ceftriaxone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, cefalosporanic acid derivatives 564 73384-59-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ceftriaxone sodium hydrate
  • ceftriaxone
  • biotrakson
  • rocefin
  • rocephalin
  • rophex
  • ceftriaxone sodium
A broad-spectrum cephalosporin antibiotic and cefotaxime derivative with a very long half-life and high penetrability to meninges, eyes and inner ears.
  • Molecular weight: 554.57
  • Formula: C18H18N8O7S3
  • CLOGP: -1.24
  • LIPINSKI: 2
  • HAC: 15
  • HDO: 4
  • TPSA: 208.98
  • ALOGS: -3.72
  • ROTB: 8
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2 g P
2 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 400 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 46 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 120.27 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 0 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.12 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.22 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.10 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 21, 1984 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 711.66 12.18 385 43861 29919 56217902
Acute generalised exanthematous pustulosis 400.38 12.18 182 44064 9687 56238134
Toxic epidermal necrolysis 387.79 12.18 232 44014 21810 56226011
Acute kidney injury 351.22 12.18 656 43590 240107 56007714
Pseudocholelithiasis 323.03 12.18 53 44193 3 56247818
Rheumatoid arthritis 264.69 12.18 8 44238 382596 55865225
Rash maculo-papular 258.08 12.18 200 44046 28707 56219114
Eosinophilia 257.31 12.18 173 44073 19904 56227917
Multiple organ dysfunction syndrome 239.25 12.18 249 43997 52521 56195300
Fatigue 230.90 12.18 171 44075 788381 55459440
Off label use 208.93 12.18 926 43320 555254 55692567
Jarisch-Herxheimer reaction 204.35 12.18 48 44198 272 56247549
Pain 194.94 12.18 143 44103 663041 55584780
Joint swelling 190.25 12.18 9 44237 289791 55958030
Agranulocytosis 170.79 12.18 142 44104 22517 56225304
Pyrexia 170.51 12.18 715 43531 418058 55829763
Stevens-Johnson syndrome 168.69 12.18 141 44105 22522 56225299
Cholelithiasis 167.77 12.18 180 44066 39284 56208537
Cholestasis 163.21 12.18 149 44097 26764 56221057
Septic shock 159.36 12.18 217 44029 60618 56187203
Clostridium difficile colitis 155.05 12.18 124 44122 18614 56229207
Drug interaction 153.71 12.18 436 43810 209319 56038502
Alopecia 150.59 12.18 25 44221 293433 55954388
Hepatitis 147.75 12.18 160 44086 35281 56212540
Recalled product administered 146.61 12.18 40 44206 444 56247377
Electrocardiogram QT prolonged 146.44 12.18 197 44049 54391 56193430
Premature delivery 145.24 12.18 140 44106 26920 56220901
Arthralgia 140.99 12.18 113 44133 501556 55746265
Haemolytic anaemia 139.99 12.18 90 44156 9595 56238226
Arthropathy 138.99 12.18 4 44242 200271 56047550
Tubulointerstitial nephritis 133.04 12.18 108 44138 16557 56231264
Drug intolerance 132.69 12.18 24 44222 264794 55983027
Abdominal discomfort 126.88 12.18 31 44215 277243 55970578
Factor V inhibition 126.16 12.18 29 44217 147 56247674
Anaphylactic shock 121.45 12.18 115 44131 21625 56226196
Headache 108.80 12.18 170 44076 558874 55688947
Therapeutic product effect decreased 108.77 12.18 6 44240 169446 56078375
Pemphigus 106.01 12.18 4 44242 157208 56090613
Glossodynia 105.93 12.18 3 44243 152455 56095366
Swelling 105.47 12.18 29 44217 239742 56008079
Hepatocellular injury 104.08 12.18 116 44130 26398 56221423
Postrenal failure 102.77 12.18 23 44223 101 56247720
Contraindicated product administered 102.14 12.18 13 44233 186273 56061548
Sepsis 101.63 12.18 290 43956 139550 56108271
Systemic lupus erythematosus 100.12 12.18 12 44234 180066 56067755
Status epilepticus 100.03 12.18 88 44158 15053 56232768
Leukocytosis 98.43 12.18 107 44139 23684 56224137
Exposure during pregnancy 94.50 12.18 278 43968 136064 56111757
Product dose omission issue 93.41 12.18 23 44223 204730 56043091
Weight increased 91.71 12.18 33 44213 229670 56018151
Encephalopathy 89.43 12.18 124 44122 35201 56212620
Acute respiratory distress syndrome 87.91 12.18 97 44149 21829 56225992
Respiratory failure 87.18 12.18 215 44031 94847 56152974
Fall 86.69 12.18 92 44154 357418 55890403
Hepatitis cholestatic 86.32 12.18 57 44189 6357 56241464
Peripheral swelling 83.58 12.18 40 44206 234686 56013135
Wound 82.99 12.18 7 44239 138797 56109024
Nasopharyngitis 81.24 12.18 36 44210 220923 56026898
Drug ineffective for unapproved indication 80.24 12.18 100 44146 25593 56222228
Pseudomembranous colitis 79.73 12.18 41 44205 2862 56244959
Thrombocytopenia 78.90 12.18 261 43985 135963 56111858
Drug-induced liver injury 77.01 12.18 114 44132 34348 56213473
Enterococcal infection 75.87 12.18 55 44191 7129 56240692
Clostridium difficile infection 75.73 12.18 100 44146 27098 56220723
Pericarditis 72.64 12.18 3 44243 108920 56138901
Altered state of consciousness 72.53 12.18 90 44156 22931 56224890
Cardiac arrest 71.62 12.18 188 44058 86126 56161695
Toxic encephalopathy 68.56 12.18 48 44198 5890 56241931
Long QT syndrome 66.37 12.18 37 44209 3039 56244782
Neutropenia 66.32 12.18 273 43973 157894 56089927
Pain in extremity 66.14 12.18 82 44164 297349 55950472
Haemophagocytic lymphohistiocytosis 65.98 12.18 57 44189 9515 56238306
Discomfort 64.48 12.18 16 44230 141745 56106076
Transaminases increased 64.03 12.18 95 44151 28675 56219146
Erythema 63.69 12.18 267 43979 155672 56092149
Bronchopulmonary aspergillosis 62.69 12.18 52 44194 8212 56239609
Dermatitis exfoliative 61.56 12.18 43 44203 5256 56242565
Musculoskeletal stiffness 61.24 12.18 23 44223 155984 56091837
Insomnia 60.57 12.18 38 44208 191822 56055999
Hypoxia 60.47 12.18 132 44114 53765 56194056
Injection site pain 59.93 12.18 10 44236 117108 56130713
Tachypnoea 59.68 12.18 67 44179 15363 56232458
Metabolic acidosis 59.64 12.18 111 44135 40343 56207478
Contusion 59.38 12.18 14 44232 128416 56119405
Linear IgA disease 59.31 12.18 26 44220 1267 56246554
Clostridium test positive 59.20 12.18 32 44214 2473 56245348
Choreoathetosis 59.19 12.18 20 44226 475 56247346
Pleocytosis 59.07 12.18 22 44224 699 56247122
Acinetobacter infection 58.56 12.18 27 44219 1483 56246338
Cholecystitis 58.10 12.18 64 44182 14371 56233450
Pneumococcal infection 58.03 12.18 19 44227 408 56247413
Dizziness 57.51 12.18 132 44114 376008 55871813
Alveolitis 54.55 12.18 31 44215 2642 56245179
Psoriasis 54.51 12.18 5 44241 92687 56155134
Tachycardia 54.41 12.18 195 44051 105681 56142140
Torsade de pointes 53.29 12.18 57 44189 12383 56235438
Myasthenia gravis crisis 52.51 12.18 18 44228 447 56247374
Pathogen resistance 52.40 12.18 41 44205 5959 56241862
Hydronephrosis 51.82 12.18 49 44197 9193 56238628
Low birth weight baby 50.87 12.18 41 44205 6217 56241604
Anaphylactic reaction 50.46 12.18 130 44116 58865 56188956
Cholangitis 50.25 12.18 37 44209 4912 56242909
Dermatitis bullous 49.99 12.18 44 44202 7529 56240292
Influenza B virus test positive 48.98 12.18 15 44231 257 56247564
No adverse event 48.93 12.18 96 44150 36278 56211543
Product use issue 48.31 12.18 45 44201 185996 56061825
Symmetrical drug-related intertriginous and flexural exanthema 47.87 12.18 16 44230 367 56247454
Renal failure 46.49 12.18 191 44055 110309 56137512
Psoriatic arthropathy 46.31 12.18 3 44243 74005 56173816
Rash morbilliform 46.08 12.18 29 44217 2978 56244843
SJS-TEN overlap 45.60 12.18 14 44232 242 56247579
Encephalitis 45.56 12.18 43 44203 8047 56239774
Infusion related reaction 43.93 12.18 60 44186 208871 56038950
Muscle spasms 43.63 12.18 27 44219 137344 56110477
Nausea 43.61 12.18 388 43858 763790 55484031
Weight decreased 43.12 12.18 77 44169 240637 56007184
Gait disturbance 43.00 12.18 39 44207 163282 56084539
Pyuria 42.96 12.18 23 44223 1744 56246077
Helicobacter infection 42.95 12.18 4 44242 73264 56174557
Cross sensitivity reaction 42.72 12.18 24 44222 2001 56245820
Pancytopenia 42.71 12.18 160 44086 88555 56159266
Acute respiratory failure 41.92 12.18 82 44164 30912 56216909
Urticaria 41.71 12.18 224 44022 144452 56103369
Drug resistance 41.70 12.18 65 44181 20477 56227344
Depression 40.68 12.18 49 44197 180068 56067753
Shock 40.33 12.18 66 44180 21662 56226159
Malaise 40.26 12.18 151 44095 367709 55880112
Lower respiratory tract infection 40.15 12.18 20 44226 114774 56133047
Stenotrophomonas infection 40.01 12.18 22 44224 1759 56246062
Nosocomial infection 39.96 12.18 21 44225 1533 56246288
Klebsiella infection 39.49 12.18 39 44207 7717 56240104
Neutrophilia 39.02 12.18 29 44217 3904 56243917
Guillain-Barre syndrome 38.88 12.18 28 44218 3592 56244229
Gastrointestinal disorder 38.87 12.18 20 44226 112682 56135139
Pneumonia 38.69 12.18 489 43757 406609 55841212
Pyelonephritis 38.69 12.18 55 44191 15969 56231852
Mobility decreased 38.16 12.18 15 44231 98976 56148845
Premature baby 37.92 12.18 60 44186 19145 56228676
COVID-19 pneumonia 37.56 12.18 45 44201 11057 56236764
Sinusitis 37.40 12.18 61 44185 197520 56050301
Haemodynamic instability 37.16 12.18 39 44207 8290 56239531
Treatment failure 36.76 12.18 48 44198 170344 56077477
Injection site erythema 36.67 12.18 8 44238 77440 56170381
Hepatic cytolysis 36.56 12.18 44 44202 10862 56236959
Hypertransaminasaemia 36.50 12.18 30 44216 4677 56243144
CSF oligoclonal band present 36.46 12.18 12 44234 262 56247559
Haemolysis 36.34 12.18 34 44212 6294 56241527
Death 35.52 12.18 143 44103 341283 55906538
Migraine 35.40 12.18 12 44234 86785 56161036
Normal newborn 35.17 12.18 36 44210 7434 56240387
Meningitis bacterial 35.03 12.18 18 44228 1254 56246567
Ill-defined disorder 34.73 12.18 6 44240 68537 56179284
Osteoarthritis 34.72 12.18 10 44236 80286 56167535
Enterobacter infection 34.51 12.18 21 44225 2031 56245790
Leukopenia 34.18 12.18 128 44118 70812 56177009
Stomatitis 34.06 12.18 27 44219 120783 56127038
Arthritis 34.02 12.18 18 44228 99834 56147987
Immune reconstitution inflammatory syndrome 33.57 12.18 31 44215 5643 56242178
International normalised ratio increased 33.56 12.18 93 44153 43948 56203873
Blood creatinine increased 33.24 12.18 138 44108 80053 56167768
Lip oedema 33.07 12.18 25 44221 3453 56244368
Angioedema 33.05 12.18 89 44157 41364 56206457
Leukaemoid reaction 32.56 12.18 10 44236 173 56247648
CSF measles antibody positive 32.48 12.18 8 44238 57 56247764
Maternal exposure during pregnancy 32.24 12.18 257 43989 189296 56058525
Folliculitis 32.23 12.18 3 44243 54976 56192845
Abdominal pain upper 31.95 12.18 57 44189 178256 56069565
Rubella antibody positive 31.67 12.18 8 44238 64 56247757
Respiratory distress 31.55 12.18 74 44172 31593 56216228
Oliguria 31.53 12.18 36 44210 8404 56239417
Rash erythematous 30.77 12.18 81 44165 37140 56210681
Cyanosis 30.67 12.18 49 44197 15761 56232060
Alanine aminotransferase increased 30.45 12.18 150 44096 93512 56154309
