ceftriaxone ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, cefalosporanic acid derivatives 564 73384-59-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ceftriaxone sodium hydrate
  • ceftriaxone
  • biotrakson
  • rocefin
  • rocephalin
  • rophex
  • ceftriaxone sodium
A broad-spectrum cephalosporin antibiotic and cefotaxime derivative with a very long half-life and high penetrability to meninges, eyes and inner ears.
  • Molecular weight: 554.57
  • Formula: C18H18N8O7S3
  • CLOGP: -1.24
  • LIPINSKI: 2
  • HAC: 15
  • HDO: 4
  • TPSA: 208.98
  • ALOGS: -3.72
  • ROTB: 8

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2 g P
2 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 400 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 46 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 120.27 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 0 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.12 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.22 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.10 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 21, 1984 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 705.22 12.34 378 40513 28046 50536187
Toxic epidermal necrolysis 374.14 12.34 225 40666 20767 50543466
Acute generalised exanthematous pustulosis 352.52 12.34 163 40728 8775 50555458
Acute kidney injury 328.69 12.34 628 40263 227430 50336803
Pseudocholelithiasis 318.36 12.34 52 40839 0 50564233
Rash maculo-papular 250.02 12.34 192 40699 26449 50537784
Eosinophilia 230.94 12.34 159 40732 18493 50545740
Multiple organ dysfunction syndrome 228.95 12.34 241 40650 50096 50514137
Fatigue 207.54 12.34 162 40729 707439 49856794
Jarisch-Herxheimer reaction 196.34 12.34 46 40845 249 50563984
Off label use 183.07 12.34 812 40079 473614 50090619
Agranulocytosis 168.06 12.34 139 40752 21282 50542951
Pain 166.38 12.34 135 40756 578768 49985465
Joint swelling 161.81 12.34 9 40882 245277 50318956
Pyrexia 160.47 12.34 669 40222 379534 50184699
Cholestasis 155.30 12.34 143 40748 25258 50538975
Hepatitis 154.51 12.34 157 40734 31296 50532937
Stevens-Johnson syndrome 153.90 12.34 133 40758 21619 50542614
Cholelithiasis 148.55 12.34 168 40723 37805 50526428
Recalled product administered 147.36 12.34 40 40851 422 50563811
Septic shock 146.97 12.34 205 40686 56970 50507263
Drug interaction 146.96 12.34 423 40468 199198 50365035
Clostridium difficile colitis 138.91 12.34 115 40776 17627 50546606
Haemolytic anaemia 138.65 12.34 89 40802 9203 50555030
Electrocardiogram QT prolonged 137.80 12.34 189 40702 51697 50512536
Rheumatoid arthritis 131.82 12.34 8 40883 202542 50361691
Factor V inhibition 125.37 12.34 29 40862 147 50564086
Tubulointerstitial nephritis 124.12 12.34 101 40790 15110 50549123
Drug intolerance 122.90 12.34 16 40875 219088 50345145
Anaphylactic shock 122.29 12.34 113 40778 20042 50544191
Alopecia 121.64 12.34 25 40866 245022 50319211
Premature delivery 121.50 12.34 121 40770 23542 50540691
Arthralgia 120.07 12.34 107 40784 438595 50125638
Arthropathy 113.53 12.34 3 40888 157903 50406330
Postrenal failure 104.88 12.34 23 40868 87 50564146
Abdominal discomfort 102.55 12.34 30 40861 231611 50332622
Hepatocellular injury 101.81 12.34 115 40776 25832 50538401
Headache 99.78 12.34 160 40731 506375 50057858
Leukocytosis 93.61 12.34 103 40788 22476 50541757
Weight increased 87.80 12.34 27 40864 201864 50362369
Hepatitis cholestatic 87.35 12.34 57 40834 6060 50558173
Therapeutic product effect decreased 86.62 12.34 6 40885 136044 50428189
Swelling 85.33 12.34 28 40863 200844 50363389
Status epilepticus 84.90 12.34 77 40814 13329 50550904
Fall 84.19 12.34 88 40803 334844 50229389
Acute respiratory distress syndrome 83.60 12.34 94 40797 21005 50543228
Product dose omission issue 82.84 12.34 23 40868 183815 50380418
Drug-induced liver injury 81.68 12.34 107 40784 27988 50536245
Pemphigus 80.45 12.34 4 40887 120162 50444071
Pseudomembranous colitis 80.27 12.34 41 40850 2744 50561489
Glossodynia 80.17 12.34 3 40888 115566 50448667
Clostridium difficile infection 78.84 12.34 100 40791 25339 50538894
Contraindicated product administered 78.57 12.34 13 40878 148945 50415288
Thrombocytopenia 78.30 12.34 254 40637 127419 50436814
Encephalopathy 76.53 12.34 114 40777 33597 50530636
Respiratory failure 75.61 12.34 202 40689 90979 50473254
Systemic lupus erythematosus 74.78 12.34 12 40879 140610 50423623
Nasopharyngitis 73.41 12.34 32 40859 192895 50371338
Exposure during pregnancy 72.62 12.34 239 40652 120776 50443457
Peripheral swelling 72.49 12.34 38 40853 205898 50358335
Altered state of consciousness 70.88 12.34 88 40803 21822 50542411
Sepsis 70.57 12.34 252 40639 132673 50431560
Enterococcal infection 69.72 12.34 52 40839 6846 50557387
Long QT syndrome 66.66 12.34 37 40854 2930 50561303
Cardiac arrest 66.02 12.34 182 40709 83469 50480764
Haemophagocytic lymphohistiocytosis 65.57 12.34 55 40836 8578 50555655
Erythema 64.07 12.34 261 40630 146153 50418080
Transaminases increased 63.02 12.34 94 40797 27730 50536503
Neutropenia 62.57 12.34 261 40630 147704 50416529
Pain in extremity 61.68 12.34 78 40813 272787 50291446
Dermatitis exfoliative 61.66 12.34 43 40848 5099 50559134
Wound 61.04 12.34 7 40884 105787 50458446
Choreoathetosis 60.91 12.34 20 40871 421 50563812
Insomnia 60.45 12.34 33 40858 174832 50389401
Linear IgA disease 59.39 12.34 26 40865 1228 50563005
Bronchopulmonary aspergillosis 58.97 12.34 49 40842 7543 50556690
Pneumococcal infection 58.18 12.34 19 40872 393 50563840
Injection site pain 57.85 12.34 10 40881 111014 50453219
Toxic encephalopathy 56.69 12.34 42 40849 5473 50558760
Tachypnoea 56.14 12.34 64 40827 14513 50549720
Dizziness 56.06 12.34 123 40768 346246 50217987
Myasthenia gravis crisis 55.22 12.34 18 40873 370 50563863
Hypoxia 54.80 12.34 125 40766 50998 50513235
Acinetobacter infection 53.07 12.34 25 40866 1402 50562831
Tachycardia 52.80 12.34 189 40702 99574 50464659
Alveolitis 52.59 12.34 30 40861 2504 50561729
Torsade de pointes 52.57 12.34 56 40835 11779 50552454
Pericarditis 51.47 12.34 3 40888 78686 50485547
Contusion 50.57 12.34 14 40877 112169 50452064
Cholecystitis 50.23 12.34 59 40832 13812 50550421
Metabolic acidosis 49.70 12.34 102 40789 38723 50525510
Dermatitis bullous 48.99 12.34 43 40848 7130 50557103
Influenza B virus test positive 48.57 12.34 15 40876 257 50563976
Symmetrical drug-related intertriginous and flexural exanthema 48.33 12.34 16 40875 346 50563887
Anaphylactic reaction 48.10 12.34 123 40768 53932 50510301
No adverse event 47.52 12.34 92 40799 33486 50530747
Rash morbilliform 46.81 12.34 29 40862 2817 50561416
Musculoskeletal stiffness 46.23 12.34 23 40868 128458 50435775
Low birth weight baby 45.77 12.34 38 40853 5843 50558390
Discomfort 44.44 12.34 16 40875 108364 50455869
Drug ineffective for unapproved indication 44.10 12.34 69 40822 21212 50543021
Drug resistance 42.78 12.34 64 40827 18925 50545308
Acute respiratory failure 42.13 12.34 80 40811 28702 50535531
Urticaria 41.71 12.34 211 40680 129350 50434883
Psoriasis 41.25 12.34 4 40887 68996 50495237
Pancytopenia 40.93 12.34 155 40736 83875 50480358
Depression 40.88 12.34 44 40847 165379 50398854
Cholangitis 40.75 12.34 32 40859 4547 50559686
Pathogen resistance 40.66 12.34 35 40856 5654 50558579
Hypertransaminasaemia 40.52 12.34 29 40862 3582 50560651
Gait disturbance 40.39 12.34 37 40854 149968 50414265
Cross sensitivity reaction 40.03 12.34 23 40868 1946 50562287
Nosocomial infection 39.83 12.34 21 40870 1501 50562732
Weight decreased 39.64 12.34 74 40817 221171 50343062
Renal failure 38.88 12.34 180 40711 106453 50457780
Muscle spasms 38.78 12.34 27 40864 125526 50438707
Pleocytosis 37.97 12.34 15 40876 545 50563688
Pyuria 37.84 12.34 21 40870 1662 50562571
Nausea 37.61 12.34 377 40514 705021 49859212
Premature baby 37.37 12.34 59 40832 18278 50545955
Haemolysis 37.00 12.34 34 40857 5982 50558251
Injection site erythema 36.39 12.34 8 40883 74928 50489305
Malaise 35.57 12.34 145 40746 335387 50228846
Death 35.51 12.34 139 40752 325240 50238993
Hydronephrosis 35.46 12.34 39 40852 8502 50555731
Stenotrophomonas infection 35.29 12.34 20 40871 1649 50562584
Arthritis 35.21 12.34 13 40878 86708 50477525
Encephalitis 34.70 12.34 36 40855 7344 50556889
Guillain-Barre syndrome 34.67 12.34 26 40865 3451 50560782
SJS-TEN overlap 34.51 12.34 11 40880 210 50564023
Sinusitis 34.26 12.34 53 40838 170505 50393728
Haemodynamic instability 33.94 12.34 37 40854 7987 50556246
Hepatic cytolysis 33.64 12.34 37 40854 8066 50556167
Lower respiratory tract infection 32.82 12.34 18 40873 95183 50469050
Product use issue 32.42 12.34 44 40847 149431 50414802
Leukaemoid reaction 32.29 12.34 10 40881 173 50564060
CSF measles antibody positive 32.26 12.34 8 40883 57 50564176
Respiratory distress 32.05 12.34 74 40817 30415 50533818
Blood creatinine increased 31.88 12.34 134 40757 76026 50488207
Oliguria 31.51 12.34 36 40855 8180 50556053
Rubella antibody positive 31.45 12.34 8 40883 64 50564169
Migraine 31.05 12.34 11 40880 75269 50488964
Leukopenia 30.79 12.34 122 40769 67406 50496827
International normalised ratio increased 30.25 12.34 90 40801 43062 50521171
Product use in unapproved indication 30.11 12.34 178 40713 115641 50448592
Osteoarthritis 30.10 12.34 9 40882 68597 50495636
Alanine aminotransferase increased 29.91 12.34 146 40745 88213 50476020
Lip oedema 29.90 12.34 23 40868 3170 50561063
Laryngeal stenosis 29.75 12.34 14 40877 783 50563450
Shock 29.73 12.34 57 40834 20593 50543640
Angioedema 29.73 12.34 82 40809 37594 50526639
Rash erythematous 29.65 12.34 78 40813 34774 50529459
Gastrointestinal disorder 29.58 12.34 20 40871 94436 50469797
Blood brain barrier defect 29.42 12.34 8 40883 85 50564148
Helicobacter infection 29.40 12.34 3 40888 49699 50514534
Infusion related reaction 29.23 12.34 58 40833 169499 50394734
Mobility decreased 29.22 12.34 14 40877 79934 50484299
Clostridium test positive 28.83 12.34 19 40872 2053 50562180
Hypokalaemia 28.09 12.34 143 40748 87849 50476384
Enterobacter infection 27.95 12.34 18 40873 1870 50562363
Immune reconstitution inflammatory syndrome 27.92 12.34 28 40863 5488 50558745
