ceftriaxone ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, cefalosporanic acid derivatives 564 73384-59-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ceftriaxone sodium hydrate
  • ceftriaxone
  • biotrakson
  • rocefin
  • rocephalin
  • rophex
  • ceftriaxone sodium
A broad-spectrum cephalosporin antibiotic and cefotaxime derivative with a very long half-life and high penetrability to meninges, eyes and inner ears.
  • Molecular weight: 554.57
  • Formula: C18H18N8O7S3
  • CLOGP: -1.24
  • LIPINSKI: 2
  • HAC: 15
  • HDO: 4
  • TPSA: 208.98
  • ALOGS: -3.72
  • ROTB: 8
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2 g P
2 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 400 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 46 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 120.27 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 0 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.12 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.22 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.10 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.60 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -1.986 Moderate 0.76
caco2-efflux Caco-2 efflux ratio (BA/AB) 2.818 Moderate 0.76
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.497 10^-6 cm/s Moderate 0.76
dh-clint Dog hepatocyte intrinsic clearance 1.932 uL/min/10^6 cells Moderate 0.76
dppb Dog plasma protein binding (% unbound) 50.290 % Moderate 0.76
fcs-ppb Fetal calf serum protein binding (% unbound) 28.100 % Moderate 0.76
herg hERG pIC50 4.135 pIC50 Moderate 0.76
hh-clint Human hepatocyte intrinsic clearance 1.963 uL/min/10^6 cells Moderate 0.76
hlm-clint Human liver microsomal intrinsic clearance 4.236 uL/min/mg protein Moderate 0.76
hppb Human plasma protein binding (% unbound) 21.590 % Moderate 0.76
kinase-safety-class ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MTOR,NTRK2,PDK1,PDK2,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 53
kinase-selectivity-class AXL,BRAF,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,JAK2,MAP2K6,MAP3K14,MAPK12,MAPK7,PIM3,PRKDC,STK33,TEK,TTK 18
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.662 Moderate 0.76
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.371 Moderate 0.76
mh-clint Mouse hepatocyte intrinsic clearance 6.823 Moderate 0.76
mppb Mouse plasma protein binding (% unbound) 49.140 Moderate 0.76
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.250 Moderate 0.76
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 32.720 % Moderate 0.76
rat-kpuu-brain Rat brain Kpuu 0.006 % Moderate 0.76
rh-clint Rat hepatocyte intrinsic clearance 1.774 uL/min/10^6 cells Moderate 0.76
rh-fuinc Rat hepatocyte fraction unbound in incubation 90.220 % Moderate 0.76
rppb Rat plasma protein binding (% unbound) 18.150 % Moderate 0.76
solubility-dd Solubility at pH 7.4 in DMSO 937.562 uM Moderate 0.76

Approvals:

DateAgencyCompanyOrphan
Dec. 21, 1984 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 937.09 12.78 485 57695 42273 90527994
Acute kidney injury 546.87 12.78 837 57343 319550 90250717
Eosinophilia 529.95 12.78 290 57890 28243 90542024
Acute generalised exanthematous pustulosis 462.24 12.78 209 57971 13494 90556773
Toxic epidermal necrolysis 439.93 12.78 269 57911 32259 90538008
Rash maculo-papular 381.15 12.78 268 57912 40665 90529602
Pseudocholelithiasis 375.41 12.78 60 58120 6 90570261
Multiple organ dysfunction syndrome 309.71 12.78 294 57886 68042 90502225
Joint swelling 275.76 12.78 11 58169 503289 90066978
Jarisch-Herxheimer reaction 273.14 12.78 62 58118 374 90569893
Clostridium difficile colitis 272.45 12.78 185 57995 26521 90543746
Pulmonary function test abnormal 269.96 12.78 91 58089 2648 90567619
Chest X-ray abnormal 269.82 12.78 107 58073 4975 90565292
Blood lactic acid increased 265.07 12.78 124 58056 8654 90561613
Clostridium test positive 253.26 12.78 104 58076 5297 90564970
Pain 250.29 12.78 167 58013 996174 89574093
Fatigue 241.72 12.78 232 57948 1153791 89416476
Stevens-Johnson syndrome 236.17 12.78 176 58004 29200 90541067
Septic shock 228.58 12.78 276 57904 83884 90486383
Ear pruritus 223.83 12.78 102 58078 6701 90563566
Alopecia 222.52 12.78 28 58152 495043 90075224
Agranulocytosis 221.40 12.78 182 57998 34820 90535447
Arthropathy 215.28 12.78 4 58176 366238 90204029
Premature delivery 205.24 12.78 182 57998 38580 90531687
Cholestasis 201.34 12.78 175 58005 36124 90534143
Arthralgia 197.26 12.78 129 58051 778393 89791874
Rheumatoid arthritis 194.94 12.78 9 58171 362605 90207662
Glossodynia 191.23 12.78 3 58177 321776 90248491
Pemphigus 190.36 12.78 4 58176 326860 90243407
Cholelithiasis 181.21 12.78 195 57985 52311 90517956
Drug interaction 180.88 12.78 485 57695 275968 90294299
Abdominal discomfort 175.69 12.78 45 58135 477283 90092984
Status epilepticus 171.98 12.78 122 58058 18752 90551515
Systemic lupus erythematosus 171.27 12.78 17 58163 361879 90208388
Tubulointerstitial nephritis 169.17 12.78 136 58044 25207 90545060
Haemolytic anaemia 169.09 12.78 101 58079 11596 90558671
Off label use 165.70 12.78 1240 56940 1101012 89469255
Electrocardiogram QT prolonged 159.37 12.78 214 57966 72242 90498025
Wound 158.14 12.78 9 58171 302971 90267296
Breath sounds abnormal 157.90 12.78 107 58073 15279 90554988
Encephalopathy 157.66 12.78 171 58009 46273 90523994
Pericarditis 154.60 12.78 4 58176 270147 90300120
Headache 154.32 12.78 197 57983 862549 89707718
Anaphylactic reaction 153.44 12.78 232 57948 87292 90482975
Weight increased 150.72 12.78 41 58139 417886 90152381
Nasal polyps 149.66 12.78 91 58089 10789 90559478
Cardiac arrest 149.45 12.78 253 57927 104682 90465585
Pyrexia 148.88 12.78 824 57356 659661 89910606
Therapeutic product effect decreased 148.78 12.78 7 58173 277564 90292703
Contraindicated product administered 146.45 12.78 17 58163 320122 90250145
Swelling 145.79 12.78 44 58136 419014 90151253
Vasculitis 145.60 12.78 119 58061 22574 90547693
Platelet count increased 143.63 12.78 114 58066 20745 90549522
Anaphylactic shock 143.11 12.78 136 58044 31481 90538786
Respiratory failure 142.24 12.78 265 57915 118153 90452114
Nasopharyngitis 141.16 12.78 43 58137 407061 90163206
Drug intolerance 136.98 12.78 58 58122 447533 90122734
Recalled product administered 134.00 12.78 40 58140 775 90569492
Peripheral swelling 133.86 12.78 49 58131 413057 90157210
Hepatocellular injury 133.81 12.78 126 58054 28832 90541435
Factor V inhibition 132.84 12.78 29 58151 142 90570125
Leukocytosis 132.15 12.78 129 58051 30861 90539406
Psoriatic arthropathy 132.09 12.78 3 58177 228332 90341935
Helicobacter infection 131.16 12.78 3 58177 226847 90343420
Drug ineffective for unapproved indication 130.31 12.78 186 57994 66458 90503809
Clostridium difficile infection 129.27 12.78 137 58043 36108 90534159
Rhinitis allergic 129.20 12.78 98 58082 16687 90553580
Upper-airway cough syndrome 129.11 12.78 94 58086 15041 90555226
Thrombocytopenia 122.38 12.78 352 57828 208373 90361894
Folliculitis 116.99 12.78 3 58177 204350 90365917
Type 2 diabetes mellitus 116.30 12.78 3 58177 203241 90367026
Full blood count abnormal 116.00 12.78 130 58050 36467 90533800
Sepsis 114.99 12.78 313 57867 179501 90390766
Pseudomembranous colitis 108.67 12.78 52 58128 3816 90566451
Hepatitis 106.63 12.78 175 58005 70564 90499703
Discomfort 104.48 12.78 24 58156 274311 90295956
Acute respiratory distress syndrome 103.31 12.78 109 58071 28577 90541690
Hypoxia 102.31 12.78 174 58006 72225 90498042
Fibromyalgia 102.10 12.78 8 58172 206261 90364006
Contusion 101.81 12.78 19 58161 251197 90319070
Musculoskeletal stiffness 99.75 12.78 33 58147 296499 90273768
Altered state of consciousness 98.21 12.78 111 58069 31421 90538846
Mobility decreased 97.36 12.78 21 58159 250713 90319554
Impaired healing 96.44 12.78 17 58163 234182 90336085
Ill-defined disorder 94.89 12.78 6 58174 184885 90385382
Insomnia 94.55 12.78 48 58132 333426 90236841
Exposure during pregnancy 93.73 12.78 351 57829 238059 90332208
Pain in extremity 93.34 12.78 91 58089 450438 90119829
Postrenal failure 92.58 12.78 23 58157 214 90570053
Product dose omission issue 92.09 12.78 36 58144 291651 90278616
Lacrimation increased 90.71 12.78 99 58081 26963 90543304
Transaminases increased 89.74 12.78 115 58065 37077 90533190
Gastrointestinal disorder 89.11 12.78 27 58153 256660 90313607
Neutropenia 88.30 12.78 331 57849 224573 90345694
Stomatitis 88.22 12.78 33 58147 274665 90295602
Lower respiratory tract infection 87.68 12.78 26 58154 250633 90319634
Hepatitis cholestatic 86.56 12.78 59 58121 8502 90561765
Blood potassium decreased 85.73 12.78 128 58052 47599 90522668
Enterococcal infection 85.10 12.78 62 58118 9929 90560338
Muscle spasms 84.75 12.78 28 58152 251855 90318412
Sneezing 82.74 12.78 99 58081 29770 90540497
Haemophagocytic lymphohistiocytosis 82.63 12.78 73 58107 15386 90554881
Sinusitis 81.15 12.78 61 58119 343027 90227240
Osteoarthritis 81.04 12.78 14 58166 195716 90374551
Infusion related reaction 80.87 12.78 89 58091 416691 90153576
Hepatic enzyme increased 80.48 12.78 68 58112 360668 90209599
Eye pruritus 80.06 12.78 96 58084 28931 90541336
Blood cholesterol increased 79.58 12.78 18 58162 207994 90362273
Fall 76.95 12.78 119 58061 481691 90088576
Hypoaesthesia 76.74 12.78 54 58126 314156 90256111
Migraine 75.86 12.78 15 58165 190377 90379890
Psoriasis 75.21 12.78 5 58175 147749 90422518
Metabolic acidosis 74.97 12.78 131 58049 55545 90514722
Shock 74.22 12.78 92 58088 28686 90541581
Toxic encephalopathy 74.13 12.78 54 58126 8645 90561622
Dizziness 73.50 12.78 169 58011 589115 89981152
Injection site pain 72.84 12.78 12 58168 173687 90396580
Dermatitis exfoliative 72.81 12.78 45 58135 5491 90564776
Long QT syndrome 72.07 12.78 40 58140 3997 90566270
Depression 71.65 12.78 53 58127 300548 90269719
Linear IgA disease 71.37 12.78 33 58147 2241 90568026
Pleocytosis 70.68 12.78 26 58154 982 90569285
Cholecystitis 69.05 12.78 69 58111 16971 90553296
Sleep disorder 68.41 12.78 21 58159 198009 90372258
Bursitis 68.37 12.78 4 58176 131650 90438617
Tachypnoea 68.04 12.78 76 58104 21233 90549034
Low birth weight baby 67.88 12.78 53 58127 9414 90560853
Choreoathetosis 67.67 12.78 22 58158 570 90569697
Erythema 67.60 12.78 309 57871 228937 90341330
Bronchopulmonary aspergillosis 67.35 12.78 57 58123 11341 90558926
Acute respiratory failure 67.14 12.78 108 58072 42810 90527457
Hypertension 66.56 12.78 120 58060 457412 90112855
Acinetobacter infection 65.72 12.78 30 58150 1978 90568289
Renal failure 65.49 12.78 209 57971 130798 90439469
Alveolitis 65.32 12.78 34 58146 2987 90567280
Dyspepsia 64.97 12.78 23 58157 198137 90372130
Malaise 64.58 12.78 179 58001 585807 89984460
Aspartate aminotransferase increased 64.57 12.78 178 58002 102759 90467508
Abdominal pain upper 64.55 12.78 71 58109 332603 90237664
Treatment failure 64.51 12.78 60 58120 303868 90266399
Product use issue 64.47 12.78 70 58110 329849 90240418
Tachycardia 64.31 12.78 235 57945 157438 90412829
Unresponsive to stimuli 63.88 12.78 99 58081 38022 90532245
Pathogen resistance 63.82 12.78 48 58132 8067 90562200
Hypotension 62.04 12.78 389 57791 325008 90245259
Memory impairment 61.15 12.78 25 58155 197219 90373048
Respiratory distress 60.92 12.78 98 58082 38848 90531419
Gait disturbance 60.70 12.78 47 58133 260449 90309818
Drug-induced liver injury 59.47 12.78 159 58021 90159 90480108
Torsade de pointes 58.82 12.78 60 58120 15122 90555145
Pancytopenia 58.42 12.78 190 57990 120073 90450194
Joint range of motion decreased 57.70 12.78 9 58171 135634 90434633
Blood creatinine increased 57.44 12.78 169 58011 101217 90469050
Road traffic accident 56.72 12.78 3 58177 107623 90462644
Drug ineffective 56.55 12.78 1221 56959 1383077 89187190
Cholangitis 55.41 12.78 42 58138 7140 90563127
Drug resistance 55.16 12.78 82 58098 30367 90539900
Pneumococcal infection 55.07 12.78 23 58157 1222 90569045
Musculoskeletal pain 54.24 12.78 21 58159 171230 90399037
Night sweats 53.75 12.78 9 58171 128757 90441510
Rash morbilliform 53.62 12.78 33 58147 3996 90566271
Leukopenia 53.40 12.78 164 58016 100546 90469721
Toxic skin eruption 53.37 12.78 58 58122 15716 90554551
Hepatic cytolysis 52.80 12.78 81 58099 30835 90539432
Autoimmune haemolytic anaemia 52.60 12.78 37 58143 5608 90564659
Encephalitis 52.49 12.78 49 58131 11085 90559182
Weight decreased 52.28 12.78 103 58077 379807 90190460
Haemodynamic instability 52.17 12.78 50 58130 11689 90558578
Chest discomfort 52.08 12.78 201 57979 138164 90432103
Dermatitis bullous 51.74 12.78 47 58133 10269 90559998
Influenza B virus test positive 50.92 12.78 15 58165 277 90569990
Hypokalaemia 50.60 12.78 192 57988 130924 90439343
Arthritis 50.59 12.78 22 58158 167293 90402974
Sciatica 49.96 12.78 4 58176 101378 90468889
Gait inability 49.74 12.78 16 58164 146440 90423827
Immune reconstitution inflammatory syndrome 49.69 12.78 39 58141 6980 90563287
International normalised ratio increased 49.57 12.78 100 58080 47216 90523051
Agitation 49.19 12.78 123 58057 66975 90503292
Premature baby 49.01 12.78 70 58110 25007 90545260
Pyelonephritis 48.44 12.78 64 58116 21252 90549015
Myasthenia gravis crisis 48.23 12.78 20 58160 1044 90569223
Injury 48.04 12.78 34 58146 197315 90372952
Cross sensitivity reaction 47.45 12.78 27 58153 2830 90567437
Cardiogenic shock 47.38 12.78 68 58112 24400 90545867
Dry mouth 47.10 12.78 30 58150 184029 90386238
Hydronephrosis 46.21 12.78 48 58132 12354 90557913
Angioedema 45.55 12.78 117 58063 64759 90505508
Alanine aminotransferase increased 45.42 12.78 173 58007 118165 90452102
Adverse event 45.22 12.78 10 58170 117408 90452859
Hepatic function abnormal 45.16 12.78 95 58085 46193 90524074
Stenotrophomonas infection 44.99 12.78 25 58155 2504 90567763
Oliguria 44.86 12.78 44 58136 10580 90559687
Hypercholesterolaemia 44.52 12.78 6 58174 100886 90469381