Aspartate aminotransferase increased 30.29 12.18 137 44109 82465 56165356
Blood lactic acid increased 29.96 12.18 30 44216 6034 56241787
Myopathy toxic 29.85 12.18 12 44234 470 56247351
Hypokalaemia 29.82 12.18 150 44096 94287 56153534
Foetal exposure during pregnancy 29.40 12.18 75 44171 33748 56214073
Hepatic function abnormal 29.39 12.18 76 44170 34482 56213339
Propofol infusion syndrome 29.19 12.18 14 44232 841 56246980
Partial seizures 29.12 12.18 28 44218 5362 56242459
Impaired healing 29.08 12.18 16 44230 86825 56160996
Blood brain barrier defect 28.98 12.18 8 44238 93 56247728
Hypertension 28.87 12.18 97 44149 244181 56003640
Intentional overdose 28.51 12.18 9 44237 68108 56179713
Laryngeal stenosis 28.31 12.18 14 44232 899 56246922
Pyelonephritis acute 28.27 12.18 25 44221 4304 56243517
Escherichia infection 28.01 12.18 40 44206 11659 56236162
Hepatic enzyme increased 27.90 12.18 58 44188 171326 56076495
Gastroenteritis clostridial 27.60 12.18 12 44234 573 56247248
Haemoperitoneum 27.46 12.18 20 44226 2610 56245211
Fibrin D dimer increased 27.21 12.18 25 44221 4522 56243299
Bile duct stone 27.09 12.18 22 44224 3372 56244449
Product use in unapproved indication 26.77 12.18 196 44050 140626 56107195
Autoimmune haemolytic anaemia 26.55 12.18 24 44222 4252 56243569
Vascular device infection 26.42 12.18 27 44219 5563 56242258
CSF protein increased 26.41 12.18 11 44235 472 56247349
Hypotension 26.39 12.18 307 43939 250201 55997620
Pelvic inflammatory disease 26.32 12.18 16 44230 1545 56246276
Intervertebral discitis 26.30 12.18 20 44226 2787 56245034
Factor V deficiency 25.88 12.18 7 44239 75 56247746
Systemic inflammatory response syndrome 25.87 12.18 26 44220 5252 56242569
Blood pressure increased 25.47 12.18 47 44199 145129 56102692
Bronchial obstruction 25.41 12.18 15 44231 1373 56246448
Neurotoxicity 25.38 12.18 45 44201 15750 56232071
Eosinophilic pneumonia 25.23 12.18 17 44229 1960 56245861
Unresponsive to stimuli 25.17 12.18 68 44178 31657 56216164
Face oedema 25.17 12.18 49 44197 18403 56229418
Weber tuning fork test abnormal 25.16 12.18 7 44239 84 56247737
Hepatitis infectious mononucleosis 25.08 12.18 7 44239 85 56247736
Anuria 24.97 12.18 38 44208 11722 56236099
Dermatitis exfoliative generalised 24.86 12.18 21 44225 3399 56244422
Drug abuse 24.84 12.18 11 44235 67599 56180222
Fibromyalgia 24.73 12.18 8 44238 59595 56188226
Myocardial infarction 24.64 12.18 22 44224 92848 56154973
Feeling abnormal 24.57 12.18 42 44204 133560 56114261
Renal tubular necrosis 24.44 12.18 36 44210 10792 56237029
Clostridium colitis 24.40 12.18 16 44230 1763 56246058
Hyporesponsive to stimuli 24.29 12.18 13 44233 985 56246836
Back pain 24.22 12.18 100 44146 237070 56010751
Thunderclap headache 24.12 12.18 8 44238 179 56247642
Myocarditis 23.78 12.18 32 44214 8826 56238995
Adverse event 23.75 12.18 7 44239 55369 56192452
Toxic skin eruption 23.62 12.18 37 44209 11702 56236119
Endocarditis 23.52 12.18 25 44221 5391 56242430
Organic brain syndrome 23.48 12.18 8 44238 195 56247626
Erythema multiforme 23.37 12.18 33 44213 9521 56238300
Cholestatic liver injury 23.23 12.18 17 44229 2235 56245586
Meningitis 23.05 12.18 27 44219 6477 56241344
Balance disorder 22.98 12.18 16 44230 76504 56171317
Hypoaesthesia 22.93 12.18 48 44198 141443 56106378
Bacteriuria 22.39 12.18 12 44234 912 56246909
Mitochondrial DNA mutation 22.37 12.18 9 44237 353 56247468
Electrolyte imbalance 22.34 12.18 46 44200 17987 56229834
Renal papillary necrosis 22.27 12.18 8 44238 229 56247592
Pulmonary function test abnormal 22.27 12.18 14 44232 1435 56246386
Abdominal wall haematoma 22.22 12.18 18 44228 2749 56245072
Jaundice 22.16 12.18 59 44187 27235 56220586
Multiple-drug resistance 22.14 12.18 21 44225 3953 56243868
Otitis media acute 22.07 12.18 12 44234 938 56246883
Sleep disorder 21.89 12.18 13 44233 67650 56180171
Dyspepsia 21.87 12.18 20 44226 83451 56164370
Haemostasis 21.85 12.18 8 44238 242 56247579
Cardiogenic shock 21.84 12.18 43 44203 16282 56231539
Suicidal ideation 21.84 12.18 9 44237 57733 56190088
Type I hypersensitivity 21.78 12.18 17 44229 2461 56245360
Nocardiosis 21.77 12.18 15 44231 1793 56246028
Chest X-ray abnormal 21.72 12.18 21 44225 4049 56243772
Nephropathy toxic 21.67 12.18 30 44216 8497 56239324
Haemodialysis 21.50 12.18 30 44216 8561 56239260
Disseminated intravascular coagulation 21.43 12.18 45 44201 17840 56229981
Pneumonia necrotising 21.35 12.18 9 44237 398 56247423
Dry mouth 21.25 12.18 12 44234 64193 56183628
Intravascular haemolysis 20.88 12.18 8 44238 275 56247546
Meningism 20.76 12.18 9 44237 427 56247394
Stress cardiomyopathy 20.70 12.18 29 44217 8307 56239514
Veillonella infection 20.63 12.18 5 44241 33 56247788
Agitation 20.58 12.18 93 44153 55943 56191878
Coagulation factor deficiency 20.56 12.18 4 44242 7 56247814
Palpitations 20.55 12.18 29 44217 99643 56148178
Multiple sclerosis relapse 20.53 12.18 5 44241 44898 56202923
Iris transillumination defect 20.39 12.18 6 44240 89 56247732
Mixed liver injury 20.39 12.18 20 44226 3924 56243897
Laryngeal mass 20.38 12.18 5 44241 35 56247786
Morganella infection 20.22 12.18 10 44236 642 56247179
Memory impairment 20.11 12.18 23 44223 86534 56161287
Aspergillus infection 20.09 12.18 27 44219 7438 56240383
Hyperglycaemia 20.06 12.18 71 44175 38210 56209611
Hepatosplenomegaly 19.90 12.18 16 44230 2417 56245404
Cholangitis acute 19.80 12.18 9 44237 478 56247343
Gene mutation 19.79 12.18 13 44233 1436 56246385
Hyperpyrexia 19.62 12.18 18 44228 3250 56244571
Hospitalisation 19.62 12.18 18 44228 74982 56172839
Eosinophilic pneumonia acute 19.60 12.18 8 44238 326 56247495
Clostridial infection 19.59 12.18 20 44226 4115 56243706
Inflammatory marker increased 19.48 12.18 24 44222 6066 56241755
Musculoskeletal pain 19.48 12.18 21 44225 81131 56166690
Septic pulmonary embolism 19.47 12.18 5 44241 43 56247778
Blood pressure fluctuation 19.45 12.18 4 44242 40356 56207465
Coagulation factor decreased 19.37 12.18 5 44241 44 56247777
Postpartum sepsis 19.32 12.18 4 44242 11 56247810
Respiratory acidosis 19.26 12.18 24 44222 6139 56241682
Blood gases abnormal 19.17 12.18 10 44236 719 56247102
Transverse sinus thrombosis 19.16 12.18 9 44237 516 56247305
Erythema nodosum 19.08 12.18 20 44226 4245 56243576
Conjunctival hyperaemia 19.04 12.18 15 44231 2201 56245620
Bronchopleural fistula 18.93 12.18 7 44239 218 56247603
Therapeutic product effect incomplete 18.89 12.18 34 44212 105997 56141824
Hyperthyroidism 18.88 12.18 36 44210 13316 56234505
Hyperbilirubinaemia 18.87 12.18 31 44215 10204 56237617
Encephalitis brain stem 18.87 12.18 6 44240 117 56247704
Acquired haemophilia 18.57 12.18 11 44235 1013 56246808
Red blood cell agglutination 18.45 12.18 3 44243 0 56247821
Anti factor V antibody 18.45 12.18 3 44243 0 56247821
Bacteraemia 18.34 12.18 39 44207 15592 56232229
Hypercreatininaemia 18.34 12.18 8 44238 385 56247436
Drug eruption 18.26 12.18 53 44193 25710 56222111
Anxiety 18.16 12.18 84 44162 193088 56054733
Influenza like illness 17.99 12.18 13 44233 60975 56186846
Cataract 17.80 12.18 9 44237 51238 56196583
Asymptomatic bacteriuria 17.61 12.18 7 44239 266 56247555
Cerebral artery stenosis 17.56 12.18 8 44238 427 56247394
Hypofibrinogenaemia 17.51 12.18 11 44235 1126 56246695
Unmasking of previously unidentified disease 17.30 12.18 10 44236 880 56246941
Infantile apnoea 17.29 12.18 10 44236 881 56246940
Cholecystitis acute 17.23 12.18 25 44221 7391 56240430
Normochromic anaemia 17.22 12.18 7 44239 282 56247539
Eyelid oedema 17.22 12.18 29 44217 9739 56238082
Bronchospasm 17.14 12.18 38 44208 15631 56232190
Toxicity to various agents 17.03 12.18 105 44141 224459 56023362
Skin test positive 17.02 12.18 9 44237 665 56247156
Hyperlactacidaemia 17.01 12.18 15 44231 2573 56245248
Confabulation 16.88 12.18 7 44239 297 56247524
Pseudophaeochromocytoma 16.82 12.18 5 44241 77 56247744
Hypoalbuminaemia 16.77 12.18 30 44216 10569 56237252
Injection site pruritus 16.75 12.18 6 44240 41925 56205896
Gamma-glutamyltransferase increased 16.67 12.18 58 44188 30947 56216874
Gastric disorder 16.62 12.18 3 44243 33207 56214614
Orthostatic hypotension 16.61 12.18 3 44243 33196 56214625
Foetal growth restriction 16.60 12.18 24 44222 7075 56240746
Inappropriate schedule of product administration 16.47 12.18 25 44221 83362 56164459
Relapsing fever 16.40 12.18 6 44240 181 56247640
Gastrooesophageal reflux disease 16.40 12.18 25 44221 83232 56164589
Antibiotic associated colitis 16.37 12.18 3 44243 3 56247818
Hepatitis acute 16.34 12.18 26 44220 8331 56239490
Brain abscess 16.33 12.18 13 44233 1936 56245885
Muscle tension dysphonia 16.31 12.18 5 44241 86 56247735
Vision blurred 16.25 12.18 25 44221 82918 56164903
Wound haemorrhage 16.23 12.18 14 44232 2331 56245490
Hyperthermia malignant 16.11 12.18 9 44237 742 56247079
Purpura 15.98 12.18 29 44217 10333 56237488
Foetal death 15.82 12.18 26 44220 8561 56239260
Pneumonia bacterial 15.73 12.18 25 44221 8003 56239818
Herpes zoster 15.72 12.18 22 44224 75867 56171954
Tracheobronchitis 15.63 12.18 10 44236 1057 56246764
Haematoma 15.60 12.18 58 44188 31961 56215860
Stress 15.57 12.18 14 44232 58896 56188925
Drug hypersensitivity 15.51 12.18 303 43943 274902 55972919
Stomatococcal infection 15.51 12.18 5 44241 102 56247719
Ear pruritus 15.42 12.18 15 44231 2913 56244908
Encephalitis autoimmune 15.35 12.18 11 44235 1400 56246421
Dry skin 15.31 12.18 9 44237 47100 56200721
Anaemia 15.24 12.18 295 43951 267216 55980605
Post treatment Lyme disease syndrome 15.16 12.18 3 44243 6 56247815
Hyperthermia 15.15 12.18 25 44221 8260 56239561
Anoxia 15.12 12.18 6 44240 227 56247594
Type IV hypersensitivity reaction 15.10 12.18 14 44232 2562 56245259
Procalcitonin increased 15.03 12.18 9 44237 846 56246975
Ear pain 15.01 12.18 3 44243 30887 56216934
Lemierre syndrome 14.95 12.18 5 44241 115 56247706
Candida test positive 14.89 12.18 9 44237 860 56246961
Visual impairment 14.89 12.18 22 44224 74180 56173641
Amoebic brain abscess 14.84 12.18 3 44243 7 56247814
Cerebral aspergillosis 14.68 12.18 7 44239 415 56247406
Pneumonia mycoplasmal 14.67 12.18 9 44237 883 56246938
Therapeutic response decreased 14.60 12.18 12 44234 52746 56195075
Ventricular dysfunction 14.54 12.18 14 44232 2685 56245136
Pneumonia pneumococcal 14.49 12.18 12 44234 1890 56245931
Condition aggravated 14.46 12.18 364 43882 344534 55903287
Anti-platelet antibody positive 14.45 12.18 4 44242 47 56247774
Amniotic cavity infection 14.42 12.18 10 44236 1208 56246613
Nephritis 14.41 12.18 13 44233 2296 56245525
Vitamin K deficiency 14.40 12.18 7 44239 433 56247388
Overlap syndrome 14.17 12.18 8 44238 673 56247148
Chemotherapeutic drug level increased 14.16 12.18 5 44241 136 56247685
Hypertensive heart disease 14.15 12.18 13 44233 2350 56245471
