firocoxib 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| selective cyclo-oxygenase inhibitors | 5542 | 189954-96-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A COX-2 inhibitor
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory agent |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:50629 | COX-2 inhibitor |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Dogs | Pain and inflammation associated with osteoarthritis | Indication |
| Dogs | Postoperative pain and inflammation associated with soft-tissue and orthopedic surgery | Indication |
| Horses | Pain and inflammation associated with osteoarthritis | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Previcox Chewable Tablets | Boehringer lngelheim Animal Health USA Inc. | 1 |
| Equioxx Oral Paste | Boehringer lngelheim Animal Health USA Inc. | 1 |
| Equioxx Injection | Boehringer lngelheim Animal Health USA Inc. | 1 |
| Equioxx | Boehringer lngelheim Animal Health USA Inc. | 1 |
| Firox | Norbrook Laboratories, Ltd. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 2 | Enzyme | IC50 | 6.85 | CHEMBL | |||||
| Prostaglandin G/H synthase 1 | Enzyme | IC50 | 4.60 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| CHEBI:76136 | CHEBI |
| CHEMBL69998 | ChEMBL_ID |
| C487384 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB09217 | DRUGBANK_ID |
| 017777 | NDDF |
| C1453102 | UMLSCUI |
| 8359 | INN_ID |
| 423045006 | SNOMEDCT_US |
| 424766004 | SNOMEDCT_US |
| D03712 | KEGG_DRUG |
| 208910 | PUBCHEM_CID |
| 473298 | RXNORM |
| Y6V2W4S4WT | UNII |
Pharmaceutical products:
None