CSF oligoclonal band present 44.51 12.78 15 58165 436 90569831
Anaemia 43.86 12.78 381 57799 352421 90217846
Cyanosis 43.57 12.78 58 58122 19397 90550870
Infection 43.35 12.78 106 58074 361988 90208279
Wound infection 43.18 12.78 8 58172 106394 90463873
Haemolysis 43.13 12.78 39 58141 8471 90561796
No adverse event 43.06 12.78 118 58062 67864 90502403
Lower limb fracture 42.90 12.78 3 58177 85010 90485257
Neutrophilia 42.84 12.78 33 58147 5745 90564522
Urticaria 42.73 12.78 345 57835 312389 90257878
Guillain-Barre syndrome 42.44 12.78 30 58150 4582 90565685
Haemoperitoneum 42.19 12.78 27 58153 3501 90566766
Kounis syndrome 42.06 12.78 24 58156 2529 90567738
Sulphaemoglobinaemia 42.05 12.78 15 58165 518 90569749
Disseminated intravascular coagulation 41.91 12.78 60 58120 21478 90548789
Propofol infusion syndrome 40.68 12.78 19 58161 1320 90568947
Blood lactate dehydrogenase decreased 40.52 12.78 12 58168 226 90570041
Klebsiella infection 40.44 12.78 41 58139 10256 90560011
Prescribed overdose 40.35 12.78 7 58173 97618 90472649
Vanishing bile duct syndrome 40.24 12.78 19 58161 1353 90568914
Paraesthesia 39.74 12.78 62 58118 250264 90320003
Symmetrical drug-related intertriginous and flexural exanthema 39.69 12.78 17 58163 962 90569305
Injection site erythema 38.72 12.78 8 58172 98494 90471773
Analgesic therapy 38.67 12.78 15 58165 657 90569610
CSF measles antibody positive 38.49 12.78 9 58171 63 90570204
Pyuria 37.84 12.78 21 58159 2098 90568169
Rubella antibody positive 37.66 12.78 9 58171 70 90570197
Blood gases abnormal 37.36 12.78 16 58164 905 90569362
Hepatitis infectious mononucleosis 37.35 12.78 10 58170 128 90570139
Rash erythematous 37.32 12.78 109 58071 64995 90505272
Antacid therapy 36.99 12.78 15 58165 739 90569528
Face oedema 36.91 12.78 59 58121 23259 90547008
Appendicolith 36.86 12.78 15 58165 746 90569521
Mitochondrial DNA mutation 36.55 12.78 13 58167 445 90569822
Myopathy toxic 36.38 12.78 14 58166 600 90569667
Drug therapy 35.97 12.78 15 58165 794 90569473
Anticoagulant therapy 35.83 12.78 15 58165 802 90569465
Generalised bullous fixed drug eruption 35.53 12.78 12 58168 351 90569916
Anxiety 35.28 12.78 93 58087 309679 90260588
Stress cardiomyopathy 34.92 12.78 43 58137 13312 90556955
Neurotoxicity 34.92 12.78 55 58125 21412 90548855
Electrolyte imbalance 34.76 12.78 58 58122 23687 90546580
Nausea 34.47 12.78 504 57676 1109812 89460455
Jaundice 34.39 12.78 69 58111 32448 90537819
Partial seizures 34.32 12.78 32 58148 7228 90563039
Prescribed underdose 34.22 12.78 4 58176 75015 90495252
Weber tuning fork test abnormal 34.00 12.78 9 58171 110 90570157
Enterobacter infection 33.98 12.78 21 58159 2562 90567705
Hyperphosphataemia 33.83 12.78 24 58156 3687 90566580
Drug eruption 33.77 12.78 72 58108 35335 90534932
Muscle tension dysphonia 33.73 12.78 11 58169 288 90569979
Nephropathy toxic 33.42 12.78 41 58139 12647 90557620
Meningitis bacterial 33.38 12.78 18 58162 1699 90568568
Lip oedema 33.32 12.78 26 58154 4613 90565654
Systemic inflammatory response syndrome 33.29 12.78 30 58150 6486 90563781
Ventricular fibrillation 33.20 12.78 43 58137 14001 90556266
Blood brain barrier defect 31.82 12.78 9 58171 143 90570124
Bile duct stone 31.65 12.78 24 58156 4083 90566184
Fibrin D dimer increased 31.63 12.78 27 58153 5433 90564834
Nosocomial infection 31.56 12.78 18 58162 1895 90568372
SJS-TEN overlap 31.44 12.78 15 58165 1093 90569174
Maternal exposure during pregnancy 31.24 12.78 361 57819 359702 90210565
Hyperglycaemia 30.82 12.78 87 58093 50883 90519384
Multiple-drug resistance 30.61 12.78 31 58149 7745 90562522
Intentional overdose 30.55 12.78 11 58169 93823 90476444
Escherichia infection 30.52 12.78 44 58136 15851 90554416
Renal tubular necrosis 30.48 12.78 42 58138 14513 90555754
Lactic acidosis 30.39 12.78 86 58094 50377 90519890
Gastrooesophageal reflux disease 29.56 12.78 38 58142 166299 90403968
Visual impairment 29.42 12.78 25 58155 132340 90437927
Type I hypersensitivity 29.22 12.78 23 58157 4132 90566135
Back pain 29.16 12.78 105 58075 317070 90253197
Hyperbilirubinaemia 28.86 12.78 40 58140 13896 90556371
Pneumonia necrotising 28.78 12.78 12 58168 635 90569632
COVID-19 pneumonia 28.78 12.78 46 58134 18131 90552136
Obesity 28.67 12.78 16 58164 105491 90464776
Anuria 28.42 12.78 41 58139 14777 90555490
Hepatitis acute 28.38 12.78 35 58145 10852 90559415
Gastroenteritis clostridial 28.29 12.78 12 58168 663 90569604
Type IV hypersensitivity reaction 28.19 12.78 22 58158 3904 90566363
Leukaemoid reaction 28.03 12.78 9 58171 224 90570043
Clostridium colitis 27.85 12.78 17 58163 2028 90568239
Eosinophilic pneumonia 27.77 12.78 19 58161 2754 90567513
Foot deformity 27.66 12.78 3 58177 59648 90510619
Haemodialysis 27.58 12.78 31 58149 8716 90561551
Hospitalisation 27.50 12.78 25 58155 128075 90442192
Organic brain syndrome 27.40 12.78 9 58171 241 90570026
Endocarditis 27.35 12.78 28 58152 7085 90563182
Gene mutation 27.22 12.78 17 58163 2113 90568154
Dermatitis exfoliative generalised 27.11 12.78 25 58155 5568 90564699
Factor V deficiency 27.04 12.78 7 58173 78 90570189
Hypercreatininaemia 27.03 12.78 12 58168 741 90569526
Pelvic inflammatory disease 26.96 12.78 16 58164 1814 90568453
Bacteraemia 26.86 12.78 50 58130 22250 90548017
Cholestatic liver injury 26.67 12.78 21 58159 3776 90566491
Erythema multiforme 26.64 12.78 36 58144 12210 90558057
CSF protein increased 26.53 12.78 12 58168 774 90569493
Hepatosplenomegaly 26.37 12.78 19 58161 2990 90567277
Taste disorder 26.36 12.78 4 58176 61542 90508725
Laryngeal mass 26.32 12.78 6 58174 37 90570230
Neck pain 25.97 12.78 21 58159 113942 90456325
Cholangitis acute 25.94 12.78 11 58169 607 90569660
Laryngeal stenosis 25.93 12.78 14 58166 1325 90568942
Pancreatitis acute 25.80 12.78 61 58119 32054 90538213
Sputum purulent 25.80 12.78 14 58166 1338 90568929
Pyelonephritis acute 25.79 12.78 24 58156 5408 90564859
Cholecystitis acute 25.76 12.78 31 58149 9373 90560894
Bronchial obstruction 25.49 12.78 15 58165 1674 90568593
Intervertebral discitis 25.47 12.78 22 58158 4498 90565769
Aspergillus infection 25.37 12.78 33 58147 10790 90559477
Fixed eruption 25.16 12.78 15 58165 1715 90568552
Activated partial thromboplastin time prolonged 25.14 12.78 28 58152 7797 90562470
Hypertransaminasaemia 24.99 12.78 40 58140 15785 90554482
Meningitis 24.96 12.78 29 58151 8452 90561815
Amnesia 24.72 12.78 20 58160 108485 90461782
Abdominal wall haematoma 24.54 12.78 19 58161 3333 90566934
Rash pustular 24.49 12.78 28 58152 8021 90562246
Dry skin 24.45 12.78 13 58167 88060 90482207
Hallucination, visual 24.42 12.78 49 58131 23043 90547224
Eosinophilic pneumonia acute 24.40 12.78 11 58169 704 90569563
Meningism 24.06 12.78 10 58170 525 90569742
Joint stiffness 24.00 12.78 10 58170 78032 90492235
Thunderclap headache 24.00 12.78 9 58171 359 90569908
Haematoma 23.95 12.78 67 58113 38981 90531286
Inappropriate schedule of product administration 23.91 12.78 37 58143 149896 90420371
Blood creatine phosphokinase increased 23.51 12.78 61 58119 33962 90536305
Suicidal ideation 23.47 12.78 9 58171 73846 90496421
Hyporesponsive to stimuli 23.46 12.78 14 58166 1603 90568664
Balance disorder 23.26 12.78 17 58163 97063 90473204
Bronchospasm 23.17 12.78 45 58135 20664 90549603
Encephalitis brain stem 23.10 12.78 7 58173 143 90570124
Staphylococcal infection 23.03 12.78 76 58104 48363 90521904
Inflammatory marker increased 23.02 12.78 29 58151 9185 90561082
Bronchopleural fistula 22.92 12.78 8 58172 259 90570008
Encephalitis autoimmune 22.77 12.78 15 58165 2043 90568224
Condition aggravated 22.73 12.78 521 57659 595024 89975243
Wound haemorrhage 22.64 12.78 17 58163 2850 90567417
Cataract 22.56 12.78 9 58171 72083 90498184
Hyperpyrexia 22.53 12.78 21 58159 4740 90565527
Renal papillary necrosis 22.43 12.78 8 58172 276 90569991
Feeling abnormal 22.40 12.78 46 58134 167189 90403078
Cardio-respiratory arrest 22.35 12.78 90 58090 63050 90507217
Seizure 22.25 12.78 171 58009 152458 90417809
Hypoalbuminaemia 22.17 12.78 38 58142 15859 90554408
Death 22.15 12.78 187 57993 456364 90113903
Otitis media acute 22.04 12.78 12 58168 1155 90569112
Foetal exposure during pregnancy 21.86 12.78 69 58111 42906 90527361
Bacteriuria 21.67 12.78 12 58168 1194 90569073
Fluid retention 21.66 12.78 15 58165 88076 90482191
Veillonella infection 21.64 12.78 5 58175 33 90570234
Oral mucosal hypertrophy 21.64 12.78 5 58175 33 90570234
Confabulation 21.50 12.78 8 58172 312 90569955
Blood urea increased 21.50 12.78 55 58125 30358 90539909
Agonal respiration 21.40 12.78 7 58173 185 90570082
Vitamin K deficiency 21.24 12.78 9 58171 496 90569771
Gamma-glutamyltransferase increased 21.23 12.78 63 58117 37889 90532378
Mental status changes 21.15 12.78 70 58110 44609 90525658
Blood pressure fluctuation 21.14 12.78 4 58176 52409 90517858
Urine glucose/creatinine ratio increased 21.05 12.78 7 58173 195 90570072
Generalised oedema 20.83 12.78 41 58139 19012 90551255
Eyelid oedema 20.80 12.78 31 58149 11503 90558764
Pancreatitis necrotising 20.79 12.78 15 58165 2366 90567901
Decreased appetite 20.71 12.78 149 58031 376391 90193876
Palpitations 20.62 12.78 35 58145 136693 90433574
Pulseless electrical activity 20.57 12.78 27 58153 8905 90561362
Waterhouse-Friderichsen syndrome 20.40 12.78 4 58176 10 90570257
Nicotine dependence 20.39 12.78 11 58169 1039 90569228
Adverse drug reaction 20.38 12.78 27 58153 116674 90453593
Loss of personal independence in daily activities 20.38 12.78 35 58145 136070 90434197
Bradycardia 20.37 12.78 107 58073 83740 90486527
Postictal psychosis 20.31 12.78 6 58174 112 90570155
Rhinorrhoea 20.30 12.78 111 58069 88205 90482062
Immunisation reaction 20.20 12.78 10 58170 790 90569477
Hyperkalaemia 20.19 12.78 89 58091 64875 90505392
Purpura 20.18 12.78 35 58145 14743 90555524
Haemostasis 20.09 12.78 8 58172 376 90569891
Pulse absent 20.02 12.78 22 58158 6033 90564234
Renal impairment 20.02 12.78 126 58054 105295 90464972
Morganella infection 20.02 12.78 10 58170 806 90569461
Sopor 20.00 12.78 47 58133 24597 90545670
Coombs negative haemolytic anaemia 19.91 12.78 8 58172 385 90569882
Cerebral artery stenosis 19.88 12.78 9 58171 582 90569685
Depressed level of consciousness 19.87 12.78 96 58084 72688 90497579
Hepatitis fulminant 19.84 12.78 18 58162 3927 90566340
Shunt infection 19.78 12.78 6 58174 123 90570144
Hyponatraemia 19.68 12.78 150 58030 133388 90436879
Pulmonary fibrosis 19.68 12.78 24 58156 107479 90462788
Blood pressure increased 19.67 12.78 63 58117 197154 90373113
Coagulopathy 19.54 12.78 45 58135 23244 90547023
Pleural effusion 19.53 12.78 131 58049 111860 90458407
Transverse sinus thrombosis 19.51 12.78 9 58171 608 90569659
Iris transillumination defect 19.43 12.78 6 58174 131 90570136
Blister 19.31 12.78 91 58089 254907 90315360
Therapeutic product effect incomplete 19.30 12.78 62 58118 193834 90376433
Erythema nodosum 19.28 12.78 21 58159 5703 90564564
Clostridial infection 19.20 12.78 19 58161 4617 90565650
Red blood cell sedimentation rate increased 19.10 12.78 15 58165 82580 90487687
Hypoxic-ischaemic encephalopathy 19.09 12.78 19 58161 4649 90565618
Skin test positive 19.09 12.78 10 58170 890 90569377
Mixed liver injury 19.06 12.78 24 58156 7599 90562668
Anti factor V antibody 19.06 12.78 3 58177 0 90570267
Intravascular haemolysis 19.03 12.78 8 58172 432 90569835
Postpartum sepsis 18.98 12.78 4 58176 16 90570251
Hyperthermia 18.96 12.78 28 58152 10307 90559960
Product use in unapproved indication 18.88 12.78 312 57868 335924 90234343
Joint dislocation 18.86 12.78 3 58177 44579 90525688
Hepatitis toxic 18.74 12.78 17 58163 3708 90566559
Anticonvulsant drug level below therapeutic 18.47 12.78 9 58171 687 90569580
Ear pain 18.39 12.78 7 58173 57695 90512572
Idiosyncratic drug reaction 18.38 12.78 10 58170 961 90569306
Acute hepatic failure 18.28 12.78 43 58137 22518 90547749
Influenza like illness 18.19 12.78 15 58165 80596 90489671
Cerebellar syndrome 18.17 12.78 17 58163 3855 90566412
Septic embolus 18.13 12.78 10 58170 987 90569280
Injection site pruritus 18.06 12.78 6 58174 53828 90516439
Foetal growth restriction 18.06 12.78 26 58154 9354 90560913
Myocarditis 17.95 12.78 32 58148 13774 90556493
Pneumonia mycoplasmal 17.90 12.78 10 58170 1012 90569255
Respiratory acidosis 17.87 12.78 24 58156 8095 90562172
Asymptomatic bacteriuria 17.86 12.78 7 58173 315 90569952
Cardiac tamponade 17.83 12.78 20 58160 5612 90564655
Candida test positive 17.74 12.78 10 58170 1029 90569238
Nocardiosis 17.59 12.78 14 58166 2556 90567711
West Nile viral infection 17.59 12.78 8 58172 523 90569744
Acquired haemophilia 17.48 12.78 10 58170 1059 90569208
Dysphemia 17.42 12.78 15 58165 3055 90567212
Fusarium infection 17.37 12.78 10 58170 1072 90569195
Petechiae 17.36 12.78 34 58146 15707 90554560
Nervous system disorder 17.33 12.78 41 58139 21552 90548715
Pulmonary nocardiosis 17.31 12.78 9 58171 789 90569478
Osteomyelitis 17.30 12.78 48 58132 27798 90542469
Multiple sclerosis relapse 17.25 12.78 6 58174 52299 90517968
Hyperlactacidaemia 17.22 12.78 17 58163 4119 90566148
Hyperthyroidism 17.19 12.78 37 58143 18273 90551994
Cerebral haemorrhage 17.16 12.78 55 58125 34467 90535800
Rhinocerebral mucormycosis 17.16 12.78 9 58171 803 90569464
Atelectasis 17.11 12.78 44 58136 24365 90545902
Pneumonia bacterial 17.09 12.78 30 58150 12760 90557507
Normochromic anaemia 17.03 12.78 7 58173 357 90569910
Conjunctival hyperaemia 17.00 12.78 15 58165 3154 90567113
Antibiotic associated colitis 16.98 12.78 3 58177 3 90570264
Unmasking of previously unidentified disease 16.92 12.78 11 58169 1465 90568802
Muscular weakness 16.70 12.78 72 58108 206594 90363673
Tongue oedema 16.64 12.78 19 58161 5435 90564832
Blood phosphorus increased 16.61 12.78 17 58163 4301 90565966
Drug abuse 16.59 12.78 17 58163 82330 90487937
