | 41.81 | 12.17 | 27 | 52717 | 69941 | 34834246 |
Disseminated cryptococcosis | 41.63 | 12.17 | 26 | 52718 | 1360 | 34902827 |
Transaminases increased | 41.51 | 12.17 | 111 | 52633 | 26712 | 34877475 |
Product use in unapproved indication | 41.25 | 12.17 | 311 | 52433 | 117188 | 34786999 |
Ureteral disorder | 40.73 | 12.17 | 14 | 52730 | 176 | 34904011 |
Toxic skin eruption | 40.04 | 12.17 | 66 | 52678 | 11319 | 34892868 |
Cardiac failure congestive | 39.93 | 12.17 | 40 | 52704 | 83230 | 34820957 |
Clostridium difficile infection | 39.72 | 12.17 | 88 | 52656 | 18810 | 34885377 |
Muscle spasms | 39.56 | 12.17 | 33 | 52711 | 74968 | 34829219 |
Inflammatory marker increased | 39.20 | 12.17 | 43 | 52701 | 4985 | 34899202 |
Diarrhoea | 38.36 | 12.17 | 390 | 52354 | 389522 | 34514665 |
Feeling abnormal | 36.98 | 12.17 | 25 | 52719 | 63210 | 34840977 |
COVID-19 pneumonia | 36.78 | 12.17 | 80 | 52664 | 16887 | 34887300 |
Cryptococcal meningoencephalitis | 36.77 | 12.17 | 12 | 52732 | 127 | 34904060 |
Portal fibrosis | 36.45 | 12.17 | 15 | 52729 | 318 | 34903869 |
Headache | 35.38 | 12.17 | 169 | 52575 | 200466 | 34703721 |
Dehydration | 35.34 | 12.17 | 91 | 52653 | 129878 | 34774309 |
Bacterial pericarditis | 35.33 | 12.17 | 10 | 52734 | 62 | 34904125 |
Thrombocytopenia | 34.99 | 12.17 | 375 | 52369 | 155872 | 34748315 |
Cardiac disorder | 34.54 | 12.17 | 11 | 52733 | 43115 | 34861072 |
Coronary artery disease | 34.20 | 12.17 | 15 | 52729 | 48290 | 34855897 |
Myasthenia gravis | 34.06 | 12.17 | 47 | 52697 | 6893 | 34897294 |
Encephalitis | 33.80 | 12.17 | 48 | 52696 | 7229 | 34896958 |
Intentional overdose | 33.49 | 12.17 | 12 | 52732 | 43662 | 34860525 |
Therapeutic product effect decreased | 33.44 | 12.17 | 6 | 52738 | 34737 | 34869450 |
Gait disturbance | 33.27 | 12.17 | 48 | 52696 | 85092 | 34819095 |
Liver function test increased | 33.10 | 12.17 | 70 | 52674 | 14495 | 34889692 |
Hepatitis fulminant | 32.95 | 12.17 | 36 | 52708 | 4154 | 34900033 |
Hepatitis toxic | 32.00 | 12.17 | 27 | 52717 | 2260 | 34901927 |
Weight decreased | 31.96 | 12.17 | 147 | 52597 | 176154 | 34728033 |
Leukocytosis | 31.76 | 12.17 | 94 | 52650 | 23971 | 34880216 |
Drug hypersensitivity | 31.61 | 12.17 | 219 | 52525 | 80310 | 34823877 |
Torsade de pointes | 31.22 | 12.17 | 46 | 52698 | 7163 | 34897024 |
Hepatitis acute | 30.78 | 12.17 | 47 | 52697 | 7554 | 34896633 |
Hepatitis cholestatic | 30.58 | 12.17 | 48 | 52696 | 7899 | 34896288 |
Malignant neoplasm progression | 30.29 | 12.17 | 54 | 52690 | 87992 | 34816195 |
Myasthenia gravis crisis | 30.20 | 12.17 | 16 | 52728 | 611 | 34903576 |
Blood uric acid increased | 30.15 | 12.17 | 53 | 52691 | 9571 | 34894616 |
Arthropathy | 29.80 | 12.17 | 3 | 52741 | 26904 | 34877283 |
Contusion | 29.62 | 12.17 | 9 | 52735 | 36355 | 34867832 |
Flank pain | 29.62 | 12.17 | 43 | 52701 | 6608 | 34897579 |
Urticaria | 29.61 | 12.17 | 178 | 52566 | 62199 | 34841988 |
Pruritus | 29.60 | 12.17 | 336 | 52408 | 141645 | 34762542 |
Choreoathetosis | 29.56 | 12.17 | 19 | 52725 | 1045 | 34903142 |
Drug resistance | 29.33 | 12.17 | 96 | 52648 | 25831 | 34878356 |
Hypoxia | 29.28 | 12.17 | 162 | 52582 | 54933 | 34849254 |
Pseudomembranous colitis | 29.26 | 12.17 | 28 | 52716 | 2763 | 34901424 |
Crying | 29.22 | 12.17 | 40 | 52704 | 5822 | 34898365 |
Chest pain | 29.18 | 12.17 | 96 | 52648 | 126666 | 34777521 |
Alcohol intolerance | 29.17 | 12.17 | 14 | 52730 | 432 | 34903755 |
Hyperferritinaemia | 29.11 | 12.17 | 14 | 52730 | 434 | 34903753 |
Malignant mesenteric neoplasm | 29.08 | 12.17 | 8 | 52736 | 44 | 34904143 |
Sphincter of Oddi dysfunction | 29.07 | 12.17 | 10 | 52734 | 126 | 34904061 |
Prostate cancer | 28.57 | 12.17 | 12 | 52732 | 39637 | 34864550 |
Crystalluria | 28.16 | 12.17 | 14 | 52730 | 467 | 34903720 |
Peripheral swelling | 28.12 | 12.17 | 45 | 52699 | 76496 | 34827691 |
Malaise | 28.02 | 12.17 | 165 | 52579 | 185660 | 34718527 |
Hepatic enzyme increased | 27.93 | 12.17 | 125 | 52619 | 38955 | 34865232 |
Escherichia infection | 27.92 | 12.17 | 47 | 52697 | 8198 | 34895989 |
Suicidal ideation | 27.88 | 12.17 | 13 | 52731 | 40375 | 34863812 |
Mycotic endophthalmitis | 27.86 | 12.17 | 9 | 52735 | 92 | 34904095 |
Acute hepatic failure | 27.86 | 12.17 | 64 | 52680 | 14010 | 34890177 |
Fixed eruption | 27.85 | 12.17 | 22 | 52722 | 1678 | 34902509 |
Respiratory distress | 27.72 | 12.17 | 117 | 52627 | 35548 | 34868639 |
Hypertension | 27.65 | 12.17 | 109 | 52635 | 136334 | 34767853 |
Hyper IgE syndrome | 27.56 | 12.17 | 8 | 52736 | 55 | 34904132 |
Blood pressure fluctuation | 27.48 | 12.17 | 3 | 52741 | 25246 | 34878941 |
Corynebacterium infection | 27.45 | 12.17 | 15 | 52729 | 610 | 34903577 |
Tachypnoea | 27.44 | 12.17 | 75 | 52669 | 18277 | 34885910 |
Wrong technique in product usage process | 27.40 | 12.17 | 10 | 52734 | 35976 | 34868211 |
Procalcitonin increased | 27.28 | 12.17 | 22 | 52722 | 1729 | 34902458 |
Hepatomegaly | 27.23 | 12.17 | 53 | 52691 | 10343 | 34893844 |
Cerebral cyst | 27.04 | 12.17 | 12 | 52732 | 308 | 34903879 |
Cheilitis | 27.01 | 12.17 | 25 | 52719 | 2366 | 34901821 |
Neuropathy peripheral | 26.94 | 12.17 | 53 | 52691 | 83210 | 34820977 |
Memory impairment | 26.87 | 12.17 | 16 | 52728 | 43302 | 34860885 |
Intervertebral discitis | 26.85 | 12.17 | 24 | 52720 | 2171 | 34902016 |
Device related sepsis | 26.84 | 12.17 | 28 | 52716 | 3065 | 34901122 |
Jaundice | 26.68 | 12.17 | 107 | 52637 | 31775 | 34872412 |
Enterobacter infection | 26.66 | 12.17 | 25 | 52719 | 2405 | 34901782 |
Dry gangrene | 26.36 | 12.17 | 13 | 52731 | 426 | 34903761 |
Back pain | 26.16 | 12.17 | 95 | 52649 | 121694 | 34782493 |
Syncope | 25.65 | 12.17 | 63 | 52681 | 91388 | 34812799 |
Janeway lesion | 25.49 | 12.17 | 6 | 52738 | 15 | 34904172 |
Blood pressure increased | 25.25 | 12.17 | 60 | 52684 | 88042 | 34816145 |
Balance disorder | 25.24 | 12.17 | 15 | 52729 | 40639 | 34863548 |
Cyanosis | 25.22 | 12.17 | 58 | 52686 | 12706 | 34891481 |
Drug effective for unapproved indication | 25.21 | 12.17 | 25 | 52719 | 2577 | 34901610 |
Drug interaction | 24.99 | 12.17 | 479 | 52265 | 225467 | 34678720 |
Vascular purpura | 24.90 | 12.17 | 21 | 52723 | 1757 | 34902430 |
Hyperphosphataemia | 24.76 | 12.17 | 32 | 52712 | 4405 | 34899782 |
Abdominal pain | 24.73 | 12.17 | 365 | 52379 | 163253 | 34740934 |
Aspartate aminotransferase increased | 24.66 | 12.17 | 181 | 52563 | 67602 | 34836585 |
Hepatic function abnormal | 24.61 | 12.17 | 132 | 52612 | 44231 | 34859956 |
Vision blurred | 24.51 | 12.17 | 20 | 52724 | 45943 | 34858244 |
Type IV hypersensitivity reaction | 24.45 | 12.17 | 19 | 52725 | 1415 | 34902772 |
Jejunal ulcer perforation | 24.40 | 12.17 | 8 | 52736 | 86 | 34904101 |
Metastases to stomach | 24.40 | 12.17 | 8 | 52736 | 86 | 34904101 |
Haemodynamic instability | 24.28 | 12.17 | 48 | 52696 | 9475 | 34894712 |
General physical health deterioration | 24.27 | 12.17 | 298 | 52446 | 127971 | 34776216 |
Shock | 24.25 | 12.17 | 86 | 52658 | 24093 | 34880094 |
Serum sickness-like reaction | 24.09 | 12.17 | 9 | 52735 | 146 | 34904041 |
Transient ischaemic attack | 24.05 | 12.17 | 6 | 52738 | 27607 | 34876580 |
Allergy test positive | 24.00 | 12.17 | 8 | 52736 | 91 | 34904096 |
Loss of personal independence in daily activities | 23.97 | 12.17 | 10 | 52734 | 33169 | 34871018 |
Incorrect dose administered | 23.70 | 12.17 | 16 | 52728 | 40499 | 34863688 |
Drug dependence | 23.70 | 12.17 | 4 | 52740 | 24213 | 34879974 |
Pleocytosis | 23.56 | 12.17 | 13 | 52731 | 539 | 34903648 |
Aspergillus infection | 23.46 | 12.17 | 55 | 52689 | 12199 | 34891988 |
Analgesic therapy | 23.32 | 12.17 | 16 | 52728 | 982 | 34903205 |
Endocarditis | 23.24 | 12.17 | 38 | 52706 | 6473 | 34897714 |
Drug eruption | 22.80 | 12.17 | 74 | 52670 | 19824 | 34884363 |
Dermatitis exfoliative generalised | 22.70 | 12.17 | 28 | 52716 | 3679 | 34900508 |
Systemic candida | 22.58 | 12.17 | 28 | 52716 | 3698 | 34900489 |
No adverse event | 22.53 | 12.17 | 81 | 52663 | 22846 | 34881341 |
Oliguria | 22.29 | 12.17 | 43 | 52701 | 8337 | 34895850 |
Omental necrosis | 22.28 | 12.17 | 6 | 52738 | 30 | 34904157 |
Cataract | 22.21 | 12.17 | 6 | 52738 | 26180 | 34878007 |
Acute respiratory failure | 22.15 | 12.17 | 99 | 52645 | 30829 | 34873358 |
Coagulopathy | 22.14 | 12.17 | 73 | 52671 | 19716 | 34884471 |
Injection site pain | 22.03 | 12.17 | 16 | 52728 | 38989 | 34865198 |
Procalcitonin abnormal | 22.02 | 12.17 | 11 | 52733 | 371 | 34903816 |
Infective chondritis | 22.01 | 12.17 | 5 | 52739 | 10 | 34904177 |
Blood alkaline phosphatase increased | 21.74 | 12.17 | 99 | 52645 | 31076 | 34873111 |
Dry skin | 21.70 | 12.17 | 10 | 52734 | 31277 | 34872910 |
Overdose | 21.61 | 12.17 | 68 | 52676 | 90991 | 34813196 |
Encephalopathy | 21.61 | 12.17 | 108 | 52636 | 35211 | 34868976 |
Hepatic cytolysis | 21.43 | 12.17 | 59 | 52685 | 14437 | 34889750 |
Drug therapy | 21.39 | 12.17 | 16 | 52728 | 1125 | 34903062 |
Bacterial parotitis | 21.37 | 12.17 | 6 | 52738 | 36 | 34904151 |
Intracranial pressure increased | 21.26 | 12.17 | 28 | 52716 | 3927 | 34900260 |
Cryptococcosis | 21.17 | 12.17 | 22 | 52722 | 2397 | 34901790 |
Erectile dysfunction | 21.13 | 12.17 | 3 | 52741 | 20634 | 34883553 |
Malabsorption from administration site | 20.97 | 12.17 | 7 | 52737 | 80 | 34904107 |
Eastern Cooperative Oncology Group performance status | 20.96 | 12.17 | 6 | 52738 | 39 | 34904148 |