Abdominal pain upper 27.89 12.34 54 40837 159255 50404978
Intentional overdose 27.79 12.34 8 40883 62496 50501737
Gastroenteritis clostridial 27.75 12.34 12 40879 550 50563683
Treatment failure 27.41 12.34 43 40848 137594 50426639
Autoimmune haemolytic anaemia 27.36 12.34 24 40867 3975 50560258
Aspartate aminotransferase increased 27.20 12.34 130 40761 77868 50486365
Bile duct stone 27.06 12.34 22 40869 3285 50560948
Hepatic function abnormal 26.65 12.34 72 40819 32609 50531624
Pelvic inflammatory disease 26.28 12.34 16 40875 1506 50562727
CSF protein increased 26.21 12.34 11 40880 468 50563765
Ill-defined disorder 26.20 12.34 6 40885 54648 50509585
Cyanosis 25.76 12.34 45 40846 15139 50549094
Factor V deficiency 25.69 12.34 7 40884 75 50564158
Eosinophilic pneumonia 25.38 12.34 17 40874 1887 50562346
Haemoperitoneum 25.24 12.34 19 40872 2536 50561697
Bacteriuria 25.21 12.34 12 40879 689 50563544
Blood pressure increased 25.20 12.34 43 40848 133089 50431144
Klebsiella infection 25.05 12.34 30 40861 7164 50557069
Stomatitis 24.97 12.34 27 40864 101317 50462916
Weber tuning fork test abnormal 24.97 12.34 7 40884 84 50564149
Thunderclap headache 24.94 12.34 8 40883 156 50564077
Hepatitis infectious mononucleosis 24.89 12.34 7 40884 85 50564148
Back pain 24.62 12.34 93 40798 219937 50344296
Intervertebral discitis 24.58 12.34 19 40872 2637 50561596
Hyporesponsive to stimuli 24.53 12.34 13 40878 939 50563294
Myopathy toxic 24.43 12.34 10 40881 399 50563834
Systemic inflammatory response syndrome 24.41 12.34 25 40866 5024 50559209
Hypotension 24.33 12.34 294 40597 235175 50329058
Clostridium colitis 24.22 12.34 16 40875 1736 50562497
Face oedema 24.17 12.34 48 40843 17791 50546442
Neurotoxicity 24.13 12.34 43 40848 14697 50549536
Fibrin D dimer increased 24.08 12.34 23 40868 4249 50559984
Erythema multiforme 24.05 12.34 33 40858 9017 50555216
Renal tubular necrosis 23.95 12.34 35 40856 10133 50554100
Myocardial infarction 23.90 12.34 22 40869 89005 50475228
Organic brain syndrome 23.66 12.34 8 40883 185 50564048
Pyelonephritis 23.61 12.34 43 40848 14946 50549287
Neutrophilia 23.55 12.34 21 40870 3554 50560679
Bronchial obstruction 23.41 12.34 14 40877 1276 50562957
Pyelonephritis acute 23.05 12.34 22 40869 4061 50560172
Electrolyte imbalance 23.03 12.34 46 40845 17123 50547110
Maternal exposure during pregnancy 22.83 12.34 213 40678 159565 50404668
Toxic skin eruption 22.64 12.34 36 40855 11215 50553018
Otitis media acute 22.57 12.34 12 40879 872 50563361
Unresponsive to stimuli 22.56 12.34 65 40826 30544 50533689
Feeling abnormal 22.43 12.34 42 40849 125450 50438783
Cardiogenic shock 22.38 12.34 43 40848 15556 50548677
Renal papillary necrosis 22.25 12.34 8 40883 223 50564010
Cholestatic liver injury 22.15 12.34 16 40875 2005 50562228
Abdominal wall haematoma 22.12 12.34 18 40873 2690 50561543
Meningism 22.11 12.34 9 40882 354 50563879
Type I hypersensitivity 21.94 12.34 17 40874 2368 50561865
Hospitalisation 21.79 12.34 14 40877 67923 50496310
Toxicity to various agents 21.76 12.34 93 40798 212406 50351827
Haemostasis 21.73 12.34 8 40883 239 50563994
Folliculitis 21.63 12.34 3 40888 39222 50525011
Haemodialysis 21.48 12.34 30 40861 8332 50555901
Aspergillus infection 21.42 12.34 27 40864 6794 50557439
Suicidal ideation 21.33 12.34 9 40882 55376 50508857
Stress cardiomyopathy 21.32 12.34 29 40862 7858 50556375
Anuria 21.30 12.34 35 40856 11209 50553024
Hypertension 21.28 12.34 93 40798 211110 50353123
Drug abuse 21.09 12.34 11 40880 59835 50504398
Morganella infection 20.99 12.34 10 40881 575 50563658
Nephropathy toxic 20.92 12.34 29 40862 8000 50556233
Disseminated intravascular coagulation 20.73 12.34 44 40847 17091 50547142
Balance disorder 20.72 12.34 16 40875 70574 50493659
Intravascular haemolysis 20.67 12.34 8 40883 275 50563958
Cholangitis acute 20.62 12.34 9 40882 422 50563811
Iris transillumination defect 20.62 12.34 6 40885 83 50564150
Hyperthyroidism 20.55 12.34 36 40855 12139 50552094
Veillonella infection 20.50 12.34 5 40886 33 50564200
Meningitis 20.46 12.34 25 40866 6096 50558137
Inflammatory marker increased 20.45 12.34 24 40867 5610 50558623
Coagulation factor deficiency 20.45 12.34 4 40887 7 50564226
Jaundice 20.33 12.34 57 40834 26372 50537861
Dry mouth 20.28 12.34 10 40881 56168 50508065
Impaired healing 20.26 12.34 16 40875 69770 50494463
Normal newborn 20.24 12.34 26 40865 6665 50557568
Laryngeal mass 20.24 12.34 5 40886 35 50564198
Hepatosplenomegaly 20.23 12.34 16 40875 2296 50561937
Nasal congestion 20.19 12.34 8 40883 51112 50513121
Erythema nodosum 20.10 12.34 20 40871 3883 50560350
Multiple sclerosis relapse 20.04 12.34 5 40886 42959 50521274
Eosinophilic pneumonia acute 19.96 12.34 8 40883 302 50563931
COVID-19 pneumonia 19.92 12.34 29 40862 8366 50555867
Septic pulmonary embolism 19.66 12.34 5 40886 40 50564193
Acquired haemophilia 19.58 12.34 11 40880 892 50563341
Cataract 19.35 12.34 7 40884 47293 50516940
Palpitations 19.31 12.34 29 40862 94477 50469756
Anxiety 19.26 12.34 76 40815 177530 50386703
Drug eruption 19.24 12.34 52 40839 23554 50540679
Coagulation factor decreased 19.23 12.34 5 40886 44 50564189
Postpartum sepsis 19.21 12.34 4 40887 11 50564222
Blood pressure fluctuation 19.15 12.34 3 40888 35820 50528413
Respiratory acidosis 19.15 12.34 24 40867 6004 50558229
Hypoaesthesia 19.07 12.34 47 40844 127210 50437023
Endocarditis 18.95 12.34 22 40869 5085 50559148
Transverse sinus thrombosis 18.93 12.34 9 40882 515 50563718
Bronchopleural fistula 18.86 12.34 7 40884 214 50564019
Encephalitis brain stem 18.70 12.34 6 40885 117 50564116
Agitation 18.62 12.34 89 40802 53295 50510938
Memory impairment 18.61 12.34 22 40869 79338 50484895
Liver injury 18.59 12.34 53 40838 24753 50539480
Pneumonia necrotising 18.39 12.34 8 40883 372 50563861
Hypercreatininaemia 18.37 12.34 8 40883 373 50563860
Anti factor V antibody 18.37 12.34 3 40888 0 50564233
Red blood cell agglutination 18.37 12.34 3 40888 0 50564233
Unmasking of previously unidentified disease 18.30 12.34 10 40881 768 50563465
Influenza like illness 18.21 12.34 12 40879 57447 50506786
Hepatic enzyme increased 18.14 12.34 54 40837 137326 50426907
Gastrooesophageal reflux disease 18.13 12.34 21 40870 76407 50487826
Partial seizures 18.12 12.34 21 40870 4844 50559389
Dyspepsia 17.96 12.34 20 40871 74077 50490156
Dermatitis exfoliative generalised 17.94 12.34 17 40874 3109 50561124
Cerebral artery stenosis 17.92 12.34 8 40883 396 50563837
Condition aggravated 17.84 12.34 338 40553 296720 50267513
Drug hypersensitivity 17.70 12.34 293 40598 250717 50313516
Asymptomatic bacteriuria 17.62 12.34 7 40884 258 50563975
Nocardiosis 17.61 12.34 13 40878 1685 50562548
Hyperglycaemia 17.58 12.34 67 40824 36338 50527895
Hypofibrinogenaemia 17.45 12.34 11 40880 1101 50563132
Hyperlactacidaemia 17.45 12.34 15 40876 2418 50561815
Conjunctival hyperaemia 17.35 12.34 14 40877 2068 50562165
Wound haemorrhage 17.30 12.34 14 40877 2076 50562157
Rash 17.26 12.34 469 40422 437002 50127231
Infantile apnoea 17.22 12.34 10 40881 863 50563370
Hyperbilirubinaemia 17.07 12.34 29 40862 9541 50554692
Normochromic anaemia 17.04 12.34 7 40884 282 50563951
Adverse event 17.03 12.34 7 40884 43756 50520477
Skin test positive 17.03 12.34 9 40882 646 50563587
Relapsing fever 16.97 12.34 6 40885 159 50564074
Confabulation 16.88 12.34 7 40884 289 50563944
Sleep disorder 16.79 12.34 13 40878 57270 50506963
Hepatitis acute 16.75 12.34 26 40865 7935 50556298
Pseudophaeochromocytoma 16.69 12.34 5 40886 77 50564156
Injection site pruritus 16.50 12.34 6 40885 40405 50523828
Hypoalbuminaemia 16.44 12.34 29 40862 9831 50554402
Purpura 16.33 12.34 29 40862 9882 50554351
Antibiotic associated colitis 16.29 12.34 3 40888 3 50564230
Fibromyalgia 16.25 12.34 8 40883 44970 50519263
Encephalitis autoimmune 16.21 12.34 11 40880 1247 50562986
Clostridial infection 16.18 12.34 18 40873 3972 50560261
Stomatococcal infection 16.17 12.34 5 40886 86 50564147
Hyperthermia malignant 16.01 12.34 9 40882 730 50563503
Eyelid oedema 15.99 12.34 28 40863 9438 50554795
Musculoskeletal pain 15.89 12.34 21 40870 72156 50492077
Normocytic anaemia 15.68 12.34 11 40880 1316 50562917
Gamma-glutamyltransferase increased 15.55 12.34 56 40835 29567 50534666
Escherichia infection 15.50 12.34 30 40861 10911 50553322
Haematoma 15.44 12.34 57 40834 30453 50533780
Cerebral aspergillosis 15.43 12.34 7 40884 360 50563873
Myocarditis 15.41 12.34 25 40866 7922 50556311
Nephritis 15.38 12.34 13 40878 2049 50562184
Vision blurred 15.24 12.34 25 40866 78622 50485611
Type IV hypersensitivity reaction 15.21 12.34 14 40877 2468 50561765
Herpes zoster 15.17 12.34 21 40870 70765 50493468
Dry skin 15.13 12.34 8 40883 43183 50521050
Post treatment Lyme disease syndrome 15.07 12.34 3 40888 6 50564227
Anaemia 15.06 12.34 287 40604 252169 50312064
Neisseria infection 15.02 12.34 4 40887 39 50564194
Anoxia 14.96 12.34 6 40885 227 50564006
Foetal death 14.87 12.34 25 40866 8155 50556078
Pneumonia mycoplasmal 14.85 12.34 9 40882 840 50563393
Mixed liver injury 14.74 12.34 16 40875 3435 50560798
Candida test positive 14.71 12.34 9 40882 855 50563378
Orthostatic hypotension 14.61 12.34 3 40888 29478 50534755
CSF oligoclonal band present 14.57 12.34 5 40886 121 50564112
Ventricular dysfunction 14.56 12.34 14 40877 2607 50561626
Hemianopia 14.54 12.34 9 40882 873 50563360
Vitamin K deficiency 14.48 12.34 7 40884 416 50563817
Overlap syndrome 14.41 12.34 8 40883 634 50563599
Brain herniation 14.39 12.34 15 40876 3077 50561156
Meningitis bacterial 14.35 12.34 10 40881 1184 50563049
Anti-platelet antibody positive 14.34 12.34 4 40887 47 50564186
Hypertensive heart disease 14.29 12.34 13 40878 2257 50561976
Chemotherapeutic drug level increased 14.02 12.34 5 40886 136 50564097
Visual impairment 13.90 12.34 21 40870 68254 50495979
Systemic candida 13.82 12.34 14 40877 2776 50561457
Ventricular fibrillation 13.81 12.34 28 40863 10531 50553702
Ear pain 13.77 12.34 3 40888 28280 50535953
Superior sagittal sinus thrombosis 13.69 12.34 8 40883 699 50563534
Cardiac tamponade 13.68 12.34 17 40874 4215 50560018
Stress 13.62 12.34 14 40877 53779 50510454
