difamilast 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| phosphodiesterase IV (PDE IV) inhibitors | 5503 | 937782-05-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Difamilast is a novel atopic dermatitis drug that has phosphodiesterase 4 inhibitory activity. PDE4 inhibitors are believed to improve the symptoms of atopic dermatitis through suppression of the production of chemical mediators such as pro-inflammatory cytokines and through other anti-inflammatory effects.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 27, 2021 | PMDA | OTSUKA PHARMACEUTICAL Co., Ltd |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Atopic dermatitis | indication | 24079001 | DOID:3310 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Enzyme | INHIBITOR | IC50 | 7.95 | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| CHEMBL3989968 | ChEMBL_ID |
| C000711049 | MESH_SUPPLEMENTAL_RECORD_UI |
| C119208 | MESH_SUPPLEMENTAL_RECORD_UI |
| 9776 | IUPHAR_LIGAND_ID |
| DB14987 | DRUGBANK_ID |
| D11314 | KEGG_DRUG |
| C5139795 | UMLSCUI |
| CHEMBL225555 | ChEMBL_ID |
| 10717 | INN_ID |
| 57855696 | PUBCHEM_CID |
| T3U32GLJ0F | UNII |
Pharmaceutical products:
None