Normocytic anaemia 14.12 12.18 11 44235 1588 56246233
Fluid retention 14.12 12.18 13 44233 54065 56193756
Arthritis reactive 13.77 12.18 6 44240 288 56247533
Cystitis bacterial 13.76 12.18 5 44241 148 56247673
Arthritis bacterial 13.71 12.18 20 44226 5941 56241880
Pallor 13.71 12.18 46 44200 24103 56223718
Superior sagittal sinus thrombosis 13.69 12.18 8 44238 719 56247102
Ventricular fibrillation 13.64 12.18 28 44218 10924 56236897
Brain herniation 13.62 12.18 15 44231 3365 56244456
Thrombosis 13.58 12.18 16 44230 59411 56188410
Deafness bilateral 13.56 12.18 10 44236 1331 56246490
Platelet count increased 13.55 12.18 35 44211 15863 56231958
Erysipelas 13.50 12.18 22 44224 7191 56240630
Cardiac tamponade 13.45 12.18 17 44229 4409 56243412
Muscle haemorrhage 13.39 12.18 14 44232 2961 56244860
Hemianopia 13.36 12.18 9 44237 1037 56246784
Hypoxic-ischaemic encephalopathy 13.36 12.18 16 44230 3929 56243892
Blood urea increased 13.35 12.18 46 44200 24427 56223394
Diarrhoea infectious 13.33 12.18 9 44237 1041 56246780
Paraesthesia 13.33 12.18 55 44191 130459 56117362
Alpha 1 microglobulin increased 13.32 12.18 4 44242 64 56247757
Systemic candida 13.14 12.18 14 44232 3027 56244794
Blood creatine phosphokinase increased 13.10 12.18 50 44196 27902 56219919
Leukoencephalopathy 12.92 12.18 16 44230 4066 56243755
Ureterolithiasis 12.91 12.18 11 44235 1801 56246020
Multiple sclerosis 12.90 12.18 3 44243 27799 56220022
Microangiopathic haemolytic anaemia 12.88 12.18 7 44239 547 56247274
Generalised bullous fixed drug eruption 12.88 12.18 4 44242 72 56247749
Hyperkalaemia 12.81 12.18 76 44170 50789 56197032
Staphylococcus test positive 12.81 12.18 15 44231 3598 56244223
Suicide attempt 12.76 12.18 16 44230 57820 56190001
Bursitis 12.75 12.18 3 44243 27579 56220242
Acute hepatic failure 12.62 12.18 35 44211 16543 56231278
Electrocardiogram T wave abnormal 12.59 12.18 12 44234 2274 56245547
Coombs negative haemolytic anaemia 12.58 12.18 5 44241 190 56247631
Base excess 12.58 12.18 4 44242 78 56247743
Septic embolus 12.51 12.18 8 44238 845 56246976
Lactic acidosis 12.48 12.18 58 44188 35288 56212533
Generalised oedema 12.44 12.18 32 44214 14469 56233352
Central nervous system vasculitis 12.39 12.18 8 44238 858 56246963
Kidney enlargement 12.33 12.18 7 44239 595 56247226
Stridor 12.22 12.18 14 44232 3281 56244540
Respiratory disorder 12.20 12.18 56 44190 33901 56213920

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 515.43 12.35 1415 46819 345859 31303251
Drug reaction with eosinophilia and systemic symptoms 359.20 12.35 325 47909 29693 31619417
Postrenal failure 288.23 12.35 77 48157 368 31648742
Jarisch-Herxheimer reaction 266.68 12.35 73 48161 389 31648721
Pseudocholelithiasis 214.10 12.35 39 48195 0 31649110
Appendicolith 185.30 12.35 113 48121 5618 31643492
Rash maculo-papular 177.22 12.35 207 48027 25512 31623598
Acute generalised exanthematous pustulosis 174.83 12.35 111 48123 5929 31643181
Acute kidney injury 164.72 12.35 849 47385 278865 31370245
Fatigue 150.13 12.35 174 48060 335032 31314078
Appendicitis 146.66 12.35 129 48105 11336 31637774
Hepatocellular injury 144.43 12.35 171 48063 21373 31627737
Cholelithiasis 141.27 12.35 161 48073 19318 31629792
Cholestasis 140.71 12.35 182 48052 24893 31624217
Multiple organ dysfunction syndrome 137.87 12.35 314 47920 67889 31581221
Toxic epidermal necrolysis 134.25 12.35 157 48077 19367 31629743
Death 132.47 12.35 216 48018 360353 31288757
Eosinophilia 132.39 12.35 170 48064 23083 31626027
Cardiogenic shock 127.86 12.35 164 48070 22244 31626866
Hypertransaminasaemia 119.36 12.35 77 48157 4227 31644883
Pyrexia 118.22 12.35 828 47406 303012 31346098
Toxic encephalopathy 113.35 12.35 78 48156 4772 31644338
Product dose omission issue 107.98 12.35 16 48218 105570 31543540
Agranulocytosis 105.06 12.35 145 48089 21102 31628008
Anaphylactic shock 104.40 12.35 118 48116 14027 31635083
Drug abuse 103.19 12.35 8 48226 87750 31561360
Pathogen resistance 101.59 12.35 93 48141 8608 31640502
Hepatitis 96.46 12.35 142 48092 21924 31627186
Anaphylactic reaction 92.02 12.35 163 48071 29390 31619720
Ureterolithiasis 90.41 12.35 49 48185 1943 31647167
Dizziness 89.31 12.35 103 48131 199044 31450066
Depression 87.85 12.35 16 48218 90799 31558311
Long QT syndrome 85.37 12.35 50 48184 2306 31646804
Clostridium difficile colitis 85.12 12.35 106 48128 13950 31635160
Haemolytic anaemia 84.99 12.35 89 48145 9707 31639403
Recalled product administered 81.24 12.35 30 48204 466 31648644
Nocardiosis 81.01 12.35 56 48178 3451 31645659
Fall 78.39 12.35 101 48133 185988 31463122
Drug-induced liver injury 77.94 12.35 136 48098 24227 31624883
Weight increased 75.26 12.35 17 48217 82930 31566180
Bronchopulmonary aspergillosis 73.41 12.35 97 48137 13537 31635573
Kounis syndrome 72.29 12.35 43 48191 2041 31647069
Brain abscess 71.37 12.35 48 48186 2827 31646283
Immune reconstitution inflammatory syndrome 70.41 12.35 74 48160 8104 31641006
Drug ineffective for unapproved indication 68.58 12.35 108 48126 17682 31631428
Septic shock 68.51 12.35 239 47995 65919 31583191
Ventricular fibrillation 67.97 12.35 111 48123 18737 31630373
Haemolysis 67.00 12.35 68 48166 7148 31641962
Factor V inhibition 66.54 12.35 20 48214 156 31648954
Myocardial infarction 65.97 12.35 46 48188 113408 31535702
Alanine aminotransferase increased 63.38 12.35 253 47981 74403 31574707
Respiratory failure 62.87 12.35 313 47921 101136 31547974
COVID-19 pneumonia 60.51 12.35 85 48149 12570 31636540
Pain 60.15 12.35 121 48113 186638 31462472
Hydronephrosis 58.94 12.35 72 48162 9289 31639821
Tubulointerstitial nephritis 58.83 12.35 103 48131 18393 31630717
Ascites 56.97 12.35 164 48070 40849 31608261
Stress 56.16 12.35 120 48114 24821 31624289
Stevens-Johnson syndrome 55.59 12.35 97 48137 17275 31631835
Electrocardiogram QT prolonged 54.80 12.35 154 48080 37833 31611277
Insomnia 54.40 12.35 39 48195 94797 31554313
Hyponatraemia 48.78 12.35 232 48002 73567 31575543
Liver injury 48.02 12.35 79 48155 13413 31635697
Cerebrovascular accident 47.83 12.35 31 48203 79453 31569657
Klebsiella infection 47.49 12.35 59 48175 7744 31641366
Condition aggravated 47.44 12.35 418 47816 163591 31485519
Blood glucose increased 47.13 12.35 17 48217 61066 31588044
Anuria 47.04 12.35 66 48168 9748 31639362
Joint swelling 46.40 12.35 12 48222 53419 31595691
Acute respiratory distress syndrome 45.16 12.35 109 48125 24431 31624679
Transaminases increased 44.67 12.35 108 48126 24233 31624877
Disseminated intravascular coagulation 44.16 12.35 97 48137 20440 31628670
Anxiety 44.16 12.35 44 48190 90989 31558121
Hospitalisation 43.60 12.35 11 48223 49796 31599314
Sepsis 42.79 12.35 385 47849 151544 31497566
Toxicity to various agents 42.63 12.35 138 48096 181349 31467761
Cross sensitivity reaction 42.54 12.35 26 48208 1297 31647813
Candida infection 42.24 12.35 83 48151 16175 31632935
Abdominal discomfort 42.14 12.35 13 48221 51554 31597556
Disseminated cryptococcosis 41.88 12.35 26 48208 1334 31647776
Ureteral disorder 41.28 12.35 14 48220 167 31648943
Arthralgia 40.74 12.35 108 48126 151316 31497794
Inflammatory marker increased 39.94 12.35 40 48194 4138 31644972
Thrombocytopenia 39.81 12.35 361 47873 142386 31506724
Rash morbilliform 39.54 12.35 33 48201 2698 31646412
Pain in extremity 39.36 12.35 73 48161 116130 31532980
Cardiac failure congestive 37.78 12.35 39 48195 79348 31569762
Inappropriate schedule of product administration 37.78 12.35 15 48219 50808 31598302
Mucormycosis 36.96 12.35 44 48190 5526 31643584
Portal fibrosis 36.86 12.35 15 48219 306 31648804
Pruritus 36.67 12.35 320 47914 124847 31524263
Cryptococcal meningoencephalitis 36.59 12.35 12 48222 128 31648982
Asthenia 36.56 12.35 197 48037 224558 31424552
Bacterial pericarditis 35.25 12.35 10 48224 62 31649048
Hepatitis toxic 35.02 12.35 27 48207 1970 31647140
Nasopharyngitis 34.97 12.35 27 48207 63218 31585892
Product use in unapproved indication 34.69 12.35 264 47970 98907 31550203
Meningitis bacterial 34.47 12.35 22 48212 1185 31647925
Muscle spasms 34.31 12.35 32 48202 68286 31580824
Drug resistance 33.74 12.35 95 48139 23358 31625752
Diarrhoea 33.52 12.35 359 47875 352050 31297060
Feeling abnormal 33.25 12.35 23 48211 56979 31592131
Liver function test increased 33.14 12.35 65 48169 12649 31636461
Clostridium difficile infection 33.14 12.35 78 48156 17201 31631909
Torsade de pointes 32.73 12.35 46 48188 6804 31642306
Hepatitis cholestatic 32.69 12.35 47 48187 7099 31642011
Hepatic enzyme increased 32.31 12.35 124 48110 35784 31613326
Flank pain 32.17 12.35 43 48191 6066 31643044
Coronary artery disease 32.03 12.35 15 48219 46072 31603038
Cardiac disorder 31.84 12.35 10 48224 39204 31609906
Toxic skin eruption 31.47 12.35 56 48178 10124 31638986
Trichosporon infection 31.23 12.35 17 48217 680 31648430
Hyperferritinaemia 31.20 12.35 14 48220 366 31648744
Intentional overdose 31.11 12.35 12 48222 41377 31607733
Headache 30.94 12.35 159 48075 183493 31465617
Endocarditis 30.78 12.35 42 48192 6043 31643067
Fixed eruption 30.76 12.35 22 48212 1431 31647679
Hepatitis fulminant 30.66 12.35 33 48201 3713 31645397
Crying 30.40 12.35 40 48194 5557 31643553
Alcohol intolerance 30.15 12.35 14 48220 397 31648713
Choreoathetosis 29.93 12.35 19 48215 1014 31648096
Pseudomembranous colitis 29.89 12.35 28 48206 2667 31646443
Prostate cancer 29.80 12.35 10 48224 37591 31611519
Therapeutic product effect decreased 29.65 12.35 6 48228 31616 31617494
Myasthenia gravis crisis 29.34 12.35 15 48219 527 31648583
Blood phosphorus increased 29.07 12.35 35 48199 4447 31644663
Dehydration 29.04 12.35 89 48145 119022 31530088
Tachypnoea 29.03 12.35 72 48162 16411 31632699
Malignant mesenteric neoplasm 29.01 12.35 8 48226 44 31649066
Cerebral cyst 28.99 12.35 12 48222 256 31648854
Sphincter of Oddi dysfunction 28.99 12.35 10 48224 126 31648984
Hypoxia 28.86 12.35 152 48082 50161 31598949
Hepatomegaly 28.84 12.35 52 48182 9498 31639612
Gait disturbance 28.67 12.35 46 48188 77449 31571661
Encephalitis 28.54 12.35 43 48191 6772 31642338
Psoriasis 28.40 12.35 18 48216 46701 31602409
Leukocytosis 28.37 12.35 86 48148 22028 31627082
Procalcitonin increased 28.00 12.35 22 48212 1651 31647459
Acute hepatic failure 27.94 12.35 61 48173 12798 31636312
Urticaria 27.84 12.35 166 48068 57351 31591759
Hepatitis acute 27.62 12.35 42 48192 6667 31642443
Hypertension 27.61 12.35 101 48133 127999 31521111
Device related sepsis 27.58 12.35 27 48207 2717 31646393
Contusion 27.58 12.35 8 48226 33020 31616090
Hyper IgE syndrome 27.49 12.35 8 48226 55 31649055
Dry gangrene 27.19 12.35 13 48221 394 31648716
Corynebacterium infection 27.12 12.35 14 48220 502 31648608
Drug ineffective 27.09 12.35 790 47444 394783 31254327
Respiratory distress 27.08 12.35 112 48122 33441 31615669