Mucormycosis 16.46 12.78 16 58164 3805 90566462
Therapeutic response decreased 16.46 12.78 20 58160 89709 90480558
Product quality issue 16.41 12.78 16 58164 79309 90490958
Pseudophaeochromocytoma 16.33 12.78 5 58175 106 90570161
Food intolerance 16.18 12.78 16 58164 3886 90566381
Intentional product use issue 16.07 12.78 78 58102 216814 90353453
Myoclonus 16.04 12.78 37 58143 19131 90551136
Cough 16.04 12.78 329 57851 368633 90201634
Vascular device infection 15.92 12.78 28 58152 11924 90558343
Stomatococcal infection 15.86 12.78 5 58175 117 90570150
Inflammation 15.82 12.78 60 58120 178532 90391735
Lymphopenia 15.78 12.78 41 58139 22840 90547427
Post treatment Lyme disease syndrome 15.76 12.78 3 58177 6 90570261
Infantile apnoea 15.76 12.78 10 58170 1277 90568990
Rhabdomyolysis 15.76 12.78 70 58110 51186 90519081
Relapsing fever 15.57 12.78 6 58174 258 90570009
Dysmetria 15.54 12.78 8 58172 687 90569580
Alpha 1 microglobulin increased 15.50 12.78 4 58176 44 90570223
Anoxia 15.46 12.78 6 58174 263 90570004
Stenotrophomonas bacteraemia 15.44 12.78 5 58175 128 90570139
Deafness bilateral 15.43 12.78 11 58169 1702 90568565
Nasal congestion 15.41 12.78 99 58081 83315 90486952
Pneumonia streptococcal 15.38 12.78 12 58168 2129 90568138
X-ray abnormal 15.35 12.78 5 58175 45419 90524848
Foetal death 15.19 12.78 38 58142 20685 90549582
Hypofibrinogenaemia 15.19 12.78 10 58170 1360 90568907
Brain herniation 15.19 12.78 16 58164 4184 90566083
Hypertensive heart disease 15.18 12.78 13 58167 2627 90567640
Ureterolithiasis 15.08 12.78 12 58168 2190 90568077
Toxic shock syndrome 15.05 12.78 9 58171 1035 90569232
Candida endophthalmitis 15.03 12.78 4 58176 50 90570217
Amniotic cavity infection 15.02 12.78 10 58170 1386 90568881
Electrocardiogram T wave abnormal 14.98 12.78 13 58167 2675 90567592
Vaccination complication 14.93 12.78 9 58171 1050 90569217
Candida infection 14.93 12.78 52 58128 34005 90536262
Ventricular dysfunction 14.92 12.78 15 58165 3716 90566551
Flank pain 14.89 12.78 36 58144 19186 90551081
Hypersensitivity 14.87 12.78 204 57976 454473 90115794
Pallor 14.83 12.78 52 58128 34113 90536154
Onychomycosis 14.76 12.78 3 58177 37373 90532894
Cytomegalovirus infection 14.73 12.78 44 58136 26558 90543709
Septic pulmonary embolism 14.69 12.78 5 58175 150 90570117
Euglycaemic diabetic ketoacidosis 14.68 12.78 19 58161 6182 90564085
Base excess 14.68 12.78 4 58176 55 90570212
Disability 14.65 12.78 4 58176 40741 90529526
Chest pain 14.57 12.78 133 58047 319512 90250755
Fibula agenesis 14.55 12.78 4 58176 57 90570210
Anti-platelet antibody positive 14.55 12.78 4 58176 57 90570210
Central nervous system vasculitis 14.55 12.78 9 58171 1100 90569167
Pleural calcification 14.55 12.78 4 58176 57 90570210
Expired product administered 14.53 12.78 20 58160 6902 90563365
Ear infection 14.52 12.78 14 58166 69761 90500506
Spina bifida occulta 14.48 12.78 4 58176 58 90570209
Brain abscess 14.47 12.78 13 58167 2799 90567468
Erysipelas 14.46 12.78 23 58157 9029 90561238
Superior sagittal sinus thrombosis 14.43 12.78 8 58172 798 90569469
Muscle haemorrhage 14.39 12.78 14 58166 3332 90566935
Thrombocytosis 14.36 12.78 20 58160 6981 90563286
Coagulation factor deficiency 14.36 12.78 4 58176 60 90570207
Klebsiella test positive 14.35 12.78 10 58170 1493 90568774
Microangiopathic haemolytic anaemia 14.31 12.78 8 58172 811 90569456
Osteoporosis 14.29 12.78 25 58155 96506 90473761
Red blood cell agglutination 14.23 12.78 3 58177 12 90570255
Hypovolaemic shock 14.15 12.78 20 58160 7074 90563193
Arthritis reactive 14.05 12.78 7 58173 561 90569706
Stress 14.04 12.78 19 58161 81376 90488891
Cerebral aspergillosis 13.97 12.78 7 58173 568 90569699
Withdrawal of life support 13.94 12.78 4 58176 67 90570200
Tracheobronchitis 13.87 12.78 10 58170 1575 90568692
Staphylococcal sepsis 13.84 12.78 23 58157 9360 90560907
Ascites 13.78 12.78 64 58116 47676 90522591
Pneumomediastinum 13.76 12.78 11 58169 2020 90568247
Electroencephalogram abnormal 13.75 12.78 15 58165 4081 90566186
Tongue necrosis 13.68 12.78 4 58176 72 90570195
Appendicitis 13.67 12.78 24 58156 10207 90560060
Tachycardia foetal 13.51 12.78 5 58175 192 90570075
Stridor 13.46 12.78 16 58164 4777 90565490
Orthostatic hypotension 13.45 12.78 5 58175 41822 90528445
Retinitis 13.41 12.78 4 58176 38454 90531813
Arthritis bacterial 13.41 12.78 20 58160 7425 90562842
Vision blurred 13.40 12.78 32 58148 110261 90460006
Meningitis aseptic 13.37 12.78 19 58161 6754 90563513
Ureteric obstruction 13.36 12.78 11 58169 2107 90568160
Secondary immunodeficiency 13.32 12.78 11 58169 2115 90568152
Periorbital oedema 13.31 12.78 19 58161 6780 90563487
Serum ferritin decreased 13.29 12.78 12 58168 2602 90567665
Hyperthermia malignant 13.25 12.78 9 58171 1289 90568978
Leukoencephalopathy 13.24 12.78 16 58164 4857 90565410
Dysbiosis 13.23 12.78 10 58170 1692 90568575
Peri-implantitis 13.19 12.78 4 58176 82 90570185
Splenomegaly 13.16 12.78 27 58153 12897 90557370
Renal artery stenosis 13.09 12.78 11 58169 2166 90568101
Chemotherapeutic drug level increased 13.07 12.78 5 58175 211 90570056
Nephritis 13.06 12.78 13 58167 3182 90567085
Staphylococcus test positive 13.02 12.78 15 58165 4330 90565937
Granulomatous dermatitis 13.02 12.78 5 58175 213 90570054
Lymphadenopathy 12.95 12.78 61 58119 45714 90524553
Foaming at mouth 12.93 12.78 9 58171 1341 90568926
Biliary dilatation 12.91 12.78 12 58168 2699 90567568
Pneumothorax 12.87 12.78 34 58146 19133 90551134
Aortic stenosis 12.84 12.78 18 58162 6318 90563949

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 568.57 12.56 496 66861 41579 42512399
Off label use 350.02 12.56 1949 65408 636386 41917592
Appendicolith 315.60 12.56 220 67137 13236 42540742
Multiple organ dysfunction syndrome 275.48 12.56 525 66832 96510 42457468
Appendicitis 274.19 12.56 241 67116 20372 42533606
Jarisch-Herxheimer reaction 269.50 12.56 84 67273 719 42553259
Postrenal failure 269.18 12.56 78 67279 505 42553473
Pseudocholelithiasis 226.09 12.56 42 67315 3 42553975
Cardiogenic shock 212.98 12.56 272 67085 35368 42518610
Fatigue 211.20 12.56 227 67130 435414 42118564
Rash maculo-papular 181.05 12.56 258 67099 37245 42516733
Ventricular fibrillation 180.13 12.56 230 67127 29893 42524085
Acute generalised exanthematous pustulosis 168.34 12.56 126 67231 8469 42545509
Hepatocellular injury 164.51 12.56 195 67162 23483 42530495
Blood phosphorus increased 153.78 12.56 140 67217 12385 42541593
Death 152.35 12.56 324 67033 470861 42083117
Ascites 146.51 12.56 295 67062 56383 42497595
Acute kidney injury 145.54 12.56 1035 66322 366302 42187676
Myasthenia gravis 144.96 12.56 152 67205 15985 42537993
Eosinophilia 142.39 12.56 215 67142 32684 42521294
Drug-induced liver injury 137.91 12.56 230 67127 38043 42515935
Agranulocytosis 135.26 12.56 202 67155 30410 42523568
Cholestasis 134.04 12.56 209 67148 32670 42521308
Kounis syndrome 131.43 12.56 76 67281 3292 42550686
Stress 128.73 12.56 242 67115 43970 42510008
Dizziness 128.29 12.56 123 67234 249131 42304847
Condition aggravated 126.95 12.56 774 66583 259980 42293998
Factor V inhibition 125.23 12.56 35 67322 195 42553783
Analgesic therapy 121.91 12.56 93 67264 6431 42547547
Toxic epidermal necrolysis 121.75 12.56 179 67178 26571 42527407
Toxic encephalopathy 120.96 12.56 95 67262 6858 42547120
Cholelithiasis 120.67 12.56 166 67191 23180 42530798
Drug abuse 119.67 12.56 13 67344 104758 42449220
Fall 119.20 12.56 117 67240 234403 42319575
Hyperphosphataemia 117.71 12.56 123 67234 12881 42541097
Drug therapy 117.14 12.56 90 67267 6290 42547688
Clostridium test positive 115.21 12.56 84 67273 5421 42548557
Drug ineffective 112.16 12.56 1500 65857 628697 41925281
Anaphylactic reaction 108.68 12.56 221 67136 42522 42511456
Depression 106.36 12.56 23 67334 111340 42442638
Hyponatraemia 101.74 12.56 372 66985 101090 42452888
Anaphylactic shock 100.77 12.56 153 67204 23364 42530614
Sleep disorder therapy 100.56 12.56 85 67272 6809 42547169
Respiratory failure 98.22 12.56 432 66925 127700 42426278
Clostridium difficile colitis 97.85 12.56 143 67214 21109 42532869
Weight increased 97.79 12.56 25 67332 107958 42446020
Hypertransaminasaemia 97.67 12.56 95 67262 9132 42544846
Hypophosphataemia 95.08 12.56 140 67217 20805 42533173
Blood uric acid increased 93.37 12.56 119 67238 15428 42538550
Product dose omission issue 89.32 12.56 68 67289 154297 42399681
Incorrect route of product administration 88.79 12.56 147 67210 24158 42529820
Drug ineffective for unapproved indication 86.18 12.56 211 67146 45952 42508026
Arthralgia 85.34 12.56 120 67237 205118 42348860
Bronchopulmonary aspergillosis 84.08 12.56 127 67230 19302 42534676
Iron deficiency 83.34 12.56 95 67262 10966 42543012
Pyrexia 83.08 12.56 969 66388 393073 42160905
Ureterolithiasis 82.23 12.56 51 67306 2513 42551465
Hepatitis 81.39 12.56 151 67206 27149 42526829
Pathogen resistance 80.67 12.56 95 67262 11355 42542623
Sepsis 80.55 12.56 565 66792 198769 42355209
Abdominal distension 80.48 12.56 273 67084 71462 42482516
Drug hypersensitivity 78.34 12.56 338 67019 99051 42454927
Neuralgia 76.64 12.56 142 67215 25505 42528473
Septic shock 73.97 12.56 314 67043 91358 42462620
Insomnia 73.78 12.56 48 67309 118205 42435773
Diarrhoea 73.46 12.56 428 66929 460421 42093557
Pain 73.42 12.56 175 67182 244673 42309305
Pain in extremity 73.18 12.56 78 67279 150526 42403452
Long QT syndrome 72.41 12.56 51 67306 3116 42550862
Hospitalisation 71.67 12.56 15 67342 74315 42479663
Immune reconstitution inflammatory syndrome 71.20 12.56 84 67273 10059 42543919
Toxicity to various agents 70.92 12.56 161 67196 228975 42325003
Antacid therapy 70.53 12.56 59 67298 4658 42549320
Haemolytic anaemia 69.96 12.56 91 67266 12036 42541942
Transaminases increased 69.74 12.56 158 67199 32727 42521251
Recalled product administered 69.11 12.56 30 67327 695 42553283
Abdominal discomfort 68.94 12.56 17 67340 75238 42478740
Anticoagulant therapy 66.31 12.56 56 67301 4479 42549499
Cerebrovascular accident 65.43 12.56 36 67321 97124 42456854
Joint swelling 65.03 12.56 14 67343 68008 42485970
Haemolysis 64.98 12.56 78 67279 9511 42544467
Activated partial thromboplastin time prolonged 64.66 12.56 101 67256 15802 42538176
Penile abscess 62.75 12.56 19 67338 146 42553832
Anxiety 62.66 12.56 57 67300 118503 42435475
Myocardial infarction 60.48 12.56 64 67293 123945 42430033
Blood glucose increased 59.56 12.56 21 67336 73678 42480300
Clostridium difficile infection 57.38 12.56 117 67240 22542 42531436
Inappropriate schedule of product administration 57.05 12.56 41 67316 95861 42458117
Weight decreased 56.62 12.56 156 67201 207792 42346186
Tubulointerstitial nephritis 56.55 12.56 142 67215 31406 42522572
Electrocardiogram QT prolonged 56.00 12.56 185 67172 47760 42506218
Vitamin K deficiency 55.14 12.56 22 67335 409 42553569
Malaise 54.94 12.56 163 67194 211993 42341985
Muscle spasms 54.93 12.56 34 67323 86010 42467968
Nasopharyngitis 53.89 12.56 33 67324 83963 42470015
Stevens-Johnson syndrome 52.05 12.56 111 67246 22067 42531911
Blood cholesterol increased 51.79 12.56 124 67233 26617 42527361
Alanine aminotransferase increased 49.72 12.56 273 67084 88133 42465845
Disseminated intravascular coagulation 49.13 12.56 116 67241 24678 42529300
Troponin increased 48.95 12.56 99 67258 18963 42535015
Brain abscess 48.92 12.56 46 67311 4238 42549740
Nocardiosis 48.60 12.56 50 67307 5140 42548838
General physical health deterioration 48.33 12.56 406 66951 150840 42403138
Blood calcium increased 48.08 12.56 63 67294 8391 42545587
Hydronephrosis 47.74 12.56 75 67282 11790 42542188
Acute respiratory distress syndrome 47.29 12.56 129 67228 29979 42523999
Candida infection 47.12 12.56 105 67252 21505 42532473
Hepatitis cholestatic 46.51 12.56 67 67290 9757 42544221
Loss of personal independence in daily activities 46.11 12.56 11 67346 49805 42504173
Klebsiella infection 46.11 12.56 72 67285 11260 42542718
Cardiac failure congestive 45.40 12.56 41 67316 85561 42468417
Feeling abnormal 45.34 12.56 27 67330 69759 42484219
Headache 44.91 12.56 210 67147 239159 42314819
Toxic skin eruption 44.81 12.56 79 67278 13651 42540327
Liver function test increased 44.54 12.56 98 67259 19900 42534078
Injection site pain 44.15 12.56 18 67339 57780 42496198
Total lung capacity decreased 44.00 12.56 40 67317 3530 42550448
Liver injury 43.97 12.56 95 67262 19053 42534925
Asthenia 43.95 12.56 262 67095 280531 42273447
Anuria 43.80 12.56 71 67286 11461 42542517
End stage renal disease 43.72 12.56 87 67270 16471 42537507
Malignant neoplasm progression 43.40 12.56 65 67292 108335 42445643
Cardiac disorder 43.00 12.56 12 67345 48920 42505058
Neuropathy peripheral 42.83 12.56 59 67298 101794 42452184
Rash morbilliform 42.53 12.56 42 67315 4111 42549867
Peripheral swelling 42.44 12.56 48 67309 90222 42463756
Dry skin 42.21 12.56 12 67345 48326 42505652
Portal fibrosis 41.98 12.56 17 67340 329 42553649
Therapeutic product effect decreased 41.89 12.56 6 67351 39144 42514834
Ulcer 41.75 12.56 85 67272 16356 42537622
Dehydration 41.11 12.56 103 67254 141664 42412314
Hyper IgE syndrome 40.99 12.56 14 67343 164 42553814
Bronchopulmonary aspergillosis allergic 40.73 12.56 43 67314 4555 42549423
Crystalluria 40.55 12.56 21 67336 729 42553249
Back pain 40.34 12.56 104 67253 141672 42412306
Product use in unapproved indication 40.19 12.56 457 66900 183999 42369979
Suicidal ideation 40.17 12.56 13 67344 48148 42505830
Hepatic cytolysis 40.17 12.56 113 67244 26731 42527247
Congenital hiatus hernia 39.85 12.56 49 67308 6125 42547853
Contusion 39.40 12.56 9 67348 41976 42512002
Prostate cancer 39.14 12.56 11 67346 44632 42509346
Cryptococcal meningoencephalitis 38.72 12.56 14 67343 196 42553782
Cross sensitivity reaction 38.36 12.56 27 67330 1648 42552330
Wrong technique in product usage process 38.33 12.56 10 67347 42625 42511353
