Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, cefalosporanic acid derivatives | 564 | 73384-59-5 |
Dose | Unit | Route |
---|---|---|
2 | g | P |
2 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 400 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 46 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 120.27 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 0 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.12 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.22 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.10 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 7.60 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 21, 1984 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug reaction with eosinophilia and systemic symptoms | 705.22 | 12.34 | 378 | 40513 | 28046 | 50536187 |
Toxic epidermal necrolysis | 374.14 | 12.34 | 225 | 40666 | 20767 | 50543466 |
Acute generalised exanthematous pustulosis | 352.52 | 12.34 | 163 | 40728 | 8775 | 50555458 |
Acute kidney injury | 328.69 | 12.34 | 628 | 40263 | 227430 | 50336803 |
Pseudocholelithiasis | 318.36 | 12.34 | 52 | 40839 | 0 | 50564233 |
Rash maculo-papular | 250.02 | 12.34 | 192 | 40699 | 26449 | 50537784 |
Eosinophilia | 230.94 | 12.34 | 159 | 40732 | 18493 | 50545740 |
Multiple organ dysfunction syndrome | 228.95 | 12.34 | 241 | 40650 | 50096 | 50514137 |
Fatigue | 207.54 | 12.34 | 162 | 40729 | 707439 | 49856794 |
Jarisch-Herxheimer reaction | 196.34 | 12.34 | 46 | 40845 | 249 | 50563984 |
Off label use | 183.07 | 12.34 | 812 | 40079 | 473614 | 50090619 |
Agranulocytosis | 168.06 | 12.34 | 139 | 40752 | 21282 | 50542951 |
Pain | 166.38 | 12.34 | 135 | 40756 | 578768 | 49985465 |
Joint swelling | 161.81 | 12.34 | 9 | 40882 | 245277 | 50318956 |
Pyrexia | 160.47 | 12.34 | 669 | 40222 | 379534 | 50184699 |
Cholestasis | 155.30 | 12.34 | 143 | 40748 | 25258 | 50538975 |
Hepatitis | 154.51 | 12.34 | 157 | 40734 | 31296 | 50532937 |
Stevens-Johnson syndrome | 153.90 | 12.34 | 133 | 40758 | 21619 | 50542614 |
Cholelithiasis | 148.55 | 12.34 | 168 | 40723 | 37805 | 50526428 |
Recalled product administered | 147.36 | 12.34 | 40 | 40851 | 422 | 50563811 |
Septic shock | 146.97 | 12.34 | 205 | 40686 | 56970 | 50507263 |
Drug interaction | 146.96 | 12.34 | 423 | 40468 | 199198 | 50365035 |
Clostridium difficile colitis | 138.91 | 12.34 | 115 | 40776 | 17627 | 50546606 |
Haemolytic anaemia | 138.65 | 12.34 | 89 | 40802 | 9203 | 50555030 |
Electrocardiogram QT prolonged | 137.80 | 12.34 | 189 | 40702 | 51697 | 50512536 |
Rheumatoid arthritis | 131.82 | 12.34 | 8 | 40883 | 202542 | 50361691 |
Factor V inhibition | 125.37 | 12.34 | 29 | 40862 | 147 | 50564086 |
Tubulointerstitial nephritis | 124.12 | 12.34 | 101 | 40790 | 15110 | 50549123 |
Drug intolerance | 122.90 | 12.34 | 16 | 40875 | 219088 | 50345145 |
Anaphylactic shock | 122.29 | 12.34 | 113 | 40778 | 20042 | 50544191 |
Alopecia | 121.64 | 12.34 | 25 | 40866 | 245022 | 50319211 |
Premature delivery | 121.50 | 12.34 | 121 | 40770 | 23542 | 50540691 |
Arthralgia | 120.07 | 12.34 | 107 | 40784 | 438595 | 50125638 |
Arthropathy | 113.53 | 12.34 | 3 | 40888 | 157903 | 50406330 |
Postrenal failure | 104.88 | 12.34 | 23 | 40868 | 87 | 50564146 |
Abdominal discomfort | 102.55 | 12.34 | 30 | 40861 | 231611 | 50332622 |
Hepatocellular injury | 101.81 | 12.34 | 115 | 40776 | 25832 | 50538401 |
Headache | 99.78 | 12.34 | 160 | 40731 | 506375 | 50057858 |
Leukocytosis | 93.61 | 12.34 | 103 | 40788 | 22476 | 50541757 |
Weight increased | 87.80 | 12.34 | 27 | 40864 | 201864 | 50362369 |
Hepatitis cholestatic | 87.35 | 12.34 | 57 | 40834 | 6060 | 50558173 |
Therapeutic product effect decreased | 86.62 | 12.34 | 6 | 40885 | 136044 | 50428189 |
Swelling | 85.33 | 12.34 | 28 | 40863 | 200844 | 50363389 |
Status epilepticus | 84.90 | 12.34 | 77 | 40814 | 13329 | 50550904 |
Fall | 84.19 | 12.34 | 88 | 40803 | 334844 | 50229389 |
Acute respiratory distress syndrome | 83.60 | 12.34 | 94 | 40797 | 21005 | 50543228 |
Product dose omission issue | 82.84 | 12.34 | 23 | 40868 | 183815 | 50380418 |
Drug-induced liver injury | 81.68 | 12.34 | 107 | 40784 | 27988 | 50536245 |
Pemphigus | 80.45 | 12.34 | 4 | 40887 | 120162 | 50444071 |
Pseudomembranous colitis | 80.27 | 12.34 | 41 | 40850 | 2744 | 50561489 |
Glossodynia | 80.17 | 12.34 | 3 | 40888 | 115566 | 50448667 |
Clostridium difficile infection | 78.84 | 12.34 | 100 | 40791 | 25339 | 50538894 |
Contraindicated product administered | 78.57 | 12.34 | 13 | 40878 | 148945 | 50415288 |
Thrombocytopenia | 78.30 | 12.34 | 254 | 40637 | 127419 | 50436814 |
Encephalopathy | 76.53 | 12.34 | 114 | 40777 | 33597 | 50530636 |
Respiratory failure | 75.61 | 12.34 | 202 | 40689 | 90979 | 50473254 |
Systemic lupus erythematosus | 74.78 | 12.34 | 12 | 40879 | 140610 | 50423623 |
Nasopharyngitis | 73.41 | 12.34 | 32 | 40859 | 192895 | 50371338 |
Exposure during pregnancy | 72.62 | 12.34 | 239 | 40652 | 120776 | 50443457 |
Peripheral swelling | 72.49 | 12.34 | 38 | 40853 | 205898 | 50358335 |
Altered state of consciousness | 70.88 | 12.34 | 88 | 40803 | 21822 | 50542411 |
Sepsis | 70.57 | 12.34 | 252 | 40639 | 132673 | 50431560 |
Enterococcal infection | 69.72 | 12.34 | 52 | 40839 | 6846 | 50557387 |
Long QT syndrome | 66.66 | 12.34 | 37 | 40854 | 2930 | 50561303 |
Cardiac arrest | 66.02 | 12.34 | 182 | 40709 | 83469 | 50480764 |
Haemophagocytic lymphohistiocytosis | 65.57 | 12.34 | 55 | 40836 | 8578 | 50555655 |
Erythema | 64.07 | 12.34 | 261 | 40630 | 146153 | 50418080 |
Transaminases increased | 63.02 | 12.34 | 94 | 40797 | 27730 | 50536503 |
Neutropenia | 62.57 | 12.34 | 261 | 40630 | 147704 | 50416529 |
Pain in extremity | 61.68 | 12.34 | 78 | 40813 | 272787 | 50291446 |
Dermatitis exfoliative | 61.66 | 12.34 | 43 | 40848 | 5099 | 50559134 |
Wound | 61.04 | 12.34 | 7 | 40884 | 105787 | 50458446 |
Choreoathetosis | 60.91 | 12.34 | 20 | 40871 | 421 | 50563812 |
Insomnia | 60.45 | 12.34 | 33 | 40858 | 174832 | 50389401 |
Linear IgA disease | 59.39 | 12.34 | 26 | 40865 | 1228 | 50563005 |
Bronchopulmonary aspergillosis | 58.97 | 12.34 | 49 | 40842 | 7543 | 50556690 |
Pneumococcal infection | 58.18 | 12.34 | 19 | 40872 | 393 | 50563840 |
Injection site pain | 57.85 | 12.34 | 10 | 40881 | 111014 | 50453219 |
Toxic encephalopathy | 56.69 | 12.34 | 42 | 40849 | 5473 | 50558760 |
Tachypnoea | 56.14 | 12.34 | 64 | 40827 | 14513 | 50549720 |
Dizziness | 56.06 | 12.34 | 123 | 40768 | 346246 | 50217987 |
Myasthenia gravis crisis | 55.22 | 12.34 | 18 | 40873 | 370 | 50563863 |
Hypoxia | 54.80 | 12.34 | 125 | 40766 | 50998 | 50513235 |
Acinetobacter infection | 53.07 | 12.34 | 25 | 40866 | 1402 | 50562831 |
Tachycardia | 52.80 | 12.34 | 189 | 40702 | 99574 | 50464659 |
Alveolitis | 52.59 | 12.34 | 30 | 40861 | 2504 | 50561729 |
Torsade de pointes | 52.57 | 12.34 | 56 | 40835 | 11779 | 50552454 |
Pericarditis | 51.47 | 12.34 | 3 | 40888 | 78686 | 50485547 |
Contusion | 50.57 | 12.34 | 14 | 40877 | 112169 | 50452064 |
Cholecystitis | 50.23 | 12.34 | 59 | 40832 | 13812 | 50550421 |
Metabolic acidosis | 49.70 | 12.34 | 102 | 40789 | 38723 | 50525510 |
Dermatitis bullous | 48.99 | 12.34 | 43 | 40848 | 7130 | 50557103 |
Influenza B virus test positive | 48.57 | 12.34 | 15 | 40876 | 257 | 50563976 |
Symmetrical drug-related intertriginous and flexural exanthema | 48.33 | 12.34 | 16 | 40875 | 346 | 50563887 |
Anaphylactic reaction | 48.10 | 12.34 | 123 | 40768 | 53932 | 50510301 |
No adverse event | 47.52 | 12.34 | 92 | 40799 | 33486 | 50530747 |
Rash morbilliform | 46.81 | 12.34 | 29 | 40862 | 2817 | 50561416 |
Musculoskeletal stiffness | 46.23 | 12.34 | 23 | 40868 | 128458 | 50435775 |
Low birth weight baby | 45.77 | 12.34 | 38 | 40853 | 5843 | 50558390 |
Discomfort | 44.44 | 12.34 | 16 | 40875 | 108364 | 50455869 |
Drug ineffective for unapproved indication | 44.10 | 12.34 | 69 | 40822 | 21212 | 50543021 |
Drug resistance | 42.78 | 12.34 | 64 | 40827 | 18925 | 50545308 |
Acute respiratory failure | 42.13 | 12.34 | 80 | 40811 | 28702 | 50535531 |
Urticaria | 41.71 | 12.34 | 211 | 40680 | 129350 | 50434883 |
Psoriasis | 41.25 | 12.34 | 4 | 40887 | 68996 | 50495237 |
Pancytopenia | 40.93 | 12.34 | 155 | 40736 | 83875 | 50480358 |
Depression | 40.88 | 12.34 | 44 | 40847 | 165379 | 50398854 |
Cholangitis | 40.75 | 12.34 | 32 | 40859 | 4547 | 50559686 |
Pathogen resistance | 40.66 | 12.34 | 35 | 40856 | 5654 | 50558579 |
Hypertransaminasaemia | 40.52 | 12.34 | 29 | 40862 | 3582 | 50560651 |
Gait disturbance | 40.39 | 12.34 | 37 | 40854 | 149968 | 50414265 |
Cross sensitivity reaction | 40.03 | 12.34 | 23 | 40868 | 1946 | 50562287 |
Nosocomial infection | 39.83 | 12.34 | 21 | 40870 | 1501 | 50562732 |
Weight decreased | 39.64 | 12.34 | 74 | 40817 | 221171 | 50343062 |
Renal failure | 38.88 | 12.34 | 180 | 40711 | 106453 | 50457780 |
Muscle spasms | 38.78 | 12.34 | 27 | 40864 | 125526 | 50438707 |
Pleocytosis | 37.97 | 12.34 | 15 | 40876 | 545 | 50563688 |
Pyuria | 37.84 | 12.34 | 21 | 40870 | 1662 | 50562571 |
Nausea | 37.61 | 12.34 | 377 | 40514 | 705021 | 49859212 |
Premature baby | 37.37 | 12.34 | 59 | 40832 | 18278 | 50545955 |
Haemolysis | 37.00 | 12.34 | 34 | 40857 | 5982 | 50558251 |
Injection site erythema | 36.39 | 12.34 | 8 | 40883 | 74928 | 50489305 |
Malaise | 35.57 | 12.34 | 145 | 40746 | 335387 | 50228846 |
Death | 35.51 | 12.34 | 139 | 40752 | 325240 | 50238993 |
Hydronephrosis | 35.46 | 12.34 | 39 | 40852 | 8502 | 50555731 |
Stenotrophomonas infection | 35.29 | 12.34 | 20 | 40871 | 1649 | 50562584 |
Arthritis | 35.21 | 12.34 | 13 | 40878 | 86708 | 50477525 |
Encephalitis | 34.70 | 12.34 | 36 | 40855 | 7344 | 50556889 |
Guillain-Barre syndrome | 34.67 | 12.34 | 26 | 40865 | 3451 | 50560782 |
SJS-TEN overlap | 34.51 | 12.34 | 11 | 40880 | 210 | 50564023 |
Sinusitis | 34.26 | 12.34 | 53 | 40838 | 170505 | 50393728 |
Haemodynamic instability | 33.94 | 12.34 | 37 | 40854 | 7987 | 50556246 |
Hepatic cytolysis | 33.64 | 12.34 | 37 | 40854 | 8066 | 50556167 |
Lower respiratory tract infection | 32.82 | 12.34 | 18 | 40873 | 95183 | 50469050 |
Product use issue | 32.42 | 12.34 | 44 | 40847 | 149431 | 50414802 |
Leukaemoid reaction | 32.29 | 12.34 | 10 | 40881 | 173 | 50564060 |
CSF measles antibody positive | 32.26 | 12.34 | 8 | 40883 | 57 | 50564176 |
Respiratory distress | 32.05 | 12.34 | 74 | 40817 | 30415 | 50533818 |
Blood creatinine increased | 31.88 | 12.34 | 134 | 40757 | 76026 | 50488207 |
Oliguria | 31.51 | 12.34 | 36 | 40855 | 8180 | 50556053 |
Rubella antibody positive | 31.45 | 12.34 | 8 | 40883 | 64 | 50564169 |
Migraine | 31.05 | 12.34 | 11 | 40880 | 75269 | 50488964 |
Leukopenia | 30.79 | 12.34 | 122 | 40769 | 67406 | 50496827 |
International normalised ratio increased | 30.25 | 12.34 | 90 | 40801 | 43062 | 50521171 |
Product use in unapproved indication | 30.11 | 12.34 | 178 | 40713 | 115641 | 50448592 |
Osteoarthritis | 30.10 | 12.34 | 9 | 40882 | 68597 | 50495636 |
Alanine aminotransferase increased | 29.91 | 12.34 | 146 | 40745 | 88213 | 50476020 |
Lip oedema | 29.90 | 12.34 | 23 | 40868 | 3170 | 50561063 |
Laryngeal stenosis | 29.75 | 12.34 | 14 | 40877 | 783 | 50563450 |
Shock | 29.73 | 12.34 | 57 | 40834 | 20593 | 50543640 |
Angioedema | 29.73 | 12.34 | 82 | 40809 | 37594 | 50526639 |
Rash erythematous | 29.65 | 12.34 | 78 | 40813 | 34774 | 50529459 |
Gastrointestinal disorder | 29.58 | 12.34 | 20 | 40871 | 94436 | 50469797 |
Blood brain barrier defect | 29.42 | 12.34 | 8 | 40883 | 85 | 50564148 |
Helicobacter infection | 29.40 | 12.34 | 3 | 40888 | 49699 | 50514534 |
Infusion related reaction | 29.23 | 12.34 | 58 | 40833 | 169499 | 50394734 |
Mobility decreased | 29.22 | 12.34 | 14 | 40877 | 79934 | 50484299 |
Clostridium test positive | 28.83 | 12.34 | 19 | 40872 | 2053 | 50562180 |
Hypokalaemia | 28.09 | 12.34 | 143 | 40748 | 87849 | 50476384 |
Enterobacter infection | 27.95 | 12.34 | 18 | 40873 | 1870 | 50562363 |
Immune reconstitution inflammatory syndrome | 27.92 | 12.34 | 28 | 40863 | 5488 | 50558745 |
Abdominal pain upper | 27.89 | 12.34 | 54 | 40837 | 159255 | 50404978 |
Intentional overdose | 27.79 | 12.34 | 8 | 40883 | 62496 | 50501737 |
Gastroenteritis clostridial | 27.75 | 12.34 | 12 | 40879 | 550 | 50563683 |
Treatment failure | 27.41 | 12.34 | 43 | 40848 | 137594 | 50426639 |
Autoimmune haemolytic anaemia | 27.36 | 12.34 | 24 | 40867 | 3975 | 50560258 |
Aspartate aminotransferase increased | 27.20 | 12.34 | 130 | 40761 | 77868 | 50486365 |
Bile duct stone | 27.06 | 12.34 | 22 | 40869 | 3285 | 50560948 |