Thrombosis 13.61 12.34 15 40876 55818 50508415
Therapeutic product effect incomplete 13.55 12.34 34 40857 91481 50472752
Bronchospasm 13.41 12.34 34 40857 14820 50549413
Hypoxic-ischaemic encephalopathy 13.34 12.34 16 40875 3826 50560407
Hyperthermia 13.31 12.34 23 40868 7673 50556560
Cholecystitis acute 13.30 12.34 22 40869 7084 50557149
Microangiopathic haemolytic anaemia 13.29 12.34 7 40884 499 50563734
Ureterolithiasis 13.29 12.34 11 40880 1684 50562549
Acute hepatic failure 13.24 12.34 35 40856 15642 50548591
Alpha 1 microglobulin increased 13.21 12.34 4 40887 64 50564169
Leukoencephalopathy 13.21 12.34 16 40875 3867 50560366
Pallor 13.16 12.34 45 40846 23154 50541079
Tracheobronchitis 13.15 12.34 9 40882 1035 50563198
Muscle haemorrhage 13.14 12.34 14 40877 2944 50561289
Fluid retention 13.03 12.34 13 40878 50636 50513597
Bacteraemia 12.99 12.34 33 40858 14400 50549833
Neuroglycopenia 12.87 12.34 4 40887 70 50564163
Inappropriate schedule of product administration 12.86 12.34 24 40867 71807 50492426
Kidney enlargement 12.82 12.34 7 40884 537 50563696
Neuropathy peripheral 12.79 12.34 38 40853 96719 50467514
Brain abscess 12.76 12.34 11 40880 1780 50562453
Septic embolus 12.64 12.34 8 40883 807 50563426
Hyperkalaemia 12.54 12.34 74 40817 48015 50516218
Infection 12.53 12.34 85 40806 172869 50391364
Central nervous system vasculitis 12.52 12.34 8 40883 820 50563413
Base excess 12.47 12.34 4 40887 78 50564155
Coombs negative haemolytic anaemia 12.45 12.34 5 40886 190 50564043
Respiratory disorder 12.37 12.34 54 40837 31133 50533100
Stridor 12.35 12.34 14 40877 3155 50561078

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 427.43 12.21 1203 43566 299597 29230161
Drug reaction with eosinophilia and systemic symptoms 346.11 12.21 308 44461 27684 29502074
Postrenal failure 292.14 12.21 77 44692 348 29529410
Jarisch-Herxheimer reaction 260.51 12.21 69 44700 319 29529439
Pseudocholelithiasis 214.31 12.21 39 44730 0 29529758
Rash maculo-papular 177.50 12.21 201 44568 24088 29505670
Acute kidney injury 156.87 12.21 803 43966 264464 29265294
Acute generalised exanthematous pustulosis 150.70 12.21 98 44671 5485 29524273
Cholestasis 146.26 12.21 179 44590 23283 29506475
Cholelithiasis 145.83 12.21 160 44609 18512 29511246
Appendicolith 142.96 12.21 80 44689 3400 29526358
Fatigue 140.73 12.21 164 44605 316657 29213101
Death 136.54 12.21 192 44577 341892 29187866
Toxic epidermal necrolysis 133.93 12.21 151 44618 18002 29511756
Eosinophilia 133.19 12.21 166 44603 21995 29507763
Hepatocellular injury 132.29 12.21 162 44607 21081 29508677
Hypertransaminasaemia 121.82 12.21 73 44696 3533 29526225
Multiple organ dysfunction syndrome 110.57 12.21 274 44495 62842 29466916
Anaphylactic shock 107.12 12.21 116 44653 13220 29516538
Pyrexia 106.25 12.21 771 43998 286851 29242907
Agranulocytosis 104.47 12.21 141 44628 20199 29509559
Toxic encephalopathy 100.71 12.21 71 44698 4541 29525217
Hepatitis 100.60 12.21 140 44629 20643 29509115
Product dose omission issue 96.97 12.21 15 44754 96368 29433390
Anaphylactic reaction 95.55 12.21 159 44610 27414 29502344
Appendicitis 95.51 12.21 90 44679 8689 29521069
Cardiogenic shock 95.48 12.21 131 44638 19059 29510699
Ureterolithiasis 94.31 12.21 49 44720 1791 29527967
Pathogen resistance 93.70 12.21 86 44683 8030 29521728
Drug abuse 91.34 12.21 8 44761 79875 29449883
Haemolytic anaemia 88.31 12.21 89 44680 9330 29520428
Long QT syndrome 87.59 12.21 50 44719 2208 29527550
Drug-induced liver injury 86.16 12.21 133 44636 21522 29508236
Recalled product administered 84.11 12.21 30 44739 422 29529336
Dizziness 79.95 12.21 102 44667 189582 29340176
Depression 79.65 12.21 16 44753 85131 29444627
Myocardial infarction 75.92 12.21 36 44733 110260 29419498
Fall 74.95 12.21 95 44674 177083 29352675
Clostridium difficile colitis 74.65 12.21 96 44673 13116 29516642
Bronchopulmonary aspergillosis 71.81 12.21 91 44678 12253 29517505
Immune reconstitution inflammatory syndrome 70.00 12.21 72 44697 7730 29522028
Haemolysis 69.41 12.21 68 44701 6888 29522870
Alanine aminotransferase increased 68.86 12.21 250 44519 70694 29459064
Septic shock 67.23 12.21 228 44541 62332 29467426
Factor V inhibition 66.98 12.21 20 44749 153 29529605
Weight increased 66.51 12.21 17 44752 76650 29453108
Hydronephrosis 63.32 12.21 72 44697 8658 29521100
Tubulointerstitial nephritis 58.79 12.21 100 44669 17543 29512215
Electrocardiogram QT prolonged 58.15 12.21 152 44617 35985 29493773
Respiratory failure 54.92 12.21 291 44478 96840 29432918
Transaminases increased 50.22 12.21 108 44661 22554 29507204
Anuria 48.76 12.21 66 44703 9475 29520283
Pain 48.74 12.21 118 44651 171314 29358444
Stevens-Johnson syndrome 47.86 12.21 88 44681 16409 29513349
Insomnia 47.22 12.21 39 44730 88722 29441036
Cerebrovascular accident 47.20 12.21 29 44740 76882 29452876
Nocardiosis 46.57 12.21 39 44730 3221 29526537
Liver injury 46.40 12.21 75 44694 12615 29517143
Acute respiratory distress syndrome 45.98 12.21 105 44664 22830 29506928
Brain abscess 44.78 12.21 35 44734 2620 29527138
Inflammatory marker increased 44.56 12.21 40 44729 3627 29526131
Thrombocytopenia 44.20 12.21 352 44417 134471 29395287
Blood glucose increased 44.15 12.21 17 44752 58967 29470791
Disseminated intravascular coagulation 44.02 12.21 95 44674 19885 29509873
Pruritus 43.88 12.21 315 44454 116534 29413224
Cross sensitivity reaction 43.80 12.21 26 44743 1236 29528522
Hospitalisation 42.24 12.21 9 44760 45979 29483779
Ureteral disorder 41.42 12.21 14 44755 166 29529592
Joint swelling 41.16 12.21 12 44757 49618 29480140
Product use in unapproved indication 39.72 12.21 246 44523 86629 29443129
Klebsiella infection 39.33 12.21 52 44717 7297 29522461
Toxicity to various agents 38.77 12.21 134 44635 173527 29356231
Anxiety 37.90 12.21 44 44725 85321 29444437
Disseminated cryptococcosis 37.60 12.21 23 44746 1155 29528603
Cryptococcal meningoencephalitis 37.53 12.21 12 44757 118 29529640
Abdominal discomfort 37.21 12.21 13 44756 47890 29481868
COVID-19 pneumonia 37.19 12.21 58 44711 9464 29520294
Ascites 37.16 12.21 131 44638 36488 29493270
Portal fibrosis 36.94 12.21 15 44754 306 29529452
Liver function test increased 36.51 12.21 65 44704 11820 29517938
Hepatitis toxic 36.14 12.21 27 44742 1889 29527869
Arthralgia 35.91 12.21 101 44668 139516 29390242
Ventricular fibrillation 35.70 12.21 76 44693 15757 29514001
Cardiac failure congestive 35.61 12.21 38 44731 76543 29453215
Condition aggravated 35.13 12.21 357 44412 145938 29383820
Drug resistance 35.04 12.21 91 44678 21449 29508309
Kounis syndrome 35.01 12.21 26 44743 1803 29527955
Fixed eruption 34.66 12.21 22 44747 1180 29528578
Pain in extremity 34.62 12.21 72 44697 110361 29419397
Drug ineffective for unapproved indication 34.12 12.21 70 44699 14144 29515614
Torsade de pointes 33.92 12.21 46 44723 6615 29523143
Flank pain 33.57 12.21 43 44726 5850 29523908
Hyperferritinaemia 32.84 12.21 14 44755 324 29529434
Hepatitis cholestatic 32.69 12.21 46 44723 6847 29522911
Trichosporon infection 32.68 12.21 17 44752 623 29529135
Asthenia 32.49 12.21 192 44577 215058 29314700
Toxic skin eruption 32.10 12.21 55 44714 9702 29520056
Crying 31.99 12.21 40 44729 5311 29524447
Rash morbilliform 31.90 12.21 28 44741 2465 29527293
Hepatic enzyme increased 31.82 12.21 118 44651 33681 29496077
Muscle spasms 31.73 12.21 31 44738 65051 29464707
Feeling abnormal 31.40 12.21 22 44747 54423 29475335
Clostridium difficile infection 31.36 12.21 73 44696 16068 29513690
Hyponatraemia 31.20 12.21 192 44577 67441 29462317
Stress 31.15 12.21 87 44682 21403 29508355
Urticaria 31.01 12.21 164 44605 54496 29475262
Pseudomembranous colitis 30.91 12.21 28 44741 2569 29527189
Nasopharyngitis 30.76 12.21 27 44742 59638 29470120
Alcohol intolerance 30.75 12.21 14 44755 381 29529377
Choreoathetosis 30.24 12.21 19 44750 1001 29528757
Hepatomegaly 29.97 12.21 52 44717 9265 29520493
Inappropriate schedule of product administration 29.83 12.21 15 44754 44457 29485301
Coronary artery disease 29.50 12.21 15 44754 44175 29485583
Drug interaction 29.31 12.21 440 44329 196945 29332813
Encephalitis 29.15 12.21 42 44727 6388 29523370
Cardiac disorder 29.13 12.21 10 44759 37253 29492505
Aspartate aminotransferase increased 29.11 12.21 172 44597 59553 29470205
Malignant mesenteric neoplasm 29.05 12.21 8 44761 44 29529714
Sphincter of Oddi dysfunction 29.04 12.21 10 44759 126 29529632
Intentional overdose 29.00 12.21 11 44758 38517 29491241
Hepatitis acute 28.99 12.21 42 44727 6420 29523338
Hypoxia 28.85 12.21 145 44624 47234 29482524
Acute hepatic failure 28.85 12.21 59 44710 11893 29517865
Drug intolerance 28.63 12.21 19 44750 48360 29481398
Procalcitonin increased 28.46 12.21 22 44747 1620 29528138
Neutropenia 28.14 12.21 314 44455 131397 29398361
Leukocytosis 28.13 12.21 83 44686 21059 29508699
Diarrhoea 28.02 12.21 346 44423 332352 29197406
Dry gangrene 27.76 12.21 13 44756 378 29529380
No adverse event 27.57 12.21 73 44696 17405 29512353
Hyper IgE syndrome 27.53 12.21 8 44761 55 29529703
Hepatic function abnormal 27.42 12.21 125 44644 39134 29490624
Tachypnoea 26.82 12.21 66 44703 15049 29514709
Dehydration 26.63 12.21 87 44682 114661 29415097
Therapeutic product effect decreased 26.57 12.21 6 44763 29445 29500313
Corynebacterium infection 26.52 12.21 13 44756 419 29529339
Cyanosis 26.47 12.21 55 44714 11212 29518546
Device related sepsis 26.03 12.21 25 44744 2470 29527288
Suicidal ideation 25.98 12.21 10 44759 34706 29495052
Jejunal ulcer perforation 25.85 12.21 8 44761 70 29529688
Jaundice 25.69 12.21 100 44669 29196 29500562
Janeway lesion 25.48 12.21 6 44763 15 29529743
Metastases to stomach 25.26 12.21 8 44761 76 29529682
Pleocytosis 25.20 12.21 13 44756 468 29529290
Neurotoxicity 25.08 12.21 63 44706 14550 29515208
Bacterial pericarditis 25.05 12.21 7 44762 41 29529717
Myasthenia gravis crisis 24.95 12.21 13 44756 478 29529280
Contusion 24.91 12.21 8 44761 31087 29498671
Headache 24.78 12.21 158 44611 173849 29355909
Escherichia infection 24.76 12.21 40 44729 6724 29523034
Gait disturbance 24.55 12.21 46 44723 73303 29456455
Angina pectoris 24.48 12.21 6 44763 27844 29501914