Tissue infiltration | 20.89 | 12.17 | 7 | 52737 | 81 | 34904106 |
Coagulation factor decreased | 20.66 | 12.17 | 7 | 52737 | 84 | 34904103 |
Dyspnoea | 20.65 | 12.17 | 423 | 52321 | 376359 | 34527828 |
Psoriasis | 20.55 | 12.17 | 17 | 52727 | 38795 | 34865392 |
Red blood cell schistocytes present | 20.10 | 12.17 | 9 | 52735 | 236 | 34903951 |
Liver transplant failure | 20.08 | 12.17 | 7 | 52737 | 92 | 34904095 |
Orthostatic hypotension | 20.07 | 12.17 | 7 | 52737 | 25912 | 34878275 |
Stenotrophomonas infection | 19.94 | 12.17 | 20 | 52724 | 2090 | 34902097 |
Splenomegaly | 19.89 | 12.17 | 59 | 52685 | 15058 | 34889129 |
Neurotoxicity | 19.76 | 12.17 | 66 | 52678 | 17944 | 34886243 |
Muscle abscess | 19.56 | 12.17 | 12 | 52732 | 608 | 34903579 |
Antinuclear antibody negative | 19.47 | 12.17 | 5 | 52739 | 20 | 34904167 |
Antimicrobial susceptibility test resistant | 19.31 | 12.17 | 10 | 52734 | 364 | 34903823 |
Amnesia | 19.20 | 12.17 | 8 | 52736 | 26555 | 34877632 |
Hypoaesthesia | 19.11 | 12.17 | 40 | 52704 | 61404 | 34842783 |
Neutropenia | 18.92 | 12.17 | 337 | 52407 | 156441 | 34747746 |
Pulmonary physical examination abnormal | 18.91 | 12.17 | 5 | 52739 | 23 | 34904164 |
Shock haemorrhagic | 18.60 | 12.17 | 48 | 52696 | 11306 | 34892881 |
Neoplasm progression | 18.56 | 12.17 | 6 | 52738 | 23294 | 34880893 |
Sleep apnoea syndrome | 18.52 | 12.17 | 4 | 52740 | 20317 | 34883870 |
Faeces pale | 18.48 | 12.17 | 16 | 52728 | 1387 | 34902800 |
Vanishing bile duct syndrome | 18.48 | 12.17 | 14 | 52730 | 1004 | 34903183 |
Erythema | 18.43 | 12.17 | 210 | 52534 | 88570 | 34815617 |
Gastrooesophageal reflux disease | 18.42 | 12.17 | 18 | 52726 | 37906 | 34866281 |
Sleep disorder therapy | 18.42 | 12.17 | 14 | 52730 | 1009 | 34903178 |
Bile duct stone | 18.31 | 12.17 | 21 | 52723 | 2556 | 34901631 |
Arteriospasm coronary | 18.26 | 12.17 | 24 | 52720 | 3358 | 34900829 |
Contraindicated product administered | 18.07 | 12.17 | 5 | 52739 | 21476 | 34882711 |
Antibiotic level below therapeutic | 18.02 | 12.17 | 6 | 52738 | 68 | 34904119 |
Low birth weight baby | 17.97 | 12.17 | 38 | 52706 | 7867 | 34896320 |
Vitamin A deficiency | 17.95 | 12.17 | 5 | 52739 | 29 | 34904158 |
Basal cell carcinoma | 17.65 | 12.17 | 4 | 52740 | 19654 | 34884533 |
Unevaluable event | 17.60 | 12.17 | 14 | 52730 | 32576 | 34871611 |
Interleukin-2 receptor increased | 17.57 | 12.17 | 7 | 52737 | 136 | 34904051 |
Influenza | 17.49 | 12.17 | 30 | 52714 | 49636 | 34854551 |
Haemophagocytic lymphohistiocytosis | 17.42 | 12.17 | 51 | 52693 | 12922 | 34891265 |
Suicide attempt | 17.39 | 12.17 | 20 | 52724 | 39096 | 34865091 |
Peritoneal dialysis | 17.34 | 12.17 | 11 | 52733 | 591 | 34903596 |
Decreased appetite | 17.30 | 12.17 | 164 | 52580 | 166228 | 34737959 |
Abdominal compartment syndrome | 17.06 | 12.17 | 13 | 52731 | 940 | 34903247 |
White blood cell count decreased | 17.02 | 12.17 | 80 | 52664 | 95365 | 34808822 |
Irritability | 16.96 | 12.17 | 8 | 52736 | 24682 | 34879505 |
Altered state of consciousness | 16.94 | 12.17 | 74 | 52670 | 22819 | 34881368 |
Musculoskeletal pain | 16.92 | 12.17 | 14 | 52730 | 31949 | 34872238 |
Gamma-glutamyltransferase increased | 16.91 | 12.17 | 88 | 52656 | 29143 | 34875044 |
Hyperamylasaemia | 16.89 | 12.17 | 11 | 52733 | 619 | 34903568 |
Cardiac ventricular thrombosis | 16.86 | 12.17 | 14 | 52730 | 1146 | 34903041 |
Osteomyelitis fungal | 16.72 | 12.17 | 8 | 52736 | 245 | 34903942 |
Erythema nodosum | 16.57 | 12.17 | 15 | 52729 | 1379 | 34902808 |
ADAMTS13 activity decreased | 16.55 | 12.17 | 6 | 52738 | 89 | 34904098 |
Infective spondylitis | 16.54 | 12.17 | 8 | 52736 | 251 | 34903936 |
Bronchopleural fistula | 16.54 | 12.17 | 10 | 52734 | 493 | 34903694 |
Calculus urinary | 16.45 | 12.17 | 15 | 52729 | 1392 | 34902795 |
Renal papillary necrosis | 16.32 | 12.17 | 7 | 52737 | 165 | 34904022 |
Morganella infection | 16.20 | 12.17 | 10 | 52734 | 512 | 34903675 |
Cerebellar syndrome | 16.20 | 12.17 | 19 | 52725 | 2369 | 34901818 |
Mobility decreased | 16.19 | 12.17 | 13 | 52731 | 30115 | 34874072 |
Face oedema | 16.17 | 12.17 | 46 | 52698 | 11470 | 34892717 |
Prothrombin time ratio decreased | 16.16 | 12.17 | 9 | 52735 | 380 | 34903807 |
Dysgeusia | 16.13 | 12.17 | 10 | 52734 | 26487 | 34877700 |
Encephalomalacia | 16.02 | 12.17 | 12 | 52732 | 846 | 34903341 |
Hypofibrinogenaemia | 15.97 | 12.17 | 16 | 52728 | 1670 | 34902517 |
Palmar-plantar erythrodysaesthesia syndrome | 15.94 | 12.17 | 3 | 52741 | 16792 | 34887395 |
Cholecystitis acute | 15.87 | 12.17 | 32 | 52712 | 6407 | 34897780 |
Erythema multiforme | 15.67 | 12.17 | 38 | 52706 | 8611 | 34895576 |
Carotid artery insufficiency | 15.58 | 12.17 | 4 | 52740 | 16 | 34904171 |
Arterial angioplasty | 15.58 | 12.17 | 5 | 52739 | 50 | 34904137 |
Chondrocalcinosis | 15.56 | 12.17 | 9 | 52735 | 409 | 34903778 |
Disturbance in attention | 15.51 | 12.17 | 10 | 52734 | 25935 | 34878252 |
Type IIa hyperlipidaemia | 15.38 | 12.17 | 7 | 52737 | 191 | 34903996 |
Herpes zoster reactivation | 15.36 | 12.17 | 8 | 52736 | 295 | 34903892 |
Human T-cell lymphotropic virus type I infection | 15.20 | 12.17 | 4 | 52740 | 18 | 34904169 |
Palpitations | 15.17 | 12.17 | 23 | 52721 | 39963 | 34864224 |
Alopecia | 15.09 | 12.17 | 9 | 52735 | 24346 | 34879841 |
Fungaemia | 15.09 | 12.17 | 19 | 52725 | 2549 | 34901638 |
Epileptic encephalopathy | 15.05 | 12.17 | 7 | 52737 | 201 | 34903986 |
Vomiting | 15.02 | 12.17 | 484 | 52260 | 247137 | 34657050 |
Discomfort | 14.86 | 12.17 | 5 | 52739 | 18933 | 34885254 |
Tuberculosis of genitourinary system | 14.86 | 12.17 | 4 | 52740 | 20 | 34904167 |
Asthma | 14.81 | 12.17 | 26 | 52718 | 42630 | 34861557 |
Iron deficiency | 14.79 | 12.17 | 28 | 52716 | 5353 | 34898834 |
Influenza like illness | 14.76 | 12.17 | 12 | 52732 | 27622 | 34876565 |
Rash | 14.73 | 12.17 | 440 | 52304 | 222312 | 34681875 |
Red blood cell sedimentation rate decreased | 14.68 | 12.17 | 5 | 52739 | 61 | 34904126 |
Pancytopenia | 14.64 | 12.17 | 213 | 52531 | 94944 | 34809243 |
Glucose-6-phosphate dehydrogenase deficiency | 14.55 | 12.17 | 6 | 52738 | 128 | 34904059 |
Full blood count abnormal | 14.53 | 12.17 | 5 | 52739 | 18663 | 34885524 |
Cholangitis | 14.50 | 12.17 | 37 | 52707 | 8652 | 34895535 |
Dyspnoea exertional | 14.47 | 12.17 | 27 | 52717 | 43252 | 34860935 |
Delusion of parasitosis | 14.42 | 12.17 | 3 | 52741 | 3 | 34904184 |
Pneumonia bacterial | 14.37 | 12.17 | 45 | 52699 | 11827 | 34892360 |
Heart rate decreased | 14.36 | 12.17 | 16 | 52728 | 31729 | 34872458 |
Henoch-Schonlein purpura | 14.34 | 12.17 | 15 | 52729 | 1647 | 34902540 |
Drug withdrawal syndrome | 14.29 | 12.17 | 6 | 52738 | 19828 | 34884359 |
Strongyloidiasis | 14.27 | 12.17 | 19 | 52725 | 2692 | 34901495 |
Incorrect route of product administration | 14.20 | 12.17 | 52 | 52692 | 14793 | 34889394 |
Premature baby | 14.17 | 12.17 | 63 | 52681 | 19570 | 34884617 |
Coagulation factor V level decreased | 14.09 | 12.17 | 7 | 52737 | 233 | 34903954 |
Delirium | 14.06 | 12.17 | 114 | 52630 | 43877 | 34860310 |
Hypercreatininaemia | 14.05 | 12.17 | 9 | 52735 | 492 | 34903695 |
Therapeutic product effect incomplete | 14.02 | 12.17 | 35 | 52709 | 50506 | 34853681 |
Listeriosis | 14.00 | 12.17 | 12 | 52732 | 1026 | 34903161 |
Fluid retention | 13.96 | 12.17 | 12 | 52732 | 26875 | 34877312 |
Psychotic disorder | 13.85 | 12.17 | 10 | 52734 | 24442 | 34879745 |
Gait inability | 13.84 | 12.17 | 7 | 52737 | 20751 | 34883436 |
Metastases to heart | 13.70 | 12.17 | 6 | 52738 | 149 | 34904038 |
Meningitis candida | 13.68 | 12.17 | 5 | 52739 | 76 | 34904111 |
Status epilepticus | 13.63 | 12.17 | 46 | 52698 | 12568 | 34891619 |
Colitis ulcerative | 13.61 | 12.17 | 4 | 52740 | 16516 | 34887671 |
Ocular icterus | 13.50 | 12.17 | 19 | 52725 | 2838 | 34901349 |
Meningitis bacterial | 13.49 | 12.17 | 13 | 52731 | 1294 | 34902893 |
Osteonecrosis | 13.43 | 12.17 | 3 | 52741 | 14887 | 34889300 |
Bronchial haemorrhage | 13.42 | 12.17 | 10 | 52734 | 699 | 34903488 |
Purpura | 13.34 | 12.17 | 40 | 52704 | 10271 | 34893916 |
PO2 decreased | 13.16 | 12.17 | 14 | 52730 | 1567 | 34902620 |
Cell death | 13.15 | 12.17 | 17 | 52727 | 2340 | 34901847 |
Tremor | 13.14 | 12.17 | 72 | 52672 | 82515 | 34821672 |
Adverse event | 13.14 | 12.17 | 6 | 52738 | 18871 | 34885316 |
COVID-19 treatment | 13.12 | 12.17 | 7 | 52737 | 271 | 34903916 |
Administration site reaction | 13.11 | 12.17 | 5 | 52739 | 86 | 34904101 |
Dyspepsia | 13.11 | 12.17 | 22 | 52722 | 36710 | 34867477 |
Empyema | 13.09 | 12.17 | 20 | 52724 | 3216 | 34900971 |
Migraine | 13.06 | 12.17 | 5 | 52739 | 17473 | 34886714 |
Rash erythematous | 12.96 | 12.17 | 73 | 52671 | 24904 | 34879283 |
Neuroborreliosis | 12.94 | 12.17 | 4 | 52740 | 35 | 34904152 |
Flatulence | 12.90 | 12.17 | 8 | 52736 | 21190 | 34882997 |
Enterococcal infection | 12.90 | 12.17 | 37 | 52707 | 9269 | 34894918 |
Hypocoagulable state | 12.89 | 12.17 | 11 | 52733 | 935 | 34903252 |
Injection site erythema | 12.83 | 12.17 | 4 | 52740 | 15895 | 34888292 |
Cardiac arrest | 12.78 | 12.17 | 210 | 52534 | 95949 | 34808238 |
Hyperthermia | 12.72 | 12.17 | 40 | 52704 | 10537 | 34893650 |
Pollakiuria | 12.58 | 12.17 | 7 | 52737 | 19667 | 34884520 |
Surgery | 12.48 | 12.17 | 3 | 52741 | 14154 | 34890033 |
Urticarial vasculitis | 12.46 | 12.17 | 4 | 52740 | 40 | 34904147 |
Chorioretinitis | 12.40 | 12.17 | 8 | 52736 | 443 | 34903744 |