Hepatic function abnormal | 26.65 | 12.34 | 72 | 40819 | 32609 | 50531624 |
Pelvic inflammatory disease | 26.28 | 12.34 | 16 | 40875 | 1506 | 50562727 |
CSF protein increased | 26.21 | 12.34 | 11 | 40880 | 468 | 50563765 |
Ill-defined disorder | 26.20 | 12.34 | 6 | 40885 | 54648 | 50509585 |
Cyanosis | 25.76 | 12.34 | 45 | 40846 | 15139 | 50549094 |
Factor V deficiency | 25.69 | 12.34 | 7 | 40884 | 75 | 50564158 |
Eosinophilic pneumonia | 25.38 | 12.34 | 17 | 40874 | 1887 | 50562346 |
Haemoperitoneum | 25.24 | 12.34 | 19 | 40872 | 2536 | 50561697 |
Bacteriuria | 25.21 | 12.34 | 12 | 40879 | 689 | 50563544 |
Blood pressure increased | 25.20 | 12.34 | 43 | 40848 | 133089 | 50431144 |
Klebsiella infection | 25.05 | 12.34 | 30 | 40861 | 7164 | 50557069 |
Stomatitis | 24.97 | 12.34 | 27 | 40864 | 101317 | 50462916 |
Weber tuning fork test abnormal | 24.97 | 12.34 | 7 | 40884 | 84 | 50564149 |
Thunderclap headache | 24.94 | 12.34 | 8 | 40883 | 156 | 50564077 |
Hepatitis infectious mononucleosis | 24.89 | 12.34 | 7 | 40884 | 85 | 50564148 |
Back pain | 24.62 | 12.34 | 93 | 40798 | 219937 | 50344296 |
Intervertebral discitis | 24.58 | 12.34 | 19 | 40872 | 2637 | 50561596 |
Hyporesponsive to stimuli | 24.53 | 12.34 | 13 | 40878 | 939 | 50563294 |
Myopathy toxic | 24.43 | 12.34 | 10 | 40881 | 399 | 50563834 |
Systemic inflammatory response syndrome | 24.41 | 12.34 | 25 | 40866 | 5024 | 50559209 |
Hypotension | 24.33 | 12.34 | 294 | 40597 | 235175 | 50329058 |
Clostridium colitis | 24.22 | 12.34 | 16 | 40875 | 1736 | 50562497 |
Face oedema | 24.17 | 12.34 | 48 | 40843 | 17791 | 50546442 |
Neurotoxicity | 24.13 | 12.34 | 43 | 40848 | 14697 | 50549536 |
Fibrin D dimer increased | 24.08 | 12.34 | 23 | 40868 | 4249 | 50559984 |
Erythema multiforme | 24.05 | 12.34 | 33 | 40858 | 9017 | 50555216 |
Renal tubular necrosis | 23.95 | 12.34 | 35 | 40856 | 10133 | 50554100 |
Myocardial infarction | 23.90 | 12.34 | 22 | 40869 | 89005 | 50475228 |
Organic brain syndrome | 23.66 | 12.34 | 8 | 40883 | 185 | 50564048 |
Pyelonephritis | 23.61 | 12.34 | 43 | 40848 | 14946 | 50549287 |
Neutrophilia | 23.55 | 12.34 | 21 | 40870 | 3554 | 50560679 |
Bronchial obstruction | 23.41 | 12.34 | 14 | 40877 | 1276 | 50562957 |
Pyelonephritis acute | 23.05 | 12.34 | 22 | 40869 | 4061 | 50560172 |
Electrolyte imbalance | 23.03 | 12.34 | 46 | 40845 | 17123 | 50547110 |
Maternal exposure during pregnancy | 22.83 | 12.34 | 213 | 40678 | 159565 | 50404668 |
Toxic skin eruption | 22.64 | 12.34 | 36 | 40855 | 11215 | 50553018 |
Otitis media acute | 22.57 | 12.34 | 12 | 40879 | 872 | 50563361 |
Unresponsive to stimuli | 22.56 | 12.34 | 65 | 40826 | 30544 | 50533689 |
Feeling abnormal | 22.43 | 12.34 | 42 | 40849 | 125450 | 50438783 |
Cardiogenic shock | 22.38 | 12.34 | 43 | 40848 | 15556 | 50548677 |
Renal papillary necrosis | 22.25 | 12.34 | 8 | 40883 | 223 | 50564010 |
Cholestatic liver injury | 22.15 | 12.34 | 16 | 40875 | 2005 | 50562228 |
Abdominal wall haematoma | 22.12 | 12.34 | 18 | 40873 | 2690 | 50561543 |
Meningism | 22.11 | 12.34 | 9 | 40882 | 354 | 50563879 |
Type I hypersensitivity | 21.94 | 12.34 | 17 | 40874 | 2368 | 50561865 |
Hospitalisation | 21.79 | 12.34 | 14 | 40877 | 67923 | 50496310 |
Toxicity to various agents | 21.76 | 12.34 | 93 | 40798 | 212406 | 50351827 |
Haemostasis | 21.73 | 12.34 | 8 | 40883 | 239 | 50563994 |
Folliculitis | 21.63 | 12.34 | 3 | 40888 | 39222 | 50525011 |
Haemodialysis | 21.48 | 12.34 | 30 | 40861 | 8332 | 50555901 |
Aspergillus infection | 21.42 | 12.34 | 27 | 40864 | 6794 | 50557439 |
Suicidal ideation | 21.33 | 12.34 | 9 | 40882 | 55376 | 50508857 |
Stress cardiomyopathy | 21.32 | 12.34 | 29 | 40862 | 7858 | 50556375 |
Anuria | 21.30 | 12.34 | 35 | 40856 | 11209 | 50553024 |
Hypertension | 21.28 | 12.34 | 93 | 40798 | 211110 | 50353123 |
Drug abuse | 21.09 | 12.34 | 11 | 40880 | 59835 | 50504398 |
Morganella infection | 20.99 | 12.34 | 10 | 40881 | 575 | 50563658 |
Nephropathy toxic | 20.92 | 12.34 | 29 | 40862 | 8000 | 50556233 |
Disseminated intravascular coagulation | 20.73 | 12.34 | 44 | 40847 | 17091 | 50547142 |
Balance disorder | 20.72 | 12.34 | 16 | 40875 | 70574 | 50493659 |
Intravascular haemolysis | 20.67 | 12.34 | 8 | 40883 | 275 | 50563958 |
Cholangitis acute | 20.62 | 12.34 | 9 | 40882 | 422 | 50563811 |
Iris transillumination defect | 20.62 | 12.34 | 6 | 40885 | 83 | 50564150 |
Hyperthyroidism | 20.55 | 12.34 | 36 | 40855 | 12139 | 50552094 |
Veillonella infection | 20.50 | 12.34 | 5 | 40886 | 33 | 50564200 |
Meningitis | 20.46 | 12.34 | 25 | 40866 | 6096 | 50558137 |
Inflammatory marker increased | 20.45 | 12.34 | 24 | 40867 | 5610 | 50558623 |
Coagulation factor deficiency | 20.45 | 12.34 | 4 | 40887 | 7 | 50564226 |
Jaundice | 20.33 | 12.34 | 57 | 40834 | 26372 | 50537861 |
Dry mouth | 20.28 | 12.34 | 10 | 40881 | 56168 | 50508065 |
Impaired healing | 20.26 | 12.34 | 16 | 40875 | 69770 | 50494463 |
Normal newborn | 20.24 | 12.34 | 26 | 40865 | 6665 | 50557568 |
Laryngeal mass | 20.24 | 12.34 | 5 | 40886 | 35 | 50564198 |
Hepatosplenomegaly | 20.23 | 12.34 | 16 | 40875 | 2296 | 50561937 |
Nasal congestion | 20.19 | 12.34 | 8 | 40883 | 51112 | 50513121 |
Erythema nodosum | 20.10 | 12.34 | 20 | 40871 | 3883 | 50560350 |
Multiple sclerosis relapse | 20.04 | 12.34 | 5 | 40886 | 42959 | 50521274 |
Eosinophilic pneumonia acute | 19.96 | 12.34 | 8 | 40883 | 302 | 50563931 |
COVID-19 pneumonia | 19.92 | 12.34 | 29 | 40862 | 8366 | 50555867 |
Septic pulmonary embolism | 19.66 | 12.34 | 5 | 40886 | 40 | 50564193 |
Acquired haemophilia | 19.58 | 12.34 | 11 | 40880 | 892 | 50563341 |
Cataract | 19.35 | 12.34 | 7 | 40884 | 47293 | 50516940 |
Palpitations | 19.31 | 12.34 | 29 | 40862 | 94477 | 50469756 |
Anxiety | 19.26 | 12.34 | 76 | 40815 | 177530 | 50386703 |
Drug eruption | 19.24 | 12.34 | 52 | 40839 | 23554 | 50540679 |
Coagulation factor decreased | 19.23 | 12.34 | 5 | 40886 | 44 | 50564189 |
Postpartum sepsis | 19.21 | 12.34 | 4 | 40887 | 11 | 50564222 |
Blood pressure fluctuation | 19.15 | 12.34 | 3 | 40888 | 35820 | 50528413 |
Respiratory acidosis | 19.15 | 12.34 | 24 | 40867 | 6004 | 50558229 |
Hypoaesthesia | 19.07 | 12.34 | 47 | 40844 | 127210 | 50437023 |
Endocarditis | 18.95 | 12.34 | 22 | 40869 | 5085 | 50559148 |
Transverse sinus thrombosis | 18.93 | 12.34 | 9 | 40882 | 515 | 50563718 |
Bronchopleural fistula | 18.86 | 12.34 | 7 | 40884 | 214 | 50564019 |
Encephalitis brain stem | 18.70 | 12.34 | 6 | 40885 | 117 | 50564116 |
Agitation | 18.62 | 12.34 | 89 | 40802 | 53295 | 50510938 |
Memory impairment | 18.61 | 12.34 | 22 | 40869 | 79338 | 50484895 |
Liver injury | 18.59 | 12.34 | 53 | 40838 | 24753 | 50539480 |
Pneumonia necrotising | 18.39 | 12.34 | 8 | 40883 | 372 | 50563861 |
Hypercreatininaemia | 18.37 | 12.34 | 8 | 40883 | 373 | 50563860 |
Red blood cell agglutination | 18.37 | 12.34 | 3 | 40888 | 0 | 50564233 |
Anti factor V antibody | 18.37 | 12.34 | 3 | 40888 | 0 | 50564233 |
Unmasking of previously unidentified disease | 18.30 | 12.34 | 10 | 40881 | 768 | 50563465 |
Influenza like illness | 18.21 | 12.34 | 12 | 40879 | 57447 | 50506786 |
Hepatic enzyme increased | 18.14 | 12.34 | 54 | 40837 | 137326 | 50426907 |
Gastrooesophageal reflux disease | 18.13 | 12.34 | 21 | 40870 | 76407 | 50487826 |
Partial seizures | 18.12 | 12.34 | 21 | 40870 | 4844 | 50559389 |
Dyspepsia | 17.96 | 12.34 | 20 | 40871 | 74077 | 50490156 |
Dermatitis exfoliative generalised | 17.94 | 12.34 | 17 | 40874 | 3109 | 50561124 |
Cerebral artery stenosis | 17.92 | 12.34 | 8 | 40883 | 396 | 50563837 |
Condition aggravated | 17.84 | 12.34 | 338 | 40553 | 296720 | 50267513 |
Drug hypersensitivity | 17.70 | 12.34 | 293 | 40598 | 250717 | 50313516 |
Asymptomatic bacteriuria | 17.62 | 12.34 | 7 | 40884 | 258 | 50563975 |
Nocardiosis | 17.61 | 12.34 | 13 | 40878 | 1685 | 50562548 |
Hyperglycaemia | 17.58 | 12.34 | 67 | 40824 | 36338 | 50527895 |
Hypofibrinogenaemia | 17.45 | 12.34 | 11 | 40880 | 1101 | 50563132 |
Hyperlactacidaemia | 17.45 | 12.34 | 15 | 40876 | 2418 | 50561815 |
Conjunctival hyperaemia | 17.35 | 12.34 | 14 | 40877 | 2068 | 50562165 |
Wound haemorrhage | 17.30 | 12.34 | 14 | 40877 | 2076 | 50562157 |
Rash | 17.26 | 12.34 | 469 | 40422 | 437002 | 50127231 |
Infantile apnoea | 17.22 | 12.34 | 10 | 40881 | 863 | 50563370 |
Hyperbilirubinaemia | 17.07 | 12.34 | 29 | 40862 | 9541 | 50554692 |
Normochromic anaemia | 17.04 | 12.34 | 7 | 40884 | 282 | 50563951 |
Adverse event | 17.03 | 12.34 | 7 | 40884 | 43756 | 50520477 |
Skin test positive | 17.03 | 12.34 | 9 | 40882 | 646 | 50563587 |
Relapsing fever | 16.97 | 12.34 | 6 | 40885 | 159 | 50564074 |
Confabulation | 16.88 | 12.34 | 7 | 40884 | 289 | 50563944 |
Sleep disorder | 16.79 | 12.34 | 13 | 40878 | 57270 | 50506963 |
Hepatitis acute | 16.75 | 12.34 | 26 | 40865 | 7935 | 50556298 |
Pseudophaeochromocytoma | 16.69 | 12.34 | 5 | 40886 | 77 | 50564156 |
Injection site pruritus | 16.50 | 12.34 | 6 | 40885 | 40405 | 50523828 |
Hypoalbuminaemia | 16.44 | 12.34 | 29 | 40862 | 9831 | 50554402 |
Purpura | 16.33 | 12.34 | 29 | 40862 | 9882 | 50554351 |
Antibiotic associated colitis | 16.29 | 12.34 | 3 | 40888 | 3 | 50564230 |
Fibromyalgia | 16.25 | 12.34 | 8 | 40883 | 44970 | 50519263 |
Encephalitis autoimmune | 16.21 | 12.34 | 11 | 40880 | 1247 | 50562986 |
Clostridial infection | 16.18 | 12.34 | 18 | 40873 | 3972 | 50560261 |
Stomatococcal infection | 16.17 | 12.34 | 5 | 40886 | 86 | 50564147 |
Hyperthermia malignant | 16.01 | 12.34 | 9 | 40882 | 730 | 50563503 |
Eyelid oedema | 15.99 | 12.34 | 28 | 40863 | 9438 | 50554795 |
Musculoskeletal pain | 15.89 | 12.34 | 21 | 40870 | 72156 | 50492077 |
Normocytic anaemia | 15.68 | 12.34 | 11 | 40880 | 1316 | 50562917 |
Gamma-glutamyltransferase increased | 15.55 | 12.34 | 56 | 40835 | 29567 | 50534666 |
Escherichia infection | 15.50 | 12.34 | 30 | 40861 | 10911 | 50553322 |
Haematoma | 15.44 | 12.34 | 57 | 40834 | 30453 | 50533780 |
Cerebral aspergillosis | 15.43 | 12.34 | 7 | 40884 | 360 | 50563873 |
Myocarditis | 15.41 | 12.34 | 25 | 40866 | 7922 | 50556311 |
Nephritis | 15.38 | 12.34 | 13 | 40878 | 2049 | 50562184 |
Vision blurred | 15.24 | 12.34 | 25 | 40866 | 78622 | 50485611 |
Type IV hypersensitivity reaction | 15.21 | 12.34 | 14 | 40877 | 2468 | 50561765 |
Herpes zoster | 15.17 | 12.34 | 21 | 40870 | 70765 | 50493468 |
Dry skin | 15.13 | 12.34 | 8 | 40883 | 43183 | 50521050 |
Post treatment Lyme disease syndrome | 15.07 | 12.34 | 3 | 40888 | 6 | 50564227 |
Anaemia | 15.06 | 12.34 | 287 | 40604 | 252169 | 50312064 |
Neisseria infection | 15.02 | 12.34 | 4 | 40887 | 39 | 50564194 |
Anoxia | 14.96 | 12.34 | 6 | 40885 | 227 | 50564006 |
Foetal death | 14.87 | 12.34 | 25 | 40866 | 8155 | 50556078 |
Pneumonia mycoplasmal | 14.85 | 12.34 | 9 | 40882 | 840 | 50563393 |
Mixed liver injury | 14.74 | 12.34 | 16 | 40875 | 3435 | 50560798 |
Candida test positive | 14.71 | 12.34 | 9 | 40882 | 855 | 50563378 |
Orthostatic hypotension | 14.61 | 12.34 | 3 | 40888 | 29478 | 50534755 |
CSF oligoclonal band present | 14.57 | 12.34 | 5 | 40886 | 121 | 50564112 |
Ventricular dysfunction | 14.56 | 12.34 | 14 | 40877 | 2607 | 50561626 |
Hemianopia | 14.54 | 12.34 | 9 | 40882 | 873 | 50563360 |
Vitamin K deficiency | 14.48 | 12.34 | 7 | 40884 | 416 | 50563817 |
Overlap syndrome | 14.41 | 12.34 | 8 | 40883 | 634 | 50563599 |
Brain herniation | 14.39 | 12.34 | 15 | 40876 | 3077 | 50561156 |
Meningitis bacterial | 14.35 | 12.34 | 10 | 40881 | 1184 | 50563049 |
Anti-platelet antibody positive | 14.34 | 12.34 | 4 | 40887 | 47 | 50564186 |
Hypertensive heart disease | 14.29 | 12.34 | 13 | 40878 | 2257 | 50561976 |
Chemotherapeutic drug level increased | 14.02 | 12.34 | 5 | 40886 | 136 | 50564097 |
Visual impairment | 13.90 | 12.34 | 21 | 40870 | 68254 | 50495979 |
Systemic candida | 13.82 | 12.34 | 14 | 40877 | 2776 | 50561457 |
Ventricular fibrillation | 13.81 | 12.34 | 28 | 40863 | 10531 | 50553702 |
Ear pain | 13.77 | 12.34 | 3 | 40888 | 28280 | 50535953 |
Superior sagittal sinus thrombosis | 13.69 | 12.34 | 8 | 40883 | 699 | 50563534 |
Cardiac tamponade | 13.68 | 12.34 | 17 | 40874 | 4215 | 50560018 |
Stress | 13.62 | 12.34 | 14 | 40877 | 53779 | 50510454 |
Thrombosis | 13.61 | 12.34 | 15 | 40876 | 55818 | 50508415 |
Therapeutic product effect incomplete | 13.55 | 12.34 | 34 | 40857 | 91481 | 50472752 |
Bronchospasm | 13.41 | 12.34 | 34 | 40857 | 14820 | 50549413 |
Hypoxic-ischaemic encephalopathy | 13.34 | 12.34 | 16 | 40875 | 3826 | 50560407 |