Allergy test positive 27.01 12.35 7 48227 29 31649081
Hepatic function abnormal 26.78 12.35 129 48105 41093 31608017
Suicidal ideation 26.64 12.35 11 48223 36395 31612715
Clostridium test positive 26.53 12.35 25 48209 2399 31646711
Malignant neoplasm progression 26.40 12.35 50 48184 78948 31570162
Escherichia infection 26.30 12.35 43 48191 7261 31641849
Arthropathy 26.11 12.35 3 48231 24048 31625062
Aspartate aminotransferase increased 26.00 12.35 174 48060 62545 31586565
Neutropenia 25.99 12.35 327 47907 140037 31509073
Jaundice 25.95 12.35 103 48131 30184 31618926
Jejunal ulcer perforation 25.81 12.35 8 48226 70 31649040
COVID-19 25.76 12.35 157 48077 54664 31594446
Janeway lesion 25.44 12.35 6 48228 15 31649095
Drug intolerance 25.39 12.35 25 48209 52008 31597102
Metastases to stomach 25.22 12.35 8 48226 76 31649034
Drug interaction 25.05 12.35 451 47783 208092 31441018
Abdominal distension 24.99 12.35 147 48087 50537 31598573
Weight decreased 24.99 12.35 142 48092 159810 31489300
Cyanosis 24.74 12.35 55 48179 11680 31637430
Enterobacter infection 24.68 12.35 23 48211 2177 31646933
Oliguria 24.57 12.35 43 48191 7674 31641436
Wrong technique in product usage process 24.51 12.35 10 48224 33333 31615777
Pleocytosis 24.30 12.35 13 48221 502 31648608
Chest pain 24.04 12.35 94 48140 116863 31532247
Acute respiratory failure 23.71 12.35 95 48139 27960 31621150
Drug effective for unapproved indication 23.65 12.35 21 48213 1867 31647243
Intervertebral discitis 23.53 12.35 21 48213 1880 31647230
Crystalluria 23.49 12.35 12 48222 421 31648689
No adverse event 23.03 12.35 74 48160 19551 31629559
Malaise 23.00 12.35 156 48078 168355 31480755
Type IV hypersensitivity reaction 22.85 12.35 17 48217 1176 31647934
Syncope 22.69 12.35 61 48173 85121 31563989
Neurotoxicity 22.62 12.35 65 48169 16161 31632949
Mobility decreased 22.30 12.35 7 48227 27462 31621648
Omental necrosis 22.23 12.35 6 48228 30 31649080
Infective chondritis 21.97 12.35 5 48229 10 31649100
Balance disorder 21.95 12.35 15 48219 37407 31611703
Procalcitonin abnormal 21.93 12.35 11 48223 371 31648739
Coagulopathy 21.90 12.35 70 48164 18445 31630665
Neuropathy peripheral 21.83 12.35 52 48182 75597 31573513
Drug dependence 21.77 12.35 4 48230 22575 31626535
Eastern Cooperative Oncology Group performance status 21.76 12.35 6 48228 33 31649077
Cryptococcosis 21.64 12.35 22 48212 2316 31646794
Loss of personal independence in daily activities 21.60 12.35 8 48226 28280 31620830
Tissue infiltration 21.57 12.35 7 48227 72 31649038
Memory impairment 21.43 12.35 16 48218 38114 31610996
Incorrect dose administered 21.42 12.35 14 48220 35738 31613372
Muscle abscess 21.36 12.35 12 48222 511 31648599
Cataract 21.34 12.35 5 48229 23802 31625308
Diabetes mellitus 21.28 12.35 20 48214 42536 31606574
Coagulation factor decreased 21.23 12.35 7 48227 76 31649034
Blood alkaline phosphatase increased 21.21 12.35 95 48139 29358 31619752
Splenomegaly 21.06 12.35 57 48177 13692 31635418
Aspergillus infection 20.98 12.35 51 48183 11477 31637633
Peripheral swelling 20.93 12.35 45 48189 67820 31581290
Pulmonary physical examination abnormal 20.79 12.35 5 48229 14 31649096
Erythema 20.70 12.35 200 48034 80205 31568905
Gastrooesophageal reflux disease 20.65 12.35 13 48221 33858 31615252
Vision blurred 20.61 12.35 20 48214 41895 31607215
Antimicrobial susceptibility test resistant 20.53 12.35 10 48224 316 31648794
Pneumonia bacterial 20.31 12.35 47 48187 10249 31638861
Shock 20.20 12.35 78 48156 22567 31626543
Asthma 20.19 12.35 21 48213 42590 31606520
Red blood cell schistocytes present 20.14 12.35 9 48225 233 31648877
Angina pectoris 20.05 12.35 10 48224 29631 31619479
Liver transplant failure 20.02 12.35 7 48227 92 31649018
Back pain 19.98 12.35 92 48142 109321 31539789
Intracranial pressure increased 19.89 12.35 26 48208 3589 31645521
Vascular purpura 19.88 12.35 17 48217 1437 31647673
Low birth weight baby 19.84 12.35 37 48197 6933 31642177
Cholecystitis acute 19.83 12.35 33 48201 5654 31643456
Transient ischaemic attack 19.77 12.35 6 48228 24050 31625060
Faeces pale 19.57 12.35 16 48218 1271 31647839
Dyspnoea 19.56 12.35 387 47847 343092 31306018
Bile duct stone 19.45 12.35 21 48213 2371 31646739
Erectile dysfunction 19.44 12.35 3 48231 19232 31629878
Antinuclear antibody negative 19.43 12.35 5 48229 20 31649090
Overdose 19.41 12.35 65 48169 84599 31564511
Systemic candida 19.24 12.35 24 48210 3162 31645948
Encephalopathy 19.23 12.35 99 48135 32375 31616735
Suicide attempt 19.23 12.35 17 48217 37231 31611879
Erythema nodosum 19.06 12.35 15 48219 1128 31647982
Blood pressure increased 19.04 12.35 60 48174 79573 31569537
Serum sickness-like reaction 18.88 12.35 7 48227 110 31649000
Shock haemorrhagic 18.50 12.35 45 48189 10132 31638978
Drug eruption 18.19 12.35 65 48169 18122 31630988
Orthostatic hypotension 18.11 12.35 7 48227 24112 31624998
Interleukin-2 receptor increased 18.11 12.35 7 48227 124 31648986
Stomatitis 18.05 12.35 20 48214 39418 31609692
Antibiotic level below therapeutic 17.97 12.35 6 48228 68 31649042
Vitamin A deficiency 17.91 12.35 5 48229 29 31649081
Stenotrophomonas infection 17.81 12.35 18 48216 1882 31647228
Calculus urinary 17.73 12.35 15 48219 1249 31647861
Injection site pain 17.64 12.35 16 48218 34618 31614492
Haemophagocytic lymphohistiocytosis 17.48 12.35 48 48186 11630 31637480
Abdominal pain 17.27 12.35 315 47919 145637 31503473
Hyperamylasaemia 17.03 12.35 11 48223 605 31648505
Bronchopleural fistula 16.96 12.35 10 48224 467 31648643
Vanishing bile duct syndrome 16.95 12.35 11 48223 610 31648500
Osteomyelitis fungal 16.87 12.35 8 48226 238 31648872
ADAMTS13 activity decreased 16.75 12.35 6 48228 85 31649025
Infective spondylitis 16.72 12.35 8 48226 243 31648867
Renal papillary necrosis 16.71 12.35 7 48227 154 31648956
Prothrombin time ratio decreased 16.60 12.35 9 48225 357 31648753
Hypoaesthesia 16.57 12.35 38 48196 55984 31593126
Intentional product misuse 16.56 12.35 20 48214 37931 31611179
Hypofibrinogenaemia 16.54 12.35 16 48218 1587 31647523
Morganella infection 16.52 12.35 10 48224 490 31648620
Sleep apnoea syndrome 16.52 12.35 4 48230 18621 31630489
Rash 16.45 12.35 412 47822 201074 31448036
Colitis ulcerative 16.39 12.35 4 48230 18525 31630585
Cholangitis 16.35 12.35 37 48197 7949 31641161
Musculoskeletal pain 16.15 12.35 13 48221 29815 31619295
Contraindicated product administered 16.12 12.35 5 48229 19767 31629343
Erythema multiforme 16.09 12.35 37 48197 8034 31641076
Encephalomalacia 16.04 12.35 12 48222 837 31648273
Basal cell carcinoma 15.93 12.35 4 48230 18175 31630935
Herpes zoster reactivation 15.91 12.35 8 48226 271 31648839
Psychotic disorder 15.88 12.35 7 48227 22286 31626824
Unevaluable event 15.72 12.35 14 48220 30561 31618549
Hepatic cytolysis 15.72 12.35 44 48190 10779 31638331
Amnesia 15.67 12.35 8 48226 23394 31625716
Carotid artery insufficiency 15.55 12.35 4 48230 16 31649094
Arterial angioplasty 15.53 12.35 5 48229 50 31649060
Peritoneal dialysis 15.41 12.35 10 48224 554 31648556
Dry skin 15.23 12.35 10 48224 25471 31623639
Gamma-glutamyltransferase increased 15.22 12.35 83 48151 27742 31621368
Gonorrhoea 15.19 12.35 5 48229 54 31649056
Whipple's disease 15.17 12.35 4 48230 18 31649092
Coronavirus infection 15.08 12.35 23 48211 3660 31645450
Irritability 15.07 12.35 8 48226 22881 31626229
Neoplasm progression 15.03 12.35 6 48228 20266 31628844
Lymphopenia 15.01 12.35 52 48182 14277 31634833
Human T-cell lymphotropic virus type I infection 14.99 12.35 4 48230 19 31649091
Henoch-Schonlein purpura 14.99 12.35 15 48219 1550 31647560
Strongyloidiasis 14.97 12.35 19 48215 2547 31646563
Chondrocalcinosis 14.95 12.35 8 48226 309 31648801
Influenza 14.85 12.35 28 48206 44297 31604813
Pyelonephritis 14.84 12.35 29 48205 5627 31643483
Drug hypersensitivity 14.66 12.35 172 48062 72427 31576683
Red blood cell sedimentation rate decreased 14.64 12.35 5 48229 61 31649049
Glucose-6-phosphate dehydrogenase deficiency 14.50 12.35 6 48228 128 31648982
Palmar-plantar erythrodysaesthesia syndrome 14.38 12.35 3 48231 15480 31633630
Hypercreatininaemia 14.35 12.35 9 48225 470 31648640
Premature baby 14.33 12.35 60 48174 18006 31631104
Face oedema 14.29 12.35 42 48192 10574 31638536
General physical health deterioration 14.18 12.35 247 47987 113188 31535922
Cerebellar syndrome 14.09 12.35 17 48217 2164 31646946
Ocular icterus 14.08 12.35 19 48215 2704 31646406
Coagulation factor V level decreased 14.07 12.35 7 48227 232 31648878
Lung abscess 14.07 12.35 18 48216 2433 31646677
Metastases to heart 14.04 12.35 6 48228 139 31648971
Adverse event 14.03 12.35 4 48230 16701 31632409
White blood cell count decreased 13.95 12.35 77 48157 87321 31561789
Purpura 13.89 12.35 39 48195 9571 31639539
Influenza like illness 13.88 12.35 11 48223 25426 31623684
Hyperthermia 13.87 12.35 40 48194 9964 31639146
Altered state of consciousness 13.76 12.35 66 48168 20985 31628125
Meningitis candida 13.64 12.35 5 48229 76 31649034
Haemodynamic instability 13.59 12.35 36 48198 8539 31640571
Bronchial haemorrhage 13.58 12.35 10 48224 681 31648429
PO2 decreased 13.45 12.35 14 48220 1515 31647595
Tick-borne viral encephalitis 13.44 12.35 4 48230 30 31649080
Cardiac arrest 13.40 12.35 200 48034 88862 31560248
COVID-19 treatment 13.36 12.35 7 48227 259 31648851
Hypovolaemic shock 13.30 12.35 30 48204 6432 31642678
Lower respiratory tract infection 13.28 12.35 14 48220 28223 31620887
Erythema annulare 13.22 12.35 4 48230 32 31649078
Drug withdrawal syndrome 13.18 12.35 6 48228 18744 31630366
Enterococcal infection 13.18 12.35 36 48198 8695 31640415
Dermatitis exfoliative generalised 13.13 12.35 20 48214 3179 31645931
Hypocoagulable state 13.13 12.35 11 48223 904 31648206
Bacterial parotitis 13.11 12.35 4 48230 33 31649077
Distal intestinal obstruction syndrome 13.07 12.35 7 48227 271 31648839
Mechanical urticaria 13.02 12.35 5 48229 87 31649023
Polycystic liver disease 13.01 12.35 4 48230 34 31649076
Dysgeusia 12.99 12.35 10 48224 23456 31625654
SJS-TEN overlap 12.97 12.35 7 48227 275 31648835
Chorioretinitis 12.96 12.35 8 48226 406 31648704
Tremor 12.93 12.35 66 48168 76354 31572756
Pneumococcal infection 12.91 12.35 8 48226 409 31648701
Neuroborreliosis 12.90 12.35 4 48230 35 31649075
Listeriosis 12.87 12.35 11 48223 929 31648181
Dermatitis bullous 12.86 12.35 29 48205 6216 31642894
Urticarial vasculitis 12.80 12.35 4 48230 36 31649074
Migraine 12.66 12.35 3 48231 14177 31634933
Diabetic ketoacidosis 12.54 12.35 5 48229 16900 31632210
Ureteric obstruction 12.48 12.35 12 48222 1181 31647929

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 975.61 11.15 700 86046 57313 70784385
Off label use 721.17 11.15 2263 84483 740797 70100901
Pseudocholelithiasis 519.35 11.15 92 86654 6 70841692