Fibrous dysplasia of bone | 12.35 | 12.17 | 3 | 52741 | 9 | 34904178 |
Head injury | 12.29 | 12.17 | 6 | 52738 | 18154 | 34886033 |
Ischaemic limb pain | 12.29 | 12.17 | 4 | 52740 | 42 | 34904145 |
Ureteric obstruction | 12.27 | 12.17 | 12 | 52732 | 1216 | 34902971 |
Haematuria traumatic | 12.27 | 12.17 | 6 | 52738 | 193 | 34903994 |
Visual impairment | 12.27 | 12.17 | 22 | 52722 | 35780 | 34868407 |
Urinary tract infection fungal | 12.24 | 12.17 | 8 | 52736 | 453 | 34903734 |
SJS-TEN overlap | 12.20 | 12.17 | 7 | 52737 | 313 | 34903874 |
Lower respiratory tract infection | 12.19 | 12.17 | 18 | 52726 | 31619 | 34872568 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug reaction with eosinophilia and systemic symptoms | 1098.89 | 11.22 | 774 | 93837 | 63470 | 79586307 |
Off label use | 719.09 | 11.22 | 2529 | 92082 | 904686 | 78745091 |
Pseudocholelithiasis | 532.68 | 11.22 | 94 | 94517 | 7 | 79649770 |
Acute generalised exanthematous pustulosis | 486.39 | 11.22 | 285 | 94326 | 16969 | 79632808 |
Acute kidney injury | 471.99 | 11.22 | 1519 | 93092 | 517885 | 79131892 |
Rash maculo-papular | 441.52 | 11.22 | 431 | 94180 | 55647 | 79594130 |
Eosinophilia | 427.06 | 11.22 | 385 | 94226 | 44960 | 79604817 |
Multiple organ dysfunction syndrome | 423.05 | 11.22 | 612 | 93999 | 119634 | 79530143 |
Toxic epidermal necrolysis | 405.12 | 11.22 | 371 | 94240 | 44210 | 79605567 |
Fatigue | 391.57 | 11.22 | 319 | 94292 | 929408 | 78720369 |
Postrenal failure | 388.12 | 11.22 | 101 | 94510 | 576 | 79649201 |
Jarisch-Herxheimer reaction | 376.06 | 11.22 | 106 | 94505 | 851 | 79648926 |
Pain | 297.66 | 11.22 | 240 | 94371 | 703562 | 78946215 |
Agranulocytosis | 295.92 | 11.22 | 314 | 94297 | 44716 | 79605061 |
Cholelithiasis | 285.39 | 11.22 | 332 | 94279 | 52332 | 79597445 |
Cholestasis | 278.21 | 11.22 | 326 | 94285 | 51783 | 79597994 |
Completed suicide | 270.87 | 11.22 | 4 | 94607 | 245763 | 79404014 |
Appendicolith | 266.99 | 11.22 | 151 | 94460 | 8400 | 79641377 |
Joint swelling | 266.20 | 11.22 | 20 | 94591 | 288626 | 79361151 |
Clostridium test positive | 265.90 | 11.22 | 137 | 94474 | 6317 | 79643460 |
Clostridium difficile colitis | 246.34 | 11.22 | 244 | 94367 | 32039 | 79617738 |
Hepatocellular injury | 238.00 | 11.22 | 288 | 94323 | 47305 | 79602472 |
Hepatitis | 233.88 | 11.22 | 309 | 94302 | 55418 | 79594359 |
Septic shock | 226.73 | 11.22 | 470 | 94141 | 122331 | 79527446 |
Arthralgia | 215.19 | 11.22 | 217 | 94394 | 571586 | 79078191 |
Haemolytic anaemia | 214.02 | 11.22 | 174 | 94437 | 17646 | 79632131 |
Pyrexia | 210.92 | 11.22 | 1451 | 93160 | 677258 | 78972519 |
Anaphylactic shock | 210.34 | 11.22 | 236 | 94375 | 35760 | 79614017 |
Rheumatoid arthritis | 202.39 | 11.22 | 11 | 94600 | 208459 | 79441318 |
Drug ineffective for unapproved indication | 195.09 | 11.22 | 271 | 94340 | 50967 | 79598810 |
Cardiogenic shock | 194.03 | 11.22 | 244 | 94367 | 41670 | 79608107 |
Appendicitis | 192.65 | 11.22 | 175 | 94436 | 20619 | 79629158 |
Factor V inhibition | 190.48 | 11.22 | 51 | 94560 | 330 | 79649447 |
Electrocardiogram QT prolonged | 188.44 | 11.22 | 364 | 94247 | 90022 | 79559755 |
Arthropathy | 186.66 | 11.22 | 5 | 94606 | 177106 | 79472671 |
Respiratory failure | 182.77 | 11.22 | 550 | 94061 | 180361 | 79469416 |
Fall | 181.15 | 11.22 | 187 | 94424 | 487442 | 79162335 |
Toxic encephalopathy | 179.64 | 11.22 | 131 | 94480 | 11309 | 79638468 |
Weight increased | 177.90 | 11.22 | 54 | 94557 | 277332 | 79372445 |
Abdominal discomfort | 177.56 | 11.22 | 40 | 94571 | 250687 | 79399090 |
Headache | 175.22 | 11.22 | 318 | 94293 | 653454 | 78996323 |
Dizziness | 174.85 | 11.22 | 221 | 94390 | 526220 | 79123557 |
Alopecia | 171.89 | 11.22 | 33 | 94578 | 231322 | 79418455 |
Synovitis | 163.74 | 11.22 | 3 | 94608 | 150731 | 79499046 |
Product dose omission issue | 159.06 | 11.22 | 48 | 94563 | 247489 | 79402288 |
Stevens-Johnson syndrome | 157.91 | 11.22 | 213 | 94398 | 38953 | 79610824 |
Drug-induced liver injury | 156.21 | 11.22 | 281 | 94330 | 65836 | 79583941 |
Therapeutic product effect decreased | 154.92 | 11.22 | 10 | 94601 | 163853 | 79485924 |
Bronchopulmonary aspergillosis | 152.73 | 11.22 | 159 | 94452 | 22135 | 79627642 |
Nasopharyngitis | 151.31 | 11.22 | 56 | 94555 | 253825 | 79395952 |
Tubulointerstitial nephritis | 149.70 | 11.22 | 205 | 94406 | 38030 | 79611747 |
Drug interaction | 145.78 | 11.22 | 916 | 93695 | 414267 | 79235510 |
Pain in extremity | 141.96 | 11.22 | 134 | 94477 | 364404 | 79285373 |
Drug intolerance | 140.26 | 11.22 | 69 | 94542 | 264050 | 79385727 |
Pathogen resistance | 139.36 | 11.22 | 124 | 94487 | 14218 | 79635559 |
Peripheral swelling | 139.35 | 11.22 | 73 | 94538 | 269544 | 79380233 |
Sepsis | 138.77 | 11.22 | 660 | 93951 | 268768 | 79381009 |
Ventricular fibrillation | 138.53 | 11.22 | 180 | 94431 | 31746 | 79618031 |
Long QT syndrome | 136.03 | 11.22 | 86 | 94525 | 5869 | 79643908 |
Hypertransaminasaemia | 136 | 11.22 | 113 | 94498 | 11811 | 79637966 |
Premature delivery | 130.54 | 11.22 | 150 | 94461 | 23317 | 79626460 |
Drug abuse | 127.84 | 11.22 | 20 | 94591 | 162671 | 79487106 |
Contraindicated product administered | 126.93 | 11.22 | 18 | 94593 | 157520 | 79492257 |
Acute respiratory distress syndrome | 120.73 | 11.22 | 200 | 94411 | 43867 | 79605910 |
Leukocytosis | 118.75 | 11.22 | 197 | 94414 | 43258 | 79606519 |
Insomnia | 117.21 | 11.22 | 73 | 94538 | 245097 | 79404680 |
Contusion | 115.29 | 11.22 | 19 | 94592 | 148757 | 79501020 |
Anaphylactic reaction | 114.87 | 11.22 | 285 | 94326 | 83458 | 79566319 |
Status epilepticus | 114.64 | 11.22 | 145 | 94466 | 24896 | 79624881 |
Clostridium difficile infection | 111.97 | 11.22 | 190 | 94421 | 42495 | 79607282 |
Depression | 111.55 | 11.22 | 59 | 94552 | 216731 | 79433046 |
Immune reconstitution inflammatory syndrome | 110.01 | 11.22 | 107 | 94504 | 13734 | 79636043 |
Hydronephrosis | 108.10 | 11.22 | 118 | 94493 | 17336 | 79632441 |
Thrombocytopenia | 107.55 | 11.22 | 608 | 94003 | 264651 | 79385126 |
Transaminases increased | 106.11 | 11.22 | 207 | 94404 | 51536 | 79598241 |
Ureterolithiasis | 101.72 | 11.22 | 61 | 94550 | 3787 | 79645990 |
Glossodynia | 101.68 | 11.22 | 5 | 94606 | 103332 | 79546445 |
Kounis syndrome | 100.72 | 11.22 | 63 | 94548 | 4219 | 79645558 |
Hepatitis cholestatic | 100.68 | 11.22 | 102 | 94509 | 13750 | 79636027 |
Pseudomembranous colitis | 99.35 | 11.22 | 68 | 94543 | 5306 | 79644471 |
Wound | 99.11 | 11.22 | 11 | 94600 | 116168 | 79533609 |
Haemolysis | 98.01 | 11.22 | 97 | 94514 | 12715 | 79637062 |
Malaise | 97.19 | 11.22 | 280 | 94331 | 489589 | 79160188 |
Encephalopathy | 96.28 | 11.22 | 233 | 94378 | 67164 | 79582613 |
Pemphigus | 94.33 | 11.22 | 6 | 94605 | 99576 | 79550201 |
Injection site pain | 93.31 | 11.22 | 20 | 94591 | 129818 | 79519959 |
Systemic lupus erythematosus | 92.70 | 11.22 | 16 | 94595 | 121133 | 79528644 |
Sinusitis | 92.34 | 11.22 | 59 | 94552 | 195442 | 79454335 |
Death | 89.78 | 11.22 | 357 | 94254 | 566157 | 79083620 |
Muscle spasms | 87.76 | 11.22 | 49 | 94562 | 174681 | 79475096 |
Ascites | 87.09 | 11.22 | 241 | 94370 | 75321 | 79574456 |
Discomfort | 86.97 | 11.22 | 21 | 94590 | 125596 | 79524181 |
Blood phosphorus increased | 86.03 | 11.22 | 82 | 94529 | 10265 | 79639512 |
Tachypnoea | 84.46 | 11.22 | 143 | 94468 | 31920 | 79617857 |
Rash morbilliform | 82.29 | 11.22 | 64 | 94547 | 6086 | 79643691 |
Gait disturbance | 82.20 | 11.22 | 75 | 94536 | 207431 | 79442346 |
Pleocytosis | 81.62 | 11.22 | 38 | 94573 | 1401 | 79648376 |
Klebsiella infection | 79.98 | 11.22 | 96 | 94515 | 15624 | 79634153 |
Encephalitis | 79.83 | 11.22 | 93 | 94518 | 14667 | 79635110 |
Musculoskeletal stiffness | 79.69 | 11.22 | 55 | 94556 | 174953 | 79474824 |
Toxicity to various agents | 78.51 | 11.22 | 248 | 94363 | 421292 | 79228485 |
Choreoathetosis | 78.46 | 11.22 | 38 | 94573 | 1532 | 79648245 |
Cross sensitivity reaction | 78.33 | 11.22 | 51 | 94560 | 3661 | 79646116 |
Neutropenia | 76.75 | 11.22 | 594 | 94017 | 287116 | 79362661 |
Exposure during pregnancy | 76.55 | 11.22 | 279 | 94332 | 100853 | 79548924 |
Mobility decreased | 76.09 | 11.22 | 25 | 94586 | 122150 | 79527627 |
Alanine aminotransferase increased | 75.57 | 11.22 | 387 | 94224 | 162183 | 79487594 |
Hypoxia | 74.94 | 11.22 | 281 | 94330 | 102962 | 79546815 |
Swelling | 74.91 | 11.22 | 88 | 94523 | 216623 | 79433154 |
Drug ineffective | 74.79 | 11.22 | 1741 | 92870 | 1079172 | 78570605 |
Nocardiosis | 73.61 | 11.22 | 58 | 94553 | 5621 | 79644156 |
Cardiac arrest | 73.37 | 11.22 | 400 | 94211 | 171696 | 79478081 |
Drug resistance | 72.53 | 11.22 | 157 | 94454 | 42056 | 79607721 |
Disseminated intravascular coagulation | 71.79 | 11.22 | 142 | 94469 | 35700 | 79614077 |
Anxiety | 70.80 | 11.22 | 116 | 94495 | 248396 | 79401381 |
Altered state of consciousness | 70.79 | 11.22 | 159 | 94452 | 43663 | 79606114 |
Weight decreased | 70.40 | 11.22 | 203 | 94408 | 354995 | 79294782 |
Hypertension | 69.44 | 11.22 | 184 | 94427 | 330808 | 79318969 |
Enterococcal infection | 69.03 | 11.22 | 89 | 94522 | 15571 | 79634206 |
Infusion related reaction | 68.88 | 11.22 | 104 | 94507 | 230133 | 79419644 |
Anuria | 68.27 | 11.22 | 103 | 94508 | 20860 | 79628917 |
Toxic skin eruption | 67.63 | 11.22 | 106 | 94505 | 22187 | 79627590 |
Intentional overdose | 67.19 | 11.22 | 21 | 94590 | 105939 | 79543838 |