Ureteral disorder 38.24 12.56 13 67344 150 42553828
Bacteroides infection 37.94 12.56 32 67325 2555 42551423
Intentional overdose 37.74 12.56 17 67340 51439 42502539
Corynebacterium infection 37.34 12.56 21 67336 862 42553116
Aspartate aminotransferase increased 37.34 12.56 229 67128 76934 42477044
Mucormycosis 37.21 12.56 51 67306 7092 42546886
Gait disturbance 37.10 12.56 61 67296 97939 42456039
Leukocytosis 36.82 12.56 117 67240 29591 42524387
Dry mouth 36.42 12.56 142 67215 39737 42514241
Memory impairment 36.20 12.56 17 67340 50205 42503773
Disseminated cryptococcosis 34.99 12.56 27 67330 1898 42552080
Inflammatory marker increased 34.84 12.56 48 67309 6708 42547270
Balance disorder 34.54 12.56 16 67341 47629 42506349
Blood pressure increased 34.50 12.56 68 67289 101860 42452118
Psoriasis 34.20 12.56 17 67340 48587 42505391
Torsade de pointes 34.13 12.56 54 67303 8540 42545438
Type IV hypersensitivity reaction 33.40 12.56 29 67328 2408 42551570
Arthropathy 32.95 12.56 4 67353 29593 42524385
Choreoathetosis 32.91 12.56 21 67336 1088 42552890
Bacterial pericarditis 32.67 12.56 10 67347 80 42553898
Drug dependence 32.22 12.56 4 67353 29090 42524888
Swelling 31.86 12.56 171 67186 54714 42499264
Chest pain 31.38 12.56 114 67243 139416 42414562
Tachypnoea 31.25 12.56 90 67267 21572 42532406
Alcohol intolerance 30.97 12.56 14 67343 358 42553620
Lung opacity 30.90 12.56 42 67315 5795 42548183
Trichosporon infection 30.69 12.56 19 67338 933 42553045
Electrocardiogram T wave alternans 30.61 12.56 10 67347 101 42553877
Hypoxia 30.60 12.56 202 67155 69584 42484394
Vision blurred 30.58 12.56 24 67333 53675 42500303
Cyanosis 30.51 12.56 71 67286 14960 42539018
Respiratory distress 30.47 12.56 139 67218 41681 42512297
Thrombocytopenia 30.27 12.56 445 66912 189834 42364144
Sphincter of Oddi dysfunction 30.18 12.56 12 67345 221 42553757
Cataract 29.86 12.56 6 67351 30598 42523380
Decreased appetite 29.76 12.56 181 67176 192956 42361022
Abdominal pain 29.74 12.56 444 66913 190027 42363951
Drug resistance 29.70 12.56 120 67237 34128 42519850
Influenza 29.28 12.56 33 67324 62142 42491836
Blood pressure fluctuation 29.08 12.56 4 67353 26904 42527074
Pleuritic pain 28.84 12.56 45 67312 7032 42546946
Erectile dysfunction 28.66 12.56 3 67354 24910 42529068
Incorrect dose administered 28.53 12.56 25 67332 52949 42501029
Blood test abnormal 28.46 12.56 63 67294 12843 42541135
Hepatitis fulminant 28.27 12.56 37 67320 4922 42549056
Hepatitis toxic 28.24 12.56 27 67330 2540 42551438
Syncope 28.20 12.56 73 67284 99333 42454645
Arteriospasm coronary 28.02 12.56 36 67321 4702 42549276
Cheilitis 27.88 12.56 27 67330 2581 42551397
Overdose 27.84 12.56 80 67277 105184 42448794
Encephalitis 27.72 12.56 51 67306 9107 42544871
Hepatomegaly 27.67 12.56 59 67298 11726 42542252
Herpes dermatitis 27.40 12.56 10 67347 144 42553834
Cerebral cyst 27.06 12.56 12 67345 293 42553685
Suicide attempt 27.02 12.56 20 67337 46080 42507898
Aortic stenosis 26.85 12.56 49 67308 8696 42545282
Flank pain 26.62 12.56 45 67312 7518 42546460
Enterobacter infection 26.44 12.56 28 67329 2976 42551002
Palpitations 26.14 12.56 25 67332 50772 42503206
Shock 26.02 12.56 103 67254 29018 42524960
Orthostatic hypotension 25.94 12.56 8 67349 30562 42523416
Dysgeusia 25.54 12.56 11 67346 34178 42519800
Neoplasm malignant 25.50 12.56 3 67354 22740 42531238
Pseudomembranous colitis 25.47 12.56 28 67329 3105 42550873
Janeway lesion 25.22 12.56 6 67351 15 42553963
Myasthenia gravis crisis 25.05 12.56 16 67341 830 42553148
Mixed liver injury 24.91 12.56 33 67324 4441 42549537
Encephalopathy 24.82 12.56 130 67227 41203 42512775
Hepatic enzyme increased 24.80 12.56 140 67217 45644 42508334
Cardiac arrest 24.75 12.56 273 67084 109047 42444931
Hyperferritinaemia 24.58 12.56 14 67343 589 42553389
Contraindicated product administered 24.56 12.56 5 67352 25267 42528711
Coagulopathy 24.52 12.56 84 67273 22078 42531900
Malignant mesenteric neoplasm 24.47 12.56 7 67350 43 42553935
Endocarditis 24.17 12.56 45 67312 8107 42545871
Haemodynamic instability 24.06 12.56 58 67299 12499 42541479
Dry gangrene 24.03 12.56 13 67344 494 42553484
COVID-19 pneumonia 23.99 12.56 82 67275 21531 42532447
Acute respiratory failure 23.88 12.56 123 67234 38735 42515243
Eczema 23.86 12.56 12 67345 34074 42519904
Intracranial pressure increased 23.79 12.56 33 67324 4641 42549337
Crying 23.78 12.56 39 67318 6355 42547623
Urticaria 23.74 12.56 199 67158 73837 42480141
Fungaemia 23.73 12.56 27 67330 3109 42550869
Haemophagocytic lymphohistiocytosis 23.72 12.56 73 67284 18149 42535829
Fixed eruption 23.63 12.56 24 67333 2430 42551548
Hepatitis acute 23.50 12.56 47 67310 8928 42545050
Therapeutic product effect incomplete 23.42 12.56 48 67309 70891 42483087
Procalcitonin increased 23.27 12.56 23 67334 2253 42551725
Basal cell carcinoma 23.15 12.56 4 67353 22729 42531249
Hypoaesthesia 23.05 12.56 49 67308 71414 42482564
Aspergillus infection 23.04 12.56 66 67291 15771 42538207
Autoimmune haemolytic anaemia 23.03 12.56 36 67321 5635 42548343
Musculoskeletal pain 22.95 12.56 12 67345 33328 42520650
Migraine 22.77 12.56 6 67351 25408 42528570
Allergy test positive 22.72 12.56 9 67348 164 42553814
Serum sickness-like reaction 22.71 12.56 10 67347 240 42553738
Alopecia 22.54 12.56 9 67348 29267 42524711
Therapy interrupted 22.48 12.56 4 67353 22246 42531732
Sedation 22.45 12.56 10 67347 30465 42523513
Mobility decreased 22.45 12.56 14 67343 35292 42518686
Flatulence 22.41 12.56 6 67351 25146 42528832
Palmar-plantar erythrodysaesthesia syndrome 22.38 12.56 3 67354 20579 42533399
Neurotoxicity 22.23 12.56 85 67272 23566 42530412
Pleural effusion 22.15 12.56 243 67114 96923 42457055
Dyspepsia 21.69 12.56 20 67337 41332 42512646
Rectal haemorrhage 21.59 12.56 28 67329 49578 42504400
Sleep apnoea syndrome 21.58 12.56 4 67353 21604 42532374
Cryptococcosis 21.56 12.56 26 67331 3185 42550793
Bacterial parotitis 21.24 12.56 6 67351 35 42553943
Procalcitonin abnormal 21.19 12.56 11 67346 384 42553594
Muscle abscess 21.11 12.56 15 67342 929 42553049
Acute hepatic failure 20.93 12.56 67 67290 17006 42536972
Thrombosis 20.84 12.56 182 67175 68329 42485649
Pleocytosis 20.75 12.56 13 67344 652 42553326
Malabsorption from administration site 20.65 12.56 7 67350 80 42553898
Dermatitis bullous 20.62 12.56 43 67314 8413 42545565
Coagulation factor decreased 20.49 12.56 7 67350 82 42553896
Jejunal ulcer perforation 20.49 12.56 7 67350 82 42553896
Vascular purpura 20.36 12.56 21 67336 2165 42551813
Jaundice 20.23 12.56 108 67249 34481 42519497
Disturbance in attention 20.19 12.56 11 67346 29855 42524123
Metastases to stomach 20.12 12.56 7 67350 87 42553891
Escherichia infection 20.10 12.56 51 67306 11345 42542633
Hepatic function abnormal 20.07 12.56 145 67212 51422 42502556
Mycotic endophthalmitis 20.03 12.56 9 67348 227 42553751
Unevaluable event 19.93 12.56 15 67342 34273 42519705
Face oedema 19.92 12.56 57 67300 13609 42540369
Influenza like illness 19.73 12.56 13 67344 31827 42522151
Febrile neutropenia 19.66 12.56 193 67164 185510 42368468
Haematuria traumatic 19.64 12.56 10 67347 335 42553643
Lung abscess 19.62 12.56 25 67332 3238 42550740
Irritability 19.54 12.56 10 67347 28118 42525860
Drug eruption 19.33 12.56 80 67277 22995 42530983
Dyspnoea exertional 19.17 12.56 31 67326 50117 42503861
Neoplasm progression 19.14 12.56 11 67346 28989 42524989
Visual impairment 19.11 12.56 24 67333 43089 42510889
Intervertebral discitis 19.10 12.56 24 67333 3066 42550912
Erythema multiforme 19.03 12.56 46 67311 9931 42544047
Discomfort 19.02 12.56 8 67349 25211 42528767
Oliguria 18.91 12.56 44 67313 9269 42544709
White blood cell count decreased 18.85 12.56 100 67257 110296 42443682
Heart rate decreased 18.77 12.56 18 67339 36514 42517464
Antinuclear antibody negative 18.68 12.56 5 67352 23 42553955
Pulmonary physical examination abnormal 18.68 12.56 5 67352 23 42553955
Disseminated aspergillosis 18.66 12.56 18 67339 1712 42552266
Colitis ulcerative 18.65 12.56 9 67348 26166 42527812
Stenotrophomonas infection 18.62 12.56 26 67331 3678 42550300
Liver transplant failure 18.62 12.56 7 67350 110 42553868
Pneumonia staphylococcal 18.38 12.56 25 67332 3451 42550527
Blood alkaline phosphatase increased 18.37 12.56 103 67254 33494 42520484
Shock haemorrhagic 18.36 12.56 62 67295 16180 42537798
Nasal congestion 18.35 12.56 12 67345 29489 42524489
Hyperlipidaemia 18.34 12.56 75 67282 21441 42532537
Antimicrobial susceptibility test resistant 18.34 12.56 10 67347 386 42553592
Omental necrosis 18.34 12.56 5 67352 25 42553953
Pulmonary embolism 18.32 12.56 278 67079 119334 42434644
Fluid retention 18.17 12.56 14 67343 31605 42522373
Aggression 18.13 12.56 26 67331 44137 42509841
Arthritis 18.04 12.56 24 67333 42041 42511937
Sleep disorder 18.01 12.56 134 67223 47961 42506017
Gastrooesophageal reflux disease 18.00 12.56 27 67330 44996 42508982
Psychotic disorder 18.00 12.56 12 67345 29196 42524782
Blood pressure systolic increased 17.91 12.56 11 67346 27957 42526021
Systemic candida 17.87 12.56 31 67326 5288 42548690
Device related sepsis 17.66 12.56 26 67331 3861 42550117
Injection site erythema 17.65 12.56 5 67352 20190 42533788
Gait inability 17.61 12.56 7 67350 22826 42531152
Muscular weakness 17.61 12.56 70 67287 83428 42470550
Mucosal inflammation 17.52 12.56 32 67325 49342 42504636
Eastern Cooperative Oncology Group performance status 17.44 12.56 5 67352 31 42553947
Antibiotic level below therapeutic 17.43 12.56 6 67351 72 42553906
Infective chondritis 17.43 12.56 4 67353 8 42553970
Brain herniation 17.38 12.56 29 67328 4794 42549184
Haematochezia 17.28 12.56 42 67315 58394 42495584
Strongyloidiasis 17.13 12.56 24 67333 3407 42550571
Intensive care unit acquired weakness 17.10 12.56 15 67342 1263 42552715
Diabetic ketoacidosis 17.02 12.56 7 67350 22360 42531618
Purpura 16.79 12.56 49 67308 11830 42542148
Micturition urgency 16.74 12.56 49 67308 11849 42542129
Peritoneal dialysis 16.73 12.56 11 67346 600 42553378
Red blood cell schistocytes present 16.66 12.56 9 67348 341 42553637
Cholecystitis acute 16.63 12.56 37 67320 7569 42546409
Hyperamylasaemia 16.57 12.56 11 67346 610 42553368
Myalgia 16.42 12.56 87 67270 95993 42457985
Chorioretinitis 16.41 12.56 11 67346 620 42553358
Head injury 16.39 12.56 6 67351 20576 42533402
Abdominal pain upper 16.33 12.56 71 67286 82538 42471440
Ill-defined disorder 16.31 12.56 3 67354 16293 42537685
Renal papillary necrosis 16.25 12.56 7 67350 159 42553819
Subperiosteal abscess 16.22 12.56 6 67351 90 42553888
Vomiting 16.09 12.56 584 66773 289139 42264839
Diabetes mellitus 15.93 12.56 155 67202 59932 42494046
Faeces pale 15.93 12.56 16 67341 1598 42552380
Dermatitis exfoliative generalised 15.85 12.56 31 67326 5793 42548185
Amnesia 15.82 12.56 13 67344 28424 42525554
Splenomegaly 15.80 12.56 61 67296 16986 42536992
Interleukin-2 receptor increased 15.74 12.56 7 67350 172 42553806
Bile duct stone 15.74 12.56 21 67336 2846 42551132
Psoriatic arthropathy 15.74 12.56 10 67347 24957 42529021
Illness 15.69 12.56 10 67347 24920 42529058
Acute febrile neutrophilic dermatosis 15.60 12.56 17 67340 1867 42552111
Cerebral palsy 15.56 12.56 9 67348 390 42553588
Vitamin A deficiency 15.53 12.56 5 67352 48 42553930
Injection site reaction 15.51 12.56 3 67354 15718 42538260
Cholangitis sclerosing 15.46 12.56 17 67340 1885 42552093
Epistaxis 15.41 12.56 54 67303 66772 42487206
Carotid artery insufficiency 15.39 12.56 4 67353 16 42553962
Arterial angioplasty 15.35 12.56 5 67352 50 42553928
Drug effective for unapproved indication 15.33 12.56 33 67324 6600 42547378
Gout 15.33 12.56 86 67271 27969 42526009
Staphylococcal infection 15.32 12.56 107 67250 37536 42516442
Encephalomalacia 15.30 12.56 13 67344 1048 42552930
Hypercreatininaemia 15.18 12.56 10 67347 547 42553431
Epileptic encephalopathy 15.16 12.56 8 67349 289 42553689
Liver disorder 15.15 12.56 111 67246 39533 42514445
Hypofibrinogenaemia 14.99 12.56 17 67340 1950 42552028
Low birth weight baby 14.98 12.56 42 67315 9913 42544065
Chronic obstructive pulmonary disease 14.91 12.56 159 67198 62955 42491023
Sinusitis 14.77 12.56 33 67324 47259 42506719
Arteriosclerosis 14.74 12.56 5 67352 17984 42535994
Oropharyngeal pain 14.69 12.56 28 67329 42482 42511496
Type IIa hyperlipidaemia 14.64 12.56 8 67349 310 42553668
Dyspnoea 14.64 12.56 562 66795 442059 42111919
Obesity 14.53 12.56 4 67353 16455 42537523
Osteonecrosis of jaw 14.43 12.56 6 67351 19043 42534935
Oesophageal injury 14.40 12.56 7 67350 212 42553766
Cardiac ventricular thrombosis 14.32 12.56 16 67341 1806 42552172
Ototoxicity 14.28 12.56 18 67339 2307 42551671
Hallucination 14.27 12.56 45 67312 57462 42496516
Neuroborreliosis 14.24 12.56 5 67352 64 42553914
Stomatitis 14.24 12.56 37 67320 50292 42503686
Morganella infection 14.23 12.56 10 67347 609 42553369
Hyperthermia 14.21 12.56 48 67309 12526 42541452
Gallbladder fistula 14.21 12.56 4 67353 23 42553955
Gamma-glutamyltransferase increased 14.19 12.56 94 67263 32403 42521575
Adverse event 14.19 12.56 10 67347 23630 42530348
Erythema nodosum 14.14 12.56 16 67341 1832 42552146
Medication error 14.13 12.56 19 67338 33135 42520843
Blood creatinine increased 13.99 12.56 248 67109 109755 42444223
Meningitis bacterial 13.97 12.56 14 67343 1395 42552583
Depressed mood 13.89 12.56 10 67347 23374 42530604
Colonic fistula 13.87 12.56 9 67348 480 42553498
Osteomyelitis fungal 13.86 12.56 8 67349 345 42553633
Hypernatraemia 13.82 12.56 41 67316 9991 42543987
Osteoarthritis 13.77 12.56 11 67346 24394 42529584
Intentional product misuse 13.73 12.56 154 67203 61746 42492232
Chondrocalcinosis 13.58 12.56 10 67347 655 42553323
ADAMTS13 activity decreased 13.55 12.56 6 67351 146 42553832
Loss of consciousness 13.45 12.56 88 67269 92266 42461712
Hepatic necrosis 13.40 12.56 23 67334 3890 42550088
Hypercalciuria 13.39 12.56 8 67349 368 42553610