Acute generalised exanthematous pustulosis 484.25 11.15 276 86470 15121 70826577
Acute kidney injury 463.25 11.15 1451 85295 473173 70368525
Toxic epidermal necrolysis 413.49 11.15 361 86385 39196 70802502
Rash maculo-papular 394.50 11.15 392 86354 50153 70791545
Postrenal failure 391.60 11.15 100 86646 504 70841194
Jarisch-Herxheimer reaction 374.28 11.15 102 86644 688 70841010
Multiple organ dysfunction syndrome 359.97 11.15 546 86200 107969 70733729
Eosinophilia 358.56 11.15 336 86410 39983 70801715
Fatigue 353.58 11.15 295 86451 824024 70017674
Rheumatoid arthritis 311.83 11.15 10 86736 291795 70549903
Cholelithiasis 299.18 11.15 328 86418 47012 70794686
Cholestasis 280.76 11.15 319 86427 47553 70794145
Pain 261.90 11.15 231 86515 628585 70213113
Completed suicide 257.26 11.15 4 86742 227131 70614567
Agranulocytosis 254.26 11.15 279 86467 40019 70801679
Hepatitis 246.72 11.15 305 86441 49675 70792023
Pyrexia 246.07 11.15 1420 85326 605532 70236166
Joint swelling 240.96 11.15 18 86728 253193 70588505
Clostridium difficile colitis 222.70 11.15 223 86523 28773 70812925
Hepatocellular injury 217.48 11.15 275 86471 45816 70795882
Haemolytic anaemia 214.20 11.15 172 86574 16622 70825076
Septic shock 209.11 11.15 439 86307 111819 70729879
Appendicolith 206.40 11.15 112 86634 5568 70836130
Anaphylactic shock 205.05 11.15 225 86521 32265 70809433
Arthralgia 185.09 11.15 206 86540 503184 70338514
Electrocardiogram QT prolonged 183.55 11.15 350 86396 83167 70758531
Toxic encephalopathy 175.67 11.15 126 86620 10280 70831418
Factor V inhibition 172.97 11.15 47 86699 313 70841385
Fall 167.33 11.15 178 86568 443918 70397780
Weight increased 161.35 11.15 48 86698 242283 70599415
Arthropathy 160.69 11.15 5 86741 150052 70691646
Product dose omission issue 160.29 11.15 35 86711 217433 70624265
Respiratory failure 160.15 11.15 512 86234 168223 70673475
Abdominal discomfort 157.30 11.15 35 86711 214623 70627075
Drug intolerance 155.26 11.15 42 86704 225645 70616053
Headache 155.05 11.15 297 86449 580108 70261590
Stevens-Johnson syndrome 154.92 11.15 205 86541 35702 70805996
Dizziness 152.58 11.15 207 86539 463934 70377764
Tubulointerstitial nephritis 152.30 11.15 195 86551 32881 70808817
Alopecia 148.21 11.15 31 86715 198459 70643239
Cardiogenic shock 147.05 11.15 201 86545 36106 70805592
Hypertransaminasaemia 143.48 11.15 105 86641 8838 70832860
Drug-induced liver injury 143.31 11.15 251 86495 55862 70785836
Synovitis 143.29 11.15 3 86743 129225 70712473
Long QT syndrome 142.45 11.15 86 86660 5241 70836457
Sepsis 142.08 11.15 634 86112 243911 70597787
Pathogen resistance 140.32 11.15 122 86624 13157 70828541
Drug interaction 140.28 11.15 871 85875 380570 70461128
Appendicitis 140.23 11.15 135 86611 16598 70825100
Bronchopulmonary aspergillosis 136.96 11.15 148 86598 20854 70820844
Therapeutic product effect decreased 136.45 11.15 10 86736 143008 70698690
Drug ineffective for unapproved indication 134.89 11.15 199 86547 38339 70803359
Nasopharyngitis 129.16 11.15 55 86691 222151 70619547
Pain in extremity 127.43 11.15 128 86618 327954 70513744
Clostridium test positive 118.91 11.15 74 86672 4762 70836936
Drug abuse 118.51 11.15 19 86727 147237 70694461
Peripheral swelling 117.45 11.15 72 86674 236491 70605207
Hydronephrosis 116.60 11.15 117 86629 15125 70826573
Acute respiratory distress syndrome 113.83 11.15 191 86555 41063 70800635
Contraindicated product administered 111.46 11.15 16 86730 134596 70707102
Insomnia 109.93 11.15 65 86681 217741 70623957
Nocardiosis 107.58 11.15 71 86675 5058 70836640
Leukocytosis 107.25 11.15 182 86564 39486 70802212
Immune reconstitution inflammatory syndrome 105.46 11.15 103 86643 12887 70828811
Thrombocytopenia 105.32 11.15 573 86173 238537 70603161
Depression 105.28 11.15 56 86690 198918 70642780
Premature delivery 103.47 11.15 129 86617 21175 70820523
Death 103.33 11.15 302 86444 509759 70331939
Ureterolithiasis 103.19 11.15 60 86686 3410 70838288
Hepatitis cholestatic 102.13 11.15 100 86646 12550 70829148
Contusion 101.95 11.15 17 86729 128019 70713679
Haemolysis 100.22 11.15 95 86651 11456 70830242
Transaminases increased 99.52 11.15 194 86552 46824 70794874
Pseudomembranous colitis 98.20 11.15 67 86679 5044 70836654
Anaphylactic reaction 96.64 11.15 254 86492 74720 70766978
COVID-19 pneumonia 94.10 11.15 125 86621 21844 70819854
Brain abscess 90.45 11.15 61 86685 4505 70837193
Swelling 88.64 11.15 61 86685 188478 70653220
Clostridium difficile infection 88.11 11.15 165 86581 38651 70803047
Malaise 86.42 11.15 258 86488 432674 70409024
Ventricular fibrillation 86.36 11.15 134 86612 26977 70814721
Wound 85.91 11.15 10 86736 98722 70742976
Encephalopathy 85.77 11.15 215 86531 61446 70780252
Glossodynia 85.57 11.15 5 86741 86482 70755216
Tachypnoea 84.94 11.15 137 86609 28501 70813197
Injection site pain 84.48 11.15 20 86726 117599 70724099
Status epilepticus 83.46 11.15 125 86621 24401 70817297
Klebsiella infection 83.34 11.15 95 86651 14197 70827501
Alanine aminotransferase increased 81.53 11.15 377 86369 147103 70694595
Neutropenia 80.86 11.15 565 86181 256591 70585107
Systemic lupus erythematosus 80.09 11.15 14 86732 101888 70739810
Drug resistance 78.91 11.15 156 86590 38034 70803664
Pemphigus 78.63 11.15 6 86740 83030 70758668
Choreoathetosis 78.63 11.15 38 86708 1478 70840220
Cross sensitivity reaction 77.48 11.15 50 86696 3428 70838270
Exposure during pregnancy 75.81 11.15 258 86488 87459 70754239
Discomfort 75.58 11.15 18 86728 105418 70736280
Pleocytosis 75.09 11.15 35 86711 1254 70840444
Rash morbilliform 74.12 11.15 58 86688 5397 70836301
Muscle spasms 73.52 11.15 49 86697 153997 70687701
Toxicity to various agents 73.22 11.15 232 86514 381940 70459758
Sinusitis 72.77 11.15 60 86686 169135 70672563
Hypoxia 72.46 11.15 265 86481 93079 70748619
Myocardial infarction 72.43 11.15 62 86684 171583 70670115
Musculoskeletal stiffness 70.52 11.15 47 86699 147713 70693985
Encephalitis 70.39 11.15 85 86661 13500 70828198
Gait disturbance 69.78 11.15 74 86672 185032 70656666
Mobility decreased 69.23 11.15 20 86726 102979 70738719
Enterococcal infection 68.74 11.15 87 86659 14495 70827203
Kounis syndrome 68.60 11.15 46 86700 3365 70838333
Anuria 68.06 11.15 101 86645 19552 70822146
Disseminated intravascular coagulation 67.92 11.15 136 86610 33462 70808236
Pneumococcal infection 67.41 11.15 29 86717 857 70840841
Haemophagocytic lymphohistiocytosis 65.37 11.15 99 86647 19513 70822185
Erythema 64.78 11.15 442 86304 199121 70642577
Lower respiratory tract infection 64.51 11.15 28 86718 111885 70729813
Cardiac arrest 64.32 11.15 374 86372 159460 70682238
Torsade de pointes 64.03 11.15 94 86652 18022 70823676
Product use in unapproved indication 63.52 11.15 453 86293 207025 70634673
Respiratory distress 63.26 11.15 178 86568 54472 70787226
Intentional overdose 62.77 11.15 21 86725 98414 70743284
Stomatitis 62.51 11.15 40 86706 128471 70713227
Cholangitis 61.05 11.15 73 86673 11476 70830222
Psoriasis 61.05 11.15 22 86724 98411 70743287
Myasthenia gravis crisis 60.87 11.15 28 86718 973 70840725
Hypertension 60.76 11.15 174 86572 295859 70545839
Anxiety 60.16 11.15 111 86635 220219 70621479
Altered state of consciousness 59.31 11.15 143 86603 39879 70801819
Meningitis bacterial 58.07 11.15 37 86709 2481 70839217
Endocarditis 57.76 11.15 66 86680 9888 70831810
Injection site erythema 57.34 11.15 10 86736 72914 70768784
Infusion related reaction 57.11 11.15 96 86650 197438 70644260
Blood pressure fluctuation 56.63 11.15 4 86742 59008 70782690
Nausea 56.49 11.15 720 86026 851368 69990330
Toxic skin eruption 56.48 11.15 94 86652 20068 70821630
Weight decreased 56.32 11.15 193 86553 310295 70531403
Enterobacter infection 54.80 11.15 43 86703 4017 70837681
Musculoskeletal pain 54.65 11.15 21 86725 90306 70751392
Inappropriate schedule of product administration 54.36 11.15 32 86714 107523 70734175
Ascites 54.30 11.15 194 86552 67353 70774345
Urticaria 54.02 11.15 363 86383 162686 70679012
Inflammatory marker increased 52.98 11.15 61 86685 9213 70832485
Migraine 52.43 11.15 12 86734 72226 70769472
Feeling abnormal 52.40 11.15 58 86688 142261 70699437
Dermatitis bullous 52.21 11.15 71 86675 12686 70829012
Hypoaesthesia 51.97 11.15 67 86679 153672 70688026
Stenotrophomonas infection 50.75 11.15 38 86708 3311 70838387
Linear IgA disease 50.72 11.15 36 86710 2888 70838810
Abdominal pain upper 50.69 11.15 100 86646 193502 70648196
Blood pressure increased 50.55 11.15 96 86650 188421 70653277
Hepatic function abnormal 50.22 11.15 190 86556 67806 70773892
Balance disorder 49.68 11.15 24 86722 90104 70751594
Mucormycosis 49.68 11.15 55 86691 7959 70833739
Cyanosis 49.40 11.15 96 86650 23110 70818588
Shock 49.09 11.15 134 86612 40291 70801407
Oliguria 48.78 11.15 75 86671 14976 70826722
Osteoarthritis 48.73 11.15 15 86731 74132 70767566
Escherichia infection 48.25 11.15 78 86668 16253 70825445
Bile duct stone 47.72 11.15 44 86702 5122 70836576
Neurotoxicity 46.83 11.15 109 86637 29717 70811981
Dermatitis exfoliative 46.67 11.15 61 86685 10490 70831208
Hepatic cytolysis 46.59 11.15 84 86662 19108 70822590
Jaundice 46.50 11.15 151 86595 49957 70791741
Ill-defined disorder 46.50 11.15 6 86740 54735 70786963
Blood cholesterol increased 46.35 11.15 11 86735 64593 70777105
Injection site reaction 46.09 11.15 4 86742 49848 70791850
Candida infection 45.64 11.15 118 86628 34355 70807343
Back pain 45.55 11.15 174 86572 270978 70570720
Intervertebral discitis 45.52 11.15 39 86707 4122 70837576
Hospitalisation 45.49 11.15 22 86724 82546 70759152
Aspartate aminotransferase increased 45.28 11.15 288 86458 126690 70715008
Helicobacter infection 45.17 11.15 7 86739 55649 70786049
Condition aggravated 45.13 11.15 754 85992 426881 70414817
Acinetobacter infection 45.03 11.15 32 86714 2572 70839126
Pericarditis 44.53 11.15 24 86722 84681 70757017
Cholecystitis 44.50 11.15 86 86660 20615 70821083
Trichosporon infection 43.63 11.15 22 86724 939 70840759
Renal failure 43.16 11.15 386 86360 188684 70653014
Cataract 42.95 11.15 8 86738 55637 70786061
Psoriatic arthropathy 42.75 11.15 13 86733 64758 70776940
Nosocomial infection 42.43 11.15 31 86715 2602 70839096
Acute respiratory failure 42.17 11.15 153 86593 53512 70788186
SJS-TEN overlap 41.68 11.15 18 86728 537 70841161
Fixed eruption 41.61 11.15 30 86716 2466 70839232
Haemodynamic instability 41.20 11.15 71 86675 15587 70826111
Pancytopenia 41.15 11.15 321 86425 150786 70690912
Metabolic acidosis 41.01 11.15 190 86556 74156 70767542
Leukopenia 40.69 11.15 246 86500 106314 70735384
Aspergillus infection 40.60 11.15 76 86670 17792 70823906
Disseminated cryptococcosis 40.57 11.15 26 86720 1761 70839937
Gastrooesophageal reflux disease 40.57 11.15 31 86715 90808 70750890