Respiratory distress | 67.15 | 11.22 | 186 | 94425 | 58153 | 79591624 |
Urticaria | 66.92 | 11.22 | 412 | 94199 | 184789 | 79464988 |
Lower respiratory tract infection | 66.69 | 11.22 | 35 | 94576 | 129185 | 79520592 |
Product use in unapproved indication | 66.26 | 11.22 | 516 | 94095 | 249843 | 79399934 |
Hypoaesthesia | 66.19 | 11.22 | 69 | 94542 | 179283 | 79470494 |
Pneumococcal infection | 66.08 | 11.22 | 29 | 94582 | 929 | 79648848 |
Brain abscess | 65.25 | 11.22 | 51 | 94560 | 4885 | 79644892 |
Haemophagocytic lymphohistiocytosis | 65.10 | 11.22 | 103 | 94508 | 21734 | 79628043 |
Ear pruritus | 64.33 | 11.22 | 47 | 94564 | 4068 | 79645709 |
Migraine | 63.84 | 11.22 | 13 | 94598 | 87480 | 79562297 |
Torsade de pointes | 63.05 | 11.22 | 95 | 94516 | 19217 | 79630560 |
Myasthenia gravis crisis | 61.96 | 11.22 | 29 | 94582 | 1082 | 79648695 |
Musculoskeletal pain | 61.90 | 11.22 | 22 | 94589 | 102332 | 79547445 |
Trichosporon infection | 61.49 | 11.22 | 28 | 94583 | 980 | 79648797 |
Myocardial infarction | 61.27 | 11.22 | 77 | 94534 | 184052 | 79465725 |
Helicobacter infection | 60.99 | 11.22 | 6 | 94605 | 69698 | 79580079 |
Mucormycosis | 60.89 | 11.22 | 62 | 94549 | 8407 | 79641370 |
Erythema | 60.62 | 11.22 | 463 | 94148 | 222827 | 79426950 |
Injection site erythema | 60.54 | 11.22 | 10 | 94601 | 78187 | 79571590 |
COVID-19 pneumonia | 59.85 | 11.22 | 116 | 94495 | 28733 | 79621044 |
Condition aggravated | 59.65 | 11.22 | 879 | 93732 | 500245 | 79149532 |
Abdominal pain upper | 59.62 | 11.22 | 109 | 94502 | 223710 | 79426067 |
Inappropriate schedule of product administration | 59.50 | 11.22 | 43 | 94568 | 133585 | 79516192 |
Shock | 59.47 | 11.22 | 148 | 94463 | 43400 | 79606377 |
Feeling abnormal | 59.02 | 11.22 | 61 | 94550 | 159138 | 79490639 |
Hyponatraemia | 58.90 | 11.22 | 387 | 94224 | 177461 | 79472316 |
Pericarditis | 58.75 | 11.22 | 25 | 94586 | 104211 | 79545566 |
Blood pressure fluctuation | 58.18 | 11.22 | 6 | 94605 | 67139 | 79582638 |
Stomatitis | 58.15 | 11.22 | 53 | 94558 | 146704 | 79503073 |
Osteoarthritis | 57.74 | 11.22 | 16 | 94595 | 87293 | 79562484 |
Pulmonary function test abnormal | 57.35 | 11.22 | 44 | 94567 | 4100 | 79645677 |
Hepatic cytolysis | 57.34 | 11.22 | 110 | 94501 | 27041 | 79622736 |
Back pain | 57.26 | 11.22 | 178 | 94433 | 304002 | 79345775 |
Chest X-ray abnormal | 57.20 | 11.22 | 58 | 94553 | 7825 | 79641952 |
Blood pressure increased | 57.13 | 11.22 | 102 | 94509 | 211258 | 79438519 |
Ill-defined disorder | 56.78 | 11.22 | 6 | 94605 | 65869 | 79583908 |
Stenotrophomonas infection | 56.52 | 11.22 | 42 | 94569 | 3731 | 79646046 |
Linear IgA disease | 56.41 | 11.22 | 39 | 94572 | 3093 | 79646684 |
Haemodynamic instability | 56.03 | 11.22 | 85 | 94526 | 17297 | 79632480 |
Blood lactic acid increased | 55.50 | 11.22 | 72 | 94539 | 12672 | 79637105 |
Cholangitis | 55.36 | 11.22 | 72 | 94539 | 12704 | 79637073 |
Balance disorder | 55.26 | 11.22 | 24 | 94587 | 98833 | 79550944 |
Fibromyalgia | 55.10 | 11.22 | 6 | 94605 | 64334 | 79585443 |
Psoriatic arthropathy | 54.06 | 11.22 | 13 | 94598 | 77986 | 79571791 |
Enterobacter infection | 53.62 | 11.22 | 44 | 94567 | 4518 | 79645259 |
Nausea | 52.50 | 11.22 | 810 | 93801 | 956386 | 78693391 |
Inflammatory marker increased | 52.05 | 11.22 | 64 | 94547 | 10676 | 79639101 |
Cyanosis | 51.93 | 11.22 | 101 | 94510 | 25081 | 79624696 |
Psoriasis | 51.27 | 11.22 | 21 | 94590 | 89566 | 79560211 |
Folliculitis | 50.53 | 11.22 | 4 | 94607 | 55376 | 79594401 |
Dermatitis exfoliative generalised | 50.23 | 11.22 | 52 | 94559 | 7189 | 79642588 |
Hepatitis acute | 50.09 | 11.22 | 76 | 94535 | 15466 | 79634311 |
Injection site reaction | 49.87 | 11.22 | 4 | 94607 | 54781 | 79594996 |
Memory impairment | 49.69 | 11.22 | 36 | 94575 | 111698 | 79538079 |
Escherichia infection | 49.64 | 11.22 | 82 | 94529 | 17935 | 79631842 |
Hospitalisation | 49.40 | 11.22 | 25 | 94586 | 94211 | 79555566 |
Dermatitis bullous | 49.27 | 11.22 | 72 | 94539 | 14173 | 79635604 |
Hepatic function abnormal | 48.97 | 11.22 | 194 | 94417 | 72913 | 79576864 |
Arthritis | 48.55 | 11.22 | 39 | 94572 | 114841 | 79534936 |
Jaundice | 48.06 | 11.22 | 156 | 94455 | 53193 | 79596584 |
Endocarditis | 47.93 | 11.22 | 61 | 94550 | 10536 | 79639241 |
Intervertebral discitis | 47.41 | 11.22 | 42 | 94569 | 4786 | 79644991 |
Pancytopenia | 47.41 | 11.22 | 348 | 94263 | 165397 | 79484380 |
Oliguria | 47.34 | 11.22 | 76 | 94535 | 16233 | 79633544 |
Dyspepsia | 47.06 | 11.22 | 36 | 94575 | 108651 | 79541126 |
Neurotoxicity | 47.05 | 11.22 | 113 | 94498 | 32405 | 79617372 |
Dermatitis exfoliative | 46.88 | 11.22 | 61 | 94550 | 10768 | 79639009 |
Palpitations | 46.38 | 11.22 | 49 | 94562 | 126561 | 79523216 |
Symmetrical drug-related intertriginous and flexural exanthema | 45.96 | 11.22 | 22 | 94589 | 864 | 79648913 |
Bile duct stone | 45.91 | 11.22 | 44 | 94567 | 5545 | 79644232 |
Cataract | 45.80 | 11.22 | 9 | 94602 | 62111 | 79587666 |
Leukopenia | 45.78 | 11.22 | 265 | 94346 | 116248 | 79533529 |
C-reactive protein abnormal | 45.55 | 11.22 | 3 | 94608 | 48364 | 79601413 |
Aspartate aminotransferase increased | 45.47 | 11.22 | 301 | 94310 | 138340 | 79511437 |
Candida infection | 45.13 | 11.22 | 123 | 94488 | 38091 | 79611686 |
Renal failure | 45.00 | 11.22 | 399 | 94212 | 200569 | 79449208 |
Type 2 diabetes mellitus | 44.90 | 11.22 | 7 | 94604 | 57115 | 79592662 |
Acute respiratory failure | 44.82 | 11.22 | 164 | 94447 | 59377 | 79590400 |
Myasthenia gravis | 44.12 | 11.22 | 58 | 94553 | 10341 | 79639436 |
Acinetobacter infection | 44.05 | 11.22 | 32 | 94579 | 2745 | 79647032 |
Aspergillus infection | 43.41 | 11.22 | 80 | 94531 | 19081 | 79630696 |
Type IV hypersensitivity reaction | 43.09 | 11.22 | 37 | 94574 | 4044 | 79645733 |
Fixed eruption | 42.28 | 11.22 | 32 | 94579 | 2922 | 79646855 |
Metabolic acidosis | 42.26 | 11.22 | 202 | 94409 | 82327 | 79567450 |
Cholecystitis | 42.09 | 11.22 | 86 | 94525 | 22126 | 79627651 |
Drug eruption | 41.88 | 11.22 | 131 | 94480 | 43804 | 79605973 |
Acute hepatic failure | 41.81 | 11.22 | 103 | 94508 | 30010 | 79619767 |
Platelet count increased | 41.57 | 11.22 | 86 | 94525 | 22320 | 79627457 |
Nosocomial infection | 41.25 | 11.22 | 31 | 94580 | 2801 | 79646976 |
Gastrooesophageal reflux disease | 40.88 | 11.22 | 38 | 94573 | 104208 | 79545569 |
Asthenia | 40.85 | 11.22 | 399 | 94212 | 511290 | 79138487 |
Disseminated cryptococcosis | 40.68 | 11.22 | 26 | 94585 | 1808 | 79647969 |
Blood glucose increased | 40.45 | 11.22 | 46 | 94565 | 114929 | 79534848 |
Road traffic accident | 40.27 | 11.22 | 3 | 94608 | 43661 | 79606116 |
SJS-TEN overlap | 39.84 | 11.22 | 19 | 94592 | 740 | 79649037 |
Gastrointestinal disorder | 39.71 | 11.22 | 52 | 94559 | 122153 | 79527624 |
Hepatitis fulminant | 39.68 | 11.22 | 46 | 94565 | 7216 | 79642561 |
International normalised ratio increased | 39.56 | 11.22 | 202 | 94409 | 84519 | 79565258 |
Therapeutic product effect incomplete | 39.49 | 11.22 | 67 | 94544 | 141578 | 79508199 |
Suicidal ideation | 38.90 | 11.22 | 21 | 94590 | 76319 | 79573458 |
Vision blurred | 38.76 | 11.22 | 41 | 94570 | 105857 | 79543920 |
Hypofibrinogenaemia | 38.60 | 11.22 | 26 | 94585 | 1976 | 79647801 |
Liver function test increased | 38.29 | 11.22 | 119 | 94492 | 39654 | 79610123 |
Influenza B virus test positive | 37.95 | 11.22 | 15 | 94596 | 367 | 79649410 |
Procalcitonin increased | 37.46 | 11.22 | 30 | 94581 | 2976 | 79646801 |
Cardiac failure congestive | 37.32 | 11.22 | 70 | 94541 | 142332 | 79507445 |
Diarrhoea | 37.15 | 11.22 | 780 | 93831 | 879709 | 78770068 |
Bacterial pericarditis | 37.05 | 11.22 | 10 | 94601 | 67 | 79649710 |
Hepatomegaly | 36.86 | 11.22 | 74 | 94537 | 18800 | 79630977 |
CSF oligoclonal band present | 36.53 | 11.22 | 15 | 94596 | 406 | 79649371 |
Unresponsive to stimuli | 36.52 | 11.22 | 147 | 94464 | 55641 | 79594136 |
No adverse event | 36.47 | 11.22 | 112 | 94499 | 37080 | 79612697 |
Alveolitis | 36.42 | 11.22 | 34 | 94577 | 4146 | 79645631 |
Adverse event | 36.31 | 11.22 | 13 | 94598 | 60201 | 79589576 |
Renal papillary necrosis | 36.23 | 11.22 | 15 | 94596 | 415 | 79649362 |
Systemic candida | 35.84 | 11.22 | 42 | 94569 | 6664 | 79643113 |
Tachycardia | 35.79 | 11.22 | 345 | 94266 | 177423 | 79472354 |
Hepatitis toxic | 35.77 | 11.22 | 37 | 94574 | 5110 | 79644667 |
Bronchopleural fistula | 35.65 | 11.22 | 17 | 94594 | 662 | 79649115 |
Morganella infection | 35.44 | 11.22 | 20 | 94591 | 1107 | 79648670 |
Erythema multiforme | 35.43 | 11.22 | 70 | 94541 | 17581 | 79632196 |
Splenomegaly | 35.43 | 11.22 | 77 | 94534 | 20677 | 79629100 |
Loss of personal independence in daily activities | 35.05 | 11.22 | 42 | 94569 | 102538 | 79547239 |
Chest pain | 34.56 | 11.22 | 195 | 94416 | 282109 | 79367668 |
Alcohol intolerance | 34.49 | 11.22 | 15 | 94596 | 470 | 79649307 |
Nasal polyps | 34.44 | 11.22 | 43 | 94568 | 7284 | 79642493 |
Injection site swelling | 34.39 | 11.22 | 7 | 94604 | 47125 | 79602652 |
Cerebrovascular accident | 34.32 | 11.22 | 84 | 94527 | 155208 | 79494569 |
Impaired healing | 34.31 | 11.22 | 32 | 94579 | 87623 | 79562154 |
Dry skin | 34.22 | 11.22 | 19 | 94592 | 67976 | 79581801 |
Orthostatic hypotension | 34.08 | 11.22 | 12 | 94599 | 56152 | 79593625 |
Wrong technique in product usage process | 33.90 | 11.22 | 23 | 94588 | 73852 | 79575925 |
Coagulation factor decreased | 33.78 | 11.22 | 12 | 94599 | 216 | 79649561 |