Coagulation factor V level decreased 13.36 12.56 7 67350 249 42553729
Bronchopleural fistula 13.29 12.56 10 67347 677 42553301
Dry eye 13.26 12.56 4 67353 15502 42538476
Intestinal obstruction 13.24 12.56 14 67343 27144 42526834
Meningococcal infection 13.18 12.56 4 67353 31 42553947
Infective spondylitis 13.16 12.56 7 67350 257 42553721
CD4 lymphocytes increased 13.15 12.56 6 67351 157 42553821
Anticoagulant-related nephropathy 13.15 12.56 6 67351 157 42553821
Herpes zoster 13.09 12.56 26 67331 38851 42515127
Accidental exposure to product 13.09 12.56 8 67349 20385 42533593
Drug withdrawal syndrome 13.08 12.56 9 67348 21540 42532438
Calculus urinary 13.08 12.56 15 67342 1742 42552236
Bronchial haemorrhage 13.07 12.56 10 67347 694 42553284
COVID-19 treatment 13.04 12.56 7 67350 262 42553716
Ocular icterus 13.03 12.56 20 67337 3081 42550897
Congenital multiplex arthrogryposis 12.94 12.56 7 67350 266 42553712
Frequent bowel movements 12.92 12.56 9 67348 21398 42532580
Intentional self-injury 12.86 12.56 4 67353 15198 42538780
Cardiac valve abscess 12.86 12.56 4 67353 34 42553944
Cough 12.84 12.56 201 67156 177902 42376076
Cerebellar syndrome 12.83 12.56 19 67338 2836 42551142
Pneumonia bacterial 12.83 12.56 54 67303 15638 42538340
Dementia 12.80 12.56 5 67352 16475 42537503
Administration site reaction 12.73 12.56 5 67352 89 42553889
Adverse drug reaction 12.63 12.56 25 67332 37409 42516569

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 1444.42 11.74 970 118223 81125 110388981
Acute kidney injury 645.19 11.74 1816 117377 633614 109836492
Multiple organ dysfunction syndrome 640.18 11.74 803 118390 150907 110319199
Eosinophilia 601.34 11.74 499 118694 57437 110412669
Pseudocholelithiasis 579.74 11.74 101 119092 10 110470096
Off label use 542.07 11.74 3097 116096 1497088 108973018
Acute generalised exanthematous pustulosis 533.55 11.74 317 118876 21347 110448759
Rash maculo-papular 515.51 11.74 510 118683 73712 110396394
Jarisch-Herxheimer reaction 446.00 11.74 125 119068 1092 110469014
Fatigue 438.18 11.74 401 118792 1215557 109254549
Toxic epidermal necrolysis 433.78 11.74 411 118782 56316 110413790
Appendicolith 421.54 11.74 235 118958 14020 110456086
Clostridium test positive 396.06 11.74 206 118987 10687 110459419
Joint swelling 385.42 11.74 23 119170 442822 110027284
Postrenal failure 371.92 11.74 101 119092 775 110469331
Pain 356.73 11.74 304 118889 954651 109515455
Agranulocytosis 341.98 11.74 376 118817 61384 110408722
Clostridium difficile colitis 338.15 11.74 319 118874 43459 110426647
Appendicitis 332.99 11.74 263 118930 28201 110441905
Cholestasis 321.78 11.74 372 118821 64146 110405960
Arthralgia 309.97 11.74 233 118960 779399 109690707
Cholelithiasis 296.88 11.74 354 118839 63068 110407038
Cardiogenic shock 289.97 11.74 333 118860 57005 110413101
Septic shock 289.58 11.74 569 118624 156959 110313147
Hepatocellular injury 279.81 11.74 308 118885 50334 110419772
Synovitis 279.01 11.74 3 119190 274089 110196017
Arthropathy 276.74 11.74 7 119186 287515 110182591
Alopecia 276.45 11.74 34 119159 364719 110105387
Respiratory failure 274.27 11.74 671 118522 214661 110255445
Rheumatoid arthritis 271.82 11.74 12 119181 299601 110170505
Drug ineffective 266.72 11.74 2650 116543 1517890 108952216
Weight increased 265.74 11.74 63 119130 419581 110050525
Abdominal discomfort 259.73 11.74 54 119139 393804 110076302
Ventricular fibrillation 257.77 11.74 268 118925 41045 110429061
Completed suicide 240.80 11.74 4 119189 242377 110227729
Factor V inhibition 236.44 11.74 60 119133 341 110469765
Sepsis 235.55 11.74 832 118361 326514 110143592
Nasopharyngitis 232.96 11.74 68 119125 394293 110075813
Headache 231.26 11.74 372 118821 882005 109588101
Anaphylactic shock 228.64 11.74 280 118913 51266 110418840
Haemolytic anaemia 224.93 11.74 184 119009 20736 110449370
Therapeutic product effect decreased 220.89 11.74 10 119183 244306 110225800
Peripheral swelling 215.41 11.74 83 119110 403951 110066155
Glossodynia 215.17 11.74 5 119188 221999 110248107
Dizziness 210.89 11.74 266 118927 697927 109772179
Drug ineffective for unapproved indication 209.30 11.74 388 118805 102450 110367656
Blood phosphorus increased 206.36 11.74 158 119035 16182 110453924
Electrocardiogram QT prolonged 205.55 11.74 398 118795 108562 110361544
Systemic lupus erythematosus 204.69 11.74 19 119174 254319 110215787
Pemphigus 203.57 11.74 6 119187 214564 110255542
Stevens-Johnson syndrome 203.55 11.74 252 118941 46649 110423457
Pyrexia 202.51 11.74 1655 117538 896610 109573496
Wound 198.41 11.74 14 119179 234423 110235683
Pain in extremity 197.95 11.74 142 119051 486976 109983130
Toxic encephalopathy 196.29 11.74 149 119044 15065 110455041
Myasthenia gravis 195.97 11.74 172 119021 21339 110448767
Contraindicated product administered 195.97 11.74 20 119173 248247 110221859
Anaphylactic reaction 195.78 11.74 401 118792 113899 110356207
Fall 193.82 11.74 219 118974 603263 109866843
Tubulointerstitial nephritis 189.47 11.74 262 118931 54022 110416084
Ascites 188.66 11.74 350 118843 92458 110377648
Analgesic therapy 185.65 11.74 109 119084 7175 110462931
Hyperphosphataemia 184.40 11.74 148 119045 16233 110453873
Kounis syndrome 178.78 11.74 99 119094 5826 110464280
Chest X-ray abnormal 177.76 11.74 112 119081 8375 110461731
Drug therapy 177.70 11.74 106 119087 7185 110462921
Insomnia 174.83 11.74 85 119108 360505 110109601
Pulmonary function test abnormal 174.46 11.74 92 119101 4908 110465198
Contusion 173.72 11.74 23 119170 233338 110236768
Hepatitis 169.91 11.74 329 118864 89725 110380381
Helicobacter infection 169.26 11.74 6 119187 181871 110288235
Ear pruritus 167.77 11.74 102 119091 7158 110462948
Depression 167.76 11.74 66 119127 317269 110152837
Bronchopulmonary aspergillosis 167.33 11.74 183 119010 29680 110440426
Drug-induced liver injury 164.44 11.74 385 118808 119682 110350424
Malaise 164.07 11.74 296 118897 671523 109798583
Psoriatic arthropathy 162.94 11.74 13 119180 196748 110273358
Clostridium difficile infection 161.91 11.74 238 118955 51891 110418215
Folliculitis 161.59 11.74 4 119189 167649 110302457
Muscle spasms 158.72 11.74 51 119142 278106 110192000
Fibromyalgia 157.79 11.74 6 119187 170903 110299203
Transaminases increased 157.29 11.74 261 118932 63129 110406977
Mobility decreased 155.51 11.74 33 119160 237389 110232717
Type 2 diabetes mellitus 154.66 11.74 9 119184 177223 110292883
Cardiac arrest 153.52 11.74 514 118679 196239 110273867
Blood lactic acid increased 153.21 11.74 131 119062 15690 110454416
Sinusitis 153.09 11.74 64 119129 296624 110173482
Leukocytosis 151.88 11.74 235 118958 53593 110416513
Pericarditis 148.64 11.74 28 119165 219086 110251020
Drug interaction 146.83 11.74 982 118211 499201 109970905
Thrombocytopenia 144.43 11.74 750 118443 348135 110121971
Encephalopathy 144.29 11.74 289 118904 80766 110389340
Ill-defined disorder 143.14 11.74 6 119187 156847 110313259
Discomfort 142.35 11.74 29 119164 214678 110255428
Long QT syndrome 141.77 11.74 91 119102 7027 110463079
Pathogen resistance 140.71 11.74 131 119062 17541 110452565
Hypoaesthesia 140.65 11.74 82 119111 314141 110155965
Sleep disorder therapy 140.18 11.74 92 119101 7379 110462727
Premature delivery 140.06 11.74 169 119024 30463 110439643
Stomatitis 133.57 11.74 62 119131 270180 110199926
Osteoarthritis 133.54 11.74 19 119174 182604 110287502
Blood uric acid increased 133.09 11.74 139 119054 21390 110448716
Acute respiratory distress syndrome 131.94 11.74 219 118974 52979 110417127
Migraine 129.96 11.74 16 119177 171636 110298470
Musculoskeletal pain 129.35 11.74 21 119172 183002 110287104
Breath sounds abnormal 129.17 11.74 148 119045 25256 110444850
Immune reconstitution inflammatory syndrome 128.65 11.74 120 119073 16106 110454000
Status epilepticus 126.45 11.74 163 119030 31408 110438698
Hepatitis cholestatic 124.28 11.74 122 119071 17444 110452662
Product dose omission issue 121.47 11.74 101 119092 321681 110148425
Impaired healing 119.65 11.74 32 119161 196685 110273421
Antacid therapy 118.95 11.74 74 119119 5410 110464696
C-reactive protein abnormal 118.21 11.74 5 119188 129690 110340416
Pseudomembranous colitis 118.21 11.74 78 119115 6313 110463793
Hypoxia 118.02 11.74 357 118836 129158 110340948
Injection site pain 118.01 11.74 24 119169 177898 110292208
Condition aggravated 117.95 11.74 1260 117933 733576 109736530
Hyponatraemia 117.87 11.74 506 118687 217147 110252959
Infusion related reaction 115.11 11.74 145 119048 381017 110089089
Muscle injury 114.65 11.74 10 119183 140797 110329309
Haemolysis 113.23 11.74 110 119083 15529 110454577
Anticoagulant therapy 112.91 11.74 71 119122 5290 110464816
Bursitis 112.13 11.74 7 119186 129911 110340195
Abdominal pain upper 110.51 11.74 128 119065 348983 110121123
Activated partial thromboplastin time prolonged 108.18 11.74 127 119066 22241 110447865
Memory impairment 107.32 11.74 39 119154 196905 110273201
Hypertransaminasaemia 106.32 11.74 131 119062 24124 110445982
Hydronephrosis 106.10 11.74 121 119072 20544 110449562
Drug abuse 105.76 11.74 30 119163 177381 110292725
Dyspepsia 105.45 11.74 37 119156 190928 110279178
Ureterolithiasis 104.69 11.74 63 119130 4339 110465767
Toxic skin eruption 103.89 11.74 138 119055 27377 110442729
Hypophosphataemia 103.76 11.74 152 119041 33030 110437076
Anxiety 103.43 11.74 132 119061 344946 110125160
Platelet count increased 102.41 11.74 134 119059 26200 110443906
Disseminated intravascular coagulation 101.09 11.74 169 119024 41117 110428989
Respiratory distress 98.83 11.74 225 118968 68649 110401457
Road traffic accident 98.35 11.74 4 119189 107394 110362712
Gait disturbance 98.16 11.74 93 119100 278115 110191991
Tachypnoea 96.11 11.74 161 119032 39234 110430872
Drug resistance 94.39 11.74 196 118997 56178 110413928
Lip dry 94.17 11.74 3 119190 100080 110370026
Nasal polyps 92.12 11.74 91 119102 13109 110456997
Hepatic cytolysis 91.70 11.74 191 119002 54862 110415244
Choreoathetosis 91.44 11.74 42 119151 1656 110468450
Weight decreased 91.02 11.74 234 118959 467823 110002283
Klebsiella infection 90.83 11.74 110 119083 19899 110450207
Joint range of motion decreased 90.66 11.74 12 119181 121820 110348286
Rhinitis allergic 90.42 11.74 104 119089 17818 110452288
Shock 88.19 11.74 185 119008 53403 110416703
Haemophagocytic lymphohistiocytosis 87.93 11.74 137 119056 31422 110438684
Rash morbilliform 87.71 11.74 71 119122 7880 110462226
Aspartate aminotransferase increased 87.46 11.74 373 118820 159563 110310543
Psoriasis 86.59 11.74 22 119171 139971 110330135
Alanine aminotransferase increased 85.82 11.74 409 118784 183364 110286742
Injury 85.52 11.74 42 119151 177223 110292883
Gait inability 83.27 11.74 22 119171 136354 110333752
Iron deficiency 82.94 11.74 101 119092 18375 110451731
Injection site reaction 82.64 11.74 3 119190 89067 110381039
Arthritis 81.93 11.74 39 119154 167547 110302559
Upper-airway cough syndrome 81.66 11.74 93 119100 15764 110454342
Pleocytosis 81.58 11.74 39 119154 1685 110468421
Hypertension 81.16 11.74 280 118913 509804 109960302
Encephalitis 79.76 11.74 100 119093 18739 110451367
Sciatica 79.67 11.74 5 119188 92394 110377712
Neutropenia 79.07 11.74 681 118512 373939 110096167
Drug intolerance 76.91 11.74 206 118987 406306 110063800
End stage renal disease 75.45 11.74 104 119089 21369 110448737
Enterococcal infection 75.14 11.74 101 119092 20265 110449841
Neuralgia 74.75 11.74 163 119030 48315 110421791
Nocardiosis 74.56 11.74 63 119130 7423 110462683
Autoimmune haemolytic anaemia 74.03 11.74 73 119120 10494 110459612
Unresponsive to stimuli 74.00 11.74 192 119001 63598 110406508
Anuria 73.94 11.74 110 119083 24231 110445875
Obesity 73.69 11.74 16 119177 113335 110356771
Blood creatinine increased 73.39 11.74 390 118803 182499 110287607
Cross sensitivity reaction 72.87 11.74 55 119138 5512 110464594
Death 72.86 11.74 448 118745 698421 109771685
Torsade de pointes 72.80 11.74 105 119088 22495 110447611
Penile abscess 72.24 11.74 19 119174 127 110469979
Cyanosis 71.82 11.74 121 119072 29620 110440486
Haemodynamic instability 71.78 11.74 105 119088 22783 110447323
Brain abscess 71.59 11.74 59 119134 6715 110463391
Hospitalisation 71.45 11.74 32 119161 142461 110327645
Wound infection 70.59 11.74 10 119183 96455 110373651
Altered state of consciousness 69.48 11.74 176 119017 57450 110412656
Intentional overdose 69.24 11.74 28 119165 132473 110337633
Vasculitis 68.78 11.74 132 119061 35741 110434365
Gastrooesophageal reflux disease 68.48 11.74 56 119137 179920 110290186
Inappropriate schedule of product administration 68.44 11.74 71 119122 203566 110266540
Stress 68.21 11.74 259 118934 105089 110365017
Acute respiratory failure 68.11 11.74 207 118986 75053 110395053
Gastrointestinal disorder 67.96 11.74 97 119096 241855 110228251
Night sweats 67.32 11.74 30 119163 133953 110336153
Grip strength decreased 67.19 11.74 5 119188 80169 110389937
Back pain 67.19 11.74 192 119001 370804 110099302
Vitamin K deficiency 66.50 11.74 28 119165 893 110469213
Troponin increased 66.50 11.74 117 119076 29649 110440457
Dermatitis bullous 66.31 11.74 88 119105 17441 110452665
Injection site erythema 66.09 11.74 11 119182 94165 110375941
Lower limb fracture 65.19 11.74 4 119189 75344 110394762
Product use issue 65.14 11.74 150 119043 311545 110158561
Toxicity to various agents 64.73 11.74 282 118911 480273 109989833
Candida infection 63.58 11.74 152 119041 47857 110422249
Musculoskeletal stiffness 63.16 11.74 129 119064 279693 110190413
Mucormycosis 62.81 11.74 67 119126 10561 110459545
Full blood count abnormal 62.25 11.74 166 119027 55886 110414220
Adverse event 61.94 11.74 20 119173 108789 110361317
Hepatic function abnormal 61.54 11.74 224 118969 89071 110381035
Linear IgA disease 61.11 11.74 45 119148 4344 110465762
Product use in unapproved indication 60.72 11.74 743 118450 446634 110023472