Hyperthermia | 13.31 | 12.34 | 23 | 40868 | 7673 | 50556560 |
Cholecystitis acute | 13.30 | 12.34 | 22 | 40869 | 7084 | 50557149 |
Microangiopathic haemolytic anaemia | 13.29 | 12.34 | 7 | 40884 | 499 | 50563734 |
Ureterolithiasis | 13.29 | 12.34 | 11 | 40880 | 1684 | 50562549 |
Acute hepatic failure | 13.24 | 12.34 | 35 | 40856 | 15642 | 50548591 |
Alpha 1 microglobulin increased | 13.21 | 12.34 | 4 | 40887 | 64 | 50564169 |
Leukoencephalopathy | 13.21 | 12.34 | 16 | 40875 | 3867 | 50560366 |
Pallor | 13.16 | 12.34 | 45 | 40846 | 23154 | 50541079 |
Tracheobronchitis | 13.15 | 12.34 | 9 | 40882 | 1035 | 50563198 |
Muscle haemorrhage | 13.14 | 12.34 | 14 | 40877 | 2944 | 50561289 |
Fluid retention | 13.03 | 12.34 | 13 | 40878 | 50636 | 50513597 |
Bacteraemia | 12.99 | 12.34 | 33 | 40858 | 14400 | 50549833 |
Neuroglycopenia | 12.87 | 12.34 | 4 | 40887 | 70 | 50564163 |
Inappropriate schedule of product administration | 12.86 | 12.34 | 24 | 40867 | 71807 | 50492426 |
Kidney enlargement | 12.82 | 12.34 | 7 | 40884 | 537 | 50563696 |
Neuropathy peripheral | 12.79 | 12.34 | 38 | 40853 | 96719 | 50467514 |
Brain abscess | 12.76 | 12.34 | 11 | 40880 | 1780 | 50562453 |
Septic embolus | 12.64 | 12.34 | 8 | 40883 | 807 | 50563426 |
Hyperkalaemia | 12.54 | 12.34 | 74 | 40817 | 48015 | 50516218 |
Infection | 12.53 | 12.34 | 85 | 40806 | 172869 | 50391364 |
Central nervous system vasculitis | 12.52 | 12.34 | 8 | 40883 | 820 | 50563413 |
Base excess | 12.47 | 12.34 | 4 | 40887 | 78 | 50564155 |
Coombs negative haemolytic anaemia | 12.45 | 12.34 | 5 | 40886 | 190 | 50564043 |
Respiratory disorder | 12.37 | 12.34 | 54 | 40837 | 31133 | 50533100 |
Stridor | 12.35 | 12.34 | 14 | 40877 | 3155 | 50561078 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Off label use | 427.43 | 12.21 | 1203 | 43566 | 299597 | 29230161 |
Drug reaction with eosinophilia and systemic symptoms | 346.11 | 12.21 | 308 | 44461 | 27684 | 29502074 |
Postrenal failure | 292.14 | 12.21 | 77 | 44692 | 348 | 29529410 |
Jarisch-Herxheimer reaction | 260.51 | 12.21 | 69 | 44700 | 319 | 29529439 |
Pseudocholelithiasis | 214.31 | 12.21 | 39 | 44730 | 0 | 29529758 |
Rash maculo-papular | 177.50 | 12.21 | 201 | 44568 | 24088 | 29505670 |
Acute kidney injury | 156.87 | 12.21 | 803 | 43966 | 264464 | 29265294 |
Acute generalised exanthematous pustulosis | 150.70 | 12.21 | 98 | 44671 | 5485 | 29524273 |
Cholestasis | 146.26 | 12.21 | 179 | 44590 | 23283 | 29506475 |
Cholelithiasis | 145.83 | 12.21 | 160 | 44609 | 18512 | 29511246 |
Appendicolith | 142.96 | 12.21 | 80 | 44689 | 3400 | 29526358 |
Fatigue | 140.73 | 12.21 | 164 | 44605 | 316657 | 29213101 |
Death | 136.54 | 12.21 | 192 | 44577 | 341892 | 29187866 |
Toxic epidermal necrolysis | 133.93 | 12.21 | 151 | 44618 | 18002 | 29511756 |
Eosinophilia | 133.19 | 12.21 | 166 | 44603 | 21995 | 29507763 |
Hepatocellular injury | 132.29 | 12.21 | 162 | 44607 | 21081 | 29508677 |
Hypertransaminasaemia | 121.82 | 12.21 | 73 | 44696 | 3533 | 29526225 |
Multiple organ dysfunction syndrome | 110.57 | 12.21 | 274 | 44495 | 62842 | 29466916 |
Anaphylactic shock | 107.12 | 12.21 | 116 | 44653 | 13220 | 29516538 |
Pyrexia | 106.25 | 12.21 | 771 | 43998 | 286851 | 29242907 |
Agranulocytosis | 104.47 | 12.21 | 141 | 44628 | 20199 | 29509559 |
Toxic encephalopathy | 100.71 | 12.21 | 71 | 44698 | 4541 | 29525217 |
Hepatitis | 100.60 | 12.21 | 140 | 44629 | 20643 | 29509115 |
Product dose omission issue | 96.97 | 12.21 | 15 | 44754 | 96368 | 29433390 |
Anaphylactic reaction | 95.55 | 12.21 | 159 | 44610 | 27414 | 29502344 |
Appendicitis | 95.51 | 12.21 | 90 | 44679 | 8689 | 29521069 |
Cardiogenic shock | 95.48 | 12.21 | 131 | 44638 | 19059 | 29510699 |
Ureterolithiasis | 94.31 | 12.21 | 49 | 44720 | 1791 | 29527967 |
Pathogen resistance | 93.70 | 12.21 | 86 | 44683 | 8030 | 29521728 |
Drug abuse | 91.34 | 12.21 | 8 | 44761 | 79875 | 29449883 |
Haemolytic anaemia | 88.31 | 12.21 | 89 | 44680 | 9330 | 29520428 |
Long QT syndrome | 87.59 | 12.21 | 50 | 44719 | 2208 | 29527550 |
Drug-induced liver injury | 86.16 | 12.21 | 133 | 44636 | 21522 | 29508236 |
Recalled product administered | 84.11 | 12.21 | 30 | 44739 | 422 | 29529336 |
Dizziness | 79.95 | 12.21 | 102 | 44667 | 189582 | 29340176 |
Depression | 79.65 | 12.21 | 16 | 44753 | 85131 | 29444627 |
Myocardial infarction | 75.92 | 12.21 | 36 | 44733 | 110260 | 29419498 |
Fall | 74.95 | 12.21 | 95 | 44674 | 177083 | 29352675 |
Clostridium difficile colitis | 74.65 | 12.21 | 96 | 44673 | 13116 | 29516642 |
Bronchopulmonary aspergillosis | 71.81 | 12.21 | 91 | 44678 | 12253 | 29517505 |
Immune reconstitution inflammatory syndrome | 70.00 | 12.21 | 72 | 44697 | 7730 | 29522028 |
Haemolysis | 69.41 | 12.21 | 68 | 44701 | 6888 | 29522870 |
Alanine aminotransferase increased | 68.86 | 12.21 | 250 | 44519 | 70694 | 29459064 |
Septic shock | 67.23 | 12.21 | 228 | 44541 | 62332 | 29467426 |
Factor V inhibition | 66.98 | 12.21 | 20 | 44749 | 153 | 29529605 |
Weight increased | 66.51 | 12.21 | 17 | 44752 | 76650 | 29453108 |
Hydronephrosis | 63.32 | 12.21 | 72 | 44697 | 8658 | 29521100 |
Tubulointerstitial nephritis | 58.79 | 12.21 | 100 | 44669 | 17543 | 29512215 |
Electrocardiogram QT prolonged | 58.15 | 12.21 | 152 | 44617 | 35985 | 29493773 |
Respiratory failure | 54.92 | 12.21 | 291 | 44478 | 96840 | 29432918 |
Transaminases increased | 50.22 | 12.21 | 108 | 44661 | 22554 | 29507204 |
Anuria | 48.76 | 12.21 | 66 | 44703 | 9475 | 29520283 |
Pain | 48.74 | 12.21 | 118 | 44651 | 171314 | 29358444 |
Stevens-Johnson syndrome | 47.86 | 12.21 | 88 | 44681 | 16409 | 29513349 |
Insomnia | 47.22 | 12.21 | 39 | 44730 | 88722 | 29441036 |
Cerebrovascular accident | 47.20 | 12.21 | 29 | 44740 | 76882 | 29452876 |
Nocardiosis | 46.57 | 12.21 | 39 | 44730 | 3221 | 29526537 |
Liver injury | 46.40 | 12.21 | 75 | 44694 | 12615 | 29517143 |
Acute respiratory distress syndrome | 45.98 | 12.21 | 105 | 44664 | 22830 | 29506928 |
Brain abscess | 44.78 | 12.21 | 35 | 44734 | 2620 | 29527138 |
Inflammatory marker increased | 44.56 | 12.21 | 40 | 44729 | 3627 | 29526131 |
Thrombocytopenia | 44.20 | 12.21 | 352 | 44417 | 134471 | 29395287 |
Blood glucose increased | 44.15 | 12.21 | 17 | 44752 | 58967 | 29470791 |
Disseminated intravascular coagulation | 44.02 | 12.21 | 95 | 44674 | 19885 | 29509873 |
Pruritus | 43.88 | 12.21 | 315 | 44454 | 116534 | 29413224 |
Cross sensitivity reaction | 43.80 | 12.21 | 26 | 44743 | 1236 | 29528522 |
Hospitalisation | 42.24 | 12.21 | 9 | 44760 | 45979 | 29483779 |
Ureteral disorder | 41.42 | 12.21 | 14 | 44755 | 166 | 29529592 |
Joint swelling | 41.16 | 12.21 | 12 | 44757 | 49618 | 29480140 |
Product use in unapproved indication | 39.72 | 12.21 | 246 | 44523 | 86629 | 29443129 |
Klebsiella infection | 39.33 | 12.21 | 52 | 44717 | 7297 | 29522461 |
Toxicity to various agents | 38.77 | 12.21 | 134 | 44635 | 173527 | 29356231 |
Anxiety | 37.90 | 12.21 | 44 | 44725 | 85321 | 29444437 |
Disseminated cryptococcosis | 37.60 | 12.21 | 23 | 44746 | 1155 | 29528603 |
Cryptococcal meningoencephalitis | 37.53 | 12.21 | 12 | 44757 | 118 | 29529640 |
Abdominal discomfort | 37.21 | 12.21 | 13 | 44756 | 47890 | 29481868 |
COVID-19 pneumonia | 37.19 | 12.21 | 58 | 44711 | 9464 | 29520294 |
Ascites | 37.16 | 12.21 | 131 | 44638 | 36488 | 29493270 |
Portal fibrosis | 36.94 | 12.21 | 15 | 44754 | 306 | 29529452 |
Liver function test increased | 36.51 | 12.21 | 65 | 44704 | 11820 | 29517938 |
Hepatitis toxic | 36.14 | 12.21 | 27 | 44742 | 1889 | 29527869 |
Arthralgia | 35.91 | 12.21 | 101 | 44668 | 139516 | 29390242 |
Ventricular fibrillation | 35.70 | 12.21 | 76 | 44693 | 15757 | 29514001 |
Cardiac failure congestive | 35.61 | 12.21 | 38 | 44731 | 76543 | 29453215 |
Condition aggravated | 35.13 | 12.21 | 357 | 44412 | 145938 | 29383820 |
Drug resistance | 35.04 | 12.21 | 91 | 44678 | 21449 | 29508309 |
Kounis syndrome | 35.01 | 12.21 | 26 | 44743 | 1803 | 29527955 |
Fixed eruption | 34.66 | 12.21 | 22 | 44747 | 1180 | 29528578 |
Pain in extremity | 34.62 | 12.21 | 72 | 44697 | 110361 | 29419397 |
Drug ineffective for unapproved indication | 34.12 | 12.21 | 70 | 44699 | 14144 | 29515614 |
Torsade de pointes | 33.92 | 12.21 | 46 | 44723 | 6615 | 29523143 |
Flank pain | 33.57 | 12.21 | 43 | 44726 | 5850 | 29523908 |
Hyperferritinaemia | 32.84 | 12.21 | 14 | 44755 | 324 | 29529434 |
Hepatitis cholestatic | 32.69 | 12.21 | 46 | 44723 | 6847 | 29522911 |
Trichosporon infection | 32.68 | 12.21 | 17 | 44752 | 623 | 29529135 |
Asthenia | 32.49 | 12.21 | 192 | 44577 | 215058 | 29314700 |
Toxic skin eruption | 32.10 | 12.21 | 55 | 44714 | 9702 | 29520056 |
Crying | 31.99 | 12.21 | 40 | 44729 | 5311 | 29524447 |
Rash morbilliform | 31.90 | 12.21 | 28 | 44741 | 2465 | 29527293 |
Hepatic enzyme increased | 31.82 | 12.21 | 118 | 44651 | 33681 | 29496077 |
Muscle spasms | 31.73 | 12.21 | 31 | 44738 | 65051 | 29464707 |
Feeling abnormal | 31.40 | 12.21 | 22 | 44747 | 54423 | 29475335 |
Clostridium difficile infection | 31.36 | 12.21 | 73 | 44696 | 16068 | 29513690 |
Hyponatraemia | 31.20 | 12.21 | 192 | 44577 | 67441 | 29462317 |
Stress | 31.15 | 12.21 | 87 | 44682 | 21403 | 29508355 |
Urticaria | 31.01 | 12.21 | 164 | 44605 | 54496 | 29475262 |
Pseudomembranous colitis | 30.91 | 12.21 | 28 | 44741 | 2569 | 29527189 |
Nasopharyngitis | 30.76 | 12.21 | 27 | 44742 | 59638 | 29470120 |
Alcohol intolerance | 30.75 | 12.21 | 14 | 44755 | 381 | 29529377 |
Choreoathetosis | 30.24 | 12.21 | 19 | 44750 | 1001 | 29528757 |
Hepatomegaly | 29.97 | 12.21 | 52 | 44717 | 9265 | 29520493 |
Inappropriate schedule of product administration | 29.83 | 12.21 | 15 | 44754 | 44457 | 29485301 |
Coronary artery disease | 29.50 | 12.21 | 15 | 44754 | 44175 | 29485583 |
Drug interaction | 29.31 | 12.21 | 440 | 44329 | 196945 | 29332813 |
Encephalitis | 29.15 | 12.21 | 42 | 44727 | 6388 | 29523370 |
Cardiac disorder | 29.13 | 12.21 | 10 | 44759 | 37253 | 29492505 |
Aspartate aminotransferase increased | 29.11 | 12.21 | 172 | 44597 | 59553 | 29470205 |
Malignant mesenteric neoplasm | 29.05 | 12.21 | 8 | 44761 | 44 | 29529714 |
Sphincter of Oddi dysfunction | 29.04 | 12.21 | 10 | 44759 | 126 | 29529632 |
Intentional overdose | 29.00 | 12.21 | 11 | 44758 | 38517 | 29491241 |
Hepatitis acute | 28.99 | 12.21 | 42 | 44727 | 6420 | 29523338 |
Hypoxia | 28.85 | 12.21 | 145 | 44624 | 47234 | 29482524 |
Acute hepatic failure | 28.85 | 12.21 | 59 | 44710 | 11893 | 29517865 |
Drug intolerance | 28.63 | 12.21 | 19 | 44750 | 48360 | 29481398 |
Procalcitonin increased | 28.46 | 12.21 | 22 | 44747 | 1620 | 29528138 |
Neutropenia | 28.14 | 12.21 | 314 | 44455 | 131397 | 29398361 |
Leukocytosis | 28.13 | 12.21 | 83 | 44686 | 21059 | 29508699 |
Diarrhoea | 28.02 | 12.21 | 346 | 44423 | 332352 | 29197406 |
Dry gangrene | 27.76 | 12.21 | 13 | 44756 | 378 | 29529380 |
No adverse event | 27.57 | 12.21 | 73 | 44696 | 17405 | 29512353 |
Hyper IgE syndrome | 27.53 | 12.21 | 8 | 44761 | 55 | 29529703 |
Hepatic function abnormal | 27.42 | 12.21 | 125 | 44644 | 39134 | 29490624 |
Tachypnoea | 26.82 | 12.21 | 66 | 44703 | 15049 | 29514709 |
Dehydration | 26.63 | 12.21 | 87 | 44682 | 114661 | 29415097 |
Therapeutic product effect decreased | 26.57 | 12.21 | 6 | 44763 | 29445 | 29500313 |
Corynebacterium infection | 26.52 | 12.21 | 13 | 44756 | 419 | 29529339 |
Cyanosis | 26.47 | 12.21 | 55 | 44714 | 11212 | 29518546 |
Device related sepsis | 26.03 | 12.21 | 25 | 44744 | 2470 | 29527288 |
Suicidal ideation | 25.98 | 12.21 | 10 | 44759 | 34706 | 29495052 |
Jejunal ulcer perforation | 25.85 | 12.21 | 8 | 44761 | 70 | 29529688 |
Jaundice | 25.69 | 12.21 | 100 | 44669 | 29196 | 29500562 |
Janeway lesion | 25.48 | 12.21 | 6 | 44763 | 15 | 29529743 |
Metastases to stomach | 25.26 | 12.21 | 8 | 44761 | 76 | 29529682 |
Pleocytosis | 25.20 | 12.21 | 13 | 44756 | 468 | 29529290 |
Neurotoxicity | 25.08 | 12.21 | 63 | 44706 | 14550 | 29515208 |
Bacterial pericarditis | 25.05 | 12.21 | 7 | 44762 | 41 | 29529717 |
Myasthenia gravis crisis | 24.95 | 12.21 | 13 | 44756 | 478 | 29529280 |
Contusion | 24.91 | 12.21 | 8 | 44761 | 31087 | 29498671 |
Headache | 24.78 | 12.21 | 158 | 44611 | 173849 | 29355909 |
Escherichia infection | 24.76 | 12.21 | 40 | 44729 | 6724 | 29523034 |
Gait disturbance | 24.55 | 12.21 | 46 | 44723 | 73303 | 29456455 |
Angina pectoris | 24.48 | 12.21 | 6 | 44763 | 27844 | 29501914 |
Candida infection | 24.43 | 12.21 | 64 | 44705 | 15161 | 29514597 |
Enterobacter infection | 24.35 | 12.21 | 22 | 44747 | 2012 | 29527746 |