Partial seizures | 33.43 | 11.22 | 47 | 94564 | 8931 | 79640846 |
Erythema nodosum | 33.01 | 11.22 | 36 | 94575 | 5281 | 79644496 |
Crystalluria | 32.98 | 11.22 | 18 | 94593 | 933 | 79648844 |
Cryptococcal meningoencephalitis | 32.24 | 11.22 | 12 | 94599 | 248 | 79649529 |
Rash erythematous | 32.22 | 11.22 | 145 | 94466 | 57624 | 79592153 |
Ureteral disorder | 32.09 | 11.22 | 15 | 94596 | 558 | 79649219 |
Influenza like illness | 32.01 | 11.22 | 23 | 94588 | 71684 | 79578093 |
Renal tubular necrosis | 32.00 | 11.22 | 83 | 94528 | 24956 | 79624821 |
Blood uric acid increased | 31.81 | 11.22 | 57 | 94554 | 13303 | 79636474 |
Multiple sclerosis relapse | 31.77 | 11.22 | 8 | 94603 | 46525 | 79603252 |
Fluid retention | 31.68 | 11.22 | 22 | 94589 | 69787 | 79579990 |
Neutrophilia | 31.67 | 11.22 | 43 | 94568 | 7908 | 79641869 |
Hip arthroplasty | 31.48 | 11.22 | 3 | 94608 | 35753 | 79614024 |
Drug effective for unapproved indication | 31.10 | 11.22 | 37 | 94574 | 5964 | 79643813 |
Product use issue | 30.79 | 11.22 | 136 | 94475 | 209686 | 79440091 |
Decreased appetite | 30.78 | 11.22 | 259 | 94352 | 342159 | 79307618 |
Coronary artery disease | 30.56 | 11.22 | 20 | 94591 | 65454 | 79584323 |
Gamma-glutamyltransferase increased | 30.31 | 11.22 | 137 | 94474 | 54543 | 79595234 |
Cholecystitis acute | 30.27 | 11.22 | 56 | 94555 | 13395 | 79636382 |
Oropharyngeal pain | 30.23 | 11.22 | 52 | 94559 | 109301 | 79540476 |
Intracranial pressure increased | 30.15 | 11.22 | 43 | 94568 | 8279 | 79641498 |
Muscle injury | 30.11 | 11.22 | 10 | 94601 | 48551 | 79601226 |
Rhinitis allergic | 30.05 | 11.22 | 53 | 94558 | 12216 | 79637561 |
Autoimmune haemolytic anaemia | 29.92 | 11.22 | 43 | 94568 | 8337 | 79641440 |
Malignant mesenteric neoplasm | 29.72 | 11.22 | 8 | 94603 | 53 | 79649724 |
Purpura | 29.48 | 11.22 | 69 | 94542 | 19458 | 79630319 |
Hyperphosphataemia | 29.30 | 11.22 | 37 | 94574 | 6339 | 79643438 |
Blood pressure systolic increased | 29.24 | 11.22 | 22 | 94589 | 66964 | 79582813 |
CSF measles antibody positive | 29.21 | 11.22 | 8 | 94603 | 57 | 79649720 |
Visual impairment | 29.12 | 11.22 | 40 | 94571 | 92091 | 79557686 |
Vasculitis | 28.85 | 11.22 | 80 | 94531 | 25022 | 79624755 |
Herpes zoster | 28.84 | 11.22 | 41 | 94570 | 93042 | 79556735 |
Rubella antibody positive | 28.74 | 11.22 | 8 | 94603 | 61 | 79649716 |
Sciatica | 28.70 | 11.22 | 3 | 94608 | 33219 | 79616558 |
Anti factor V antibody | 28.69 | 11.22 | 5 | 94606 | 0 | 79649777 |
Hypercreatininaemia | 28.63 | 11.22 | 17 | 94594 | 1036 | 79648741 |
Weber tuning fork test abnormal | 28.54 | 11.22 | 9 | 94602 | 110 | 79649667 |
Gastric disorder | 28.50 | 11.22 | 5 | 94606 | 37428 | 79612349 |
Pyuria | 28.31 | 11.22 | 23 | 94588 | 2329 | 79647448 |
Cholestatic liver injury | 28.18 | 11.22 | 32 | 94579 | 4909 | 79644868 |
Neoplasm progression | 28.17 | 11.22 | 13 | 94598 | 51669 | 79598108 |
Organic brain syndrome | 28.13 | 11.22 | 13 | 94598 | 471 | 79649306 |
Angioedema | 27.97 | 11.22 | 170 | 94441 | 75865 | 79573912 |
Portal fibrosis | 27.96 | 11.22 | 14 | 94597 | 607 | 79649170 |
Transient ischaemic attack | 27.58 | 11.22 | 14 | 94597 | 52681 | 79597096 |
Procalcitonin abnormal | 27.53 | 11.22 | 12 | 94599 | 378 | 79649399 |
Sleep apnoea syndrome | 27.50 | 11.22 | 5 | 94606 | 36473 | 79613304 |
Nephropathy toxic | 27.46 | 11.22 | 69 | 94542 | 20350 | 79629427 |
Systemic inflammatory response syndrome | 27.41 | 11.22 | 49 | 94562 | 11416 | 79638361 |
Propofol infusion syndrome | 27.32 | 11.22 | 21 | 94590 | 1962 | 79647815 |
Liver injury | 27.14 | 11.22 | 136 | 94475 | 56478 | 79593299 |
Coagulopathy | 26.94 | 11.22 | 99 | 94512 | 35907 | 79613870 |
Janeway lesion | 26.93 | 11.22 | 6 | 94605 | 15 | 79649762 |
Face oedema | 26.91 | 11.22 | 84 | 94527 | 28052 | 79621725 |
Device related sepsis | 26.78 | 11.22 | 35 | 94576 | 6205 | 79643572 |
Neck pain | 26.71 | 11.22 | 30 | 94581 | 75387 | 79574390 |
Analgesic therapy | 26.68 | 11.22 | 16 | 94595 | 993 | 79648784 |
Empyema | 26.63 | 11.22 | 29 | 94582 | 4247 | 79645530 |
Flank pain | 26.63 | 11.22 | 67 | 94544 | 19777 | 79630000 |
Vascular purpura | 26.61 | 11.22 | 25 | 94586 | 3073 | 79646704 |
Maternal exposure during pregnancy | 26.50 | 11.22 | 263 | 94348 | 136275 | 79513502 |
Nervousness | 26.48 | 11.22 | 4 | 94607 | 33411 | 79616366 |
Hyperthermia | 26.43 | 11.22 | 63 | 94548 | 17974 | 79631803 |
Cerebral cyst | 26.43 | 11.22 | 12 | 94599 | 417 | 79649360 |
Peritoneal dialysis | 26.41 | 11.22 | 15 | 94596 | 841 | 79648936 |
Mitochondrial DNA mutation | 26.33 | 11.22 | 12 | 94599 | 421 | 79649356 |
Sphincter of Oddi dysfunction | 26.33 | 11.22 | 12 | 94599 | 421 | 79649356 |
Hepatitis infectious mononucleosis | 26.03 | 11.22 | 9 | 94602 | 149 | 79649628 |
Hip fracture | 26.01 | 11.22 | 3 | 94608 | 30758 | 79619019 |
Hepatosplenomegaly | 25.98 | 11.22 | 34 | 94577 | 6035 | 79643742 |
Injection site pruritus | 25.71 | 11.22 | 9 | 94602 | 42274 | 79607503 |
Pneumonia mycoplasmal | 25.67 | 11.22 | 18 | 94593 | 1460 | 79648317 |
Stress | 25.58 | 11.22 | 172 | 94439 | 79440 | 79570337 |
Muscle abscess | 25.57 | 11.22 | 16 | 94595 | 1072 | 79648705 |
Blood creatinine increased | 25.56 | 11.22 | 289 | 94322 | 154768 | 79495009 |
Multiple-drug resistance | 25.50 | 11.22 | 41 | 94570 | 8767 | 79641010 |
Pyelonephritis | 25.46 | 11.22 | 67 | 94544 | 20321 | 79629456 |
Encephalitis brain stem | 25.44 | 11.22 | 10 | 94601 | 241 | 79649536 |
COVID-19 treatment | 25.39 | 11.22 | 12 | 94599 | 458 | 79649319 |
Meningitis bacterial | 25.31 | 11.22 | 23 | 94588 | 2709 | 79647068 |
Leukaemoid reaction | 25.28 | 11.22 | 11 | 94600 | 345 | 79649432 |
Neuropathy peripheral | 24.95 | 11.22 | 85 | 94526 | 141220 | 79508557 |
Corynebacterium infection | 24.90 | 11.22 | 17 | 94594 | 1321 | 79648456 |
Gait inability | 24.89 | 11.22 | 20 | 94591 | 58897 | 79590880 |
Normal newborn | 24.83 | 11.22 | 36 | 94575 | 7036 | 79642741 |
Serum sickness-like reaction | 24.78 | 11.22 | 13 | 94598 | 622 | 79649155 |
Amnesia | 24.70 | 11.22 | 23 | 94588 | 63034 | 79586743 |
Dysgeusia | 24.67 | 11.22 | 19 | 94592 | 57158 | 79592619 |
Vascular device infection | 24.67 | 11.22 | 44 | 94567 | 10232 | 79639545 |
Localised infection | 24.63 | 11.22 | 7 | 94604 | 37568 | 79612209 |
Cheilitis | 24.56 | 11.22 | 31 | 94580 | 5310 | 79644467 |
Blood alkaline phosphatase increased | 24.47 | 11.22 | 144 | 94467 | 63520 | 79586257 |
Hypokalaemia | 24.44 | 11.22 | 270 | 94341 | 143770 | 79506007 |
Basal cell carcinoma | 24.43 | 11.22 | 7 | 94604 | 37368 | 79612409 |
Joint stiffness | 24.30 | 11.22 | 9 | 94602 | 40821 | 79608956 |
Joint injury | 24.27 | 11.22 | 4 | 94607 | 31331 | 79618446 |
Type I hypersensitivity | 24.26 | 11.22 | 28 | 94583 | 4370 | 79645407 |
Suicide attempt | 24.26 | 11.22 | 38 | 94573 | 82894 | 79566883 |
Drug therapy | 24.12 | 11.22 | 16 | 94595 | 1185 | 79648592 |
Sedation | 24.02 | 11.22 | 16 | 94595 | 51879 | 79597898 |
Haemostasis | 24.00 | 11.22 | 11 | 94600 | 391 | 79649386 |
Mycotic endophthalmitis | 23.87 | 11.22 | 9 | 94602 | 193 | 79649584 |
Chorioretinitis | 23.70 | 11.22 | 15 | 94596 | 1025 | 79648752 |
Jejunal ulcer perforation | 23.68 | 11.22 | 8 | 94603 | 123 | 79649654 |
Breath sounds abnormal | 23.61 | 11.22 | 56 | 94555 | 15928 | 79633849 |
Pneumonia bacterial | 23.60 | 11.22 | 63 | 94548 | 19268 | 79630509 |
Granulomatous dermatitis | 23.51 | 11.22 | 11 | 94600 | 410 | 79649367 |
Ureteric obstruction | 23.49 | 11.22 | 22 | 94589 | 2694 | 79647083 |
Lip oedema | 23.42 | 11.22 | 33 | 94578 | 6283 | 79643494 |
Brain herniation | 23.35 | 11.22 | 36 | 94575 | 7427 | 79642350 |
Hyperbilirubinaemia | 23.27 | 11.22 | 73 | 94538 | 24445 | 79625332 |
Intentional self-injury | 23.27 | 11.22 | 5 | 94606 | 32414 | 79617363 |
Staphylococcal infection | 23.15 | 11.22 | 133 | 94478 | 58162 | 79591615 |
Pruritus | 22.99 | 11.22 | 622 | 93989 | 394026 | 79255751 |
Myopathy toxic | 22.96 | 11.22 | 15 | 94596 | 1083 | 79648694 |
Hyperferritinaemia | 22.93 | 11.22 | 13 | 94598 | 726 | 79649051 |
Bursitis | 22.90 | 11.22 | 7 | 94604 | 35837 | 79613940 |
Influenza | 22.86 | 11.22 | 78 | 94533 | 129528 | 79520249 |
Cholangitis acute | 22.83 | 11.22 | 17 | 94594 | 1515 | 79648262 |
Lymphadenopathy | 22.82 | 11.22 | 124 | 94487 | 53123 | 79596654 |
Heart rate decreased | 22.76 | 11.22 | 30 | 94581 | 70286 | 79579491 |
Dyspnoea exertional | 22.64 | 11.22 | 43 | 94568 | 87030 | 79562747 |
Drug dependence | 22.61 | 11.22 | 10 | 94601 | 40759 | 79609018 |
Otitis media acute | 22.57 | 11.22 | 16 | 94595 | 1321 | 79648456 |
Infection | 22.54 | 11.22 | 181 | 94430 | 241531 | 79408246 |
Blood brain barrier defect | 22.52 | 11.22 | 8 | 94603 | 144 | 79649633 |
Pancreatitis acute | 22.27 | 11.22 | 117 | 94494 | 49487 | 79600290 |
Bacterial parotitis | 22.13 | 11.22 | 6 | 94605 | 41 | 79649736 |
Interleukin-2 receptor increased | 22.01 | 11.22 | 9 | 94602 | 241 | 79649536 |
Pelvic inflammatory disease | 21.99 | 11.22 | 16 | 94595 | 1376 | 79648401 |
Factor V deficiency | 21.94 | 11.22 | 7 | 94604 | 89 | 79649688 |
Rash | 21.68 | 11.22 | 865 | 93746 | 577493 | 79072284 |
Pain in jaw | 21.67 | 11.22 | 14 | 94597 | 46137 | 79603640 |
Surgery | 21.67 | 11.22 | 6 | 94605 | 32760 | 79617017 |
Omental necrosis | 21.64 | 11.22 | 6 | 94605 | 45 | 79649732 |
Mixed liver injury | 21.57 | 11.22 | 35 | 94576 | 7543 | 79642234 |