Neurotoxicity 60.67 11.74 138 119055 42069 110428037
Type IV hypersensitivity reaction 60.55 11.74 51 119142 5982 110464124
Loss of personal independence in daily activities 60.48 11.74 44 119149 149976 110320130
Renal failure 59.93 11.74 434 118759 226140 110243966
Myasthenia gravis crisis 59.41 11.74 32 119161 1782 110468324
Lower respiratory tract infection 59.29 11.74 107 119086 242999 110227107
Blood pressure increased 59.26 11.74 118 119075 258255 110211851
Dermatitis exfoliative 59.20 11.74 67 119126 11280 110458826
Balance disorder 58.71 11.74 26 119167 116534 110353572
Feeling abnormal 58.51 11.74 65 119128 180646 110289460
Stenotrophomonas infection 57.73 11.74 49 119144 5809 110464297
Blood calcium increased 56.92 11.74 83 119110 17957 110452149
Congenital hiatus hernia 56.91 11.74 50 119143 6209 110463897
Neck pain 56.67 11.74 31 119162 123099 110347007
Endocarditis 56.65 11.74 71 119122 13300 110456806
Blood pressure fluctuation 56.56 11.74 7 119186 74817 110395289
Jaundice 56.51 11.74 166 119027 59070 110411036
Cataract 56.41 11.74 9 119184 79476 110390630
Crystalluria 56.16 11.74 28 119165 1327 110468779
Enterobacter infection 56.02 11.74 48 119145 5763 110464343
Cholangitis 55.72 11.74 78 119115 16257 110453849
Inflammatory marker increased 55.29 11.74 73 119120 14396 110455710
Asthenia 55.21 11.74 476 118717 688523 109781583
Autoimmune disorder 55.11 11.74 4 119189 65479 110404627
Oliguria 54.79 11.74 83 119110 18574 110451532
Paraesthesia 54.66 11.74 137 119056 276384 110193722
Erythema 54.40 11.74 516 118677 290931 110179175
Dry skin 54.25 11.74 24 119169 107629 110362477
Therapeutic product effect incomplete 54.14 11.74 99 119094 223706 110246400
Pleural effusion 53.86 11.74 352 118841 177357 110292749
Prescribed overdose 53.70 11.74 14 119179 87567 110382539
Palpitations 52.95 11.74 56 119137 159156 110310950
Inflammation 52.76 11.74 79 119114 193159 110276947
Diarrhoea 52.67 11.74 888 118305 1138617 109331489
Aspergillus infection 52.52 11.74 97 119096 25519 110444587
Blood potassium decreased 51.96 11.74 152 119041 53962 110416144
International normalised ratio increased 51.84 11.74 208 118985 86564 110383542
COVID-19 pneumonia 51.80 11.74 120 119073 37023 110433083
Metabolic acidosis 51.73 11.74 229 118964 99515 110370591
Pancytopenia 51.73 11.74 395 118798 209218 110260888
Decreased appetite 51.65 11.74 301 118892 475545 109994561
Swelling 50.98 11.74 200 118993 350841 110119265
Leukopenia 50.88 11.74 304 118889 148487 110321619
Hepatitis fulminant 50.65 11.74 54 119139 8506 110461600
Chest pain 50.58 11.74 221 118972 376154 110093952
Disseminated cryptococcosis 50.53 11.74 33 119160 2624 110467482
Muscular weakness 49.97 11.74 122 119071 248346 110221760
Taste disorder 49.71 11.74 6 119187 65381 110404725
Cholecystitis 49.33 11.74 95 119098 25787 110444319
Drug eruption 48.94 11.74 148 119045 53511 110416595
Bile duct stone 48.87 11.74 46 119147 6243 110463863
Lacrimation increased 48.78 11.74 105 119088 30845 110439261
Incorrect route of product administration 48.71 11.74 166 119027 63895 110406211
Escherichia infection 48.59 11.74 90 119103 23726 110446380
Aortic stenosis 48.54 11.74 65 119128 12994 110457112
Infection 48.47 11.74 213 118980 361987 110108119
Pneumococcal infection 48.42 11.74 28 119165 1791 110468315
Abdominal distension 48.38 11.74 339 118854 174764 110295342
Hip arthroplasty 48.17 11.74 3 119190 55810 110414296
Vanishing bile duct syndrome 47.56 11.74 34 119159 3134 110466972
Hepatitis acute 47.52 11.74 78 119115 18688 110451418
Hepatitis toxic 47.34 11.74 44 119149 5877 110464229
Coagulopathy 47.30 11.74 123 119070 40788 110429318
Suicidal ideation 47.24 11.74 21 119172 93916 110376190
Fixed eruption 47.13 11.74 38 119155 4194 110465912
Staphylococcal infection 46.97 11.74 174 119019 69770 110400336
Sneezing 46.44 11.74 105 119088 31879 110438227
Exposure during pregnancy 46.17 11.74 324 118869 167100 110303006
Visual impairment 46.15 11.74 46 119147 134382 110335724
Acinetobacter infection 46.10 11.74 35 119158 3538 110466568
Trichosporon infection 45.58 11.74 24 119169 1276 110468830
Anaemia 45.40 11.74 835 118358 546251 109923855
Bacteroides infection 45.38 11.74 32 119161 2887 110467219
Dermatitis exfoliative generalised 44.48 11.74 57 119136 10915 110459191
Blepharospasm 44.36 11.74 4 119189 54847 110415259
Total lung capacity decreased 44.09 11.74 46 119147 7068 110463038
Injection site swelling 43.84 11.74 7 119186 61783 110408323
Amnesia 43.69 11.74 30 119163 105378 110364728
Fluid retention 43.03 11.74 24 119169 94283 110375823
Joint stiffness 42.68 11.74 10 119183 67233 110402873
Nausea 42.34 11.74 1012 118181 1234678 109235428
Erythema multiforme 42.14 11.74 79 119114 21018 110449088
Myocardial infarction 42.11 11.74 90 119103 191993 110278113
Tachycardia 41.64 11.74 400 118793 226245 110243861
Intervertebral discitis 41.19 11.74 44 119149 6946 110463160
Corynebacterium infection 40.90 11.74 26 119167 1974 110468132
Cholecystitis acute 40.51 11.74 66 119127 15716 110454390
Lung opacity 40.28 11.74 56 119137 11596 110458510
Wrong technique in product usage process 40.18 11.74 22 119171 87326 110382780
Pulmonary embolism 40.14 11.74 380 118813 214094 110256012
Face oedema 40.11 11.74 102 119091 33367 110436739
Hepatomegaly 40.08 11.74 78 119115 21336 110448770
Hypercreatininaemia 39.84 11.74 22 119171 1287 110468819
Hepatic enzyme increased 39.79 11.74 194 118999 320698 110149408
Symmetrical drug-related intertriginous and flexural exanthema 39.64 11.74 25 119168 1872 110468234
Hypotension 39.51 11.74 788 118405 523061 109947045
Acute hepatic failure 39.48 11.74 107 119086 36361 110433745
Alveolitis 39.44 11.74 35 119158 4404 110465702
Eye pruritus 39.40 11.74 100 119093 32675 110437431
Vision blurred 38.98 11.74 49 119144 128973 110341133
Meningitis bacterial 38.86 11.74 30 119163 3109 110466997
Mixed liver injury 38.73 11.74 56 119137 12023 110458083
Bone erosion 38.55 11.74 3 119190 46368 110423738
Blood pressure systolic increased 38.04 11.74 21 119172 82970 110387136
Influenza B virus test positive 37.83 11.74 15 119178 409 110469697
Renal tubular necrosis 37.70 11.74 94 119099 30381 110439725
Purpura 37.59 11.74 82 119111 24306 110445800
Gamma-glutamyltransferase increased 37.45 11.74 148 119045 61161 110408945
Frequent bowel movements 37.44 11.74 15 119178 71375 110398731
Blister 37.34 11.74 123 119070 227253 110242853
Urticaria 37.11 11.74 515 118678 318342 110151764
Alcohol intolerance 37.06 11.74 15 119178 432 110469674
Renal papillary necrosis 36.99 11.74 15 119178 434 110469672
Orthostatic hypotension 36.27 11.74 13 119180 66236 110403870
CSF oligoclonal band present 36.27 11.74 15 119178 457 110469649
Cryptococcosis 36.23 11.74 34 119159 4597 110465509
Nosocomial infection 36.21 11.74 29 119164 3170 110466936
Bronchopulmonary aspergillosis allergic 36.11 11.74 45 119148 8381 110461725
Hypokalaemia 36.02 11.74 327 118866 182121 110287985
Bronchopleural fistula 35.68 11.74 18 119175 875 110469231
Hyperthermia 35.65 11.74 74 119119 21198 110448908
Red blood cell sedimentation rate increased 35.62 11.74 20 119173 78282 110391824
Hypofibrinogenaemia 35.57 11.74 26 119167 2481 110467625
Influenza like illness 35.54 11.74 26 119167 88386 110381720
Cryptococcal meningoencephalitis 35.50 11.74 14 119179 376 110469730
Cerebrovascular accident 34.90 11.74 91 119102 181193 110288913
Flank pain 34.78 11.74 77 119116 23053 110447053
Neutrophilia 34.75 11.74 49 119144 10280 110459826
Gout 34.42 11.74 102 119091 36464 110433642
Cholestatic liver injury 34.21 11.74 41 119152 7335 110462771
Angioedema 34.15 11.74 202 118991 98298 110371808
Procalcitonin increased 34.10 11.74 31 119162 4025 110466081
Systemic inflammatory response syndrome 34.09 11.74 55 119138 12988 110457118
Partial seizures 34.06 11.74 51 119142 11298 110458808
Intracranial pressure increased 34.01 11.74 49 119144 10486 110459620
Splenomegaly 33.99 11.74 79 119114 24419 110445687
Bacterial pericarditis 33.94 11.74 10 119183 106 110470000
CSF measles antibody positive 33.86 11.74 9 119184 63 110470043
Rash erythematous 33.83 11.74 176 119017 81656 110388450
Fungaemia 33.57 11.74 37 119156 6049 110464057
Portal fibrosis 33.52 11.74 16 119177 689 110469417
Morganella infection 33.48 11.74 20 119173 1359 110468747
Rubella antibody positive 33.38 11.74 9 119184 67 110470039
Hepatosplenomegaly 32.98 11.74 39 119154 6880 110463226
Sulphaemoglobinaemia 32.93 11.74 15 119178 580 110469526
Brain herniation 32.76 11.74 44 119149 8819 110461287
Sleep disorder due to a general medical condition 32.59 11.74 8 119185 52104 110418002
Pneumonia bacterial 32.48 11.74 81 119112 26180 110443926
Influenza 32.46 11.74 85 119108 169016 110301090
Renal impairment 32.38 11.74 328 118865 188117 110281989
Lung abscess 32.13 11.74 33 119160 4979 110465127
Oropharyngeal pain 31.68 11.74 61 119132 135215 110334891
Cardiac failure congestive 31.25 11.74 73 119120 150927 110319179
Electrocardiogram T wave alternans 31.22 11.74 10 119183 143 110469963
Blood test abnormal 31.13 11.74 84 119109 28470 110441636
Pancreatitis acute 30.96 11.74 138 119055 60136 110409970
Erythema nodosum 30.89 11.74 37 119156 6616 110463490
Blood glucose increased 30.81 11.74 60 119133 132436 110337670
Agonal respiration 30.79 11.74 12 119181 312 110469794
Product quality issue 30.73 11.74 23 119170 77276 110392830
Onychomycosis 30.65 11.74 3 119190 38528 110431578
Prescribed underdose 30.59 11.74 16 119177 65158 110404948
Suicide attempt 30.48 11.74 40 119153 103354 110366752
Strongyloidiasis 30.47 11.74 32 119161 4954 110465152
Propofol infusion syndrome 30.44 11.74 24 119169 2565 110467541
Type I hypersensitivity 30.42 11.74 36 119157 6357 110463749
Lupus-like syndrome 30.38 11.74 4 119189 40788 110429318
Blood alkaline phosphatase increased 30.32 11.74 154 119039 70781 110399325
Hyperbilirubinaemia 30.26 11.74 87 119106 30584 110439522
Basal cell carcinoma 30.23 11.74 6 119187 45264 110424842
Systemic candida 30.18 11.74 45 119148 9929 110460177
Nephropathy toxic 30.12 11.74 81 119112 27397 110442709
Sedation 30.00 11.74 19 119174 69664 110400442
Organic brain syndrome 29.99 11.74 14 119179 573 110469533
Sphincter of Oddi dysfunction 29.97 11.74 14 119179 574 110469532
Ear pain 29.91 11.74 10 119183 53216 110416890
Ureteral disorder 29.85 11.74 14 119179 579 110469527
Muscle abscess 29.80 11.74 19 119174 1450 110468656
Mitochondrial DNA mutation 29.53 11.74 13 119180 463 110469643
Multiple-drug resistance 29.53 11.74 52 119141 13183 110456923
Weber tuning fork test abnormal 29.39 11.74 9 119184 110 110469996
Pyelonephritis 29.28 11.74 76 119117 25174 110444932
Multiple sclerosis relapse 29.01 11.74 9 119184 50231 110419875
Herpes zoster 28.91 11.74 45 119148 108334 110361772
Pneumonia necrotising 28.86 11.74 20 119173 1755 110468351
Accidental exposure to product 28.80 11.74 9 119184 49999 110420107
Neuropathy peripheral 28.73 11.74 98 119095 179179 110290927
Generalised bullous fixed drug eruption 28.64 11.74 15 119178 789 110469317
Hyperpyrexia 28.22 11.74 39 119154 8030 110462076
Injection site pruritus 28.16 11.74 10 119183 51248 110418858
Procalcitonin abnormal 28.09 11.74 12 119181 397 110469709
Bacteraemia 28.08 11.74 105 119088 42285 110427821
Thrombosis 28.05 11.74 207 118986 108455 110361651
Hyper IgE syndrome 28.01 11.74 14 119179 667 110469439
Pregnancy 27.99 11.74 10 119183 51057 110419049
Sleep apnoea syndrome 27.77 11.74 5 119188 40442 110429664
Pulseless electrical activity 27.74 11.74 58 119135 16699 110453407
Eosinophilic pneumonia acute 27.63 11.74 19 119174 1646 110468460
Dysgeusia 27.59 11.74 21 119172 69964 110400142
Empyema 27.56 11.74 32 119161 5538 110464568
Hypernatraemia 27.53 11.74 60 119133 17773 110452333
Janeway lesion 27.50 11.74 6 119187 15 110470091
Eastern Cooperative Oncology Group performance status 27.40 11.74 9 119184 140 110469966
Hepatitis infectious mononucleosis 27.39 11.74 10 119183 216 110469890
Neoplasm progression 27.28 11.74 18 119175 64577 110405529
Rectal haemorrhage 27.23 11.74 55 119138 119778 110350328
Chronic obstructive pulmonary disease 27.08 11.74 206 118987 108952 110361154
Disseminated aspergillosis 27.05 11.74 22 119171 2458 110467648
Peritoneal dialysis 26.99 11.74 15 119178 889 110469217
Encephalomalacia 26.98 11.74 18 119175 1484 110468622
Eosinophilic pneumonia 26.90 11.74 36 119157 7191 110462915
Pneumonia mycoplasmal 26.86 11.74 19 119174 1722 110468384
Coagulation factor decreased 26.69 11.74 11 119182 332 110469774
COVID-19 treatment 26.66 11.74 12 119181 451 110469655
Nervousness 26.54 11.74 4 119189 36847 110433259
Blood gases abnormal 26.15 11.74 17 119176 1341 110468765
Illness 26.10 11.74 30 119163 82141 110387965
Serum sickness-like reaction 26.08 11.74 14 119179 774 110469332
Cerebellar syndrome 25.96 11.74 33 119160 6269 110463837
Hypovolaemic shock 25.94 11.74 52 119141 14531 110455575
Cerebral cyst 25.92 11.74 12 119181 482 110469624
Haematuria traumatic 25.75 11.74 11 119182 364 110469742
Cheilitis 25.70 11.74 33 119160 6332 110463774
Hypertriglyceridaemia 25.68 11.74 55 119138 16099 110454007
Pyuria 25.68 11.74 22 119171 2641 110467465
Treatment failure 25.65 11.74 184 119009 277050 110193056
Malignant mesenteric neoplasm 25.63 11.74 7 119186 55 110470051
SJS-TEN overlap 25.61 11.74 19 119174 1855 110468251
Chorioretinitis 25.52 11.74 17 119176 1398 110468708
Osteoporosis 25.40 11.74 34 119159 87118 110382988
Osteomyelitis 25.37 11.74 92 119101 36508 110433598
Immune thrombocytopenia 25.36 11.74 67 119126 22427 110447679
Procedural pain 25.30 11.74 4 119189 35561 110434545
Cholangitis acute 25.26 11.74 19 119174 1894 110468212
Pneumonia staphylococcal 25.26 11.74 32 119161 6059 110464047
Granulomatous dermatitis 25.20 11.74 12 119181 514 110469592
