toceranib 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| angiogenesis inhibitors | 5634 | 356068-94-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A tyrosine kinase inhibitor
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Dogs | Treatment of Patnaik grade II or III, recurrent, cutaneous mast cell tumors with or without regional lymph node involvement | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Palladia | Zoetis Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta | Kinase | IC50 | 9 | CHEMBL | |||||
| Vascular endothelial growth factor receptor 2 | Kinase | INHIBITOR | Ki | 8.22 | IUPHAR | ||||
| Platelet-derived growth factor receptor alpha | Kinase | INHIBITOR | Ki | 8.30 | IUPHAR | ||||
| Fibroblast growth factor receptor 1 | Kinase | INHIBITOR | Ki | 6.30 | IUPHAR | ||||
| Vascular endothelial growth factor receptor 2 | Kinase | INHIBITOR | Ki | 8.22 | IUPHAR | ||||
| Fibroblast growth factor receptor 1 | Kinase | INHIBITOR | Ki | 6.30 | IUPHAR | ||||
| Platelet-derived growth factor receptor alpha | Kinase | INHIBITOR | Ki | 8.30 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| CHEMBL13608 | ChEMBL_ID |
| C464577 | MESH_SUPPLEMENTAL_RECORD_UI |
| 11619 | IUPHAR_LIGAND_ID |
| 017775 | NDDF |
| 017776 | NDDF |
| C2825368 | UMLSCUI |
| BWC | PDB_CHEM_ID |
| CHEMBL2103833 | ChEMBL_ID |
| 9069 | INN_ID |
| 449278009 | SNOMEDCT_US |
| 449541005 | SNOMEDCT_US |
| 768537000 | SNOMEDCT_US |
| 874819-74-6 | SECONDARY_CAS_RN |
| D08503 | KEGG_DRUG |
| 5329106 | PUBCHEM_CID |
| 1145944 | RXNORM |
| 59L7Y0530C | UNII |
Pharmaceutical products:
None