Drug effective for unapproved indication | 24.15 | 12.21 | 19 | 44750 | 1436 | 29528322 |
Crystalluria | 24.03 | 12.21 | 12 | 44757 | 403 | 29529355 |
Erythema | 23.97 | 12.21 | 196 | 44573 | 75410 | 29454348 |
Chest pain | 23.89 | 12.21 | 88 | 44681 | 111885 | 29417873 |
Acute respiratory failure | 23.87 | 12.21 | 91 | 44678 | 26311 | 29503447 |
Wrong technique in product usage process | 23.61 | 12.21 | 9 | 44760 | 31419 | 29498339 |
Coagulopathy | 23.54 | 12.21 | 70 | 44699 | 17837 | 29511921 |
COVID-19 | 23.19 | 12.21 | 112 | 44657 | 35902 | 29493856 |
Sepsis | 23.10 | 12.21 | 323 | 44446 | 142359 | 29387399 |
Cerebral cyst | 22.89 | 12.21 | 10 | 44759 | 246 | 29529512 |
Blood alkaline phosphatase increased | 22.55 | 12.21 | 94 | 44675 | 28312 | 29501446 |
Malignant neoplasm progression | 22.43 | 12.21 | 49 | 44720 | 73810 | 29455948 |
Mucormycosis | 22.38 | 12.21 | 33 | 44736 | 5125 | 29524633 |
Muscle abscess | 22.38 | 12.21 | 12 | 44757 | 468 | 29529290 |
Omental necrosis | 22.26 | 12.21 | 6 | 44763 | 30 | 29529728 |
Respiratory distress | 22.25 | 12.21 | 102 | 44667 | 32004 | 29497754 |
Oliguria | 22.08 | 12.21 | 40 | 44729 | 7372 | 29522386 |
Infective chondritis | 22.00 | 12.21 | 5 | 44764 | 10 | 29529748 |
Antimicrobial susceptibility test resistant | 21.97 | 12.21 | 10 | 44759 | 272 | 29529486 |
Eastern Cooperative Oncology Group performance status | 21.79 | 12.21 | 6 | 44763 | 33 | 29529725 |
Tissue infiltration | 21.70 | 12.21 | 7 | 44762 | 71 | 29529687 |
Clostridium test positive | 21.69 | 12.21 | 21 | 44748 | 2096 | 29527662 |
Erythema nodosum | 21.65 | 12.21 | 15 | 44754 | 932 | 29528826 |
Splenomegaly | 21.49 | 12.21 | 56 | 44713 | 13223 | 29516535 |
Weight decreased | 21.49 | 12.21 | 137 | 44632 | 150768 | 29378990 |
Prostate cancer | 21.48 | 12.21 | 6 | 44763 | 25521 | 29504237 |
Coagulation factor decreased | 21.27 | 12.21 | 7 | 44762 | 76 | 29529682 |
Procalcitonin abnormal | 21.00 | 12.21 | 10 | 44759 | 302 | 29529456 |
Type IV hypersensitivity reaction | 20.94 | 12.21 | 16 | 44753 | 1158 | 29528600 |
Pulmonary physical examination abnormal | 20.82 | 12.21 | 5 | 44764 | 14 | 29529744 |
Rash | 20.81 | 12.21 | 403 | 44366 | 189416 | 29340342 |
Malaise | 20.68 | 12.21 | 149 | 44620 | 159453 | 29370305 |
Bile duct stone | 20.67 | 12.21 | 21 | 44748 | 2221 | 29527537 |
Dry mouth | 20.55 | 12.21 | 4 | 44765 | 21780 | 29507978 |
Balance disorder | 20.35 | 12.21 | 15 | 44754 | 36155 | 29493603 |
Red blood cell schistocytes present | 20.18 | 12.21 | 9 | 44760 | 233 | 29529525 |
Liver transplant failure | 20.06 | 12.21 | 7 | 44762 | 92 | 29529666 |
Mobility decreased | 20.01 | 12.21 | 7 | 44762 | 25773 | 29503985 |
Faeces pale | 19.95 | 12.21 | 16 | 44753 | 1243 | 29528515 |
Endocarditis | 19.83 | 12.21 | 33 | 44736 | 5683 | 29524075 |
Hypertension | 19.76 | 12.21 | 100 | 44669 | 116514 | 29413244 |
Vision blurred | 19.73 | 12.21 | 19 | 44750 | 40157 | 29489601 |
Serum sickness-like reaction | 19.72 | 12.21 | 7 | 44762 | 97 | 29529661 |
Drug dependence | 19.48 | 12.21 | 4 | 44765 | 20977 | 29508781 |
Antinuclear antibody negative | 19.46 | 12.21 | 5 | 44764 | 20 | 29529738 |
Incorrect dose administered | 19.45 | 12.21 | 13 | 44756 | 32971 | 29496787 |
Memory impairment | 19.41 | 12.21 | 16 | 44753 | 36454 | 29493304 |
Syncope | 19.35 | 12.21 | 61 | 44708 | 81310 | 29448448 |
Cataract | 19.32 | 12.21 | 5 | 44764 | 22373 | 29507385 |
Calculus urinary | 19.04 | 12.21 | 15 | 44754 | 1136 | 29528622 |
Overdose | 18.87 | 12.21 | 60 | 44709 | 79759 | 29449999 |
Infective spondylitis | 18.85 | 12.21 | 8 | 44761 | 183 | 29529575 |
Haemophagocytic lymphohistiocytosis | 18.78 | 12.21 | 46 | 44723 | 10458 | 29519300 |
Peripheral swelling | 18.77 | 12.21 | 43 | 44726 | 63696 | 29466062 |
Hyperamylasaemia | 18.64 | 12.21 | 11 | 44758 | 517 | 29529241 |
Interleukin-2 receptor increased | 18.63 | 12.21 | 7 | 44762 | 115 | 29529643 |
Transient ischaemic attack | 18.62 | 12.21 | 6 | 44763 | 23264 | 29506494 |
Dyspnoea | 18.58 | 12.21 | 366 | 44403 | 326366 | 29203392 |
Neuropathy peripheral | 18.52 | 12.21 | 51 | 44718 | 70976 | 29458782 |
Vascular purpura | 18.44 | 12.21 | 16 | 44753 | 1387 | 29528371 |
Allergy test positive | 18.39 | 12.21 | 5 | 44764 | 26 | 29529732 |
Diabetes mellitus | 18.24 | 12.21 | 20 | 44749 | 39811 | 29489947 |
Loss of personal independence in daily activities | 17.95 | 12.21 | 8 | 44761 | 25432 | 29504326 |
Shock | 17.91 | 12.21 | 72 | 44697 | 21332 | 29508426 |
Gastrooesophageal reflux disease | 17.80 | 12.21 | 13 | 44756 | 31483 | 29498275 |
Erectile dysfunction | 17.65 | 12.21 | 3 | 44766 | 18006 | 29511752 |
Vanishing bile duct syndrome | 17.55 | 12.21 | 11 | 44758 | 577 | 29529181 |
Hypofibrinogenaemia | 17.50 | 12.21 | 16 | 44753 | 1485 | 29528273 |
Bronchopleural fistula | 17.38 | 12.21 | 10 | 44759 | 448 | 29529310 |
Henoch-Schonlein purpura | 17.28 | 12.21 | 15 | 44754 | 1301 | 29528457 |
Hepatitis fulminant | 17.18 | 12.21 | 24 | 44745 | 3547 | 29526211 |
Morganella infection | 17.12 | 12.21 | 10 | 44759 | 461 | 29529297 |
Gamma-glutamyltransferase increased | 17.10 | 12.21 | 83 | 44686 | 26654 | 29503104 |
Drug eruption | 17.07 | 12.21 | 60 | 44709 | 16681 | 29513077 |
Osteomyelitis fungal | 17.07 | 12.21 | 8 | 44761 | 233 | 29529525 |
ADAMTS13 activity decreased | 17.05 | 12.21 | 6 | 44763 | 81 | 29529677 |
Lymphopenia | 16.94 | 12.21 | 52 | 44717 | 13481 | 29516277 |
Suicide attempt | 16.90 | 12.21 | 16 | 44753 | 34094 | 29495664 |
Encephalopathy | 16.82 | 12.21 | 92 | 44677 | 30951 | 29498807 |
Prothrombin time ratio decreased | 16.81 | 12.21 | 9 | 44760 | 350 | 29529408 |
Cholangitis | 16.78 | 12.21 | 36 | 44733 | 7501 | 29522257 |
Renal papillary necrosis | 16.75 | 12.21 | 7 | 44762 | 154 | 29529604 |
Low birth weight baby | 16.40 | 12.21 | 33 | 44736 | 6575 | 29523183 |
Nail bed bleeding | 16.33 | 12.21 | 5 | 44764 | 42 | 29529716 |
Intentional product misuse | 16.32 | 12.21 | 17 | 44752 | 34644 | 29495114 |
Drug ineffective | 16.30 | 12.21 | 688 | 44081 | 362482 | 29167276 |
Erythema multiforme | 16.21 | 12.21 | 36 | 44733 | 7681 | 29522077 |
Herpes zoster reactivation | 16.20 | 12.21 | 8 | 44761 | 262 | 29529496 |
Shock haemorrhagic | 16.20 | 12.21 | 41 | 44728 | 9510 | 29520248 |
Basal cell carcinoma | 16.17 | 12.21 | 3 | 44766 | 16907 | 29512851 |
Orthostatic hypotension | 16.15 | 12.21 | 7 | 44762 | 22622 | 29507136 |
Intracranial pressure increased | 16.15 | 12.21 | 23 | 44746 | 3462 | 29526296 |
Aggression | 16.11 | 12.21 | 18 | 44751 | 35523 | 29494235 |
Peritoneal dialysis | 16.08 | 12.21 | 10 | 44759 | 517 | 29529241 |
Back pain | 16.05 | 12.21 | 90 | 44679 | 102194 | 29427564 |
Pneumonia bacterial | 15.74 | 12.21 | 40 | 44729 | 9303 | 29520455 |
Coronavirus infection | 15.68 | 12.21 | 22 | 44747 | 3266 | 29526492 |
Carotid artery insufficiency | 15.57 | 12.21 | 4 | 44765 | 16 | 29529742 |
Stomatitis | 15.54 | 12.21 | 20 | 44749 | 37093 | 29492665 |
Chondrocalcinosis | 15.51 | 12.21 | 8 | 44761 | 288 | 29529470 |
Meningitis bacterial | 15.31 | 12.21 | 13 | 44756 | 1094 | 29528664 |
Cerebellar syndrome | 15.27 | 12.21 | 17 | 44752 | 1997 | 29527761 |
Human T-cell lymphotropic virus type I infection | 15.19 | 12.21 | 4 | 44765 | 18 | 29529740 |
Injection site pain | 15.18 | 12.21 | 16 | 44753 | 32430 | 29497328 |
Blood pressure increased | 15.08 | 12.21 | 59 | 44710 | 73744 | 29456014 |
Encephalomalacia | 15.08 | 12.21 | 11 | 44758 | 742 | 29529016 |
Sleep apnoea syndrome | 15.06 | 12.21 | 4 | 44765 | 17595 | 29512163 |
Musculoskeletal pain | 15.04 | 12.21 | 13 | 44756 | 28940 | 29500818 |
Hypoaesthesia | 15.00 | 12.21 | 37 | 44732 | 53430 | 29476328 |
Strongyloidiasis | 14.98 | 12.21 | 18 | 44751 | 2294 | 29527464 |
Psoriasis | 14.96 | 12.21 | 16 | 44753 | 32211 | 29497547 |
Lower respiratory tract infection | 14.89 | 12.21 | 11 | 44758 | 26491 | 29503267 |
Tuberculosis of genitourinary system | 14.84 | 12.21 | 4 | 44765 | 20 | 29529738 |
Unevaluable event | 14.79 | 12.21 | 14 | 44755 | 29837 | 29499921 |
Ocular icterus | 14.76 | 12.21 | 19 | 44750 | 2596 | 29527162 |
Hypovolaemic shock | 14.68 | 12.21 | 30 | 44739 | 6042 | 29523716 |
Red blood cell sedimentation rate decreased | 14.67 | 12.21 | 5 | 44764 | 61 | 29529697 |
Amnesia | 14.64 | 12.21 | 8 | 44761 | 22635 | 29507123 |
Dermatitis exfoliative generalised | 14.64 | 12.21 | 20 | 44749 | 2896 | 29526862 |
Glucose-6-phosphate dehydrogenase deficiency | 14.61 | 12.21 | 6 | 44763 | 126 | 29529632 |
Hypercreatininaemia | 14.57 | 12.21 | 9 | 44760 | 460 | 29529298 |
Antibiotic level below therapeutic | 14.45 | 12.21 | 5 | 44764 | 64 | 29529694 |
Vitamin A deficiency | 14.38 | 12.21 | 4 | 44765 | 23 | 29529735 |
Metastases to heart | 14.31 | 12.21 | 6 | 44763 | 133 | 29529625 |
Contraindicated product administered | 14.11 | 12.21 | 5 | 44764 | 18261 | 29511497 |
Coagulation factor V level decreased | 14.10 | 12.21 | 7 | 44762 | 232 | 29529526 |
Erythema annulare | 14.09 | 12.21 | 4 | 44765 | 25 | 29529733 |
Drug hypersensitivity | 14.09 | 12.21 | 162 | 44607 | 68244 | 29461514 |
Irritability | 14.08 | 12.21 | 8 | 44761 | 22144 | 29507614 |
Dermatitis bullous | 14.07 | 12.21 | 29 | 44740 | 5877 | 29523881 |
Pneumococcal infection | 13.98 | 12.21 | 8 | 44761 | 355 | 29529403 |
Generalised bullous fixed drug eruption | 13.95 | 12.21 | 3 | 44766 | 4 | 29529754 |
White blood cell count decreased | 13.82 | 12.21 | 72 | 44697 | 83290 | 29446468 |
SJS-TEN overlap | 13.75 | 12.21 | 7 | 44762 | 245 | 29529513 |
Bronchial haemorrhage | 13.73 | 12.21 | 10 | 44759 | 673 | 29529085 |
Cholecystitis acute | 13.72 | 12.21 | 27 | 44742 | 5292 | 29524466 |
Meningitis candida | 13.66 | 12.21 | 5 | 44764 | 76 | 29529682 |
Psychotic disorder | 13.44 | 12.21 | 7 | 44762 | 20347 | 29509411 |
COVID-19 treatment | 13.42 | 12.21 | 7 | 44762 | 258 | 29529500 |
Asthma | 13.40 | 12.21 | 19 | 44750 | 33830 | 29495928 |
Hypocoagulable state | 13.36 | 12.21 | 11 | 44758 | 887 | 29528871 |
Urticarial vasculitis | 13.35 | 12.21 | 4 | 44765 | 31 | 29529727 |
Face oedema | 13.32 | 12.21 | 40 | 44729 | 10243 | 29519515 |
Palmar-plantar erythrodysaesthesia syndrome | 13.32 | 12.21 | 3 | 44766 | 14756 | 29515002 |
Distal intestinal obstruction syndrome | 13.32 | 12.21 | 7 | 44762 | 262 | 29529496 |
Ototoxicity | 13.24 | 12.21 | 14 | 44755 | 1551 | 29528207 |
Mechanical urticaria | 13.21 | 12.21 | 5 | 44764 | 84 | 29529674 |
Listeriosis | 13.15 | 12.21 | 11 | 44758 | 907 | 29528851 |
Polycystic liver disease | 13.03 | 12.21 | 4 | 44765 | 34 | 29529724 |
Haemodynamic instability | 13.02 | 12.21 | 34 | 44735 | 8039 | 29521719 |
Dependence on oxygen therapy | 12.95 | 12.21 | 6 | 44763 | 170 | 29529588 |
Altered state of consciousness | 12.91 | 12.21 | 62 | 44707 | 19827 | 29509931 |
Neoplasm progression | 12.90 | 12.21 | 6 | 44763 | 18606 | 29511152 |
Hyperglycaemia | 12.84 | 12.21 | 20 | 44749 | 34267 | 29495491 |
Ureteric obstruction | 12.79 | 12.21 | 12 | 44757 | 1151 | 29528607 |
Influenza like illness | 12.69 | 12.21 | 11 | 44758 | 24459 | 29505299 |
Dry skin | 12.68 | 12.21 | 10 | 44759 | 23297 | 29506461 |
Renal tubular necrosis | 12.66 | 12.21 | 49 | 44720 | 14266 | 29515492 |
Haematuria traumatic | 12.55 | 12.21 | 6 | 44763 | 183 | 29529575 |
Influenza | 12.53 | 12.21 | 28 | 44741 | 41853 | 29487905 |
Hyperthermia | 12.52 | 12.21 | 37 | 44732 | 9393 | 29520365 |
Blood cholesterol increased | 12.51 | 12.21 | 4 | 44765 | 15591 | 29514167 |
Fistula discharge | 12.47 | 12.21 | 8 | 44761 | 437 | 29529321 |
Rash erythematous | 12.43 | 12.21 | 65 | 44704 | 21497 | 29508261 |
Leukopenia | 12.40 | 12.21 | 133 | 44636 | 55070 | 29474688 |
Local anaesthetic systemic toxicity | 12.37 | 12.21 | 6 | 44763 | 189 | 29529569 |
Haemorrhoids thrombosed | 12.37 | 12.21 | 6 | 44763 | 189 | 29529569 |
Cardiac arrest | 12.35 | 12.21 | 190 | 44579 | 85401 | 29444357 |
Fibrous dysplasia of bone | 12.34 | 12.21 | 3 | 44766 | 9 | 29529749 |
Cryptococcosis | 12.33 | 12.21 | 15 | 44754 | 1937 | 29527821 |
Cholestatic liver injury | 12.31 | 12.21 | 14 | 44755 | 1683 | 29528075 |
PO2 decreased | 12.25 | 12.21 | 13 | 44756 | 1446 | 29528312 |
Viral pharyngitis | 12.22 | 12.21 | 5 | 44764 | 104 | 29529654 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug reaction with eosinophilia and systemic symptoms | 949.45 | 11.11 | 676 | 79876 | 53541 | 64364639 |
Off label use | 603.54 | 11.11 | 1943 | 78609 | 630863 | 63787317 |
Pseudocholelithiasis | 517.55 | 11.11 | 91 | 80461 | 0 | 64418180 |