Candida infection 24.43 12.21 64 44705 15161 29514597
Enterobacter infection 24.35 12.21 22 44747 2012 29527746
Drug effective for unapproved indication 24.15 12.21 19 44750 1436 29528322
Crystalluria 24.03 12.21 12 44757 403 29529355
Erythema 23.97 12.21 196 44573 75410 29454348
Chest pain 23.89 12.21 88 44681 111885 29417873
Acute respiratory failure 23.87 12.21 91 44678 26311 29503447
Wrong technique in product usage process 23.61 12.21 9 44760 31419 29498339
Coagulopathy 23.54 12.21 70 44699 17837 29511921
COVID-19 23.19 12.21 112 44657 35902 29493856
Sepsis 23.10 12.21 323 44446 142359 29387399
Cerebral cyst 22.89 12.21 10 44759 246 29529512
Blood alkaline phosphatase increased 22.55 12.21 94 44675 28312 29501446
Malignant neoplasm progression 22.43 12.21 49 44720 73810 29455948
Mucormycosis 22.38 12.21 33 44736 5125 29524633
Muscle abscess 22.38 12.21 12 44757 468 29529290
Omental necrosis 22.26 12.21 6 44763 30 29529728
Respiratory distress 22.25 12.21 102 44667 32004 29497754
Oliguria 22.08 12.21 40 44729 7372 29522386
Infective chondritis 22.00 12.21 5 44764 10 29529748
Antimicrobial susceptibility test resistant 21.97 12.21 10 44759 272 29529486
Eastern Cooperative Oncology Group performance status 21.79 12.21 6 44763 33 29529725
Tissue infiltration 21.70 12.21 7 44762 71 29529687
Clostridium test positive 21.69 12.21 21 44748 2096 29527662
Erythema nodosum 21.65 12.21 15 44754 932 29528826
Splenomegaly 21.49 12.21 56 44713 13223 29516535
Weight decreased 21.49 12.21 137 44632 150768 29378990
Prostate cancer 21.48 12.21 6 44763 25521 29504237
Coagulation factor decreased 21.27 12.21 7 44762 76 29529682
Procalcitonin abnormal 21.00 12.21 10 44759 302 29529456
Type IV hypersensitivity reaction 20.94 12.21 16 44753 1158 29528600
Pulmonary physical examination abnormal 20.82 12.21 5 44764 14 29529744
Rash 20.81 12.21 403 44366 189416 29340342
Malaise 20.68 12.21 149 44620 159453 29370305
Bile duct stone 20.67 12.21 21 44748 2221 29527537
Dry mouth 20.55 12.21 4 44765 21780 29507978
Balance disorder 20.35 12.21 15 44754 36155 29493603
Red blood cell schistocytes present 20.18 12.21 9 44760 233 29529525
Liver transplant failure 20.06 12.21 7 44762 92 29529666
Mobility decreased 20.01 12.21 7 44762 25773 29503985
Faeces pale 19.95 12.21 16 44753 1243 29528515
Endocarditis 19.83 12.21 33 44736 5683 29524075
Hypertension 19.76 12.21 100 44669 116514 29413244
Vision blurred 19.73 12.21 19 44750 40157 29489601
Serum sickness-like reaction 19.72 12.21 7 44762 97 29529661
Drug dependence 19.48 12.21 4 44765 20977 29508781
Antinuclear antibody negative 19.46 12.21 5 44764 20 29529738
Incorrect dose administered 19.45 12.21 13 44756 32971 29496787
Memory impairment 19.41 12.21 16 44753 36454 29493304
Syncope 19.35 12.21 61 44708 81310 29448448
Cataract 19.32 12.21 5 44764 22373 29507385
Calculus urinary 19.04 12.21 15 44754 1136 29528622
Overdose 18.87 12.21 60 44709 79759 29449999
Infective spondylitis 18.85 12.21 8 44761 183 29529575
Haemophagocytic lymphohistiocytosis 18.78 12.21 46 44723 10458 29519300
Peripheral swelling 18.77 12.21 43 44726 63696 29466062
Hyperamylasaemia 18.64 12.21 11 44758 517 29529241
Interleukin-2 receptor increased 18.63 12.21 7 44762 115 29529643
Transient ischaemic attack 18.62 12.21 6 44763 23264 29506494
Dyspnoea 18.58 12.21 366 44403 326366 29203392
Neuropathy peripheral 18.52 12.21 51 44718 70976 29458782
Vascular purpura 18.44 12.21 16 44753 1387 29528371
Allergy test positive 18.39 12.21 5 44764 26 29529732
Diabetes mellitus 18.24 12.21 20 44749 39811 29489947
Loss of personal independence in daily activities 17.95 12.21 8 44761 25432 29504326
Shock 17.91 12.21 72 44697 21332 29508426
Gastrooesophageal reflux disease 17.80 12.21 13 44756 31483 29498275
Erectile dysfunction 17.65 12.21 3 44766 18006 29511752
Vanishing bile duct syndrome 17.55 12.21 11 44758 577 29529181
Hypofibrinogenaemia 17.50 12.21 16 44753 1485 29528273
Bronchopleural fistula 17.38 12.21 10 44759 448 29529310
Henoch-Schonlein purpura 17.28 12.21 15 44754 1301 29528457
Hepatitis fulminant 17.18 12.21 24 44745 3547 29526211
Morganella infection 17.12 12.21 10 44759 461 29529297
Gamma-glutamyltransferase increased 17.10 12.21 83 44686 26654 29503104
Drug eruption 17.07 12.21 60 44709 16681 29513077
Osteomyelitis fungal 17.07 12.21 8 44761 233 29529525
ADAMTS13 activity decreased 17.05 12.21 6 44763 81 29529677
Lymphopenia 16.94 12.21 52 44717 13481 29516277
Suicide attempt 16.90 12.21 16 44753 34094 29495664
Encephalopathy 16.82 12.21 92 44677 30951 29498807
Prothrombin time ratio decreased 16.81 12.21 9 44760 350 29529408
Cholangitis 16.78 12.21 36 44733 7501 29522257
Renal papillary necrosis 16.75 12.21 7 44762 154 29529604
Low birth weight baby 16.40 12.21 33 44736 6575 29523183
Nail bed bleeding 16.33 12.21 5 44764 42 29529716
Intentional product misuse 16.32 12.21 17 44752 34644 29495114
Drug ineffective 16.30 12.21 688 44081 362482 29167276
Erythema multiforme 16.21 12.21 36 44733 7681 29522077
Herpes zoster reactivation 16.20 12.21 8 44761 262 29529496
Shock haemorrhagic 16.20 12.21 41 44728 9510 29520248
Basal cell carcinoma 16.17 12.21 3 44766 16907 29512851
Orthostatic hypotension 16.15 12.21 7 44762 22622 29507136
Intracranial pressure increased 16.15 12.21 23 44746 3462 29526296
Aggression 16.11 12.21 18 44751 35523 29494235
Peritoneal dialysis 16.08 12.21 10 44759 517 29529241
Back pain 16.05 12.21 90 44679 102194 29427564
Pneumonia bacterial 15.74 12.21 40 44729 9303 29520455
Coronavirus infection 15.68 12.21 22 44747 3266 29526492
Carotid artery insufficiency 15.57 12.21 4 44765 16 29529742
Stomatitis 15.54 12.21 20 44749 37093 29492665
Chondrocalcinosis 15.51 12.21 8 44761 288 29529470
Meningitis bacterial 15.31 12.21 13 44756 1094 29528664
Cerebellar syndrome 15.27 12.21 17 44752 1997 29527761
Human T-cell lymphotropic virus type I infection 15.19 12.21 4 44765 18 29529740
Injection site pain 15.18 12.21 16 44753 32430 29497328
Blood pressure increased 15.08 12.21 59 44710 73744 29456014
Encephalomalacia 15.08 12.21 11 44758 742 29529016
Sleep apnoea syndrome 15.06 12.21 4 44765 17595 29512163
Musculoskeletal pain 15.04 12.21 13 44756 28940 29500818
Hypoaesthesia 15.00 12.21 37 44732 53430 29476328
Strongyloidiasis 14.98 12.21 18 44751 2294 29527464
Psoriasis 14.96 12.21 16 44753 32211 29497547
Lower respiratory tract infection 14.89 12.21 11 44758 26491 29503267
Tuberculosis of genitourinary system 14.84 12.21 4 44765 20 29529738
Unevaluable event 14.79 12.21 14 44755 29837 29499921
Ocular icterus 14.76 12.21 19 44750 2596 29527162
Hypovolaemic shock 14.68 12.21 30 44739 6042 29523716
Red blood cell sedimentation rate decreased 14.67 12.21 5 44764 61 29529697
Amnesia 14.64 12.21 8 44761 22635 29507123
Dermatitis exfoliative generalised 14.64 12.21 20 44749 2896 29526862
Glucose-6-phosphate dehydrogenase deficiency 14.61 12.21 6 44763 126 29529632
Hypercreatininaemia 14.57 12.21 9 44760 460 29529298
Antibiotic level below therapeutic 14.45 12.21 5 44764 64 29529694
Vitamin A deficiency 14.38 12.21 4 44765 23 29529735
Metastases to heart 14.31 12.21 6 44763 133 29529625
Contraindicated product administered 14.11 12.21 5 44764 18261 29511497
Coagulation factor V level decreased 14.10 12.21 7 44762 232 29529526
Erythema annulare 14.09 12.21 4 44765 25 29529733
Drug hypersensitivity 14.09 12.21 162 44607 68244 29461514
Irritability 14.08 12.21 8 44761 22144 29507614
Dermatitis bullous 14.07 12.21 29 44740 5877 29523881
Pneumococcal infection 13.98 12.21 8 44761 355 29529403
Generalised bullous fixed drug eruption 13.95 12.21 3 44766 4 29529754
White blood cell count decreased 13.82 12.21 72 44697 83290 29446468
SJS-TEN overlap 13.75 12.21 7 44762 245 29529513
Bronchial haemorrhage 13.73 12.21 10 44759 673 29529085
Cholecystitis acute 13.72 12.21 27 44742 5292 29524466
Meningitis candida 13.66 12.21 5 44764 76 29529682
Psychotic disorder 13.44 12.21 7 44762 20347 29509411
COVID-19 treatment 13.42 12.21 7 44762 258 29529500
Asthma 13.40 12.21 19 44750 33830 29495928
Hypocoagulable state 13.36 12.21 11 44758 887 29528871
Urticarial vasculitis 13.35 12.21 4 44765 31 29529727
Face oedema 13.32 12.21 40 44729 10243 29519515
Palmar-plantar erythrodysaesthesia syndrome 13.32 12.21 3 44766 14756 29515002
Distal intestinal obstruction syndrome 13.32 12.21 7 44762 262 29529496
Ototoxicity 13.24 12.21 14 44755 1551 29528207
Mechanical urticaria 13.21 12.21 5 44764 84 29529674
Listeriosis 13.15 12.21 11 44758 907 29528851
Polycystic liver disease 13.03 12.21 4 44765 34 29529724
Haemodynamic instability 13.02 12.21 34 44735 8039 29521719
Dependence on oxygen therapy 12.95 12.21 6 44763 170 29529588
Altered state of consciousness 12.91 12.21 62 44707 19827 29509931
Neoplasm progression 12.90 12.21 6 44763 18606 29511152
Hyperglycaemia 12.84 12.21 20 44749 34267 29495491
Ureteric obstruction 12.79 12.21 12 44757 1151 29528607
Influenza like illness 12.69 12.21 11 44758 24459 29505299
Dry skin 12.68 12.21 10 44759 23297 29506461
Renal tubular necrosis 12.66 12.21 49 44720 14266 29515492
Haematuria traumatic 12.55 12.21 6 44763 183 29529575
Influenza 12.53 12.21 28 44741 41853 29487905
Hyperthermia 12.52 12.21 37 44732 9393 29520365
Blood cholesterol increased 12.51 12.21 4 44765 15591 29514167
Fistula discharge 12.47 12.21 8 44761 437 29529321
Rash erythematous 12.43 12.21 65 44704 21497 29508261
Leukopenia 12.40 12.21 133 44636 55070 29474688
Local anaesthetic systemic toxicity 12.37 12.21 6 44763 189 29529569
Haemorrhoids thrombosed 12.37 12.21 6 44763 189 29529569
Cardiac arrest 12.35 12.21 190 44579 85401 29444357
Fibrous dysplasia of bone 12.34 12.21 3 44766 9 29529749
Cryptococcosis 12.33 12.21 15 44754 1937 29527821
Cholestatic liver injury 12.31 12.21 14 44755 1683 29528075
PO2 decreased 12.25 12.21 13 44756 1446 29528312
Viral pharyngitis 12.22 12.21 5 44764 104 29529654

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 949.45 11.11 676 79876 53541 64364639
Off label use 603.54 11.11 1943 78609 630863 63787317
Pseudocholelithiasis 517.55 11.11 91 80461 0 64418180
Acute kidney injury 426.38 11.11 1379 79173 447861 63970319