Symmetrical drug-related intertriginous and flexural exanthema 40.55 11.15 19 86727 689 70841009
Procalcitonin increased 40.35 11.15 30 86716 2586 70839112
Tachycardia 39.48 11.15 330 86416 158216 70683482
Arthritis 39.39 11.15 37 86709 97943 70743755
Hypofibrinogenaemia 39.03 11.15 26 86720 1881 70839817
Blood glucose increased 38.98 11.15 41 86705 102941 70738757
Fibromyalgia 38.90 11.15 6 86740 47868 70793830
Liver injury 38.38 11.15 124 86622 40911 70800787
Hepatitis toxic 38.33 11.15 37 86709 4562 70837136
Influenza B virus test positive 38.33 11.15 15 86731 346 70841352
Hepatomegaly 38.01 11.15 73 86673 17419 70824279
Renal papillary necrosis 37.97 11.15 15 86731 355 70841343
Folliculitis 37.81 11.15 4 86742 42566 70799132
Suicidal ideation 37.65 11.15 19 86727 69577 70772121
Hepatitis acute 37.65 11.15 64 86682 13898 70827800
Coagulation factor decreased 37.37 11.15 12 86734 151 70841547
Hepatitis fulminant 37.11 11.15 43 86703 6538 70835160
Bacterial pericarditis 36.75 11.15 10 86736 67 70841631
Palpitations 36.67 11.15 49 86697 110704 70730994
Splenomegaly 36.49 11.15 75 86671 18795 70822903
Dermatitis exfoliative generalised 36.32 11.15 42 86704 6372 70835326
Alcohol intolerance 36.30 11.15 15 86731 400 70841298
Cardiac failure congestive 36.28 11.15 69 86677 135388 70706310
Bronchopleural fistula 36.16 11.15 17 86729 621 70841077
Memory impairment 36.06 11.15 36 86710 92605 70749093
Drug eruption 35.73 11.15 118 86628 39378 70802320
Pneumonia bacterial 35.61 11.15 69 86677 16572 70825126
Erythema nodosum 35.38 11.15 35 86711 4446 70837252
Morganella infection 35.30 11.15 20 86726 1082 70840616
Liver function test increased 35.09 11.15 106 86640 33741 70807957
Acute hepatic failure 34.87 11.15 93 86653 27579 70814119
Orthostatic hypotension 34.85 11.15 10 86736 51733 70789965
Vision blurred 34.63 11.15 39 86707 94945 70746753
Product use issue 34.56 11.15 109 86637 179828 70661870
Renal tubular necrosis 34.55 11.15 83 86663 23088 70818610
Type IV hypersensitivity reaction 34.40 11.15 31 86715 3504 70838194
Dyspepsia 34.23 11.15 35 86711 89042 70752656
Wrong technique in product usage process 33.92 11.15 21 86725 68677 70773021
Cholecystitis acute 33.70 11.15 56 86690 11938 70829760
Erythema multiforme 33.41 11.15 67 86679 16497 70825201
Ureteral disorder 33.02 11.15 15 86731 506 70841192
Cerebrovascular accident 32.68 11.15 80 86666 143390 70698308
Coronary artery disease 32.65 11.15 18 86728 62718 70778980
Type 2 diabetes mellitus 32.63 11.15 7 86739 44073 70797625
Adverse event 32.51 11.15 10 86736 49451 70792247
Alveolitis 32.40 11.15 31 86715 3780 70837918
Systemic candida 32.18 11.15 38 86708 5896 70835802
Drug ineffective 32.02 11.15 1429 85317 938323 69903375
Cryptococcal meningoencephalitis 31.98 11.15 12 86734 246 70841452
Asthenia 31.98 11.15 382 86364 457284 70384414
Pyuria 31.90 11.15 24 86722 2106 70839592
Unresponsive to stimuli 31.86 11.15 137 86609 51794 70789904
Diarrhoea 31.85 11.15 723 86023 782618 70059080
Vascular device infection 31.81 11.15 44 86702 7986 70833712
COVID-19 31.79 11.15 230 86516 105527 70736171
Hypercreatininaemia 31.75 11.15 17 86729 822 70840876
Injection site swelling 31.65 11.15 7 86739 43150 70798548
Multiple sclerosis relapse 31.50 11.15 7 86739 43010 70798688
International normalised ratio increased 31.22 11.15 187 86559 80539 70761159
Pyelonephritis 31.11 11.15 69 86677 18220 70823478
Neutrophilia 30.78 11.15 41 86705 7180 70834518
Gastrointestinal disorder 30.67 11.15 51 86695 105376 70736322
Fluid retention 30.44 11.15 20 86726 63365 70778333
CSF oligoclonal band present 30.41 11.15 12 86734 283 70841415
Hyponatraemia 30.19 11.15 314 86432 159773 70681925
No adverse event 29.92 11.15 97 86649 32056 70809642
Gamma-glutamyltransferase increased 29.79 11.15 132 86614 50553 70791145
Loss of personal independence in daily activities 29.73 11.15 36 86710 84874 70756824
Therapeutic product effect incomplete 29.60 11.15 64 86682 119818 70721880
Influenza like illness 29.55 11.15 22 86724 65309 70776389
Injection site pruritus 29.49 11.15 6 86740 39204 70802494
Malignant mesenteric neoplasm 29.48 11.15 8 86738 53 70841645
CSF measles antibody positive 28.97 11.15 8 86738 57 70841641
Pruritus 28.97 11.15 588 86158 344972 70496726
Flank pain 28.62 11.15 65 86681 17437 70824261
Suicide attempt 28.60 11.15 33 86713 79477 70762221
Purpura 28.55 11.15 66 86680 17909 70823789
Autoimmune haemolytic anaemia 28.55 11.15 41 86705 7705 70833993
Anti factor V antibody 28.54 11.15 5 86741 0 70841698
Rubella antibody positive 28.50 11.15 8 86738 61 70841637
Crystalluria 28.35 11.15 16 86730 859 70840839
Cholestatic liver injury 28.28 11.15 30 86716 4138 70837560
Cerebral cyst 28.23 11.15 12 86734 344 70841354
Organic brain syndrome 28.22 11.15 13 86733 453 70841245
Portal fibrosis 28.15 11.15 14 86732 580 70841118
Herpes zoster 27.92 11.15 38 86708 85197 70756501
Intentional product misuse 27.60 11.15 34 86712 79561 70762137
Angioedema 27.50 11.15 157 86589 66453 70775245
Chest pain 27.50 11.15 187 86559 251073 70590625
Type I hypersensitivity 27.36 11.15 28 86718 3704 70837994
Hyperthermia 27.35 11.15 62 86684 16609 70825089
Drug effective for unapproved indication 27.34 11.15 31 86715 4604 70837094
Normal newborn 27.21 11.15 36 86710 6264 70835434
Rash erythematous 26.93 11.15 130 86616 51588 70790110
Muscle abscess 26.88 11.15 16 86730 950 70840748
Janeway lesion 26.75 11.15 6 86740 15 70841683
Device related sepsis 26.72 11.15 34 86712 5694 70836004
Rash 26.72 11.15 815 85931 509747 70331951
Impaired healing 26.61 11.15 31 86715 74343 70767355
Maternal exposure during pregnancy 26.56 11.15 236 86510 115109 70726589
Dry skin 26.39 11.15 18 86728 55913 70785785
Sphincter of Oddi dysfunction 26.36 11.15 12 86734 407 70841291
Haemostasis 26.26 11.15 11 86735 304 70841394
Systemic inflammatory response syndrome 26.15 11.15 47 86699 10665 70831033
Oropharyngeal pain 25.84 11.15 49 86697 96261 70745437
Leukaemoid reaction 25.67 11.15 11 86735 322 70841376
COVID-19 treatment 25.44 11.15 12 86734 442 70841256
Hepatosplenomegaly 25.42 11.15 33 86713 5637 70836061
Partial seizures 25.35 11.15 40 86706 8165 70833533
Gastric disorder 25.27 11.15 5 86741 33317 70808381
Hyperpyrexia 25.23 11.15 32 86714 5342 70836356
Blood phosphorus increased 25.19 11.15 36 86710 6734 70834964
Localised infection 25.09 11.15 5 86741 33153 70808545
Nervousness 25.06 11.15 4 86742 31116 70810582
Hyperferritinaemia 24.88 11.15 13 86733 598 70841100
Sleep apnoea syndrome 24.62 11.15 5 86741 32708 70808990
Coagulopathy 24.62 11.15 93 86653 33156 70808542
Pyelonephritis acute 24.56 11.15 32 86714 5485 70836213
Face oedema 24.45 11.15 78 86668 25561 70816137
Pneumonia 24.43 11.15 925 85821 595307 70246391
Jejunal ulcer perforation 24.27 11.15 8 86738 110 70841588
Lip oedema 24.26 11.15 32 86714 5551 70836147
Hip fracture 24.24 11.15 3 86743 28260 70813438
Lymphadenopathy 24.23 11.15 121 86625 48670 70793028
Blood alkaline phosphatase increased 24.20 11.15 138 86608 58383 70783315
Ureteric obstruction 24.18 11.15 22 86724 2517 70839181
Transient ischaemic attack 24.17 11.15 13 86733 45931 70795767
Procalcitonin abnormal 24.16 11.15 11 86735 373 70841325
Visual impairment 24.11 11.15 38 86708 80212 70761486
Hip arthroplasty 23.99 11.15 3 86743 28037 70813661
Peritoneal dialysis 23.86 11.15 14 86732 809 70840889
Blood creatinine increased 23.52 11.15 273 86473 142728 70698970
Pneumonia mycoplasmal 23.51 11.15 17 86729 1404 70840294
Neoplasm progression 23.50 11.15 13 86733 45215 70796483
Intentional self-injury 23.48 11.15 5 86741 31645 70810053
Otitis media acute 23.35 11.15 16 86730 1213 70840485
Pneumonia pneumococcal 23.32 11.15 25 86721 3489 70838209
Muscle injury 23.20 11.15 9 86737 38485 70803213
Fibrin D dimer increased 22.82 11.15 36 86710 7347 70834351
Encephalitis brain stem 22.82 11.15 9 86737 212 70841486
Interleukin-2 receptor increased 22.74 11.15 9 86737 214 70841484
Pelvic inflammatory disease 22.58 11.15 16 86730 1280 70840418
Obesity 22.58 11.15 3 86743 26768 70814930
Blood pressure systolic increased 22.57 11.15 22 86724 57237 70784461
Diabetes mellitus 22.55 11.15 33 86713 71791 70769907
Laryngeal stenosis 22.37 11.15 14 86732 910 70840788
Blood brain barrier defect 22.28 11.15 8 86738 144 70841554
Calculus urinary 22.20 11.15 19 86727 2005 70839693
Corynebacterium infection 22.16 11.15 15 86731 1114 70840584
Staphylococcal infection 22.13 11.15 126 86620 53278 70788420
Weber tuning fork test abnormal 22.10 11.15 7 86739 84 70841614
Sleep disorder 22.04 11.15 32 86714 69840 70771858
Chorioretinitis 21.89 11.15 14 86732 945 70840753
Pulmonary physical examination abnormal 21.88 11.15 5 86741 14 70841684
Hypoalbuminaemia 21.84 11.15 62 86684 19060 70822638
Hyperbilirubinaemia 21.83 11.15 69 86677 22499 70819199
Basal cell carcinoma 21.81 11.15 7 86739 33691 70808007
Factor V deficiency 21.73 11.15 7 86739 89 70841609
Eastern Cooperative Oncology Group performance status 21.70 11.15 6 86740 43 70841655
Multiple-drug resistance 21.55 11.15 35 86711 7320 70834378
Neck pain 21.55 11.15 30 86716 66627 70775071
Cholangitis acute 21.47 11.15 16 86730 1384 70840314
Omental necrosis 21.46 11.15 6 86740 45 70841653
Bronchospasm 21.43 11.15 69 86677 22723 70818975
Septic pulmonary embolism 21.35 11.15 6 86740 46 70841652
Empyema 21.25 11.15 25 86721 3862 70837836
Nephropathy toxic 21.12 11.15 60 86686 18454 70823244
Gastroenteritis clostridial 20.99 11.15 13 86733 829 70840869
Osteonecrosis of jaw 20.99 11.15 12 86734 40990 70800708
Normocytic anaemia 20.94 11.15 24 86722 3606 70838092
Vascular purpura 20.86 11.15 21 86725 2725 70838973
Sedation 20.79 11.15 16 86730 46715 70794983
Nasal congestion 20.79 11.15 30 86716 65642 70776056
Tick-borne viral encephalitis 20.71 11.15 8 86738 178 70841520
Decreased appetite 20.64 11.15 256 86490 304524 70537174
Antinuclear antibody negative 20.52 11.15 5 86741 20 70841678
Joint injury 20.51 11.15 4 86742 26928 70814770
Drug dependence 20.47 11.15 10 86736 37311 70804387
Strongyloidiasis 20.45 11.15 24 86722 3699 70837999
Hyperlactacidaemia 20.41 11.15 28 86718 5044 70836654
Influenza 20.36 11.15 71 86675 113629 70728069
Vitamin K deficiency 20.35 11.15 12 86734 700 70840998
Intracranial pressure increased 20.20 11.15 34 86712 7322 70834376
Sciatica 20.20 11.15 3 86743 24624 70817074
Tracheobronchitis 20.06 11.15 17 86729 1770 70839928
Serum sickness-like reaction 20.01 11.15 11 86735 561 70841137
Joint stiffness 19.95 11.15 9 86737 35167 70806531
Surgery 19.82 11.15 6 86740 29983 70811715
Liver transplant failure 19.81 11.15 7 86739 120 70841578
Pain in jaw 19.77 11.15 14 86732 42655 70799043
Neuropathy peripheral 19.66 11.15 84 86662 126812 70714886
Dysgeusia 19.53 11.15 19 86727 49483 70792215
Acquired haemophilia 19.49 11.15 17 86729 1840 70839858