Acute kidney injury | 426.38 | 11.11 | 1379 | 79173 | 447861 | 63970319 |
Acute generalised exanthematous pustulosis | 421.29 | 11.11 | 246 | 80306 | 13812 | 64404368 |
Toxic epidermal necrolysis | 402.07 | 11.11 | 349 | 80203 | 36817 | 64381363 |
Postrenal failure | 394.58 | 11.11 | 100 | 80452 | 474 | 64417706 |
Rash maculo-papular | 385.18 | 11.11 | 378 | 80174 | 46648 | 64371532 |
Jarisch-Herxheimer reaction | 362.52 | 11.11 | 97 | 80455 | 590 | 64417590 |
Eosinophilia | 334.27 | 11.11 | 318 | 80234 | 37758 | 64380422 |
Fatigue | 321.35 | 11.11 | 279 | 80273 | 748451 | 63669729 |
Multiple organ dysfunction syndrome | 318.24 | 11.11 | 503 | 80049 | 100910 | 64317270 |
Cholelithiasis | 283.39 | 11.11 | 316 | 80236 | 45190 | 64372990 |
Cholestasis | 276.70 | 11.11 | 310 | 80242 | 44562 | 64373618 |
Completed suicide | 259.75 | 11.11 | 4 | 80548 | 224410 | 64193770 |
Hepatitis | 255.90 | 11.11 | 300 | 80252 | 45282 | 64372898 |
Agranulocytosis | 249.32 | 11.11 | 272 | 80280 | 37957 | 64380223 |
Pyrexia | 221.77 | 11.11 | 1320 | 79232 | 557324 | 63860856 |
Pain | 219.64 | 11.11 | 221 | 80331 | 553290 | 63864890 |
Haemolytic anaemia | 215.73 | 11.11 | 171 | 80381 | 15882 | 64402298 |
Anaphylactic shock | 206.89 | 11.11 | 221 | 80331 | 30107 | 64388073 |
Joint swelling | 202.70 | 11.11 | 18 | 80534 | 215364 | 64202816 |
Hepatocellular injury | 201.35 | 11.11 | 265 | 80287 | 44970 | 64373210 |
Septic shock | 197.03 | 11.11 | 418 | 80134 | 105019 | 64313161 |
Clostridium difficile colitis | 195.71 | 11.11 | 204 | 80348 | 27019 | 64391161 |
Electrocardiogram QT prolonged | 178.32 | 11.11 | 340 | 80212 | 79108 | 64339072 |
Factor V inhibition | 172.38 | 11.11 | 47 | 80505 | 310 | 64417870 |
Rheumatoid arthritis | 165.21 | 11.11 | 10 | 80542 | 164284 | 64253896 |
Fall | 163.35 | 11.11 | 168 | 80384 | 416658 | 64001522 |
Appendicolith | 157.64 | 11.11 | 80 | 80472 | 3389 | 64414791 |
Drug-induced liver injury | 155.82 | 11.11 | 241 | 80311 | 47402 | 64370778 |
Arthralgia | 155.11 | 11.11 | 195 | 80357 | 442065 | 63976115 |
Toxic encephalopathy | 150.32 | 11.11 | 113 | 80439 | 9702 | 64408478 |
Hypertransaminasaemia | 150.04 | 11.11 | 100 | 80452 | 7091 | 64411089 |
Drug intolerance | 145.40 | 11.11 | 29 | 80523 | 187963 | 64230217 |
Weight increased | 145.33 | 11.11 | 43 | 80509 | 213305 | 64204875 |
Product dose omission issue | 144.58 | 11.11 | 33 | 80519 | 194714 | 64223466 |
Long QT syndrome | 143.65 | 11.11 | 86 | 80466 | 5053 | 64413127 |
Tubulointerstitial nephritis | 143.64 | 11.11 | 185 | 80367 | 30724 | 64387456 |
Dizziness | 140.32 | 11.11 | 200 | 80352 | 429963 | 63988217 |
Drug interaction | 140.27 | 11.11 | 851 | 79701 | 361232 | 64056948 |
Respiratory failure | 137.16 | 11.11 | 478 | 80074 | 160705 | 64257475 |
Headache | 134.74 | 11.11 | 288 | 80264 | 529179 | 63889001 |
Stevens-Johnson syndrome | 134.73 | 11.11 | 189 | 80363 | 34060 | 64384120 |
Arthropathy | 132.68 | 11.11 | 4 | 80548 | 120963 | 64297217 |
Bronchopulmonary aspergillosis | 130.02 | 11.11 | 139 | 80413 | 18946 | 64399234 |
Abdominal discomfort | 129.28 | 11.11 | 34 | 80518 | 182288 | 64235892 |
Pathogen resistance | 118.17 | 11.11 | 109 | 80443 | 12434 | 64405746 |
Alopecia | 117.27 | 11.11 | 31 | 80521 | 165659 | 64252521 |
Pain in extremity | 115.43 | 11.11 | 125 | 80427 | 302960 | 64115220 |
Cardiogenic shock | 113.04 | 11.11 | 169 | 80383 | 32258 | 64385922 |
Death | 112.67 | 11.11 | 275 | 80277 | 482430 | 63935750 |
Nasopharyngitis | 112.53 | 11.11 | 52 | 80500 | 196021 | 64222159 |
Acute respiratory distress syndrome | 110.94 | 11.11 | 185 | 80367 | 38750 | 64379430 |
Synovitis | 109.68 | 11.11 | 3 | 80549 | 99087 | 64319093 |
Therapeutic product effect decreased | 107.50 | 11.11 | 10 | 80542 | 115341 | 64302839 |
Thrombocytopenia | 107.06 | 11.11 | 557 | 79995 | 223244 | 64194936 |
Ureterolithiasis | 106.54 | 11.11 | 60 | 80492 | 3141 | 64415039 |
Drug abuse | 105.35 | 11.11 | 19 | 80533 | 132355 | 64285825 |
Hydronephrosis | 103.57 | 11.11 | 107 | 80445 | 14018 | 64404162 |
Transaminases increased | 102.68 | 11.11 | 193 | 80359 | 44401 | 64373779 |
Insomnia | 102.37 | 11.11 | 60 | 80492 | 197776 | 64220404 |
Haemolysis | 102.20 | 11.11 | 95 | 80457 | 10944 | 64407236 |
Leukocytosis | 101.80 | 11.11 | 175 | 80377 | 37565 | 64380615 |
Peripheral swelling | 100.59 | 11.11 | 69 | 80483 | 209084 | 64209096 |
Hepatitis cholestatic | 99.99 | 11.11 | 98 | 80454 | 12057 | 64406123 |
Pseudomembranous colitis | 99.29 | 11.11 | 67 | 80485 | 4849 | 64413331 |
Anaphylactic reaction | 99.16 | 11.11 | 246 | 80306 | 68418 | 64349762 |
Depression | 98.56 | 11.11 | 53 | 80499 | 183238 | 64234942 |
Immune reconstitution inflammatory syndrome | 97.88 | 11.11 | 98 | 80454 | 12372 | 64405808 |
Sepsis | 90.68 | 11.11 | 544 | 80008 | 229797 | 64188383 |
Contusion | 89.30 | 11.11 | 17 | 80535 | 113948 | 64304232 |
Clostridium difficile infection | 87.63 | 11.11 | 160 | 80392 | 36003 | 64382177 |
Premature delivery | 87.52 | 11.11 | 112 | 80440 | 18477 | 64399703 |
Appendicitis | 87.48 | 11.11 | 96 | 80456 | 13473 | 64404707 |
Alanine aminotransferase increased | 85.32 | 11.11 | 372 | 80180 | 138659 | 64279521 |
Contraindicated product administered | 84.67 | 11.11 | 16 | 80536 | 107813 | 64310367 |
Myocardial infarction | 83.38 | 11.11 | 52 | 80500 | 165769 | 64252411 |
Clostridium test positive | 82.91 | 11.11 | 56 | 80496 | 4059 | 64414121 |
Injection site pain | 80.43 | 11.11 | 20 | 80532 | 111388 | 64306792 |
Choreoathetosis | 79.56 | 11.11 | 38 | 80514 | 1409 | 64416771 |
Neutropenia | 78.95 | 11.11 | 541 | 80011 | 239083 | 64179097 |
Drug resistance | 78.43 | 11.11 | 150 | 80402 | 34952 | 64383228 |
Tachypnoea | 78.03 | 11.11 | 128 | 80424 | 26443 | 64391737 |
Malaise | 76.61 | 11.11 | 247 | 80305 | 396000 | 64022180 |
Toxicity to various agents | 76.42 | 11.11 | 218 | 80334 | 363295 | 64054885 |
Cross sensitivity reaction | 75.54 | 11.11 | 49 | 80503 | 3318 | 64414862 |
Encephalopathy | 73.88 | 11.11 | 200 | 80352 | 58619 | 64359561 |
Status epilepticus | 71.39 | 11.11 | 110 | 80442 | 21553 | 64396627 |
Product use in unapproved indication | 70.02 | 11.11 | 418 | 80134 | 176200 | 64241980 |
Swelling | 69.17 | 11.11 | 59 | 80493 | 160159 | 64258021 |
Hypoxia | 68.57 | 11.11 | 254 | 80298 | 87895 | 64330285 |
Erythema | 67.42 | 11.11 | 432 | 80120 | 186638 | 64231542 |
Drug ineffective for unapproved indication | 67.06 | 11.11 | 131 | 80421 | 31002 | 64387178 |
Nocardiosis | 66.67 | 11.11 | 52 | 80500 | 4715 | 64413465 |
Haemophagocytic lymphohistiocytosis | 66.03 | 11.11 | 95 | 80457 | 17514 | 64400666 |
Disseminated intravascular coagulation | 65.93 | 11.11 | 133 | 80419 | 32215 | 64385965 |
Pneumococcal infection | 65.63 | 11.11 | 28 | 80524 | 793 | 64417387 |
Rash morbilliform | 65.31 | 11.11 | 53 | 80499 | 5088 | 64413092 |
Anuria | 64.90 | 11.11 | 98 | 80454 | 18866 | 64399314 |
Muscle spasms | 64.53 | 11.11 | 49 | 80503 | 140974 | 64277206 |
Torsade de pointes | 64.12 | 11.11 | 93 | 80459 | 17270 | 64400910 |
Sinusitis | 63.89 | 11.11 | 53 | 80499 | 145875 | 64272305 |
Gait disturbance | 63.27 | 11.11 | 73 | 80479 | 172082 | 64246098 |
Wound | 62.99 | 11.11 | 10 | 80542 | 76467 | 64341713 |
Glossodynia | 61.92 | 11.11 | 5 | 80547 | 64691 | 64353489 |
Brain abscess | 61.51 | 11.11 | 47 | 80505 | 4134 | 64414046 |
Encephalitis | 61.17 | 11.11 | 77 | 80475 | 12494 | 64405686 |
Klebsiella infection | 60.92 | 11.11 | 79 | 80473 | 13202 | 64404978 |
Urticaria | 59.24 | 11.11 | 350 | 80202 | 146967 | 64271213 |
Altered state of consciousness | 58.12 | 11.11 | 139 | 80413 | 37763 | 64380417 |
Intentional overdose | 57.87 | 11.11 | 20 | 80532 | 89924 | 64328256 |
Anxiety | 57.63 | 11.11 | 103 | 80449 | 202546 | 64215634 |
Pleocytosis | 57.62 | 11.11 | 28 | 80524 | 1079 | 64417101 |
Lower respiratory tract infection | 57.58 | 11.11 | 23 | 80529 | 94591 | 64323589 |
Cardiac arrest | 57.49 | 11.11 | 359 | 80193 | 153705 | 64264475 |
Pemphigus | 57.25 | 11.11 | 5 | 80547 | 60696 | 64357484 |
Myasthenia gravis crisis | 57.25 | 11.11 | 26 | 80526 | 858 | 64417322 |
Respiratory distress | 56.98 | 11.11 | 169 | 80383 | 52162 | 64366018 |
Enterococcal infection | 56.73 | 11.11 | 78 | 80474 | 13788 | 64404392 |
Injection site erythema | 56.66 | 11.11 | 10 | 80542 | 70790 | 64347390 |
Inflammatory marker increased | 56.58 | 11.11 | 61 | 80491 | 8390 | 64409790 |
Exposure during pregnancy | 56.43 | 11.11 | 219 | 80333 | 77456 | 64340724 |
Systemic lupus erythematosus | 55.88 | 11.11 | 14 | 80538 | 77598 | 64340582 |
Toxic skin eruption | 55.42 | 11.11 | 92 | 80460 | 19192 | 64398988 |
Mobility decreased | 55.38 | 11.11 | 19 | 80533 | 85821 | 64332359 |
Nausea | 55.11 | 11.11 | 673 | 79879 | 785127 | 63633053 |
Liver injury | 53.92 | 11.11 | 117 | 80435 | 29815 | 64388365 |
Cholangitis | 53.89 | 11.11 | 67 | 80485 | 10735 | 64407445 |
Dermatitis bullous | 52.65 | 11.11 | 70 | 80482 | 11984 | 64406196 |
Blood pressure fluctuation | 52.59 | 11.11 | 3 | 80549 | 51868 | 64366312 |
Discomfort | 52.00 | 11.11 | 18 | 80534 | 80860 | 64337320 |
COVID-19 pneumonia | 51.87 | 11.11 | 82 | 80470 | 16422 | 64401758 |
Linear IgA disease | 51.75 | 11.11 | 36 | 80516 | 2738 | 64415442 |
Musculoskeletal stiffness | 51.20 | 11.11 | 47 | 80505 | 123159 | 64295021 |
Ventricular fibrillation | 50.90 | 11.11 | 100 | 80452 | 23760 | 64394420 |
Weight decreased | 49.19 | 11.11 | 187 | 80365 | 285552 | 64132628 |
Enterobacter infection | 48.85 | 11.11 | 39 | 80513 | 3657 | 64414523 |
Feeling abnormal | 48.71 | 11.11 | 57 | 80495 | 133545 | 64284635 |
Bile duct stone | 48.33 | 11.11 | 44 | 80508 | 4934 | 64413246 |
Stomatitis | 47.73 | 11.11 | 40 | 80512 | 109565 | 64308615 |
Musculoskeletal pain | 47.48 | 11.11 | 21 | 80531 | 81273 | 64336907 |
Hepatic function abnormal | 47.26 | 11.11 | 182 | 80370 | 64131 | 64354049 |
Neurotoxicity | 46.96 | 11.11 | 105 | 80447 | 27299 | 64390881 |
Dermatitis exfoliative | 46.58 | 11.11 | 61 | 80491 | 10291 | 64407889 |
Cyanosis | 46.23 | 11.11 | 92 | 80460 | 22063 | 64396117 |
Blood pressure increased | 46.15 | 11.11 | 91 | 80461 | 172461 | 64245719 |
Aspartate aminotransferase increased | 45.85 | 11.11 | 281 | 80271 | 119507 | 64298673 |
Balance disorder | 45.48 | 11.11 | 24 | 80528 | 83902 | 64334278 |
Oliguria | 45.22 | 11.11 | 72 | 80480 | 14504 | 64403676 |
Jaundice | 44.82 | 11.11 | 148 | 80404 | 48364 | 64369816 |
Trichosporon infection | 44.74 | 11.11 | 22 | 80530 | 870 | 64417310 |
Hospitalisation | 44.60 | 11.11 | 19 | 80533 | 75188 | 64342992 |
Hypoaesthesia | 43.93 | 11.11 | 66 | 80486 | 139042 | 64279138 |
Migraine | 43.80 | 11.11 | 12 | 80540 | 62665 | 64355515 |
Hypertension | 43.76 | 11.11 | 171 | 80381 | 259090 | 64159090 |
Injection site reaction | 43.58 | 11.11 | 4 | 80548 | 46660 | 64371520 |
Nosocomial infection | 42.88 | 11.11 | 31 | 80521 | 2506 | 64415674 |
Abdominal pain upper | 42.87 | 11.11 | 97 | 80455 | 174933 | 64243247 |
Fixed eruption | 42.59 | 11.11 | 29 | 80523 | 2130 | 64416050 |
Symmetrical drug-related intertriginous and flexural exanthema | 42.55 | 11.11 | 19 | 80533 | 602 | 64417578 |
Blood cholesterol increased | 42.48 | 11.11 | 6 | 80546 | 50060 | 64368120 |
Inappropriate schedule of product administration | 42.29 | 11.11 | 32 | 80520 | 92254 | 64325926 |
Back pain | 41.59 | 11.11 | 166 | 80386 | 250005 | 64168175 |
Acute respiratory failure | 41.46 | 11.11 | 147 | 80405 | 49787 | 64368393 |
Tachycardia | 41.34 | 11.11 | 324 | 80228 | 149255 | 64268925 |
Psoriasis | 41.12 | 11.11 | 19 | 80533 | 71684 | 64346496 |
Osteoarthritis | 40.88 | 11.11 | 14 | 80538 | 63322 | 64354858 |
Endocarditis | 40.26 | 11.11 | 54 | 80498 | 9324 | 64408856 |
Hypofibrinogenaemia | 40.19 | 11.11 | 26 | 80526 | 1752 | 64416428 |
Renal failure | 39.93 | 11.11 | 374 | 80178 | 181314 | 64236866 |
Condition aggravated | 39.92 | 11.11 | 670 | 79882 | 371756 | 64046424 |
Dry mouth | 39.62 | 11.11 | 13 | 80539 | 60405 | 64357775 |
Infusion related reaction | 39.59 | 11.11 | 92 | 80460 | 164375 | 64253805 |
Acinetobacter infection | 39.51 | 11.11 | 29 | 80523 | 2400 | 64415780 |
Cataract | 39.40 | 11.11 | 8 | 80544 | 51254 | 64366926 |
Gastrooesophageal reflux disease | 39.18 | 11.11 | 28 | 80524 | 83115 | 64335065 |
Pruritus | 39.15 | 11.11 | 577 | 79975 | 311823 | 64106357 |
Leukopenia | 39.05 | 11.11 | 238 | 80314 | 101004 | 64317176 |
Pancytopenia | 38.82 | 11.11 | 309 | 80243 | 143000 | 64275180 |
Hepatomegaly | 38.76 | 11.11 | 73 | 80479 | 16809 | 64401371 |
Rash | 38.76 | 11.11 | 795 | 79757 | 457754 | 63960426 |