Acute generalised exanthematous pustulosis 421.29 11.11 246 80306 13812 64404368
Toxic epidermal necrolysis 402.07 11.11 349 80203 36817 64381363
Postrenal failure 394.58 11.11 100 80452 474 64417706
Rash maculo-papular 385.18 11.11 378 80174 46648 64371532
Jarisch-Herxheimer reaction 362.52 11.11 97 80455 590 64417590
Eosinophilia 334.27 11.11 318 80234 37758 64380422
Fatigue 321.35 11.11 279 80273 748451 63669729
Multiple organ dysfunction syndrome 318.24 11.11 503 80049 100910 64317270
Cholelithiasis 283.39 11.11 316 80236 45190 64372990
Cholestasis 276.70 11.11 310 80242 44562 64373618
Completed suicide 259.75 11.11 4 80548 224410 64193770
Hepatitis 255.90 11.11 300 80252 45282 64372898
Agranulocytosis 249.32 11.11 272 80280 37957 64380223
Pyrexia 221.77 11.11 1320 79232 557324 63860856
Pain 219.64 11.11 221 80331 553290 63864890
Haemolytic anaemia 215.73 11.11 171 80381 15882 64402298
Anaphylactic shock 206.89 11.11 221 80331 30107 64388073
Joint swelling 202.70 11.11 18 80534 215364 64202816
Hepatocellular injury 201.35 11.11 265 80287 44970 64373210
Septic shock 197.03 11.11 418 80134 105019 64313161
Clostridium difficile colitis 195.71 11.11 204 80348 27019 64391161
Electrocardiogram QT prolonged 178.32 11.11 340 80212 79108 64339072
Factor V inhibition 172.38 11.11 47 80505 310 64417870
Rheumatoid arthritis 165.21 11.11 10 80542 164284 64253896
Fall 163.35 11.11 168 80384 416658 64001522
Appendicolith 157.64 11.11 80 80472 3389 64414791
Drug-induced liver injury 155.82 11.11 241 80311 47402 64370778
Arthralgia 155.11 11.11 195 80357 442065 63976115
Toxic encephalopathy 150.32 11.11 113 80439 9702 64408478
Hypertransaminasaemia 150.04 11.11 100 80452 7091 64411089
Drug intolerance 145.40 11.11 29 80523 187963 64230217
Weight increased 145.33 11.11 43 80509 213305 64204875
Product dose omission issue 144.58 11.11 33 80519 194714 64223466
Long QT syndrome 143.65 11.11 86 80466 5053 64413127
Tubulointerstitial nephritis 143.64 11.11 185 80367 30724 64387456
Dizziness 140.32 11.11 200 80352 429963 63988217
Drug interaction 140.27 11.11 851 79701 361232 64056948
Respiratory failure 137.16 11.11 478 80074 160705 64257475
Headache 134.74 11.11 288 80264 529179 63889001
Stevens-Johnson syndrome 134.73 11.11 189 80363 34060 64384120
Arthropathy 132.68 11.11 4 80548 120963 64297217
Bronchopulmonary aspergillosis 130.02 11.11 139 80413 18946 64399234
Abdominal discomfort 129.28 11.11 34 80518 182288 64235892
Pathogen resistance 118.17 11.11 109 80443 12434 64405746
Alopecia 117.27 11.11 31 80521 165659 64252521
Pain in extremity 115.43 11.11 125 80427 302960 64115220
Cardiogenic shock 113.04 11.11 169 80383 32258 64385922
Death 112.67 11.11 275 80277 482430 63935750
Nasopharyngitis 112.53 11.11 52 80500 196021 64222159
Acute respiratory distress syndrome 110.94 11.11 185 80367 38750 64379430
Synovitis 109.68 11.11 3 80549 99087 64319093
Therapeutic product effect decreased 107.50 11.11 10 80542 115341 64302839
Thrombocytopenia 107.06 11.11 557 79995 223244 64194936
Ureterolithiasis 106.54 11.11 60 80492 3141 64415039
Drug abuse 105.35 11.11 19 80533 132355 64285825
Hydronephrosis 103.57 11.11 107 80445 14018 64404162
Transaminases increased 102.68 11.11 193 80359 44401 64373779
Insomnia 102.37 11.11 60 80492 197776 64220404
Haemolysis 102.20 11.11 95 80457 10944 64407236
Leukocytosis 101.80 11.11 175 80377 37565 64380615
Peripheral swelling 100.59 11.11 69 80483 209084 64209096
Hepatitis cholestatic 99.99 11.11 98 80454 12057 64406123
Pseudomembranous colitis 99.29 11.11 67 80485 4849 64413331
Anaphylactic reaction 99.16 11.11 246 80306 68418 64349762
Depression 98.56 11.11 53 80499 183238 64234942
Immune reconstitution inflammatory syndrome 97.88 11.11 98 80454 12372 64405808
Sepsis 90.68 11.11 544 80008 229797 64188383
Contusion 89.30 11.11 17 80535 113948 64304232
Clostridium difficile infection 87.63 11.11 160 80392 36003 64382177
Premature delivery 87.52 11.11 112 80440 18477 64399703
Appendicitis 87.48 11.11 96 80456 13473 64404707
Alanine aminotransferase increased 85.32 11.11 372 80180 138659 64279521
Contraindicated product administered 84.67 11.11 16 80536 107813 64310367
Myocardial infarction 83.38 11.11 52 80500 165769 64252411
Clostridium test positive 82.91 11.11 56 80496 4059 64414121
Injection site pain 80.43 11.11 20 80532 111388 64306792
Choreoathetosis 79.56 11.11 38 80514 1409 64416771
Neutropenia 78.95 11.11 541 80011 239083 64179097
Drug resistance 78.43 11.11 150 80402 34952 64383228
Tachypnoea 78.03 11.11 128 80424 26443 64391737
Malaise 76.61 11.11 247 80305 396000 64022180
Toxicity to various agents 76.42 11.11 218 80334 363295 64054885
Cross sensitivity reaction 75.54 11.11 49 80503 3318 64414862
Encephalopathy 73.88 11.11 200 80352 58619 64359561
Status epilepticus 71.39 11.11 110 80442 21553 64396627
Product use in unapproved indication 70.02 11.11 418 80134 176200 64241980
Swelling 69.17 11.11 59 80493 160159 64258021
Hypoxia 68.57 11.11 254 80298 87895 64330285
Erythema 67.42 11.11 432 80120 186638 64231542
Drug ineffective for unapproved indication 67.06 11.11 131 80421 31002 64387178
Nocardiosis 66.67 11.11 52 80500 4715 64413465
Haemophagocytic lymphohistiocytosis 66.03 11.11 95 80457 17514 64400666
Disseminated intravascular coagulation 65.93 11.11 133 80419 32215 64385965
Pneumococcal infection 65.63 11.11 28 80524 793 64417387
Rash morbilliform 65.31 11.11 53 80499 5088 64413092
Anuria 64.90 11.11 98 80454 18866 64399314
Muscle spasms 64.53 11.11 49 80503 140974 64277206
Torsade de pointes 64.12 11.11 93 80459 17270 64400910
Sinusitis 63.89 11.11 53 80499 145875 64272305
Gait disturbance 63.27 11.11 73 80479 172082 64246098
Wound 62.99 11.11 10 80542 76467 64341713
Glossodynia 61.92 11.11 5 80547 64691 64353489
Brain abscess 61.51 11.11 47 80505 4134 64414046
Encephalitis 61.17 11.11 77 80475 12494 64405686
Klebsiella infection 60.92 11.11 79 80473 13202 64404978
Urticaria 59.24 11.11 350 80202 146967 64271213
Altered state of consciousness 58.12 11.11 139 80413 37763 64380417
Intentional overdose 57.87 11.11 20 80532 89924 64328256
Anxiety 57.63 11.11 103 80449 202546 64215634
Pleocytosis 57.62 11.11 28 80524 1079 64417101
Lower respiratory tract infection 57.58 11.11 23 80529 94591 64323589
Cardiac arrest 57.49 11.11 359 80193 153705 64264475
Pemphigus 57.25 11.11 5 80547 60696 64357484
Myasthenia gravis crisis 57.25 11.11 26 80526 858 64417322
Respiratory distress 56.98 11.11 169 80383 52162 64366018
Enterococcal infection 56.73 11.11 78 80474 13788 64404392
Injection site erythema 56.66 11.11 10 80542 70790 64347390
Inflammatory marker increased 56.58 11.11 61 80491 8390 64409790
Exposure during pregnancy 56.43 11.11 219 80333 77456 64340724
Systemic lupus erythematosus 55.88 11.11 14 80538 77598 64340582
Toxic skin eruption 55.42 11.11 92 80460 19192 64398988
Mobility decreased 55.38 11.11 19 80533 85821 64332359
Nausea 55.11 11.11 673 79879 785127 63633053
Liver injury 53.92 11.11 117 80435 29815 64388365
Cholangitis 53.89 11.11 67 80485 10735 64407445
Dermatitis bullous 52.65 11.11 70 80482 11984 64406196
Blood pressure fluctuation 52.59 11.11 3 80549 51868 64366312
Discomfort 52.00 11.11 18 80534 80860 64337320
COVID-19 pneumonia 51.87 11.11 82 80470 16422 64401758
Linear IgA disease 51.75 11.11 36 80516 2738 64415442
Musculoskeletal stiffness 51.20 11.11 47 80505 123159 64295021
Ventricular fibrillation 50.90 11.11 100 80452 23760 64394420
Weight decreased 49.19 11.11 187 80365 285552 64132628
Enterobacter infection 48.85 11.11 39 80513 3657 64414523
Feeling abnormal 48.71 11.11 57 80495 133545 64284635
Bile duct stone 48.33 11.11 44 80508 4934 64413246
Stomatitis 47.73 11.11 40 80512 109565 64308615
Musculoskeletal pain 47.48 11.11 21 80531 81273 64336907
Hepatic function abnormal 47.26 11.11 182 80370 64131 64354049
Neurotoxicity 46.96 11.11 105 80447 27299 64390881
Dermatitis exfoliative 46.58 11.11 61 80491 10291 64407889
Cyanosis 46.23 11.11 92 80460 22063 64396117
Blood pressure increased 46.15 11.11 91 80461 172461 64245719
Aspartate aminotransferase increased 45.85 11.11 281 80271 119507 64298673
Balance disorder 45.48 11.11 24 80528 83902 64334278
Oliguria 45.22 11.11 72 80480 14504 64403676
Jaundice 44.82 11.11 148 80404 48364 64369816
Trichosporon infection 44.74 11.11 22 80530 870 64417310
Hospitalisation 44.60 11.11 19 80533 75188 64342992
Hypoaesthesia 43.93 11.11 66 80486 139042 64279138
Migraine 43.80 11.11 12 80540 62665 64355515
Hypertension 43.76 11.11 171 80381 259090 64159090
Injection site reaction 43.58 11.11 4 80548 46660 64371520
Nosocomial infection 42.88 11.11 31 80521 2506 64415674
Abdominal pain upper 42.87 11.11 97 80455 174933 64243247
Fixed eruption 42.59 11.11 29 80523 2130 64416050
Symmetrical drug-related intertriginous and flexural exanthema 42.55 11.11 19 80533 602 64417578
Blood cholesterol increased 42.48 11.11 6 80546 50060 64368120
Inappropriate schedule of product administration 42.29 11.11 32 80520 92254 64325926
Back pain 41.59 11.11 166 80386 250005 64168175
Acute respiratory failure 41.46 11.11 147 80405 49787 64368393
Tachycardia 41.34 11.11 324 80228 149255 64268925
Psoriasis 41.12 11.11 19 80533 71684 64346496
Osteoarthritis 40.88 11.11 14 80538 63322 64354858
Endocarditis 40.26 11.11 54 80498 9324 64408856
Hypofibrinogenaemia 40.19 11.11 26 80526 1752 64416428
Renal failure 39.93 11.11 374 80178 181314 64236866
Condition aggravated 39.92 11.11 670 79882 371756 64046424
Dry mouth 39.62 11.11 13 80539 60405 64357775
Infusion related reaction 39.59 11.11 92 80460 164375 64253805
Acinetobacter infection 39.51 11.11 29 80523 2400 64415780
Cataract 39.40 11.11 8 80544 51254 64366926
Gastrooesophageal reflux disease 39.18 11.11 28 80524 83115 64335065
Pruritus 39.15 11.11 577 79975 311823 64106357
Leukopenia 39.05 11.11 238 80314 101004 64317176
Pancytopenia 38.82 11.11 309 80243 143000 64275180
Hepatomegaly 38.76 11.11 73 80479 16809 64401371
Rash 38.76 11.11 795 79757 457754 63960426
Hepatitis acute 38.64 11.11 64 80488 13325 64404855
Liver function test increased 38.57 11.11 105 80447 30865 64387315
Shock 38.35 11.11 120 80432 38120 64380060