Acquired haemophilia | 21.56 | 11.22 | 18 | 94593 | 1893 | 79647884 |
Paraesthesia | 21.45 | 11.22 | 122 | 94489 | 176201 | 79473576 |
Sleep disorder therapy | 21.44 | 11.22 | 14 | 94597 | 1010 | 79648767 |
Calculus urinary | 21.41 | 11.22 | 20 | 94591 | 2440 | 79647337 |
Hyperpyrexia | 21.37 | 11.22 | 31 | 94580 | 6061 | 79643716 |
Muscular weakness | 21.33 | 11.22 | 108 | 94503 | 160621 | 79489156 |
Tooth disorder | 21.11 | 11.22 | 3 | 94608 | 26230 | 79623547 |
Abdominal distension | 21.09 | 11.22 | 226 | 94385 | 119424 | 79530353 |
Eastern Cooperative Oncology Group performance status | 21.09 | 11.22 | 6 | 94605 | 50 | 79649727 |
Bronchospasm | 20.88 | 11.22 | 71 | 94540 | 24788 | 79624989 |
Fibrin D dimer increased | 20.70 | 11.22 | 37 | 94574 | 8617 | 79641160 |
Antinuclear antibody negative | 20.67 | 11.22 | 5 | 94606 | 20 | 79649757 |
Laryngeal stenosis | 20.66 | 11.22 | 14 | 94597 | 1074 | 79648703 |
Encephalitis autoimmune | 20.64 | 11.22 | 19 | 94592 | 2275 | 79647502 |
Cardiac ventricular thrombosis | 20.63 | 11.22 | 17 | 94594 | 1756 | 79648021 |
Generalised bullous fixed drug eruption | 20.58 | 11.22 | 8 | 94603 | 187 | 79649590 |
Cryptococcosis | 20.56 | 11.22 | 23 | 94588 | 3470 | 79646307 |
Vitamin K deficiency | 20.44 | 11.22 | 12 | 94599 | 716 | 79649061 |
Gastroenteritis clostridial | 20.20 | 11.22 | 13 | 94598 | 915 | 79648862 |
Strongyloidiasis | 20.15 | 11.22 | 24 | 94587 | 3874 | 79645903 |
Pulmonary physical examination abnormal | 20.10 | 11.22 | 5 | 94606 | 23 | 79649754 |
Liver transplant failure | 20.02 | 11.22 | 7 | 94604 | 120 | 79649657 |
Hyperamylasaemia | 20.00 | 11.22 | 14 | 94597 | 1133 | 79648644 |
Ear pain | 19.98 | 11.22 | 7 | 94604 | 32862 | 79616915 |
Hypoalbuminaemia | 19.83 | 11.22 | 63 | 94548 | 21234 | 79628543 |
Stress cardiomyopathy | 19.71 | 11.22 | 42 | 94569 | 11124 | 79638653 |
Blood gases abnormal | 19.64 | 11.22 | 14 | 94597 | 1166 | 79648611 |
Upper-airway cough syndrome | 19.52 | 11.22 | 43 | 94568 | 11650 | 79638127 |
Cerebellar syndrome | 19.39 | 11.22 | 28 | 94583 | 5452 | 79644325 |
CSF protein increased | 19.01 | 11.22 | 14 | 94597 | 1226 | 79648551 |
Encephalomalacia | 19.00 | 11.22 | 14 | 94597 | 1227 | 79648550 |
Infective chondritis | 19.00 | 11.22 | 5 | 94606 | 30 | 79649747 |
Hyperlactacidaemia | 18.94 | 11.22 | 28 | 94583 | 5567 | 79644210 |
Pneumothorax | 18.83 | 11.22 | 75 | 94536 | 28248 | 79621529 |
Lymphopenia | 18.80 | 11.22 | 79 | 94532 | 30478 | 79619299 |
Dehydration | 18.73 | 11.22 | 196 | 94415 | 247991 | 79401786 |
Urinary tract infection fungal | 18.70 | 11.22 | 13 | 94598 | 1040 | 79648737 |
Flatulence | 18.68 | 11.22 | 14 | 94597 | 42710 | 79607067 |
Normocytic anaemia | 18.68 | 11.22 | 24 | 94587 | 4183 | 79645594 |
Injury | 18.67 | 11.22 | 40 | 94571 | 77456 | 79572321 |
Hypernatraemia | 18.57 | 11.22 | 48 | 94563 | 14403 | 79635374 |
Vanishing bile duct syndrome | 18.53 | 11.22 | 16 | 94595 | 1762 | 79648015 |
Endocarditis bacterial | 18.50 | 11.22 | 15 | 94596 | 1514 | 79648263 |
Iris transillumination defect | 18.49 | 11.22 | 7 | 94604 | 152 | 79649625 |
Antibiotic level below therapeutic | 18.48 | 11.22 | 6 | 94605 | 81 | 79649696 |
Petechiae | 18.39 | 11.22 | 60 | 94551 | 20505 | 79629272 |
Macule | 18.32 | 11.22 | 20 | 94591 | 2937 | 79646840 |
Coombs negative haemolytic anaemia | 18.26 | 11.22 | 9 | 94602 | 377 | 79649400 |
Antibiotic associated colitis | 18.25 | 11.22 | 4 | 94607 | 9 | 79649768 |
Hypertriglyceridaemia | 18.13 | 11.22 | 44 | 94567 | 12696 | 79637081 |
Sneezing | 18.12 | 11.22 | 58 | 94553 | 19625 | 79630152 |
Hypovolaemic shock | 18.12 | 11.22 | 43 | 94568 | 12233 | 79637544 |
Type IIa hyperlipidaemia | 18.09 | 11.22 | 8 | 94603 | 261 | 79649516 |
Cell death | 18.09 | 11.22 | 25 | 94586 | 4674 | 79645103 |
Head injury | 18.01 | 11.22 | 11 | 94600 | 37358 | 79612419 |
Bone marrow failure | 17.99 | 11.22 | 113 | 94498 | 50994 | 79598783 |
Postpartum sepsis | 17.95 | 11.22 | 4 | 94607 | 10 | 79649767 |
Pneumonia pneumococcal | 17.88 | 11.22 | 23 | 94588 | 4014 | 79645763 |
Syncope | 17.84 | 11.22 | 132 | 94479 | 179317 | 79470460 |
Malabsorption from administration site | 17.83 | 11.22 | 7 | 94604 | 168 | 79649609 |
Prothrombin time ratio decreased | 17.80 | 11.22 | 12 | 94599 | 913 | 79648864 |
Hypocoagulable state | 17.74 | 11.22 | 17 | 94594 | 2142 | 79647635 |
Relapsing fever | 17.65 | 11.22 | 9 | 94602 | 406 | 79649371 |
Overdose | 17.60 | 11.22 | 137 | 94474 | 184069 | 79465708 |
Depressed mood | 17.48 | 11.22 | 19 | 94592 | 48461 | 79601316 |
Metastases to stomach | 17.46 | 11.22 | 8 | 94603 | 284 | 79649493 |
Skin test positive | 17.43 | 11.22 | 13 | 94598 | 1161 | 79648616 |
Blood pressure diastolic decreased | 17.42 | 11.22 | 7 | 94604 | 30209 | 79619568 |
Pneumococcal sepsis | 17.41 | 11.22 | 15 | 94596 | 1647 | 79648130 |
Pyelonephritis acute | 17.39 | 11.22 | 28 | 94583 | 5995 | 79643782 |
Osteomyelitis fungal | 17.31 | 11.22 | 8 | 94603 | 290 | 79649487 |
Bacteraemia | 17.27 | 11.22 | 81 | 94530 | 32743 | 79617034 |
Renal impairment | 17.24 | 11.22 | 273 | 94338 | 157510 | 79492267 |
Megacolon | 17.22 | 11.22 | 21 | 94590 | 3474 | 79646303 |
Red blood cell agglutination | 17.21 | 11.22 | 3 | 94608 | 0 | 79649777 |
Joint range of motion decreased | 17.18 | 11.22 | 9 | 94602 | 33273 | 79616504 |
Veillonella infection | 17.13 | 11.22 | 5 | 94606 | 46 | 79649731 |
Prescribed overdose | 17.11 | 11.22 | 12 | 94599 | 37871 | 79611906 |
Sinus disorder | 17.10 | 11.22 | 3 | 94608 | 22461 | 79627316 |
Hypersensitivity vasculitis | 17.02 | 11.22 | 30 | 94581 | 6913 | 79642864 |
Pneumonia necrotising | 16.92 | 11.22 | 13 | 94598 | 1214 | 79648563 |
Accidental exposure to product | 16.88 | 11.22 | 8 | 94603 | 31314 | 79618463 |
Injection site haemorrhage | 16.83 | 11.22 | 6 | 94605 | 27864 | 79621913 |
Arterial angioplasty | 16.76 | 11.22 | 5 | 94606 | 50 | 79649727 |
Dysstasia | 16.71 | 11.22 | 6 | 94605 | 27740 | 79622037 |
Osteonecrosis of jaw | 16.65 | 11.22 | 16 | 94595 | 43210 | 79606567 |
Cardiac disorder | 16.63 | 11.22 | 33 | 94578 | 65724 | 79584053 |
Pollakiuria | 16.61 | 11.22 | 12 | 94599 | 37305 | 79612472 |
Tracheobronchitis | 16.60 | 11.22 | 16 | 94595 | 2030 | 79647747 |
Foot fracture | 16.59 | 11.22 | 3 | 94608 | 21978 | 79627799 |
Carotid artery insufficiency | 16.53 | 11.22 | 4 | 94607 | 16 | 79649761 |
Bacteriuria | 16.51 | 11.22 | 13 | 94598 | 1258 | 79648519 |
Incorrect dose administered | 16.49 | 11.22 | 42 | 94569 | 76588 | 79573189 |
Haemorrhoids | 16.39 | 11.22 | 7 | 94604 | 29121 | 79620656 |
Dry eye | 16.28 | 11.22 | 12 | 94599 | 36919 | 79612858 |
Foetal death | 16.26 | 11.22 | 32 | 94579 | 8012 | 79641765 |
Henoch-Schonlein purpura | 16.22 | 11.22 | 18 | 94593 | 2692 | 79647085 |
Guillain-Barre syndrome | 16.15 | 11.22 | 34 | 94577 | 8931 | 79640846 |
Septic pulmonary embolism | 16.12 | 11.22 | 6 | 94605 | 124 | 79649653 |
Obesity | 16.03 | 11.22 | 11 | 94600 | 35114 | 79614663 |
Eosinophilic pneumonia acute | 15.95 | 11.22 | 12 | 94599 | 1086 | 79648691 |
Abdominal wall haematoma | 15.95 | 11.22 | 24 | 94587 | 4849 | 79644928 |
Delirium | 15.92 | 11.22 | 162 | 94449 | 84465 | 79565312 |
Abdominal compartment syndrome | 15.90 | 11.22 | 14 | 94597 | 1583 | 79648194 |
Bone pain | 15.87 | 11.22 | 26 | 94585 | 55716 | 79594061 |
Lower limb fracture | 15.83 | 11.22 | 4 | 94607 | 23211 | 79626566 |
Meningitis aseptic | 15.78 | 11.22 | 29 | 94582 | 6899 | 79642878 |
Eosinophilic pneumonia | 15.76 | 11.22 | 25 | 94586 | 5285 | 79644492 |
Shock haemorrhagic | 15.72 | 11.22 | 56 | 94555 | 20004 | 79629773 |
Blood cholesterol increased | 15.72 | 11.22 | 49 | 94562 | 83671 | 79566106 |
Procedural pain | 15.70 | 11.22 | 4 | 94607 | 23080 | 79626697 |
Therapeutic response decreased | 15.69 | 11.22 | 35 | 94576 | 66818 | 79582959 |
Device related bacteraemia | 15.69 | 11.22 | 10 | 94601 | 692 | 79649085 |
Palmar-plantar erythrodysaesthesia syndrome | 15.63 | 11.22 | 10 | 94601 | 33124 | 79616653 |
Pulmonary necrosis | 15.58 | 11.22 | 9 | 94602 | 521 | 79649256 |
Neuroborreliosis | 15.56 | 11.22 | 6 | 94605 | 137 | 79649640 |
Meningism | 15.53 | 11.22 | 10 | 94601 | 704 | 79649073 |
Hepatic failure | 15.52 | 11.22 | 125 | 94486 | 61087 | 79588690 |
Red blood cell sedimentation rate increased | 15.49 | 11.22 | 19 | 94592 | 45923 | 79603854 |
Allergy test positive | 15.36 | 11.22 | 10 | 94601 | 718 | 79649059 |
Central nervous system vasculitis | 15.35 | 11.22 | 13 | 94598 | 1395 | 79648382 |
Antimicrobial susceptibility test resistant | 15.30 | 11.22 | 8 | 94603 | 380 | 79649397 |
Heart rate irregular | 15.23 | 11.22 | 10 | 94601 | 32669 | 79617108 |
Limb injury | 15.22 | 11.22 | 8 | 94603 | 29520 | 79620257 |
Metastases to bone | 15.20 | 11.22 | 5 | 94606 | 24422 | 79625355 |
Endotracheal intubation | 15.18 | 11.22 | 23 | 94588 | 4674 | 79645103 |
Ocular icterus | 15.11 | 11.22 | 25 | 94586 | 5475 | 79644302 |
Feeling hot | 15.09 | 11.22 | 30 | 94581 | 59704 | 79590073 |
Lung consolidation | 15.05 | 11.22 | 33 | 94578 | 8914 | 79640863 |
Laryngeal mass | 15.04 | 11.22 | 5 | 94606 | 73 | 79649704 |
Malignant neoplasm progression | 15.01 | 11.22 | 97 | 94514 | 135893 | 79513884 |
Thunderclap headache | 14.98 | 11.22 | 8 | 94603 | 397 | 79649380 |
Multiple sclerosis | 14.89 | 11.22 | 4 | 94607 | 22278 | 79627499 |
Drug hypersensitivity | 14.88 | 11.22 | 462 | 94149 | 298454 | 79351323 |