Hepatitis acute | 38.64 | 11.11 | 64 | 80488 | 13325 | 64404855 |
Liver function test increased | 38.57 | 11.11 | 105 | 80447 | 30865 | 64387315 |
Shock | 38.35 | 11.11 | 120 | 80432 | 38120 | 64380060 |
Erythema nodosum | 38.11 | 11.11 | 35 | 80517 | 3969 | 64414211 |
Influenza B virus test positive | 38.02 | 11.11 | 15 | 80537 | 346 | 64417834 |
Renal papillary necrosis | 37.90 | 11.11 | 15 | 80537 | 349 | 64417831 |
Wrong technique in product usage process | 37.60 | 11.11 | 17 | 80535 | 64957 | 64353223 |
Suicidal ideation | 37.60 | 11.11 | 18 | 80534 | 66524 | 64351656 |
Cardiac failure congestive | 37.44 | 11.11 | 66 | 80486 | 130514 | 64287666 |
Haemodynamic instability | 37.42 | 11.11 | 67 | 80485 | 14845 | 64403335 |
Hepatitis toxic | 37.17 | 11.11 | 36 | 80516 | 4364 | 64413816 |
Coagulation factor decreased | 37.12 | 11.11 | 12 | 80540 | 151 | 64418029 |
Cholecystitis | 36.79 | 11.11 | 78 | 80474 | 19558 | 64398622 |
Splenomegaly | 36.78 | 11.11 | 74 | 80478 | 17887 | 64400293 |
Blood glucose increased | 36.65 | 11.11 | 41 | 80511 | 98032 | 64320148 |
Morganella infection | 36.61 | 11.11 | 20 | 80532 | 986 | 64417194 |
Alcohol intolerance | 36.61 | 11.11 | 15 | 80537 | 383 | 64417797 |
Bronchopleural fistula | 36.55 | 11.11 | 17 | 80535 | 593 | 64417587 |
Arthritis | 35.99 | 11.11 | 31 | 80521 | 83783 | 64334397 |
Ill-defined disorder | 35.74 | 11.11 | 6 | 80546 | 44046 | 64374134 |
Disseminated cryptococcosis | 35.63 | 11.11 | 23 | 80529 | 1544 | 64416636 |
Metabolic acidosis | 35.51 | 11.11 | 179 | 80373 | 70779 | 64347401 |
Stenotrophomonas infection | 35.47 | 11.11 | 30 | 80522 | 3050 | 64415130 |
Escherichia infection | 35.34 | 11.11 | 66 | 80486 | 15102 | 64403078 |
Acute hepatic failure | 35.02 | 11.11 | 91 | 80461 | 26021 | 64392159 |
Drug eruption | 34.96 | 11.11 | 112 | 80440 | 36024 | 64382156 |
Renal tubular necrosis | 34.88 | 11.11 | 82 | 80470 | 22028 | 64396152 |
Procalcitonin increased | 34.46 | 11.11 | 27 | 80525 | 2464 | 64415716 |
Ascites | 34.33 | 11.11 | 161 | 80391 | 61840 | 64356340 |
Mucormycosis | 34.19 | 11.11 | 44 | 80508 | 7297 | 64410883 |
Cryptococcal meningoencephalitis | 34.03 | 11.11 | 12 | 80540 | 200 | 64417980 |
Kounis syndrome | 33.89 | 11.11 | 29 | 80523 | 2996 | 64415184 |
SJS-TEN overlap | 33.87 | 11.11 | 15 | 80537 | 466 | 64417714 |
Hepatic cytolysis | 33.82 | 11.11 | 62 | 80490 | 13987 | 64404193 |
Erythema multiforme | 33.73 | 11.11 | 66 | 80486 | 15635 | 64402545 |
Palpitations | 33.54 | 11.11 | 49 | 80503 | 104439 | 64313741 |
Vision blurred | 33.49 | 11.11 | 38 | 80514 | 90278 | 64327902 |
Ureteral disorder | 33.17 | 11.11 | 15 | 80537 | 490 | 64417690 |
Memory impairment | 32.93 | 11.11 | 35 | 80517 | 85647 | 64332533 |
Type IV hypersensitivity reaction | 32.74 | 11.11 | 30 | 80522 | 3392 | 64414788 |
Cerebrovascular accident | 32.28 | 11.11 | 78 | 80474 | 137505 | 64280675 |
Hypercreatininaemia | 31.88 | 11.11 | 17 | 80535 | 798 | 64417382 |
Candida infection | 31.88 | 11.11 | 99 | 80453 | 31320 | 64386860 |
Coronary artery disease | 31.69 | 11.11 | 18 | 80534 | 60415 | 64357765 |
Dermatitis exfoliative generalised | 31.63 | 11.11 | 38 | 80514 | 5878 | 64412302 |
No adverse event | 30.86 | 11.11 | 92 | 80460 | 28469 | 64389711 |
Alveolitis | 30.80 | 11.11 | 30 | 80522 | 3662 | 64414518 |
Autoimmune haemolytic anaemia | 30.76 | 11.11 | 41 | 80511 | 7035 | 64411145 |
Orthostatic hypotension | 30.74 | 11.11 | 10 | 80542 | 46728 | 64371452 |
Intentional product misuse | 30.72 | 11.11 | 27 | 80525 | 72268 | 64345912 |
Injection site swelling | 30.67 | 11.11 | 7 | 80545 | 41346 | 64376834 |
Multiple sclerosis relapse | 30.43 | 11.11 | 7 | 80545 | 41128 | 64377052 |
Unresponsive to stimuli | 30.24 | 11.11 | 134 | 80418 | 50259 | 64367921 |
Pyuria | 30.23 | 11.11 | 23 | 80529 | 2010 | 64416170 |
Gamma-glutamyltransferase increased | 29.87 | 11.11 | 130 | 80422 | 48380 | 64369800 |
Chest pain | 29.65 | 11.11 | 173 | 80379 | 235807 | 64182373 |
Dyspepsia | 29.55 | 11.11 | 34 | 80518 | 80278 | 64337902 |
Helicobacter infection | 29.46 | 11.11 | 6 | 80546 | 38356 | 64379824 |
Malignant mesenteric neoplasm | 29.31 | 11.11 | 8 | 80544 | 53 | 64418127 |
Cholestatic liver injury | 29.03 | 11.11 | 29 | 80523 | 3650 | 64414530 |
Rash erythematous | 28.94 | 11.11 | 129 | 80423 | 48504 | 64369676 |
Injection site pruritus | 28.87 | 11.11 | 6 | 80546 | 37820 | 64380360 |
Drug effective for unapproved indication | 28.84 | 11.11 | 29 | 80523 | 3679 | 64414501 |
CSF measles antibody positive | 28.81 | 11.11 | 8 | 80544 | 57 | 64418123 |
Herpes zoster | 28.62 | 11.11 | 34 | 80518 | 79153 | 64339027 |
Anti factor V antibody | 28.43 | 11.11 | 5 | 80547 | 0 | 64418180 |
Rubella antibody positive | 28.33 | 11.11 | 8 | 80544 | 61 | 64418119 |
Organic brain syndrome | 28.18 | 11.11 | 13 | 80539 | 445 | 64417735 |
Fluid retention | 28.17 | 11.11 | 20 | 80532 | 59586 | 64358594 |
Portal fibrosis | 27.96 | 11.11 | 14 | 80538 | 576 | 64417604 |
Type I hypersensitivity | 27.88 | 11.11 | 28 | 80524 | 3546 | 64414634 |
Muscle abscess | 27.63 | 11.11 | 16 | 80536 | 883 | 64417297 |
Influenza like illness | 27.50 | 11.11 | 22 | 80530 | 61680 | 64356500 |
Aspergillus infection | 27.22 | 11.11 | 62 | 80490 | 16317 | 64401863 |
Asthenia | 27.14 | 11.11 | 374 | 80178 | 427670 | 63990510 |
Pericarditis | 26.98 | 11.11 | 23 | 80529 | 62493 | 64355687 |
Nasal congestion | 26.93 | 11.11 | 21 | 80531 | 59637 | 64358543 |
Angioedema | 26.86 | 11.11 | 150 | 80402 | 61671 | 64356509 |
International normalised ratio increased | 26.76 | 11.11 | 180 | 80372 | 78987 | 64339193 |
Janeway lesion | 26.62 | 11.11 | 6 | 80546 | 15 | 64418165 |
Fibromyalgia | 26.59 | 11.11 | 6 | 80546 | 35725 | 64382455 |
Flank pain | 26.59 | 11.11 | 61 | 80491 | 16128 | 64402052 |
Hepatosplenomegaly | 26.43 | 11.11 | 33 | 80519 | 5310 | 64412870 |
Hyperferritinaemia | 26.40 | 11.11 | 13 | 80539 | 516 | 64417664 |
Crystalluria | 25.99 | 11.11 | 15 | 80537 | 823 | 64417357 |
Diarrhoea | 25.95 | 11.11 | 696 | 79856 | 722008 | 63696172 |
Leukaemoid reaction | 25.80 | 11.11 | 11 | 80541 | 311 | 64417869 |
Systemic inflammatory response syndrome | 25.70 | 11.11 | 46 | 80506 | 10189 | 64407991 |
Bacterial pericarditis | 25.69 | 11.11 | 7 | 80545 | 46 | 64418134 |
COVID-19 treatment | 25.37 | 11.11 | 12 | 80540 | 435 | 64417745 |
Peritoneal dialysis | 25.26 | 11.11 | 14 | 80538 | 710 | 64417470 |
Loss of personal independence in daily activities | 25.25 | 11.11 | 32 | 80520 | 72422 | 64345758 |
Type 2 diabetes mellitus | 24.75 | 11.11 | 6 | 80546 | 34014 | 64384166 |
Localised infection | 24.71 | 11.11 | 4 | 80548 | 30157 | 64388023 |
Ureteric obstruction | 24.68 | 11.11 | 22 | 80530 | 2400 | 64415780 |
Folliculitis | 24.61 | 11.11 | 4 | 80548 | 30073 | 64388107 |
Otitis media acute | 24.58 | 11.11 | 16 | 80536 | 1090 | 64417090 |
Dry skin | 24.40 | 11.11 | 17 | 80535 | 51144 | 64367036 |
Intervertebral discitis | 24.36 | 11.11 | 27 | 80525 | 3830 | 64414350 |
Septic pulmonary embolism | 24.11 | 11.11 | 6 | 80546 | 26 | 64418154 |
Jejunal ulcer perforation | 24.10 | 11.11 | 8 | 80544 | 110 | 64418070 |
Suicide attempt | 24.08 | 11.11 | 32 | 80520 | 70975 | 64347205 |
Purpura | 24.05 | 11.11 | 61 | 80491 | 17185 | 64400995 |
Nervousness | 24.03 | 11.11 | 4 | 80548 | 29552 | 64388628 |
Therapeutic product effect incomplete | 24.01 | 11.11 | 59 | 80493 | 103423 | 64314757 |
Psoriatic arthropathy | 24.00 | 11.11 | 12 | 80540 | 43269 | 64374911 |
Coagulopathy | 23.99 | 11.11 | 91 | 80461 | 31829 | 64386351 |
Laryngeal stenosis | 23.85 | 11.11 | 14 | 80538 | 793 | 64417387 |
Interleukin-2 receptor increased | 23.82 | 11.11 | 9 | 80543 | 184 | 64417996 |
Hyperthermia | 23.80 | 11.11 | 57 | 80495 | 15493 | 64402687 |
Hepatitis fulminant | 23.74 | 11.11 | 34 | 80518 | 6240 | 64411940 |
Gastric disorder | 23.63 | 11.11 | 4 | 80548 | 29193 | 64388987 |
Oropharyngeal pain | 23.63 | 11.11 | 47 | 80505 | 88820 | 64329360 |
Visual impairment | 23.51 | 11.11 | 35 | 80517 | 74042 | 64344138 |
Cholecystitis acute | 23.49 | 11.11 | 47 | 80505 | 11313 | 64406867 |
Blood alkaline phosphatase increased | 23.43 | 11.11 | 135 | 80417 | 56144 | 64362036 |
Transient ischaemic attack | 23.40 | 11.11 | 13 | 80539 | 44169 | 64374011 |
Adverse event | 23.37 | 11.11 | 10 | 80542 | 39479 | 64378701 |
Sphincter of Oddi dysfunction | 23.33 | 11.11 | 11 | 80541 | 396 | 64417784 |
Meningitis bacterial | 23.32 | 11.11 | 21 | 80531 | 2322 | 64415858 |
Calculus urinary | 23.28 | 11.11 | 19 | 80533 | 1838 | 64416342 |
COVID-19 | 23.16 | 11.11 | 150 | 80402 | 64990 | 64353190 |
Pneumonia bacterial | 22.89 | 11.11 | 55 | 80497 | 14980 | 64403200 |
Blood brain barrier defect | 22.87 | 11.11 | 8 | 80544 | 130 | 64418050 |
Procalcitonin abnormal | 22.75 | 11.11 | 10 | 80542 | 305 | 64417875 |
Pelvic inflammatory disease | 22.71 | 11.11 | 16 | 80536 | 1242 | 64416938 |
Neck pain | 22.69 | 11.11 | 26 | 80526 | 61507 | 64356673 |
Hyperbilirubinaemia | 22.62 | 11.11 | 68 | 80484 | 21137 | 64397043 |
Cholangitis acute | 22.59 | 11.11 | 16 | 80536 | 1252 | 64416928 |
Product use issue | 22.54 | 11.11 | 105 | 80447 | 151610 | 64266570 |
Blood creatinine increased | 22.49 | 11.11 | 264 | 80288 | 135518 | 64282662 |
Lip oedema | 22.46 | 11.11 | 30 | 80522 | 5159 | 64413021 |
Normocytic anaemia | 22.42 | 11.11 | 24 | 80528 | 3275 | 64414905 |
Face oedema | 22.38 | 11.11 | 75 | 80477 | 24686 | 64393494 |
Eastern Cooperative Oncology Group performance status | 22.35 | 11.11 | 6 | 80546 | 37 | 64418143 |
Sleep apnoea syndrome | 22.22 | 11.11 | 5 | 80547 | 29827 | 64388353 |
Hypoalbuminaemia | 22.08 | 11.11 | 60 | 80492 | 17614 | 64400566 |
Cerebral cyst | 22.02 | 11.11 | 10 | 80542 | 330 | 64417850 |
Weber tuning fork test abnormal | 21.96 | 11.11 | 7 | 80545 | 84 | 64418096 |
Strongyloidiasis | 21.92 | 11.11 | 23 | 80529 | 3067 | 64415113 |
Maternal exposure during pregnancy | 21.86 | 11.11 | 199 | 80353 | 95685 | 64322495 |
Fibrin D dimer increased | 21.79 | 11.11 | 34 | 80518 | 6731 | 64411449 |
Pulmonary physical examination abnormal | 21.78 | 11.11 | 5 | 80547 | 14 | 64418166 |
Gastroenteritis clostridial | 21.63 | 11.11 | 13 | 80539 | 769 | 64417411 |
Factor V deficiency | 21.59 | 11.11 | 7 | 80545 | 89 | 64418091 |
Lymphadenopathy | 21.44 | 11.11 | 115 | 80437 | 46571 | 64371609 |
Corynebacterium infection | 21.44 | 11.11 | 14 | 80538 | 959 | 64417221 |
Basal cell carcinoma | 21.36 | 11.11 | 6 | 80546 | 30832 | 64387348 |
Omental necrosis | 21.34 | 11.11 | 6 | 80546 | 45 | 64418135 |
Acquired haemophilia | 21.21 | 11.11 | 17 | 80535 | 1603 | 64416577 |
Hyperlactacidaemia | 20.95 | 11.11 | 28 | 80524 | 4816 | 64413364 |
Gastrointestinal disorder | 20.92 | 11.11 | 51 | 80501 | 89658 | 64328522 |
Osteonecrosis of jaw | 20.68 | 11.11 | 12 | 80540 | 39813 | 64378367 |
Neutrophilia | 20.67 | 11.11 | 33 | 80519 | 6661 | 64411519 |
Vitamin K deficiency | 20.65 | 11.11 | 12 | 80540 | 667 | 64417513 |
Diabetes mellitus | 20.53 | 11.11 | 32 | 80520 | 66442 | 64351738 |
Surgery | 20.48 | 11.11 | 5 | 80547 | 28208 | 64389972 |
Antinuclear antibody negative | 20.41 | 11.11 | 5 | 80547 | 20 | 64418160 |
Depressed mood | 20.40 | 11.11 | 13 | 80539 | 40999 | 64377181 |
Neoplasm progression | 20.36 | 11.11 | 13 | 80539 | 40951 | 64377229 |
Serum sickness-like reaction | 20.20 | 11.11 | 11 | 80541 | 539 | 64417641 |
Angina pectoris | 20.18 | 11.11 | 16 | 80536 | 45065 | 64373115 |
Drug ineffective | 20.13 | 11.11 | 1260 | 79292 | 838987 | 63579193 |
Vascular purpura | 19.90 | 11.11 | 20 | 80532 | 2536 | 64415644 |
CSF protein increased | 19.82 | 11.11 | 14 | 80538 | 1091 | 64417089 |
Pyelonephritis acute | 19.69 | 11.11 | 28 | 80524 | 5106 | 64413074 |
Liver transplant failure | 19.67 | 11.11 | 7 | 80545 | 120 | 64418060 |
Device related sepsis | 19.60 | 11.11 | 28 | 80524 | 5127 | 64413053 |
Encephalitis brain stem | 19.50 | 11.11 | 8 | 80544 | 205 | 64417975 |
Neuropathy peripheral | 19.49 | 11.11 | 78 | 80474 | 117447 | 64300733 |
Nephropathy toxic | 19.48 | 11.11 | 57 | 80495 | 17457 | 64400723 |
Bacteriuria | 19.41 | 11.11 | 13 | 80539 | 929 | 64417251 |
Hepatitis infectious mononucleosis | 19.25 | 11.11 | 7 | 80545 | 128 | 64418052 |
Hypocoagulable state | 19.22 | 11.11 | 17 | 80535 | 1836 | 64416344 |
Sleep disorder | 19.16 | 11.11 | 28 | 80524 | 59681 | 64358499 |
Iris transillumination defect | 19.10 | 11.11 | 7 | 80545 | 131 | 64418049 |
Antibiotic associated colitis | 19.09 | 11.11 | 4 | 80548 | 6 | 64418174 |