Meningitis 19.48 11.15 37 86709 8756 70832942
Tooth disorder 19.45 11.15 3 86743 23935 70817763
Hepatitis infectious mononucleosis 19.40 11.15 7 86739 128 70841570
Generalised bullous fixed drug eruption 19.34 11.15 7 86739 129 70841569
CSF protein increased 19.34 11.15 14 86732 1158 70840540
Pneumonia necrotising 19.15 11.15 13 86733 970 70840728
Myopathy toxic 19.07 11.15 13 86733 977 70840721
Lymphopenia 19.01 11.15 75 86671 27284 70814414
Heart rate decreased 18.98 11.15 29 86717 61986 70779712
Iris transillumination defect 18.91 11.15 7 86739 138 70841560
Brain herniation 18.91 11.15 32 86714 6924 70834774
Infective chondritis 18.85 11.15 5 86741 30 70841668
Hypokalaemia 18.78 11.15 244 86502 130944 70710754
Endocarditis bacterial 18.77 11.15 15 86731 1439 70840259
Multiple sclerosis 18.75 11.15 4 86742 25281 70816417
Dry eye 18.72 11.15 8 86738 32274 70809424
Hypocoagulable state 18.60 11.15 17 86729 1956 70839742
Antibiotic level below therapeutic 18.51 11.15 6 86740 78 70841620
Bacteraemia 18.50 11.15 78 86668 29231 70812467
Dyspnoea exertional 18.44 11.15 43 86703 78387 70763311
Megacolon 18.43 11.15 21 86725 3135 70838563
Mitochondrial DNA mutation 18.39 11.15 9 86737 360 70841338
Thunderclap headache 18.36 11.15 8 86738 244 70841454
Depressed mood 18.26 11.15 16 86730 43804 70797894
Metastases to stomach 18.18 11.15 8 86738 250 70841448
Antibiotic associated colitis 18.13 11.15 4 86742 9 70841689
Guillain-Barre syndrome 18.02 11.15 34 86712 8006 70833692
Postpartum sepsis 17.83 11.15 4 86742 10 70841688
Skin test positive 17.79 11.15 13 86733 1091 70840607
Relapsing fever 17.76 11.15 9 86737 388 70841310
Pancreatitis acute 17.63 11.15 105 86641 45119 70796579
Cryptococcosis 17.62 11.15 21 86725 3289 70838409
Bacteriuria 17.51 11.15 13 86733 1118 70840580
Osteomyelitis fungal 17.50 11.15 8 86738 274 70841424
Veillonella infection 17.49 11.15 5 86741 41 70841657
Angina pectoris 17.49 11.15 20 86726 48363 70793335
Head injury 17.47 11.15 10 86736 34131 70807567
Ear pain 17.39 11.15 6 86740 27593 70814105
Amnesia 17.34 11.15 23 86723 52132 70789566
Blood pressure diastolic decreased 17.33 11.15 5 86741 25775 70815923
Mixed liver injury 17.32 11.15 29 86717 6220 70835478
Muscular weakness 17.16 11.15 99 86647 138237 70703461
Red blood cell agglutination 17.12 11.15 3 86743 0 70841698
Renal impairment 17.09 11.15 259 86487 143678 70698020
Flatulence 17.08 11.15 13 86733 38168 70803530
Henoch-Schonlein purpura 17.00 11.15 18 86728 2477 70839221
Cerebellar syndrome 16.86 11.15 26 86720 5205 70836493
Allergy test positive 16.78 11.15 9 86737 437 70841261
Meningitis aseptic 16.75 11.15 29 86717 6390 70835308
Bone marrow failure 16.74 11.15 110 86636 48900 70792798
Hypersensitivity vasculitis 16.74 11.15 30 86716 6792 70834906
Prothrombin time ratio decreased 16.71 11.15 11 86735 780 70840918
Eosinophilic pneumonia 16.68 11.15 25 86721 4880 70836818
Arterial angioplasty 16.61 11.15 5 86741 50 70841648
Gait inability 16.52 11.15 20 86726 47155 70794543
Propofol infusion syndrome 16.50 11.15 15 86731 1714 70839984
Clostridial infection 16.49 11.15 26 86720 5303 70836395
Dyspnoea 16.49 11.15 772 85974 769288 70072410
Pneumococcal sepsis 16.48 11.15 14 86732 1462 70840236
Bursitis 16.47 11.15 6 86740 26667 70815031
Thrombosis 16.43 11.15 43 86703 75362 70766336
Carotid artery insufficiency 16.41 11.15 4 86742 16 70841682
Hyperamylasaemia 16.37 11.15 12 86734 1012 70840686
Macule 16.37 11.15 18 86728 2585 70839113
Osteomyelitis 16.36 11.15 77 86669 30241 70811457
Syncope 16.34 11.15 127 86619 165582 70676116
Asthma 16.33 11.15 84 86662 120709 70720989
Bone pain 16.30 11.15 23 86723 50799 70790899
Accidental exposure to product 16.19 11.15 7 86739 28044 70813654
Meningism 16.17 11.15 10 86736 636 70841062
Diabetes insipidus 16.16 11.15 24 86722 4647 70837051
Antimicrobial susceptibility test resistant 16.09 11.15 8 86738 331 70841367
Lung consolidation 16.04 11.15 33 86713 8273 70833425
Viral infection 16.02 11.15 14 86732 38377 70803321
Overdose 15.86 11.15 132 86614 169613 70672085
Pulmonary necrosis 15.83 11.15 9 86737 490 70841208
Abdominal wall haematoma 15.67 11.15 23 86723 4407 70837291
Dry mouth 15.48 11.15 40 86706 70417 70771281
Psychotic disorder 15.43 11.15 14 86732 37687 70804011
Vanishing bile duct syndrome 15.40 11.15 13 86733 1346 70840352
Incorrect dose administered 15.35 11.15 37 86709 66682 70775016
Delirium 15.33 11.15 149 86597 74465 70767233
Injection site haemorrhage 15.33 11.15 6 86740 25521 70816177
Ocular icterus 15.31 11.15 25 86721 5252 70836446
Dehydration 15.28 11.15 190 86556 225952 70615746
Cardiac disorder 15.27 11.15 31 86715 59384 70782314
Whipple's disease 15.22 11.15 4 86742 23 70841675
Hypertriglyceridaemia 15.19 11.15 40 86706 11771 70829927
Eosinophilic pneumonia acute 15.15 11.15 11 86735 914 70840784
Pneumonia staphylococcal 15.02 11.15 23 86723 4575 70837123
Blood fibrinogen increased 15.00 11.15 14 86732 1655 70840043
Dysstasia 14.98 11.15 6 86740 25173 70816525
Embolia cutis medicamentosa 14.93 11.15 9 86737 547 70841151
Haemodialysis 14.92 11.15 51 86695 17315 70824383
Laryngeal mass 14.89 11.15 5 86741 73 70841625
Encephalomalacia 14.81 11.15 12 86734 1174 70840524
Foot fracture 14.74 11.15 3 86743 19597 70822101
Prostate cancer 14.74 11.15 10 86736 31153 70810545
Coronavirus infection 14.71 11.15 27 86719 6225 70835473
Red blood cell schistocytes present 14.66 11.15 9 86737 565 70841133
Blood lactate dehydrogenase increased 14.63 11.15 83 86663 35044 70806654
Respiratory acidosis 14.45 11.15 36 86710 10245 70831453
Platelet count increased 14.43 11.15 56 86690 20217 70821481
ADAMTS13 activity decreased 14.38 11.15 6 86740 164 70841534
Vitamin A deficiency 14.25 11.15 5 86741 84 70841614
Hypovolaemic shock 14.24 11.15 37 86709 10800 70830898
Histoplasmosis disseminated 14.23 11.15 15 86731 2053 70839645
Toxic shock syndrome 14.21 11.15 11 86735 1007 70840691
Pollakiuria 14.21 11.15 12 86734 33449 70808249
Oral pain 14.19 11.15 9 86737 29057 70812641
Amniotic cavity infection 14.08 11.15 10 86736 803 70840895
Lung abscess 14.07 11.15 20 86726 3724 70837974
Sinus disorder 14.05 11.15 3 86743 18956 70822742
Transverse sinus thrombosis 14.00 11.15 9 86737 613 70841085
Gonorrhoea 13.99 11.15 6 86740 176 70841522
Arthritis bacterial 13.93 11.15 31 86715 8202 70833496
Palmar-plantar erythrodysaesthesia syndrome 13.92 11.15 10 86736 30237 70811461
Central nervous system vasculitis 13.90 11.15 12 86734 1281 70840417
Rash macular 13.87 11.15 65 86681 25479 70816219
Metastases to bone 13.87 11.15 5 86741 22371 70819327
Lymphocyte transformation test positive 13.87 11.15 4 86742 34 70841664
Post treatment Lyme disease syndrome 13.84 11.15 3 86743 6 70841692
Pseudophaeochromocytoma 13.83 11.15 5 86741 92 70841606
Haemorrhoids 13.82 11.15 7 86739 25581 70816117
Localised oedema 13.77 11.15 29 86717 7392 70834306
Cardiac ventricular thrombosis 13.74 11.15 13 86733 1563 70840135
Streptococcal infection 13.73 11.15 30 86716 7841 70833857
Septic embolus 13.72 11.15 14 86732 1846 70839852
Fungal peritonitis 13.71 11.15 11 86735 1061 70840637
Cardiac valve abscess 13.66 11.15 4 86742 36 70841662
Bacterial parotitis 13.66 11.15 4 86742 36 70841662
Haematuria traumatic 13.53 11.15 6 86740 191 70841507
Amoebic brain abscess 13.52 11.15 3 86743 7 70841691
Unevaluable event 13.52 11.15 27 86719 52036 70789662
Epistaxis 13.52 11.15 72 86674 102555 70739143
Foetal death 13.51 11.15 26 86720 6213 70835485
Tubulointerstitial nephritis and uveitis syndrome 13.48 11.15 7 86739 318 70841380
Heart rate irregular 13.47 11.15 10 86736 29733 70811965
Hypotension 13.47 11.15 614 86132 403767 70437931
Acidosis 13.45 11.15 51 86695 18212 70823486
Infective spondylitis 13.41 11.15 8 86738 477 70841221
Encephalitis autoimmune 13.40 11.15 15 86731 2196 70839502
Bronchial obstruction 13.38 11.15 16 86730 2514 70839184
Rash pustular 13.35 11.15 35 86711 10273 70831425
Dry gangrene 13.28 11.15 10 86736 879 70840819
Hyper IgE syndrome 13.23 11.15 8 86738 489 70841209
Endotracheal intubation 13.17 11.15 21 86725 4325 70837373
Tetany 13.17 11.15 15 86731 2239 70839459
Hemianopia 13.14 11.15 13 86733 1652 70840046
Anoxia 13.08 11.15 7 86739 338 70841360
Therapeutic response decreased 12.99 11.15 33 86713 58420 70783278
POEMS syndrome 12.95 11.15 4 86742 44 70841654
Hepatic necrosis 12.92 11.15 31 86715 8615 70833083
Red blood cell sedimentation rate increased 12.88 11.15 17 86729 38625 70803073
Type IIa hyperlipidaemia 12.88 11.15 7 86739 349 70841349
Dysmetria 12.88 11.15 10 86736 920 70840778
Respiratory disorder 12.87 11.15 87 86659 39036 70802662
Shock haemorrhagic 12.87 11.15 50 86696 18056 70823642
Petechiae 12.87 11.15 52 86694 19120 70822578
Multisystem inflammatory syndrome in children 12.86 11.15 4 86742 45 70841653
Intravascular haemolysis 12.80 11.15 9 86737 711 70840987
Hepatic failure 12.80 11.15 117 86629 57508 70784190
Haemoperitoneum 12.79 11.15 20 86726 4051 70837647
Illness 12.78 11.15 12 86734 31779 70809919
Conjunctival hyperaemia 12.71 11.15 20 86726 4073 70837625
Listeriosis 12.69 11.15 14 86732 2018 70839680
Myocarditis 12.64 11.15 51 86695 18742 70822956
Hot flush 12.63 11.15 26 86720 49558 70792140
Neuroborreliosis 12.63 11.15 5 86741 119 70841579
Malignant neoplasm progression 12.62 11.15 92 86654 121647 70720051
Limb injury 12.54 11.15 8 86738 25744 70815954
Haemorrhoids thrombosed 12.52 11.15 6 86740 229 70841469
Biliary dilatation 12.45 11.15 15 86731 2377 70839321
Chondrocalcinosis 12.44 11.15 9 86737 744 70840954
Eye pain 12.43 11.15 14 86732 34088 70807610
Glycosylated haemoglobin increased 12.40 11.15 3 86743 17388 70824310
Haemoglobinuria 12.40 11.15 9 86737 748 70840950
Cell death 12.33 11.15 20 86726 4180 70837518
Overlap syndrome 12.24 11.15 9 86737 763 70840935
Tuberculosis of genitourinary system 12.20 11.15 4 86742 54 70841644
Gastrointestinal mucormycosis 12.20 11.15 7 86739 388 70841310
Injury 12.18 11.15 40 86706 65205 70776493
Mechanical urticaria 12.15 11.15 7 86739 391 70841307
Pulmonary function test 12.12 11.15 3 86743 13 70841685
Serum ferritin increased 12.10 11.15 31 86715 8974 70832724
PO2 decreased 12.03 11.15 16 86730 2798 70838900
Panic attack 12.02 11.15 6 86740 22113 70819585
Necrosis 12.01 11.15 30 86716 8551 70833147
Urine potassium increased 11.94 11.15 3 86743 14 70841684
Staphylococcus test positive 11.91 11.15 24 86722 5930 70835768
Meningitis candida 11.91 11.15 5 86741 139 70841559
Skin discolouration 11.86 11.15 17 86729 37308 70804390
Coagulation factor V level decreased 11.82 11.15 8 86738 594 70841104
Azotaemia 11.80 11.15 28 86718 7725 70833973
Infection 11.78 11.15 184 86562 210601 70631097
Neuralgic amyotrophy 11.75 11.15 6 86740 263 70841435
