maduramicin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| aminoglycosides, antibiotics obtained from various Micromonospora | 5571 | 84878-61-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Isolated from Actinomadura rubra
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Chickens | Prevention of coccidiosis caused by Eimeria acervulina | Indication |
| Chickens | Prevention of coccidiosis caused by Eimeria tenella | Indication |
| Chickens | Prevention of coccidiosis caused by E brunetti | Indication |
| Chickens | Prevention of coccidiosis caused by E maxima | Indication |
| Chickens | Prevention of coccidiosis caused by E necatrix | Indication |
| Chickens | Prevention of coccidiosis caused by E mivati | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Cygro | Zoetis Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| D(1A) dopamine receptor | GPCR | Ki | 5.84 | CHEMBL | |||||
| D(2) dopamine receptor | GPCR | Ki | 6.63 | CHEMBL | |||||
| Alpha-2A adrenergic receptor | GPCR | Ki | 7.17 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 2A | GPCR | Ki | 8.61 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 2B | GPCR | Ki | 7.68 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 2C | GPCR | Ki | 7.75 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 6 | GPCR | Ki | 9.10 | CHEMBL | |||||
| Alpha-2B adrenergic receptor | GPCR | Ki | 7.92 | CHEMBL | |||||
| D(3) dopamine receptor | GPCR | Ki | 8.03 | CHEMBL | |||||
| Alpha-2C adrenergic receptor | GPCR | Ki | 6.63 | CHEMBL | |||||
| Cytochrome P450 2D6 | Enzyme | IC50 | 6 | CHEMBL | |||||
| Alpha-1D adrenergic receptor | GPCR | Ki | 6.26 | CHEMBL | |||||
| Alpha-1B adrenergic receptor | GPCR | Ki | 5.58 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 1B | GPCR | Ki | 8.87 | CHEMBL | |||||
| Alpha-1A adrenergic receptor | GPCR | Ki | 5.87 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 1A | GPCR | Ki | 8.35 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| CHEMBL1909065 | ChEMBL_ID |
| CHEMBL2105807 | ChEMBL_ID |
| C018091 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB11525 | DRUGBANK_ID |
| C0065503 | UMLSCUI |
| 5670 | INN_ID |
| 96159004 | SNOMEDCT_US |
| KEGG_DRUG | |
| 68595 | PUBCHEM_CID |
| 5U912U22T2 | UNII |
Pharmaceutical products:
None