Erythema nodosum 38.11 11.11 35 80517 3969 64414211
Influenza B virus test positive 38.02 11.11 15 80537 346 64417834
Renal papillary necrosis 37.90 11.11 15 80537 349 64417831
Wrong technique in product usage process 37.60 11.11 17 80535 64957 64353223
Suicidal ideation 37.60 11.11 18 80534 66524 64351656
Cardiac failure congestive 37.44 11.11 66 80486 130514 64287666
Haemodynamic instability 37.42 11.11 67 80485 14845 64403335
Hepatitis toxic 37.17 11.11 36 80516 4364 64413816
Coagulation factor decreased 37.12 11.11 12 80540 151 64418029
Cholecystitis 36.79 11.11 78 80474 19558 64398622
Splenomegaly 36.78 11.11 74 80478 17887 64400293
Blood glucose increased 36.65 11.11 41 80511 98032 64320148
Morganella infection 36.61 11.11 20 80532 986 64417194
Alcohol intolerance 36.61 11.11 15 80537 383 64417797
Bronchopleural fistula 36.55 11.11 17 80535 593 64417587
Arthritis 35.99 11.11 31 80521 83783 64334397
Ill-defined disorder 35.74 11.11 6 80546 44046 64374134
Disseminated cryptococcosis 35.63 11.11 23 80529 1544 64416636
Metabolic acidosis 35.51 11.11 179 80373 70779 64347401
Stenotrophomonas infection 35.47 11.11 30 80522 3050 64415130
Escherichia infection 35.34 11.11 66 80486 15102 64403078
Acute hepatic failure 35.02 11.11 91 80461 26021 64392159
Drug eruption 34.96 11.11 112 80440 36024 64382156
Renal tubular necrosis 34.88 11.11 82 80470 22028 64396152
Procalcitonin increased 34.46 11.11 27 80525 2464 64415716
Ascites 34.33 11.11 161 80391 61840 64356340
Mucormycosis 34.19 11.11 44 80508 7297 64410883
Cryptococcal meningoencephalitis 34.03 11.11 12 80540 200 64417980
Kounis syndrome 33.89 11.11 29 80523 2996 64415184
SJS-TEN overlap 33.87 11.11 15 80537 466 64417714
Hepatic cytolysis 33.82 11.11 62 80490 13987 64404193
Erythema multiforme 33.73 11.11 66 80486 15635 64402545
Palpitations 33.54 11.11 49 80503 104439 64313741
Vision blurred 33.49 11.11 38 80514 90278 64327902
Ureteral disorder 33.17 11.11 15 80537 490 64417690
Memory impairment 32.93 11.11 35 80517 85647 64332533
Type IV hypersensitivity reaction 32.74 11.11 30 80522 3392 64414788
Cerebrovascular accident 32.28 11.11 78 80474 137505 64280675
Hypercreatininaemia 31.88 11.11 17 80535 798 64417382
Candida infection 31.88 11.11 99 80453 31320 64386860
Coronary artery disease 31.69 11.11 18 80534 60415 64357765
Dermatitis exfoliative generalised 31.63 11.11 38 80514 5878 64412302
No adverse event 30.86 11.11 92 80460 28469 64389711
Alveolitis 30.80 11.11 30 80522 3662 64414518
Autoimmune haemolytic anaemia 30.76 11.11 41 80511 7035 64411145
Orthostatic hypotension 30.74 11.11 10 80542 46728 64371452
Intentional product misuse 30.72 11.11 27 80525 72268 64345912
Injection site swelling 30.67 11.11 7 80545 41346 64376834
Multiple sclerosis relapse 30.43 11.11 7 80545 41128 64377052
Unresponsive to stimuli 30.24 11.11 134 80418 50259 64367921
Pyuria 30.23 11.11 23 80529 2010 64416170
Gamma-glutamyltransferase increased 29.87 11.11 130 80422 48380 64369800
Chest pain 29.65 11.11 173 80379 235807 64182373
Dyspepsia 29.55 11.11 34 80518 80278 64337902
Helicobacter infection 29.46 11.11 6 80546 38356 64379824
Malignant mesenteric neoplasm 29.31 11.11 8 80544 53 64418127
Cholestatic liver injury 29.03 11.11 29 80523 3650 64414530
Rash erythematous 28.94 11.11 129 80423 48504 64369676
Injection site pruritus 28.87 11.11 6 80546 37820 64380360
Drug effective for unapproved indication 28.84 11.11 29 80523 3679 64414501
CSF measles antibody positive 28.81 11.11 8 80544 57 64418123
Herpes zoster 28.62 11.11 34 80518 79153 64339027
Anti factor V antibody 28.43 11.11 5 80547 0 64418180
Rubella antibody positive 28.33 11.11 8 80544 61 64418119
Organic brain syndrome 28.18 11.11 13 80539 445 64417735
Fluid retention 28.17 11.11 20 80532 59586 64358594
Portal fibrosis 27.96 11.11 14 80538 576 64417604
Type I hypersensitivity 27.88 11.11 28 80524 3546 64414634
Muscle abscess 27.63 11.11 16 80536 883 64417297
Influenza like illness 27.50 11.11 22 80530 61680 64356500
Aspergillus infection 27.22 11.11 62 80490 16317 64401863
Asthenia 27.14 11.11 374 80178 427670 63990510
Pericarditis 26.98 11.11 23 80529 62493 64355687
Nasal congestion 26.93 11.11 21 80531 59637 64358543
Angioedema 26.86 11.11 150 80402 61671 64356509
International normalised ratio increased 26.76 11.11 180 80372 78987 64339193
Janeway lesion 26.62 11.11 6 80546 15 64418165
Fibromyalgia 26.59 11.11 6 80546 35725 64382455
Flank pain 26.59 11.11 61 80491 16128 64402052
Hepatosplenomegaly 26.43 11.11 33 80519 5310 64412870
Hyperferritinaemia 26.40 11.11 13 80539 516 64417664
Crystalluria 25.99 11.11 15 80537 823 64417357
Diarrhoea 25.95 11.11 696 79856 722008 63696172
Leukaemoid reaction 25.80 11.11 11 80541 311 64417869
Systemic inflammatory response syndrome 25.70 11.11 46 80506 10189 64407991
Bacterial pericarditis 25.69 11.11 7 80545 46 64418134
COVID-19 treatment 25.37 11.11 12 80540 435 64417745
Peritoneal dialysis 25.26 11.11 14 80538 710 64417470
Loss of personal independence in daily activities 25.25 11.11 32 80520 72422 64345758
Type 2 diabetes mellitus 24.75 11.11 6 80546 34014 64384166
Localised infection 24.71 11.11 4 80548 30157 64388023
Ureteric obstruction 24.68 11.11 22 80530 2400 64415780
Folliculitis 24.61 11.11 4 80548 30073 64388107
Otitis media acute 24.58 11.11 16 80536 1090 64417090
Dry skin 24.40 11.11 17 80535 51144 64367036
Intervertebral discitis 24.36 11.11 27 80525 3830 64414350
Septic pulmonary embolism 24.11 11.11 6 80546 26 64418154
Jejunal ulcer perforation 24.10 11.11 8 80544 110 64418070
Suicide attempt 24.08 11.11 32 80520 70975 64347205
Purpura 24.05 11.11 61 80491 17185 64400995
Nervousness 24.03 11.11 4 80548 29552 64388628
Therapeutic product effect incomplete 24.01 11.11 59 80493 103423 64314757
Psoriatic arthropathy 24.00 11.11 12 80540 43269 64374911
Coagulopathy 23.99 11.11 91 80461 31829 64386351
Laryngeal stenosis 23.85 11.11 14 80538 793 64417387
Interleukin-2 receptor increased 23.82 11.11 9 80543 184 64417996
Hyperthermia 23.80 11.11 57 80495 15493 64402687
Hepatitis fulminant 23.74 11.11 34 80518 6240 64411940
Gastric disorder 23.63 11.11 4 80548 29193 64388987
Oropharyngeal pain 23.63 11.11 47 80505 88820 64329360
Visual impairment 23.51 11.11 35 80517 74042 64344138
Cholecystitis acute 23.49 11.11 47 80505 11313 64406867
Blood alkaline phosphatase increased 23.43 11.11 135 80417 56144 64362036
Transient ischaemic attack 23.40 11.11 13 80539 44169 64374011
Adverse event 23.37 11.11 10 80542 39479 64378701
Sphincter of Oddi dysfunction 23.33 11.11 11 80541 396 64417784
Meningitis bacterial 23.32 11.11 21 80531 2322 64415858
Calculus urinary 23.28 11.11 19 80533 1838 64416342
COVID-19 23.16 11.11 150 80402 64990 64353190
Pneumonia bacterial 22.89 11.11 55 80497 14980 64403200
Blood brain barrier defect 22.87 11.11 8 80544 130 64418050
Procalcitonin abnormal 22.75 11.11 10 80542 305 64417875
Pelvic inflammatory disease 22.71 11.11 16 80536 1242 64416938
Neck pain 22.69 11.11 26 80526 61507 64356673
Hyperbilirubinaemia 22.62 11.11 68 80484 21137 64397043
Cholangitis acute 22.59 11.11 16 80536 1252 64416928
Product use issue 22.54 11.11 105 80447 151610 64266570
Blood creatinine increased 22.49 11.11 264 80288 135518 64282662
Lip oedema 22.46 11.11 30 80522 5159 64413021
Normocytic anaemia 22.42 11.11 24 80528 3275 64414905
Face oedema 22.38 11.11 75 80477 24686 64393494
Eastern Cooperative Oncology Group performance status 22.35 11.11 6 80546 37 64418143
Sleep apnoea syndrome 22.22 11.11 5 80547 29827 64388353
Hypoalbuminaemia 22.08 11.11 60 80492 17614 64400566
Cerebral cyst 22.02 11.11 10 80542 330 64417850
Weber tuning fork test abnormal 21.96 11.11 7 80545 84 64418096
Strongyloidiasis 21.92 11.11 23 80529 3067 64415113
Maternal exposure during pregnancy 21.86 11.11 199 80353 95685 64322495
Fibrin D dimer increased 21.79 11.11 34 80518 6731 64411449
Pulmonary physical examination abnormal 21.78 11.11 5 80547 14 64418166
Gastroenteritis clostridial 21.63 11.11 13 80539 769 64417411
Factor V deficiency 21.59 11.11 7 80545 89 64418091
Lymphadenopathy 21.44 11.11 115 80437 46571 64371609
Corynebacterium infection 21.44 11.11 14 80538 959 64417221
Basal cell carcinoma 21.36 11.11 6 80546 30832 64387348
Omental necrosis 21.34 11.11 6 80546 45 64418135
Acquired haemophilia 21.21 11.11 17 80535 1603 64416577
Hyperlactacidaemia 20.95 11.11 28 80524 4816 64413364
Gastrointestinal disorder 20.92 11.11 51 80501 89658 64328522
Osteonecrosis of jaw 20.68 11.11 12 80540 39813 64378367
Neutrophilia 20.67 11.11 33 80519 6661 64411519
Vitamin K deficiency 20.65 11.11 12 80540 667 64417513
Diabetes mellitus 20.53 11.11 32 80520 66442 64351738
Surgery 20.48 11.11 5 80547 28208 64389972
Antinuclear antibody negative 20.41 11.11 5 80547 20 64418160
Depressed mood 20.40 11.11 13 80539 40999 64377181
Neoplasm progression 20.36 11.11 13 80539 40951 64377229
Serum sickness-like reaction 20.20 11.11 11 80541 539 64417641
Angina pectoris 20.18 11.11 16 80536 45065 64373115
Drug ineffective 20.13 11.11 1260 79292 838987 63579193
Vascular purpura 19.90 11.11 20 80532 2536 64415644
CSF protein increased 19.82 11.11 14 80538 1091 64417089
Pyelonephritis acute 19.69 11.11 28 80524 5106 64413074
Liver transplant failure 19.67 11.11 7 80545 120 64418060
Device related sepsis 19.60 11.11 28 80524 5127 64413053
Encephalitis brain stem 19.50 11.11 8 80544 205 64417975
Neuropathy peripheral 19.49 11.11 78 80474 117447 64300733
Nephropathy toxic 19.48 11.11 57 80495 17457 64400723
Bacteriuria 19.41 11.11 13 80539 929 64417251
Hepatitis infectious mononucleosis 19.25 11.11 7 80545 128 64418052
Hypocoagulable state 19.22 11.11 17 80535 1836 64416344
Sleep disorder 19.16 11.11 28 80524 59681 64358499
Iris transillumination defect 19.10 11.11 7 80545 131 64418049
Antibiotic associated colitis 19.09 11.11 4 80548 6 64418174
Thunderclap headache 19.04 11.11 8 80544 218 64417962
Bronchospasm 19.01 11.11 65 80487 21617 64396563
Joint injury 18.89 11.11 3 80549 22944 64395236
Pain in jaw 18.84 11.11 14 80538 40741 64377439
Infective chondritis 18.74 11.11 5 80547 30 64418150
Henoch-Schonlein purpura 18.54 11.11 18 80534 2188 64415992