Thunderclap headache | 19.04 | 11.11 | 8 | 80544 | 218 | 64417962 |
Bronchospasm | 19.01 | 11.11 | 65 | 80487 | 21617 | 64396563 |
Joint injury | 18.89 | 11.11 | 3 | 80549 | 22944 | 64395236 |
Pain in jaw | 18.84 | 11.11 | 14 | 80538 | 40741 | 64377439 |
Infective chondritis | 18.74 | 11.11 | 5 | 80547 | 30 | 64418150 |
Henoch-Schonlein purpura | 18.54 | 11.11 | 18 | 80534 | 2188 | 64415992 |
Megacolon | 18.48 | 11.11 | 21 | 80531 | 3061 | 64415119 |
Relapsing fever | 18.42 | 11.11 | 9 | 80543 | 351 | 64417829 |
Dysgeusia | 18.32 | 11.11 | 19 | 80533 | 47028 | 64371152 |
Tooth disorder | 18.28 | 11.11 | 3 | 80549 | 22399 | 64395781 |
Sedation | 18.21 | 11.11 | 15 | 80537 | 41447 | 64376733 |
Flatulence | 18.17 | 11.11 | 11 | 80541 | 35655 | 64382525 |
Tracheobronchitis | 18.10 | 11.11 | 16 | 80536 | 1726 | 64416454 |
Pyelonephritis | 18.07 | 11.11 | 55 | 80497 | 17211 | 64400969 |
Metastases to stomach | 18.02 | 11.11 | 8 | 80544 | 250 | 64417930 |
Hypokalaemia | 18.01 | 11.11 | 232 | 80320 | 121671 | 64296509 |
Impaired healing | 17.84 | 11.11 | 30 | 80522 | 60443 | 64357737 |
Pneumococcal sepsis | 17.75 | 11.11 | 14 | 80538 | 1290 | 64416890 |
Postpartum sepsis | 17.75 | 11.11 | 4 | 80548 | 10 | 64418170 |
Dry eye | 17.74 | 11.11 | 7 | 80545 | 29012 | 64389168 |
Hyperamylasaemia | 17.65 | 11.11 | 12 | 80540 | 879 | 64417301 |
Eosinophilic pneumonia | 17.61 | 11.11 | 25 | 80527 | 4552 | 64413628 |
Lymphopenia | 17.54 | 11.11 | 71 | 80481 | 25586 | 64392594 |
Osteomyelitis fungal | 17.53 | 11.11 | 8 | 80544 | 267 | 64417913 |
Influenza | 17.48 | 11.11 | 71 | 80481 | 106460 | 64311720 |
Haemostasis | 17.45 | 11.11 | 8 | 80544 | 270 | 64417910 |
Meningism | 17.42 | 11.11 | 10 | 80542 | 543 | 64417637 |
Thrombosis | 17.40 | 11.11 | 39 | 80513 | 70603 | 64347577 |
Veillonella infection | 17.39 | 11.11 | 5 | 80547 | 41 | 64418139 |
Hyponatraemia | 17.38 | 11.11 | 271 | 80281 | 148068 | 64270112 |
Drug dependence | 17.35 | 11.11 | 10 | 80542 | 33302 | 64384878 |
Dyspnoea | 17.31 | 11.11 | 728 | 79824 | 717946 | 63700234 |
Antimicrobial susceptibility test resistant | 17.31 | 11.11 | 8 | 80544 | 275 | 64417905 |
Pneumonia necrotising | 17.27 | 11.11 | 12 | 80540 | 911 | 64417269 |
Dyspnoea exertional | 17.13 | 11.11 | 42 | 80510 | 73688 | 64344492 |
Hip arthroplasty | 17.11 | 11.11 | 3 | 80549 | 21348 | 64396832 |
Renal impairment | 17.11 | 11.11 | 250 | 80302 | 134767 | 64283413 |
Macule | 17.11 | 11.11 | 18 | 80534 | 2408 | 64415772 |
Blood pressure systolic increased | 17.06 | 11.11 | 22 | 80530 | 49431 | 64368749 |
Red blood cell agglutination | 17.06 | 11.11 | 3 | 80549 | 0 | 64418180 |
Hyperpyrexia | 17.03 | 11.11 | 26 | 80526 | 5051 | 64413129 |
Intracranial pressure increased | 17.02 | 11.11 | 31 | 80521 | 6958 | 64411222 |
Head injury | 16.91 | 11.11 | 10 | 80542 | 32832 | 64385348 |
Pancreatitis acute | 16.67 | 11.11 | 101 | 80451 | 42754 | 64375426 |
Decreased appetite | 16.66 | 11.11 | 249 | 80303 | 281040 | 64137140 |
Bone pain | 16.58 | 11.11 | 21 | 80531 | 47551 | 64370629 |
Hypersensitivity vasculitis | 16.48 | 11.11 | 30 | 80522 | 6731 | 64411449 |
Carotid artery insufficiency | 16.33 | 11.11 | 4 | 80548 | 16 | 64418164 |
Guillain-Barre syndrome | 16.28 | 11.11 | 32 | 80520 | 7603 | 64410577 |
Obesity | 16.24 | 11.11 | 3 | 80549 | 20559 | 64397621 |
Liver disorder | 16.09 | 11.11 | 118 | 80434 | 53233 | 64364947 |
Syncope | 16.05 | 11.11 | 123 | 80429 | 157512 | 64260668 |
Partial seizures | 16.04 | 11.11 | 31 | 80521 | 7276 | 64410904 |
Joint stiffness | 16.02 | 11.11 | 9 | 80543 | 30395 | 64387785 |
Overdose | 16.02 | 11.11 | 125 | 80427 | 159441 | 64258739 |
Meningitis aseptic | 16.01 | 11.11 | 27 | 80525 | 5703 | 64412477 |
Hypertriglyceridaemia | 16.01 | 11.11 | 40 | 80512 | 11165 | 64407015 |
Viral infection | 15.96 | 11.11 | 13 | 80539 | 36127 | 64382053 |
Sciatica | 15.91 | 11.11 | 3 | 80549 | 20261 | 64397919 |
Vanishing bile duct syndrome | 15.87 | 11.11 | 13 | 80539 | 1264 | 64416916 |
Cerebellar syndrome | 15.87 | 11.11 | 25 | 80527 | 4991 | 64413189 |
Abdominal wall haematoma | 15.81 | 11.11 | 23 | 80529 | 4282 | 64413898 |
Pulmonary necrosis | 15.74 | 11.11 | 9 | 80543 | 485 | 64417695 |
Dehydration | 15.71 | 11.11 | 184 | 80368 | 216579 | 64201601 |
Myopathy toxic | 15.65 | 11.11 | 11 | 80541 | 850 | 64417330 |
Heart rate decreased | 15.62 | 11.11 | 28 | 80524 | 55039 | 64363141 |
Empyema | 15.57 | 11.11 | 21 | 80531 | 3644 | 64414536 |
Ocular icterus | 15.56 | 11.11 | 25 | 80527 | 5073 | 64413107 |
Somnolence | 15.49 | 11.11 | 171 | 80381 | 203474 | 64214706 |
Ear pain | 15.47 | 11.11 | 6 | 80546 | 25130 | 64393050 |
Delirium | 15.46 | 11.11 | 143 | 80409 | 69051 | 64349129 |
Coronavirus infection | 15.38 | 11.11 | 26 | 80526 | 5504 | 64412676 |
Endocarditis bacterial | 15.30 | 11.11 | 13 | 80539 | 1330 | 64416850 |
Muscle injury | 15.16 | 11.11 | 7 | 80545 | 26430 | 64391750 |
Amnesia | 15.13 | 11.11 | 23 | 80529 | 48246 | 64369934 |
Accidental exposure to product | 15.09 | 11.11 | 7 | 80545 | 26357 | 64391823 |
Normal newborn | 15.08 | 11.11 | 26 | 80526 | 5591 | 64412589 |
Hypovolaemic shock | 15.04 | 11.11 | 37 | 80515 | 10229 | 64407951 |
Blood fibrinogen increased | 14.99 | 11.11 | 14 | 80538 | 1622 | 64416558 |
Diabetes insipidus | 14.95 | 11.11 | 23 | 80529 | 4498 | 64413682 |
Respiratory acidosis | 14.95 | 11.11 | 36 | 80516 | 9819 | 64408361 |
Central nervous system vasculitis | 14.88 | 11.11 | 12 | 80540 | 1142 | 64417038 |
Red blood cell schistocytes present | 14.84 | 11.11 | 9 | 80543 | 541 | 64417639 |
Hypotension | 14.82 | 11.11 | 599 | 79953 | 380375 | 64037805 |
Haemodialysis | 14.80 | 11.11 | 51 | 80501 | 17026 | 64401154 |
Laryngeal mass | 14.79 | 11.11 | 5 | 80547 | 73 | 64418107 |
Multiple-drug resistance | 14.78 | 11.11 | 28 | 80524 | 6474 | 64411706 |
Lung consolidation | 14.75 | 11.11 | 31 | 80521 | 7727 | 64410453 |
Antibiotic level below therapeutic | 14.73 | 11.11 | 5 | 80547 | 74 | 64418106 |
Brain herniation | 14.69 | 11.11 | 28 | 80524 | 6505 | 64411675 |
Respiratory disorder | 14.62 | 11.11 | 86 | 80466 | 36025 | 64382155 |
Injection site haemorrhage | 14.60 | 11.11 | 6 | 80546 | 24272 | 64393908 |
Incorrect dose administered | 14.60 | 11.11 | 34 | 80518 | 60731 | 64357449 |
Psychotic disorder | 14.58 | 11.11 | 13 | 80539 | 34565 | 64383615 |
Endotracheal intubation | 14.58 | 11.11 | 21 | 80531 | 3874 | 64414306 |
ADAMTS13 activity decreased | 14.58 | 11.11 | 6 | 80546 | 155 | 64418025 |
Fungal peritonitis | 14.47 | 11.11 | 11 | 80541 | 960 | 64417220 |
Pneumonia pneumococcal | 14.46 | 11.11 | 19 | 80533 | 3215 | 64414965 |
Prothrombin time ratio decreased | 14.34 | 11.11 | 10 | 80542 | 763 | 64417417 |
Tuberculosis of genitourinary system | 14.34 | 11.11 | 4 | 80548 | 29 | 64418151 |
Haemorrhoids | 14.33 | 11.11 | 6 | 80546 | 23995 | 64394185 |
Infective spondylitis | 14.32 | 11.11 | 8 | 80544 | 412 | 64417768 |
Blood pressure diastolic decreased | 14.27 | 11.11 | 5 | 80547 | 22296 | 64395884 |
Tubulointerstitial nephritis and uveitis syndrome | 14.23 | 11.11 | 7 | 80545 | 277 | 64417903 |
Mixed liver injury | 14.23 | 11.11 | 25 | 80527 | 5456 | 64412724 |
Rash macular | 14.22 | 11.11 | 63 | 80489 | 23622 | 64394558 |
Metastases to bone | 14.11 | 11.11 | 4 | 80548 | 20431 | 64397749 |
Septic embolus | 14.11 | 11.11 | 14 | 80538 | 1748 | 64416432 |
Muscular weakness | 14.10 | 11.11 | 97 | 80455 | 127241 | 64290939 |
Pneumonia staphylococcal | 13.99 | 11.11 | 22 | 80530 | 4384 | 64413796 |
Bone marrow failure | 13.86 | 11.11 | 105 | 80447 | 47847 | 64370333 |
Transverse sinus thrombosis | 13.85 | 11.11 | 9 | 80543 | 611 | 64417569 |
Limb injury | 13.83 | 11.11 | 6 | 80546 | 23499 | 64394681 |
Rash pustular | 13.82 | 11.11 | 35 | 80517 | 9850 | 64408330 |
Lymphocyte transformation test positive | 13.78 | 11.11 | 4 | 80548 | 34 | 64418146 |
Hemianopia | 13.77 | 11.11 | 13 | 80539 | 1526 | 64416654 |
Post treatment Lyme disease syndrome | 13.77 | 11.11 | 3 | 80549 | 6 | 64418174 |
Dry gangrene | 13.73 | 11.11 | 10 | 80542 | 818 | 64417362 |
Pseudophaeochromocytoma | 13.72 | 11.11 | 5 | 80547 | 92 | 64418088 |
Haematuria traumatic | 13.62 | 11.11 | 6 | 80546 | 184 | 64417996 |
Foot fracture | 13.61 | 11.11 | 3 | 80549 | 18154 | 64400026 |
Cardiac disorder | 13.60 | 11.11 | 31 | 80521 | 55785 | 64362395 |
Cardiac valve abscess | 13.58 | 11.11 | 4 | 80548 | 36 | 64418144 |
Staphylococcal infection | 13.56 | 11.11 | 109 | 80443 | 50569 | 64367611 |
Dysstasia | 13.55 | 11.11 | 6 | 80546 | 23209 | 64394971 |
Blood lactate dehydrogenase increased | 13.54 | 11.11 | 79 | 80473 | 32999 | 64385181 |
Bacteraemia | 13.54 | 11.11 | 68 | 80484 | 26843 | 64391337 |
Gait inability | 13.46 | 11.11 | 20 | 80532 | 42348 | 64375832 |
Tetany | 13.37 | 11.11 | 15 | 80537 | 2157 | 64416023 |
Pneumonia mycoplasmal | 13.35 | 11.11 | 12 | 80540 | 1324 | 64416856 |
Encephalomalacia | 13.34 | 11.11 | 11 | 80541 | 1080 | 64417100 |
POEMS syndrome | 13.30 | 11.11 | 4 | 80548 | 39 | 64418141 |
Product substitution issue | 13.29 | 11.11 | 3 | 80549 | 17858 | 64400322 |
Oral pain | 13.29 | 11.11 | 9 | 80543 | 27484 | 64390696 |
Hypophagia | 13.26 | 11.11 | 18 | 80534 | 39569 | 64378611 |
Meningitis | 13.26 | 11.11 | 31 | 80521 | 8298 | 64409882 |
Eye pain | 13.21 | 11.11 | 12 | 80540 | 31613 | 64386567 |
Palmar-plantar erythrodysaesthesia syndrome | 13.19 | 11.11 | 10 | 80542 | 28809 | 64389371 |
Unevaluable event | 13.16 | 11.11 | 27 | 80525 | 50462 | 64367718 |
Pollakiuria | 13.12 | 11.11 | 12 | 80540 | 31518 | 64386662 |
Toxic shock syndrome | 13.12 | 11.11 | 10 | 80542 | 876 | 64417304 |
Eosinophilic pneumonia acute | 13.11 | 11.11 | 10 | 80542 | 877 | 64417303 |
Hyper IgE syndrome | 13.10 | 11.11 | 8 | 80544 | 487 | 64417693 |
Dysmetria | 13.02 | 11.11 | 10 | 80542 | 886 | 64417294 |
Anoxia | 12.95 | 11.11 | 7 | 80545 | 338 | 64417842 |
Serum ferritin increased | 12.92 | 11.11 | 31 | 80521 | 8437 | 64409743 |
Generalised bullous fixed drug eruption | 12.91 | 11.11 | 3 | 80549 | 9 | 64418171 |
Haemorrhoids thrombosed | 12.91 | 11.11 | 6 | 80546 | 209 | 64417971 |
Hepatic necrosis | 12.91 | 11.11 | 31 | 80521 | 8442 | 64409738 |
Clostridial infection | 12.84 | 11.11 | 23 | 80529 | 5096 | 64413084 |
Biliary dilatation | 12.84 | 11.11 | 15 | 80537 | 2253 | 64415927 |
Foetal death | 12.82 | 11.11 | 25 | 80527 | 5905 | 64412275 |
Gastrointestinal mucormycosis | 12.81 | 11.11 | 7 | 80545 | 345 | 64417835 |
Epistaxis | 12.81 | 11.11 | 71 | 80481 | 98060 | 64320120 |
Osteonecrosis | 12.66 | 11.11 | 10 | 80542 | 28219 | 64389961 |
Histoplasmosis disseminated | 12.64 | 11.11 | 14 | 80538 | 1984 | 64416196 |
Intravascular haemolysis | 12.63 | 11.11 | 9 | 80543 | 711 | 64417469 |
Necrosis | 12.56 | 11.11 | 30 | 80522 | 8141 | 64410039 |
Multiple sclerosis | 12.55 | 11.11 | 4 | 80548 | 18937 | 64399243 |
Metastases to heart | 12.52 | 11.11 | 6 | 80546 | 224 | 64417956 |
Chondrocalcinosis | 12.52 | 11.11 | 9 | 80543 | 721 | 64417459 |
Haemoglobinuria | 12.49 | 11.11 | 9 | 80543 | 724 | 64417456 |
Overlap syndrome | 12.45 | 11.11 | 9 | 80543 | 727 | 64417453 |
Liver abscess | 12.33 | 11.11 | 23 | 80529 | 5257 | 64412923 |
Petechiae | 12.30 | 11.11 | 51 | 80501 | 18575 | 64399605 |
Bronchial obstruction | 12.28 | 11.11 | 15 | 80537 | 2359 | 64415821 |
Neuralgic amyotrophy | 12.28 | 11.11 | 6 | 80546 | 234 | 64417946 |
Sinus disorder | 12.26 | 11.11 | 3 | 80549 | 16905 | 64401275 |
Ototoxicity | 12.18 | 11.11 | 16 | 80536 | 2707 | 64415473 |
C-reactive protein increased | 12.13 | 11.11 | 176 | 80376 | 94733 | 64323447 |
Wound haemorrhage | 12.12 | 11.11 | 18 | 80534 | 3413 | 64414767 |
Streptococcal infection | 12.08 | 11.11 | 28 | 80524 | 7451 | 64410729 |
Pulmonary function test | 12.06 | 11.11 | 3 | 80549 | 13 | 64418167 |
Azotaemia | 12.03 | 11.11 | 28 | 80524 | 7474 | 64410706 |
Drug hypersensitivity | 11.96 | 11.11 | 385 | 80167 | 237430 | 64180750 |
Heart rate irregular | 11.93 | 11.11 | 10 | 80542 | 27403 | 64390777 |
Subdural abscess | 11.92 | 11.11 | 4 | 80548 | 57 | 64418123 |
Infection | 11.88 | 11.11 | 161 | 80391 | 184719 | 64233461 |
Urine potassium increased | 11.87 | 11.11 | 3 | 80549 | 14 | 64418166 |
Meningitis candida | 11.87 | 11.11 | 5 | 80547 | 137 | 64418043 |
Bursitis | 11.85 | 11.11 | 6 | 80546 | 21479 | 64396701 |
Asthma | 11.84 | 11.11 | 70 | 80482 | 95155 | 64323025 |
Skin discolouration | 11.84 | 11.11 | 16 | 80536 | 35239 | 64382941 |
CSF oligoclonal band present | 11.81 | 11.11 | 5 | 80547 | 139 | 64418041 |