Fibrin D dimer increased 25.03 11.74 41 119152 9804 110460302
Intentional self-injury 24.91 11.74 5 119188 37424 110432682
Muscle tension dysphonia 24.90 11.74 10 119183 282 110469824
Hip fracture 24.90 11.74 4 119189 35147 110434959
Pulmonary fibrosis 24.79 11.74 45 119148 101997 110368109
Hyperlipidaemia 24.75 11.74 90 119103 35758 110434348
No adverse event 24.68 11.74 150 119043 73689 110396417
Ureteric obstruction 24.63 11.74 23 119170 3091 110467015
Surgery 24.55 11.74 7 119186 41276 110428830
Ear infection 24.51 11.74 19 119174 62713 110407393
Vascular purpura 24.48 11.74 25 119168 3746 110466360
Hyperferritinaemia 24.47 11.74 15 119178 1068 110469038
Urinary tract infection fungal 24.42 11.74 16 119177 1279 110468827
Calculus urinary 24.39 11.74 23 119170 3129 110466977
Adverse drug reaction 24.37 11.74 48 119145 105511 110364595
Rash pustular 24.34 11.74 47 119146 12782 110457324
Dry eye 24.31 11.74 15 119178 55778 110414328
Agitation 24.05 11.74 206 118987 112845 110357261
Blood brain barrier defect 24.05 11.74 9 119184 209 110469897
Lip oedema 24.02 11.74 35 119158 7565 110462541
Encephalitis autoimmune 24.02 11.74 24 119169 3504 110466602
Joint dislocation 23.97 11.74 4 119189 34186 110435920
Intensive care unit acquired weakness 23.80 11.74 20 119173 2339 110467767
Interleukin-2 receptor increased 23.66 11.74 10 119183 322 110469784
X-ray abnormal 23.55 11.74 6 119187 38111 110431995
Drug effective for unapproved indication 23.41 11.74 49 119144 14118 110455988
Waterhouse-Friderichsen syndrome 23.37 11.74 5 119188 11 110470095
Rhabdomyolysis 23.35 11.74 215 118978 120186 110349920
Eye irritation 23.26 11.74 4 119189 33448 110436658
Pneumothorax 23.04 11.74 87 119106 35198 110434908
Depressed mood 23.02 11.74 19 119174 60790 110409316
Bone marrow failure 22.94 11.74 123 119070 57725 110412381
Herpes dermatitis 22.88 11.74 10 119183 350 110469756
Shock haemorrhagic 22.85 11.74 73 119120 27174 110442932
Lymphadenopathy 22.83 11.74 132 119061 63703 110406403
Colitis ulcerative 22.73 11.74 30 119163 77333 110392773
Bacterial parotitis 22.70 11.74 6 119187 41 110470065
Factor V deficiency 22.60 11.74 7 119186 89 110470017
Sinus disorder 22.57 11.74 4 119189 32724 110437382
Disability 22.42 11.74 3 119190 30220 110439886
Ulcer 22.36 11.74 99 119094 43017 110427089
Diabetes mellitus 22.15 11.74 183 119010 99198 110370908
Toxic shock syndrome 22.10 11.74 16 119177 1504 110468602
Pulmonary nocardiosis 21.92 11.74 20 119173 2609 110467497
Acquired haemophilia 21.91 11.74 20 119173 2611 110467495
Petechiae 21.91 11.74 65 119128 23252 110446854
Megacolon 21.75 11.74 25 119168 4280 110465826
Tooth disorder 21.73 11.74 3 119190 29506 110440600
Myopathy toxic 21.71 11.74 15 119178 1310 110468796
West Nile viral infection 21.69 11.74 15 119178 1311 110468795
Pelvic inflammatory disease 21.55 11.74 16 119177 1564 110468542
Otitis media acute 21.53 11.74 16 119177 1566 110468540
Allergy test positive 21.41 11.74 13 119180 910 110469196
Haemodialysis 21.23 11.74 54 119139 17665 110452441
Macule 21.22 11.74 23 119170 3690 110466416
Gastric disorder 21.09 11.74 5 119188 33352 110436754
Hypoalbuminaemia 21.08 11.74 74 119119 28900 110441206
Device related sepsis 21.03 11.74 33 119160 7614 110462492
Dyspnoea exertional 20.98 11.74 51 119142 104009 110366097
Coombs negative haemolytic anaemia 20.92 11.74 11 119182 583 110469523
Jejunal ulcer perforation 20.73 11.74 7 119186 119 110469987
Hepatic failure 20.71 11.74 136 119057 68603 110401503
Leukaemoid reaction 20.66 11.74 10 119183 444 110469662
Pulmonary physical examination abnormal 20.58 11.74 5 119188 23 110470083
Heart rate decreased 20.54 11.74 36 119157 82720 110387386
Therapeutic response decreased 20.49 11.74 46 119147 96453 110373653
Hyperamylasaemia 20.42 11.74 14 119179 1207 110468899
Haemoperitoneum 20.30 11.74 27 119166 5361 110464745
Benign prostatic hyperplasia 20.24 11.74 54 119139 18180 110451926
CSF protein increased 20.11 11.74 15 119178 1476 110468630
Bronchospasm 20.11 11.74 75 119118 30164 110439942
Cardiac disorder 20.03 11.74 32 119161 76248 110393858
Intentional product use issue 19.91 11.74 171 119022 247735 110222371
Hallucination, visual 19.83 11.74 90 119103 39515 110430591
Drug dependence 19.73 11.74 15 119178 50005 110420101
Blood pressure diastolic decreased 19.72 11.74 7 119186 35878 110434228
Oedema 19.59 11.74 139 119054 209837 110260269
Abdominal pain 19.57 11.74 706 118487 512283 109957823
Gastroenteritis clostridial 19.56 11.74 13 119180 1065 110469041
Head injury 19.54 11.74 11 119182 43006 110427100
Hypersensitivity 19.49 11.74 312 118881 403686 110066420
Overdose 19.35 11.74 160 119033 233634 110236472
Underdose 19.34 11.74 24 119169 63530 110406576
Arteriospasm coronary 19.34 11.74 35 119158 9065 110461041
Liver function test increased 19.18 11.74 162 119031 88386 110381720
Hypersensitivity vasculitis 19.16 11.74 30 119163 6907 110463199
Malignant neoplasm progression 19.13 11.74 110 119083 174457 110295649
Liver transplant failure 19.10 11.74 7 119186 153 110469953
Hyperlactacidaemia 19.07 11.74 33 119160 8253 110461853
Laryngeal mass 19.05 11.74 6 119187 81 110470025
Bacterial infection 19.02 11.74 99 119094 45937 110424169
Hot flush 19.00 11.74 26 119167 66010 110404096
Sputum purulent 18.96 11.74 16 119177 1882 110468224
Oral mucosal hypertrophy 18.94 11.74 5 119188 34 110470072
Injection site haemorrhage 18.92 11.74 6 119187 33022 110437084
Meningitis 18.78 11.74 40 119153 11662 110458444
Pneumococcal sepsis 18.78 11.74 17 119176 2195 110467911
Haemostasis 18.75 11.74 10 119183 546 110469560
Laryngeal stenosis 18.72 11.74 14 119179 1384 110468722
Malabsorption from administration site 18.68 11.74 7 119186 163 110469943
Anticonvulsant drug level below therapeutic 18.67 11.74 13 119180 1149 110468957
Antibiotic associated colitis 18.63 11.74 4 119189 9 110470097
Unmasking of previously unidentified disease 18.59 11.74 19 119174 2849 110467257
Incorrect dose administered 18.47 11.74 54 119139 103587 110366519
Antibiotic level below therapeutic 18.47 11.74 6 119187 90 110470016
Vascular device infection 18.43 11.74 49 119144 16463 110453643
Postpartum sepsis 18.34 11.74 4 119189 10 110470096
Therapy interrupted 18.33 11.74 16 119177 49806 110420300
Pyelonephritis acute 18.29 11.74 30 119163 7183 110462923
Heparin-induced thrombocytopenia 18.28 11.74 39 119154 11385 110458721
Meningism 18.27 11.74 11 119182 758 110469348
Skin test positive 18.27 11.74 14 119179 1435 110468671
Omental necrosis 18.23 11.74 5 119188 40 110470066
Neuroborreliosis 18.18 11.74 7 119186 176 110469930
Localised infection 18.17 11.74 12 119181 43036 110427070
Erythrodermic psoriasis 18.16 11.74 16 119177 1994 110468112
Pleuritic pain 18.12 11.74 48 119145 16092 110454014
Feeling hot 18.09 11.74 45 119148 91061 110379045
Septic embolus 18.05 11.74 17 119176 2309 110467797
Hypercholesterolaemia 17.94 11.74 45 119148 90792 110379314
Palmar-plantar erythrodysaesthesia syndrome 17.92 11.74 11 119182 41014 110429092
Foot fracture 17.89 11.74 3 119190 25543 110444563
Ocular icterus 17.88 11.74 27 119166 6026 110464080
Mycotic endophthalmitis 17.85 11.74 9 119184 437 110469669
Hypothyroidism 17.84 11.74 32 119161 72867 110397239
Drug hypersensitivity 17.82 11.74 627 118566 453463 110016643
Bronchitis 17.72 11.74 98 119095 156934 110313172
Tracheobronchitis 17.62 11.74 18 119175 2698 110467408
Veillonella infection 17.61 11.74 5 119188 46 110470060
Endocarditis bacterial 17.59 11.74 15 119178 1790 110468316
Relapsing fever 17.44 11.74 9 119184 459 110469647
Pulse absent 17.44 11.74 38 119155 11254 110458852
Eye pain 17.36 11.74 17 119176 50082 110420024
Iris transillumination defect 17.35 11.74 7 119186 200 110469906
Micturition urgency 17.34 11.74 53 119140 19267 110450839
Arterial angioplasty 17.23 11.74 5 119188 50 110470056
Pneumonia streptococcal 17.19 11.74 20 119173 3469 110466637
Cardiac ventricular thrombosis 17.13 11.74 19 119174 3128 110466978
Pain in jaw 17.01 11.74 18 119175 51159 110418947
Carotid artery insufficiency 16.92 11.74 4 119189 16 110470090
Pneumonia cryptococcal 16.77 11.74 17 119176 2525 110467581
Encephalitis brain stem 16.77 11.74 8 119185 344 110469762
Seizure 16.73 11.74 333 118860 220852 110249254
Type IIa hyperlipidaemia 16.68 11.74 9 119184 503 110469603
Central nervous system vasculitis 16.64 11.74 14 119179 1640 110468466
Muscle spasticity 16.58 11.74 9 119184 35906 110434200
Dysmetria 16.51 11.74 13 119180 1386 110468720
Mucosal inflammation 16.48 11.74 51 119142 96090 110374016
Henoch-Schonlein purpura 16.43 11.74 20 119173 3637 110466469
Guillain-Barre syndrome 16.42 11.74 36 119157 10708 110459398
Hypocoagulable state 16.37 11.74 17 119176 2598 110467508
Impaired quality of life 16.25 11.74 6 119187 30011 110440095
Brain death 16.21 11.74 27 119166 6546 110463560
Bacteriuria 16.20 11.74 13 119180 1425 110468681
Sphingomonas paucimobilis infection 16.17 11.74 6 119187 136 110469970
Ototoxicity 16.03 11.74 21 119172 4110 110465996
Hepatic necrosis 16.02 11.74 34 119159 9888 110460218
Body temperature decreased 16.00 11.74 10 119183 36925 110433181
Cell death 15.93 11.74 25 119168 5766 110464340
Pneumonia pneumococcal 15.89 11.74 23 119170 4942 110465164
Injection site rash 15.85 11.74 3 119190 23416 110446690
Infective aneurysm 15.78 11.74 13 119180 1479 110468627
Bronchial obstruction 15.76 11.74 18 119175 3061 110467045
Priapism 15.71 11.74 25 119168 5836 110464270
Clostridial infection 15.69 11.74 26 119167 6276 110463830
Tubulointerstitial nephritis and uveitis syndrome 15.69 11.74 8 119185 398 110469708
Thunderclap headache 15.66 11.74 9 119184 569 110469537
Rhinocerebral mucormycosis 15.59 11.74 13 119180 1504 110468602
Electrolyte imbalance 15.55 11.74 80 119113 36948 110433158
Flatulence 15.55 11.74 20 119173 52129 110417977
Urine output decreased 15.54 11.74 52 119141 19824 110450282
Pancreatitis necrotising 15.49 11.74 24 119169 5477 110464629
Liver abscess 15.48 11.74 29 119164 7710 110462396
Idiosyncratic drug reaction 15.45 11.74 13 119180 1523 110468583
Blood lactate dehydrogenase increased 15.41 11.74 91 119102 44243 110425863
Chronic sinusitis 15.39 11.74 4 119189 25080 110445026
Walking aid user 15.39 11.74 4 119189 25071 110445035
Osteomyelitis fungal 15.34 11.74 8 119185 417 110469689
Panic attack 15.30 11.74 6 119187 28934 110441172
Gallbladder fistula 15.30 11.74 4 119189 26 110470080
Mental status changes 15.30 11.74 137 119056 75985 110394121
Immunisation reaction 15.27 11.74 10 119183 799 110469307
Wound haemorrhage 15.24 11.74 22 119171 4716 110465390
Prostate cancer 15.22 11.74 11 119182 37630 110432476
Expired product administered 15.20 11.74 30 119163 8290 110461816
Shunt infection 15.19 11.74 7 119186 278 110469828
Antimicrobial susceptibility test resistant 15.18 11.74 8 119185 426 110469680
Lymphocyte transformation test positive 15.17 11.74 4 119189 27 110470079
Pulmonary necrosis 15.10 11.74 9 119184 609 110469497
Oral pain 15.06 11.74 11 119182 37433 110432673
Infective chondritis 15.05 11.74 4 119189 28 110470078
Diabetes insipidus 14.90 11.74 26 119167 6544 110463562
Immunodeficiency 14.87 11.74 12 119181 38826 110431280
Hyperkalaemia 14.84 11.74 217 118976 135579 110334527
Endotracheal intubation 14.84 11.74 25 119168 6119 110463987
Abdominal wall haematoma 14.83 11.74 24 119169 5681 110464425
Acne 14.62 11.74 9 119184 33511 110436595
Oesophageal injury 14.57 11.74 7 119186 306 110469800
Acute febrile neutrophilic dermatosis 14.55 11.74 22 119171 4914 110465192
Metastases to stomach 14.54 11.74 7 119186 307 110469799
Hypercapnia 14.42 11.74 35 119158 11124 110458982
Lymphopenia 14.32 11.74 83 119110 40087 110430019
Confusional state 14.31 11.74 390 118803 468290 110001816
Skin lesion 14.27 11.74 100 119093 51531 110418575
Acidosis 14.25 11.74 55 119138 22476 110447630
Cerebral artery stenosis 14.23 11.74 10 119183 897 110469209
Amniotic cavity infection 14.23 11.74 10 119183 897 110469209
Pneumomediastinum 14.22 11.74 22 119171 5014 110465092
Post treatment Lyme disease syndrome 14.21 11.74 3 119190 6 110470100
Localised oedema 14.20 11.74 31 119162 9192 110460914
Gene mutation 14.19 11.74 18 119175 3411 110466695
Electrocardiogram T wave abnormal 14.18 11.74 20 119173 4197 110465909
Bradycardia 14.15 11.74 241 118952 155276 110314830
Multiple sclerosis 14.14 11.74 5 119188 25693 110444413
Eczema 14.13 11.74 36 119157 72257 110397849
Central nervous system infection 14.10 11.74 13 119180 1719 110468387
Glycosylated haemoglobin increased 14.06 11.74 4 119189 23615 110446491
Arthritis bacterial 14.05 11.74 34 119159 10786 110459320
Toothache 14.02 11.74 4 119189 23571 110446535
Staphylococcus test positive 13.98 11.74 27 119166 7343 110462763
Blood fibrinogen increased 13.96 11.74 14 119179 2054 110468052
Nodule 13.91 11.74 9 119184 32622 110437484
Normocytic anaemia 13.90 11.74 25 119168 6442 110463664
Histoplasmosis disseminated 13.87 11.74 19 119174 3880 110466226
Anticoagulant-related nephropathy 13.86 11.74 6 119187 205 110469901
Eating disorder 13.86 11.74 8 119185 30850 110439256
Myalgia 13.86 11.74 163 119030 222218 110247888
Stress cardiomyopathy 13.85 11.74 43 119150 15763 110454343
Confabulation 13.81 11.74 8 119185 513 110469593
PO2 decreased 13.79 11.74 17 119176 3131 110466975
Blood urea increased 13.79 11.74 104 119089 54853 110415253
Candida endophthalmitis 13.78 11.74 6 119187 208 110469898
Respiratory tract infection 13.74 11.74 36 119157 71581 110398525
Psychotic disorder 13.72 11.74 21 119172 50916 110419190
Embolia cutis medicamentosa 13.69 11.74 10 119183 953 110469153
Haemorrhoids 13.69 11.74 11 119182 35661 110434445
Urethral haemorrhage 13.67 11.74 8 119185 523 110469583
Retinitis 13.66 11.74 9 119184 32318 110437788
Haematotoxicity 13.65 11.74 3 119190 21079 110449027
Haematochezia 13.64 11.74 71 119122 115453 110354653