Sleep disorder | 14.81 | 11.22 | 52 | 94559 | 85625 | 79564152 |
Septic embolus | 14.72 | 11.22 | 15 | 94596 | 2036 | 79647741 |
Red blood cell schistocytes present | 14.70 | 11.22 | 9 | 94602 | 580 | 79649197 |
Blood fibrinogen increased | 14.66 | 11.22 | 14 | 94597 | 1756 | 79648021 |
Gene mutation | 14.65 | 11.22 | 17 | 94594 | 2669 | 79647108 |
Diabetes insipidus | 14.65 | 11.22 | 24 | 94587 | 5213 | 79644564 |
Meningitis | 14.62 | 11.22 | 34 | 94577 | 9548 | 79640229 |
Pneumonia staphylococcal | 14.54 | 11.22 | 23 | 94588 | 4851 | 79644926 |
Haemodialysis | 14.48 | 11.22 | 51 | 94560 | 18117 | 79631660 |
Grip strength decreased | 14.47 | 11.22 | 4 | 94607 | 21865 | 79627912 |
Oral pain | 14.45 | 11.22 | 10 | 94601 | 31788 | 79617989 |
Muscle tension dysphonia | 14.42 | 11.22 | 6 | 94605 | 168 | 79649609 |
Hypothyroidism | 14.40 | 11.22 | 25 | 94586 | 52367 | 79597410 |
Eye pain | 14.37 | 11.22 | 14 | 94597 | 37564 | 79612213 |
Hot flush | 14.35 | 11.22 | 27 | 94584 | 54850 | 79594927 |
Amniotic cavity infection | 14.20 | 11.22 | 10 | 94601 | 817 | 79648960 |
Epistaxis | 14.19 | 11.22 | 76 | 94535 | 111439 | 79538338 |
Fungaemia | 14.16 | 11.22 | 22 | 94589 | 4569 | 79645208 |
Localised oedema | 14.14 | 11.22 | 30 | 94581 | 7922 | 79641855 |
Nephritis | 14.14 | 11.22 | 21 | 94590 | 4193 | 79645584 |
Rhinocerebral mucormycosis | 14.13 | 11.22 | 11 | 94600 | 1047 | 79648730 |
Vitamin A deficiency | 14.13 | 11.22 | 5 | 94606 | 89 | 79649688 |
Psychotic disorder | 14.09 | 11.22 | 17 | 94594 | 41385 | 79608392 |
Embolia cutis medicamentosa | 14.06 | 11.22 | 9 | 94602 | 627 | 79649150 |
Dysmetria | 14.01 | 11.22 | 11 | 94600 | 1060 | 79648717 |
Lymphocyte transformation test positive | 13.99 | 11.22 | 4 | 94607 | 34 | 79649743 |
Unevaluable event | 13.97 | 11.22 | 28 | 94583 | 55557 | 79594220 |
Rash pustular | 13.95 | 11.22 | 37 | 94574 | 11274 | 79638503 |
Post treatment Lyme disease syndrome | 13.93 | 11.22 | 3 | 94608 | 6 | 79649771 |
Illness | 13.90 | 11.22 | 21 | 94590 | 46490 | 79603287 |
Pancreatitis necrotising | 13.87 | 11.22 | 20 | 94591 | 3888 | 79645889 |
ADAMTS13 activity decreased | 13.85 | 11.22 | 6 | 94605 | 186 | 79649591 |
Myalgia | 13.84 | 11.22 | 147 | 94464 | 185494 | 79464283 |
Prescribed underdose | 13.79 | 11.22 | 9 | 94602 | 29505 | 79620272 |
Cardiac valve abscess | 13.78 | 11.22 | 4 | 94607 | 36 | 79649741 |
Glycosylated haemoglobin increased | 13.76 | 11.22 | 3 | 94608 | 19257 | 79630520 |
Fungal peritonitis | 13.75 | 11.22 | 11 | 94600 | 1089 | 79648688 |
Necrosis | 13.74 | 11.22 | 33 | 94578 | 9460 | 79640317 |
Idiosyncratic drug reaction | 13.72 | 11.22 | 12 | 94599 | 1345 | 79648432 |
Haematuria traumatic | 13.71 | 11.22 | 6 | 94605 | 191 | 79649586 |
Transverse sinus thrombosis | 13.70 | 11.22 | 9 | 94602 | 656 | 79649121 |
Hypotension | 13.67 | 11.22 | 646 | 93965 | 439671 | 79210106 |
Pseudomonas infection | 13.61 | 11.22 | 55 | 94556 | 20848 | 79628929 |
Listeriosis | 13.56 | 11.22 | 15 | 94596 | 2235 | 79647542 |
Pseudophaeochromocytoma | 13.54 | 11.22 | 5 | 94606 | 101 | 79649676 |
Tubulointerstitial nephritis and uveitis syndrome | 13.48 | 11.22 | 7 | 94604 | 328 | 79649449 |
Agitation | 13.45 | 11.22 | 179 | 94432 | 99536 | 79550241 |
Confabulation | 13.44 | 11.22 | 8 | 94603 | 490 | 79649287 |
POEMS syndrome | 13.41 | 11.22 | 4 | 94607 | 40 | 79649737 |
Staphylococcus test positive | 13.37 | 11.22 | 26 | 94585 | 6455 | 79643322 |
Panic attack | 13.34 | 11.22 | 6 | 94605 | 24210 | 79625567 |
Tooth infection | 13.32 | 11.22 | 3 | 94608 | 18829 | 79630948 |
PO2 decreased | 13.31 | 11.22 | 17 | 94594 | 2946 | 79646831 |
Infective spondylitis | 13.20 | 11.22 | 8 | 94603 | 506 | 79649271 |
Prostate cancer | 13.19 | 11.22 | 12 | 94599 | 33256 | 79616521 |
Respiratory acidosis | 13.17 | 11.22 | 36 | 94575 | 11164 | 79638613 |
Intentional product misuse | 13.16 | 11.22 | 63 | 94548 | 95102 | 79554675 |
Clostridial infection | 13.12 | 11.22 | 24 | 94587 | 5690 | 79644087 |
Lung abscess | 13.10 | 11.22 | 20 | 94591 | 4092 | 79645685 |
Hemianopia | 13.06 | 11.22 | 13 | 94598 | 1715 | 79648062 |
Histoplasmosis disseminated | 13.01 | 11.22 | 15 | 94596 | 2338 | 79647439 |
Anoxia | 12.99 | 11.22 | 7 | 94604 | 354 | 79649423 |
Ischaemic limb pain | 12.98 | 11.22 | 4 | 94607 | 45 | 79649732 |
Osteoporosis | 12.97 | 11.22 | 28 | 94583 | 54084 | 79595693 |
Multisystem inflammatory syndrome in children | 12.90 | 11.22 | 4 | 94607 | 46 | 79649731 |
White blood cell count decreased | 12.89 | 11.22 | 152 | 94459 | 188136 | 79461641 |
Acidosis | 12.87 | 11.22 | 52 | 94559 | 19710 | 79630067 |
Blood lactate dehydrogenase increased | 12.80 | 11.22 | 85 | 94526 | 39085 | 79610692 |
Pneumonia streptococcal | 12.73 | 11.22 | 16 | 94595 | 2729 | 79647048 |
Bronchial obstruction | 12.62 | 11.22 | 16 | 94595 | 2752 | 79647025 |
Dry gangrene | 12.60 | 11.22 | 10 | 94601 | 979 | 79648798 |
Toxic shock syndrome | 12.53 | 11.22 | 11 | 94600 | 1238 | 79648539 |
Pleural effusion | 12.52 | 11.22 | 242 | 94369 | 145020 | 79504757 |
Hepatic necrosis | 12.50 | 11.22 | 31 | 94580 | 9069 | 79640708 |
Hyper IgE syndrome | 12.43 | 11.22 | 8 | 94603 | 563 | 79649214 |
Injection site rash | 12.42 | 11.22 | 3 | 94608 | 17951 | 79631826 |
Glaucoma | 12.37 | 11.22 | 4 | 94607 | 19757 | 79630020 |
Blood potassium decreased | 12.35 | 11.22 | 96 | 94515 | 46416 | 79603361 |
Haemoglobinuria | 12.29 | 11.22 | 9 | 94602 | 782 | 79648995 |
Haemoperitoneum | 12.28 | 11.22 | 20 | 94591 | 4323 | 79645454 |
Heparin-induced thrombocytopenia | 12.27 | 11.22 | 32 | 94579 | 9650 | 79640127 |
Haemorrhoids thrombosed | 12.27 | 11.22 | 6 | 94605 | 247 | 79649530 |
Body temperature decreased | 12.27 | 11.22 | 12 | 94599 | 32133 | 79617644 |
Tuberculosis of genitourinary system | 12.25 | 11.22 | 4 | 94607 | 55 | 79649722 |
Pulmonary function test | 12.21 | 11.22 | 3 | 94608 | 13 | 79649764 |
Abdominal pain | 12.18 | 11.22 | 572 | 94039 | 388997 | 79260780 |
Meningitis candida | 12.05 | 11.22 | 5 | 94606 | 139 | 79649638 |
Conjunctival hyperaemia | 12.04 | 11.22 | 20 | 94591 | 4393 | 79645384 |
Chondrocalcinosis | 12.03 | 11.22 | 10 | 94601 | 1046 | 79648731 |
Neoplasm malignant | 11.99 | 11.22 | 12 | 94599 | 31798 | 79617979 |
Femur fracture | 11.99 | 11.22 | 17 | 94594 | 38635 | 79611142 |
Arthritis reactive | 11.90 | 11.22 | 8 | 94603 | 606 | 79649171 |
Intravascular haemolysis | 11.90 | 11.22 | 9 | 94602 | 821 | 79648956 |
Expired product administered | 11.85 | 11.22 | 26 | 94585 | 7025 | 79642752 |
Anticonvulsant drug level below therapeutic | 11.82 | 11.22 | 10 | 94601 | 1071 | 79648706 |
Osteomyelitis | 11.78 | 11.22 | 73 | 94538 | 32792 | 79616985 |
Acne | 11.77 | 11.22 | 9 | 94602 | 27181 | 79622596 |
Hyperkalaemia | 11.77 | 11.22 | 196 | 94415 | 114202 | 79535575 |
Throat irritation | 11.75 | 11.22 | 19 | 94592 | 40927 | 79608850 |
Mechanical urticaria | 11.71 | 11.22 | 7 | 94604 | 432 | 79649345 |
Coagulation factor V level decreased | 11.70 | 11.22 | 8 | 94603 | 623 | 79649154 |
Urine potassium increased | 11.70 | 11.22 | 3 | 94608 | 16 | 79649761 |
Periostosis | 11.70 | 11.22 | 3 | 94608 | 16 | 79649761 |
Upper respiratory tract infection | 11.67 | 11.22 | 62 | 94549 | 91106 | 79558671 |
Gastrointestinal mucormycosis | 11.66 | 11.22 | 7 | 94604 | 435 | 79649342 |
Wound infection | 11.65 | 11.22 | 7 | 94604 | 23984 | 79625793 |
Haematochezia | 11.56 | 11.22 | 59 | 94552 | 87586 | 79562191 |
Neuralgic amyotrophy | 11.50 | 11.22 | 6 | 94605 | 284 | 79649493 |
Normochromic anaemia | 11.42 | 11.22 | 7 | 94604 | 452 | 79649325 |
Metastases to heart | 11.40 | 11.22 | 6 | 94605 | 289 | 79649488 |
Alpha 1 microglobulin increased | 11.36 | 11.22 | 4 | 94607 | 70 | 79649707 |
CD4 lymphocytes increased | 11.34 | 11.22 | 6 | 94605 | 292 | 79649485 |
Tenderness | 11.34 | 11.22 | 7 | 94604 | 23635 | 79626142 |
Tetany | 11.24 | 11.22 | 15 | 94596 | 2713 | 79647064 |
None
Source | Code | Description |
---|---|---|
ATC | J01DD04 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Third-generation cephalosporins |
ATC | J01DD54 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Third-generation cephalosporins |
ATC | J01DD63 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Third-generation cephalosporins |
FDA CS | M0003827 | Cephalosporins |
FDA EPC | N0000175488 | Cephalosporin Antibacterial |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
CHEBI has role | CHEBI:35625 | beta-lactamase inhibitors |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
CHEBI has role | CHEBI:88188 | allergenic drug |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Gonococcal meningitis | indication | 151004 | |
Streptococcal meningitis | indication | 4510004 | DOID:11574 |
Septicemia due to Escherichia coli | indication | 9323009 | |
Bacterial septicemia | indication | 10001005 | DOID:0040085 |
Staphylococcal meningitis | indication | 12166008 | |
Gonorrhea | indication | 15628003 | DOID:7551 |
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Acute gonococcal cervicitis | indication | 20943002 | DOID:10615 |
Staphylococcal pneumonia | indication | 22754005 | |
Streptococcal septicemia | indication | 29577008 | |
Acute gonococcal urethritis | indication | 29864006 | |
Pneumonia due to Streptococcus | indication | 34020007 | |
Gonorrhea of rectum | indication | 42746002 | |
Gonococcal infection of joint | indication | 44743006 | |
Bacterial arthritis | indication | 48245008 | |