Dependence on oxygen therapy | 11.79 | 11.11 | 7 | 80545 | 405 | 64417775 |
Tissue infiltration | 11.78 | 11.11 | 8 | 80544 | 585 | 64417595 |
Conjunctival hyperaemia | 11.74 | 11.11 | 19 | 80533 | 3880 | 64414300 |
Crying | 11.73 | 11.11 | 53 | 80499 | 20037 | 64398143 |
Coagulation factor V level decreased | 11.71 | 11.11 | 8 | 80544 | 591 | 64417589 |
Localised oedema | 11.70 | 11.11 | 27 | 80525 | 7164 | 64411016 |
Haemoperitoneum | 11.68 | 11.11 | 19 | 80533 | 3896 | 64414284 |
Vitamin A deficiency | 11.61 | 11.11 | 4 | 80548 | 62 | 64418118 |
Skin test positive | 11.60 | 11.11 | 10 | 80542 | 1043 | 64417137 |
Disturbance in attention | 11.55 | 11.11 | 21 | 80531 | 41053 | 64377127 |
Periostosis | 11.54 | 11.11 | 3 | 80549 | 16 | 64418164 |
Neisseria infection | 11.49 | 11.11 | 4 | 80548 | 64 | 64418116 |
Allergy test positive | 11.42 | 11.11 | 7 | 80545 | 429 | 64417751 |
Coagulation factor V level abnormal | 11.39 | 11.11 | 3 | 80549 | 17 | 64418163 |
CD4 lymphocytes increased | 11.39 | 11.11 | 6 | 80546 | 275 | 64417905 |
Panic attack | 11.33 | 11.11 | 6 | 80546 | 20947 | 64397233 |
Faeces pale | 11.33 | 11.11 | 15 | 80537 | 2556 | 64415624 |
Normochromic anaemia | 11.33 | 11.11 | 7 | 80545 | 435 | 64417745 |
Glycosylated haemoglobin increased | 11.32 | 11.11 | 3 | 80549 | 16016 | 64402164 |
Unmasking of previously unidentified disease | 11.22 | 11.11 | 12 | 80540 | 1635 | 64416545 |
Cell death | 11.19 | 11.11 | 19 | 80533 | 4035 | 64414145 |
Acidosis | 11.19 | 11.11 | 48 | 80504 | 17747 | 64400433 |
Alpha 1 microglobulin increased | 11.16 | 11.11 | 4 | 80548 | 70 | 64418110 |
Hepatic failure | 11.15 | 11.11 | 112 | 80440 | 55282 | 64362898 |
None
Source | Code | Description |
---|---|---|
ATC | J01DD04 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Third-generation cephalosporins |
ATC | J01DD54 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Third-generation cephalosporins |
ATC | J01DD63 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Third-generation cephalosporins |
FDA CS | M0003827 | Cephalosporins |
FDA EPC | N0000175488 | Cephalosporin Antibacterial |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
CHEBI has role | CHEBI:35625 | beta-lactamase inhibitors |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
CHEBI has role | CHEBI:88188 | allergenic drug |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Gonococcal meningitis | indication | 151004 | |
Streptococcal meningitis | indication | 4510004 | DOID:11574 |
Septicemia due to Escherichia coli | indication | 9323009 | |
Bacterial septicemia | indication | 10001005 | DOID:0040085 |
Staphylococcal meningitis | indication | 12166008 | |
Gonorrhea | indication | 15628003 | DOID:7551 |
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Acute gonococcal cervicitis | indication | 20943002 | DOID:10615 |
Staphylococcal pneumonia | indication | 22754005 | |
Streptococcal septicemia | indication | 29577008 | |
Acute gonococcal urethritis | indication | 29864006 | |
Pneumonia due to Streptococcus | indication | 34020007 | |
Gonorrhea of rectum | indication | 42746002 | |
Gonococcal infection of joint | indication | 44743006 | |
Bacterial arthritis | indication | 48245008 | |
Salmonella septicemia | indication | 49786009 | |
Lower respiratory tract infection | indication | 50417007 | |
Pneumococcal meningitis | indication | 51169003 | |
Pneumonia due to Escherichia coli | indication | 51530003 | |
Bacterial pneumonia | indication | 53084003 | DOID:874 |
Klebsiella cystitis | indication | 60867007 | |
Gonococcal endocarditis | indication | 61048000 | |
Acute gonococcal endometritis | indication | 65295003 | DOID:7527 |
Haemophilus influenzae pneumonia | indication | 70036007 | |
Infection due to Escherichia coli | indication | 71057007 | |
Bacterial infection due to Serratia | indication | 71120004 | |
Rhinoscleroma | indication | 72409005 | DOID:11336 |
Gonorrhea of pharynx | indication | 74372003 | |
Endometritis | indication | 78623009 | DOID:1002 |
Bacterial meningitis | indication | 95883001 | DOID:9470 |
Infection of bone | indication | 111253001 | |
Staphylococcal septicemia | indication | 111821004 | |
Female genital tract infection | indication | 125585007 | |
Infectious disease of abdomen | indication | 128070006 | |
Infection due to Enterobacteriaceae | indication | 128945009 | |
Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
Meningococcal meningitis | indication | 192644005 | |
Escherichia coli meningitis | indication | 192655005 | |
Proteus pneumonia | indication | 195888009 | |
Chancroid | indication | 266143009 | DOID:13778 |
Escherichia coli urinary tract infection | indication | 301011002 | |
Proteus urinary tract infection | indication | 301012009 | |
Streptococcus pyogenes infection | indication | 302809008 | |
Bacterial urinary infection | indication | 312124009 | |
Infective otitis media | indication | 312218008 | |
Infectious disorder of joint | indication | 363162000 | |
Meningitis due to Klebsiella mobilis | indication | 420585007 | |
Peptostreptococcus infection | indication | 135341000119101 | |
Klebsiella Pneumoniae Osteomyelitis | indication | ||
Inflammatory Disease of Female Pelvic Organs | indication | ||
Proteus Mirabilis Osteomyelitis | indication | ||
Peptostreptococcus Peritonitis | indication | ||
Enterobacter Pneumonia | indication | ||
Proteus Joint Infection | indication | ||
E. Coli Peritonitis | indication | ||
Skin and Skin Structure Serratia Infection | indication | ||
Haemophilus Septic Arthritis | indication | ||
Prevention of Perioperative Infection | indication | ||
Haemophilus Influenzae Type B Infections | indication | ||
Adult Gonococcal Conjunctivitis | indication | ||
E. Coli Septic Arthritis | indication | ||
Haemophilus Septicemia | indication | ||
Disseminated Gonococcal Infection | indication | ||
Klebsiella Pneumoniae Peritonitis | indication | ||
H. Influenzae Meningitis | indication | ||
Prevention of Meningococcal Meningitis | indication | ||
Gram-Negative Aerobic Bacillary Pneumonia | indication | ||
Skin and Skin Structure Proteus Infection | indication | ||
Haemophilus Osteomyelitis | indication | ||
Haemophilus Parainfluenzae Pneumonia | indication | ||
Enterobacter Osteomyelitis | indication | ||
Streptococcal Joint Infection | indication | ||
Pelvic Inflammatory Disease with Neisseria Gonorrhea | indication | ||
Klebsiella Joint Infection | indication | ||
EnterobacterJoint Infection | indication | ||
Skin and Skin Structure Morganella Morganii Infection | indication | ||
Streptococcus Osteomyelitis | indication | ||
E. Coli Joint Infection | indication | ||
E. Coli Osteomyelitis | indication | ||
Pyrexia of unknown origin | off-label use | 7520000 | |
Lyme disease | off-label use | 23502006 | DOID:11729 |
Lyme arthritis | off-label use | 33937009 | |
Pseudotuberculosis | off-label use | 36753006 | |
Lyme carditis | off-label use | 77863005 | |
Infection by Yersinia enterocolitica | off-label use | 80960004 | |
Ventilator-acquired pneumonia | off-label use | 429271009 | |
Lyme Disease of the Central Nervous System | off-label use | ||
Sexual Transmitted Disease Exposure from Sexual Assault | off-label use | ||
Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
Acute nephropathy | contraindication | 58574008 | |
Hemolytic anemia | contraindication | 61261009 | DOID:583 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Neonatal hyperbilirubinemia | contraindication | 281610001 | |
Pseudomembranous enterocolitis | contraindication | 397683000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.65 | acidic |
pKa2 | 4.17 | acidic |
pKa3 | 13.31 | acidic |
pKa4 | 3.29 | Basic |
pKa5 | 0.93 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
D-amino-acid oxidase | Enzyme | IC50 | 5 | CHEMBL | |||||
Alpha-synuclein | Transporter | Kd | 6.28 | CHEMBL | |||||
Peptidoglycan synthase FtsI | Enzyme | INHIBITOR | IC50 | 6.14 | WOMBAT-PK | CHEMBL | |||
Penicillin-binding protein 1A | Enzyme | INHIBITOR | IC50 | 6.51 | WOMBAT-PK | CHEMBL | |||
Penicillin-binding protein 1B | Enzyme | INHIBITOR | IC50 | 5.74 | WOMBAT-PK | CHEMBL | |||
Penicillin-binding protein 2 | Enzyme | INHIBITOR | IC50 | 6.21 | WOMBAT-PK | CHEMBL |
ID | Source |
---|---|
4019667 | VUID |
N0000147759 | NUI |
D00924 | KEGG_DRUG |
104376-79-6 | SECONDARY_CAS_RN |
203172 | RXNORM |
4017814 | VANDF |
4019667 | VANDF |
C0007561 | UMLSCUI |
CHEBI:29007 | CHEBI |
9F2 | PDB_CHEM_ID |
CHEMBL1200995 | ChEMBL_ID |
CHEMBL161 | ChEMBL_ID |
CHEMBL3183968 | ChEMBL_ID |
D002443 | MESH_DESCRIPTOR_UI |
DB01212 | DRUGBANK_ID |
5326 | IUPHAR_LIGAND_ID |
4923 | INN_ID |
75J73V1629 | UNII |
5479530 | PUBCHEM_CID |
1314 | MMSL |
4387 | MMSL |
69782 | MMSL |
d00052 | MMSL |
002734 | NDDF |
004849 | NDDF |
19841008 | SNOMEDCT_US |
33440000 | SNOMEDCT_US |
372670001 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9678 | INJECTION, POWDER, FOR SOLUTION | 10 g | INTRAVENOUS | ANDA | 26 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9768 | INJECTION, POWDER, FOR SOLUTION | 10 g | INTRAVENOUS | ANDA | 23 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9856 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAMUSCULAR | ANDA | 24 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9857 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAMUSCULAR | ANDA | 24 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9858 | INJECTION, POWDER, FOR SOLUTION | 500 mg | INTRAMUSCULAR | ANDA | 24 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9859 | INJECTION, POWDER, FOR SOLUTION | 250 mg | INTRAMUSCULAR | ANDA | 24 sections |
CEFTRIAXONE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3153 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 27 sections |
CEFTRIAXONE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3155 | INJECTION, SOLUTION | 2 g | INTRAVENOUS | NDA | 27 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-5002 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | ANDA | 23 sections |
Ceftriaxone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-5003 | INJECTION, SOLUTION | 2 g | INTRAVENOUS | ANDA | 23 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7332 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 24 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7332 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 24 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7332 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 24 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7332 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 24 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7333 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 21 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7333 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 21 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7333 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 21 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7333 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 21 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7334 | INJECTION, POWDER, FOR SOLUTION | 10 g | INTRAVENOUS | ANDA | 25 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7334 | INJECTION, POWDER, FOR SOLUTION | 10 g | INTRAVENOUS | ANDA | 25 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7334 | INJECTION, POWDER, FOR SOLUTION | 10 g | INTRAVENOUS | ANDA | 25 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7334 | INJECTION, POWDER, FOR SOLUTION | 10 g | INTRAVENOUS | ANDA | 25 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7335 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 24 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7335 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 24 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7335 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 24 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7335 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 24 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7336 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 21 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7336 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 21 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7336 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 21 sections |
Ceftriaxone Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7336 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 21 sections |