Megacolon 18.48 11.11 21 80531 3061 64415119
Relapsing fever 18.42 11.11 9 80543 351 64417829
Dysgeusia 18.32 11.11 19 80533 47028 64371152
Tooth disorder 18.28 11.11 3 80549 22399 64395781
Sedation 18.21 11.11 15 80537 41447 64376733
Flatulence 18.17 11.11 11 80541 35655 64382525
Tracheobronchitis 18.10 11.11 16 80536 1726 64416454
Pyelonephritis 18.07 11.11 55 80497 17211 64400969
Metastases to stomach 18.02 11.11 8 80544 250 64417930
Hypokalaemia 18.01 11.11 232 80320 121671 64296509
Impaired healing 17.84 11.11 30 80522 60443 64357737
Pneumococcal sepsis 17.75 11.11 14 80538 1290 64416890
Postpartum sepsis 17.75 11.11 4 80548 10 64418170
Dry eye 17.74 11.11 7 80545 29012 64389168
Hyperamylasaemia 17.65 11.11 12 80540 879 64417301
Eosinophilic pneumonia 17.61 11.11 25 80527 4552 64413628
Lymphopenia 17.54 11.11 71 80481 25586 64392594
Osteomyelitis fungal 17.53 11.11 8 80544 267 64417913
Influenza 17.48 11.11 71 80481 106460 64311720
Haemostasis 17.45 11.11 8 80544 270 64417910
Meningism 17.42 11.11 10 80542 543 64417637
Thrombosis 17.40 11.11 39 80513 70603 64347577
Veillonella infection 17.39 11.11 5 80547 41 64418139
Hyponatraemia 17.38 11.11 271 80281 148068 64270112
Drug dependence 17.35 11.11 10 80542 33302 64384878
Dyspnoea 17.31 11.11 728 79824 717946 63700234
Antimicrobial susceptibility test resistant 17.31 11.11 8 80544 275 64417905
Pneumonia necrotising 17.27 11.11 12 80540 911 64417269
Dyspnoea exertional 17.13 11.11 42 80510 73688 64344492
Hip arthroplasty 17.11 11.11 3 80549 21348 64396832
Renal impairment 17.11 11.11 250 80302 134767 64283413
Macule 17.11 11.11 18 80534 2408 64415772
Blood pressure systolic increased 17.06 11.11 22 80530 49431 64368749
Red blood cell agglutination 17.06 11.11 3 80549 0 64418180
Hyperpyrexia 17.03 11.11 26 80526 5051 64413129
Intracranial pressure increased 17.02 11.11 31 80521 6958 64411222
Head injury 16.91 11.11 10 80542 32832 64385348
Pancreatitis acute 16.67 11.11 101 80451 42754 64375426
Decreased appetite 16.66 11.11 249 80303 281040 64137140
Bone pain 16.58 11.11 21 80531 47551 64370629
Hypersensitivity vasculitis 16.48 11.11 30 80522 6731 64411449
Carotid artery insufficiency 16.33 11.11 4 80548 16 64418164
Guillain-Barre syndrome 16.28 11.11 32 80520 7603 64410577
Obesity 16.24 11.11 3 80549 20559 64397621
Liver disorder 16.09 11.11 118 80434 53233 64364947
Syncope 16.05 11.11 123 80429 157512 64260668
Partial seizures 16.04 11.11 31 80521 7276 64410904
Joint stiffness 16.02 11.11 9 80543 30395 64387785
Overdose 16.02 11.11 125 80427 159441 64258739
Meningitis aseptic 16.01 11.11 27 80525 5703 64412477
Hypertriglyceridaemia 16.01 11.11 40 80512 11165 64407015
Viral infection 15.96 11.11 13 80539 36127 64382053
Sciatica 15.91 11.11 3 80549 20261 64397919
Vanishing bile duct syndrome 15.87 11.11 13 80539 1264 64416916
Cerebellar syndrome 15.87 11.11 25 80527 4991 64413189
Abdominal wall haematoma 15.81 11.11 23 80529 4282 64413898
Pulmonary necrosis 15.74 11.11 9 80543 485 64417695
Dehydration 15.71 11.11 184 80368 216579 64201601
Myopathy toxic 15.65 11.11 11 80541 850 64417330
Heart rate decreased 15.62 11.11 28 80524 55039 64363141
Empyema 15.57 11.11 21 80531 3644 64414536
Ocular icterus 15.56 11.11 25 80527 5073 64413107
Somnolence 15.49 11.11 171 80381 203474 64214706
Ear pain 15.47 11.11 6 80546 25130 64393050
Delirium 15.46 11.11 143 80409 69051 64349129
Coronavirus infection 15.38 11.11 26 80526 5504 64412676
Endocarditis bacterial 15.30 11.11 13 80539 1330 64416850
Muscle injury 15.16 11.11 7 80545 26430 64391750
Amnesia 15.13 11.11 23 80529 48246 64369934
Accidental exposure to product 15.09 11.11 7 80545 26357 64391823
Normal newborn 15.08 11.11 26 80526 5591 64412589
Hypovolaemic shock 15.04 11.11 37 80515 10229 64407951
Blood fibrinogen increased 14.99 11.11 14 80538 1622 64416558
Diabetes insipidus 14.95 11.11 23 80529 4498 64413682
Respiratory acidosis 14.95 11.11 36 80516 9819 64408361
Central nervous system vasculitis 14.88 11.11 12 80540 1142 64417038
Red blood cell schistocytes present 14.84 11.11 9 80543 541 64417639
Hypotension 14.82 11.11 599 79953 380375 64037805
Haemodialysis 14.80 11.11 51 80501 17026 64401154
Laryngeal mass 14.79 11.11 5 80547 73 64418107
Multiple-drug resistance 14.78 11.11 28 80524 6474 64411706
Lung consolidation 14.75 11.11 31 80521 7727 64410453
Antibiotic level below therapeutic 14.73 11.11 5 80547 74 64418106
Brain herniation 14.69 11.11 28 80524 6505 64411675
Respiratory disorder 14.62 11.11 86 80466 36025 64382155
Injection site haemorrhage 14.60 11.11 6 80546 24272 64393908
Incorrect dose administered 14.60 11.11 34 80518 60731 64357449
Psychotic disorder 14.58 11.11 13 80539 34565 64383615
Endotracheal intubation 14.58 11.11 21 80531 3874 64414306
ADAMTS13 activity decreased 14.58 11.11 6 80546 155 64418025
Fungal peritonitis 14.47 11.11 11 80541 960 64417220
Pneumonia pneumococcal 14.46 11.11 19 80533 3215 64414965
Prothrombin time ratio decreased 14.34 11.11 10 80542 763 64417417
Tuberculosis of genitourinary system 14.34 11.11 4 80548 29 64418151
Haemorrhoids 14.33 11.11 6 80546 23995 64394185
Infective spondylitis 14.32 11.11 8 80544 412 64417768
Blood pressure diastolic decreased 14.27 11.11 5 80547 22296 64395884
Tubulointerstitial nephritis and uveitis syndrome 14.23 11.11 7 80545 277 64417903
Mixed liver injury 14.23 11.11 25 80527 5456 64412724
Rash macular 14.22 11.11 63 80489 23622 64394558
Metastases to bone 14.11 11.11 4 80548 20431 64397749
Septic embolus 14.11 11.11 14 80538 1748 64416432
Muscular weakness 14.10 11.11 97 80455 127241 64290939
Pneumonia staphylococcal 13.99 11.11 22 80530 4384 64413796
Bone marrow failure 13.86 11.11 105 80447 47847 64370333
Transverse sinus thrombosis 13.85 11.11 9 80543 611 64417569
Limb injury 13.83 11.11 6 80546 23499 64394681
Rash pustular 13.82 11.11 35 80517 9850 64408330
Lymphocyte transformation test positive 13.78 11.11 4 80548 34 64418146
Hemianopia 13.77 11.11 13 80539 1526 64416654
Post treatment Lyme disease syndrome 13.77 11.11 3 80549 6 64418174
Dry gangrene 13.73 11.11 10 80542 818 64417362
Pseudophaeochromocytoma 13.72 11.11 5 80547 92 64418088
Haematuria traumatic 13.62 11.11 6 80546 184 64417996
Foot fracture 13.61 11.11 3 80549 18154 64400026
Cardiac disorder 13.60 11.11 31 80521 55785 64362395
Cardiac valve abscess 13.58 11.11 4 80548 36 64418144
Staphylococcal infection 13.56 11.11 109 80443 50569 64367611
Dysstasia 13.55 11.11 6 80546 23209 64394971
Blood lactate dehydrogenase increased 13.54 11.11 79 80473 32999 64385181
Bacteraemia 13.54 11.11 68 80484 26843 64391337
Gait inability 13.46 11.11 20 80532 42348 64375832
Tetany 13.37 11.11 15 80537 2157 64416023
Pneumonia mycoplasmal 13.35 11.11 12 80540 1324 64416856
Encephalomalacia 13.34 11.11 11 80541 1080 64417100
POEMS syndrome 13.30 11.11 4 80548 39 64418141
Product substitution issue 13.29 11.11 3 80549 17858 64400322
Oral pain 13.29 11.11 9 80543 27484 64390696
Hypophagia 13.26 11.11 18 80534 39569 64378611
Meningitis 13.26 11.11 31 80521 8298 64409882
Eye pain 13.21 11.11 12 80540 31613 64386567
Palmar-plantar erythrodysaesthesia syndrome 13.19 11.11 10 80542 28809 64389371
Unevaluable event 13.16 11.11 27 80525 50462 64367718
Pollakiuria 13.12 11.11 12 80540 31518 64386662
Toxic shock syndrome 13.12 11.11 10 80542 876 64417304
Eosinophilic pneumonia acute 13.11 11.11 10 80542 877 64417303
Hyper IgE syndrome 13.10 11.11 8 80544 487 64417693
Dysmetria 13.02 11.11 10 80542 886 64417294
Anoxia 12.95 11.11 7 80545 338 64417842
Serum ferritin increased 12.92 11.11 31 80521 8437 64409743
Generalised bullous fixed drug eruption 12.91 11.11 3 80549 9 64418171
Haemorrhoids thrombosed 12.91 11.11 6 80546 209 64417971
Hepatic necrosis 12.91 11.11 31 80521 8442 64409738
Clostridial infection 12.84 11.11 23 80529 5096 64413084
Biliary dilatation 12.84 11.11 15 80537 2253 64415927
Foetal death 12.82 11.11 25 80527 5905 64412275
Gastrointestinal mucormycosis 12.81 11.11 7 80545 345 64417835
Epistaxis 12.81 11.11 71 80481 98060 64320120
Osteonecrosis 12.66 11.11 10 80542 28219 64389961
Histoplasmosis disseminated 12.64 11.11 14 80538 1984 64416196
Intravascular haemolysis 12.63 11.11 9 80543 711 64417469
Necrosis 12.56 11.11 30 80522 8141 64410039
Multiple sclerosis 12.55 11.11 4 80548 18937 64399243
Metastases to heart 12.52 11.11 6 80546 224 64417956
Chondrocalcinosis 12.52 11.11 9 80543 721 64417459
Haemoglobinuria 12.49 11.11 9 80543 724 64417456
Overlap syndrome 12.45 11.11 9 80543 727 64417453
Liver abscess 12.33 11.11 23 80529 5257 64412923
Petechiae 12.30 11.11 51 80501 18575 64399605
Bronchial obstruction 12.28 11.11 15 80537 2359 64415821
Neuralgic amyotrophy 12.28 11.11 6 80546 234 64417946
Sinus disorder 12.26 11.11 3 80549 16905 64401275
Ototoxicity 12.18 11.11 16 80536 2707 64415473
C-reactive protein increased 12.13 11.11 176 80376 94733 64323447
Wound haemorrhage 12.12 11.11 18 80534 3413 64414767
Streptococcal infection 12.08 11.11 28 80524 7451 64410729
Pulmonary function test 12.06 11.11 3 80549 13 64418167
Azotaemia 12.03 11.11 28 80524 7474 64410706
Drug hypersensitivity 11.96 11.11 385 80167 237430 64180750
Heart rate irregular 11.93 11.11 10 80542 27403 64390777
Subdural abscess 11.92 11.11 4 80548 57 64418123
Infection 11.88 11.11 161 80391 184719 64233461
Urine potassium increased 11.87 11.11 3 80549 14 64418166
Meningitis candida 11.87 11.11 5 80547 137 64418043
Bursitis 11.85 11.11 6 80546 21479 64396701
Asthma 11.84 11.11 70 80482 95155 64323025
Skin discolouration 11.84 11.11 16 80536 35239 64382941
CSF oligoclonal band present 11.81 11.11 5 80547 139 64418041
Dependence on oxygen therapy 11.79 11.11 7 80545 405 64417775
Tissue infiltration 11.78 11.11 8 80544 585 64417595
Conjunctival hyperaemia 11.74 11.11 19 80533 3880 64414300
Crying 11.73 11.11 53 80499 20037 64398143
Coagulation factor V level decreased 11.71 11.11 8 80544 591 64417589
Localised oedema 11.70 11.11 27 80525 7164 64411016
Haemoperitoneum 11.68 11.11 19 80533 3896 64414284
Vitamin A deficiency 11.61 11.11 4 80548 62 64418118
Skin test positive 11.60 11.11 10 80542 1043 64417137
