fluprostenol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| prostaglandins | 5546 | 40666-16-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Synthetic prostaglandin alpha analog used as an abortifacient
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D003270 | Contraceptive Agents |
| MeSH PA | D003271 | Contraceptive Agents, Female |
| MeSH PA | D000080066 | Contraceptive Agents, Hormonal |
| MeSH PA | D008186 | Luteolytic Agents |
| MeSH PA | D012102 | Reproductive Control Agents |
| CHEBI has role | CHEBI:35674 | antihypertensive drugs |
| CHEBI has role | CHEBI:39456 | antiglaucoma agent |
| CHEBI has role | CHEBI:49324 | female contraceptive drugs |
| CHEBI has role | CHEBI:50691 | abortifacient drug |
| CHEBI has role | CHEBI:66900 | prostaglandin receptor agonists |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Horses | Control the timing of estrus in estrous cycling and in clinically anestrous mares that have a corpus luteum | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Equimate | Elanco US Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP3 subtype | GPCR | AGONIST | Ki | 6.15 | IUPHAR | ||||
| Prostaglandin F2-alpha receptor | GPCR | AGONIST | Ki | 8.60 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| CHEBI:60782 | CHEBI |
| CHEMBL1201379 | ChEMBL_ID |
| C006326 | MESH_SUPPLEMENTAL_RECORD_UI |
| 1940 | IUPHAR_LIGAND_ID |
| DB11519 | DRUGBANK_ID |
| C0060587 | UMLSCUI |
| CHEMBL2107435 | ChEMBL_ID |
| 3794 | INN_ID |
| 96354004 | SNOMEDCT_US |
| 55028-71-2 | SECONDARY_CAS_RN |
| KEGG_DRUG | |
| 5311100 | PUBCHEM_CID |
| 358S7VUE5N | UNII |
Pharmaceutical products:
None