Maternal exposure timing unspecified 13.59 11.74 3 119190 21010 110449096
Anticonvulsant drug level decreased 13.58 11.74 14 119179 2122 110467984
Cholangitis sclerosing 13.57 11.74 18 119175 3564 110466542
Purpura fulminans 13.55 11.74 7 119186 358 110469748
Coronavirus infection 13.48 11.74 31 119162 9514 110460592
Colonic fistula 13.46 11.74 9 119184 745 110469361
Skin discolouration 13.43 11.74 20 119173 49026 110421080
Prothrombin time prolonged 13.36 11.74 45 119148 17216 110452890
Red blood cell schistocytes present 13.27 11.74 9 119184 762 110469344
Transverse sinus thrombosis 13.20 11.74 9 119184 769 110469337
Syncope 13.19 11.74 147 119046 202389 110267717
Dementia 13.14 11.74 9 119184 31664 110438442
Ischaemic limb pain 13.13 11.74 4 119189 48 110470058
Oral pruritus 13.07 11.74 17 119176 3303 110466803
Bone pain 13.07 11.74 32 119161 65101 110405005
Antibiotic level above therapeutic 13.07 11.74 10 119183 1023 110469083
Poisoning deliberate 13.06 11.74 6 119187 26325 110443781
Prothrombin time ratio decreased 13.06 11.74 12 119181 1580 110468526
Tongue oedema 13.00 11.74 28 119165 8228 110461878
Pseudomonas infection 12.99 11.74 62 119131 27791 110442315
Alpha 1 microglobulin increased 12.98 11.74 4 119189 50 110470056
Fungal peritonitis 12.89 11.74 11 119182 1314 110468792
Aspiration 12.84 11.74 66 119127 30467 110439639
Nicotine dependence 12.84 11.74 11 119182 1320 110468786
Adverse reaction 12.83 11.74 8 119185 29586 110440520
Pseudophaeochromocytoma 12.83 11.74 5 119188 130 110469976
Dry gangrene 12.80 11.74 10 119183 1054 110469052
Meningitis aseptic 12.80 11.74 31 119162 9839 110460267
Tooth infection 12.79 11.74 4 119189 22212 110447894
Osteopenia 12.78 11.74 4 119189 22205 110447901
Limb injury 12.77 11.74 13 119180 37623 110432483
Unevaluable event 12.77 11.74 28 119165 59199 110410907
Tenderness 12.71 11.74 8 119185 29429 110440677
Ischaemic hepatitis 12.70 11.74 20 119173 4628 110465478
Red blood cell agglutination 12.69 11.74 3 119190 12 110470094
Throat irritation 12.66 11.74 24 119169 53528 110416578
Stillbirth 12.56 11.74 19 119174 4245 110465861
Respiratory tract congestion 12.50 11.74 9 119184 30848 110439258
Pulmonary function test 12.49 11.74 3 119190 13 110470093
Staphylococcal bacteraemia 12.47 11.74 43 119150 16645 110453461
Multisystem inflammatory syndrome in children 12.44 11.74 4 119189 58 110470048
Urine glucose/creatinine ratio increased 12.42 11.74 5 119188 142 110469964
Cardiac valve abscess 12.42 11.74 5 119188 142 110469964
Lung infiltration 12.35 11.74 56 119137 24572 110445534
Base excess 12.31 11.74 4 119189 60 110470046
Femur fracture 12.30 11.74 18 119175 44451 110425655
Postictal psychosis 12.30 11.74 6 119187 271 110469835
Eye disorder 12.28 11.74 8 119185 28898 110441208
Anoxia 12.26 11.74 7 119186 437 110469669
Musculoskeletal discomfort 12.25 11.74 5 119188 23533 110446573
Haemoglobinuria 12.23 11.74 9 119184 868 110469238
Cardio-respiratory arrest 12.23 11.74 184 119009 115652 110354454
Antinuclear antibody negative 12.22 11.74 5 119188 148 110469958
Eosinophil count increased 12.19 11.74 50 119143 21008 110449098
Febrile bone marrow aplasia 12.19 11.74 44 119149 17421 110452685
Hernia 12.18 11.74 3 119190 19497 110450609
PCO2 decreased 12.16 11.74 16 119177 3145 110466961
Pollakiuria 12.12 11.74 18 119175 44177 110425929
Oxygen saturation decreased 12.09 11.74 237 118956 156745 110313361
Klebsiella test positive 12.01 11.74 14 119179 2432 110467674
Urosepsis 12.01 11.74 65 119128 30610 110439496
Escherichia sepsis 11.99 11.74 31 119162 10241 110459865
Periostosis 11.98 11.74 3 119190 16 110470090
Disseminated mucormycosis 11.98 11.74 13 119180 2089 110468017
Generalised oedema 11.98 11.74 65 119128 30639 110439467
Epidermolysis 11.91 11.74 10 119183 1168 110468938
Biliary dilatation 11.91 11.74 17 119176 3608 110466498
POEMS syndrome 11.90 11.74 4 119189 67 110470039
Dysbiosis 11.83 11.74 13 119180 2119 110467987
Coagulation factor V level decreased 11.82 11.74 8 119185 675 110469431
Epileptic encephalopathy 11.80 11.74 8 119185 677 110469429
Vitamin A deficiency 11.80 11.74 5 119188 162 110469944
Cytokine storm 11.77 11.74 11 119182 1479 110468627

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01DD04 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Third-generation cephalosporins
ATC J01DD54 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Third-generation cephalosporins
ATC J01DD63 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Third-generation cephalosporins
FDA CS M0003827 Cephalosporins
FDA EPC N0000175488 Cephalosporin Antibacterial
MeSH PA D000097902 beta Lactam Antibiotics
MeSH PA D000097911 Third Generation Cephalosporins
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
CHEBI has role CHEBI:35625 EC 3.5.2.6 (ฮฒ-lactamase) inhibitor
CHEBI has role CHEBI:36047 antibacterial drug
CHEBI has role CHEBI:88188 drug allergen
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:67079 anti-inflammatory agent

Related Drugs by ATC class:

J01DD Third-generation cephalosporins 17 drugs
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Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Gonococcal meningitis indication 151004
Streptococcal meningitis indication 4510004 DOID:11574
Septicemia due to Escherichia coli indication 9323009
Bacterial septicemia indication 10001005 DOID:0040085
Staphylococcal meningitis indication 12166008
Gonorrhea indication 15628003 DOID:7551
Infection of skin AND/OR subcutaneous tissue indication 19824006
Acute gonococcal cervicitis indication 20943002 DOID:10615
Staphylococcal pneumonia indication 22754005
Streptococcal septicemia indication 29577008
Acute gonococcal urethritis indication 29864006
Pneumonia due to Streptococcus indication 34020007
Gonorrhea of rectum indication 42746002
Gonococcal infection of joint indication 44743006
Bacterial arthritis indication 48245008
Salmonella septicemia indication 49786009
Lower respiratory tract infection indication 50417007
Pneumococcal meningitis indication 51169003
Pneumonia due to Escherichia coli indication 51530003
Bacterial pneumonia indication 53084003 DOID:874
Klebsiella cystitis indication 60867007
Gonococcal endocarditis indication 61048000
Acute gonococcal endometritis indication 65295003 DOID:7527
Haemophilus influenzae pneumonia indication 70036007
Infection due to Escherichia coli indication 71057007
Bacterial infection due to Serratia indication 71120004
Rhinoscleroma indication 72409005 DOID:11336
Gonorrhea of pharynx indication 74372003
Endometritis indication 78623009 DOID:1002
Bacterial meningitis indication 95883001 DOID:9470
Infection of bone indication 111253001
Staphylococcal septicemia indication 111821004
Female genital tract infection indication 125585007
Infectious disease of abdomen indication 128070006
Infection due to Enterobacteriaceae indication 128945009
Bacterial infection due to Klebsiella pneumoniae indication 186435004
Meningococcal meningitis indication 192644005
Escherichia coli meningitis indication 192655005
Proteus pneumonia indication 195888009
Chancroid indication 266143009 DOID:13778
Escherichia coli urinary tract infection indication 301011002
Proteus urinary tract infection indication 301012009
Streptococcus pyogenes infection indication 302809008
Bacterial urinary infection indication 312124009
Infective otitis media indication 312218008
Infectious disorder of joint indication 363162000
Meningitis due to Klebsiella mobilis indication 420585007
Peptostreptococcus infection indication 135341000119101
Klebsiella Pneumoniae Osteomyelitis indication
Inflammatory Disease of Female Pelvic Organs indication
Proteus Mirabilis Osteomyelitis indication
Peptostreptococcus Peritonitis indication
Enterobacter Pneumonia indication
Proteus Joint Infection indication
Haemophilus Septic Arthritis indication
Skin and Skin Structure Serratia Infection indication
E. Coli Peritonitis indication
Prevention of Perioperative Infection indication
Haemophilus Influenzae Type B Infections indication
Adult Gonococcal Conjunctivitis indication
E. Coli Septic Arthritis indication
Haemophilus Septicemia indication
Disseminated Gonococcal Infection indication
Klebsiella Pneumoniae Peritonitis indication
H. Influenzae Meningitis indication
Prevention of Meningococcal Meningitis indication
Gram-Negative Aerobic Bacillary Pneumonia indication
Skin and Skin Structure Proteus Infection indication
Haemophilus Osteomyelitis indication
Haemophilus Parainfluenzae Pneumonia indication
Enterobacter Osteomyelitis indication
Streptococcal Joint Infection indication
Pelvic Inflammatory Disease with Neisseria Gonorrhea indication
Klebsiella Joint Infection indication
EnterobacterJoint Infection indication
Skin and Skin Structure Morganella Morganii Infection indication
Streptococcus Osteomyelitis indication
E. Coli Joint Infection indication
E. Coli Osteomyelitis indication
Pyrexia of unknown origin off-label use 7520000
Lyme disease off-label use 23502006 DOID:11729
Lyme arthritis off-label use 33937009
Pseudotuberculosis off-label use 36753006
Lyme carditis off-label use 77863005
Infection by Yersinia enterocolitica off-label use 80960004
Ventilator-acquired pneumonia off-label use 429271009
Lyme Disease of the Central Nervous System off-label use
Sexual Transmitted Disease Exposure from Sexual Assault off-label use
Disorder of gallbladder contraindication 39621005 DOID:0060262
Acute nephropathy contraindication 58574008
Hemolytic anemia contraindication 61261009 DOID:583
Disease of liver contraindication 235856003 DOID:409
Neonatal hyperbilirubinemia contraindication 281610001
Pseudomembranous enterocolitis contraindication 397683000




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.65 acidic
pKa2 4.17 acidic
pKa3 13.31 acidic
pKa4 3.29 Basic
pKa5 0.93 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
D-amino-acid oxidase Enzyme IC50 5 CHEMBL
Alpha-synuclein Transporter Kd 6.28 CHEMBL
Peptidoglycan synthase FtsI Enzyme INHIBITOR IC50 6.14 WOMBAT-PK CHEMBL
Penicillin-binding protein 1A Enzyme INHIBITOR IC50 6.51 WOMBAT-PK CHEMBL
Penicillin-binding protein 1B Enzyme INHIBITOR IC50 5.74 WOMBAT-PK CHEMBL
Penicillin-binding protein 2 Enzyme INHIBITOR IC50 6.21 WOMBAT-PK CHEMBL

External reference:

IDSource
4019667 VUID
N0000147759 NUI
D00924 KEGG_DRUG
104376-79-6 SECONDARY_CAS_RN
203172 RXNORM
C0007561 UMLSCUI
CHEBI:29007 CHEBI
9F2 PDB_CHEM_ID
CHEMBL161 ChEMBL_ID
CHEMBL6067656 ChEMBL_ID
D002443 MESH_DESCRIPTOR_UI
DB01212 DRUGBANK_ID
5326 IUPHAR_LIGAND_ID
4923 INN_ID
75J73V1629 UNII
5479530 PUBCHEM_CID
4387 MMSL
69782 MMSL
d00052 MMSL
002734 NDDF
004849 NDDF
19841008 SNOMEDCT_US
33440000 SNOMEDCT_US
372670001 SNOMEDCT_US
4017814 VANDF
4019667 VANDF
75J73V1629 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9678 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 26 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9768 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 23 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9856 INJECTION, POWDER, FOR SOLUTION 2 g INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9857 INJECTION, POWDER, FOR SOLUTION 1 g INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9858 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9859 INJECTION, POWDER, FOR SOLUTION 250 mg INTRAMUSCULAR ANDA 24 sections
CEFTRIAXONE AND DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0264-3153 INJECTION, SOLUTION 1 g INTRAVENOUS NDA 27 sections
CEFTRIAXONE AND DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0264-3155 INJECTION, SOLUTION 2 g INTRAVENOUS NDA 27 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0338-5002 INJECTION, SOLUTION 1 g INTRAVENOUS ANDA 23 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0338-5003 INJECTION, SOLUTION 2 g INTRAVENOUS ANDA 23 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7332 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7332 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7333 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 19 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7333 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 19 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7334 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 25 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7334 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 25 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7335 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7335 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7336 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 19 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7336 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 19 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7337 INJECTION, POWDER, FOR SOLUTION 250 mg INTRAMUSCULAR ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7337 INJECTION, POWDER, FOR SOLUTION 250 mg INTRAMUSCULAR ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7338 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAMUSCULAR ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7338 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAMUSCULAR ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0781-3206 INJECTION, POWDER, FOR SOLUTION 250 mg INTRAMUSCULAR ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0781-3207 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAMUSCULAR ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0781-3208 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0781-3209 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0781-3210 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 22 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-202 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 23 sections