Disturbance in attention 11.55 11.11 21 80531 41053 64377127
Periostosis 11.54 11.11 3 80549 16 64418164
Neisseria infection 11.49 11.11 4 80548 64 64418116
Allergy test positive 11.42 11.11 7 80545 429 64417751
Coagulation factor V level abnormal 11.39 11.11 3 80549 17 64418163
CD4 lymphocytes increased 11.39 11.11 6 80546 275 64417905
Panic attack 11.33 11.11 6 80546 20947 64397233
Faeces pale 11.33 11.11 15 80537 2556 64415624
Normochromic anaemia 11.33 11.11 7 80545 435 64417745
Glycosylated haemoglobin increased 11.32 11.11 3 80549 16016 64402164
Unmasking of previously unidentified disease 11.22 11.11 12 80540 1635 64416545
Cell death 11.19 11.11 19 80533 4035 64414145
Acidosis 11.19 11.11 48 80504 17747 64400433
Alpha 1 microglobulin increased 11.16 11.11 4 80548 70 64418110
Hepatic failure 11.15 11.11 112 80440 55282 64362898

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01DD04 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Third-generation cephalosporins
ATC J01DD54 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Third-generation cephalosporins
ATC J01DD63 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Third-generation cephalosporins
FDA CS M0003827 Cephalosporins
FDA EPC N0000175488 Cephalosporin Antibacterial
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:35625 beta-lactamase inhibitors
CHEBI has role CHEBI:36047 antibacterial drugs
CHEBI has role CHEBI:88188 allergenic drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Gonococcal meningitis indication 151004
Streptococcal meningitis indication 4510004 DOID:11574
Septicemia due to Escherichia coli indication 9323009
Bacterial septicemia indication 10001005 DOID:0040085
Staphylococcal meningitis indication 12166008
Gonorrhea indication 15628003 DOID:7551
Infection of skin AND/OR subcutaneous tissue indication 19824006
Acute gonococcal cervicitis indication 20943002 DOID:10615
Staphylococcal pneumonia indication 22754005
Streptococcal septicemia indication 29577008
Acute gonococcal urethritis indication 29864006
Pneumonia due to Streptococcus indication 34020007
Gonorrhea of rectum indication 42746002
Gonococcal infection of joint indication 44743006
Bacterial arthritis indication 48245008
Salmonella septicemia indication 49786009
Lower respiratory tract infection indication 50417007
Pneumococcal meningitis indication 51169003
Pneumonia due to Escherichia coli indication 51530003
Bacterial pneumonia indication 53084003 DOID:874
Klebsiella cystitis indication 60867007
Gonococcal endocarditis indication 61048000
Acute gonococcal endometritis indication 65295003 DOID:7527
Haemophilus influenzae pneumonia indication 70036007
Infection due to Escherichia coli indication 71057007
Bacterial infection due to Serratia indication 71120004
Rhinoscleroma indication 72409005 DOID:11336
Gonorrhea of pharynx indication 74372003
Endometritis indication 78623009 DOID:1002
Bacterial meningitis indication 95883001 DOID:9470
Infection of bone indication 111253001
Staphylococcal septicemia indication 111821004
Female genital tract infection indication 125585007
Infectious disease of abdomen indication 128070006
Infection due to Enterobacteriaceae indication 128945009
Bacterial infection due to Klebsiella pneumoniae indication 186435004
Meningococcal meningitis indication 192644005
Escherichia coli meningitis indication 192655005
Proteus pneumonia indication 195888009
Chancroid indication 266143009 DOID:13778
Escherichia coli urinary tract infection indication 301011002
Proteus urinary tract infection indication 301012009
Streptococcus pyogenes infection indication 302809008
Bacterial urinary infection indication 312124009
Infective otitis media indication 312218008
Infectious disorder of joint indication 363162000
Meningitis due to Klebsiella mobilis indication 420585007
Peptostreptococcus infection indication 135341000119101
Klebsiella Pneumoniae Osteomyelitis indication
Inflammatory Disease of Female Pelvic Organs indication
Proteus Mirabilis Osteomyelitis indication
Peptostreptococcus Peritonitis indication
Enterobacter Pneumonia indication
Proteus Joint Infection indication
E. Coli Peritonitis indication
Skin and Skin Structure Serratia Infection indication
Haemophilus Septic Arthritis indication
Prevention of Perioperative Infection indication
Haemophilus Influenzae Type B Infections indication
Adult Gonococcal Conjunctivitis indication
E. Coli Septic Arthritis indication
Haemophilus Septicemia indication
Disseminated Gonococcal Infection indication
Klebsiella Pneumoniae Peritonitis indication
H. Influenzae Meningitis indication
Prevention of Meningococcal Meningitis indication
Gram-Negative Aerobic Bacillary Pneumonia indication
Skin and Skin Structure Proteus Infection indication
Haemophilus Osteomyelitis indication
Haemophilus Parainfluenzae Pneumonia indication
Enterobacter Osteomyelitis indication
Streptococcal Joint Infection indication
Pelvic Inflammatory Disease with Neisseria Gonorrhea indication
Klebsiella Joint Infection indication
EnterobacterJoint Infection indication
Skin and Skin Structure Morganella Morganii Infection indication
Streptococcus Osteomyelitis indication
E. Coli Joint Infection indication
E. Coli Osteomyelitis indication
Pyrexia of unknown origin off-label use 7520000
Lyme disease off-label use 23502006 DOID:11729
Lyme arthritis off-label use 33937009
Pseudotuberculosis off-label use 36753006
Lyme carditis off-label use 77863005
Infection by Yersinia enterocolitica off-label use 80960004
Ventilator-acquired pneumonia off-label use 429271009
Lyme Disease of the Central Nervous System off-label use
Sexual Transmitted Disease Exposure from Sexual Assault off-label use
Disorder of gallbladder contraindication 39621005 DOID:0060262
Acute nephropathy contraindication 58574008
Hemolytic anemia contraindication 61261009 DOID:583
Disease of liver contraindication 235856003 DOID:409
Neonatal hyperbilirubinemia contraindication 281610001
Pseudomembranous enterocolitis contraindication 397683000




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.65 acidic
pKa2 4.17 acidic
pKa3 13.31 acidic
pKa4 3.29 Basic
pKa5 0.93 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D-amino-acid oxidase Enzyme IC50 5 CHEMBL
Alpha-synuclein Transporter Kd 6.28 CHEMBL
Peptidoglycan synthase FtsI Enzyme INHIBITOR IC50 6.14 WOMBAT-PK CHEMBL
Penicillin-binding protein 1A Enzyme INHIBITOR IC50 6.51 WOMBAT-PK CHEMBL
Penicillin-binding protein 1B Enzyme INHIBITOR IC50 5.74 WOMBAT-PK CHEMBL
Penicillin-binding protein 2 Enzyme INHIBITOR IC50 6.21 WOMBAT-PK CHEMBL

External reference:

IDSource
4019667 VUID
N0000147759 NUI
D00924 KEGG_DRUG
104376-79-6 SECONDARY_CAS_RN
203172 RXNORM
4017814 VANDF
4019667 VANDF
C0007561 UMLSCUI
CHEBI:29007 CHEBI
9F2 PDB_CHEM_ID
CHEMBL1200995 ChEMBL_ID
CHEMBL161 ChEMBL_ID
CHEMBL3183968 ChEMBL_ID
D002443 MESH_DESCRIPTOR_UI
DB01212 DRUGBANK_ID
5326 IUPHAR_LIGAND_ID
4923 INN_ID
75J73V1629 UNII
5479530 PUBCHEM_CID
1314 MMSL
4387 MMSL
69782 MMSL
d00052 MMSL
002734 NDDF
004849 NDDF
19841008 SNOMEDCT_US
33440000 SNOMEDCT_US
372670001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9678 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 26 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9768 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 23 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9856 INJECTION, POWDER, FOR SOLUTION 2 g INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9857 INJECTION, POWDER, FOR SOLUTION 1 g INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9858 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAMUSCULAR ANDA 24 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9859 INJECTION, POWDER, FOR SOLUTION 250 mg INTRAMUSCULAR ANDA 24 sections
CEFTRIAXONE AND DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0264-3153 INJECTION, SOLUTION 1 g INTRAVENOUS NDA 27 sections
CEFTRIAXONE AND DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0264-3155 INJECTION, SOLUTION 2 g INTRAVENOUS NDA 27 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0338-5002 INJECTION, SOLUTION 1 g INTRAVENOUS ANDA 23 sections
Ceftriaxone HUMAN PRESCRIPTION DRUG LABEL 1 0338-5003 INJECTION, SOLUTION 2 g INTRAVENOUS ANDA 23 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7332 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7332 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7332 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7332 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7333 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 21 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7333 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 21 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7333 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 21 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7333 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 21 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7334 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 25 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7334 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 25 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7334 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 25 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7334 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 25 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7335 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7335 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7335 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7335 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 24 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7336 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 21 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7336 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 21 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7336 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 21 sections
Ceftriaxone Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7336 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 21 sections