tapinarof 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
5521 79338-84-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tapinarof
  • vtama
  • GSK2894512
  • DMVT-505
  • WBI-1001
Tapinarof is an aryl hydrocarbon receptor (AhR) agonist. The specific mechanisms by which VTAMA cream exerts its therapeutic action in psoriasis patients are unknown.
  • Molecular weight: 254.33
  • Formula: C17H18O2
  • CLOGP: 4.39
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 2
  • TPSA: 40.46
  • ALOGS: -3.87
  • ROTB: 3
  • Status: ONP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 23, 2022 FDA DERMAVANT SCIENCES INC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Plaque psoriasis indication 200965009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Aryl hydrocarbon receptor Transcription factor INHIBITOR EC50 9.80 SCIENTIFIC LITERATURE DRUG LABEL

External reference:

IDSource
CHEMBL259571 ChEMBL_ID
C571829 MESH_SUPPLEMENTAL_RECORD_UI
9686 IUPHAR_LIGAND_ID
10253 INN_ID
84HW7D0V04 UNII
6439522 PUBCHEM_CID
DB06083 DRUGBANK_ID
C4541381 UMLSCUI
D11365 KEGG_DRUG

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
VTAMA HUMAN PRESCRIPTION DRUG LABEL 1 81672-5051 CREAM 10 mg TOPICAL NDA 23 sections