Salmonella septicemia | indication | 49786009 | |
Lower respiratory tract infection | indication | 50417007 | |
Pneumococcal meningitis | indication | 51169003 | |
Pneumonia due to Escherichia coli | indication | 51530003 | |
Bacterial pneumonia | indication | 53084003 | DOID:874 |
Klebsiella cystitis | indication | 60867007 | |
Gonococcal endocarditis | indication | 61048000 | |
Acute gonococcal endometritis | indication | 65295003 | DOID:7527 |
Haemophilus influenzae pneumonia | indication | 70036007 | |
Infection due to Escherichia coli | indication | 71057007 | |
Bacterial infection due to Serratia | indication | 71120004 | |
Rhinoscleroma | indication | 72409005 | DOID:11336 |
Gonorrhea of pharynx | indication | 74372003 | |
Endometritis | indication | 78623009 | DOID:1002 |
Bacterial meningitis | indication | 95883001 | DOID:9470 |
Infection of bone | indication | 111253001 | |
Staphylococcal septicemia | indication | 111821004 | |
Female genital tract infection | indication | 125585007 | |
Infectious disease of abdomen | indication | 128070006 | |
Infection due to Enterobacteriaceae | indication | 128945009 | |
Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
Meningococcal meningitis | indication | 192644005 | |
Escherichia coli meningitis | indication | 192655005 | |
Proteus pneumonia | indication | 195888009 | |
Chancroid | indication | 266143009 | DOID:13778 |
Escherichia coli urinary tract infection | indication | 301011002 | |
Proteus urinary tract infection | indication | 301012009 | |
Streptococcus pyogenes infection | indication | 302809008 | |
Bacterial urinary infection | indication | 312124009 | |
Infective otitis media | indication | 312218008 | |
Infectious disorder of joint | indication | 363162000 | |
Meningitis due to Klebsiella mobilis | indication | 420585007 | |
Peptostreptococcus infection | indication | 135341000119101 | |
Klebsiella Pneumoniae Osteomyelitis | indication | ||
Inflammatory Disease of Female Pelvic Organs | indication | ||
Proteus Mirabilis Osteomyelitis | indication | ||
Peptostreptococcus Peritonitis | indication | ||
Enterobacter Pneumonia | indication | ||
Proteus Joint Infection | indication | ||
Haemophilus Septic Arthritis | indication | ||
Skin and Skin Structure Serratia Infection | indication | ||
E. Coli Peritonitis | indication | ||
Prevention of Perioperative Infection | indication | ||
Haemophilus Influenzae Type B Infections | indication | ||
Adult Gonococcal Conjunctivitis | indication | ||
E. Coli Septic Arthritis | indication | ||
Haemophilus Septicemia | indication | ||
Disseminated Gonococcal Infection | indication | ||
Klebsiella Pneumoniae Peritonitis | indication | ||
H. Influenzae Meningitis | indication | ||
Prevention of Meningococcal Meningitis | indication | ||
Gram-Negative Aerobic Bacillary Pneumonia | indication | ||
Skin and Skin Structure Proteus Infection | indication | ||
Haemophilus Osteomyelitis | indication | ||
Haemophilus Parainfluenzae Pneumonia | indication | ||
Enterobacter Osteomyelitis | indication | ||
Streptococcal Joint Infection | indication | ||
Pelvic Inflammatory Disease with Neisseria Gonorrhea | indication | ||
Klebsiella Joint Infection | indication | ||
EnterobacterJoint Infection | indication | ||
Skin and Skin Structure Morganella Morganii Infection | indication | ||
Streptococcus Osteomyelitis | indication | ||
E. Coli Joint Infection | indication | ||
E. Coli Osteomyelitis | indication | ||
Pyrexia of unknown origin | off-label use | 7520000 | |
Lyme disease | off-label use | 23502006 | DOID:11729 |
Lyme arthritis | off-label use | 33937009 | |
Pseudotuberculosis | off-label use | 36753006 | |
Lyme carditis | off-label use | 77863005 | |
Infection by Yersinia enterocolitica | off-label use | 80960004 | |
Ventilator-acquired pneumonia | off-label use | 429271009 | |
Lyme Disease of the Central Nervous System | off-label use | ||
Sexual Transmitted Disease Exposure from Sexual Assault | off-label use | ||
Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
Acute nephropathy | contraindication | 58574008 | |
Hemolytic anemia | contraindication | 61261009 | DOID:583 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Neonatal hyperbilirubinemia | contraindication | 281610001 | |
Pseudomembranous enterocolitis | contraindication | 397683000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.65 | acidic |
pKa2 | 4.17 | acidic |
pKa3 | 13.31 | acidic |
pKa4 | 3.29 | Basic |
pKa5 | 0.93 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
D-amino-acid oxidase | Enzyme | IC50 | 5 | CHEMBL | |||||
Alpha-synuclein | Transporter | Kd | 6.28 | CHEMBL | |||||
Peptidoglycan synthase FtsI | Enzyme | INHIBITOR | IC50 | 6.14 | WOMBAT-PK | CHEMBL | |||
Penicillin-binding protein 1A | Enzyme | INHIBITOR | IC50 | 6.51 | WOMBAT-PK | CHEMBL | |||
Penicillin-binding protein 1B | Enzyme | INHIBITOR | IC50 | 5.74 | WOMBAT-PK | CHEMBL | |||
Penicillin-binding protein 2 | Enzyme | INHIBITOR | IC50 | 6.21 | WOMBAT-PK | CHEMBL |
ID | Source |
---|---|
4019667 | VUID |
N0000147759 | NUI |
D00924 | KEGG_DRUG |
104376-79-6 | SECONDARY_CAS_RN |
203172 | RXNORM |
C0007561 | UMLSCUI |
CHEBI:29007 | CHEBI |
9F2 | PDB_CHEM_ID |
CHEMBL1200995 | ChEMBL_ID |
CHEMBL161 | ChEMBL_ID |
CHEMBL3183968 | ChEMBL_ID |
D002443 | MESH_DESCRIPTOR_UI |
DB01212 | DRUGBANK_ID |
5326 | IUPHAR_LIGAND_ID |
4923 | INN_ID |
75J73V1629 | UNII |
5479530 | PUBCHEM_CID |
1314 | MMSL |
4387 | MMSL |
69782 | MMSL |
d00052 | MMSL |
002734 | NDDF |
004849 | NDDF |
19841008 | SNOMEDCT_US |
33440000 | SNOMEDCT_US |
372670001 | SNOMEDCT_US |
4017814 | VANDF |
4019667 | VANDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9678 | INJECTION, POWDER, FOR SOLUTION | 10 g | INTRAVENOUS | ANDA | 26 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9678 | INJECTION, POWDER, FOR SOLUTION | 10 g | INTRAVENOUS | ANDA | 26 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9768 | INJECTION, POWDER, FOR SOLUTION | 10 g | INTRAVENOUS | ANDA | 23 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9856 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAMUSCULAR | ANDA | 24 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9856 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAMUSCULAR | ANDA | 24 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9856 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAMUSCULAR | ANDA | 24 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9857 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAMUSCULAR | ANDA | 24 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9857 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAMUSCULAR | ANDA | 24 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9857 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAMUSCULAR | ANDA | 24 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9858 | INJECTION, POWDER, FOR SOLUTION | 500 mg | INTRAMUSCULAR | ANDA | 24 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9858 | INJECTION, POWDER, FOR SOLUTION | 500 mg | INTRAMUSCULAR | ANDA | 24 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9858 | INJECTION, POWDER, FOR SOLUTION | 500 mg | INTRAMUSCULAR | ANDA | 24 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9859 | INJECTION, POWDER, FOR SOLUTION | 250 mg | INTRAMUSCULAR | ANDA | 24 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9859 | INJECTION, POWDER, FOR SOLUTION | 250 mg | INTRAMUSCULAR | ANDA | 24 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9859 | INJECTION, POWDER, FOR SOLUTION | 250 mg | INTRAMUSCULAR | ANDA | 24 sections |
CEFTRIAXONE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3153 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 27 sections |
CEFTRIAXONE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3155 | INJECTION, SOLUTION | 2 g | INTRAVENOUS | NDA | 27 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-5002 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | ANDA | 23 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-5002 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | ANDA | 23 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-5003 | INJECTION, SOLUTION | 2 g | INTRAVENOUS | ANDA | 23 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-5003 | INJECTION, SOLUTION | 2 g | INTRAVENOUS | ANDA | 23 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7332 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 24 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7332 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 24 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7332 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 24 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7332 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 24 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7333 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 21 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7333 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 21 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7333 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 21 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7333 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 21 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7334 | INJECTION, POWDER, FOR SOLUTION | 10 g | INTRAVENOUS | ANDA | 25 sections |