Stress 11.73 11.15 131 86615 67835 70773863
Liver abscess 11.72 11.15 23 86723 5576 70836122
Liver disorder 11.71 11.15 121 86625 61447 70780251
Metastases to heart 11.69 11.15 6 86740 266 70841432
Osteopenia 11.67 11.15 3 86743 16694 70825004
Hypothyroidism 11.65 11.15 24 86722 45731 70795967
Periostosis 11.61 11.15 3 86743 16 70841682
Pseudomonas infection 11.56 11.15 50 86696 18944 70822754
Lemierre syndrome 11.49 11.15 5 86741 152 70841546
Ototoxicity 11.48 11.15 16 86730 2925 70838773
Normochromic anaemia 11.47 11.15 7 86739 435 70841263
Joint range of motion decreased 11.46 11.15 9 86737 26017 70815681
Subdural abscess 11.46 11.15 4 86742 66 70841632
Blood gases abnormal 11.45 11.15 10 86736 1084 70840614
Hypernatraemia 11.43 11.15 38 86708 12723 70828975
Neoplasm malignant 11.40 11.15 11 86735 28763 70812935
Injection site rash 11.37 11.15 3 86743 16407 70825291
Disturbance in attention 11.35 11.15 22 86724 42872 70798826
Gene mutation 11.33 11.15 14 86732 2277 70839421
Body temperature decreased 11.32 11.15 11 86735 28661 70813037
Pulmonary nocardiosis 11.31 11.15 9 86737 858 70840840
Muscle tension dysphonia 11.30 11.15 4 86742 69 70841629
Dependence on oxygen therapy 11.30 11.15 7 86739 447 70841251
Glaucoma 11.29 11.15 4 86742 18088 70823610
CD4 lymphocytes increased 11.29 11.15 6 86740 286 70841412
Wound haemorrhage 11.25 11.15 18 86728 3719 70837979
Alpha 1 microglobulin increased 11.25 11.15 4 86742 70 70841628
Lymphocyte morphology abnormal 11.22 11.15 9 86737 868 70840830
PCO2 decreased 11.22 11.15 16 86730 2988 70838710
Procedural pain 11.20 11.15 4 86742 18005 70823693

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01DD04 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Third-generation cephalosporins
ATC J01DD54 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Third-generation cephalosporins
ATC J01DD63 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Third-generation cephalosporins
FDA CS M0003827 Cephalosporins
FDA EPC N0000175488 Cephalosporin Antibacterial
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:35625 beta-lactamase inhibitors
CHEBI has role CHEBI:36047 antibacterial drugs
CHEBI has role CHEBI:88188 allergenic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Gonococcal meningitis indication 151004
Streptococcal meningitis indication 4510004 DOID:11574
Septicemia due to Escherichia coli indication 9323009
Bacterial septicemia indication 10001005 DOID:0040085
Staphylococcal meningitis indication 12166008
Gonorrhea indication 15628003 DOID:7551
Infection of skin AND/OR subcutaneous tissue indication 19824006
Acute gonococcal cervicitis indication 20943002 DOID:10615
Staphylococcal pneumonia indication 22754005
Streptococcal septicemia indication 29577008
Acute gonococcal urethritis indication 29864006
Pneumonia due to Streptococcus indication 34020007
Gonorrhea of rectum indication 42746002
Gonococcal infection of joint indication 44743006
Bacterial arthritis indication 48245008
Salmonella septicemia indication 49786009
Lower respiratory tract infection indication 50417007
Pneumococcal meningitis indication 51169003
Pneumonia due to Escherichia coli indication 51530003
Bacterial pneumonia indication 53084003 DOID:874
Klebsiella cystitis indication 60867007
Gonococcal endocarditis indication 61048000
Acute gonococcal endometritis indication 65295003 DOID:7527
Haemophilus influenzae pneumonia indication 70036007
Infection due to Escherichia coli indication 71057007
Bacterial infection due to Serratia indication 71120004
Rhinoscleroma indication 72409005 DOID:11336
Gonorrhea of pharynx indication 74372003
Endometritis indication 78623009 DOID:1002
Bacterial meningitis indication 95883001 DOID:9470
Infection of bone indication 111253001
Staphylococcal septicemia indication 111821004
Female genital tract infection indication 125585007
Infectious disease of abdomen indication 128070006
Infection due to Enterobacteriaceae indication 128945009
Bacterial infection due to Klebsiella pneumoniae indication 186435004
Meningococcal meningitis indication 192644005
Escherichia coli meningitis indication 192655005
Proteus pneumonia indication 195888009
Chancroid indication 266143009 DOID:13778
Escherichia coli urinary tract infection indication 301011002
Proteus urinary tract infection indication 301012009
Streptococcus pyogenes infection indication 302809008
Bacterial urinary infection indication 312124009
Infective otitis media indication 312218008
Infectious disorder of joint indication 363162000
Meningitis due to Klebsiella mobilis indication 420585007
Peptostreptococcus infection indication 135341000119101
Klebsiella Pneumoniae Osteomyelitis indication
Inflammatory Disease of Female Pelvic Organs indication
Proteus Mirabilis Osteomyelitis indication
Peptostreptococcus Peritonitis indication
Enterobacter Pneumonia indication
Proteus Joint Infection indication
Haemophilus Septic Arthritis indication
Skin and Skin Structure Serratia Infection indication
E. Coli Peritonitis indication
Prevention of Perioperative Infection indication
Haemophilus Influenzae Type B Infections indication
Adult Gonococcal Conjunctivitis indication
E. Coli Septic Arthritis indication
Haemophilus Septicemia indication
Disseminated Gonococcal Infection indication
Klebsiella Pneumoniae Peritonitis indication
H. Influenzae Meningitis indication
Prevention of Meningococcal Meningitis indication
Gram-Negative Aerobic Bacillary Pneumonia indication
Skin and Skin Structure Proteus Infection indication
Haemophilus Osteomyelitis indication
Haemophilus Parainfluenzae Pneumonia indication
Enterobacter Osteomyelitis indication
Streptococcal Joint Infection indication
Pelvic Inflammatory Disease with Neisseria Gonorrhea indication
Klebsiella Joint Infection indication
EnterobacterJoint Infection indication
Skin and Skin Structure Morganella Morganii Infection indication
Streptococcus Osteomyelitis indication
E. Coli Joint Infection indication
E. Coli Osteomyelitis indication
Pyrexia of unknown origin off-label use 7520000
Lyme disease off-label use 23502006 DOID:11729
Lyme arthritis off-label use 33937009
Pseudotuberculosis off-label use 36753006
Lyme carditis off-label use 77863005
Infection by Yersinia enterocolitica off-label use 80960004
Ventilator-acquired pneumonia off-label use 429271009
Lyme Disease of the Central Nervous System off-label use
Sexual Transmitted Disease Exposure from Sexual Assault off-label use
Disorder of gallbladder contraindication 39621005 DOID:0060262
Acute nephropathy contraindication 58574008
Hemolytic anemia contraindication 61261009 DOID:583
Disease of liver contraindication 235856003 DOID:409
Neonatal hyperbilirubinemia contraindication 281610001
Pseudomembranous enterocolitis contraindication 397683000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.65 acidic
pKa2 4.17 acidic
pKa3 13.31 acidic
pKa4 3.29 Basic
pKa5 0.93 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
D-amino-acid oxidase Enzyme IC50 5 CHEMBL
Alpha-synuclein Transporter Kd 6.28 CHEMBL
Peptidoglycan synthase FtsI Enzyme INHIBITOR IC50 6.14 WOMBAT-PK CHEMBL
Penicillin-binding protein 1A Enzyme INHIBITOR IC50 6.51 WOMBAT-PK CHEMBL
Penicillin-binding protein 1B Enzyme INHIBITOR IC50 5.74 WOMBAT-PK CHEMBL
Penicillin-binding protein 2 Enzyme INHIBITOR IC50 6.21 WOMBAT-PK CHEMBL

External reference:

IDSource
4019667 VUID
N0000147759 NUI
D00924 KEGG_DRUG
104376-79-6 SECONDARY_CAS_RN
203172 RXNORM
4017814 VANDF
4019667 VANDF
C0007561 UMLSCUI
CHEBI:29007 CHEBI
9F2 PDB_CHEM_ID
CHEMBL1200995 ChEMBL_ID
CHEMBL161 ChEMBL_ID
CHEMBL3183968 ChEMBL_ID
D002443 MESH_DESCRIPTOR_UI
DB01212 DRUGBANK_ID
5326 IUPHAR_LIGAND_ID
4923 INN_ID
75J73V1629 UNII
5479530 PUBCHEM_CID
1314 MMSL
4387 MMSL
69782 MMSL
d00052 MMSL
002734 NDDF
004849 NDDF
19841008 SNOMEDCT_US
33440000 SNOMEDCT_US
372670001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9678 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 26 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9678 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 26 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9768 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 23 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9856 INJECTION, POWDER, FOR SOLUTION 2 g INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9856 INJECTION, POWDER, FOR SOLUTION 2 g INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9857 INJECTION, POWDER, FOR SOLUTION 1 g INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9857 INJECTION, POWDER, FOR SOLUTION 1 g INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9858 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9858 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9859 INJECTION, POWDER, FOR SOLUTION 250 mg INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9859 INJECTION, POWDER, FOR SOLUTION 250 mg INTRAMUSCULAR ANDA 24 sections
CEFTRIAXONE AND DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0264-3153 INJECTION, SOLUTION 1 g INTRAVENOUS NDA 27 sections
CEFTRIAXONE AND DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0264-3155 INJECTION, SOLUTION 2 g INTRAVENOUS NDA 27 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0338-5002 INJECTION, SOLUTION 1 g INTRAVENOUS ANDA 23 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0338-5003 INJECTION, SOLUTION 2 g INTRAVENOUS ANDA 23 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7332 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7332 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7332 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7332 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7333 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 21 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7333 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 21 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7333 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 21 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7333 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 21 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7334 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 25 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7334 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 25 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7334 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 25 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7334 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 25 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7335 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7335 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7335 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 24 sections